SIMILAR PATTERNS OF AMINO ACIDS FOR 6CK2_C_IPHC101_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dpt D-DOPACHROME
TAUTOMERASE

(Homo sapiens) 		PF01187
(MIF) 		4 ILE A  61
LEU A  22
HIS A  79
ALA A  25
 None
 0.99A 6ck2C-1dptA:
undetectable
6ck2D-1dptA:
undetectable		 6ck2C-1dptA:
17.54
6ck2D-1dptA:
14.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ecw GAG POLYPROTEIN

(Simian
immunodeficiency
virus) 		PF00540
(Gag_p17) 		4 ILE A  88
LEU A  51
HIS A  33
ALA A  37
 None
 1.04A 6ck2C-1ecwA:
undetectable
6ck2D-1ecwA:
undetectable		 6ck2C-1ecwA:
13.33
6ck2D-1ecwA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fuj PR3

(Homo sapiens) 		PF00089
(Trypsin) 		4 ILE A 106
LEU A  68
HIS A  48
ALA A 112
 None
 0.92A 6ck2C-1fujA:
undetectable
6ck2D-1fujA:
undetectable		 6ck2C-1fujA:
10.23
6ck2D-1fujA:
9.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h1y D-RIBULOSE-5-PHOSPHA
TE 3-EPIMERASE

(Oryza sativa) 		PF00834
(Ribul_P_3_epim) 		4 ILE A  55
LEU A  35
HIS A  61
ALA A  24
 None
 1.02A 6ck2C-1h1yA:
undetectable
6ck2D-1h1yA:
undetectable		 6ck2C-1h1yA:
8.21
6ck2D-1h1yA:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iq0 ARGINYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		4 ILE A 132
LEU A 584
HIS A 526
ALA A 529
 None
 0.98A 6ck2C-1iq0A:
undetectable
6ck2D-1iq0A:
undetectable		 6ck2C-1iq0A:
2.85
6ck2D-1iq0A:
4.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ko8 GLUCONATE KINASE

(Escherichia
coli) 		PF01202
(SKI) 		4 ILE A 168
LEU A  84
HIS A  33
ALA A  34
 None
 1.04A 6ck2C-1ko8A:
undetectable
6ck2D-1ko8A:
undetectable		 6ck2C-1ko8A:
5.77
6ck2D-1ko8A:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lgh LIGHT HARVESTING
COMPLEX II
LIGHT HARVESTING
COMPLEX II

(Phaeospirillum
molischianum;
Phaeospirillum
molischianum) 		PF00556
(LHC)
PF00556
(LHC) 		4 ILE A  13
LEU B   8
HIS B  17
ALA B  13
 None
None
BCL  A  58 ( 4.1A)
None
 1.04A 6ck2C-1lghA:
undetectable
6ck2D-1lghA:
undetectable		 6ck2C-1lghA:
8.93
6ck2D-1lghA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mr2 ADPR PYROPHOSPHATASE

(Mycobacterium
tuberculosis) 		PF00293
(NUDIX) 		4 ILE A  57
LEU A 108
HIS A 177
ALA A 175
 None
 0.90A 6ck2C-1mr2A:
undetectable
6ck2D-1mr2A:
undetectable		 6ck2C-1mr2A:
6.10
6ck2D-1mr2A:
10.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nyl GLUTAMINYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C) 		4 ILE A  81
LEU A  88
HIS A  40
ALA A  44
 None
 1.01A 6ck2C-1nylA:
undetectable
6ck2D-1nylA:
undetectable		 6ck2C-1nylA:
5.64
6ck2D-1nylA:
4.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o8u 6-OXO CAMPHOR
HYDROLASE

(Rhodococcus
erythropolis) 		PF00378
(ECH_1) 		4 ILE A  77
LEU A  38
HIS A  45
ALA A  44
 None
 1.02A 6ck2C-1o8uA:
undetectable
6ck2D-1o8uA:
undetectable		 6ck2C-1o8uA:
6.55
6ck2D-1o8uA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ot5 KEXIN

(Saccharomyces
cerevisiae) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		4 ILE A 373
LEU A 185
HIS A 381
ALA A 218
 None
 0.95A 6ck2C-1ot5A:
undetectable
6ck2D-1ot5A:
undetectable		 6ck2C-1ot5A:
4.42
6ck2D-1ot5A:
5.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p88 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Escherichia
coli) 		PF00275
(EPSP_synthase) 		4 ILE A 191
LEU A 176
HIS A 128
ALA A 132
 None
 0.87A 6ck2C-1p88A:
undetectable
6ck2D-1p88A:
undetectable		 6ck2C-1p88A:
14.29
6ck2D-1p88A:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qhb HALOPEROXIDASE

(Corallina
officinalis) 		PF01569
(PAP2) 		4 ILE A 543
LEU A 560
HIS A 485
ALA A 489
 None
None
PO4  A3000 ( 3.9A)
None
 0.96A 6ck2C-1qhbA:
undetectable
6ck2D-1qhbA:
undetectable		 6ck2C-1qhbA:
3.80
6ck2D-1qhbA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sxj ACTIVATOR 1 37 KDA
SUBUNIT

(Saccharomyces
cerevisiae) 		PF00004
(AAA)
PF08542
(Rep_fac_C) 		4 ILE B  36
LEU B 161
HIS B  44
ALA B 159
 None
 1.03A 6ck2C-1sxjB:
undetectable
6ck2D-1sxjB:
undetectable		 6ck2C-1sxjB:
5.02
6ck2D-1sxjB:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u3i GLUTATHIONE
S-TRANSFERASE 28 KDA

(Schistosoma
mansoni) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 ILE A  20
LEU A 161
HIS A  82
ALA A  26
 None
 1.03A 6ck2C-1u3iA:
undetectable
6ck2D-1u3iA:
undetectable		 6ck2C-1u3iA:
9.09
6ck2D-1u3iA:
6.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v10 LACCASE

(Rigidoporus
microporus) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ILE A  87
LEU A 120
HIS A   8
ALA A  27
 None
 0.85A 6ck2C-1v10A:
undetectable
6ck2D-1v10A:
undetectable		 6ck2C-1v10A:
3.97
6ck2D-1v10A:
5.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vf8 SECRETORY PROTEIN

(Mus musculus) 		PF00704
(Glyco_hydro_18) 		4 ILE A 225
LEU A 239
HIS A 232
ALA A 234
 None
 0.82A 6ck2C-1vf8A:
undetectable
6ck2D-1vf8A:
undetectable		 6ck2C-1vf8A:
5.00
6ck2D-1vf8A:
6.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybw HEPATOCYTE GROWTH
FACTOR ACTIVATOR
PRECURSOR

(Homo sapiens) 		PF00089
(Trypsin) 		4 ILE A 501
LEU A 462
HIS A 438
ALA A 511
 None
 0.91A 6ck2C-1ybwA:
undetectable
6ck2D-1ybwA:
undetectable		 6ck2C-1ybwA:
7.11
6ck2D-1ybwA:
7.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yk3 HYPOTHETICAL PROTEIN
RV1347C/MT1389

(Mycobacterium
tuberculosis) 		PF13523
(Acetyltransf_8) 		4 ILE A 165
LEU A 148
HIS A 130
ALA A 131
 None
 1.04A 6ck2C-1yk3A:
undetectable
6ck2D-1yk3A:
undetectable		 6ck2C-1yk3A:
9.09
6ck2D-1yk3A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zun SULFATE ADENYLATE
TRANSFERASE, SUBUNIT
1/ADENYLYLSULFATE
KINASE

(Pseudomonas
syringae group
genomosp. 3) 		PF00009
(GTP_EFTU) 		4 ILE B 276
LEU B 265
HIS B 271
ALA B 300
 None
 0.96A 6ck2C-1zunB:
undetectable
6ck2D-1zunB:
undetectable		 6ck2C-1zunB:
5.39
6ck2D-1zunB:
5.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btv PROTEIN (VP3 CORE
PROTEIN)

(Bluetongue
virus) 		PF01700
(Orbi_VP3) 		4 ILE A 131
LEU A 697
HIS A 616
ALA A 691
 None
 0.99A 6ck2C-2btvA:
undetectable
6ck2D-2btvA:
undetectable		 6ck2C-2btvA:
4.31
6ck2D-2btvA:
3.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cai GLUTATHIONE
S-TRANSFERASE 28 KDA

(Schistosoma
haematobium) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 ILE A  20
LEU A 161
HIS A  82
ALA A  26
 None
 1.00A 6ck2C-2caiA:
undetectable
6ck2D-2caiA:
undetectable		 6ck2C-2caiA:
8.45
6ck2D-2caiA:
8.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ery RAS-RELATED PROTEIN
R-RAS2

(Homo sapiens) 		PF00071
(Ras) 		4 ILE A  66
LEU A  90
HIS A 169
ALA A 167
 None
 0.99A 6ck2C-2eryA:
undetectable
6ck2D-2eryA:
undetectable		 6ck2C-2eryA:
9.52
6ck2D-2eryA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fxv XANTHINE
PHOSPHORIBOSYLTRANSF
ERASE

(Bacillus
subtilis) 		PF00156
(Pribosyltran) 		4 ILE A 122
LEU A 114
HIS A 119
ALA A 145
 None
 1.03A 6ck2C-2fxvA:
undetectable
6ck2D-2fxvA:
undetectable		 6ck2C-2fxvA:
9.32
6ck2D-2fxvA:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2igt SAM DEPENDENT
METHYLTRANSFERASE

(Agrobacterium
fabrum) 		PF10672
(Methyltrans_SAM) 		4 ILE A 208
LEU A 123
HIS A 159
ALA A 146
 None
 0.99A 6ck2C-2igtA:
undetectable
6ck2D-2igtA:
undetectable		 6ck2C-2igtA:
3.63
6ck2D-2igtA:
7.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv2 FORMATE
DEHYDROGENASE H

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 ILE X 161
LEU X 294
HIS X 326
ALA X 292
 None
 0.96A 6ck2C-2iv2X:
undetectable
6ck2D-2iv2X:
undetectable		 6ck2C-2iv2X:
2.90
6ck2D-2iv2X:
4.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2m56 CAMPHOR
5-MONOOXYGENASE

(Pseudomonas
putida) 		PF00067
(p450) 		4 ILE A 300
LEU A 320
HIS A  80
ALA A  74
 None
 1.02A 6ck2C-2m56A:
undetectable
6ck2D-2m56A:
undetectable		 6ck2C-2m56A:
4.35
6ck2D-2m56A:
6.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oq2 PHOSPHOADENOSINE
PHOSPHOSULFATE
REDUCTASE

(Saccharomyces
cerevisiae) 		PF01507
(PAPS_reduct) 		4 ILE A 247
LEU A  74
HIS A 144
ALA A 146
 None
 1.01A 6ck2C-2oq2A:
undetectable
6ck2D-2oq2A:
undetectable		 6ck2C-2oq2A:
7.92
6ck2D-2oq2A:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q3f RAS-RELATED
GTP-BINDING PROTEIN
D

(Homo sapiens) 		PF04670
(Gtr1_RagA) 		4 ILE A 159
LEU A 139
HIS A 178
ALA A 181
 None
 1.05A 6ck2C-2q3fA:
undetectable
6ck2D-2q3fA:
undetectable		 6ck2C-2q3fA:
6.63
6ck2D-2q3fA:
14.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r0l HEPATOCYTE GROWTH
FACTOR ACTIVATOR

(Homo sapiens) 		PF00089
(Trypsin) 		4 ILE A 106
LEU A  68
HIS A  48
ALA A 112
 None
 0.90A 6ck2C-2r0lA:
undetectable
6ck2D-2r0lA:
undetectable		 6ck2C-2r0lA:
7.23
6ck2D-2r0lA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhq PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Staphylococcus
haemolyticus) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		4 ILE B 519
LEU B 578
HIS B 560
ALA B 564
 None
 1.04A 6ck2C-2rhqB:
undetectable
6ck2D-2rhqB:
undetectable		 6ck2C-2rhqB:
4.11
6ck2D-2rhqB:
4.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5q DESIGN ANKYRIN
REPEAT PROTEIN

(unidentified) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		4 ILE C  62
LEU C  51
HIS C  69
ALA C  71
 None
 0.98A 6ck2C-2v5qC:
undetectable
6ck2D-2v5qC:
undetectable		 6ck2C-2v5qC:
6.67
6ck2D-2v5qC:
12.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtz UDP-N-ACETYLMURAMOYL
-L-ALANYL-D-GLUTAMAT
E--2,6-DIAMINOPIMELA
TE LIGASE

(Mycobacterium
tuberculosis) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		4 ILE A 337
LEU A 352
HIS A 334
ALA A 325
 None
 0.97A 6ck2C-2wtzA:
undetectable
6ck2D-2wtzA:
undetectable		 6ck2C-2wtzA:
3.16
6ck2D-2wtzA:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xzd DARPIN-3.4

(synthetic
construct) 		PF12796
(Ank_2) 		4 ILE G  62
LEU G  51
HIS G  69
ALA G  71
 None
 0.95A 6ck2C-2xzdG:
undetectable
6ck2D-2xzdG:
undetectable		 6ck2C-2xzdG:
7.46
6ck2D-2xzdG:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8f RAN-BINDING PROTEIN
3

(Homo sapiens) 		PF00638
(Ran_BP1) 		4 ILE A 407
LEU A 360
HIS A 437
ALA A 435
 None
None
GOL  A1452 ( 4.6A)
None
 1.03A 6ck2C-2y8fA:
undetectable
6ck2D-2y8fA:
undetectable		 6ck2C-2y8fA:
8.70
6ck2D-2y8fA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aii GLUTAMYL-TRNA
SYNTHETASE

(Methanothermobacter
thermautotrophicus) 		PF00749
(tRNA-synt_1c)
PF03950
(tRNA-synt_1c_C) 		4 ILE A 151
LEU A 158
HIS A 110
ALA A 114
 None
 1.00A 6ck2C-3aiiA:
undetectable
6ck2D-3aiiA:
undetectable		 6ck2C-3aiiA:
2.47
6ck2D-3aiiA:
4.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bpt 3-HYDROXYISOBUTYRYL-
COA HYDROLASE

(Homo sapiens) 		PF16113
(ECH_2) 		4 ILE A  86
LEU A  72
HIS A 153
ALA A 127
 None
 1.02A 6ck2C-3bptA:
undetectable
6ck2D-3bptA:
undetectable		 6ck2C-3bptA:
4.74
6ck2D-3bptA:
7.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c18 NUCLEOTIDYLTRANSFERA
SE-LIKE PROTEIN

(Exiguobacterium
sibiricum) 		PF14540
(NTF-like) 		4 ILE A 204
LEU A 211
HIS A 153
ALA A 155
 None
 0.94A 6ck2C-3c18A:
undetectable
6ck2D-3c18A:
undetectable		 6ck2C-3c18A:
7.86
6ck2D-3c18A:
7.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8e YGHU, GLUTATHIONE
S-TRANSFERASE
HOMOLOGUE

(Escherichia
coli) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		4 ILE A 176
LEU A 231
HIS A 166
ALA A 227
 None
 0.98A 6ck2C-3c8eA:
undetectable
6ck2D-3c8eA:
undetectable		 6ck2C-3c8eA:
7.56
6ck2D-3c8eA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cv3 GLUCURONOSYLTRANSFER
ASE GUMK

(Xanthomonas
campestris) 		no annotation 4 ILE A 289
LEU A 316
HIS A 251
ALA A 285
 None
 0.97A 6ck2C-3cv3A:
undetectable
6ck2D-3cv3A:
undetectable		 6ck2C-3cv3A:
4.55
6ck2D-3cv3A:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dv9 BETA-PHOSPHOGLUCOMUT
ASE

(Bacteroides
vulgatus) 		PF13419
(HAD_2) 		4 ILE A  45
LEU A  53
HIS A  38
ALA A  58
 None
 1.03A 6ck2C-3dv9A:
undetectable
6ck2D-3dv9A:
undetectable		 6ck2C-3dv9A:
8.38
6ck2D-3dv9A:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0l GUANINE DEAMINASE

(Homo sapiens) 		PF01979
(Amidohydro_1) 		4 ILE A 209
LEU A 153
HIS A  84
ALA A  85
 None
None
ZN  A1452 (-3.1A)
None
 1.02A 6ck2C-3e0lA:
undetectable
6ck2D-3e0lA:
undetectable		 6ck2C-3e0lA:
7.28
6ck2D-3e0lA:
6.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gpg NON-STRUCTURAL
PROTEIN 3

(Chikungunya
virus) 		PF01661
(Macro) 		4 ILE A  11
LEU A 109
HIS A  67
ALA A  68
 None
 1.02A 6ck2C-3gpgA:
undetectable
6ck2D-3gpgA:
undetectable		 6ck2C-3gpgA:
7.89
6ck2D-3gpgA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3guy SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Vibrio
parahaemolyticus) 		PF00106
(adh_short) 		4 ILE A   4
LEU A  11
HIS A 202
ALA A 198
 None
 1.00A 6ck2C-3guyA:
undetectable
6ck2D-3guyA:
undetectable		 6ck2C-3guyA:
7.18
6ck2D-3guyA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9s INTEGRON CASSETTE
PROTEIN

(Vibrio cholerae) 		PF00583
(Acetyltransf_1) 		4 ILE A  99
LEU A  88
HIS A 106
ALA A  68
 None
 1.04A 6ck2C-3i9sA:
undetectable
6ck2D-3i9sA:
undetectable		 6ck2C-3i9sA:
10.79
6ck2D-3i9sA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qp8 CVIR TRANSCRIPTIONAL
REGULATOR

(Chromobacterium
violaceum) 		PF03472
(Autoind_bind) 		4 ILE A  47
LEU A  40
HIS A 177
ALA A 181
 None
 0.94A 6ck2C-3qp8A:
undetectable
6ck2D-3qp8A:
undetectable		 6ck2C-3qp8A:
5.98
6ck2D-3qp8A:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t6w LACCASE

(Steccherinum
ochraceum) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ILE A  88
LEU A 121
HIS A  10
ALA A  28
 None
 0.96A 6ck2C-3t6wA:
undetectable
6ck2D-3t6wA:
undetectable		 6ck2C-3t6wA:
5.83
6ck2D-3t6wA:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tex PROTECTIVE ANTIGEN

(Bacillus
anthracis) 		PF03495
(Binary_toxB)
PF07691
(PA14)
PF17475
(Binary_toxB_2)
PF17476
(Binary_toxB_3) 		4 ILE A 635
LEU A 498
HIS A 597
ALA A 604
 None
 0.89A 6ck2C-3texA:
undetectable
6ck2D-3texA:
undetectable		 6ck2C-3texA:
3.02
6ck2D-3texA:
5.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tpc SHORT CHAIN ALCOHOL
DEHYDROGENASE-RELATE
D DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00106
(adh_short) 		4 ILE A  11
LEU A  27
HIS A  83
ALA A  32
 None
 1.03A 6ck2C-3tpcA:
undetectable
6ck2D-3tpcA:
undetectable		 6ck2C-3tpcA:
5.04
6ck2D-3tpcA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uit INAD-LIKE PROTEIN,
MAGUK P55 SUBFAMILY
MEMBER 5, PROTEIN
LIN-7 HOMOLOG B

(Homo sapiens;
Mus musculus;
Rattus
norvegicus) 		PF02828
(L27)
PF09045
(L27_2)
PF09060
(L27_N) 		4 ILE A 175
LEU A 197
HIS A 182
ALA A 181
 None
 0.95A 6ck2C-3uitA:
undetectable
6ck2D-3uitA:
undetectable		 6ck2C-3uitA:
4.26
6ck2D-3uitA:
7.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v48 PUTATIVE
AMINOACRYLATE
HYDROLASE RUTD

(Escherichia
coli) 		PF00561
(Abhydrolase_1) 		4 ILE A  19
LEU A   3
HIS A  71
ALA A  73
 None
 0.97A 6ck2C-3v48A:
undetectable
6ck2D-3v48A:
undetectable		 6ck2C-3v48A:
7.85
6ck2D-3v48A:
8.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v98 ARACHIDONATE
5-LIPOXYGENASE

(Homo sapiens) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		4 ILE A 352
LEU A 327
HIS A 360
ALA A 306
 None
 1.03A 6ck2C-3v98A:
undetectable
6ck2D-3v98A:
undetectable		 6ck2C-3v98A:
4.22
6ck2D-3v98A:
4.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zu7 DESIGNED ANKYRIN
REPEAT PROTEIN

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2) 		4 ILE B  62
LEU B  51
HIS B  69
ALA B  71
 None
 0.99A 6ck2C-3zu7B:
undetectable
6ck2D-3zu7B:
undetectable		 6ck2C-3zu7B:
5.99
6ck2D-3zu7B:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a4z ANTIVIRAL HELICASE
SKI2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		4 ILE A 709
LEU A 688
HIS A 695
ALA A 693
 None
 0.97A 6ck2C-4a4zA:
undetectable
6ck2D-4a4zA:
undetectable		 6ck2C-4a4zA:
4.41
6ck2D-4a4zA:
2.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4acq ALPHA-2-MACROGLOBULI
N

(Homo sapiens) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		4 ILE A 528
LEU A 461
HIS A 511
ALA A 478
 None
 0.96A 6ck2C-4acqA:
undetectable
6ck2D-4acqA:
undetectable		 6ck2C-4acqA:
2.61
6ck2D-4acqA:
2.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4afr METACASPASE

(Trypanosoma
brucei) 		PF00656
(Peptidase_C14) 		4 ILE A 134
LEU A 196
HIS A 154
ALA A 208
 None
 0.95A 6ck2C-4afrA:
undetectable
6ck2D-4afrA:
undetectable		 6ck2C-4afrA:
11.76
6ck2D-4afrA:
7.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4buj ANTIVIRAL HELICASE
SKI2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT) 		4 ILE A 709
LEU A 688
HIS A 695
ALA A 693
 None
 0.98A 6ck2C-4bujA:
undetectable
6ck2D-4bujA:
undetectable		 6ck2C-4bujA:
2.74
6ck2D-4bujA:
3.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cpd ALCOHOL
DEHYDROGENASE

(Thermus sp.
ATN1) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ILE A  87
LEU A 126
HIS A  59
ALA A 121
 None
None
ZN  A1200 (-3.4A)
None
 0.95A 6ck2C-4cpdA:
undetectable
6ck2D-4cpdA:
undetectable		 6ck2C-4cpdA:
8.08
6ck2D-4cpdA:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cyd PROBABLE
TRANSCRIPTION
REGULATOR

(Corynebacterium
glutamicum) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		4 ILE A 207
LEU A 158
HIS A 221
ALA A 223
 None
 1.01A 6ck2C-4cydA:
undetectable
6ck2D-4cydA:
undetectable		 6ck2C-4cydA:
8.09
6ck2D-4cydA:
6.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dvh SUPEROXIDE DISMUTASE

(Trypanosoma
cruzi) 		PF00081
(Sod_Fe_N)
PF02777
(Sod_Fe_C) 		4 ILE A  57
LEU A  40
HIS A   0
ALA A   3
 None
 0.65A 6ck2C-4dvhA:
undetectable
6ck2D-4dvhA:
undetectable		 6ck2C-4dvhA:
13.40
6ck2D-4dvhA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwg TTC1975 PEPTIDASE

(Meiothermus
taiwanensis) 		PF05362
(Lon_C)
PF13654
(AAA_32) 		4 ILE A 311
LEU A  39
HIS A  48
ALA A  42
 None
 0.96A 6ck2C-4fwgA:
undetectable
6ck2D-4fwgA:
undetectable		 6ck2C-4fwgA:
4.40
6ck2D-4fwgA:
3.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hgv FUMARATE HYDRATASE
CLASS II

(Sinorhizobium
meliloti) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 ILE A 222
LEU A 298
HIS A 176
ALA A 390
 None
 0.99A 6ck2C-4hgvA:
undetectable
6ck2D-4hgvA:
undetectable		 6ck2C-4hgvA:
4.30
6ck2D-4hgvA:
4.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jzy CRYPTOCHROME-1

(Drosophila
melanogaster) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 ILE A  67
LEU A 180
HIS A  18
ALA A 178
 None
 0.98A 6ck2C-4jzyA:
undetectable
6ck2D-4jzyA:
undetectable		 6ck2C-4jzyA:
4.71
6ck2D-4jzyA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kna N-SUCCINYLGLUTAMATE
5-SEMIALDEHYDE
DEHYDROGENASE

(Burkholderia
thailandensis) 		PF00171
(Aldedh) 		4 ILE A 423
LEU A 390
HIS A 417
ALA A 415
 None
 0.97A 6ck2C-4knaA:
undetectable
6ck2D-4knaA:
undetectable		 6ck2C-4knaA:
3.18
6ck2D-4knaA:
5.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lis UDP-GLUCOSE
4-EPIMERASE

(Aspergillus
nidulans) 		PF16363
(GDP_Man_Dehyd) 		4 ILE A 123
LEU A 270
HIS A 263
ALA A 266
 None
 1.05A 6ck2C-4lisA:
undetectable
6ck2D-4lisA:
undetectable		 6ck2C-4lisA:
3.26
6ck2D-4lisA:
5.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lsz DARPIN D7.18

(synthetic
construct) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		4 ILE E  62
LEU E  51
HIS E  69
ALA E  71
 None
 1.05A 6ck2C-4lszE:
undetectable
6ck2D-4lszE:
undetectable		 6ck2C-4lszE:
7.78
6ck2D-4lszE:
14.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mn5 SENSOR PROTEIN
KINASE WALK

(Staphylococcus
aureus) 		PF13426
(PAS_9) 		4 ILE A 277
LEU A 334
HIS A 364
ALA A 342
 None
None
ZN  A 401 (-3.3A)
None
 0.98A 6ck2C-4mn5A:
undetectable
6ck2D-4mn5A:
undetectable		 6ck2C-4mn5A:
9.38
6ck2D-4mn5A:
10.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o89 RNA 3'-TERMINAL
PHOSPHATE CYCLASE

(Pyrococcus
horikoshii) 		PF01137
(RTC)
PF05189
(RTC_insert) 		4 ILE A  95
LEU A 102
HIS A  50
ALA A  54
 None
 0.78A 6ck2C-4o89A:
undetectable
6ck2D-4o89A:
undetectable		 6ck2C-4o89A:
8.28
6ck2D-4o89A:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oca UDP-4-AMINO-4-DEOXY-
L-ARABINOSE--OXOGLUT
ARATE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF01041
(DegT_DnrJ_EryC1) 		4 ILE A 301
LEU A 319
HIS A 380
ALA A 378
 None
 0.94A 6ck2C-4ocaA:
undetectable
6ck2D-4ocaA:
undetectable		 6ck2C-4ocaA:
5.00
6ck2D-4ocaA:
6.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oya ADENYLATE CYCLASE
TYPE 10

(Homo sapiens) 		PF00211
(Guanylate_cyc) 		4 ILE A 384
LEU A 299
HIS A 320
ALA A 317
 None
 0.86A 6ck2C-4oyaA:
undetectable
6ck2D-4oyaA:
undetectable		 6ck2C-4oyaA:
4.15
6ck2D-4oyaA:
5.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pj3 INTRON-BINDING
PROTEIN AQUARIUS

(Homo sapiens) 		PF13086
(AAA_11)
PF13087
(AAA_12)
PF16399
(Aquarius_N) 		4 ILE A  94
LEU A 146
HIS A 125
ALA A 129
 None
 0.79A 6ck2C-4pj3A:
undetectable
6ck2D-4pj3A:
undetectable		 6ck2C-4pj3A:
1.60
6ck2D-4pj3A:
1.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ptx GLYCOSIDE HYDROLASE
FAMILY 1

(Halothermothrix
orenii) 		PF00232
(Glyco_hydro_1) 		4 ILE A 293
LEU A 395
HIS A 381
ALA A 385
 None
 0.88A 6ck2C-4ptxA:
undetectable
6ck2D-4ptxA:
undetectable		 6ck2C-4ptxA:
3.68
6ck2D-4ptxA:
4.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q5r GLUTATHIONE
S-TRANSFERASE

(Blattella
germanica) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 ILE A 160
LEU A 172
HIS A 166
ALA A 168
 None
 0.97A 6ck2C-4q5rA:
undetectable
6ck2D-4q5rA:
undetectable		 6ck2C-4q5rA:
14.29
6ck2D-4q5rA:
6.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r1z CYP17A1 PROTEIN

(Danio rerio) 		PF00067
(p450) 		4 ILE A 125
LEU A 275
HIS A 142
ALA A 144
 HEM  A 600 ( 4.5A)
None
None
None
 1.04A 6ck2C-4r1zA:
undetectable
6ck2D-4r1zA:
undetectable		 6ck2C-4r1zA:
8.33
6ck2D-4r1zA:
5.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u1r ATP-DEPENDENT
6-PHOSPHOFRUCTOKINAS
E, PLATELET TYPE

(Homo sapiens) 		PF00365
(PFK) 		4 ILE A 491
LEU A 503
HIS A 498
ALA A 414
 None
 1.03A 6ck2C-4u1rA:
undetectable
6ck2D-4u1rA:
undetectable		 6ck2C-4u1rA:
2.75
6ck2D-4u1rA:
5.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB

(Lactococcus
lactis) 		PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C) 		4 ILE A 611
LEU A 434
HIS A 318
ALA A 320
 None
 1.04A 6ck2C-4wd9A:
undetectable
6ck2D-4wd9A:
undetectable		 6ck2C-4wd9A:
3.58
6ck2D-4wd9A:
2.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wfi CUTINASE

(Saccharomonospora
viridis) 		PF03403
(PAF-AH_p_II) 		4 ILE A 196
LEU A 146
HIS A 175
ALA A 103
 None
 0.88A 6ck2C-4wfiA:
undetectable
6ck2D-4wfiA:
undetectable		 6ck2C-4wfiA:
5.90
6ck2D-4wfiA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x0r INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX2

(Homo sapiens) 		no annotation 4 ILE B 115
LEU B 108
HIS B 148
ALA B 152
 None
 0.68A 6ck2C-4x0rB:
undetectable
6ck2D-4x0rB:
undetectable		 6ck2C-4x0rB:
8.20
6ck2D-4x0rB:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xh9 NEUROEPITHELIAL
CELL-TRANSFORMING
GENE 1 PROTEIN

(Homo sapiens) 		PF00169
(PH)
PF00621
(RhoGEF) 		4 ILE A 431
LEU A 405
HIS A 503
ALA A 499
 None
 0.75A 6ck2C-4xh9A:
undetectable
6ck2D-4xh9A:
undetectable		 6ck2C-4xh9A:
5.58
6ck2D-4xh9A:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y7v NUCLEOTIDYL
TRANSFERASE

(Pseudomonas
putida) 		PF00483
(NTP_transferase) 		4 ILE A  89
LEU A 185
HIS A 167
ALA A 125
 None
 1.01A 6ck2C-4y7vA:
undetectable
6ck2D-4y7vA:
undetectable		 6ck2C-4y7vA:
8.45
6ck2D-4y7vA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aqa OFF7_DB04V3

(synthetic
construct) 		PF00023
(Ank)
PF12796
(Ank_2)
PF13354
(Beta-lactamase2) 		4 ILE A  62
LEU A  51
HIS A  69
ALA A  71
 None
 1.02A 6ck2C-5aqaA:
undetectable
6ck2D-5aqaA:
undetectable		 6ck2C-5aqaA:
3.23
6ck2D-5aqaA:
5.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej0 ENVELOPE PROTEIN H3

(Vaccinia virus) 		PF03213
(Pox_P35) 		4 ILE A 189
LEU A 166
HIS A 144
ALA A 142
 None
 1.00A 6ck2C-5ej0A:
undetectable
6ck2D-5ej0A:
undetectable		 6ck2C-5ej0A:
7.65
6ck2D-5ej0A:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f2h UNCHARACTERIZED
PROTEIN

(Bacillus cereus) 		PF02230
(Abhydrolase_2) 		4 ILE A 220
LEU A 129
HIS A 186
ALA A 158
 None
 0.75A 6ck2C-5f2hA:
undetectable
6ck2D-5f2hA:
undetectable		 6ck2C-5f2hA:
7.00
6ck2D-5f2hA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h04 BINARY ENTEROTOXIN
OF CLOSTRIDIUM
PERFRINGENS
COMPONENT A

(Clostridium
perfringens) 		PF03496
(ADPrib_exo_Tox) 		4 ILE A 154
LEU A 186
HIS A 157
ALA A 206
 None
 1.05A 6ck2C-5h04A:
undetectable
6ck2D-5h04A:
undetectable		 6ck2C-5h04A:
6.75
6ck2D-5h04A:
5.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h76 DARPIN,IMMUNOGLOBULI
N G-BINDING PROTEIN
A

(Staphylococcus
aureus;
synthetic
construct) 		PF02216
(B)
PF12796
(Ank_2) 		4 ILE A 163
LEU A 117
HIS A 171
ALA A 137
 None
 1.02A 6ck2C-5h76A:
undetectable
6ck2D-5h76A:
undetectable		 6ck2C-5h76A:
5.58
6ck2D-5h76A:
9.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i14 MUTATED AND
TRUNCATED T4
LYSOZYME

(Escherichia
virus T4) 		PF00959
(Phage_lysozyme) 		4 ILE A 107
LEU A  78
HIS A  89
ALA A  77
 None
None
NI  A 202 (-3.2A)
None
 1.05A 6ck2C-5i14A:
undetectable
6ck2D-5i14A:
undetectable		 6ck2C-5i14A:
13.79
6ck2D-5i14A:
14.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jfc NADH-DEPENDENT
FERREDOXIN:NADP
OXIDOREDUCTASE
SUBUNIT BETA

(Pyrococcus
furiosus) 		PF10418
(DHODB_Fe-S_bind) 		4 ILE S 136
LEU S 151
HIS S 191
ALA S 123
 None
 1.02A 6ck2C-5jfcS:
undetectable
6ck2D-5jfcS:
undetectable		 6ck2C-5jfcS:
4.89
6ck2D-5jfcS:
7.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kc8 GLUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo sapiens) 		PF01094
(ANF_receptor) 		4 ILE A 327
LEU A 334
HIS A 116
ALA A  92
 None
 0.83A 6ck2C-5kc8A:
undetectable
6ck2D-5kc8A:
undetectable		 6ck2C-5kc8A:
8.20
6ck2D-5kc8A:
7.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kca CEREBELLIN-1,CEREBEL
LIN-1,CEREBELLIN-1,G
LUTAMATE RECEPTOR
IONOTROPIC, DELTA-2

(Homo sapiens) 		PF00386
(C1q)
PF01094
(ANF_receptor) 		4 ILE A 813
LEU A 820
HIS A 602
ALA A 578
 None
 0.86A 6ck2C-5kcaA:
undetectable
6ck2D-5kcaA:
undetectable		 6ck2C-5kcaA:
2.58
6ck2D-5kcaA:
3.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mal LIPASE

(Streptomyces
rimosus) 		PF13472
(Lipase_GDSL_2) 		4 ILE A  79
LEU A  65
HIS A 181
ALA A 126
 None
 0.95A 6ck2C-5malA:
undetectable
6ck2D-5malA:
undetectable		 6ck2C-5malA:
8.62
6ck2D-5malA:
8.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mew LACCASE 2

(Steccherinum
murashkinskyi) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 ILE A  88
LEU A 121
HIS A  10
ALA A  28
 None
 1.01A 6ck2C-5mewA:
undetectable
6ck2D-5mewA:
undetectable		 6ck2C-5mewA:
3.83
6ck2D-5mewA:
5.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5myv SRSF PROTEIN KINASE
2,SRSF PROTEIN
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		4 ILE A 568
LEU A 641
HIS A 609
ALA A 611
 None
 0.87A 6ck2C-5myvA:
undetectable
6ck2D-5myvA:
undetectable		 6ck2C-5myvA:
4.63
6ck2D-5myvA:
7.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osn CAPSID PROTEIN

(Enterovirus E) 		PF00073
(Rhv) 		4 ILE B 207
LEU B 204
HIS B 170
ALA B 124
 None
 1.05A 6ck2C-5osnB:
undetectable
6ck2D-5osnB:
undetectable		 6ck2C-5osnB:
8.15
6ck2D-5osnB:
7.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj6 HIGH CONDUCTANCE
CALCIUM-ACTIVATED
POTASSIUM CHANNEL

(Aplysia
californica) 		PF00520
(Ion_trans)
PF03493
(BK_channel_a) 		4 ILE A 282
LEU A 270
HIS A 243
ALA A 239
 None
 0.99A 6ck2C-5tj6A:
undetectable
6ck2D-5tj6A:
undetectable		 6ck2C-5tj6A:
4.31
6ck2D-5tj6A:
3.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xv7 SERINE-ARGININE (SR)
PROTEIN KINASE 1

(Homo sapiens) 		no annotation 4 ILE A 524
LEU A 597
HIS A 565
ALA A 567
 None
 0.98A 6ck2C-5xv7A:
undetectable
6ck2D-5xv7A:
undetectable		 6ck2C-5xv7A:
undetectable
6ck2D-5xv7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xzb CYCLIC GMP-AMP
SYNTHASE

(Mus musculus) 		PF03281
(Mab-21) 		4 ILE A 493
LEU A 452
HIS A 422
ALA A 426
 None
None
A9Y  A 602 ( 4.5A)
None
 0.99A 6ck2C-5xzbA:
undetectable
6ck2D-5xzbA:
undetectable		 6ck2C-5xzbA:
3.71
6ck2D-5xzbA:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b2y SOLUTE-BINDING
PERIPLASMIC PROTEIN
OF IRON/SIDEROPHORE
ABC TRANSPORTER

(Yersinia pestis) 		no annotation 4 ILE A 239
LEU A 268
HIS A 287
ALA A 346
 None
 0.97A 6ck2C-6b2yA:
undetectable
6ck2D-6b2yA:
undetectable		 6ck2C-6b2yA:
4.79
6ck2D-6b2yA:
6.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3b APRA
METHYLTRANSFERASE 1

(Moorea
bouillonii) 		no annotation 4 ILE A 517
LEU A 555
HIS A 546
ALA A 558
 None
 0.99A 6ck2C-6b3bA:
undetectable
6ck2D-6b3bA:
undetectable		 6ck2C-6b3bA:
2.49
6ck2D-6b3bA:
5.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6y APRA
METHYLTRANSFERASE 2

(Moorea
bouillonii) 		no annotation 4 ILE A 517
LEU A 555
HIS A 546
ALA A 558
 None
 0.80A 6ck2C-6d6yA:
undetectable
6ck2D-6d6yA:
undetectable		 6ck2C-6d6yA:
undetectable
6ck2D-6d6yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6pax HOMEOBOX PROTEIN
PAX-6

(Homo sapiens) 		PF00292
(PAX) 		4 ILE A  63
LEU A  54
HIS A  31
ALA A  30
 None
 0.93A 6ck2C-6paxA:
undetectable
6ck2D-6paxA:
undetectable		 6ck2C-6paxA:
9.52
6ck2D-6paxA:
19.48