SIMILAR PATTERNS OF AMINO ACIDS FOR 6CE2_B_SVRB202_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bgc GRANULOCYTE
COLONY-STIMULATING
FACTOR


(Bos taurus)
PF16647
(GCSF)
5 LEU A 172
LEU A 169
GLY A  74
GLY A 126
PRO A  11
None
1.05A 6ce2B-1bgcA:
undetectable
6ce2B-1bgcA:
20.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bpq PHOSPHOLIPASE A2

(Bos taurus)
PF00068
(Phospholip_A2_1)
5 LEU A   2
GLY A  30
GLY A  32
TYR A  52
PRO A  68
None
CA  A 124 (-4.2A)
CA  A 124 (-4.2A)
None
None
0.93A 6ce2B-1bpqA:
17.6
6ce2B-1bpqA:
37.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bun BETA2-BUNGAROTOXIN

(Bungarus
multicinctus)
PF00068
(Phospholip_A2_1)
6 GLY A  30
GLY A  32
TYR A  52
ASN A  62
PRO A  63
LYS A  64
NA  A 121 (-4.4A)
NA  A 121 (-3.8A)
None
None
None
None
1.00A 6ce2B-1bunA:
16.4
6ce2B-1bunA:
37.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bun BETA2-BUNGAROTOXIN

(Bungarus
multicinctus)
PF00068
(Phospholip_A2_1)
6 LEU A   2
GLY A  32
TYR A  52
ASN A  62
PRO A  63
LYS A  64
None
NA  A 121 (-3.8A)
None
None
None
None
0.93A 6ce2B-1bunA:
16.4
6ce2B-1bunA:
37.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cvr GINGIPAIN R

(Porphyromonas
gingivalis)
PF01364
(Peptidase_C25)
PF03785
(Peptidase_C25_C)
5 LEU A 345
GLY A  35
ARG A  11
TYR A  72
PRO A 342
None
1.13A 6ce2B-1cvrA:
undetectable
6ce2B-1cvrA:
13.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dpy PHOSPHOLIPASE A2

(Bungarus
caeruleus)
PF00068
(Phospholip_A2_1)
5 GLY A  30
GLY A  32
TYR A  52
ASN A  62
PRO A  63
NA  A 150 (-4.5A)
NA  A 150 (-4.5A)
None
None
None
1.03A 6ce2B-1dpyA:
16.8
6ce2B-1dpyA:
36.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1esc ESTERASE

(Streptomyces
scabiei)
PF13472
(Lipase_GDSL_2)
5 LEU A 220
LEU A 217
GLY A 263
ARG A 260
PRO A 191
None
1.06A 6ce2B-1escA:
undetectable
6ce2B-1escA:
18.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1g0z PHOSPHOLIPASE A2

(Bungarus
caeruleus)
PF00068
(Phospholip_A2_1)
5 GLY A  30
GLY A  32
TYR A  52
ASN A  62
PRO A  63
None
0.95A 6ce2B-1g0zA:
16.5
6ce2B-1g0zA:
34.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gju MALTODEXTRIN
GLYCOSYLTRANSFERASE


(Thermotoga
maritima)
PF00128
(Alpha-amylase)
PF09083
(DUF1923)
5 LEU A 433
LEU A 461
GLY A 381
ARG A 197
PRO A 459
None
1.14A 6ce2B-1gjuA:
undetectable
6ce2B-1gjuA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lkf LEUKOCIDIN F SUBUNIT

(Staphylococcus
aureus)
PF07968
(Leukocidin)
5 LEU A  36
GLY A   2
TYR A 245
ASN A 222
PRO A 223
None
1.06A 6ce2B-1lkfA:
undetectable
6ce2B-1lkfA:
14.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mc2 ACUTOHAEMONLYSIN

(Deinagkistrodon
acutus)
PF00068
(Phospholip_A2_1)
6 LEU A1002
GLY A1023
GLY A1030
GLY A1033
ARG A1034
LYS A1049
IPA  A1136 ( 4.7A)
IPA  A1135 ( 4.1A)
IPA  A1135 ( 4.4A)
None
None
None
1.27A 6ce2B-1mc2A:
22.7
6ce2B-1mc2A:
72.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mc2 ACUTOHAEMONLYSIN

(Deinagkistrodon
acutus)
PF00068
(Phospholip_A2_1)
5 LEU A1002
GLY A1023
GLY A1030
GLY A1033
LYS A1049
IPA  A1136 ( 4.7A)
IPA  A1135 ( 4.1A)
IPA  A1135 ( 4.4A)
None
None
0.94A 6ce2B-1mc2A:
22.7
6ce2B-1mc2A:
72.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mc2 ACUTOHAEMONLYSIN

(Deinagkistrodon
acutus)
PF00068
(Phospholip_A2_1)
6 LEU A1002
LEU A1005
GLY A1023
GLY A1030
GLY A1033
TYR A1052
IPA  A1136 ( 4.7A)
IPA  A1135 ( 4.2A)
IPA  A1135 ( 4.1A)
IPA  A1135 ( 4.4A)
None
None
0.88A 6ce2B-1mc2A:
22.7
6ce2B-1mc2A:
72.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mc2 ACUTOHAEMONLYSIN

(Deinagkistrodon
acutus)
PF00068
(Phospholip_A2_1)
6 LEU A1005
GLY A1023
GLY A1030
GLY A1033
ARG A1034
TYR A1052
IPA  A1135 ( 4.2A)
IPA  A1135 ( 4.1A)
IPA  A1135 ( 4.4A)
None
None
None
0.54A 6ce2B-1mc2A:
22.7
6ce2B-1mc2A:
72.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n28 PHOSPHOLIPASE A2,
MEMBRANE ASSOCIATED


(Homo sapiens)
no annotation 5 GLY B  22
GLY B  29
GLY B  31
TYR B  51
LYS B  62
None
CA  B 125 (-4.4A)
CA  B 125 (-4.2A)
None
None
0.83A 6ce2B-1n28B:
20.2
6ce2B-1n28B:
47.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oa4 ENDO-BETA-1,4-GLUCAN
ASE


(Streptomyces
sp. 11AG8)
PF01670
(Glyco_hydro_12)
5 LEU A 211
GLY A  97
GLY A 207
GLY A  46
ASN A  21
None
1.08A 6ce2B-1oa4A:
undetectable
6ce2B-1oa4A:
18.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1oz6 PHOSPHOLIPASE A2

(Echis carinatus)
PF00068
(Phospholip_A2_1)
5 GLY A  23
GLY A  32
TYR A  52
PRO A  68
LYS A  69
None
CA  A 134 (-4.3A)
None
None
None
0.86A 6ce2B-1oz6A:
19.6
6ce2B-1oz6A:
48.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p43 ENOLASE 1

(Saccharomyces
cerevisiae)
PF00113
(Enolase_C)
PF03952
(Enolase_N)
5 LEU A 406
LEU A 409
GLY A 212
GLY A 376
ARG A 374
None
None
None
None
2PG  A 441 (-3.9A)
1.00A 6ce2B-1p43A:
undetectable
6ce2B-1p43A:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgp 6-PHOSPHOGLUCONATE
DEHYDROGENASE


(Ovis aries)
PF00393
(6PGD)
PF03446
(NAD_binding_2)
5 LEU A 352
LEU A 341
GLY A 177
GLY A 179
GLY A 126
None
1.13A 6ce2B-1pgpA:
undetectable
6ce2B-1pgpA:
16.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1po8 PHOSPHOLIPASE A2

(Bungarus
caeruleus)
PF00068
(Phospholip_A2_1)
5 LEU A   5
GLY A  30
GLY A  32
TYR A  52
PRO A  63
None
SHV  A 122 ( 3.7A)
NA  A 121 (-3.3A)
None
None
0.87A 6ce2B-1po8A:
16.7
6ce2B-1po8A:
36.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE


(Saccharomyces
cerevisiae)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
5 LEU A 148
GLY A  91
GLY A 151
GLY A 279
ASN A  68
None
1.13A 6ce2B-1pxtA:
undetectable
6ce2B-1pxtA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ru4 PECTATE LYASE

(Dickeya
chrysanthemi)
PF13229
(Beta_helix)
5 LEU A 274
LEU A 238
GLY A 271
GLY A 269
ASN A 302
None
1.13A 6ce2B-1ru4A:
undetectable
6ce2B-1ru4A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfe ADA
O6-METHYLGUANINE-DNA
METHYLTRANSFERASE


(Escherichia
coli)
PF01035
(DNA_binding_1)
PF02870
(Methyltransf_1N)
5 LEU A  27
LEU A  51
GLY A  34
ARG A  33
ASN A 138
None
1.01A 6ce2B-1sfeA:
undetectable
6ce2B-1sfeA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpe PHOSPHOGLYCERATE
KINASE


(Thermotoga
maritima)
PF00162
(PGK)
5 LEU A 178
LEU A 383
GLY A 352
TYR A 189
PRO A 185
None
1.12A 6ce2B-1vpeA:
undetectable
6ce2B-1vpeA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w85 PYRUVATE
DEHYDROGENASE E1
COMPONENT, ALPHA
SUBUNIT
PYRUVATE
DEHYDROGENASE E1
COMPONENT, BETA
SUBUNIT


(Geobacillus
stearothermophilus)
PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
6 LEU A  99
LEU A 138
GLY A 153
GLY B  68
GLY B  73
TYR B 108
None
1.40A 6ce2B-1w85A:
undetectable
6ce2B-1w85A:
14.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zl7 HYPOTENSIVE
PHOSPHOLIPASE A2


(Bothrops
jararacussu)
PF00068
(Phospholip_A2_1)
5 GLY A  29
GLY A  31
TYR A  51
ASN A  58
PRO A  59
None
CA  A1001 (-3.9A)
None
None
None
0.81A 6ce2B-1zl7A:
18.5
6ce2B-1zl7A:
51.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zl7 HYPOTENSIVE
PHOSPHOLIPASE A2


(Bothrops
jararacussu)
PF00068
(Phospholip_A2_1)
5 GLY A  29
GLY A  31
TYR A  51
PRO A  59
LYS A  60
None
CA  A1001 (-3.9A)
None
None
None
1.12A 6ce2B-1zl7A:
18.5
6ce2B-1zl7A:
51.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0o UPLC1

(Homo sapiens)
PF01412
(ArfGap)
PF12796
(Ank_2)
5 LEU E 564
LEU E 561
GLY E 457
GLY E 498
GLY E 437
None
1.10A 6ce2B-2b0oE:
undetectable
6ce2B-2b0oE:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmy RIPENING-ASSOCIATED
PROTEIN


(Musa acuminata)
PF01419
(Jacalin)
5 LEU A  92
LEU A  89
GLY A  39
GLY A  59
ASN A 106
None
1.05A 6ce2B-2bmyA:
undetectable
6ce2B-2bmyA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvg 6-HYDROXY-D-NICOTINE
OXIDASE


(Paenarthrobacter
nicotinovorans)
PF01565
(FAD_binding_4)
PF08031
(BBE)
5 LEU A 435
GLY A 187
GLY A 189
GLY A 193
PRO A 456
None
1.08A 6ce2B-2bvgA:
undetectable
6ce2B-2bvgA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1l RESTRICTION
ENDONUCLEASE


(Bacillus firmus)
PF13091
(PLDc_2)
5 LEU A  19
GLY A  49
GLY A 128
ASN A   9
PRO A   8
None
1.05A 6ce2B-2c1lA:
undetectable
6ce2B-2c1lA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2n MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE


(Homo sapiens)
PF00698
(Acyl_transf_1)
5 LEU A 249
LEU A 280
GLY A 135
GLY A 128
TYR A 270
None
1.07A 6ce2B-2c2nA:
undetectable
6ce2B-2c2nA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI


(Saccharopolyspora
erythraea)
PF08659
(KR)
5 LEU A1549
LEU A1553
GLY A1594
GLY A1596
GLY A1609
None
1.10A 6ce2B-2fr1A:
undetectable
6ce2B-2fr1A:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT


(Thermus
thermophilus)
PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD)
5 LEU A 585
GLY A 686
GLY A 683
GLY A 680
ARG A 679
None
1.14A 6ce2B-2ipcA:
undetectable
6ce2B-2ipcA:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isn NYSGXRC-8828Z,
PHOSPHATASE


(Toxoplasma
gondii)
PF00481
(PP2C)
5 LEU A 231
LEU A 233
GLY A 238
GLY A 102
GLY A  54
None
1.09A 6ce2B-2isnA:
undetectable
6ce2B-2isnA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iut DNA TRANSLOCASE FTSK

(Pseudomonas
aeruginosa)
PF01580
(FtsK_SpoIIIE)
5 GLY A 693
GLY A 444
GLY A 449
ARG A 450
PRO A 430
AGS  A1723 (-4.0A)
None
None
None
None
1.09A 6ce2B-2iutA:
undetectable
6ce2B-2iutA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3i HYPOTHETICAL PROTEIN

(Chromobacterium
violaceum)
PF06032
(DUF917)
5 LEU A 255
LEU A 251
GLY A 233
GLY A  16
GLY A 110
None
0.95A 6ce2B-2o3iA:
undetectable
6ce2B-2o3iA:
14.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2osn PHOSPHOLIPASE A2
ISOFORM 3


(Bungarus
caeruleus)
PF00068
(Phospholip_A2_1)
5 GLY A  30
GLY A  32
TYR A  52
ASN A  62
PRO A  63
None
CL  A 121 ( 4.4A)
None
None
None
0.96A 6ce2B-2osnA:
16.6
6ce2B-2osnA:
33.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ph4 ZHAOERMIATOXIN

(Protobothrops
mangshanensis)
PF00068
(Phospholip_A2_1)
6 LEU A   2
LEU A   5
GLY A  30
GLY A  32
PRO A  68
LYS A  69
None
PEG  A 401 ( 4.3A)
PEG  A 401 ( 4.5A)
SO4  A 301 (-3.5A)
None
None
1.22A 6ce2B-2ph4A:
21.2
6ce2B-2ph4A:
72.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ph4 ZHAOERMIATOXIN

(Protobothrops
mangshanensis)
PF00068
(Phospholip_A2_1)
6 LEU A   2
LEU A   5
GLY A  30
TYR A  52
PRO A  68
LYS A  69
None
PEG  A 401 ( 4.3A)
PEG  A 401 ( 4.5A)
None
None
None
0.81A 6ce2B-2ph4A:
21.2
6ce2B-2ph4A:
72.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vfv XYLITOL OXIDASE

(Streptomyces
coelicolor)
PF01565
(FAD_binding_4)
PF04030
(ALO)
6 LEU A  60
LEU A  20
GLY A  45
GLY A  43
GLY A  84
PRO A  23
None
None
SFD  A1418 (-3.4A)
SFD  A1418 (-3.0A)
None
None
1.36A 6ce2B-2vfvA:
undetectable
6ce2B-2vfvA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4g NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE


(Pseudomonas
aeruginosa)
PF01370
(Epimerase)
5 LEU A  52
LEU A  41
GLY A  22
GLY A  25
GLY A 222
None
1.02A 6ce2B-2x4gA:
undetectable
6ce2B-2x4gA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdr BETAINE ALDEHYDE
DEHYDROGENASE


(Pseudomonas
aeruginosa)
PF00171
(Aldedh)
5 LEU A 167
GLY A  56
GLY A 200
GLY A  13
TYR A 192
None
1.11A 6ce2B-2xdrA:
undetectable
6ce2B-2xdrA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8z LIPASE

(Pseudomonas sp.
MIS38)
PF00353
(HemolysinCabind)
5 LEU A 568
GLY A 443
GLY A 403
GLY A 383
TYR A 388
None
None
CA  A 621 ( 4.7A)
CA  A 621 (-4.4A)
None
1.12A 6ce2B-2z8zA:
undetectable
6ce2B-2z8zA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7r ESTERASE

(Staphylococcus
aureus)
PF07859
(Abhydrolase_3)
5 LEU A  99
LEU A  98
GLY A 150
GLY A  85
PRO A  93
None
DMS  A1417 (-3.9A)
None
None
DMS  A1410 (-4.7A)
1.07A 6ce2B-3d7rA:
undetectable
6ce2B-3d7rA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e96 DIHYDRODIPICOLINATE
SYNTHASE


(Bacillus
clausii)
PF00701
(DHDPS)
5 LEU A 227
LEU A 230
GLY A 210
GLY A 194
LYS A 222
None
1.08A 6ce2B-3e96A:
undetectable
6ce2B-3e96A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN


(Escherichia
coli)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N)
5 GLY A1025
GLY A 568
GLY A 572
ARG A 535
TYR A 325
None
0.95A 6ce2B-3egwA:
undetectable
6ce2B-3egwA:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eyk HEMAGGLUTININ HA1
CHAIN


(Influenza A
virus)
PF00509
(Hemagglutinin)
5 LEU A 181
GLY A  72
GLY A  69
ARG A 109
LYS A 261
None
1.13A 6ce2B-3eykA:
undetectable
6ce2B-3eykA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gq9 PRENECK APPENDAGE
PROTEIN


(Bacillus virus
phi29)
PF11962
(Peptidase_G2)
PF12708
(Pectate_lyase_3)
6 LEU A 192
LEU A 155
GLY A 146
ARG A 145
ASN A 187
PRO A 150
None
1.47A 6ce2B-3gq9A:
undetectable
6ce2B-3gq9A:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn0 NITRATE TRANSPORT
PROTEIN


(Parabacteroides
distasonis)
no annotation 5 LEU A 177
LEU A 183
GLY A 169
GLY A 152
LYS A 179
None
1.06A 6ce2B-3hn0A:
undetectable
6ce2B-3hn0A:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvn HEMOLYSIN

(Streptococcus
suis)
PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C)
5 LEU A 351
LEU A 158
GLY A 271
GLY A 354
GLY A 325
None
1.11A 6ce2B-3hvnA:
undetectable
6ce2B-3hvnA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg9 CURK

(Lyngbya
majuscula)
PF14765
(PS-DH)
5 LEU A 993
LEU A 985
GLY A1008
ARG A1036
PRO A1041
None
1.07A 6ce2B-3kg9A:
undetectable
6ce2B-3kg9A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khj INOSINE-5-MONOPHOSPH
ATE DEHYDROGENASE


(Cryptosporidium
parvum)
PF00478
(IMPDH)
5 LEU A  16
GLY A 259
GLY A 351
ASN A  20
PRO A  19
None
1.05A 6ce2B-3khjA:
undetectable
6ce2B-3khjA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kjx TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY


(Ruegeria
pomeroyi)
PF00356
(LacI)
PF00532
(Peripla_BP_1)
5 LEU A 277
LEU A 249
GLY A 273
GLY A 182
ARG A 184
None
1.05A 6ce2B-3kjxA:
undetectable
6ce2B-3kjxA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pco PHENYLALANYL-TRNA
SYNTHETASE, ALPHA
SUBUNIT
PHENYLALANYL-TRNA
SYNTHETASE, BETA
CHAIN


(Escherichia
coli)
PF01409
(tRNA-synt_2d)
PF01588
(tRNA_bind)
PF02912
(Phe_tRNA-synt_N)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5)
5 LEU A 227
LEU A 223
GLY A 296
GLY A 271
ASN B 472
None
None
PHE  A 980 (-3.6A)
PHE  A 980 (-4.0A)
None
0.89A 6ce2B-3pcoA:
undetectable
6ce2B-3pcoA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q8x ZETA-TOXIN

(Streptococcus
pyogenes)
PF06414
(Zeta_toxin)
5 LEU B 203
LEU B 226
GLY B  39
GLY B  40
GLY B  43
None
None
None
None
SO4  B 602 (-3.3A)
1.05A 6ce2B-3q8xB:
undetectable
6ce2B-3q8xB:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qk7 TRANSCRIPTIONAL
REGULATORS


(Yersinia pestis)
PF00532
(Peripla_BP_1)
5 LEU A  45
LEU A  11
GLY A  33
GLY A  37
ARG A  39
None
1.09A 6ce2B-3qk7A:
undetectable
6ce2B-3qk7A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpb URIDINE
PHOSPHORYLASE


(Streptococcus
pyogenes)
PF01048
(PNP_UDP_1)
5 LEU A 202
GLY A  73
GLY A  74
GLY A 121
TYR A 126
None
1.10A 6ce2B-3qpbA:
undetectable
6ce2B-3qpbA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r8e HYPOTHETICAL SUGAR
KINASE


(Cytophaga
hutchinsonii)
PF00480
(ROK)
5 LEU A 247
LEU A 131
GLY A 226
GLY A 230
ASN A 244
None
1.04A 6ce2B-3r8eA:
undetectable
6ce2B-3r8eA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rj8 CARBOHYDRATE OXIDASE

(Microdochium
nivale)
PF01565
(FAD_binding_4)
PF08031
(BBE)
5 LEU A 450
GLY A 189
GLY A 191
GLY A 195
PRO A 471
None
1.04A 6ce2B-3rj8A:
undetectable
6ce2B-3rj8A:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tl2 MALATE DEHYDROGENASE

(Bacillus
anthracis)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 LEU A 268
LEU A 270
GLY A 261
GLY A 264
LYS A 294
None
1.14A 6ce2B-3tl2A:
undetectable
6ce2B-3tl2A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugv ENOLASE

(alpha
proteobacterium
BAL199)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 LEU A 124
LEU A 352
GLY A 310
TYR A 337
PRO A 347
None
1.10A 6ce2B-3ugvA:
undetectable
6ce2B-3ugvA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vov GLUCOKINASE

(Thermus
thermophilus)
PF00480
(ROK)
5 LEU A 243
GLY A 138
GLY A 137
GLY A 135
ASN A 250
None
1.14A 6ce2B-3vovA:
undetectable
6ce2B-3vovA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9


(Homo sapiens)
PF11979
(DUF3480)
5 LEU A1046
LEU A1043
GLY A1056
TYR A1053
PRO A1049
None
1.09A 6ce2B-4bkwA:
undetectable
6ce2B-4bkwA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4chb KELCH-LIKE PROTEIN 2

(Homo sapiens)
PF01344
(Kelch_1)
5 LEU A 449
GLY A 394
GLY A 441
GLY A 490
ARG A 486
None
1.03A 6ce2B-4chbA:
undetectable
6ce2B-4chbA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fs7 UNCHARACTERIZED
PROTEIN


(Bacteroides
ovatus)
PF13306
(LRR_5)
6 LEU A 148
GLY A 152
GLY A 129
GLY A 106
ASN A 120
PRO A 122
None
1.23A 6ce2B-4fs7A:
undetectable
6ce2B-4fs7A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h79 CRISPR-ASSOCIATED
PROTEIN, CSE2 FAMILY


(Thermobifida
fusca)
PF09485
(CRISPR_Cse2)
5 LEU A 156
GLY A 113
GLY A 111
GLY A 109
TYR A 165
None
None
None
EDO  A 301 (-4.7A)
None
1.07A 6ce2B-4h79A:
undetectable
6ce2B-4h79A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3g BETA-GLUCOSIDASE

(Streptomyces
venezuelae)
PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like)
5 LEU A 453
LEU A 476
GLY A 544
GLY A 445
PRO A 479
None
1.12A 6ce2B-4i3gA:
undetectable
6ce2B-4i3gA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN


(Mycolicibacterium
smegmatis)
PF00082
(Peptidase_S8)
5 LEU A 202
GLY A  97
GLY A 127
GLY A 132
TYR A 342
None
1.04A 6ce2B-4kg7A:
undetectable
6ce2B-4kg7A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7z HPCH/HPAI ALDOLASE

(Chloroflexus
aurantiacus)
PF03328
(HpcH_HpaI)
5 LEU A 156
LEU A 155
GLY A 177
GLY A 270
PRO A 182
None
1.11A 6ce2B-4l7zA:
undetectable
6ce2B-4l7zA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4muo UNCHARACTERIZED
PROTEIN YBIB


(Escherichia
coli)
PF02885
(Glycos_trans_3N)
5 LEU A 108
LEU A 105
GLY A 312
GLY A 304
PRO A 111
None
1.11A 6ce2B-4muoA:
undetectable
6ce2B-4muoA:
14.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wtb BASIC PHOSPHOLIPASE
A2 HOMOLOG
BOTHROPSTOXIN-1


(Bothrops
jararacussu)
PF00068
(Phospholip_A2_1)
8 LEU A   2
LEU A   5
GLY A  22
GLY A  29
GLY A  32
ARG A  33
LYS A  48
TYR A  51
None
None
None
None
None
None
ZN  A 201 ( 4.2A)
None
0.98A 6ce2B-4wtbA:
22.9
6ce2B-4wtbA:
85.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wtb BASIC PHOSPHOLIPASE
A2 HOMOLOG
BOTHROPSTOXIN-1


(Bothrops
jararacussu)
PF00068
(Phospholip_A2_1)
8 LEU A   5
GLY A  22
GLY A  29
GLY A  32
ARG A  33
LYS A  48
TYR A  51
PRO A  59
None
None
None
None
None
ZN  A 201 ( 4.2A)
None
None
0.74A 6ce2B-4wtbA:
22.9
6ce2B-4wtbA:
85.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yis MEGANUCLEASE I-CPAMI

(Cryphonectria
parasitica)
PF00961
(LAGLIDADG_1)
5 LEU A  45
LEU A  52
GLY A 176
LYS A  48
LYS A  47
None
None
CA  A 302 (-3.9A)
None
None
1.04A 6ce2B-4yisA:
undetectable
6ce2B-4yisA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnn CAPSID PROTEIN VP2

(Enterovirus D)
PF00073
(Rhv)
5 GLY B  90
GLY B  93
TYR B 102
ASN B 205
LYS B  81
None
1.09A 6ce2B-5bnnB:
undetectable
6ce2B-5bnnB:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7c ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron)
PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
5 LEU A 222
LEU A 262
GLY A 207
ASN A 481
LYS A 225
None
1.02A 6ce2B-5f7cA:
undetectable
6ce2B-5f7cA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3k SLR0280 PROTEIN

(Synechocystis
sp. PCC 6803)
no annotation 5 LEU A  93
GLY A  84
GLY A  81
GLY A  79
ARG A 117
None
1.12A 6ce2B-5h3kA:
undetectable
6ce2B-5h3kA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inr DIPEPTIDASE

(Lactobacillus
farciminis)
PF03577
(Peptidase_C69)
5 LEU A 214
LEU A 211
GLY A 172
GLY A 234
ARG A 230
None
None
None
EDO  A 509 (-4.2A)
None
0.84A 6ce2B-5inrA:
undetectable
6ce2B-5inrA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ktk POLYKETIDE SYNTHASE
PKSJ


(Bacillus
subtilis)
PF08659
(KR)
5 LEU A 221
LEU A 247
GLY A 231
GLY A 226
GLY A 251
None
None
None
NDP  A 601 ( 4.9A)
NDP  A 601 (-3.6A)
1.11A 6ce2B-5ktkA:
undetectable
6ce2B-5ktkA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nck N-ACETYLMANNOSAMINE
KINASE


(Fusobacterium
nucleatum)
PF00480
(ROK)
5 LEU A 146
GLY A 279
GLY A 114
GLY A 119
ASN A 126
None
1.06A 6ce2B-5nckA:
undetectable
6ce2B-5nckA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5owc -

(-)
no annotation 5 LEU A   5
GLY A  28
GLY A  30
TYR A  50
PRO A  60
AYZ  A 202 (-4.6A)
AYZ  A 202 ( 3.5A)
AYZ  A 202 ( 3.6A)
AYZ  A 202 ( 4.9A)
None
0.76A 6ce2B-5owcA:
18.9
6ce2B-5owcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5owc -

(-)
no annotation 5 LEU A   5
GLY A  28
TYR A  50
PRO A  60
LYS A  61
AYZ  A 202 (-4.6A)
AYZ  A 202 ( 3.5A)
AYZ  A 202 ( 4.9A)
None
None
0.88A 6ce2B-5owcA:
18.9
6ce2B-5owcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tnv AP ENDONUCLEASE,
FAMILY PROTEIN 2


(Mycolicibacterium
smegmatis)
PF01261
(AP_endonuc_2)
5 LEU A 151
LEU A 148
GLY A  96
GLY A 121
TYR A 179
None
1.05A 6ce2B-5tnvA:
undetectable
6ce2B-5tnvA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ul4 OXSB PROTEIN

(Bacillus
megaterium)
PF02310
(B12-binding)
5 LEU A 147
LEU A 152
GLY A 241
ASN A  58
LYS A 149
None
None
B12  A 802 (-3.5A)
None
None
0.98A 6ce2B-5ul4A:
undetectable
6ce2B-5ul4A:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE


(Clostridium
perfringens)
PF00478
(IMPDH)
5 LEU A  15
GLY A 343
GLY A 433
ASN A  19
PRO A  18
None
1.12A 6ce2B-5uzeA:
undetectable
6ce2B-5uzeA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlh PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9


(Homo sapiens)
PF00082
(Peptidase_S8)
PF05922
(Inhibitor_I9)
5 LEU A 304
LEU A 118
GLY A 267
GLY A 263
ASN A 298
None
1.13A 6ce2B-5vlhA:
undetectable
6ce2B-5vlhA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvo DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1


(Homo sapiens)
no annotation 5 GLY C 471
GLY C 468
LYS C 510
TYR C 507
PRO C 537
None
1.10A 6ce2B-5wvoC:
undetectable
6ce2B-5wvoC:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wzm GROUP IIE SECRETORY
PHOSPHOLIPASE A2


(Homo sapiens)
no annotation 5 GLY A  28
GLY A  30
TYR A  50
PRO A  60
LYS A  61
CA  A 210 (-4.3A)
CA  A 210 (-4.2A)
None
CL  A 201 (-3.7A)
CL  A 201 (-4.0A)
0.98A 6ce2B-5wzmA:
18.5
6ce2B-5wzmA:
29.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ypz COFB

(Escherichia
coli)
no annotation 5 GLY A 106
GLY A 104
ARG A 110
ASN A  82
PRO A  79
None
1.14A 6ce2B-5ypzA:
undetectable
6ce2B-5ypzA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5c CYSTEINE SYNTHASE

(Fusobacterium
nucleatum)
no annotation 5 LEU A 216
GLY A 186
GLY A 184
GLY A 229
ASN A 212
None
PLP  A 401 (-3.5A)
PLP  A 401 (-3.6A)
PLP  A 401 (-3.6A)
None
1.06A 6ce2B-5z5cA:
undetectable
6ce2B-5z5cA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cgm RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE


(Bacillus
subtilis)
no annotation 5 LEU A 203
LEU A 251
GLY A 225
GLY A 222
GLY A 210
None
1.07A 6ce2B-6cgmA:
undetectable
6ce2B-6cgmA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gy5 -

(-)
no annotation 5 LEU A 320
GLY A 548
GLY A 595
GLY A 359
ARG A 355
None
EDO  A 710 (-3.3A)
EDO  A 710 (-3.2A)
None
None
1.04A 6ce2B-6gy5A:
undetectable
6ce2B-6gy5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gy5 -

(-)
no annotation 5 LEU A 556
GLY A 501
GLY A 548
GLY A 595
ARG A 591
None
None
EDO  A 710 (-3.3A)
EDO  A 710 (-3.2A)
None
1.12A 6ce2B-6gy5A:
undetectable
6ce2B-6gy5A:
undetectable