SIMILAR PATTERNS OF AMINO ACIDS FOR 6CE2_B_SVRB202_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ad6 RETINOBLASTOMA TUMOR
SUPPRESSOR

(Homo sapiens) 		PF01858
(RB_A) 		5 LEU A 521
LEU A 487
LEU A 512
ARG A 445
TYR A 446
 None
 1.43A 6ce2A-1ad6A:
0.0		 6ce2A-1ad6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b9b PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)

(Thermotoga
maritima) 		PF00121
(TIM) 		4 LEU A 195
LEU A 194
LEU A 155
GLY A 154
 None
 0.94A 6ce2A-1b9bA:
0.0		 6ce2A-1b9bA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhg BETA-GLUCURONIDASE

(Homo sapiens) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 LEU A 621
LEU A 622
LEU A 571
GLY A 572
 None
 0.67A 6ce2A-1bhgA:
0.0		 6ce2A-1bhgA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bue PROTEIN
(IMIPENEM-HYDROLYSIN
G BETA-LACTAMASE)

(Enterobacter
cloacae) 		PF13354
(Beta-lactamase2) 		4 LEU A 119
LEU A  89
LEU A 139
GLY A 144
 None
 0.79A 6ce2A-1bueA:
undetectable		 6ce2A-1bueA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c05 RIBOSOMAL PROTEIN S4
DELTA 41

(Geobacillus
stearothermophilus) 		PF00163
(Ribosomal_S4)
PF01479
(S4) 		4 LEU A  62
LEU A  60
LEU A  79
GLY A  82
 None
 0.92A 6ce2A-1c05A:
0.0		 6ce2A-1c05A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cj2 PROTEIN
(P-HYDROXYBENZOATE
HYDROXYLASE)

(Pseudomonas
fluorescens) 		PF01494
(FAD_binding_3) 		4 LEU A 210
LEU A 199
GLY A 298
TYR A 385
 None
None
FAD  A 395 (-3.4A)
None
 0.95A 6ce2A-1cj2A:
undetectable		 6ce2A-1cj2A:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddm NUMB PROTEIN

(Drosophila
melanogaster) 		PF00640
(PID) 		4 LEU A 128
LEU A 178
GLY A 159
TYR A 162
 None
 0.91A 6ce2A-1ddmA:
undetectable		 6ce2A-1ddmA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ekb ENTEROPEPTIDASE

(Bos taurus) 		PF00089
(Trypsin) 		4 LEU B 144
LEU B 155
ARG B  23
LYS B  16
 None
 0.90A 6ce2A-1ekbB:
0.0		 6ce2A-1ekbB:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fpo CHAPERONE PROTEIN
HSCB

(Escherichia
coli) 		PF07743
(HSCB_C) 		4 LEU A  71
LEU A  74
LEU A   9
GLY A   8
 None
 0.81A 6ce2A-1fpoA:
2.5		 6ce2A-1fpoA:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1god PROTEIN
(PHOSPHOLIPASE A2)

(Cerrophidion
godmani) 		PF00068
(Phospholip_A2_1) 		4 LEU A   5
GLY A  32
ARG A  34
TYR A  52
 None
 0.94A 6ce2A-1godA:
21.5		 6ce2A-1godA:
72.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hzo BETA-LACTAMASE

(Proteus
vulgaris) 		PF13354
(Beta-lactamase2) 		4 LEU A 119
LEU A  90
LEU A 139
GLY A 144
 None
 0.95A 6ce2A-1hzoA:
undetectable		 6ce2A-1hzoA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iq0 ARGINYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		4 LEU A 220
LEU A 221
GLY A 331
TYR A 328
 None
 0.89A 6ce2A-1iq0A:
undetectable		 6ce2A-1iq0A:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iqr PHOTOLYASE

(Thermus
thermophilus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 LEU A 172
LEU A 174
LEU A 339
GLY A 342
 None
None
FAD  A 421 (-4.6A)
FAD  A 421 (-3.5A)
 0.90A 6ce2A-1iqrA:
undetectable		 6ce2A-1iqrA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixr HOLLIDAY JUNCTION
DNA HELICASE RUVA

(Thermus
thermophilus) 		PF01330
(RuvA_N)
PF14520
(HHH_5) 		4 LEU A  28
LEU A  59
LEU A  20
GLY A  22
 None
 0.89A 6ce2A-1ixrA:
undetectable		 6ce2A-1ixrA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixr HOLLIDAY JUNCTION
DNA HELICASE RUVA

(Thermus
thermophilus) 		PF01330
(RuvA_N)
PF14520
(HHH_5) 		4 LEU A  28
LEU A  59
LEU A  20
GLY A  23
 None
 0.88A 6ce2A-1ixrA:
undetectable		 6ce2A-1ixrA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j33 COBT

(Thermus
thermophilus) 		PF02277
(DBI_PRT) 		4 LEU A 249
LEU A 245
GLY A 244
TYR A 237
 None
 0.92A 6ce2A-1j33A:
undetectable		 6ce2A-1j33A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqp DIPEPTIDYL PEPTIDASE
I

(Rattus
norvegicus) 		PF00112
(Peptidase_C1)
PF08773
(CathepsinC_exc) 		4 LEU A  47
LYS A 371
TYR A   8
LYS A  45
 None
 0.84A 6ce2A-1jqpA:
undetectable		 6ce2A-1jqpA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5a AMIDE SYNTHASE

(Vibrio cholerae) 		PF00668
(Condensation) 		4 LEU A   2
LEU A 129
GLY A 133
TYR A 161
 None
 0.91A 6ce2A-1l5aA:
undetectable		 6ce2A-1l5aA:
12.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mc2 ACUTOHAEMONLYSIN

(Deinagkistrodon
acutus) 		PF00068
(Phospholip_A2_1) 		6 LEU A1002
LEU A1005
GLY A1033
ARG A1034
LYS A1049
TYR A1052
 IPA  A1136 ( 4.7A)
IPA  A1135 ( 4.2A)
None
None
None
None
 0.78A 6ce2A-1mc2A:
23.1		 6ce2A-1mc2A:
72.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mc2 ACUTOHAEMONLYSIN

(Deinagkistrodon
acutus) 		PF00068
(Phospholip_A2_1) 		6 LEU A1002
LEU A1005
GLY A1033
LYS A1049
TYR A1052
LYS A1069
 IPA  A1136 ( 4.7A)
IPA  A1135 ( 4.2A)
None
None
None
None
 0.64A 6ce2A-1mc2A:
23.1		 6ce2A-1mc2A:
72.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxz HYPOTHETICAL PROTEIN
HI0303

(Haemophilus
influenzae) 		PF04452
(Methyltrans_RNA) 		4 LEU A 169
LEU A 192
LEU A 217
GLY A 219
 None
 0.91A 6ce2A-1nxzA:
undetectable		 6ce2A-1nxzA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		4 LEU A  49
LEU A  17
GLY A  95
TYR A 174
 None
None
NAP  A1800 (-3.2A)
None
 0.94A 6ce2A-1o2dA:
undetectable		 6ce2A-1o2dA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pg5 ASPARTATE
CARBAMOYLTRANSFERASE

(Sulfolobus
acidocaldarius) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 LEU A 167
LEU A 168
LEU A 150
TYR A 199
 None
 0.95A 6ce2A-1pg5A:
undetectable		 6ce2A-1pg5A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q50 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Leishmania
mexicana) 		PF00342
(PGI) 		4 LEU A 368
LEU A 372
LEU A 528
GLY A 460
 None
 0.84A 6ce2A-1q50A:
undetectable		 6ce2A-1q50A:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8y GLYCINE
N-METHYLTRANSFERASE

(Mus musculus) 		PF13847
(Methyltransf_31) 		4 LEU A  74
LEU A 169
GLY A 168
ARG A 165
 None
 0.94A 6ce2A-1r8yA:
undetectable		 6ce2A-1r8yA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rc2 AQUAPORIN Z

(Escherichia
coli) 		no annotation 4 LEU B 227
LEU B 226
LEU B 146
GLY B 216
 None
 0.90A 6ce2A-1rc2B:
undetectable		 6ce2A-1rc2B:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sjp 60 KDA CHAPERONIN 2

(Mycobacterium
tuberculosis) 		PF00118
(Cpn60_TCP1) 		4 LEU A 234
LEU A 231
LEU A 256
GLY A 253
 None
 0.80A 6ce2A-1sjpA:
2.1		 6ce2A-1sjpA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1smq RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SMALL CHAIN 1

(Saccharomyces
cerevisiae) 		PF00268
(Ribonuc_red_sm) 		4 LEU A 338
LEU A 339
LEU A 232
GLY A 229
 None
 0.88A 6ce2A-1smqA:
undetectable		 6ce2A-1smqA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1taq TAQ DNA POLYMERASE

(Thermus
aquaticus) 		PF00476
(DNA_pol_A)
PF01367
(5_3_exonuc)
PF02739
(5_3_exonuc_N)
PF09281
(Taq-exonuc) 		4 LEU A 311
LEU A 321
LEU A 351
GLY A 350
 None
 0.93A 6ce2A-1taqA:
undetectable		 6ce2A-1taqA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1thx THIOREDOXIN

(Nostoc sp. PCC
7120) 		PF00085
(Thioredoxin) 		4 LEU A  99
LEU A 100
GLY A   3
TYR A  49
 None
 0.90A 6ce2A-1thxA:
undetectable		 6ce2A-1thxA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1twd COPPER HOMEOSTASIS
PROTEIN CUTC

(Shigella
flexneri) 		PF03932
(CutC) 		4 LEU A 137
LEU A 134
LEU A 146
GLY A 176
 None
 0.89A 6ce2A-1twdA:
undetectable		 6ce2A-1twdA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkx PROTEIN (NF-KAPPA B
P50 SUBUNIT)

(Mus musculus) 		PF00554
(RHD_DNA_bind)
PF16179
(RHD_dimer) 		4 LEU B 512
LEU B 397
GLY B 365
ARG B 356
 None
 0.92A 6ce2A-1vkxB:
undetectable		 6ce2A-1vkxB:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdt ELONGATION FACTOR G
HOMOLOG

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		4 LEU A 247
LEU A 246
LEU A 219
GLY A 218
 None
 0.83A 6ce2A-1wdtA:
undetectable		 6ce2A-1wdtA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wqa PHOSPHO-SUGAR MUTASE

(Pyrococcus
horikoshii) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 LEU A  34
LEU A  33
LEU A 113
GLY A 119
 LEU  A  34 ( 0.6A)
LEU  A  33 ( 0.6A)
LEU  A 113 ( 0.6A)
GLY  A 119 ( 0.0A)
 0.77A 6ce2A-1wqaA:
undetectable		 6ce2A-1wqaA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3l HYPOTHETICAL PROTEIN
PH0495

(Pyrococcus
horikoshii) 		PF05161
(MOFRL)
PF13660
(DUF4147) 		4 LEU A 146
LEU A 149
LEU A 136
GLY A 132
 None
None
None
SO4  A 505 (-3.3A)
 0.95A 6ce2A-1x3lA:
undetectable		 6ce2A-1x3lA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xtj PROBABLE
ATP-DEPENDENT RNA
HELICASE P47

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 LEU A 161
LEU A 177
GLY A 174
LYS A 183
 None
 0.87A 6ce2A-1xtjA:
undetectable		 6ce2A-1xtjA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y1p ALDEHYDE REDUCTASE
II

(Sporidiobolus
salmonicolor) 		PF01370
(Epimerase) 		4 LEU A 113
LEU A 116
LEU A 186
ARG A 270
 None
 0.81A 6ce2A-1y1pA:
undetectable		 6ce2A-1y1pA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ya5 TELETHONIN

(Homo sapiens) 		PF09470
(Telethonin) 		4 LEU T  28
LEU T  30
GLY T  77
ARG T  76
 None
 0.74A 6ce2A-1ya5T:
undetectable		 6ce2A-1ya5T:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcl PROTEIN TYROSINE
PHOSPHATASE 4A1

(Rattus
norvegicus) 		PF00782
(DSPc) 		4 LEU A 146
LEU A 149
LEU A 108
GLY A 107
 None
None
SO4  A4398 (-4.2A)
SO4  A4398 (-3.4A)
 0.77A 6ce2A-1zclA:
undetectable		 6ce2A-1zclA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2

(Homo sapiens) 		PF00632
(HECT) 		5 LEU A 513
LEU A 512
LEU A 624
GLY A 628
ARG A 680
 None
 1.12A 6ce2A-1zvdA:
undetectable		 6ce2A-1zvdA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ayn UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 14

(Homo sapiens) 		PF00443
(UCH) 		4 LEU A 350
LEU A 419
GLY A 467
ARG A 329
 None
 0.92A 6ce2A-2aynA:
undetectable		 6ce2A-2aynA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c6s ADENOVIRUS 2,12
PENTON BASE CHIMERA

(Human
mastadenovirus
C) 		PF01686
(Adeno_Penton_B) 		4 LEU A 242
LEU A 243
GLY A 260
LYS A 209
 None
 0.90A 6ce2A-2c6sA:
undetectable		 6ce2A-2c6sA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cuy MALONYL COA-[ACYL
CARRIER PROTEIN]
TRANSACYLASE

(Thermus
thermophilus) 		PF00698
(Acyl_transf_1) 		4 LEU A  44
LEU A  41
GLY A 115
ARG A 114
 None
 0.90A 6ce2A-2cuyA:
0.9		 6ce2A-2cuyA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cuy MALONYL COA-[ACYL
CARRIER PROTEIN]
TRANSACYLASE

(Thermus
thermophilus) 		PF00698
(Acyl_transf_1) 		4 LEU A 205
LEU A 209
LEU A  90
GLY A  91
 None
 0.93A 6ce2A-2cuyA:
0.9		 6ce2A-2cuyA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw7 ENDONUCLEASE
PI-PKOII

(Thermococcus
kodakarensis) 		PF14528
(LAGLIDADG_3)
PF14890
(Intein_splicing) 		4 LEU A 401
LEU A 400
LEU A 282
LYS A 358
 None
 0.93A 6ce2A-2cw7A:
undetectable		 6ce2A-2cw7A:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ejw HOMOSERINE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		4 LEU A 134
LEU A 131
GLY A 207
ARG A 110
 None
 0.91A 6ce2A-2ejwA:
undetectable		 6ce2A-2ejwA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ell ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER B

(Homo sapiens) 		PF14580
(LRR_9) 		4 LEU A 146
LEU A 122
GLY A  86
LYS A 117
 None
 0.70A 6ce2A-2ellA:
undetectable		 6ce2A-2ellA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3n SH3 AND MULTIPLE
ANKYRIN REPEAT
DOMAINS 3

(Rattus
norvegicus) 		PF00536
(SAM_1) 		4 LEU A  65
LEU A  62
GLY A  11
LYS A   1
 None
 0.95A 6ce2A-2f3nA:
undetectable		 6ce2A-2f3nA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A

(Archaeoglobus
fulgidus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 LEU A 343
LEU A 278
GLY A 142
ARG A  85
 None
 0.81A 6ce2A-2fjaA:
1.4		 6ce2A-2fjaA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g2o MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Escherichia
coli) 		PF00698
(Acyl_transf_1) 		4 LEU A  47
LEU A  44
GLY A 118
ARG A 117
 None
None
None
SO4  A1001 (-2.9A)
 0.85A 6ce2A-2g2oA:
undetectable		 6ce2A-2g2oA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2q BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Trypanosoma
cruzi) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 LEU A 112
LEU A 109
GLY A  93
LYS A 117
 None
 0.80A 6ce2A-2h2qA:
undetectable		 6ce2A-2h2qA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6e D-ARABINOSE
1-DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 137
LEU A 140
GLY A  39
ARG A 339
 None
 0.82A 6ce2A-2h6eA:
undetectable		 6ce2A-2h6eA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id5 LEUCINE RICH REPEAT
NEURONAL 6A

(Homo sapiens) 		PF07679
(I-set)
PF13306
(LRR_5)
PF13855
(LRR_8) 		4 LEU A 154
LEU A 130
LEU A 159
GLY A 136
 None
 0.87A 6ce2A-2id5A:
undetectable		 6ce2A-2id5A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ija ARYLAMINE
N-ACETYLTRANSFERASE
1

(Homo sapiens) 		PF00797
(Acetyltransf_2) 		4 LEU A 152
LEU A 137
GLY A  90
ARG A 197
 None
 0.93A 6ce2A-2ijaA:
undetectable		 6ce2A-2ijaA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT

(Aromatoleum
aromaticum) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 LEU A 506
LEU A 491
GLY A 201
TYR A 208
 None
 0.94A 6ce2A-2ivfA:
undetectable		 6ce2A-2ivfA:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		4 LEU A 791
LEU A 554
GLY A 594
TYR A 758
 None
 0.95A 6ce2A-2jgdA:
1.7		 6ce2A-2jgdA:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kso PHOSPHATIDYLINOSITOL
-3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo sapiens) 		PF00536
(SAM_1) 		4 LEU B  56
LEU B  53
LEU B  38
GLY B  37
 None
 0.76A 6ce2A-2ksoB:
undetectable		 6ce2A-2ksoB:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lsu TPR
REPEAT-CONTAINING
PROTEIN ASSOCIATED
WITH HSP90

(Saccharomyces
cerevisiae) 		PF14559
(TPR_19) 		4 LEU A  51
LEU A  48
LEU A  14
GLY A  11
 None
 0.93A 6ce2A-2lsuA:
undetectable		 6ce2A-2lsuA:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mzc GLUTAREDOXIN

(Brucella
melitensis) 		PF00462
(Glutaredoxin) 		4 LEU A  26
LEU A  25
GLY A  68
LYS A  23
 None
 0.95A 6ce2A-2mzcA:
undetectable		 6ce2A-2mzcA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2na0 GUANYLYL
CYCLASE-ACTIVATING
PROTEIN 1

(Bos taurus) 		PF00036
(EF-hand_1)
PF13499
(EF-hand_7) 		4 LEU A 166
LEU A 170
LEU A 113
ARG A 117
 None
 0.92A 6ce2A-2na0A:
undetectable		 6ce2A-2na0A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 LEU A 300
LEU A 301
LEU A 256
GLY A 255
 None
 0.89A 6ce2A-2nq5A:
undetectable		 6ce2A-2nq5A:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvn HYPOTHETICAL PROTEIN

(Synechococcus
elongatus) 		PF08848
(DUF1818) 		4 LEU A  93
LEU A  76
LEU A  25
GLY A  14
 None
 0.59A 6ce2A-2nvnA:
undetectable		 6ce2A-2nvnA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4c ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
PF11890
(DUF3410) 		4 LEU A 103
LEU A 104
GLY A 137
ARG A 370
 None
 0.95A 6ce2A-2o4cA:
undetectable		 6ce2A-2o4cA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ojq PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN

(Homo sapiens) 		PF13949
(ALIX_LYPXL_bnd) 		4 LEU A 401
LEU A 399
LEU A 625
GLY A 624
 None
 0.95A 6ce2A-2ojqA:
undetectable		 6ce2A-2ojqA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjc DIADENOSINE
TETRAPHOSPHATASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00149
(Metallophos) 		4 LEU A 111
LEU A 108
LEU A  56
GLY A  54
 None
 0.82A 6ce2A-2qjcA:
undetectable		 6ce2A-2qjcA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qm8 GTPASE/ATPASE

(Methylobacterium
extorquens) 		PF03308
(ArgK) 		4 LEU A  15
LEU A  23
GLY A  53
ARG A  57
 None
 0.93A 6ce2A-2qm8A:
undetectable		 6ce2A-2qm8A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rb9 HYPE PROTEIN

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 LEU A 196
LEU A 192
LEU A 264
GLY A 263
 None
 0.90A 6ce2A-2rb9A:
undetectable		 6ce2A-2rb9A:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rex PLEXIN-B1

(Homo sapiens) 		PF08337
(Plexin_cytopl) 		4 LEU A1785
LEU A1788
GLY A1758
LYS A1781
 None
None
None
UNX  A  11 (-3.5A)
 0.94A 6ce2A-2rexA:
undetectable		 6ce2A-2rexA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v8p 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE

(Aquifex
aeolicus) 		PF00288
(GHMP_kinases_N) 		4 LEU A 123
LEU A 120
LEU A  61
GLY A  96
 None
None
ADP  A1270 (-3.9A)
ADP  A1270 (-3.4A)
 0.93A 6ce2A-2v8pA:
undetectable		 6ce2A-2v8pA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9k UNCHARACTERIZED
PROTEIN FLJ32312

(Homo sapiens) 		no annotation 4 LEU A 350
GLY A 351
ARG A 390
TYR A 294
 None
 0.95A 6ce2A-2v9kA:
undetectable		 6ce2A-2v9kA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vi7 ACETYLTRANSFERASE
PA1377

(Pseudomonas
aeruginosa) 		PF00583
(Acetyltransf_1) 		4 LEU A  21
LEU A  24
LEU A  61
ARG A 105
 None
 0.94A 6ce2A-2vi7A:
undetectable		 6ce2A-2vi7A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU C 290
LEU C 252
GLY C 251
ARG C 147
 None
 0.93A 6ce2A-2wtkC:
undetectable		 6ce2A-2wtkC:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8u SERINE
PALMITOYLTRANSFERASE

(Sphingomonas
wittichii) 		PF00155
(Aminotran_1_2) 		4 LEU A 347
LEU A 352
GLY A 312
ARG A 308
 None
 0.94A 6ce2A-2x8uA:
undetectable		 6ce2A-2x8uA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xes PROTEIN PAT1 HOMOLOG
1

(Homo sapiens) 		PF09770
(PAT1) 		4 LEU A 689
LEU A 686
LEU A 726
LYS A 762
 None
 0.85A 6ce2A-2xesA:
undetectable		 6ce2A-2xesA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1

(Homo sapiens) 		PF01026
(TatD_DNase) 		4 LEU A 209
LEU A 206
LEU A 267
ARG A 239
 None
 0.93A 6ce2A-2xioA:
undetectable		 6ce2A-2xioA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT

(Thermus
thermophilus) 		PF01174
(SNO) 		4 LEU A  43
LEU A  37
GLY A  54
ARG A  58
 None
 0.87A 6ce2A-2ywdA:
undetectable		 6ce2A-2ywdA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxz THIAMIN-MONOPHOSPHAT
E KINASE

(Thermus
thermophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 LEU A 298
LEU A 303
GLY A 162
TYR A 254
 None
 0.82A 6ce2A-2yxzA:
undetectable		 6ce2A-2yxzA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6g B-CATENIN

(Danio rerio) 		PF00514
(Arm) 		4 LEU A 404
LEU A 369
GLY A 360
ARG A 328
 None
 0.91A 6ce2A-2z6gA:
undetectable		 6ce2A-2z6gA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Bifidobacterium
longum) 		PF01547
(SBP_bac_1) 		4 LEU A 344
LEU A 151
GLY A 150
TYR A  46
 None
 0.95A 6ce2A-2z8eA:
undetectable		 6ce2A-2z8eA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zpb NITRILE HYDRATASE
SUBUNIT ALPHA
NITRILE HYDRATASE
SUBUNIT BETA

(Rhodococcus
erythropolis) 		PF02211
(NHase_beta)
PF02979
(NHase_alpha) 		4 LEU B  95
LEU B  98
LEU A  34
GLY A  33
 None
 0.93A 6ce2A-2zpbB:
undetectable		 6ce2A-2zpbB:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae) 		PF00202
(Aminotran_3) 		4 LEU A  88
LEU A 310
LEU A 273
GLY A 272
 None
 0.90A 6ce2A-2zukA:
undetectable		 6ce2A-2zukA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3amj ZINC PEPTIDASE
ACTIVE SUBUNIT

(Sphingomonas
sp. A1) 		no annotation 4 LEU C 407
GLY C 406
ARG C  62
TYR C 114
 None
 0.88A 6ce2A-3amjC:
undetectable		 6ce2A-3amjC:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3apq DNAJ HOMOLOG
SUBFAMILY C MEMBER
10

(Mus musculus) 		PF00085
(Thioredoxin)
PF00226
(DnaJ) 		4 LEU A  39
LEU A  40
LEU A  78
GLY A 110
 None
 0.94A 6ce2A-3apqA:
1.3		 6ce2A-3apqA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)

(Thermus
thermophilus) 		PF14520
(HHH_5)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb) 		4 LEU A 306
LEU A 324
LEU A 278
GLY A 277
 None
 0.95A 6ce2A-3auoA:
undetectable		 6ce2A-3auoA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw8 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Thermus
thermophilus) 		PF02222
(ATP-grasp) 		4 LEU A  14
LEU A 289
GLY A 288
ARG A 189
 None
 0.92A 6ce2A-3aw8A:
undetectable		 6ce2A-3aw8A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b46 AMINOTRANSFERASE
BNA3

(Saccharomyces
cerevisiae) 		PF00155
(Aminotran_1_2) 		4 LEU A 101
LEU A 104
GLY A 270
LYS A 272
 None
None
LLP  A 271 ( 2.4A)
LLP  A 271 ( 3.1A)
 0.89A 6ce2A-3b46A:
undetectable		 6ce2A-3b46A:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5i S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE-LI
KE PROTEIN

(Arabidopsis
thaliana) 		PF03492
(Methyltransf_7) 		4 LEU A 160
GLY A 139
ARG A 143
TYR A 142
 None
None
None
SAH  A 401 (-4.2A)
 0.84A 6ce2A-3b5iA:
undetectable		 6ce2A-3b5iA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b89 16S RRNA METHYLASE

(Escherichia
coli) 		PF07091
(FmrO) 		4 LEU A  91
LEU A  94
LEU A 114
GLY A 113
 None
None
None
5GP  A 500 ( 4.5A)
 0.90A 6ce2A-3b89A:
undetectable		 6ce2A-3b89A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4n UNCHARACTERIZED
PROTEIN DR_0571

(Deinococcus
radiodurans) 		PF01266
(DAO) 		4 LEU A 317
LEU A 318
LEU A 260
GLY A 335
 None
 0.82A 6ce2A-3c4nA:
0.7		 6ce2A-3c4nA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwr TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Rhodospirillum
rubrum) 		PF00440
(TetR_N) 		4 LEU A 109
LEU A 113
LEU A  63
GLY A  59
 None
 0.86A 6ce2A-3cwrA:
undetectable		 6ce2A-3cwrA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cyv UROPORPHYRINOGEN
DECARBOXYLASE

(Shigella
flexneri) 		PF01208
(URO-D) 		4 LEU A  61
LEU A  64
LEU A  74
GLY A 143
 None
 0.83A 6ce2A-3cyvA:
undetectable		 6ce2A-3cyvA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3doa FIBRINOGEN BINDING
PROTEIN

(Staphylococcus
aureus) 		PF05833
(FbpA) 		4 LEU A 273
LEU A   6
GLY A   5
ARG A  97
 None
 0.95A 6ce2A-3doaA:
undetectable		 6ce2A-3doaA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3drn PEROXIREDOXIN,
BACTERIOFERRITIN
COMIGRATORY PROTEIN
HOMOLOG

(Sulfolobus
solfataricus) 		PF00578
(AhpC-TSA) 		4 LEU A  10
LEU A  23
GLY A   5
TYR A 102
 None
 0.83A 6ce2A-3drnA:
undetectable		 6ce2A-3drnA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dsg TYPE IV FIMBRIAE
ASSEMBLY PROTEIN

(Xanthomonas
campestris) 		PF07238
(PilZ) 		4 LEU A  15
LEU A  54
GLY A  32
ARG A  97
 None
 0.95A 6ce2A-3dsgA:
undetectable		 6ce2A-3dsgA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ekg MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Azotobacter
vinelandii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 384
LEU A 359
LEU A  61
TYR A 325
 None
 0.94A 6ce2A-3ekgA:
undetectable		 6ce2A-3ekgA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fai BETA-LACTAMASE

(Aeromonas
hydrophila) 		PF00753
(Lactamase_B) 		4 LEU A 217
LEU A 254
GLY A 193
ARG A 248
 None
 0.95A 6ce2A-3faiA:
undetectable		 6ce2A-3faiA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpz THIAZOLE
BIOSYNTHETIC ENZYME

(Saccharomyces
cerevisiae) 		PF01946
(Thi4) 		4 LEU A 129
LEU A 126
LEU A  78
GLY A  74
 None
None
None
AHZ  A1100 (-3.6A)
 0.92A 6ce2A-3fpzA:
undetectable		 6ce2A-3fpzA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5a FMN
ADENYLYLTRANSFERASE

([Candida]
glabrata) 		PF01507
(PAPS_reduct) 		4 LEU A 130
LEU A 132
LEU A  70
GLY A 163
 None
None
None
APC  A 305 (-3.2A)
 0.90A 6ce2A-3g5aA:
undetectable		 6ce2A-3g5aA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hl0 MALEYLACETATE
REDUCTASE

(Agrobacterium
fabrum) 		PF00465
(Fe-ADH) 		4 LEU A 179
LEU A 279
LEU A 225
GLY A 222
 None
 0.90A 6ce2A-3hl0A:
1.1		 6ce2A-3hl0A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i16 ALUMINUM RESISTANCE
PROTEIN

(Clostridium
novyi) 		PF06838
(Met_gamma_lyase) 		4 LEU A 107
LEU A 103
GLY A 122
TYR A 125
 None
None
None
TLA  A 427 (-4.5A)
 0.95A 6ce2A-3i16A:
1.8		 6ce2A-3i16A:
16.76