SIMILAR PATTERNS OF AMINO ACIDS FOR 6CI6_A_NBOA607_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aep APOLIPOPHORIN III

(Locusta
migratoria) 		no annotation 4 ASN A  46
ALA A  47
LYS A  51
GLU A  54
 None
 1.03A 6ci6A-1aepA:
1.6		 6ci6A-1aepA:
16.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1coo RNA POLYMERASE ALPHA
SUBUNIT

(Escherichia
coli) 		PF03118
(RNA_pol_A_CTD) 		4 ASP A 258
ASN A 268
ALA A 267
GLU A 261
 None
 0.94A 6ci6A-1cooA:
undetectable		 6ci6A-1cooA:
19.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fvp FLAVOPROTEIN 390

(Photobacterium
phosphoreum) 		no annotation 4 ASN A 111
ALA A 112
GLU A  79
LEU A 107
 None
 1.00A 6ci6A-1fvpA:
undetectable		 6ci6A-1fvpA:
25.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1g3r CELL DIVISION
INHIBITOR

(Pyrococcus
furiosus) 		PF13614
(AAA_31) 		4 ALA A  64
LYS A  95
GLU A  91
LEU A  41
 None
 1.03A 6ci6A-1g3rA:
undetectable		 6ci6A-1g3rA:
13.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gk2 HISTIDINE
AMMONIA-LYASE

(Pseudomonas
putida) 		PF00221
(Lyase_aromatic) 		4 ASN A 433
ALA A 392
GLU A 347
LEU A 398
 None
 1.04A 6ci6A-1gk2A:
1.3		 6ci6A-1gk2A:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hsj FUSION PROTEIN
CONSISTING OF
STAPHYLOCOCCUS
ACCESSORY REGULATOR
PROTEIN R AND
MALTOSE BINDING
PROTEIN

(Escherichia
coli;
Staphylococcus
aureus) 		PF01547
(SBP_bac_1) 		4 ASP A 358
ALA A 362
LYS A 189
LEU A 192
 None
 1.08A 6ci6A-1hsjA:
0.0		 6ci6A-1hsjA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htt HISTIDYL-TRNA
SYNTHETASE

(Escherichia
coli) 		PF03129
(HGTP_anticodon)
PF13393
(tRNA-synt_His) 		4 ASP A  61
LYS A  53
GLU A  58
LEU A 261
 None
None
None
AMP  A 451 (-4.6A)
 0.97A 6ci6A-1httA:
0.0		 6ci6A-1httA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i8q HYALURONATE LYASE

(Streptococcus
agalactiae) 		PF02278
(Lyase_8)
PF02884
(Lyase_8_C)
PF08124
(Lyase_8_N) 		4 ASP A 889
ASN A 778
ALA A 761
LYS A 763
 None
 1.00A 6ci6A-1i8qA:
0.0		 6ci6A-1i8qA:
7.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyh HYPOTHETICAL 29.9
KDA PROTEIN IN
SIGY-CYDD INTERGENIC
REGION

(Bacillus
subtilis) 		PF01256
(Carb_kinase) 		4 ASN A 238
ALA A 235
GLU A 230
LEU A  15
 None
 1.07A 6ci6A-1kyhA:
1.6		 6ci6A-1kyhA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1l RIBONUCLEOSIDE
TRIPHOSPHATE
REDUCTASE

(Lactobacillus
leichmannii) 		PF02867
(Ribonuc_red_lgC) 		4 ALA A 615
LYS A 695
GLU A 699
LEU A 571
 None
 0.87A 6ci6A-1l1lA:
0.0		 6ci6A-1l1lA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1of9 PORE-FORMING PEPTIDE
AMEOBAPORE A

(Entamoeba
histolytica) 		PF03489
(SapB_2) 		4 ALA A  76
LYS A   1
GLU A   2
LEU A   7
 None
 1.01A 6ci6A-1of9A:
4.2		 6ci6A-1of9A:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ppr PERIDININ-CHLOROPHYL
L PROTEIN

(Amphidinium
carterae) 		PF02429
(PCP) 		4 ASP M  86
ASN M  89
ALA M  90
LEU M  10
 None
PID  M 614 (-4.0A)
None
CLA  M 601 ( 4.9A)
 0.96A 6ci6A-1pprM:
1.7		 6ci6A-1pprM:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qag UTROPHIN ACTIN
BINDING REGION

(Homo sapiens) 		PF00307
(CH) 		4 ASN A  92
ALA A  89
LYS A  61
LEU A  67
 None
 1.04A 6ci6A-1qagA:
undetectable		 6ci6A-1qagA:
17.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t1s 1-DEOXY-D-XYLULOSE
5-PHOSPHATE
REDUCTOISOMERASE

(Escherichia
coli) 		PF02670
(DXP_reductoisom)
PF08436
(DXP_redisom_C)
PF13288
(DXPR_C) 		4 ASP A 149
ALA A 122
LYS A 124
LEU A 127
 MG  A1002 ( 3.3A)
None
CBQ  A2001 ( 3.1A)
None
 0.86A 6ci6A-1t1sA:
undetectable		 6ci6A-1t1sA:
13.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tv8 MOLYBDENUM COFACTOR
BIOSYNTHESIS PROTEIN
A

(Staphylococcus
aureus) 		PF04055
(Radical_SAM)
PF06463
(Mob_synth_C)
PF13394
(Fer4_14) 		4 ALA A  63
LYS A  68
GLU A  97
LEU A  90
 None
 1.01A 6ci6A-1tv8A:
undetectable		 6ci6A-1tv8A:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wd3 ALPHA-L-ARABINOFURAN
OSIDASE B

(Aspergillus
kawachii) 		PF05270
(AbfB)
PF09206
(ArabFuran-catal) 		4 ASP A 427
ASN A 426
ALA A 425
LEU A 396
 None
 1.01A 6ci6A-1wd3A:
undetectable		 6ci6A-1wd3A:
9.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yfm FUMARASE

(Saccharomyces
cerevisiae) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		4 ASN A 194
ALA A 195
LYS A 199
GLU A 202
 None
 0.98A 6ci6A-1yfmA:
2.9		 6ci6A-1yfmA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yp4 GLUCOSE-1-PHOSPHATE
ADENYLYLTRANSFERASE
SMALL SUBUNIT

(Solanum
tuberosum) 		PF00483
(NTP_transferase) 		4 ASN A 291
ALA A 290
GLU A 285
LEU A 365
 None
 1.09A 6ci6A-1yp4A:
undetectable		 6ci6A-1yp4A:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2avf COPPER-CONTAINING
NITRITE REDUCTASE

(Achromobacter
cycloclastes) 		PF00394
(Cu-oxidase)
PF07732
(Cu-oxidase_3) 		4 ALA A  61
LYS A  48
GLU A  46
LEU A  93
 None
 1.06A 6ci6A-2avfA:
undetectable		 6ci6A-2avfA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bex RIBONUCLEASE
INHIBITOR

(Homo sapiens) 		PF13516
(LRR_6) 		4 ALA A  58
LYS A  88
GLU A 116
LEU A 111
 None
 0.89A 6ci6A-2bexA:
undetectable		 6ci6A-2bexA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1c CARBOXYPEPTIDASE B

(Helicoverpa zea) 		PF00246
(Peptidase_M14) 		4 ASP A 209
ALA A 244
GLU A 255
LEU A 212
 None
 0.98A 6ci6A-2c1cA:
undetectable		 6ci6A-2c1cA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cvz 3-HYDROXYISOBUTYRATE
DEHYDROGENASE

(Thermus
thermophilus) 		PF03446
(NAD_binding_2)
PF14833
(NAD_binding_11) 		4 ASN A 169
ALA A 166
LYS A 234
LEU A 232
 None
None
NDP  A1302 (-2.9A)
None
 1.07A 6ci6A-2cvzA:
undetectable		 6ci6A-2cvzA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk0 D-PSICOSE
3-EPIMERASE

(Agrobacterium
tumefaciens) 		PF01261
(AP_endonuc_2) 		4 ASP A 275
ASN A 278
ALA A 279
GLU A 212
 ASP  A 275 ( 0.6A)
ASN  A 278 ( 0.6A)
ALA  A 279 ( 0.0A)
GLU  A 212 ( 0.6A)
 0.84A 6ci6A-2hk0A:
undetectable		 6ci6A-2hk0A:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j63 AP-ENDONUCLEASE

(Leishmania
major) 		PF03372
(Exo_endo_phos) 		4 ASP A 191
ASN A 178
ALA A 175
LEU A 181
 None
 0.98A 6ci6A-2j63A:
undetectable		 6ci6A-2j63A:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjm GLYCOSYL
TRANSFERASE, GROUP 1
FAMILY PROTEIN

(Bacillus
anthracis) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		4 ALA A  73
LYS A  77
GLU A  80
LEU A 104
 None
 1.07A 6ci6A-2jjmA:
undetectable		 6ci6A-2jjmA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nlz CEPHALOSPORIN
ACYLASE

(Bacillus
halodurans) 		PF01019
(G_glu_transpept) 		4 ASP A 226
ALA A 230
LYS A 241
LEU A 244
 None
 0.89A 6ci6A-2nlzA:
undetectable		 6ci6A-2nlzA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v1u CELL DIVISION
CONTROL PROTEIN 6
HOMOLOG

(Aeropyrum
pernix) 		PF09079
(Cdc6_C)
PF13191
(AAA_16) 		4 ASP A 392
ALA A 396
GLU A 386
LEU A 306
 None
 1.00A 6ci6A-2v1uA:
2.2		 6ci6A-2v1uA:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vd3 ATP
PHOSPHORIBOSYLTRANSF
ERASE

(Methanothermobacter
thermautotrophicus) 		PF01634
(HisG)
PF08029
(HisG_C) 		4 ASP A  65
ASN A 187
ALA A 186
GLU A 199
 MPD  A1300 (-2.7A)
None
None
None
 1.00A 6ci6A-2vd3A:
undetectable		 6ci6A-2vd3A:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vr5 GLYCOGEN OPERON
PROTEIN GLGX

(Sulfolobus
solfataricus) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		4 ASP A 308
ASN A  39
ALA A  40
LEU A  97
 None
 1.10A 6ci6A-2vr5A:
undetectable		 6ci6A-2vr5A:
7.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 ASP A 168
ALA A 166
GLU A 515
LEU A 444
 None
FAD  A 601 (-3.2A)
None
None
 1.05A 6ci6A-2wu5A:
undetectable		 6ci6A-2wu5A:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wy0 ANGIOTENSINOGEN

(Mus musculus) 		PF00079
(Serpin) 		4 ASP C 321
ALA C 325
LYS C  86
GLU C  90
 None
EDO  C1455 ( 4.3A)
None
None
 0.76A 6ci6A-2wy0C:
undetectable		 6ci6A-2wy0C:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Bovine leukemia
virus;
Escherichia
coli) 		PF00429
(TLV_coat)
PF13416
(SBP_bac_8) 		4 ASP A 384
ALA A 388
LYS A 215
LEU A 218
 None
 0.98A 6ci6A-2xz3A:
undetectable		 6ci6A-2xz3A:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3biw NEUROLIGIN-1

(Rattus
norvegicus) 		PF00135
(COesterase) 		4 ASP A 522
ALA A 524
LYS A 414
GLU A 417
 None
 0.89A 6ci6A-3biwA:
2.6		 6ci6A-3biwA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3j PUTATIVE
TAGATOSE-6-PHOSPHATE
KETOSE/ALDOSE
ISOMERASE

(Escherichia
coli) 		PF01380
(SIS) 		4 ALA A 243
LYS A 245
GLU A 248
LEU A 254
 None
 1.10A 6ci6A-3c3jA:
undetectable		 6ci6A-3c3jA:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dcl TM1086

(Thermotoga
maritima) 		PF14505
(DUF4438) 		4 ASP A 215
ASN A 275
ALA A 274
GLU A 272
 None
 0.97A 6ci6A-3dclA:
undetectable		 6ci6A-3dclA:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e2n CYTOCHROME C
PEROXIDASE

(Pisum sativum;
Saccharomyces
cerevisiae) 		PF00141
(peroxidase) 		4 ASN A  24
ALA A  25
LYS A  29
GLU A  32
 None
 0.87A 6ci6A-3e2nA:
undetectable		 6ci6A-3e2nA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ele AMINO TRANSFERASE

([Eubacterium]
rectale) 		PF00155
(Aminotran_1_2) 		4 ASN A 345
ALA A 346
LYS A 350
GLU A 353
 None
 0.91A 6ci6A-3eleA:
undetectable		 6ci6A-3eleA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6q LIM AND SENESCENT
CELL
ANTIGEN-LIKE-CONTAIN
ING DOMAIN PROTEIN 1

(Homo sapiens) 		PF00412
(LIM) 		4 ASN B  25
LYS B  22
GLU B  33
LEU B  30
 None
 0.82A 6ci6A-3f6qB:
undetectable		 6ci6A-3f6qB:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6e MUCONATE
CYCLOISOMERASE I

(Ruegeria
pomeroyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ALA A  72
GLU A 105
LYS A 107
LEU A 110
 None
 1.06A 6ci6A-3i6eA:
undetectable		 6ci6A-3i6eA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6t MUCONATE
CYCLOISOMERASE

(Jannaschia sp.
CCS1) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 ALA A  70
GLU A 103
LYS A 105
LEU A 108
 None
 1.07A 6ci6A-3i6tA:
undetectable		 6ci6A-3i6tA:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Saccharomyces
cerevisiae) 		no annotation 4 ASP B 505
ALA B 502
GLU B  25
LEU B 510
 None
 1.07A 6ci6A-3kx2B:
undetectable		 6ci6A-3kx2B:
6.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3la8 PUTATIVE PURINE
NUCLEOSIDE
PHOSPHORYLASE

(Streptococcus
mutans) 		PF01048
(PNP_UDP_1) 		4 ASN A 137
ALA A 136
LYS A  89
LEU A 139
 None
 1.06A 6ci6A-3la8A:
undetectable		 6ci6A-3la8A:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcp GLUCOKINASE

(Parabacteroides
distasonis) 		PF00480
(ROK) 		4 ASN A 283
ALA A 284
GLU A 244
LEU A 279
 None
 1.01A 6ci6A-3mcpA:
2.4		 6ci6A-3mcpA:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmt FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Bartonella
henselae) 		PF00274
(Glycolytic) 		4 ASN A 280
ALA A 281
GLU A 239
LEU A 276
 None
 1.01A 6ci6A-3mmtA:
undetectable		 6ci6A-3mmtA:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzp ARGININE
DECARBOXYLASE

(Campylobacter
jejuni) 		PF02784
(Orn_Arg_deC_N) 		4 ASP A 401
ASN A 404
ALA A 405
GLU A 361
 None
 0.89A 6ci6A-3nzpA:
undetectable		 6ci6A-3nzpA:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3o ALPHA-SUBUNIT
2-HYDROXYISOCAPROYL-
COA DEHYDRATASE

(Clostridioides
difficile) 		PF06050
(HGD-D) 		4 ASN A  90
ALA A  87
GLU A  75
LEU A  93
 None
 0.77A 6ci6A-3o3oA:
1.2		 6ci6A-3o3oA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ocd SOXA

(Starkeya
novella) 		no annotation 5 ASP A 138
ASN A  52
ALA A 141
GLU A  57
LEU A  51
 None
 1.24A 6ci6A-3ocdA:
undetectable		 6ci6A-3ocdA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxp HELIX-TURN-HELIX
DOMAIN PROTEIN

(Chloroflexus
aurantiacus) 		PF13560
(HTH_31) 		4 ASN A 176
ALA A 173
GLU A 216
LEU A 179
 MYR  A 301 (-3.1A)
None
None
None
 1.02A 6ci6A-3pxpA:
undetectable		 6ci6A-3pxpA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9c ACETYLPOLYAMINE
AMIDOHYDROLASE

(Mycoplana
ramosa) 		PF00850
(Hist_deacetyl) 		4 ASP A 140
ALA A 144
LYS A 184
LEU A 181
 None
 0.78A 6ci6A-3q9cA:
undetectable		 6ci6A-3q9cA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rmr AVIRULENCE PROTEIN

(Hyaloperonospora
parasitica) 		no annotation 4 ASP A 213
ASN A 217
ALA A 215
GLU A 210
 None
 1.07A 6ci6A-3rmrA:
2.7		 6ci6A-3rmrA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t8j PURINE NUCLEOSIDASE,
(IUNH-1)

(Sulfolobus
solfataricus) 		PF01156
(IU_nuc_hydro) 		4 ALA A  96
LYS A  45
GLU A  90
LEU A  51
 None
 0.94A 6ci6A-3t8jA:
undetectable		 6ci6A-3t8jA:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfx OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Lactobacillus
acidophilus) 		PF00215
(OMPdecase) 		4 ASN A 235
ALA A 236
LYS A 201
GLU A 205
 None
 1.05A 6ci6A-3tfxA:
undetectable		 6ci6A-3tfxA:
16.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tpa HEME-BINDING PROTEIN
A

(Glaesserella
parasuis) 		PF00496
(SBP_bac_5) 		4 ASN A 150
ALA A 453
LYS A 148
LEU A 146
 None
 0.96A 6ci6A-3tpaA:
2.7		 6ci6A-3tpaA:
9.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3udu 3-ISOPROPYLMALATE
DEHYDROGENASE

(Campylobacter
jejuni) 		PF00180
(Iso_dh) 		4 ASP A 315
ASN A 318
ALA A 319
GLU A 354
 None
 0.77A 6ci6A-3uduA:
undetectable		 6ci6A-3uduA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ujp MN TRANSPORTER
SUBUNIT

(Synechocystis
sp. PCC 6803) 		PF01297
(ZnuA) 		4 ASP A 179
ASN A 180
ALA A 181
GLU A 175
 CAC  A2327 (-2.8A)
None
None
None
 0.91A 6ci6A-3ujpA:
1.9		 6ci6A-3ujpA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgs NUCLEOSIDE
DIPHOSPHATE KINASE

(Halomonas sp.
#593) 		PF00334
(NDK) 		4 ASN A  86
ALA A  84
GLU A  80
LEU A  77
 None
 0.97A 6ci6A-3vgsA:
undetectable		 6ci6A-3vgsA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtz GLUCOSE
1-DEHYDROGENASE

(Thermoplasma
volcanium) 		PF13561
(adh_short_C2) 		4 ASN A 195
ALA A 196
LYS A 200
GLU A 203
 None
 0.99A 6ci6A-3vtzA:
undetectable		 6ci6A-3vtzA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0z ANCILLARY PROTEIN 2

(Streptococcus
pyogenes) 		PF08341
(TED) 		4 ASP A 129
ASN A 132
ALA A 133
LEU A 166
 None
 0.96A 6ci6A-4c0zA:
undetectable		 6ci6A-4c0zA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dal PUTATIVE ALDEHYDE
DEHYDROGENASE

(Sinorhizobium
meliloti) 		PF00171
(Aldedh) 		4 ASP A  79
ALA A  83
LYS A  97
LEU A 101
 None
 0.77A 6ci6A-4dalA:
undetectable		 6ci6A-4dalA:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jc8 HOPS COMPONENT VPS33

(Chaetomium
thermophilum) 		PF00995
(Sec1) 		4 ASN A 316
ALA A 315
GLU A 253
LEU A 250
 None
 1.09A 6ci6A-4jc8A:
3.1		 6ci6A-4jc8A:
8.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ksi LEUCINE
AMINOPEPTIDASE 1,
CHLOROPLASTIC

(Solanum
lycopersicum) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		4 ASP A 436
ALA A 396
GLU A 429
LEU A 308
 None
None
MG  A 601 (-2.3A)
None
 0.91A 6ci6A-4ksiA:
undetectable		 6ci6A-4ksiA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n58 PECTOCIN M2

(Pectobacterium
carotovorum) 		PF00111
(Fer2)
PF14859
(Colicin_M) 		4 LYS A 266
GLU A 218
LYS A 264
LEU A 263
 None
None
None
SO4  A 307 ( 4.4A)
 0.93A 6ci6A-4n58A:
undetectable		 6ci6A-4n58A:
14.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2x MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ATP-DEPENDENT CLP
PROTEASE ADAPTOR
PROTEIN CLPS
CONTAINING PROTEIN
CHIMERIC CONSTRUCT

(Escherichia
coli;
Plasmodium
falciparum) 		PF02617
(ClpS)
PF13416
(SBP_bac_8) 		4 ASP A 359
ALA A 363
LYS A 190
LEU A 193
 None
 1.07A 6ci6A-4o2xA:
2.1		 6ci6A-4o2xA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozq CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND KINESIN FAMILY
MEMBER 14 PROTEIN

(Escherichia
coli;
Mus musculus) 		PF00225
(Kinesin)
PF13416
(SBP_bac_8) 		4 ASP A -12
ALA A  -8
LYS A-181
LEU A-178
 None
 1.07A 6ci6A-4ozqA:
undetectable		 6ci6A-4ozqA:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pki GELSOLIN,TROPOMODULI
N-1 CHIMERA

(Homo sapiens) 		PF00626
(Gelsolin) 		4 ALA G1217
LYS G1221
GLU G1250
LEU G1254
 None
 0.88A 6ci6A-4pkiG:
undetectable		 6ci6A-4pkiG:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pwt PEPTIDOGLYCAN-ASSOCI
ATED LIPOPROTEIN

(Yersinia pestis) 		PF00691
(OmpA) 		4 ASP A  84
ALA A  88
LYS A 131
LEU A 128
 None
 0.91A 6ci6A-4pwtA:
undetectable		 6ci6A-4pwtA:
17.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qyj ALDEHYDE
DEHYDROGENASE

(Pseudomonas
putida) 		PF00171
(Aldedh) 		4 ALA A 175
LYS A 178
GLU A 477
LEU A 123
 None
 1.02A 6ci6A-4qyjA:
undetectable		 6ci6A-4qyjA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r2g SURFACE PROTEIN
GP160

(Human
immunodeficiency
virus 1) 		no annotation 4 ASN E 339
ALA E 336
GLU E 290
LEU E 342
 NAG  E 514 (-2.4A)
NAG  E 514 ( 4.6A)
None
None
 1.05A 6ci6A-4r2gE:
undetectable		 6ci6A-4r2gE:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upe NICKEL-DEPENDENT
HYDROGENASE LARGE
SUBUNIT

(Desulfovibrio
fructosivorans) 		PF00374
(NiFeSe_Hases) 		4 ASN Q 250
ALA Q 249
GLU Q 440
LEU Q 254
 None
 1.08A 6ci6A-4upeQ:
undetectable		 6ci6A-4upeQ:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yn5 MANNAN
ENDO-1,4-BETA-MANNOS
IDASE

(Bacillus sp.
JAMB750) 		PF02156
(Glyco_hydro_26) 		4 ASP A 186
ALA A 190
LYS A 246
LEU A 242
 None
 0.93A 6ci6A-4yn5A:
undetectable		 6ci6A-4yn5A:
12.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zg8 ENDOGLUCANASE

(Perinereis
brevicirris) 		PF00759
(Glyco_hydro_9) 		4 ASP A 209
ASN A 206
ALA A 207
GLU A 202
 None
None
None
NA  A 506 (-3.4A)
 1.08A 6ci6A-4zg8A:
undetectable		 6ci6A-4zg8A:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c79 ARF-GAP

(Mus musculus) 		PF00169
(PH) 		4 ALA A 363
LYS A 365
GLU A 341
LEU A 426
 None
 0.97A 6ci6A-5c79A:
undetectable		 6ci6A-5c79A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cbm M17 FAMILY
AMINOPEPTIDASE

(Plasmodium
falciparum) 		PF00883
(Peptidase_M17) 		4 ASP A 468
ALA A 428
GLU A 461
LEU A 342
 None
None
ZN  A 703 ( 2.5A)
None
 0.91A 6ci6A-5cbmA:
undetectable		 6ci6A-5cbmA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cvo WD REPEAT-CONTAINING
PROTEIN 48

(Homo sapiens) 		PF00400
(WD40) 		5 ASN A  34
ALA A  48
GLU A 301
LYS A 299
LEU A 298
 None
 1.21A 6ci6A-5cvoA:
undetectable		 6ci6A-5cvoA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6h CSUC

(Acinetobacter
baumannii) 		PF00345
(PapD_N) 		4 ASP A 208
ALA A 212
GLU A 162
LEU A 189
 None
 1.04A 6ci6A-5d6hA:
undetectable		 6ci6A-5d6hA:
17.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5dqf SERUM ALBUMIN

(Equus caballus) 		PF00273
(Serum_albumin) 		6 ASP A 401
ASN A 404
ALA A 405
LYS A 540
GLU A 541
LEU A 547
 CL  A 615 ( 3.8A)
None
None
SO4  A 609 (-4.0A)
SO4  A 609 (-3.9A)
None
 0.52A 6ci6A-5dqfA:
51.9		 6ci6A-5dqfA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dzq TOXIN-LIKE PROTEIN

(Paenibacillus
larvae) 		PF03496
(ADPrib_exo_Tox) 		4 ASN A  17
ALA A  16
GLU A  11
LEU A  21
 None
 0.88A 6ci6A-5dzqA:
undetectable		 6ci6A-5dzqA:
17.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fo1 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF

(Corynebacterium
ammoniagenes) 		PF01687
(Flavokinase)
PF06574
(FAD_syn) 		4 ASN A  36
ALA A  37
LYS A  41
GLU A  44
 None
 1.00A 6ci6A-5fo1A:
undetectable		 6ci6A-5fo1A:
13.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,APOPTOSIS-AS
SOCIATED SPECK-LIKE
PROTEIN CONTAINING A
CARD

(Danio rerio;
Escherichia
coli) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		4 ASP A 359
ALA A 363
LYS A 190
LEU A 193
 None
 1.08A 6ci6A-5gpqA:
undetectable		 6ci6A-5gpqA:
13.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hql RIBULOSE
BISPHOSPHATE
CARBOXYLASE

(Rhodopseudomonas
palustris) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 ASP A 254
ASN A 255
ALA A 256
GLU A 250
 None
 0.69A 6ci6A-5hqlA:
undetectable		 6ci6A-5hqlA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN

(Escherichia
coli;
Homo sapiens) 		PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8) 		4 ASP A 725
ALA A 729
LYS A 556
LEU A 559
 None
 0.94A 6ci6A-5hzvA:
undetectable		 6ci6A-5hzvA:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hzw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ENDOGLIN

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8) 		4 ASP A 413
ALA A 417
LYS A 244
LEU A 247
 None
 1.03A 6ci6A-5hzwA:
2.6		 6ci6A-5hzwA:
8.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it5 ATP BINDING
MOTIF-CONTAINING
PROTEIN PILF

(Thermus
thermophilus) 		no annotation 4 ASP F 747
ALA F 851
GLU F 856
LEU F 835
 None
 1.09A 6ci6A-5it5F:
undetectable		 6ci6A-5it5F:
11.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iy9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Homo sapiens) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 ASP A1249
ASN A1251
ALA A1252
GLU A1188
 None
 1.08A 6ci6A-5iy9A:
2.1		 6ci6A-5iy9A:
3.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jd4 LAE6

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		4 ASP A 303
ALA A 307
LYS A 109
LEU A 106
 PE3  A 406 ( 4.6A)
None
None
None
 1.02A 6ci6A-5jd4A:
undetectable		 6ci6A-5jd4A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzi HCV1406 TCR ALPHA
CHAIN

(Homo sapiens) 		PF07686
(V-set)
PF09291
(DUF1968) 		4 ASN D  63
ALA D  64
LYS D  60
GLU D  57
 None
 0.93A 6ci6A-5jziD:
undetectable		 6ci6A-5jziD:
16.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kis RHS2

(Yersinia
entomophaga) 		no annotation 4 ASP B 348
ASN B 347
GLU B 335
LEU B 332
 None
 1.05A 6ci6A-5kisB:
undetectable		 6ci6A-5kisB:
8.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mju EXCITATORY AMINO
ACID TRANSPORTER
1,NEUTRAL AMINO ACID
TRANSPORTER
B(0),EXCITATORY
AMINO ACID
TRANSPORTER 1

(Homo sapiens) 		PF00375
(SDF) 		4 ALA A  82
LYS A 280
GLU A 283
LEU A  68
 None
 0.81A 6ci6A-5mjuA:
undetectable		 6ci6A-5mjuA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mu7 COATOMER SUBUNIT
BETA

(Chaetomium
thermophilum) 		PF01602
(Adaptin_N) 		4 ALA A 279
LYS A 283
GLU A 286
LEU A 315
 None
 1.09A 6ci6A-5mu7A:
2.1		 6ci6A-5mu7A:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nl6 CALPONIN DOMAIN
FAMILY PROTEIN

(Entamoeba
histolytica) 		no annotation 4 ASN A 381
ALA A 382
LYS A 386
GLU A 389
 None
 1.02A 6ci6A-5nl6A:
undetectable		 6ci6A-5nl6A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5i TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT B
TUNGSTEN
FORMYLMETHANOFURAN
DEHYDROGENASE
SUBUNIT FWDD

(Methanothermobacter
sp. CaT2;
Methanothermobacter
wolfeii) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 ASN B 327
ALA D  96
GLU B 323
LEU B 330
 None
 1.09A 6ci6A-5t5iB:
undetectable		 6ci6A-5t5iB:
9.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tgd FOLM ALTERNATIVE
DIHYDROFOLATE
REDUCTASE

(Brucella suis) 		PF00106
(adh_short) 		4 ASP A 116
ALA A 114
LYS A 111
GLU A 109
 None
 1.07A 6ci6A-5tgdA:
undetectable		 6ci6A-5tgdA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u9e HTH-TYPE
TRANSCRIPTIONAL
ACTIVATOR RHAR

(Bacteria
Latreille et
al. 1825) 		no annotation 4 ASP A  37
ALA A  70
LYS A   6
LEU A   7
 None
None
None
RM4  A 201 (-4.5A)
 1.04A 6ci6A-5u9eA:
undetectable		 6ci6A-5u9eA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uag DNA-DIRECTED RNA
POLYMERASE SUBUNIT
ALPHA

(Escherichia
coli) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L) 		4 ASP A 197
ALA A 189
LYS A 200
GLU A  29
 None
 1.06A 6ci6A-5uagA:
undetectable		 6ci6A-5uagA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ucc POTENTIAL EPSIN-LIKE
CLATHRIN-BINDING
PROTEIN

(Candida
albicans) 		PF01417
(ENTH) 		4 ASN A 145
ALA A 144
LYS A 140
GLU A 137
 None
 1.05A 6ci6A-5uccA:
undetectable		 6ci6A-5uccA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uyt ICE-BINDING PROTEIN

(Flavobacteriaceae
bacterium
3519-10) 		no annotation 4 ASP A 396
ASN A 395
LYS A 399
GLU A 418
 None
 1.00A 6ci6A-5uytA:
undetectable		 6ci6A-5uytA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y35 -

(-) 		no annotation 4 ASP B 221
ALA B   3
LYS B   5
LEU B 224
 None
 0.90A 6ci6A-5y35B:
undetectable		 6ci6A-5y35B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d8w HEMAGGLUTININ

(Influenza A
virus) 		no annotation 4 ALA A  60
GLU A 101
LYS A 104
LEU A 107
 None
None
OXM  A 503 (-3.6A)
None
 0.87A 6ci6A-6d8wA:
undetectable		 6ci6A-6d8wA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL

(Trypanosoma
brucei) 		no annotation 4 ASN A 158
ALA A 391
GLU A 178
LEU A 160
 None
 0.63A 6ci6A-6f5dA:
undetectable		 6ci6A-6f5dA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fhv GLUCOAMYLASE

(Penicillium
oxalicum) 		no annotation 4 ASP A 299
ASN A 479
ALA A 475
GLU A 295
 None
 1.01A 6ci6A-6fhvA:
undetectable		 6ci6A-6fhvA:
19.51