SIMILAR PATTERNS OF AMINO ACIDS FOR 6CE2_B_SVRB202_2
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1bgc | GRANULOCYTECOLONY-STIMULATINGFACTOR (Bos taurus) |
PF16647(GCSF) | 5 | LEU A 172LEU A 169GLY A 74GLY A 126PRO A 11 | None | 1.05A | 6ce2B-1bgcA:undetectable | 6ce2B-1bgcA:20.12 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1bpq | PHOSPHOLIPASE A2 (Bos taurus) |
PF00068(Phospholip_A2_1) | 5 | LEU A 2GLY A 30GLY A 32TYR A 52PRO A 68 | None CA A 124 (-4.2A) CA A 124 (-4.2A)NoneNone | 0.93A | 6ce2B-1bpqA:17.6 | 6ce2B-1bpqA:37.40 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1bun | BETA2-BUNGAROTOXIN (Bungarusmulticinctus) |
PF00068(Phospholip_A2_1) | 6 | GLY A 30GLY A 32TYR A 52ASN A 62PRO A 63LYS A 64 | NA A 121 (-4.4A) NA A 121 (-3.8A)NoneNoneNoneNone | 1.00A | 6ce2B-1bunA:16.4 | 6ce2B-1bunA:37.30 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1bun | BETA2-BUNGAROTOXIN (Bungarusmulticinctus) |
PF00068(Phospholip_A2_1) | 6 | LEU A 2GLY A 32TYR A 52ASN A 62PRO A 63LYS A 64 | None NA A 121 (-3.8A)NoneNoneNoneNone | 0.93A | 6ce2B-1bunA:16.4 | 6ce2B-1bunA:37.30 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1cvr | GINGIPAIN R (Porphyromonasgingivalis) |
PF01364(Peptidase_C25)PF03785(Peptidase_C25_C) | 5 | LEU A 345GLY A 35ARG A 11TYR A 72PRO A 342 | None | 1.13A | 6ce2B-1cvrA:undetectable | 6ce2B-1cvrA:13.69 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1dpy | PHOSPHOLIPASE A2 (Bungaruscaeruleus) |
PF00068(Phospholip_A2_1) | 5 | GLY A 30GLY A 32TYR A 52ASN A 62PRO A 63 | NA A 150 (-4.5A) NA A 150 (-4.5A)NoneNoneNone | 1.03A | 6ce2B-1dpyA:16.8 | 6ce2B-1dpyA:36.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1esc | ESTERASE (Streptomycesscabiei) |
PF13472(Lipase_GDSL_2) | 5 | LEU A 220LEU A 217GLY A 263ARG A 260PRO A 191 | None | 1.06A | 6ce2B-1escA:undetectable | 6ce2B-1escA:18.09 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1g0z | PHOSPHOLIPASE A2 (Bungaruscaeruleus) |
PF00068(Phospholip_A2_1) | 5 | GLY A 30GLY A 32TYR A 52ASN A 62PRO A 63 | None | 0.95A | 6ce2B-1g0zA:16.5 | 6ce2B-1g0zA:34.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1gju | MALTODEXTRINGLYCOSYLTRANSFERASE (Thermotogamaritima) |
PF00128(Alpha-amylase)PF09083(DUF1923) | 5 | LEU A 433LEU A 461GLY A 381ARG A 197PRO A 459 | None | 1.14A | 6ce2B-1gjuA:undetectable | 6ce2B-1gjuA:10.69 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1lkf | LEUKOCIDIN F SUBUNIT (Staphylococcusaureus) |
PF07968(Leukocidin) | 5 | LEU A 36GLY A 2TYR A 245ASN A 222PRO A 223 | None | 1.06A | 6ce2B-1lkfA:undetectable | 6ce2B-1lkfA:14.97 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1mc2 | ACUTOHAEMONLYSIN (Deinagkistrodonacutus) |
PF00068(Phospholip_A2_1) | 6 | LEU A1002GLY A1023GLY A1030GLY A1033ARG A1034LYS A1049 | IPA A1136 ( 4.7A)IPA A1135 ( 4.1A)IPA A1135 ( 4.4A)NoneNoneNone | 1.27A | 6ce2B-1mc2A:22.7 | 6ce2B-1mc2A:72.13 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1mc2 | ACUTOHAEMONLYSIN (Deinagkistrodonacutus) |
PF00068(Phospholip_A2_1) | 5 | LEU A1002GLY A1023GLY A1030GLY A1033LYS A1049 | IPA A1136 ( 4.7A)IPA A1135 ( 4.1A)IPA A1135 ( 4.4A)NoneNone | 0.94A | 6ce2B-1mc2A:22.7 | 6ce2B-1mc2A:72.13 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1mc2 | ACUTOHAEMONLYSIN (Deinagkistrodonacutus) |
PF00068(Phospholip_A2_1) | 6 | LEU A1002LEU A1005GLY A1023GLY A1030GLY A1033TYR A1052 | IPA A1136 ( 4.7A)IPA A1135 ( 4.2A)IPA A1135 ( 4.1A)IPA A1135 ( 4.4A)NoneNone | 0.88A | 6ce2B-1mc2A:22.7 | 6ce2B-1mc2A:72.13 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1mc2 | ACUTOHAEMONLYSIN (Deinagkistrodonacutus) |
PF00068(Phospholip_A2_1) | 6 | LEU A1005GLY A1023GLY A1030GLY A1033ARG A1034TYR A1052 | IPA A1135 ( 4.2A)IPA A1135 ( 4.1A)IPA A1135 ( 4.4A)NoneNoneNone | 0.54A | 6ce2B-1mc2A:22.7 | 6ce2B-1mc2A:72.13 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1n28 | PHOSPHOLIPASE A2,MEMBRANE ASSOCIATED (Homo sapiens) |
no annotation | 5 | GLY B 22GLY B 29GLY B 31TYR B 51LYS B 62 | None CA B 125 (-4.4A) CA B 125 (-4.2A)NoneNone | 0.83A | 6ce2B-1n28B:20.2 | 6ce2B-1n28B:47.58 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1oa4 | ENDO-BETA-1,4-GLUCANASE (Streptomycessp. 11AG8) |
PF01670(Glyco_hydro_12) | 5 | LEU A 211GLY A 97GLY A 207GLY A 46ASN A 21 | None | 1.08A | 6ce2B-1oa4A:undetectable | 6ce2B-1oa4A:18.78 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1oz6 | PHOSPHOLIPASE A2 (Echis carinatus) |
PF00068(Phospholip_A2_1) | 5 | GLY A 23GLY A 32TYR A 52PRO A 68LYS A 69 | None CA A 134 (-4.3A)NoneNoneNone | 0.86A | 6ce2B-1oz6A:19.6 | 6ce2B-1oz6A:48.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1p43 | ENOLASE 1 (Saccharomycescerevisiae) |
PF00113(Enolase_C)PF03952(Enolase_N) | 5 | LEU A 406LEU A 409GLY A 212GLY A 376ARG A 374 | NoneNoneNoneNone2PG A 441 (-3.9A) | 1.00A | 6ce2B-1p43A:undetectable | 6ce2B-1p43A:13.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pgp | 6-PHOSPHOGLUCONATEDEHYDROGENASE (Ovis aries) |
PF00393(6PGD)PF03446(NAD_binding_2) | 5 | LEU A 352LEU A 341GLY A 177GLY A 179GLY A 126 | None | 1.13A | 6ce2B-1pgpA:undetectable | 6ce2B-1pgpA:16.22 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1po8 | PHOSPHOLIPASE A2 (Bungaruscaeruleus) |
PF00068(Phospholip_A2_1) | 5 | LEU A 5GLY A 30GLY A 32TYR A 52PRO A 63 | NoneSHV A 122 ( 3.7A) NA A 121 (-3.3A)NoneNone | 0.87A | 6ce2B-1po8A:16.7 | 6ce2B-1po8A:36.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pxt | PEROXISOMAL3-KETOACYL-COATHIOLASE (Saccharomycescerevisiae) |
PF00108(Thiolase_N)PF02803(Thiolase_C) | 5 | LEU A 148GLY A 91GLY A 151GLY A 279ASN A 68 | None | 1.13A | 6ce2B-1pxtA:undetectable | 6ce2B-1pxtA:12.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ru4 | PECTATE LYASE (Dickeyachrysanthemi) |
PF13229(Beta_helix) | 5 | LEU A 274LEU A 238GLY A 271GLY A 269ASN A 302 | None | 1.13A | 6ce2B-1ru4A:undetectable | 6ce2B-1ru4A:16.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1sfe | ADAO6-METHYLGUANINE-DNAMETHYLTRANSFERASE (Escherichiacoli) |
PF01035(DNA_binding_1)PF02870(Methyltransf_1N) | 5 | LEU A 27LEU A 51GLY A 34ARG A 33ASN A 138 | None | 1.01A | 6ce2B-1sfeA:undetectable | 6ce2B-1sfeA:19.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1vpe | PHOSPHOGLYCERATEKINASE (Thermotogamaritima) |
PF00162(PGK) | 5 | LEU A 178LEU A 383GLY A 352TYR A 189PRO A 185 | None | 1.12A | 6ce2B-1vpeA:undetectable | 6ce2B-1vpeA:15.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1w85 | PYRUVATEDEHYDROGENASE E1COMPONENT, ALPHASUBUNITPYRUVATEDEHYDROGENASE E1COMPONENT, BETASUBUNIT (Geobacillusstearothermophilus) |
PF00676(E1_dh)PF02779(Transket_pyr)PF02780(Transketolase_C) | 6 | LEU A 99LEU A 138GLY A 153GLY B 68GLY B 73TYR B 108 | None | 1.40A | 6ce2B-1w85A:undetectable | 6ce2B-1w85A:14.72 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1zl7 | HYPOTENSIVEPHOSPHOLIPASE A2 (Bothropsjararacussu) |
PF00068(Phospholip_A2_1) | 5 | GLY A 29GLY A 31TYR A 51ASN A 58PRO A 59 | None CA A1001 (-3.9A)NoneNoneNone | 0.81A | 6ce2B-1zl7A:18.5 | 6ce2B-1zl7A:51.64 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1zl7 | HYPOTENSIVEPHOSPHOLIPASE A2 (Bothropsjararacussu) |
PF00068(Phospholip_A2_1) | 5 | GLY A 29GLY A 31TYR A 51PRO A 59LYS A 60 | None CA A1001 (-3.9A)NoneNoneNone | 1.12A | 6ce2B-1zl7A:18.5 | 6ce2B-1zl7A:51.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2b0o | UPLC1 (Homo sapiens) |
PF01412(ArfGap)PF12796(Ank_2) | 5 | LEU E 564LEU E 561GLY E 457GLY E 498GLY E 437 | None | 1.10A | 6ce2B-2b0oE:undetectable | 6ce2B-2b0oE:17.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bmy | RIPENING-ASSOCIATEDPROTEIN (Musa acuminata) |
PF01419(Jacalin) | 5 | LEU A 92LEU A 89GLY A 39GLY A 59ASN A 106 | None | 1.05A | 6ce2B-2bmyA:undetectable | 6ce2B-2bmyA:21.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2bvg | 6-HYDROXY-D-NICOTINEOXIDASE (Paenarthrobacternicotinovorans) |
PF01565(FAD_binding_4)PF08031(BBE) | 5 | LEU A 435GLY A 187GLY A 189GLY A 193PRO A 456 | None | 1.08A | 6ce2B-2bvgA:undetectable | 6ce2B-2bvgA:12.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c1l | RESTRICTIONENDONUCLEASE (Bacillus firmus) |
PF13091(PLDc_2) | 5 | LEU A 19GLY A 49GLY A 128ASN A 9PRO A 8 | None | 1.05A | 6ce2B-2c1lA:undetectable | 6ce2B-2c1lA:15.77 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2c2n | MALONYL COA-ACYLCARRIER PROTEINTRANSACYLASE (Homo sapiens) |
PF00698(Acyl_transf_1) | 5 | LEU A 249LEU A 280GLY A 135GLY A 128TYR A 270 | None | 1.07A | 6ce2B-2c2nA:undetectable | 6ce2B-2c2nA:14.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fr1 | ERYTHROMYCINSYNTHASE, ERYAI (Saccharopolysporaerythraea) |
PF08659(KR) | 5 | LEU A1549LEU A1553GLY A1594GLY A1596GLY A1609 | None | 1.10A | 6ce2B-2fr1A:undetectable | 6ce2B-2fr1A:11.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2ipc | PREPROTEINTRANSLOCASE SECASUBUNIT (Thermusthermophilus) |
PF01043(SecA_PP_bind)PF07516(SecA_SW)PF07517(SecA_DEAD) | 5 | LEU A 585GLY A 686GLY A 683GLY A 680ARG A 679 | None | 1.14A | 6ce2B-2ipcA:undetectable | 6ce2B-2ipcA:7.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2isn | NYSGXRC-8828Z,PHOSPHATASE (Toxoplasmagondii) |
PF00481(PP2C) | 5 | LEU A 231LEU A 233GLY A 238GLY A 102GLY A 54 | None | 1.09A | 6ce2B-2isnA:undetectable | 6ce2B-2isnA:16.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2iut | DNA TRANSLOCASE FTSK (Pseudomonasaeruginosa) |
PF01580(FtsK_SpoIIIE) | 5 | GLY A 693GLY A 444GLY A 449ARG A 450PRO A 430 | AGS A1723 (-4.0A)NoneNoneNoneNone | 1.09A | 6ce2B-2iutA:undetectable | 6ce2B-2iutA:10.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2o3i | HYPOTHETICAL PROTEIN (Chromobacteriumviolaceum) |
PF06032(DUF917) | 5 | LEU A 255LEU A 251GLY A 233GLY A 16GLY A 110 | None | 0.95A | 6ce2B-2o3iA:undetectable | 6ce2B-2o3iA:14.68 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2osn | PHOSPHOLIPASE A2ISOFORM 3 (Bungaruscaeruleus) |
PF00068(Phospholip_A2_1) | 5 | GLY A 30GLY A 32TYR A 52ASN A 62PRO A 63 | None CL A 121 ( 4.4A)NoneNoneNone | 0.96A | 6ce2B-2osnA:16.6 | 6ce2B-2osnA:33.60 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ph4 | ZHAOERMIATOXIN (Protobothropsmangshanensis) |
PF00068(Phospholip_A2_1) | 6 | LEU A 2LEU A 5GLY A 30GLY A 32PRO A 68LYS A 69 | NonePEG A 401 ( 4.3A)PEG A 401 ( 4.5A)SO4 A 301 (-3.5A)NoneNone | 1.22A | 6ce2B-2ph4A:21.2 | 6ce2B-2ph4A:72.73 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2ph4 | ZHAOERMIATOXIN (Protobothropsmangshanensis) |
PF00068(Phospholip_A2_1) | 6 | LEU A 2LEU A 5GLY A 30TYR A 52PRO A 68LYS A 69 | NonePEG A 401 ( 4.3A)PEG A 401 ( 4.5A)NoneNoneNone | 0.81A | 6ce2B-2ph4A:21.2 | 6ce2B-2ph4A:72.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vfv | XYLITOL OXIDASE (Streptomycescoelicolor) |
PF01565(FAD_binding_4)PF04030(ALO) | 6 | LEU A 60LEU A 20GLY A 45GLY A 43GLY A 84PRO A 23 | NoneNoneSFD A1418 (-3.4A)SFD A1418 (-3.0A)NoneNone | 1.36A | 6ce2B-2vfvA:undetectable | 6ce2B-2vfvA:11.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x4g | NUCLEOSIDE-DIPHOSPHATE-SUGAR EPIMERASE (Pseudomonasaeruginosa) |
PF01370(Epimerase) | 5 | LEU A 52LEU A 41GLY A 22GLY A 25GLY A 222 | None | 1.02A | 6ce2B-2x4gA:undetectable | 6ce2B-2x4gA:12.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xdr | BETAINE ALDEHYDEDEHYDROGENASE (Pseudomonasaeruginosa) |
PF00171(Aldedh) | 5 | LEU A 167GLY A 56GLY A 200GLY A 13TYR A 192 | None | 1.11A | 6ce2B-2xdrA:undetectable | 6ce2B-2xdrA:14.71 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2z8z | LIPASE (Pseudomonas sp.MIS38) |
PF00353(HemolysinCabind) | 5 | LEU A 568GLY A 443GLY A 403GLY A 383TYR A 388 | NoneNone CA A 621 ( 4.7A) CA A 621 (-4.4A)None | 1.12A | 6ce2B-2z8zA:undetectable | 6ce2B-2z8zA:10.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3d7r | ESTERASE (Staphylococcusaureus) |
PF07859(Abhydrolase_3) | 5 | LEU A 99LEU A 98GLY A 150GLY A 85PRO A 93 | NoneDMS A1417 (-3.9A)NoneNoneDMS A1410 (-4.7A) | 1.07A | 6ce2B-3d7rA:undetectable | 6ce2B-3d7rA:15.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3e96 | DIHYDRODIPICOLINATESYNTHASE (Bacillusclausii) |
PF00701(DHDPS) | 5 | LEU A 227LEU A 230GLY A 210GLY A 194LYS A 222 | None | 1.08A | 6ce2B-3e96A:undetectable | 6ce2B-3e96A:14.74 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3egw | RESPIRATORY NITRATEREDUCTASE 1 ALPHACHAIN (Escherichiacoli) |
PF00384(Molybdopterin)PF01568(Molydop_binding)PF14710(Nitr_red_alph_N) | 5 | GLY A1025GLY A 568GLY A 572ARG A 535TYR A 325 | None | 0.95A | 6ce2B-3egwA:undetectable | 6ce2B-3egwA:7.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3eyk | HEMAGGLUTININ HA1CHAIN (Influenza Avirus) |
PF00509(Hemagglutinin) | 5 | LEU A 181GLY A 72GLY A 69ARG A 109LYS A 261 | None | 1.13A | 6ce2B-3eykA:undetectable | 6ce2B-3eykA:16.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gq9 | PRENECK APPENDAGEPROTEIN (Bacillus virusphi29) |
PF11962(Peptidase_G2)PF12708(Pectate_lyase_3) | 6 | LEU A 192LEU A 155GLY A 146ARG A 145ASN A 187PRO A 150 | None | 1.47A | 6ce2B-3gq9A:undetectable | 6ce2B-3gq9A:10.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hn0 | NITRATE TRANSPORTPROTEIN (Parabacteroidesdistasonis) |
no annotation | 5 | LEU A 177LEU A 183GLY A 169GLY A 152LYS A 179 | None | 1.06A | 6ce2B-3hn0A:undetectable | 6ce2B-3hn0A:15.68 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hvn | HEMOLYSIN (Streptococcussuis) |
PF01289(Thiol_cytolysin)PF17440(Thiol_cytolys_C) | 5 | LEU A 351LEU A 158GLY A 271GLY A 354GLY A 325 | None | 1.11A | 6ce2B-3hvnA:undetectable | 6ce2B-3hvnA:11.94 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kg9 | CURK (Lyngbyamajuscula) |
PF14765(PS-DH) | 5 | LEU A 993LEU A 985GLY A1008ARG A1036PRO A1041 | None | 1.07A | 6ce2B-3kg9A:undetectable | 6ce2B-3kg9A:17.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3khj | INOSINE-5-MONOPHOSPHATE DEHYDROGENASE (Cryptosporidiumparvum) |
PF00478(IMPDH) | 5 | LEU A 16GLY A 259GLY A 351ASN A 20PRO A 19 | None | 1.05A | 6ce2B-3khjA:undetectable | 6ce2B-3khjA:18.31 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3kjx | TRANSCRIPTIONALREGULATOR, LACIFAMILY (Ruegeriapomeroyi) |
PF00356(LacI)PF00532(Peripla_BP_1) | 5 | LEU A 277LEU A 249GLY A 273GLY A 182ARG A 184 | None | 1.05A | 6ce2B-3kjxA:undetectable | 6ce2B-3kjxA:13.99 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3pco | PHENYLALANYL-TRNASYNTHETASE, ALPHASUBUNITPHENYLALANYL-TRNASYNTHETASE, BETACHAIN (Escherichiacoli) |
PF01409(tRNA-synt_2d)PF01588(tRNA_bind)PF02912(Phe_tRNA-synt_N)PF03147(FDX-ACB)PF03483(B3_4)PF03484(B5) | 5 | LEU A 227LEU A 223GLY A 296GLY A 271ASN B 472 | NoneNonePHE A 980 (-3.6A)PHE A 980 (-4.0A)None | 0.89A | 6ce2B-3pcoA:undetectable | 6ce2B-3pcoA:16.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3q8x | ZETA-TOXIN (Streptococcuspyogenes) |
PF06414(Zeta_toxin) | 5 | LEU B 203LEU B 226GLY B 39GLY B 40GLY B 43 | NoneNoneNoneNoneSO4 B 602 (-3.3A) | 1.05A | 6ce2B-3q8xB:undetectable | 6ce2B-3q8xB:15.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qk7 | TRANSCRIPTIONALREGULATORS (Yersinia pestis) |
PF00532(Peripla_BP_1) | 5 | LEU A 45LEU A 11GLY A 33GLY A 37ARG A 39 | None | 1.09A | 6ce2B-3qk7A:undetectable | 6ce2B-3qk7A:16.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3qpb | URIDINEPHOSPHORYLASE (Streptococcuspyogenes) |
PF01048(PNP_UDP_1) | 5 | LEU A 202GLY A 73GLY A 74GLY A 121TYR A 126 | None | 1.10A | 6ce2B-3qpbA:undetectable | 6ce2B-3qpbA:18.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3r8e | HYPOTHETICAL SUGARKINASE (Cytophagahutchinsonii) |
PF00480(ROK) | 5 | LEU A 247LEU A 131GLY A 226GLY A 230ASN A 244 | None | 1.04A | 6ce2B-3r8eA:undetectable | 6ce2B-3r8eA:13.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rj8 | CARBOHYDRATE OXIDASE (Microdochiumnivale) |
PF01565(FAD_binding_4)PF08031(BBE) | 5 | LEU A 450GLY A 189GLY A 191GLY A 195PRO A 471 | None | 1.04A | 6ce2B-3rj8A:undetectable | 6ce2B-3rj8A:13.15 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3tl2 | MALATE DEHYDROGENASE (Bacillusanthracis) |
PF00056(Ldh_1_N)PF02866(Ldh_1_C) | 5 | LEU A 268LEU A 270GLY A 261GLY A 264LYS A 294 | None | 1.14A | 6ce2B-3tl2A:undetectable | 6ce2B-3tl2A:17.11 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ugv | ENOLASE (alphaproteobacteriumBAL199) |
PF02746(MR_MLE_N)PF13378(MR_MLE_C) | 5 | LEU A 124LEU A 352GLY A 310TYR A 337PRO A 347 | None | 1.10A | 6ce2B-3ugvA:undetectable | 6ce2B-3ugvA:13.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3vov | GLUCOKINASE (Thermusthermophilus) |
PF00480(ROK) | 5 | LEU A 243GLY A 138GLY A 137GLY A 135ASN A 250 | None | 1.14A | 6ce2B-3vovA:undetectable | 6ce2B-3vovA:14.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4bkw | ZINC FINGER FYVEDOMAIN-CONTAININGPROTEIN 9 (Homo sapiens) |
PF11979(DUF3480) | 5 | LEU A1046LEU A1043GLY A1056TYR A1053PRO A1049 | None | 1.09A | 6ce2B-4bkwA:undetectable | 6ce2B-4bkwA:10.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4chb | KELCH-LIKE PROTEIN 2 (Homo sapiens) |
PF01344(Kelch_1) | 5 | LEU A 449GLY A 394GLY A 441GLY A 490ARG A 486 | None | 1.03A | 6ce2B-4chbA:undetectable | 6ce2B-4chbA:16.23 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4fs7 | UNCHARACTERIZEDPROTEIN (Bacteroidesovatus) |
PF13306(LRR_5) | 6 | LEU A 148GLY A 152GLY A 129GLY A 106ASN A 120PRO A 122 | None | 1.23A | 6ce2B-4fs7A:undetectable | 6ce2B-4fs7A:17.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4h79 | CRISPR-ASSOCIATEDPROTEIN, CSE2 FAMILY (Thermobifidafusca) |
PF09485(CRISPR_Cse2) | 5 | LEU A 156GLY A 113GLY A 111GLY A 109TYR A 165 | NoneNoneNoneEDO A 301 (-4.7A)None | 1.07A | 6ce2B-4h79A:undetectable | 6ce2B-4h79A:18.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i3g | BETA-GLUCOSIDASE (Streptomycesvenezuelae) |
PF00933(Glyco_hydro_3)PF01915(Glyco_hydro_3_C)PF14310(Fn3-like) | 5 | LEU A 453LEU A 476GLY A 544GLY A 445PRO A 479 | None | 1.12A | 6ce2B-4i3gA:undetectable | 6ce2B-4i3gA:9.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4kg7 | PEPTIDASE S8 ANDS53, SUBTILISIN,KEXIN, SEDOLISIN (Mycolicibacteriumsmegmatis) |
PF00082(Peptidase_S8) | 5 | LEU A 202GLY A 97GLY A 127GLY A 132TYR A 342 | None | 1.04A | 6ce2B-4kg7A:undetectable | 6ce2B-4kg7A:12.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4l7z | HPCH/HPAI ALDOLASE (Chloroflexusaurantiacus) |
PF03328(HpcH_HpaI) | 5 | LEU A 156LEU A 155GLY A 177GLY A 270PRO A 182 | None | 1.11A | 6ce2B-4l7zA:undetectable | 6ce2B-4l7zA:14.29 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4muo | UNCHARACTERIZEDPROTEIN YBIB (Escherichiacoli) |
PF02885(Glycos_trans_3N) | 5 | LEU A 108LEU A 105GLY A 312GLY A 304PRO A 111 | None | 1.11A | 6ce2B-4muoA:undetectable | 6ce2B-4muoA:14.11 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4wtb | BASIC PHOSPHOLIPASEA2 HOMOLOGBOTHROPSTOXIN-1 (Bothropsjararacussu) |
PF00068(Phospholip_A2_1) | 8 | LEU A 2LEU A 5GLY A 22GLY A 29GLY A 32ARG A 33LYS A 48TYR A 51 | NoneNoneNoneNoneNoneNone ZN A 201 ( 4.2A)None | 0.98A | 6ce2B-4wtbA:22.9 | 6ce2B-4wtbA:85.12 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4wtb | BASIC PHOSPHOLIPASEA2 HOMOLOGBOTHROPSTOXIN-1 (Bothropsjararacussu) |
PF00068(Phospholip_A2_1) | 8 | LEU A 5GLY A 22GLY A 29GLY A 32ARG A 33LYS A 48TYR A 51PRO A 59 | NoneNoneNoneNoneNone ZN A 201 ( 4.2A)NoneNone | 0.74A | 6ce2B-4wtbA:22.9 | 6ce2B-4wtbA:85.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4yis | MEGANUCLEASE I-CPAMI (Cryphonectriaparasitica) |
PF00961(LAGLIDADG_1) | 5 | LEU A 45LEU A 52GLY A 176LYS A 48LYS A 47 | NoneNone CA A 302 (-3.9A)NoneNone | 1.04A | 6ce2B-4yisA:undetectable | 6ce2B-4yisA:19.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5bnn | CAPSID PROTEIN VP2 (Enterovirus D) |
PF00073(Rhv) | 5 | GLY B 90GLY B 93TYR B 102ASN B 205LYS B 81 | None | 1.09A | 6ce2B-5bnnB:undetectable | 6ce2B-5bnnB:17.55 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f7c | ALPHA-GLUCOSIDASE (Bacteroidesthetaiotaomicron) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2) | 5 | LEU A 222LEU A 262GLY A 207ASN A 481LYS A 225 | None | 1.02A | 6ce2B-5f7cA:undetectable | 6ce2B-5f7cA:9.34 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5h3k | SLR0280 PROTEIN (Synechocystissp. PCC 6803) |
no annotation | 5 | LEU A 93GLY A 84GLY A 81GLY A 79ARG A 117 | None | 1.12A | 6ce2B-5h3kA:undetectable | 6ce2B-5h3kA:9.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5inr | DIPEPTIDASE (Lactobacillusfarciminis) |
PF03577(Peptidase_C69) | 5 | LEU A 214LEU A 211GLY A 172GLY A 234ARG A 230 | NoneNoneNoneEDO A 509 (-4.2A)None | 0.84A | 6ce2B-5inrA:undetectable | 6ce2B-5inrA:13.02 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ktk | POLYKETIDE SYNTHASEPKSJ (Bacillussubtilis) |
PF08659(KR) | 5 | LEU A 221LEU A 247GLY A 231GLY A 226GLY A 251 | NoneNoneNoneNDP A 601 ( 4.9A)NDP A 601 (-3.6A) | 1.11A | 6ce2B-5ktkA:undetectable | 6ce2B-5ktkA:12.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nck | N-ACETYLMANNOSAMINEKINASE (Fusobacteriumnucleatum) |
PF00480(ROK) | 5 | LEU A 146GLY A 279GLY A 114GLY A 119ASN A 126 | None | 1.06A | 6ce2B-5nckA:undetectable | 6ce2B-5nckA:15.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5owc | - (-) |
no annotation | 5 | LEU A 5GLY A 28GLY A 30TYR A 50PRO A 60 | AYZ A 202 (-4.6A)AYZ A 202 ( 3.5A)AYZ A 202 ( 3.6A)AYZ A 202 ( 4.9A)None | 0.76A | 6ce2B-5owcA:18.9 | 6ce2B-5owcA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5owc | - (-) |
no annotation | 5 | LEU A 5GLY A 28TYR A 50PRO A 60LYS A 61 | AYZ A 202 (-4.6A)AYZ A 202 ( 3.5A)AYZ A 202 ( 4.9A)NoneNone | 0.88A | 6ce2B-5owcA:18.9 | 6ce2B-5owcA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tnv | AP ENDONUCLEASE,FAMILY PROTEIN 2 (Mycolicibacteriumsmegmatis) |
PF01261(AP_endonuc_2) | 5 | LEU A 151LEU A 148GLY A 96GLY A 121TYR A 179 | None | 1.05A | 6ce2B-5tnvA:undetectable | 6ce2B-5tnvA:16.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ul4 | OXSB PROTEIN (Bacillusmegaterium) |
PF02310(B12-binding) | 5 | LEU A 147LEU A 152GLY A 241ASN A 58LYS A 149 | NoneNoneB12 A 802 (-3.5A)NoneNone | 0.98A | 6ce2B-5ul4A:undetectable | 6ce2B-5ul4A:10.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uze | INOSINE-5'-MONOPHOSPHATEDEHYDROGENASE,INOSINE-5'-MONOPHOSPHATEDEHYDROGENASE (Clostridiumperfringens) |
PF00478(IMPDH) | 5 | LEU A 15GLY A 343GLY A 433ASN A 19PRO A 18 | None | 1.12A | 6ce2B-5uzeA:undetectable | 6ce2B-5uzeA:15.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vlh | PROPROTEINCONVERTASESUBTILISIN/KEXINTYPE 9 (Homo sapiens) |
PF00082(Peptidase_S8)PF05922(Inhibitor_I9) | 5 | LEU A 304LEU A 118GLY A 267GLY A 263ASN A 298 | None | 1.13A | 6ce2B-5vlhA:undetectable | 6ce2B-5vlhA:14.40 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wvo | DNA(CYTOSINE-5)-METHYLTRANSFERASE 1 (Homo sapiens) |
no annotation | 5 | GLY C 471GLY C 468LYS C 510TYR C 507PRO C 537 | None | 1.10A | 6ce2B-5wvoC:undetectable | 6ce2B-5wvoC:15.20 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wzm | GROUP IIE SECRETORYPHOSPHOLIPASE A2 (Homo sapiens) |
no annotation | 5 | GLY A 28GLY A 30TYR A 50PRO A 60LYS A 61 | CA A 210 (-4.3A) CA A 210 (-4.2A)None CL A 201 (-3.7A) CL A 201 (-4.0A) | 0.98A | 6ce2B-5wzmA:18.5 | 6ce2B-5wzmA:29.75 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ypz | COFB (Escherichiacoli) |
no annotation | 5 | GLY A 106GLY A 104ARG A 110ASN A 82PRO A 79 | None | 1.14A | 6ce2B-5ypzA:undetectable | 6ce2B-5ypzA:17.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5z5c | CYSTEINE SYNTHASE (Fusobacteriumnucleatum) |
no annotation | 5 | LEU A 216GLY A 186GLY A 184GLY A 229ASN A 212 | NonePLP A 401 (-3.5A)PLP A 401 (-3.6A)PLP A 401 (-3.6A)None | 1.06A | 6ce2B-5z5cA:undetectable | 6ce2B-5z5cA:20.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cgm | RIBONUCLEOSIDE-DIPHOSPHATE REDUCTASE (Bacillussubtilis) |
no annotation | 5 | LEU A 203LEU A 251GLY A 225GLY A 222GLY A 210 | None | 1.07A | 6ce2B-6cgmA:undetectable | 6ce2B-6cgmA:21.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gy5 | - (-) |
no annotation | 5 | LEU A 320GLY A 548GLY A 595GLY A 359ARG A 355 | NoneEDO A 710 (-3.3A)EDO A 710 (-3.2A)NoneNone | 1.04A | 6ce2B-6gy5A:undetectable | 6ce2B-6gy5A:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6gy5 | - (-) |
no annotation | 5 | LEU A 556GLY A 501GLY A 548GLY A 595ARG A 591 | NoneNoneEDO A 710 (-3.3A)EDO A 710 (-3.2A)None | 1.12A | 6ce2B-6gy5A:undetectable | 6ce2B-6gy5A:undetectable |