SIMILAR PATTERNS OF AMINO ACIDS FOR 6CE2_B_SVRB202

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ad6 RETINOBLASTOMA TUMOR
SUPPRESSOR

(Homo sapiens) 		PF01858
(RB_A) 		5 LEU A 521
LEU A 487
LEU A 512
ARG A 445
TYR A 446
 None
 1.43A 6ce2A-1ad6A:
0.0		 6ce2A-1ad6A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b9b PROTEIN
(TRIOSEPHOSPHATE
ISOMERASE)

(Thermotoga
maritima) 		PF00121
(TIM) 		4 LEU A 195
LEU A 194
LEU A 155
GLY A 154
 None
 0.94A 6ce2A-1b9bA:
0.0		 6ce2A-1b9bA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bhg BETA-GLUCURONIDASE

(Homo sapiens) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 LEU A 621
LEU A 622
LEU A 571
GLY A 572
 None
 0.67A 6ce2A-1bhgA:
0.0		 6ce2A-1bhgA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bue PROTEIN
(IMIPENEM-HYDROLYSIN
G BETA-LACTAMASE)

(Enterobacter
cloacae) 		PF13354
(Beta-lactamase2) 		4 LEU A 119
LEU A  89
LEU A 139
GLY A 144
 None
 0.79A 6ce2A-1bueA:
undetectable		 6ce2A-1bueA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c05 RIBOSOMAL PROTEIN S4
DELTA 41

(Geobacillus
stearothermophilus) 		PF00163
(Ribosomal_S4)
PF01479
(S4) 		4 LEU A  62
LEU A  60
LEU A  79
GLY A  82
 None
 0.92A 6ce2A-1c05A:
0.0		 6ce2A-1c05A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cj2 PROTEIN
(P-HYDROXYBENZOATE
HYDROXYLASE)

(Pseudomonas
fluorescens) 		PF01494
(FAD_binding_3) 		4 LEU A 210
LEU A 199
GLY A 298
TYR A 385
 None
None
FAD  A 395 (-3.4A)
None
 0.95A 6ce2A-1cj2A:
undetectable		 6ce2A-1cj2A:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ddm NUMB PROTEIN

(Drosophila
melanogaster) 		PF00640
(PID) 		4 LEU A 128
LEU A 178
GLY A 159
TYR A 162
 None
 0.91A 6ce2A-1ddmA:
undetectable		 6ce2A-1ddmA:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ekb ENTEROPEPTIDASE

(Bos taurus) 		PF00089
(Trypsin) 		4 LEU B 144
LEU B 155
ARG B  23
LYS B  16
 None
 0.90A 6ce2A-1ekbB:
0.0		 6ce2A-1ekbB:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fpo CHAPERONE PROTEIN
HSCB

(Escherichia
coli) 		PF07743
(HSCB_C) 		4 LEU A  71
LEU A  74
LEU A   9
GLY A   8
 None
 0.81A 6ce2A-1fpoA:
2.5		 6ce2A-1fpoA:
16.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1god PROTEIN
(PHOSPHOLIPASE A2)

(Cerrophidion
godmani) 		PF00068
(Phospholip_A2_1) 		4 LEU A   5
GLY A  32
ARG A  34
TYR A  52
 None
 0.94A 6ce2A-1godA:
21.5		 6ce2A-1godA:
72.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hzo BETA-LACTAMASE

(Proteus
vulgaris) 		PF13354
(Beta-lactamase2) 		4 LEU A 119
LEU A  90
LEU A 139
GLY A 144
 None
 0.95A 6ce2A-1hzoA:
undetectable		 6ce2A-1hzoA:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iq0 ARGINYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1) 		4 LEU A 220
LEU A 221
GLY A 331
TYR A 328
 None
 0.89A 6ce2A-1iq0A:
undetectable		 6ce2A-1iq0A:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iqr PHOTOLYASE

(Thermus
thermophilus) 		PF00875
(DNA_photolyase)
PF03441
(FAD_binding_7) 		4 LEU A 172
LEU A 174
LEU A 339
GLY A 342
 None
None
FAD  A 421 (-4.6A)
FAD  A 421 (-3.5A)
 0.90A 6ce2A-1iqrA:
undetectable		 6ce2A-1iqrA:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixr HOLLIDAY JUNCTION
DNA HELICASE RUVA

(Thermus
thermophilus) 		PF01330
(RuvA_N)
PF14520
(HHH_5) 		4 LEU A  28
LEU A  59
LEU A  20
GLY A  22
 None
 0.89A 6ce2A-1ixrA:
undetectable		 6ce2A-1ixrA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixr HOLLIDAY JUNCTION
DNA HELICASE RUVA

(Thermus
thermophilus) 		PF01330
(RuvA_N)
PF14520
(HHH_5) 		4 LEU A  28
LEU A  59
LEU A  20
GLY A  23
 None
 0.88A 6ce2A-1ixrA:
undetectable		 6ce2A-1ixrA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j33 COBT

(Thermus
thermophilus) 		PF02277
(DBI_PRT) 		4 LEU A 249
LEU A 245
GLY A 244
TYR A 237
 None
 0.92A 6ce2A-1j33A:
undetectable		 6ce2A-1j33A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqp DIPEPTIDYL PEPTIDASE
I

(Rattus
norvegicus) 		PF00112
(Peptidase_C1)
PF08773
(CathepsinC_exc) 		4 LEU A  47
LYS A 371
TYR A   8
LYS A  45
 None
 0.84A 6ce2A-1jqpA:
undetectable		 6ce2A-1jqpA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l5a AMIDE SYNTHASE

(Vibrio cholerae) 		PF00668
(Condensation) 		4 LEU A   2
LEU A 129
GLY A 133
TYR A 161
 None
 0.91A 6ce2A-1l5aA:
undetectable		 6ce2A-1l5aA:
12.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mc2 ACUTOHAEMONLYSIN

(Deinagkistrodon
acutus) 		PF00068
(Phospholip_A2_1) 		6 LEU A1002
LEU A1005
GLY A1033
ARG A1034
LYS A1049
TYR A1052
 IPA  A1136 ( 4.7A)
IPA  A1135 ( 4.2A)
None
None
None
None
 0.78A 6ce2A-1mc2A:
23.1		 6ce2A-1mc2A:
72.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mc2 ACUTOHAEMONLYSIN

(Deinagkistrodon
acutus) 		PF00068
(Phospholip_A2_1) 		6 LEU A1002
LEU A1005
GLY A1033
LYS A1049
TYR A1052
LYS A1069
 IPA  A1136 ( 4.7A)
IPA  A1135 ( 4.2A)
None
None
None
None
 0.64A 6ce2A-1mc2A:
23.1		 6ce2A-1mc2A:
72.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nxz HYPOTHETICAL PROTEIN
HI0303

(Haemophilus
influenzae) 		PF04452
(Methyltrans_RNA) 		4 LEU A 169
LEU A 192
LEU A 217
GLY A 219
 None
 0.91A 6ce2A-1nxzA:
undetectable		 6ce2A-1nxzA:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o2d ALCOHOL
DEHYDROGENASE,
IRON-CONTAINING

(Thermotoga
maritima) 		PF00465
(Fe-ADH) 		4 LEU A  49
LEU A  17
GLY A  95
TYR A 174
 None
None
NAP  A1800 (-3.2A)
None
 0.94A 6ce2A-1o2dA:
undetectable		 6ce2A-1o2dA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pg5 ASPARTATE
CARBAMOYLTRANSFERASE

(Sulfolobus
acidocaldarius) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 LEU A 167
LEU A 168
LEU A 150
TYR A 199
 None
 0.95A 6ce2A-1pg5A:
undetectable		 6ce2A-1pg5A:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q50 GLUCOSE-6-PHOSPHATE
ISOMERASE

(Leishmania
mexicana) 		PF00342
(PGI) 		4 LEU A 368
LEU A 372
LEU A 528
GLY A 460
 None
 0.84A 6ce2A-1q50A:
undetectable		 6ce2A-1q50A:
11.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r8y GLYCINE
N-METHYLTRANSFERASE

(Mus musculus) 		PF13847
(Methyltransf_31) 		4 LEU A  74
LEU A 169
GLY A 168
ARG A 165
 None
 0.94A 6ce2A-1r8yA:
undetectable		 6ce2A-1r8yA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rc2 AQUAPORIN Z

(Escherichia
coli) 		no annotation 4 LEU B 227
LEU B 226
LEU B 146
GLY B 216
 None
 0.90A 6ce2A-1rc2B:
undetectable		 6ce2A-1rc2B:
17.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sjp 60 KDA CHAPERONIN 2

(Mycobacterium
tuberculosis) 		PF00118
(Cpn60_TCP1) 		4 LEU A 234
LEU A 231
LEU A 256
GLY A 253
 None
 0.80A 6ce2A-1sjpA:
2.1		 6ce2A-1sjpA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1smq RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SMALL CHAIN 1

(Saccharomyces
cerevisiae) 		PF00268
(Ribonuc_red_sm) 		4 LEU A 338
LEU A 339
LEU A 232
GLY A 229
 None
 0.88A 6ce2A-1smqA:
undetectable		 6ce2A-1smqA:
14.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1taq TAQ DNA POLYMERASE

(Thermus
aquaticus) 		PF00476
(DNA_pol_A)
PF01367
(5_3_exonuc)
PF02739
(5_3_exonuc_N)
PF09281
(Taq-exonuc) 		4 LEU A 311
LEU A 321
LEU A 351
GLY A 350
 None
 0.93A 6ce2A-1taqA:
undetectable		 6ce2A-1taqA:
8.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1thx THIOREDOXIN

(Nostoc sp. PCC
7120) 		PF00085
(Thioredoxin) 		4 LEU A  99
LEU A 100
GLY A   3
TYR A  49
 None
 0.90A 6ce2A-1thxA:
undetectable		 6ce2A-1thxA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1twd COPPER HOMEOSTASIS
PROTEIN CUTC

(Shigella
flexneri) 		PF03932
(CutC) 		4 LEU A 137
LEU A 134
LEU A 146
GLY A 176
 None
 0.89A 6ce2A-1twdA:
undetectable		 6ce2A-1twdA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vkx PROTEIN (NF-KAPPA B
P50 SUBUNIT)

(Mus musculus) 		PF00554
(RHD_DNA_bind)
PF16179
(RHD_dimer) 		4 LEU B 512
LEU B 397
GLY B 365
ARG B 356
 None
 0.92A 6ce2A-1vkxB:
undetectable		 6ce2A-1vkxB:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdt ELONGATION FACTOR G
HOMOLOG

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		4 LEU A 247
LEU A 246
LEU A 219
GLY A 218
 None
 0.83A 6ce2A-1wdtA:
undetectable		 6ce2A-1wdtA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wqa PHOSPHO-SUGAR MUTASE

(Pyrococcus
horikoshii) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 LEU A  34
LEU A  33
LEU A 113
GLY A 119
 LEU  A  34 ( 0.6A)
LEU  A  33 ( 0.6A)
LEU  A 113 ( 0.6A)
GLY  A 119 ( 0.0A)
 0.77A 6ce2A-1wqaA:
undetectable		 6ce2A-1wqaA:
11.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x3l HYPOTHETICAL PROTEIN
PH0495

(Pyrococcus
horikoshii) 		PF05161
(MOFRL)
PF13660
(DUF4147) 		4 LEU A 146
LEU A 149
LEU A 136
GLY A 132
 None
None
None
SO4  A 505 (-3.3A)
 0.95A 6ce2A-1x3lA:
undetectable		 6ce2A-1x3lA:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xtj PROBABLE
ATP-DEPENDENT RNA
HELICASE P47

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 LEU A 161
LEU A 177
GLY A 174
LYS A 183
 None
 0.87A 6ce2A-1xtjA:
undetectable		 6ce2A-1xtjA:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y1p ALDEHYDE REDUCTASE
II

(Sporidiobolus
salmonicolor) 		PF01370
(Epimerase) 		4 LEU A 113
LEU A 116
LEU A 186
ARG A 270
 None
 0.81A 6ce2A-1y1pA:
undetectable		 6ce2A-1y1pA:
18.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ya5 TELETHONIN

(Homo sapiens) 		PF09470
(Telethonin) 		4 LEU T  28
LEU T  30
GLY T  77
ARG T  76
 None
 0.74A 6ce2A-1ya5T:
undetectable		 6ce2A-1ya5T:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcl PROTEIN TYROSINE
PHOSPHATASE 4A1

(Rattus
norvegicus) 		PF00782
(DSPc) 		4 LEU A 146
LEU A 149
LEU A 108
GLY A 107
 None
None
SO4  A4398 (-4.2A)
SO4  A4398 (-3.4A)
 0.77A 6ce2A-1zclA:
undetectable		 6ce2A-1zclA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zvd SMAD UBIQUITINATION
REGULATORY FACTOR 2

(Homo sapiens) 		PF00632
(HECT) 		5 LEU A 513
LEU A 512
LEU A 624
GLY A 628
ARG A 680
 None
 1.12A 6ce2A-1zvdA:
undetectable		 6ce2A-1zvdA:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ayn UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 14

(Homo sapiens) 		PF00443
(UCH) 		4 LEU A 350
LEU A 419
GLY A 467
ARG A 329
 None
 0.92A 6ce2A-2aynA:
undetectable		 6ce2A-2aynA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c6s ADENOVIRUS 2,12
PENTON BASE CHIMERA

(Human
mastadenovirus
C) 		PF01686
(Adeno_Penton_B) 		4 LEU A 242
LEU A 243
GLY A 260
LYS A 209
 None
 0.90A 6ce2A-2c6sA:
undetectable		 6ce2A-2c6sA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cuy MALONYL COA-[ACYL
CARRIER PROTEIN]
TRANSACYLASE

(Thermus
thermophilus) 		PF00698
(Acyl_transf_1) 		4 LEU A  44
LEU A  41
GLY A 115
ARG A 114
 None
 0.90A 6ce2A-2cuyA:
0.9		 6ce2A-2cuyA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cuy MALONYL COA-[ACYL
CARRIER PROTEIN]
TRANSACYLASE

(Thermus
thermophilus) 		PF00698
(Acyl_transf_1) 		4 LEU A 205
LEU A 209
LEU A  90
GLY A  91
 None
 0.93A 6ce2A-2cuyA:
0.9		 6ce2A-2cuyA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cw7 ENDONUCLEASE
PI-PKOII

(Thermococcus
kodakarensis) 		PF14528
(LAGLIDADG_3)
PF14890
(Intein_splicing) 		4 LEU A 401
LEU A 400
LEU A 282
LYS A 358
 None
 0.93A 6ce2A-2cw7A:
undetectable		 6ce2A-2cw7A:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ejw HOMOSERINE
DEHYDROGENASE

(Thermus
thermophilus) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		4 LEU A 134
LEU A 131
GLY A 207
ARG A 110
 None
 0.91A 6ce2A-2ejwA:
undetectable		 6ce2A-2ejwA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ell ACIDIC LEUCINE-RICH
NUCLEAR
PHOSPHOPROTEIN 32
FAMILY MEMBER B

(Homo sapiens) 		PF14580
(LRR_9) 		4 LEU A 146
LEU A 122
GLY A  86
LYS A 117
 None
 0.70A 6ce2A-2ellA:
undetectable		 6ce2A-2ellA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f3n SH3 AND MULTIPLE
ANKYRIN REPEAT
DOMAINS 3

(Rattus
norvegicus) 		PF00536
(SAM_1) 		4 LEU A  65
LEU A  62
GLY A  11
LYS A   1
 None
 0.95A 6ce2A-2f3nA:
undetectable		 6ce2A-2f3nA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fja ADENYLYLSULFATE
REDUCTASE, SUBUNIT A

(Archaeoglobus
fulgidus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 LEU A 343
LEU A 278
GLY A 142
ARG A  85
 None
 0.81A 6ce2A-2fjaA:
1.4		 6ce2A-2fjaA:
10.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g2o MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Escherichia
coli) 		PF00698
(Acyl_transf_1) 		4 LEU A  47
LEU A  44
GLY A 118
ARG A 117
 None
None
None
SO4  A1001 (-2.9A)
 0.85A 6ce2A-2g2oA:
undetectable		 6ce2A-2g2oA:
17.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2q BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Trypanosoma
cruzi) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 LEU A 112
LEU A 109
GLY A  93
LYS A 117
 None
 0.80A 6ce2A-2h2qA:
undetectable		 6ce2A-2h2qA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6e D-ARABINOSE
1-DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 LEU A 137
LEU A 140
GLY A  39
ARG A 339
 None
 0.82A 6ce2A-2h6eA:
undetectable		 6ce2A-2h6eA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id5 LEUCINE RICH REPEAT
NEURONAL 6A

(Homo sapiens) 		PF07679
(I-set)
PF13306
(LRR_5)
PF13855
(LRR_8) 		4 LEU A 154
LEU A 130
LEU A 159
GLY A 136
 None
 0.87A 6ce2A-2id5A:
undetectable		 6ce2A-2id5A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ija ARYLAMINE
N-ACETYLTRANSFERASE
1

(Homo sapiens) 		PF00797
(Acetyltransf_2) 		4 LEU A 152
LEU A 137
GLY A  90
ARG A 197
 None
 0.93A 6ce2A-2ijaA:
undetectable		 6ce2A-2ijaA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ivf ETHYLBENZENE
DEHYDROGENASE
ALPHA-SUBUNIT

(Aromatoleum
aromaticum) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 LEU A 506
LEU A 491
GLY A 201
TYR A 208
 None
 0.94A 6ce2A-2ivfA:
undetectable		 6ce2A-2ivfA:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		4 LEU A 791
LEU A 554
GLY A 594
TYR A 758
 None
 0.95A 6ce2A-2jgdA:
1.7		 6ce2A-2jgdA:
7.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kso PHOSPHATIDYLINOSITOL
-3,4,5-TRISPHOSPHATE
5-PHOSPHATASE 2

(Homo sapiens) 		PF00536
(SAM_1) 		4 LEU B  56
LEU B  53
LEU B  38
GLY B  37
 None
 0.76A 6ce2A-2ksoB:
undetectable		 6ce2A-2ksoB:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lsu TPR
REPEAT-CONTAINING
PROTEIN ASSOCIATED
WITH HSP90

(Saccharomyces
cerevisiae) 		PF14559
(TPR_19) 		4 LEU A  51
LEU A  48
LEU A  14
GLY A  11
 None
 0.93A 6ce2A-2lsuA:
undetectable		 6ce2A-2lsuA:
25.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mzc GLUTAREDOXIN

(Brucella
melitensis) 		PF00462
(Glutaredoxin) 		4 LEU A  26
LEU A  25
GLY A  68
LYS A  23
 None
 0.95A 6ce2A-2mzcA:
undetectable		 6ce2A-2mzcA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2na0 GUANYLYL
CYCLASE-ACTIVATING
PROTEIN 1

(Bos taurus) 		PF00036
(EF-hand_1)
PF13499
(EF-hand_7) 		4 LEU A 166
LEU A 170
LEU A 113
ARG A 117
 None
 0.92A 6ce2A-2na0A:
undetectable		 6ce2A-2na0A:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq5 5-METHYLTETRAHYDROPT
EROYLTRIGLUTAMATE--H
OMOCYSTEINE
METHYLTRANSFERASE

(Streptococcus
mutans) 		PF01717
(Meth_synt_2)
PF08267
(Meth_synt_1) 		4 LEU A 300
LEU A 301
LEU A 256
GLY A 255
 None
 0.89A 6ce2A-2nq5A:
undetectable		 6ce2A-2nq5A:
8.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvn HYPOTHETICAL PROTEIN

(Synechococcus
elongatus) 		PF08848
(DUF1818) 		4 LEU A  93
LEU A  76
LEU A  25
GLY A  14
 None
 0.59A 6ce2A-2nvnA:
undetectable		 6ce2A-2nvnA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o4c ERYTHRONATE-4-PHOSPH
ATE DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C)
PF11890
(DUF3410) 		4 LEU A 103
LEU A 104
GLY A 137
ARG A 370
 None
 0.95A 6ce2A-2o4cA:
undetectable		 6ce2A-2o4cA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ojq PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN

(Homo sapiens) 		PF13949
(ALIX_LYPXL_bnd) 		4 LEU A 401
LEU A 399
LEU A 625
GLY A 624
 None
 0.95A 6ce2A-2ojqA:
undetectable		 6ce2A-2ojqA:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjc DIADENOSINE
TETRAPHOSPHATASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00149
(Metallophos) 		4 LEU A 111
LEU A 108
LEU A  56
GLY A  54
 None
 0.82A 6ce2A-2qjcA:
undetectable		 6ce2A-2qjcA:
18.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qm8 GTPASE/ATPASE

(Methylobacterium
extorquens) 		PF03308
(ArgK) 		4 LEU A  15
LEU A  23
GLY A  53
ARG A  57
 None
 0.93A 6ce2A-2qm8A:
undetectable		 6ce2A-2qm8A:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rb9 HYPE PROTEIN

(Escherichia
coli) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 LEU A 196
LEU A 192
LEU A 264
GLY A 263
 None
 0.90A 6ce2A-2rb9A:
undetectable		 6ce2A-2rb9A:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rex PLEXIN-B1

(Homo sapiens) 		PF08337
(Plexin_cytopl) 		4 LEU A1785
LEU A1788
GLY A1758
LYS A1781
 None
None
None
UNX  A  11 (-3.5A)
 0.94A 6ce2A-2rexA:
undetectable		 6ce2A-2rexA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v8p 4-DIPHOSPHOCYTIDYL-2
-C-METHYL-D-ERYTHRIT
OL KINASE

(Aquifex
aeolicus) 		PF00288
(GHMP_kinases_N) 		4 LEU A 123
LEU A 120
LEU A  61
GLY A  96
 None
None
ADP  A1270 (-3.9A)
ADP  A1270 (-3.4A)
 0.93A 6ce2A-2v8pA:
undetectable		 6ce2A-2v8pA:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9k UNCHARACTERIZED
PROTEIN FLJ32312

(Homo sapiens) 		no annotation 4 LEU A 350
GLY A 351
ARG A 390
TYR A 294
 None
 0.95A 6ce2A-2v9kA:
undetectable		 6ce2A-2v9kA:
12.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vi7 ACETYLTRANSFERASE
PA1377

(Pseudomonas
aeruginosa) 		PF00583
(Acetyltransf_1) 		4 LEU A  21
LEU A  24
LEU A  61
ARG A 105
 None
 0.94A 6ce2A-2vi7A:
undetectable		 6ce2A-2vi7A:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wtk SERINE/THREONINE-PRO
TEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU C 290
LEU C 252
GLY C 251
ARG C 147
 None
 0.93A 6ce2A-2wtkC:
undetectable		 6ce2A-2wtkC:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x8u SERINE
PALMITOYLTRANSFERASE

(Sphingomonas
wittichii) 		PF00155
(Aminotran_1_2) 		4 LEU A 347
LEU A 352
GLY A 312
ARG A 308
 None
 0.94A 6ce2A-2x8uA:
undetectable		 6ce2A-2x8uA:
12.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xes PROTEIN PAT1 HOMOLOG
1

(Homo sapiens) 		PF09770
(PAT1) 		4 LEU A 689
LEU A 686
LEU A 726
LYS A 762
 None
 0.85A 6ce2A-2xesA:
undetectable		 6ce2A-2xesA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xio PUTATIVE
DEOXYRIBONUCLEASE
TATDN1

(Homo sapiens) 		PF01026
(TatD_DNase) 		4 LEU A 209
LEU A 206
LEU A 267
ARG A 239
 None
 0.93A 6ce2A-2xioA:
undetectable		 6ce2A-2xioA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywd GLUTAMINE
AMIDOTRANSFERASE
SUBUNIT PDXT

(Thermus
thermophilus) 		PF01174
(SNO) 		4 LEU A  43
LEU A  37
GLY A  54
ARG A  58
 None
 0.87A 6ce2A-2ywdA:
undetectable		 6ce2A-2ywdA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxz THIAMIN-MONOPHOSPHAT
E KINASE

(Thermus
thermophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 LEU A 298
LEU A 303
GLY A 162
TYR A 254
 None
 0.82A 6ce2A-2yxzA:
undetectable		 6ce2A-2yxzA:
15.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6g B-CATENIN

(Danio rerio) 		PF00514
(Arm) 		4 LEU A 404
LEU A 369
GLY A 360
ARG A 328
 None
 0.91A 6ce2A-2z6gA:
undetectable		 6ce2A-2z6gA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8e GALACTO-N-BIOSE/LACT
O-N-BIOSE I
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Bifidobacterium
longum) 		PF01547
(SBP_bac_1) 		4 LEU A 344
LEU A 151
GLY A 150
TYR A  46
 None
 0.95A 6ce2A-2z8eA:
undetectable		 6ce2A-2z8eA:
14.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zpb NITRILE HYDRATASE
SUBUNIT ALPHA
NITRILE HYDRATASE
SUBUNIT BETA

(Rhodococcus
erythropolis) 		PF02211
(NHase_beta)
PF02979
(NHase_alpha) 		4 LEU B  95
LEU B  98
LEU A  34
GLY A  33
 None
 0.93A 6ce2A-2zpbB:
undetectable		 6ce2A-2zpbB:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zuk ALPHA-AMINO-EPSILON-
CAPROLACTAM RACEMASE

(Achromobacter
obae) 		PF00202
(Aminotran_3) 		4 LEU A  88
LEU A 310
LEU A 273
GLY A 272
 None
 0.90A 6ce2A-2zukA:
undetectable		 6ce2A-2zukA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3amj ZINC PEPTIDASE
ACTIVE SUBUNIT

(Sphingomonas
sp. A1) 		no annotation 4 LEU C 407
GLY C 406
ARG C  62
TYR C 114
 None
 0.88A 6ce2A-3amjC:
undetectable		 6ce2A-3amjC:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3apq DNAJ HOMOLOG
SUBFAMILY C MEMBER
10

(Mus musculus) 		PF00085
(Thioredoxin)
PF00226
(DnaJ) 		4 LEU A  39
LEU A  40
LEU A  78
GLY A 110
 None
 0.94A 6ce2A-3apqA:
1.3		 6ce2A-3apqA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)

(Thermus
thermophilus) 		PF14520
(HHH_5)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb) 		4 LEU A 306
LEU A 324
LEU A 278
GLY A 277
 None
 0.95A 6ce2A-3auoA:
undetectable		 6ce2A-3auoA:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw8 PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Thermus
thermophilus) 		PF02222
(ATP-grasp) 		4 LEU A  14
LEU A 289
GLY A 288
ARG A 189
 None
 0.92A 6ce2A-3aw8A:
undetectable		 6ce2A-3aw8A:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b46 AMINOTRANSFERASE
BNA3

(Saccharomyces
cerevisiae) 		PF00155
(Aminotran_1_2) 		4 LEU A 101
LEU A 104
GLY A 270
LYS A 272
 None
None
LLP  A 271 ( 2.4A)
LLP  A 271 ( 3.1A)
 0.89A 6ce2A-3b46A:
undetectable		 6ce2A-3b46A:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5i S-ADENOSYL-L-METHION
INE:SALICYLIC ACID
CARBOXYL
METHYLTRANSFERASE-LI
KE PROTEIN

(Arabidopsis
thaliana) 		PF03492
(Methyltransf_7) 		4 LEU A 160
GLY A 139
ARG A 143
TYR A 142
 None
None
None
SAH  A 401 (-4.2A)
 0.84A 6ce2A-3b5iA:
undetectable		 6ce2A-3b5iA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b89 16S RRNA METHYLASE

(Escherichia
coli) 		PF07091
(FmrO) 		4 LEU A  91
LEU A  94
LEU A 114
GLY A 113
 None
None
None
5GP  A 500 ( 4.5A)
 0.90A 6ce2A-3b89A:
undetectable		 6ce2A-3b89A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4n UNCHARACTERIZED
PROTEIN DR_0571

(Deinococcus
radiodurans) 		PF01266
(DAO) 		4 LEU A 317
LEU A 318
LEU A 260
GLY A 335
 None
 0.82A 6ce2A-3c4nA:
0.7		 6ce2A-3c4nA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cwr TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY

(Rhodospirillum
rubrum) 		PF00440
(TetR_N) 		4 LEU A 109
LEU A 113
LEU A  63
GLY A  59
 None
 0.86A 6ce2A-3cwrA:
undetectable		 6ce2A-3cwrA:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cyv UROPORPHYRINOGEN
DECARBOXYLASE

(Shigella
flexneri) 		PF01208
(URO-D) 		4 LEU A  61
LEU A  64
LEU A  74
GLY A 143
 None
 0.83A 6ce2A-3cyvA:
undetectable		 6ce2A-3cyvA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3doa FIBRINOGEN BINDING
PROTEIN

(Staphylococcus
aureus) 		PF05833
(FbpA) 		4 LEU A 273
LEU A   6
GLY A   5
ARG A  97
 None
 0.95A 6ce2A-3doaA:
undetectable		 6ce2A-3doaA:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3drn PEROXIREDOXIN,
BACTERIOFERRITIN
COMIGRATORY PROTEIN
HOMOLOG

(Sulfolobus
solfataricus) 		PF00578
(AhpC-TSA) 		4 LEU A  10
LEU A  23
GLY A   5
TYR A 102
 None
 0.83A 6ce2A-3drnA:
undetectable		 6ce2A-3drnA:
22.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dsg TYPE IV FIMBRIAE
ASSEMBLY PROTEIN

(Xanthomonas
campestris) 		PF07238
(PilZ) 		4 LEU A  15
LEU A  54
GLY A  32
ARG A  97
 None
 0.95A 6ce2A-3dsgA:
undetectable		 6ce2A-3dsgA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ekg MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Azotobacter
vinelandii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 LEU A 384
LEU A 359
LEU A  61
TYR A 325
 None
 0.94A 6ce2A-3ekgA:
undetectable		 6ce2A-3ekgA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fai BETA-LACTAMASE

(Aeromonas
hydrophila) 		PF00753
(Lactamase_B) 		4 LEU A 217
LEU A 254
GLY A 193
ARG A 248
 None
 0.95A 6ce2A-3faiA:
undetectable		 6ce2A-3faiA:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpz THIAZOLE
BIOSYNTHETIC ENZYME

(Saccharomyces
cerevisiae) 		PF01946
(Thi4) 		4 LEU A 129
LEU A 126
LEU A  78
GLY A  74
 None
None
None
AHZ  A1100 (-3.6A)
 0.92A 6ce2A-3fpzA:
undetectable		 6ce2A-3fpzA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5a FMN
ADENYLYLTRANSFERASE

([Candida]
glabrata) 		PF01507
(PAPS_reduct) 		4 LEU A 130
LEU A 132
LEU A  70
GLY A 163
 None
None
None
APC  A 305 (-3.2A)
 0.90A 6ce2A-3g5aA:
undetectable		 6ce2A-3g5aA:
16.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hl0 MALEYLACETATE
REDUCTASE

(Agrobacterium
fabrum) 		PF00465
(Fe-ADH) 		4 LEU A 179
LEU A 279
LEU A 225
GLY A 222
 None
 0.90A 6ce2A-3hl0A:
1.1		 6ce2A-3hl0A:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i16 ALUMINUM RESISTANCE
PROTEIN

(Clostridium
novyi) 		PF06838
(Met_gamma_lyase) 		4 LEU A 107
LEU A 103
GLY A 122
TYR A 125
 None
None
None
TLA  A 427 (-4.5A)
 0.95A 6ce2A-3i16A:
1.8		 6ce2A-3i16A:
16.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bgc GRANULOCYTE
COLONY-STIMULATING
FACTOR

(Bos taurus) 		PF16647
(GCSF) 		5 LEU A 172
LEU A 169
GLY A  74
GLY A 126
PRO A  11
 None
 1.05A 6ce2B-1bgcA:
undetectable		 6ce2B-1bgcA:
20.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bpq PHOSPHOLIPASE A2

(Bos taurus) 		PF00068
(Phospholip_A2_1) 		5 LEU A   2
GLY A  30
GLY A  32
TYR A  52
PRO A  68
 None
CA  A 124 (-4.2A)
CA  A 124 (-4.2A)
None
None
 0.93A 6ce2B-1bpqA:
17.6		 6ce2B-1bpqA:
37.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bun BETA2-BUNGAROTOXIN

(Bungarus
multicinctus) 		PF00068
(Phospholip_A2_1) 		6 GLY A  30
GLY A  32
TYR A  52
ASN A  62
PRO A  63
LYS A  64
 NA  A 121 (-4.4A)
NA  A 121 (-3.8A)
None
None
None
None
 1.00A 6ce2B-1bunA:
16.4		 6ce2B-1bunA:
37.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1bun BETA2-BUNGAROTOXIN

(Bungarus
multicinctus) 		PF00068
(Phospholip_A2_1) 		6 LEU A   2
GLY A  32
TYR A  52
ASN A  62
PRO A  63
LYS A  64
 None
NA  A 121 (-3.8A)
None
None
None
None
 0.93A 6ce2B-1bunA:
16.4		 6ce2B-1bunA:
37.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cvr GINGIPAIN R

(Porphyromonas
gingivalis) 		PF01364
(Peptidase_C25)
PF03785
(Peptidase_C25_C) 		5 LEU A 345
GLY A  35
ARG A  11
TYR A  72
PRO A 342
 None
 1.13A 6ce2B-1cvrA:
undetectable		 6ce2B-1cvrA:
13.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1dpy PHOSPHOLIPASE A2

(Bungarus
caeruleus) 		PF00068
(Phospholip_A2_1) 		5 GLY A  30
GLY A  32
TYR A  52
ASN A  62
PRO A  63
 NA  A 150 (-4.5A)
NA  A 150 (-4.5A)
None
None
None
 1.03A 6ce2B-1dpyA:
16.8		 6ce2B-1dpyA:
36.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1esc ESTERASE

(Streptomyces
scabiei) 		PF13472
(Lipase_GDSL_2) 		5 LEU A 220
LEU A 217
GLY A 263
ARG A 260
PRO A 191
 None
 1.06A 6ce2B-1escA:
undetectable		 6ce2B-1escA:
18.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1g0z PHOSPHOLIPASE A2

(Bungarus
caeruleus) 		PF00068
(Phospholip_A2_1) 		5 GLY A  30
GLY A  32
TYR A  52
ASN A  62
PRO A  63
 None
 0.95A 6ce2B-1g0zA:
16.5		 6ce2B-1g0zA:
34.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gju MALTODEXTRIN
GLYCOSYLTRANSFERASE

(Thermotoga
maritima) 		PF00128
(Alpha-amylase)
PF09083
(DUF1923) 		5 LEU A 433
LEU A 461
GLY A 381
ARG A 197
PRO A 459
 None
 1.14A 6ce2B-1gjuA:
undetectable		 6ce2B-1gjuA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lkf LEUKOCIDIN F SUBUNIT

(Staphylococcus
aureus) 		PF07968
(Leukocidin) 		5 LEU A  36
GLY A   2
TYR A 245
ASN A 222
PRO A 223
 None
 1.06A 6ce2B-1lkfA:
undetectable		 6ce2B-1lkfA:
14.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mc2 ACUTOHAEMONLYSIN

(Deinagkistrodon
acutus) 		PF00068
(Phospholip_A2_1) 		6 LEU A1002
GLY A1023
GLY A1030
GLY A1033
ARG A1034
LYS A1049
 IPA  A1136 ( 4.7A)
IPA  A1135 ( 4.1A)
IPA  A1135 ( 4.4A)
None
None
None
 1.27A 6ce2B-1mc2A:
22.7		 6ce2B-1mc2A:
72.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mc2 ACUTOHAEMONLYSIN

(Deinagkistrodon
acutus) 		PF00068
(Phospholip_A2_1) 		5 LEU A1002
GLY A1023
GLY A1030
GLY A1033
LYS A1049
 IPA  A1136 ( 4.7A)
IPA  A1135 ( 4.1A)
IPA  A1135 ( 4.4A)
None
None
 0.94A 6ce2B-1mc2A:
22.7		 6ce2B-1mc2A:
72.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mc2 ACUTOHAEMONLYSIN

(Deinagkistrodon
acutus) 		PF00068
(Phospholip_A2_1) 		6 LEU A1002
LEU A1005
GLY A1023
GLY A1030
GLY A1033
TYR A1052
 IPA  A1136 ( 4.7A)
IPA  A1135 ( 4.2A)
IPA  A1135 ( 4.1A)
IPA  A1135 ( 4.4A)
None
None
 0.88A 6ce2B-1mc2A:
22.7		 6ce2B-1mc2A:
72.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mc2 ACUTOHAEMONLYSIN

(Deinagkistrodon
acutus) 		PF00068
(Phospholip_A2_1) 		6 LEU A1005
GLY A1023
GLY A1030
GLY A1033
ARG A1034
TYR A1052
 IPA  A1135 ( 4.2A)
IPA  A1135 ( 4.1A)
IPA  A1135 ( 4.4A)
None
None
None
 0.54A 6ce2B-1mc2A:
22.7		 6ce2B-1mc2A:
72.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1n28 PHOSPHOLIPASE A2,
MEMBRANE ASSOCIATED

(Homo sapiens) 		no annotation 5 GLY B  22
GLY B  29
GLY B  31
TYR B  51
LYS B  62
 None
CA  B 125 (-4.4A)
CA  B 125 (-4.2A)
None
None
 0.83A 6ce2B-1n28B:
20.2		 6ce2B-1n28B:
47.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oa4 ENDO-BETA-1,4-GLUCAN
ASE

(Streptomyces
sp. 11AG8) 		PF01670
(Glyco_hydro_12) 		5 LEU A 211
GLY A  97
GLY A 207
GLY A  46
ASN A  21
 None
 1.08A 6ce2B-1oa4A:
undetectable		 6ce2B-1oa4A:
18.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1oz6 PHOSPHOLIPASE A2

(Echis carinatus) 		PF00068
(Phospholip_A2_1) 		5 GLY A  23
GLY A  32
TYR A  52
PRO A  68
LYS A  69
 None
CA  A 134 (-4.3A)
None
None
None
 0.86A 6ce2B-1oz6A:
19.6		 6ce2B-1oz6A:
48.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p43 ENOLASE 1

(Saccharomyces
cerevisiae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 LEU A 406
LEU A 409
GLY A 212
GLY A 376
ARG A 374
 None
None
None
None
2PG  A 441 (-3.9A)
 1.00A 6ce2B-1p43A:
undetectable		 6ce2B-1p43A:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pgp 6-PHOSPHOGLUCONATE
DEHYDROGENASE

(Ovis aries) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		5 LEU A 352
LEU A 341
GLY A 177
GLY A 179
GLY A 126
 None
 1.13A 6ce2B-1pgpA:
undetectable		 6ce2B-1pgpA:
16.22
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1po8 PHOSPHOLIPASE A2

(Bungarus
caeruleus) 		PF00068
(Phospholip_A2_1) 		5 LEU A   5
GLY A  30
GLY A  32
TYR A  52
PRO A  63
 None
SHV  A 122 ( 3.7A)
NA  A 121 (-3.3A)
None
None
 0.87A 6ce2B-1po8A:
16.7		 6ce2B-1po8A:
36.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pxt PEROXISOMAL
3-KETOACYL-COA
THIOLASE

(Saccharomyces
cerevisiae) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 LEU A 148
GLY A  91
GLY A 151
GLY A 279
ASN A  68
 None
 1.13A 6ce2B-1pxtA:
undetectable		 6ce2B-1pxtA:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ru4 PECTATE LYASE

(Dickeya
chrysanthemi) 		PF13229
(Beta_helix) 		5 LEU A 274
LEU A 238
GLY A 271
GLY A 269
ASN A 302
 None
 1.13A 6ce2B-1ru4A:
undetectable		 6ce2B-1ru4A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sfe ADA
O6-METHYLGUANINE-DNA
METHYLTRANSFERASE

(Escherichia
coli) 		PF01035
(DNA_binding_1)
PF02870
(Methyltransf_1N) 		5 LEU A  27
LEU A  51
GLY A  34
ARG A  33
ASN A 138
 None
 1.01A 6ce2B-1sfeA:
undetectable		 6ce2B-1sfeA:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpe PHOSPHOGLYCERATE
KINASE

(Thermotoga
maritima) 		PF00162
(PGK) 		5 LEU A 178
LEU A 383
GLY A 352
TYR A 189
PRO A 185
 None
 1.12A 6ce2B-1vpeA:
undetectable		 6ce2B-1vpeA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w85 PYRUVATE
DEHYDROGENASE E1
COMPONENT, ALPHA
SUBUNIT
PYRUVATE
DEHYDROGENASE E1
COMPONENT, BETA
SUBUNIT

(Geobacillus
stearothermophilus) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		6 LEU A  99
LEU A 138
GLY A 153
GLY B  68
GLY B  73
TYR B 108
 None
 1.40A 6ce2B-1w85A:
undetectable		 6ce2B-1w85A:
14.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zl7 HYPOTENSIVE
PHOSPHOLIPASE A2

(Bothrops
jararacussu) 		PF00068
(Phospholip_A2_1) 		5 GLY A  29
GLY A  31
TYR A  51
ASN A  58
PRO A  59
 None
CA  A1001 (-3.9A)
None
None
None
 0.81A 6ce2B-1zl7A:
18.5		 6ce2B-1zl7A:
51.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1zl7 HYPOTENSIVE
PHOSPHOLIPASE A2

(Bothrops
jararacussu) 		PF00068
(Phospholip_A2_1) 		5 GLY A  29
GLY A  31
TYR A  51
PRO A  59
LYS A  60
 None
CA  A1001 (-3.9A)
None
None
None
 1.12A 6ce2B-1zl7A:
18.5		 6ce2B-1zl7A:
51.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b0o UPLC1

(Homo sapiens) 		PF01412
(ArfGap)
PF12796
(Ank_2) 		5 LEU E 564
LEU E 561
GLY E 457
GLY E 498
GLY E 437
 None
 1.10A 6ce2B-2b0oE:
undetectable		 6ce2B-2b0oE:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bmy RIPENING-ASSOCIATED
PROTEIN

(Musa acuminata) 		PF01419
(Jacalin) 		5 LEU A  92
LEU A  89
GLY A  39
GLY A  59
ASN A 106
 None
 1.05A 6ce2B-2bmyA:
undetectable		 6ce2B-2bmyA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bvg 6-HYDROXY-D-NICOTINE
OXIDASE

(Paenarthrobacter
nicotinovorans) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 LEU A 435
GLY A 187
GLY A 189
GLY A 193
PRO A 456
 None
 1.08A 6ce2B-2bvgA:
undetectable		 6ce2B-2bvgA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c1l RESTRICTION
ENDONUCLEASE

(Bacillus firmus) 		PF13091
(PLDc_2) 		5 LEU A  19
GLY A  49
GLY A 128
ASN A   9
PRO A   8
 None
 1.05A 6ce2B-2c1lA:
undetectable		 6ce2B-2c1lA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c2n MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Homo sapiens) 		PF00698
(Acyl_transf_1) 		5 LEU A 249
LEU A 280
GLY A 135
GLY A 128
TYR A 270
 None
 1.07A 6ce2B-2c2nA:
undetectable		 6ce2B-2c2nA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI

(Saccharopolyspora
erythraea) 		PF08659
(KR) 		5 LEU A1549
LEU A1553
GLY A1594
GLY A1596
GLY A1609
 None
 1.10A 6ce2B-2fr1A:
undetectable		 6ce2B-2fr1A:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipc PREPROTEIN
TRANSLOCASE SECA
SUBUNIT

(Thermus
thermophilus) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		5 LEU A 585
GLY A 686
GLY A 683
GLY A 680
ARG A 679
 None
 1.14A 6ce2B-2ipcA:
undetectable		 6ce2B-2ipcA:
7.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isn NYSGXRC-8828Z,
PHOSPHATASE

(Toxoplasma
gondii) 		PF00481
(PP2C) 		5 LEU A 231
LEU A 233
GLY A 238
GLY A 102
GLY A  54
 None
 1.09A 6ce2B-2isnA:
undetectable		 6ce2B-2isnA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iut DNA TRANSLOCASE FTSK

(Pseudomonas
aeruginosa) 		PF01580
(FtsK_SpoIIIE) 		5 GLY A 693
GLY A 444
GLY A 449
ARG A 450
PRO A 430
 AGS  A1723 (-4.0A)
None
None
None
None
 1.09A 6ce2B-2iutA:
undetectable		 6ce2B-2iutA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3i HYPOTHETICAL PROTEIN

(Chromobacterium
violaceum) 		PF06032
(DUF917) 		5 LEU A 255
LEU A 251
GLY A 233
GLY A  16
GLY A 110
 None
 0.95A 6ce2B-2o3iA:
undetectable		 6ce2B-2o3iA:
14.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2osn PHOSPHOLIPASE A2
ISOFORM 3

(Bungarus
caeruleus) 		PF00068
(Phospholip_A2_1) 		5 GLY A  30
GLY A  32
TYR A  52
ASN A  62
PRO A  63
 None
CL  A 121 ( 4.4A)
None
None
None
 0.96A 6ce2B-2osnA:
16.6		 6ce2B-2osnA:
33.60
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ph4 ZHAOERMIATOXIN

(Protobothrops
mangshanensis) 		PF00068
(Phospholip_A2_1) 		6 LEU A   2
LEU A   5
GLY A  30
GLY A  32
PRO A  68
LYS A  69
 None
PEG  A 401 ( 4.3A)
PEG  A 401 ( 4.5A)
SO4  A 301 (-3.5A)
None
None
 1.22A 6ce2B-2ph4A:
21.2		 6ce2B-2ph4A:
72.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ph4 ZHAOERMIATOXIN

(Protobothrops
mangshanensis) 		PF00068
(Phospholip_A2_1) 		6 LEU A   2
LEU A   5
GLY A  30
TYR A  52
PRO A  68
LYS A  69
 None
PEG  A 401 ( 4.3A)
PEG  A 401 ( 4.5A)
None
None
None
 0.81A 6ce2B-2ph4A:
21.2		 6ce2B-2ph4A:
72.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vfv XYLITOL OXIDASE

(Streptomyces
coelicolor) 		PF01565
(FAD_binding_4)
PF04030
(ALO) 		6 LEU A  60
LEU A  20
GLY A  45
GLY A  43
GLY A  84
PRO A  23
 None
None
SFD  A1418 (-3.4A)
SFD  A1418 (-3.0A)
None
None
 1.36A 6ce2B-2vfvA:
undetectable		 6ce2B-2vfvA:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x4g NUCLEOSIDE-DIPHOSPHA
TE-SUGAR EPIMERASE

(Pseudomonas
aeruginosa) 		PF01370
(Epimerase) 		5 LEU A  52
LEU A  41
GLY A  22
GLY A  25
GLY A 222
 None
 1.02A 6ce2B-2x4gA:
undetectable		 6ce2B-2x4gA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdr BETAINE ALDEHYDE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00171
(Aldedh) 		5 LEU A 167
GLY A  56
GLY A 200
GLY A  13
TYR A 192
 None
 1.11A 6ce2B-2xdrA:
undetectable		 6ce2B-2xdrA:
14.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z8z LIPASE

(Pseudomonas sp.
MIS38) 		PF00353
(HemolysinCabind) 		5 LEU A 568
GLY A 443
GLY A 403
GLY A 383
TYR A 388
 None
None
CA  A 621 ( 4.7A)
CA  A 621 (-4.4A)
None
 1.12A 6ce2B-2z8zA:
undetectable		 6ce2B-2z8zA:
10.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7r ESTERASE

(Staphylococcus
aureus) 		PF07859
(Abhydrolase_3) 		5 LEU A  99
LEU A  98
GLY A 150
GLY A  85
PRO A  93
 None
DMS  A1417 (-3.9A)
None
None
DMS  A1410 (-4.7A)
 1.07A 6ce2B-3d7rA:
undetectable		 6ce2B-3d7rA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e96 DIHYDRODIPICOLINATE
SYNTHASE

(Bacillus
clausii) 		PF00701
(DHDPS) 		5 LEU A 227
LEU A 230
GLY A 210
GLY A 194
LYS A 222
 None
 1.08A 6ce2B-3e96A:
undetectable		 6ce2B-3e96A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N) 		5 GLY A1025
GLY A 568
GLY A 572
ARG A 535
TYR A 325
 None
 0.95A 6ce2B-3egwA:
undetectable		 6ce2B-3egwA:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eyk HEMAGGLUTININ HA1
CHAIN

(Influenza A
virus) 		PF00509
(Hemagglutinin) 		5 LEU A 181
GLY A  72
GLY A  69
ARG A 109
LYS A 261
 None
 1.13A 6ce2B-3eykA:
undetectable		 6ce2B-3eykA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gq9 PRENECK APPENDAGE
PROTEIN

(Bacillus virus
phi29) 		PF11962
(Peptidase_G2)
PF12708
(Pectate_lyase_3) 		6 LEU A 192
LEU A 155
GLY A 146
ARG A 145
ASN A 187
PRO A 150
 None
 1.47A 6ce2B-3gq9A:
undetectable		 6ce2B-3gq9A:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hn0 NITRATE TRANSPORT
PROTEIN

(Parabacteroides
distasonis) 		no annotation 5 LEU A 177
LEU A 183
GLY A 169
GLY A 152
LYS A 179
 None
 1.06A 6ce2B-3hn0A:
undetectable		 6ce2B-3hn0A:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hvn HEMOLYSIN

(Streptococcus
suis) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		5 LEU A 351
LEU A 158
GLY A 271
GLY A 354
GLY A 325
 None
 1.11A 6ce2B-3hvnA:
undetectable		 6ce2B-3hvnA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg9 CURK

(Lyngbya
majuscula) 		PF14765
(PS-DH) 		5 LEU A 993
LEU A 985
GLY A1008
ARG A1036
PRO A1041
 None
 1.07A 6ce2B-3kg9A:
undetectable		 6ce2B-3kg9A:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khj INOSINE-5-MONOPHOSPH
ATE DEHYDROGENASE

(Cryptosporidium
parvum) 		PF00478
(IMPDH) 		5 LEU A  16
GLY A 259
GLY A 351
ASN A  20
PRO A  19
 None
 1.05A 6ce2B-3khjA:
undetectable		 6ce2B-3khjA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kjx TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Ruegeria
pomeroyi) 		PF00356
(LacI)
PF00532
(Peripla_BP_1) 		5 LEU A 277
LEU A 249
GLY A 273
GLY A 182
ARG A 184
 None
 1.05A 6ce2B-3kjxA:
undetectable		 6ce2B-3kjxA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pco PHENYLALANYL-TRNA
SYNTHETASE, ALPHA
SUBUNIT
PHENYLALANYL-TRNA
SYNTHETASE, BETA
CHAIN

(Escherichia
coli) 		PF01409
(tRNA-synt_2d)
PF01588
(tRNA_bind)
PF02912
(Phe_tRNA-synt_N)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		5 LEU A 227
LEU A 223
GLY A 296
GLY A 271
ASN B 472
 None
None
PHE  A 980 (-3.6A)
PHE  A 980 (-4.0A)
None
 0.89A 6ce2B-3pcoA:
undetectable		 6ce2B-3pcoA:
16.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q8x ZETA-TOXIN

(Streptococcus
pyogenes) 		PF06414
(Zeta_toxin) 		5 LEU B 203
LEU B 226
GLY B  39
GLY B  40
GLY B  43
 None
None
None
None
SO4  B 602 (-3.3A)
 1.05A 6ce2B-3q8xB:
undetectable		 6ce2B-3q8xB:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qk7 TRANSCRIPTIONAL
REGULATORS

(Yersinia pestis) 		PF00532
(Peripla_BP_1) 		5 LEU A  45
LEU A  11
GLY A  33
GLY A  37
ARG A  39
 None
 1.09A 6ce2B-3qk7A:
undetectable		 6ce2B-3qk7A:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qpb URIDINE
PHOSPHORYLASE

(Streptococcus
pyogenes) 		PF01048
(PNP_UDP_1) 		5 LEU A 202
GLY A  73
GLY A  74
GLY A 121
TYR A 126
 None
 1.10A 6ce2B-3qpbA:
undetectable		 6ce2B-3qpbA:
18.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r8e HYPOTHETICAL SUGAR
KINASE

(Cytophaga
hutchinsonii) 		PF00480
(ROK) 		5 LEU A 247
LEU A 131
GLY A 226
GLY A 230
ASN A 244
 None
 1.04A 6ce2B-3r8eA:
undetectable		 6ce2B-3r8eA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rj8 CARBOHYDRATE OXIDASE

(Microdochium
nivale) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 LEU A 450
GLY A 189
GLY A 191
GLY A 195
PRO A 471
 None
 1.04A 6ce2B-3rj8A:
undetectable		 6ce2B-3rj8A:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tl2 MALATE DEHYDROGENASE

(Bacillus
anthracis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 LEU A 268
LEU A 270
GLY A 261
GLY A 264
LYS A 294
 None
 1.14A 6ce2B-3tl2A:
undetectable		 6ce2B-3tl2A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugv ENOLASE

(alpha
proteobacterium
BAL199) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 124
LEU A 352
GLY A 310
TYR A 337
PRO A 347
 None
 1.10A 6ce2B-3ugvA:
undetectable		 6ce2B-3ugvA:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vov GLUCOKINASE

(Thermus
thermophilus) 		PF00480
(ROK) 		5 LEU A 243
GLY A 138
GLY A 137
GLY A 135
ASN A 250
 None
 1.14A 6ce2B-3vovA:
undetectable		 6ce2B-3vovA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bkw ZINC FINGER FYVE
DOMAIN-CONTAINING
PROTEIN 9

(Homo sapiens) 		PF11979
(DUF3480) 		5 LEU A1046
LEU A1043
GLY A1056
TYR A1053
PRO A1049
 None
 1.09A 6ce2B-4bkwA:
undetectable		 6ce2B-4bkwA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4chb KELCH-LIKE PROTEIN 2

(Homo sapiens) 		PF01344
(Kelch_1) 		5 LEU A 449
GLY A 394
GLY A 441
GLY A 490
ARG A 486
 None
 1.03A 6ce2B-4chbA:
undetectable		 6ce2B-4chbA:
16.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fs7 UNCHARACTERIZED
PROTEIN

(Bacteroides
ovatus) 		PF13306
(LRR_5) 		6 LEU A 148
GLY A 152
GLY A 129
GLY A 106
ASN A 120
PRO A 122
 None
 1.23A 6ce2B-4fs7A:
undetectable		 6ce2B-4fs7A:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h79 CRISPR-ASSOCIATED
PROTEIN, CSE2 FAMILY

(Thermobifida
fusca) 		PF09485
(CRISPR_Cse2) 		5 LEU A 156
GLY A 113
GLY A 111
GLY A 109
TYR A 165
 None
None
None
EDO  A 301 (-4.7A)
None
 1.07A 6ce2B-4h79A:
undetectable		 6ce2B-4h79A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3g BETA-GLUCOSIDASE

(Streptomyces
venezuelae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 LEU A 453
LEU A 476
GLY A 544
GLY A 445
PRO A 479
 None
 1.12A 6ce2B-4i3gA:
undetectable		 6ce2B-4i3gA:
9.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kg7 PEPTIDASE S8 AND
S53, SUBTILISIN,
KEXIN, SEDOLISIN

(Mycolicibacterium
smegmatis) 		PF00082
(Peptidase_S8) 		5 LEU A 202
GLY A  97
GLY A 127
GLY A 132
TYR A 342
 None
 1.04A 6ce2B-4kg7A:
undetectable		 6ce2B-4kg7A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7z HPCH/HPAI ALDOLASE

(Chloroflexus
aurantiacus) 		PF03328
(HpcH_HpaI) 		5 LEU A 156
LEU A 155
GLY A 177
GLY A 270
PRO A 182
 None
 1.11A 6ce2B-4l7zA:
undetectable		 6ce2B-4l7zA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4muo UNCHARACTERIZED
PROTEIN YBIB

(Escherichia
coli) 		PF02885
(Glycos_trans_3N) 		5 LEU A 108
LEU A 105
GLY A 312
GLY A 304
PRO A 111
 None
 1.11A 6ce2B-4muoA:
undetectable		 6ce2B-4muoA:
14.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wtb BASIC PHOSPHOLIPASE
A2 HOMOLOG
BOTHROPSTOXIN-1

(Bothrops
jararacussu) 		PF00068
(Phospholip_A2_1) 		8 LEU A   2
LEU A   5
GLY A  22
GLY A  29
GLY A  32
ARG A  33
LYS A  48
TYR A  51
 None
None
None
None
None
None
ZN  A 201 ( 4.2A)
None
 0.98A 6ce2B-4wtbA:
22.9		 6ce2B-4wtbA:
85.12
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4wtb BASIC PHOSPHOLIPASE
A2 HOMOLOG
BOTHROPSTOXIN-1

(Bothrops
jararacussu) 		PF00068
(Phospholip_A2_1) 		8 LEU A   5
GLY A  22
GLY A  29
GLY A  32
ARG A  33
LYS A  48
TYR A  51
PRO A  59
 None
None
None
None
None
ZN  A 201 ( 4.2A)
None
None
 0.74A 6ce2B-4wtbA:
22.9		 6ce2B-4wtbA:
85.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yis MEGANUCLEASE I-CPAMI

(Cryphonectria
parasitica) 		PF00961
(LAGLIDADG_1) 		5 LEU A  45
LEU A  52
GLY A 176
LYS A  48
LYS A  47
 None
None
CA  A 302 (-3.9A)
None
None
 1.04A 6ce2B-4yisA:
undetectable		 6ce2B-4yisA:
19.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bnn CAPSID PROTEIN VP2

(Enterovirus D) 		PF00073
(Rhv) 		5 GLY B  90
GLY B  93
TYR B 102
ASN B 205
LYS B  81
 None
 1.09A 6ce2B-5bnnB:
undetectable		 6ce2B-5bnnB:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7c ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		5 LEU A 222
LEU A 262
GLY A 207
ASN A 481
LYS A 225
 None
 1.02A 6ce2B-5f7cA:
undetectable		 6ce2B-5f7cA:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3k SLR0280 PROTEIN

(Synechocystis
sp. PCC 6803) 		no annotation 5 LEU A  93
GLY A  84
GLY A  81
GLY A  79
ARG A 117
 None
 1.12A 6ce2B-5h3kA:
undetectable		 6ce2B-5h3kA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5inr DIPEPTIDASE

(Lactobacillus
farciminis) 		PF03577
(Peptidase_C69) 		5 LEU A 214
LEU A 211
GLY A 172
GLY A 234
ARG A 230
 None
None
None
EDO  A 509 (-4.2A)
None
 0.84A 6ce2B-5inrA:
undetectable		 6ce2B-5inrA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ktk POLYKETIDE SYNTHASE
PKSJ

(Bacillus
subtilis) 		PF08659
(KR) 		5 LEU A 221
LEU A 247
GLY A 231
GLY A 226
GLY A 251
 None
None
None
NDP  A 601 ( 4.9A)
NDP  A 601 (-3.6A)
 1.11A 6ce2B-5ktkA:
undetectable		 6ce2B-5ktkA:
12.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nck N-ACETYLMANNOSAMINE
KINASE

(Fusobacterium
nucleatum) 		PF00480
(ROK) 		5 LEU A 146
GLY A 279
GLY A 114
GLY A 119
ASN A 126
 None
 1.06A 6ce2B-5nckA:
undetectable		 6ce2B-5nckA:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5owc -

(-) 		no annotation 5 LEU A   5
GLY A  28
GLY A  30
TYR A  50
PRO A  60
 AYZ  A 202 (-4.6A)
AYZ  A 202 ( 3.5A)
AYZ  A 202 ( 3.6A)
AYZ  A 202 ( 4.9A)
None
 0.76A 6ce2B-5owcA:
18.9		 6ce2B-5owcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5owc -

(-) 		no annotation 5 LEU A   5
GLY A  28
TYR A  50
PRO A  60
LYS A  61
 AYZ  A 202 (-4.6A)
AYZ  A 202 ( 3.5A)
AYZ  A 202 ( 4.9A)
None
None
 0.88A 6ce2B-5owcA:
18.9		 6ce2B-5owcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tnv AP ENDONUCLEASE,
FAMILY PROTEIN 2

(Mycolicibacterium
smegmatis) 		PF01261
(AP_endonuc_2) 		5 LEU A 151
LEU A 148
GLY A  96
GLY A 121
TYR A 179
 None
 1.05A 6ce2B-5tnvA:
undetectable		 6ce2B-5tnvA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ul4 OXSB PROTEIN

(Bacillus
megaterium) 		PF02310
(B12-binding) 		5 LEU A 147
LEU A 152
GLY A 241
ASN A  58
LYS A 149
 None
None
B12  A 802 (-3.5A)
None
None
 0.98A 6ce2B-5ul4A:
undetectable		 6ce2B-5ul4A:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uze INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE

(Clostridium
perfringens) 		PF00478
(IMPDH) 		5 LEU A  15
GLY A 343
GLY A 433
ASN A  19
PRO A  18
 None
 1.12A 6ce2B-5uzeA:
undetectable		 6ce2B-5uzeA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlh PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8)
PF05922
(Inhibitor_I9) 		5 LEU A 304
LEU A 118
GLY A 267
GLY A 263
ASN A 298
 None
 1.13A 6ce2B-5vlhA:
undetectable		 6ce2B-5vlhA:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wvo DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1

(Homo sapiens) 		no annotation 5 GLY C 471
GLY C 468
LYS C 510
TYR C 507
PRO C 537
 None
 1.10A 6ce2B-5wvoC:
undetectable		 6ce2B-5wvoC:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wzm GROUP IIE SECRETORY
PHOSPHOLIPASE A2

(Homo sapiens) 		no annotation 5 GLY A  28
GLY A  30
TYR A  50
PRO A  60
LYS A  61
 CA  A 210 (-4.3A)
CA  A 210 (-4.2A)
None
CL  A 201 (-3.7A)
CL  A 201 (-4.0A)
 0.98A 6ce2B-5wzmA:
18.5		 6ce2B-5wzmA:
29.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ypz COFB

(Escherichia
coli) 		no annotation 5 GLY A 106
GLY A 104
ARG A 110
ASN A  82
PRO A  79
 None
 1.14A 6ce2B-5ypzA:
undetectable		 6ce2B-5ypzA:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z5c CYSTEINE SYNTHASE

(Fusobacterium
nucleatum) 		no annotation 5 LEU A 216
GLY A 186
GLY A 184
GLY A 229
ASN A 212
 None
PLP  A 401 (-3.5A)
PLP  A 401 (-3.6A)
PLP  A 401 (-3.6A)
None
 1.06A 6ce2B-5z5cA:
undetectable		 6ce2B-5z5cA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cgm RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE

(Bacillus
subtilis) 		no annotation 5 LEU A 203
LEU A 251
GLY A 225
GLY A 222
GLY A 210
 None
 1.07A 6ce2B-6cgmA:
undetectable		 6ce2B-6cgmA:
21.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gy5 -

(-) 		no annotation 5 LEU A 320
GLY A 548
GLY A 595
GLY A 359
ARG A 355
 None
EDO  A 710 (-3.3A)
EDO  A 710 (-3.2A)
None
None
 1.04A 6ce2B-6gy5A:
undetectable		 6ce2B-6gy5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gy5 -

(-) 		no annotation 5 LEU A 556
GLY A 501
GLY A 548
GLY A 595
ARG A 591
 None
None
EDO  A 710 (-3.3A)
EDO  A 710 (-3.2A)
None
 1.12A 6ce2B-6gy5A:
undetectable		 6ce2B-6gy5A:
undetectable