SIMILAR PATTERNS OF AMINO ACIDS FOR 6CDU_G_EY4G502_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d9z EXCINUCLEASE UVRABC
COMPONENT UVRB

([Bacillus]
caldotenax) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF12344
(UvrB) 		4 ILE A 422
PRO A 420
ILE A 519
THR A 451
 None
 0.76A 6cduG-1d9zA:
3.0
6cduH-1d9zA:
2.9		 6cduG-1d9zA:
19.51
6cduH-1d9zA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehy PROTEIN (SOLUBLE
EPOXIDE HYDROLASE)

(Agrobacterium
tumefaciens) 		PF00561
(Abhydrolase_1) 		4 VAL A 103
PRO A 237
THR A  31
TYR A  56
 None
 1.04A 6cduG-1ehyA:
undetectable
6cduH-1ehyA:
undetectable		 6cduG-1ehyA:
23.02
6cduH-1ehyA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcp PROTEIN (FERRIC
HYDROXAMATE UPTAKE
RECEPTOR)

(Escherichia
coli) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 GLN A  44
VAL A  46
ILE A  50
THR A  35
 None
 0.96A 6cduG-1fcpA:
0.1
6cduH-1fcpA:
undetectable		 6cduG-1fcpA:
17.48
6cduH-1fcpA:
17.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gaj HIGH-AFFINITY
BRANCHED CHAIN AMINO
ACID TRANSPORT
ATP-BINDING PROTEIN

(Methanocaldococcus
jannaschii) 		PF00005
(ABC_tran) 		4 ILE A  84
VAL A 176
PRO A 172
THR A  36
 None
 1.01A 6cduG-1gajA:
0.0
6cduH-1gajA:
0.0		 6cduG-1gajA:
23.51
6cduH-1gajA:
23.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2t 80 KDA NUCLEAR CAP
BINDING PROTEIN

(Homo sapiens) 		PF02854
(MIF4G)
PF09088
(MIF4G_like)
PF09090
(MIF4G_like_2) 		4 PRO C 273
ILE C 195
THR C 199
TYR C 202
 None
 0.78A 6cduG-1h2tC:
3.4
6cduH-1h2tC:
undetectable		 6cduG-1h2tC:
17.59
6cduH-1h2tC:
17.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k3z TRANSCRIPTION FACTOR
P65

(Mus musculus) 		PF16179
(RHD_dimer) 		4 ILE A 196
VAL A 226
ILE A 212
THR A 254
 None
 0.87A 6cduG-1k3zA:
2.5
6cduH-1k3zA:
2.3		 6cduG-1k3zA:
16.77
6cduH-1k3zA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldk CULLIN HOMOLOG

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		4 ILE B 635
GLN B 638
VAL B 639
THR B 605
 None
 1.04A 6cduG-1ldkB:
1.6
6cduH-1ldkB:
1.5		 6cduG-1ldkB:
23.21
6cduH-1ldkB:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1my7 NF-KAPPAB P65 (RELA)
SUBUNIT

(Mus musculus) 		PF16179
(RHD_dimer) 		4 ILE A 196
VAL A 226
ILE A 212
THR A 254
 None
 0.85A 6cduG-1my7A:
1.9
6cduH-1my7A:
2.1		 6cduG-1my7A:
15.74
6cduH-1my7A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qva INITIATION FACTOR 4A

(Saccharomyces
cerevisiae) 		PF00270
(DEAD) 		4 GLN A  48
ILE A  12
THR A  14
TYR A  16
 None
 1.07A 6cduG-1qvaA:
undetectable
6cduH-1qvaA:
undetectable		 6cduG-1qvaA:
19.76
6cduH-1qvaA:
19.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sq5 PANTOTHENATE KINASE

(Escherichia
coli) 		PF00485
(PRK) 		4 ILE A1290
GLN A1205
VAL A1203
THR A1125
 None
 0.82A 6cduG-1sq5A:
undetectable
6cduH-1sq5A:
undetectable		 6cduG-1sq5A:
21.85
6cduH-1sq5A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wr2 HYPOTHETICAL PROTEIN
PH1789

(Pyrococcus
horikoshii) 		PF13549
(ATP-grasp_5) 		4 ILE A 124
VAL A 122
ILE A 190
TYR A 219
 None
 1.07A 6cduG-1wr2A:
undetectable
6cduH-1wr2A:
undetectable		 6cduG-1wr2A:
22.74
6cduH-1wr2A:
22.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wza ALPHA-AMYLASE A

(Halothermothrix
orenii) 		PF00128
(Alpha-amylase) 		4 VAL A 448
ILE A 504
THR A 508
TYR A 507
 None
 1.02A 6cduG-1wzaA:
undetectable
6cduH-1wzaA:
undetectable		 6cduG-1wzaA:
21.44
6cduH-1wzaA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z48 PROBABLE
NADH-DEPENDENT
FLAVIN
OXIDOREDUCTASE YQJM

(Bacillus
subtilis) 		PF00724
(Oxidored_FMN) 		4 GLN A  52
VAL A  53
PRO A 331
ILE A  56
 None
 1.05A 6cduG-1z48A:
undetectable
6cduH-1z48A:
undetectable		 6cduG-1z48A:
22.81
6cduH-1z48A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2byo LIPOPROTEIN LPPX

(Mycobacterium
tuberculosis) 		PF07161
(LppX_LprAFG) 		4 ILE A  92
VAL A  94
ILE A  57
THR A  76
 None
None
LNL  A1216 ( 4.2A)
None
 1.04A 6cduG-2byoA:
undetectable
6cduH-2byoA:
undetectable		 6cduG-2byoA:
23.31
6cduH-2byoA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dej PROBABLE
GALACTOKINASE

(Pyrococcus
horikoshii) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		4 ILE A   2
ILE A  35
THR A  33
TYR A  32
 None
None
APW  A 402 ( 4.4A)
None
 0.78A 6cduG-2dejA:
undetectable
6cduH-2dejA:
2.0		 6cduG-2dejA:
22.88
6cduH-2dejA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hau SEROTRANSFERRIN

(Homo sapiens) 		PF00405
(Transferrin) 		4 ILE A 263
VAL A 252
ILE A  52
TYR A  45
 None
 1.04A 6cduG-2hauA:
undetectable
6cduH-2hauA:
undetectable		 6cduG-2hauA:
19.64
6cduH-2hauA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)

(Homo sapiens) 		PF03199
(GSH_synthase)
PF03917
(GSH_synth_ATP) 		4 ILE A 454
GLN A 421
VAL A 420
THR A  51
 None
 0.93A 6cduG-2hgsA:
undetectable
6cduH-2hgsA:
undetectable		 6cduG-2hgsA:
20.84
6cduH-2hgsA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hkl L,D-TRANSPEPTIDASE

(Enterococcus
faecium) 		PF03734
(YkuD)
PF12229
(PG_binding_4) 		4 PRO A 378
ILE A 345
THR A 461
TYR A 383
 None
 1.06A 6cduG-2hklA:
undetectable
6cduH-2hklA:
undetectable		 6cduG-2hklA:
21.82
6cduH-2hklA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING

(Lactococcus
lactis) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		4 ILE A 208
VAL A 409
ILE A 420
THR A 424
 None
 0.87A 6cduG-2iyoA:
undetectable
6cduH-2iyoA:
undetectable		 6cduG-2iyoA:
22.58
6cduH-2iyoA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jad YELLOW FLUORESCENT
PROTEIN GLUTAREDOXIN
FUSION PROTEIN

(Saccharomyces
cerevisiae;
Aequorea
victoria) 		PF00462
(Glutaredoxin)
PF01353
(GFP) 		4 ILE A 136
GLN A 177
THR A  97
TYR A 182
 None
 0.88A 6cduG-2jadA:
undetectable
6cduH-2jadA:
undetectable		 6cduG-2jadA:
21.27
6cduH-2jadA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA-1
F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
ISOFORMS 1 AND 2

(Gallus gallus;
Gallus gallus) 		PF01267
(F-actin_cap_A)
PF01115
(F_actin_cap_B) 		4 GLN A 205
VAL A 196
PRO B 317
ILE A 194
 None
 0.99A 6cduG-2kxpA:
undetectable
6cduH-2kxpA:
undetectable		 6cduG-2kxpA:
23.30
6cduH-2kxpA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ljk PROTEIN C17ORF37

(Homo sapiens) 		PF10262
(Rdx) 		4 ILE A  92
GLN A  51
VAL A  48
ILE A  27
 None
 1.04A 6cduG-2ljkA:
undetectable
6cduH-2ljkA:
undetectable		 6cduG-2ljkA:
17.34
6cduH-2ljkA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owp HYPOTHETICAL PROTEIN
BXE_B1374

(Paraburkholderia
xenovorans) 		PF11533
(DUF3225) 		4 ILE A   8
GLN A  11
VAL A  12
THR A 105
 None
 0.94A 6cduG-2owpA:
undetectable
6cduH-2owpA:
undetectable		 6cduG-2owpA:
17.53
6cduH-2owpA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qx2 SEX PHEROMONE
STAPH-CAM373

(Staphylococcus
aureus) 		PF07537
(CamS) 		4 VAL A 355
PRO A 392
ILE A 373
THR A 348
 None
 1.02A 6cduG-2qx2A:
undetectable
6cduH-2qx2A:
undetectable		 6cduG-2qx2A:
19.67
6cduH-2qx2A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vn7 GLUCOAMYLASE

(Trichoderma
reesei) 		PF00686
(CBM_20)
PF00723
(Glyco_hydro_15) 		4 GLN A 356
VAL A 359
ILE A 377
TYR A 384
 None
 0.82A 6cduG-2vn7A:
undetectable
6cduH-2vn7A:
1.8		 6cduG-2vn7A:
20.17
6cduH-2vn7A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu0 PHYTASE

(Klebsiella
pneumoniae) 		PF00328
(His_Phos_2) 		4 ILE A 238
VAL A 211
THR A 246
TYR A 249
 None
None
None
SO4  A1409 (-4.7A)
 0.92A 6cduG-2wu0A:
undetectable
6cduH-2wu0A:
undetectable		 6cduG-2wu0A:
21.93
6cduH-2wu0A:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wvw RBCX PROTEIN

(Anabaena sp. CA
= ATCC 33047) 		PF02341
(RcbX) 		4 VAL I  26
ILE I  70
THR I  19
TYR I  20
 None
 1.06A 6cduG-2wvwI:
undetectable
6cduH-2wvwI:
undetectable		 6cduG-2wvwI:
18.38
6cduH-2wvwI:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xn1 ALPHA-GALACTOSIDASE

(Lactobacillus
acidophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 PRO A 234
ILE A 548
THR A 545
TYR A 544
 None
 0.97A 6cduG-2xn1A:
undetectable
6cduH-2xn1A:
undetectable		 6cduG-2xn1A:
18.38
6cduH-2xn1A:
18.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zvi 2,3-DIKETO-5-METHYLT
HIOPENTYL-1-PHOSPHAT
E ENOLASE

(Bacillus
subtilis) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		4 ILE A 160
GLN A 163
ILE A 199
THR A 203
 None
 1.01A 6cduG-2zviA:
undetectable
6cduH-2zviA:
undetectable		 6cduG-2zviA:
20.60
6cduH-2zviA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zz8 LIPL32 PROTEIN

(Leptospira
interrogans) 		PF12103
(Lipl32) 		4 ILE A  71
PRO A 224
ILE A 165
THR A 163
 None
 1.04A 6cduG-2zz8A:
undetectable
6cduH-2zz8A:
undetectable		 6cduG-2zz8A:
20.78
6cduH-2zz8A:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai5 YEAST ENHANCED GREEN
FLUORESCENT
PROTEIN,UBIQUITIN

(Aequorea
victoria;
Mus musculus) 		PF00240
(ubiquitin)
PF01353
(GFP) 		4 ILE A 136
GLN A 177
THR A  97
TYR A 182
 None
None
EDO  A 317 (-3.8A)
None
 0.91A 6cduG-3ai5A:
undetectable
6cduH-3ai5A:
undetectable		 6cduG-3ai5A:
20.80
6cduH-3ai5A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bh3 ACETOACETATE
DECARBOXYLASE

(Chromobacterium
violaceum) 		PF06314
(ADC) 		4 ILE A  64
ILE A  34
THR A  36
TYR A  37
 None
 0.85A 6cduG-3bh3A:
undetectable
6cduH-3bh3A:
undetectable		 6cduG-3bh3A:
21.18
6cduH-3bh3A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bv8 TETRAHYDRODIPICOLINA
TE ACETYLTRANSFERASE

(Staphylococcus
aureus) 		PF08503
(DapH_N) 		4 ILE A  51
PRO A  37
ILE A  23
THR A  21
 None
None
None
NA  A 101 ( 4.3A)
 1.02A 6cduG-3bv8A:
undetectable
6cduH-3bv8A:
undetectable		 6cduG-3bv8A:
13.29
6cduH-3bv8A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evp GREEN FLUORESCENT
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria) 		PF01353
(GFP) 		4 ILE A 294
GLN A  90
THR A 255
TYR A  95
 None
 0.93A 6cduG-3evpA:
undetectable
6cduH-3evpA:
undetectable		 6cduG-3evpA:
21.36
6cduH-3evpA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ez1 AMINOTRANSFERASE
MOCR FAMILY

(Deinococcus
geothermalis) 		PF12897
(Aminotran_MocR) 		4 VAL A 359
ILE A 411
THR A 415
TYR A 418
 None
 0.98A 6cduG-3ez1A:
undetectable
6cduH-3ez1A:
undetectable		 6cduG-3ez1A:
22.97
6cduH-3ez1A:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbs OXIDOREDUCTASE

(Agrobacterium
fabrum) 		PF07992
(Pyr_redox_2) 		4 ILE A 105
ILE A  28
THR A  71
TYR A  69
 None
 0.95A 6cduG-3fbsA:
undetectable
6cduH-3fbsA:
undetectable		 6cduG-3fbsA:
21.01
6cduH-3fbsA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g3l PUTATIVE
UNCHARACTERIZED
MEMBRANE-ASSOCIATED
PROTEIN

(Bacteroides
fragilis) 		PF12985
(DUF3869) 		4 ILE A 221
ILE A 287
THR A 285
TYR A 284
 None
 1.01A 6cduG-3g3lA:
undetectable
6cduH-3g3lA:
undetectable		 6cduG-3g3lA:
21.41
6cduH-3g3lA:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gme POLYRIBONUCLEOTIDE
NUCLEOTIDYLTRANSFERA
SE

(Escherichia
coli) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF03726
(PNPase) 		4 ILE A 114
GLN A 112
VAL A  61
THR A  89
 MN  A 551 (-4.6A)
None
None
None
 1.04A 6cduG-3gmeA:
undetectable
6cduH-3gmeA:
undetectable		 6cduG-3gmeA:
24.08
6cduH-3gmeA:
24.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gr8 NADPH DEHYDROGENASE

(Geobacillus
kaustophilus) 		PF00724
(Oxidored_FMN) 		4 GLN A  52
VAL A  53
PRO A 331
ILE A  56
 None
 1.03A 6cduG-3gr8A:
undetectable
6cduH-3gr8A:
undetectable		 6cduG-3gr8A:
23.92
6cduH-3gr8A:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 ILE A 179
GLN A 182
VAL A 183
ILE A 264
 None
 1.06A 6cduG-3hztA:
undetectable
6cduH-3hztA:
undetectable		 6cduG-3hztA:
19.60
6cduH-3hztA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i0p MALATE DEHYDROGENASE

(Entamoeba
histolytica) 		PF02615
(Ldh_2) 		4 ILE A  11
VAL A   9
ILE A  52
THR A 348
 None
 0.97A 6cduG-3i0pA:
undetectable
6cduH-3i0pA:
undetectable		 6cduG-3i0pA:
20.49
6cduH-3i0pA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 ILE A 178
GLN A 181
VAL A 182
ILE A 263
 None
 1.03A 6cduG-3igoA:
undetectable
6cduH-3igoA:
undetectable		 6cduG-3igoA:
20.08
6cduH-3igoA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jvn ACETYLTRANSFERASE

(Aliivibrio
fischeri) 		PF00583
(Acetyltransf_1) 		4 ILE A   5
PRO A   3
ILE A  71
TYR A  95
 None
 0.96A 6cduG-3jvnA:
undetectable
6cduH-3jvnA:
undetectable		 6cduG-3jvnA:
18.21
6cduH-3jvnA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kkz UNCHARACTERIZED
PROTEIN Q5LES9

(Bacteroides
fragilis) 		PF13649
(Methyltransf_25) 		4 ILE A 176
GLN A 179
VAL A 180
TYR A 188
 None
 1.04A 6cduG-3kkzA:
undetectable
6cduH-3kkzA:
undetectable		 6cduG-3kkzA:
22.49
6cduH-3kkzA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2t PUTATIVE
OXIDOREDUCTASE

(Gluconobacter
oxydans) 		PF00248
(Aldo_ket_red) 		4 ILE A   6
VAL A 205
PRO A   9
TYR A 197
 None
 0.96A 6cduG-3n2tA:
undetectable
6cduH-3n2tA:
undetectable		 6cduG-3n2tA:
21.52
6cduH-3n2tA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oks 4-AMINOBUTYRATE
TRANSAMINASE

(Mycolicibacterium
smegmatis) 		PF00202
(Aminotran_3) 		4 ILE A 336
GLN A 108
VAL A 105
ILE A 294
 None
 1.03A 6cduG-3oksA:
undetectable
6cduH-3oksA:
undetectable		 6cduG-3oksA:
20.90
6cduH-3oksA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE ALPHA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		4 ILE A 843
ILE A 808
THR A 812
TYR A 815
 None
 1.05A 6cduG-3opyA:
undetectable
6cduH-3opyA:
undetectable		 6cduG-3opyA:
15.46
6cduH-3opyA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Escherichia
coli;
Aequorea
victoria) 		PF01353
(GFP)
PF01547
(SBP_bac_1)
PF13416
(SBP_bac_8) 		4 ILE A 410
GLN A 206
THR A 371
TYR A 211
 None
 0.91A 6cduG-3osqA:
undetectable
6cduH-3osqA:
undetectable		 6cduG-3osqA:
18.83
6cduH-3osqA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT M
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli;
Escherichia
coli) 		no annotation
no annotation 		4 ILE N 475
GLN N 472
TRP N 470
PRO M  73
 None
 1.07A 6cduG-3rkoN:
4.4
6cduH-3rkoN:
undetectable		 6cduG-3rkoN:
21.84
6cduH-3rkoN:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swl CHLORIDE
INTRACELLULAR
CHANNEL PROTEIN 1

(Homo sapiens) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		4 ILE A 199
GLN A 188
VAL A 187
ILE A 110
 None
 0.55A 6cduG-3swlA:
undetectable
6cduH-3swlA:
undetectable		 6cduG-3swlA:
21.56
6cduH-3swlA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfy N-ALPHA-ACETYLTRANSF
ERASE 50, NATE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00583
(Acetyltransf_1) 		4 GLN A 114
VAL A 113
PRO A 144
ILE A 121
 None
 0.92A 6cduG-3tfyA:
undetectable
6cduH-3tfyA:
undetectable		 6cduG-3tfyA:
20.30
6cduH-3tfyA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqi GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Coxiella
burnetii) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		4 ILE A  23
VAL A  27
PRO A 182
ILE A  10
 None
 0.94A 6cduG-3tqiA:
undetectable
6cduH-3tqiA:
undetectable		 6cduG-3tqiA:
20.79
6cduH-3tqiA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsc PROTEIN CYSO

(Aeropyrum
pernix) 		PF00291
(PALP) 		4 ILE A 280
GLN A 274
ILE A 242
THR A 238
 None
 0.98A 6cduG-3vscA:
undetectable
6cduH-3vscA:
undetectable		 6cduG-3vscA:
23.54
6cduH-3vscA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a6u OMEGA TRANSAMINASE

(Chromobacterium
violaceum) 		PF00202
(Aminotran_3) 		4 ILE A 248
VAL A 254
ILE A 147
THR A 145
 None
 0.89A 6cduG-4a6uA:
undetectable
6cduH-4a6uA:
undetectable		 6cduG-4a6uA:
21.01
6cduH-4a6uA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gr2 ATRBCX1

(Arabidopsis
thaliana) 		PF02341
(RcbX) 		4 VAL A  31
ILE A  79
THR A  24
TYR A  25
 None
 1.00A 6cduG-4gr2A:
undetectable
6cduH-4gr2A:
undetectable		 6cduG-4gr2A:
16.56
6cduH-4gr2A:
16.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hhr ALPHA-DIOXYGENASE

(Arabidopsis
thaliana) 		PF03098
(An_peroxidase) 		4 ILE A 414
GLN A 415
ILE A 401
THR A 437
 None
 0.76A 6cduG-4hhrA:
undetectable
6cduH-4hhrA:
undetectable		 6cduG-4hhrA:
18.79
6cduH-4hhrA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ip4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN

(Ruegeria sp.
TM1040) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 VAL A 295
PRO A 268
ILE A 286
THR A 275
 None
 1.04A 6cduG-4ip4A:
undetectable
6cduH-4ip4A:
undetectable		 6cduG-4ip4A:
18.98
6cduH-4ip4A:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4km3 METHIONINE
AMINOPEPTIDASE

(Streptococcus
pneumoniae) 		PF00557
(Peptidase_M24) 		4 GLN A 262
VAL A  79
ILE A 242
THR A 244
 None
 0.92A 6cduG-4km3A:
undetectable
6cduH-4km3A:
undetectable		 6cduG-4km3A:
20.77
6cduH-4km3A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kr9 PROBABLE TRNA
SULFURTRANSFERASE

(Thermotoga
maritima) 		PF02568
(ThiI)
PF02926
(THUMP) 		4 GLN A 341
ILE A 223
THR A 332
TYR A 333
 None
 0.84A 6cduG-4kr9A:
undetectable
6cduH-4kr9A:
undetectable		 6cduG-4kr9A:
19.46
6cduH-4kr9A:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l37 ARYLPHORIN

(Bombyx mori) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 GLN B 548
VAL B 500
ILE B 551
TYR B 655
 None
 1.02A 6cduG-4l37B:
undetectable
6cduH-4l37B:
1.9		 6cduG-4l37B:
17.50
6cduH-4l37B:
17.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m2j AMINOTRANSFERASE

(Streptomyces
lavendulae) 		PF00155
(Aminotran_1_2) 		4 GLN A  64
VAL A  87
ILE A  73
TYR A 220
 None
 1.04A 6cduG-4m2jA:
undetectable
6cduH-4m2jA:
undetectable		 6cduG-4m2jA:
19.33
6cduH-4m2jA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mb7 ENDONUCLEASE 8-LIKE
L720

(Acanthamoeba
polyphaga
mimivirus) 		PF06831
(H2TH) 		4 ILE A  92
ILE A  76
THR A  10
TYR A  11
 None
 0.89A 6cduG-4mb7A:
undetectable
6cduH-4mb7A:
undetectable		 6cduG-4mb7A:
22.94
6cduH-4mb7A:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mdk UBIQUITIN-CONJUGATIN
G ENZYME E2 R1

(Homo sapiens) 		PF00179
(UQ_con) 		4 ILE A 165
GLN A 168
VAL A 169
TYR A  57
 None
 0.86A 6cduG-4mdkA:
undetectable
6cduH-4mdkA:
undetectable		 6cduG-4mdkA:
20.73
6cduH-4mdkA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mio INOSITOL
2-DEHYDROGENASE/D-CH
IRO-INOSITOL
3-DEHYDROGENASE

(Lactobacillus
casei) 		PF01408
(GFO_IDH_MocA) 		4 ILE A  93
ILE A   8
THR A  34
TYR A  55
 None
None
NAI  A 401 ( 4.9A)
None
 0.91A 6cduG-4mioA:
undetectable
6cduH-4mioA:
undetectable		 6cduG-4mioA:
20.89
6cduH-4mioA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nas RIBULOSE-BISPHOSPHAT
E CARBOXYLASE

(Alicyclobacillus
acidocaldarius) 		PF00016
(RuBisCO_large) 		4 ILE A 298
VAL A 129
PRO A 262
TYR A 139
 None
 0.87A 6cduG-4nasA:
undetectable
6cduH-4nasA:
undetectable		 6cduG-4nasA:
21.93
6cduH-4nasA:
21.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ndk E23P-YFP, GFP-LIKE
FLUORESCENT
CHROMOPROTEIN FP506,
RELATED, CHIMERIC
CONSTRUCT,

(Eimeria
acervulina;
Aequorea
victoria) 		PF00046
(Homeobox)
PF01353
(GFP) 		4 ILE A 189
GLN A 230
THR A 150
TYR A 235
 None
 0.95A 6cduG-4ndkA:
undetectable
6cduH-4ndkA:
undetectable		 6cduG-4ndkA:
20.17
6cduH-4ndkA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pf1 PEPTIDASE
S15/COCE/NOND

(Thaumarchaeota
archaeon SCGC
AB-539-E09) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C) 		4 GLN A  55
VAL A  54
ILE A  50
THR A  30
 None
 1.05A 6cduG-4pf1A:
2.0
6cduH-4pf1A:
undetectable		 6cduG-4pf1A:
18.66
6cduH-4pf1A:
18.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qed ELXO

(Staphylococcus
epidermidis) 		PF13561
(adh_short_C2) 		4 VAL A  30
ILE A   8
THR A  33
TYR A  57
 None
 1.07A 6cduG-4qedA:
undetectable
6cduH-4qedA:
undetectable		 6cduG-4qedA:
21.53
6cduH-4qedA:
21.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rtb HYDG PROTEIN

(Carboxydothermus
hydrogenoformans) 		PF04055
(Radical_SAM)
PF06968
(BATS) 		4 VAL A  19
ILE A  43
THR A  12
TYR A  13
 None
 0.94A 6cduG-4rtbA:
undetectable
6cduH-4rtbA:
undetectable		 6cduG-4rtbA:
21.29
6cduH-4rtbA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rzl RESTRICTION
ENDONUCLEASE LPNPI

(Legionella
pneumophila) 		no annotation 4 ILE A  81
GLN A  79
ILE A 159
THR A 155
 None
 1.05A 6cduG-4rzlA:
undetectable
6cduH-4rzlA:
undetectable		 6cduG-4rzlA:
21.98
6cduH-4rzlA:
21.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1b LMO1466 PROTEIN

(Listeria
monocytogenes) 		PF01966
(HD) 		4 ILE A 644
VAL A 518
THR A 511
TYR A 512
 None
 0.66A 6cduG-4s1bA:
undetectable
6cduH-4s1bA:
undetectable		 6cduG-4s1bA:
21.88
6cduH-4s1bA:
21.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tnw AVERMECTIN-SENSITIVE
GLUTAMATE-GATED
CHLORIDE CHANNEL
GLUCL ALPHA

(Caenorhabditis
elegans) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		4 ILE A 229
VAL A 233
TRP A 236
PRO A 324
 None
 0.63A 6cduG-4tnwA:
18.7
6cduH-4tnwA:
18.4		 6cduG-4tnwA:
31.77
6cduH-4tnwA:
31.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uek GALACTITOL-1-PHOSPHA
TE 5-DEHYDROGENASE

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ILE A 233
GLN A 231
VAL A 164
ILE A 166
 None
 0.95A 6cduG-4uekA:
undetectable
6cduH-4uekA:
undetectable		 6cduG-4uekA:
21.31
6cduH-4uekA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ydo UNCHARACTERIZED
PROTEIN

(Candida
albicans) 		PF00432
(Prenyltrans) 		4 ILE B 526
VAL B 528
PRO B 442
ILE B 561
 None
 1.06A 6cduG-4ydoB:
undetectable
6cduH-4ydoB:
undetectable		 6cduG-4ydoB:
17.64
6cduH-4ydoB:
17.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z4m GREEN FLUORESCENT
PROTEIN,TAX1-BINDING
PROTEIN 1

(Aequorea
victoria;
Homo sapiens) 		PF01353
(GFP) 		4 ILE A 136
GLN A 177
THR A  97
TYR A 182
 None
 0.87A 6cduG-4z4mA:
undetectable
6cduH-4z4mA:
undetectable		 6cduG-4z4mA:
21.49
6cduH-4z4mA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zd5 AMSH-LIKE PROTEASE
SST2

(Schizosaccharomyces
pombe) 		PF01398
(JAB) 		4 GLN A 416
VAL A 414
ILE A 369
TYR A 411
 None
EDO  A 504 (-3.7A)
None
None
 0.96A 6cduG-4zd5A:
undetectable
6cduH-4zd5A:
undetectable		 6cduG-4zd5A:
19.27
6cduH-4zd5A:
19.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c7i GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
TESTIS-SPECIFIC

(Mus musculus) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 ILE O 208
PRO O 232
ILE O 215
TYR O 197
 None
 0.93A 6cduG-5c7iO:
undetectable
6cduH-5c7iO:
undetectable		 6cduG-5c7iO:
21.57
6cduH-5c7iO:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fku DNA POLYMERASE III
SUBUNIT ALPHA

(Escherichia
coli) 		PF01336
(tRNA_anti-codon)
PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		4 ILE A 415
GLN A 429
VAL A 515
PRO A 537
 None
 0.94A 6cduG-5fkuA:
2.3
6cduH-5fkuA:
2.2		 6cduG-5fkuA:
14.78
6cduH-5fkuA:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fol LEUCYL-TRNA
SYNTHETASE

(Cryptosporidium
muris) 		no annotation 4 ILE A 406
GLN A 296
PRO A 399
ILE A 408
 None
 1.04A 6cduG-5folA:
undetectable
6cduH-5folA:
undetectable		 6cduG-5folA:
21.04
6cduH-5folA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1k GEM-ASSOCIATED
PROTEIN 5

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		4 VAL A 507
PRO A 537
THR A 475
TYR A 474
 None
 1.00A 6cduG-5h1kA:
undetectable
6cduH-5h1kA:
undetectable		 6cduG-5h1kA:
18.12
6cduH-5h1kA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5id6 CPF1

(Lachnospiraceae
bacterium
ND2006) 		no annotation 4 ILE A1195
ILE A1211
THR A 988
TYR A 995
 None
 0.96A 6cduG-5id6A:
4.7
6cduH-5id6A:
4.6		 6cduG-5id6A:
13.29
6cduH-5id6A:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ip9 DNA-DIRECTED RNA
POLYMERASE II
SUBUNIT RPB1

(Saccharomyces
cerevisiae) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04990
(RNA_pol_Rpb1_7)
PF04992
(RNA_pol_Rpb1_6)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		4 VAL A1355
PRO A1075
ILE A1104
TYR A1349
 None
 0.97A 6cduG-5ip9A:
3.9
6cduH-5ip9A:
undetectable		 6cduG-5ip9A:
10.67
6cduH-5ip9A:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kh0 SMALL GTP-BINDING
PROTEIN

(Thermosipho
melanesiensis) 		PF01926
(MMR_HSR1) 		4 ILE A 200
GLN A 203
VAL A 204
PRO A 189
 None
 1.02A 6cduG-5kh0A:
undetectable
6cduH-5kh0A:
undetectable		 6cduG-5kh0A:
22.30
6cduH-5kh0A:
22.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kju SHIKIMATE
O-HYDROXYCINNAMOYLTR
ANSFERASE

(Arabidopsis
thaliana) 		PF02458
(Transferase) 		4 ILE A   5
GLN A 136
VAL A  95
PRO A 119
 None
 1.01A 6cduG-5kjuA:
undetectable
6cduH-5kjuA:
undetectable		 6cduG-5kjuA:
21.95
6cduH-5kjuA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m60 BETA-1,3-GLUCANASE

(Chaetomium
thermophilum) 		PF12708
(Pectate_lyase_3) 		4 VAL A 294
ILE A 308
THR A 310
TYR A 312
 None
 0.93A 6cduG-5m60A:
undetectable
6cduH-5m60A:
undetectable		 6cduG-5m60A:
18.60
6cduH-5m60A:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o30 PUTATIVE
OXIDOREDUCTASE

(Ilumatobacter
coccineus) 		PF13561
(adh_short_C2) 		4 ILE A 219
GLN A 222
TRP A 260
THR A 195
 None
 0.96A 6cduG-5o30A:
undetectable
6cduH-5o30A:
undetectable		 6cduG-5o30A:
21.94
6cduH-5o30A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o30 PUTATIVE
OXIDOREDUCTASE

(Ilumatobacter
coccineus) 		PF13561
(adh_short_C2) 		4 ILE A 219
GLN A 222
VAL A 223
TRP A 260
 None
 0.57A 6cduG-5o30A:
undetectable
6cduH-5o30A:
undetectable		 6cduG-5o30A:
21.94
6cduH-5o30A:
21.94
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5o8f GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-3,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT
ALPHA-5,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-5

(Homo sapiens) 		no annotation 5 ILE A 242
GLN A 245
VAL A 246
TRP A 249
PRO A 403
 None
 0.55A 6cduG-5o8fA:
28.5
6cduH-5o8fA:
4.7		 6cduG-5o8fA:
48.09
6cduH-5o8fA:
48.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		4 TRP T2729
ILE T2690
THR T2686
TYR T2685
 None
 1.05A 6cduG-5ojsT:
undetectable
6cduH-5ojsT:
undetectable		 6cduG-5ojsT:
6.75
6cduH-5ojsT:
6.75
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5osb PROTON-GATED ION
CHANNEL,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1

(Mus musculus;
Gloeobacter
violaceus) 		no annotation 5 ILE A 238
GLN A 241
VAL A 242
TRP A 245
PRO A 400
 A8Z  A 502 ( 3.8A)
A8Z  A 502 (-2.8A)
A8Z  A 502 (-2.9A)
A8Z  A 502 ( 2.8A)
A8Z  A 502 (-3.1A)
 0.61A 6cduG-5osbA:
26.8
6cduH-5osbA:
26.9		 6cduG-5osbA:
49.40
6cduH-5osbA:
49.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5d PTS SYSTEM, IIB
COMPONENT

(Streptococcus
pneumoniae) 		PF03830
(PTSIIB_sorb) 		4 VAL A  18
TRP A  21
ILE A  81
TYR A  25
 None
 0.84A 6cduG-5t5dA:
undetectable
6cduH-5t5dA:
undetectable		 6cduG-5t5dA:
19.33
6cduH-5t5dA:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tiz SULFOTRANSFERASE

(Schistosoma
japonicum) 		no annotation 4 ILE A  68
GLN A  72
ILE A  58
THR A  54
 None
 1.07A 6cduG-5tizA:
undetectable
6cduH-5tizA:
undetectable		 6cduG-5tizA:
21.83
6cduH-5tizA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5txf PHOSPHATIDYLCHOLINE-
STEROL
ACYLTRANSFERASE

(Homo sapiens) 		no annotation 4 VAL A 264
PRO A 254
THR A 268
TYR A 327
 None
 0.82A 6cduG-5txfA:
undetectable
6cduH-5txfA:
undetectable		 6cduG-5txfA:
20.59
6cduH-5txfA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uds LACTATE RACEMIZATION
OPERON PROTEIN LARE

(Lactobacillus
plantarum) 		PF02540
(NAD_synthase) 		4 GLN A 242
VAL A 239
ILE A 222
THR A 252
 None
 1.06A 6cduG-5udsA:
undetectable
6cduH-5udsA:
undetectable		 6cduG-5udsA:
21.28
6cduH-5udsA:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vm8 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E

(Neisseria
gonorrhoeae) 		PF04452
(Methyltrans_RNA) 		4 ILE A 131
GLN A  94
VAL A  97
ILE A 104
 None
 0.92A 6cduG-5vm8A:
undetectable
6cduH-5vm8A:
undetectable		 6cduG-5vm8A:
20.99
6cduH-5vm8A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vvm CADHERIN-23

(Homo sapiens) 		no annotation 4 VAL A2337
PRO A2317
ILE A2282
TYR A2339
 None
 0.97A 6cduG-5vvmA:
undetectable
6cduH-5vvmA:
undetectable		 6cduG-5vvmA:
undetectable
6cduH-5vvmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhu MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Bos taurus) 		no annotation 4 ILE A1372
PRO A1376
ILE A1467
THR A1463
 None
 0.99A 6cduG-6bhuA:
4.1
6cduH-6bhuA:
1.8		 6cduG-6bhuA:
undetectable
6cduH-6bhuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY

(Thermobifida
fusca) 		no annotation 4 ILE A 354
TRP A  69
ILE A 236
THR A  76
 None
 1.03A 6cduG-6c66A:
4.3
6cduH-6c66A:
4.3		 6cduG-6c66A:
undetectable
6cduH-6c66A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6q EXOSOME COMPLEX
COMPONENT RRP4

(Homo sapiens) 		no annotation 4 GLN H 173
VAL H 174
ILE H 242
THR H 246
 None
 0.82A 6cduG-6d6qH:
undetectable
6cduH-6d6qH:
undetectable		 6cduG-6d6qH:
undetectable
6cduH-6d6qH:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6d6u GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1

(Homo sapiens) 		no annotation 4 GLN B 242
VAL B 243
TRP B 246
PRO B 330
 None
 0.96A 6cduG-6d6uB:
19.4
6cduH-6d6uB:
26.1		 6cduG-6d6uB:
46.83
6cduH-6d6uB:
46.83