SIMILAR PATTERNS OF AMINO ACIDS FOR 6CDU_G_EY4G501_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cd1 CD1

(Mus musculus) 		PF07654
(C1-set)
PF16497
(MHC_I_3) 		4 ILE A  98
GLN A  99
VAL A 118
THR A 135
 None
 0.94A 6cduF-1cd1A:
3.1
6cduG-1cd1A:
2.3		 6cduF-1cd1A:
19.65
6cduG-1cd1A:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ckv PROTEIN (PROTEIN B)

(Escherichia
coli) 		PF02406
(MmoB_DmpM) 		4 ILE A  79
VAL A  68
ILE A  55
THR A  58
 None
 0.97A 6cduF-1ckvA:
undetectable
6cduG-1ckvA:
undetectable		 6cduF-1ckvA:
18.63
6cduG-1ckvA:
18.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d9z EXCINUCLEASE UVRABC
COMPONENT UVRB

([Bacillus]
caldotenax) 		PF00271
(Helicase_C)
PF04851
(ResIII)
PF12344
(UvrB) 		4 ILE A 422
PRO A 420
ILE A 519
THR A 451
 None
 0.77A 6cduF-1d9zA:
2.8
6cduG-1d9zA:
3.0		 6cduF-1d9zA:
19.51
6cduG-1d9zA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gji C-REL PROTO-ONCOGENE
PROTEIN

(Gallus gallus) 		PF00554
(RHD_DNA_bind)
PF16179
(RHD_dimer) 		4 ILE A 187
VAL A 217
ILE A 203
THR A 245
 None
 0.88A 6cduF-1gjiA:
0.1
6cduG-1gjiA:
1.3		 6cduF-1gjiA:
20.88
6cduG-1gjiA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k3z TRANSCRIPTION FACTOR
P65

(Mus musculus) 		PF16179
(RHD_dimer) 		4 ILE A 196
VAL A 226
ILE A 212
THR A 254
 None
 0.96A 6cduF-1k3zA:
1.9
6cduG-1k3zA:
2.5		 6cduF-1k3zA:
16.77
6cduG-1k3zA:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kyi ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU

(Haemophilus
influenzae) 		PF00004
(AAA)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		4 VAL A 254
PRO A  50
ILE A 100
THR A 104
 None
 0.76A 6cduF-1kyiA:
0.0
6cduG-1kyiA:
0.0		 6cduF-1kyiA:
22.85
6cduG-1kyiA:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1my7 NF-KAPPAB P65 (RELA)
SUBUNIT

(Mus musculus) 		PF16179
(RHD_dimer) 		4 ILE A 196
VAL A 226
ILE A 212
THR A 254
 None
 0.93A 6cduF-1my7A:
3.1
6cduG-1my7A:
1.9		 6cduF-1my7A:
15.74
6cduG-1my7A:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ofh ATP-DEPENDENT HSL
PROTEASE ATP-BINDING
SUBUNIT HSLU

(Haemophilus
influenzae) 		PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		4 VAL A 254
PRO A  50
ILE A 100
THR A 104
 None
 0.83A 6cduF-1ofhA:
0.0
6cduG-1ofhA:
0.0		 6cduF-1ofhA:
22.32
6cduG-1ofhA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rmu HUMAN RHINOVIRUS 14
COAT PROTEIN
(SUBUNIT VP1)

(Rhinovirus B) 		PF00073
(Rhv) 		4 GLN 1 149
VAL 1 148
ILE 1 130
THR 1 183
 None
 0.94A 6cduF-1rmu1:
undetectable
6cduG-1rmu1:
undetectable		 6cduF-1rmu1:
22.81
6cduG-1rmu1:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sq5 PANTOTHENATE KINASE

(Escherichia
coli) 		PF00485
(PRK) 		5 ILE A1290
GLN A1205
VAL A1203
PRO A1148
THR A1125
 None
 1.37A 6cduF-1sq5A:
undetectable
6cduG-1sq5A:
undetectable		 6cduF-1sq5A:
21.85
6cduG-1sq5A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t90 PROBABLE
METHYLMALONATE-SEMIA
LDEHYDE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00171
(Aldedh) 		4 ILE A 368
GLN A 305
ILE A 272
THR A 268
 None
 0.90A 6cduF-1t90A:
undetectable
6cduG-1t90A:
undetectable		 6cduF-1t90A:
20.58
6cduG-1t90A:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uc4 DIOL DEHYDRASE BETA
SUBUNIT

(Klebsiella
oxytoca) 		PF02288
(Dehydratase_MU) 		4 ILE B 128
GLN B 142
ILE B 130
THR B 138
 None
 0.85A 6cduF-1uc4B:
undetectable
6cduG-1uc4B:
undetectable		 6cduF-1uc4B:
22.02
6cduG-1uc4B:
22.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1udq RIBONUCLEASE PH

(Aquifex
aeolicus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 ILE A  94
VAL A 114
TRP A 113
ILE A  59
THR A 111
 None
 1.35A 6cduF-1udqA:
undetectable
6cduG-1udqA:
undetectable		 6cduF-1udqA:
20.73
6cduG-1udqA:
20.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7w HALOTOLERANT
ALPHA-TYPE CARBONIC
ANHYDRASE (DCA II)

(Dunaliella
salina) 		PF00194
(Carb_anhydrase) 		4 VAL A 229
PRO A 204
ILE A 125
THR A  43
 None
 0.86A 6cduF-1y7wA:
undetectable
6cduG-1y7wA:
undetectable		 6cduF-1y7wA:
21.26
6cduG-1y7wA:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yz4 DUAL SPECIFICITY
PHOSPHATASE-LIKE 15
ISOFORM A

(Homo sapiens) 		PF00782
(DSPc) 		4 ILE A 118
VAL A 114
PRO A 127
THR A 105
 None
 0.96A 6cduF-1yz4A:
undetectable
6cduG-1yz4A:
undetectable		 6cduF-1yz4A:
19.12
6cduG-1yz4A:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b2x INTEGRIN ALPHA-1

(Rattus
norvegicus) 		PF00092
(VWA) 		4 GLN A 271
VAL A 269
ILE A 230
THR A 226
 None
 1.01A 6cduF-2b2xA:
undetectable
6cduG-2b2xA:
undetectable		 6cduF-2b2xA:
20.76
6cduG-2b2xA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2byo LIPOPROTEIN LPPX

(Mycobacterium
tuberculosis) 		PF07161
(LppX_LprAFG) 		4 ILE A  92
VAL A  94
ILE A  57
THR A  76
 None
None
LNL  A1216 ( 4.2A)
None
 0.98A 6cduF-2byoA:
undetectable
6cduG-2byoA:
undetectable		 6cduF-2byoA:
23.31
6cduG-2byoA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bzl TYROSINE-PROTEIN
PHOSPHATASE,
NON-RECEPTOR TYPE 14

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 ILE A 980
GLN A1000
VAL A1002
ILE A1117
 None
 1.00A 6cduF-2bzlA:
undetectable
6cduG-2bzlA:
undetectable		 6cduF-2bzlA:
21.58
6cduG-2bzlA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cdq ASPARTOKINASE

(Arabidopsis
thaliana) 		PF00696
(AA_kinase) 		4 ILE A  27
VAL A  30
ILE A 240
THR A 236
 None
 0.96A 6cduF-2cdqA:
undetectable
6cduG-2cdqA:
undetectable		 6cduF-2cdqA:
20.39
6cduG-2cdqA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2glw 92AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		no annotation 4 ILE A  19
VAL A  62
ILE A  37
THR A  53
 None
 0.94A 6cduF-2glwA:
undetectable
6cduG-2glwA:
undetectable		 6cduF-2glwA:
12.92
6cduG-2glwA:
12.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h0q SUPPRESSOR OF T-CELL
RECEPTOR SIGNALING 1

(Mus musculus) 		PF00300
(His_Phos_1) 		4 ILE A 452
VAL A 455
ILE A 470
THR A 466
 None
 0.98A 6cduF-2h0qA:
undetectable
6cduG-2h0qA:
undetectable		 6cduF-2h0qA:
22.48
6cduG-2h0qA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)

(Homo sapiens) 		PF03199
(GSH_synthase)
PF03917
(GSH_synth_ATP) 		4 ILE A 454
GLN A 421
VAL A 420
THR A  51
 None
 0.95A 6cduF-2hgsA:
undetectable
6cduG-2hgsA:
undetectable		 6cduF-2hgsA:
20.84
6cduG-2hgsA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2inp PHENOL HYDROXYLASE
COMPONENT PHN

(Pseudomonas
stutzeri) 		PF02332
(Phenol_Hydrox)
PF04945
(YHS) 		4 ILE A 262
GLN A 259
VAL A 258
ILE A 244
 None
 1.00A 6cduF-2inpA:
2.3
6cduG-2inpA:
2.2		 6cduF-2inpA:
19.28
6cduG-2inpA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iqf CATALASE

(Helicobacter
pylori) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		4 GLN A 263
VAL A 264
ILE A  72
THR A  76
 None
MHO  A 292 ( 4.8A)
None
None
 0.90A 6cduF-2iqfA:
undetectable
6cduG-2iqfA:
undetectable		 6cduF-2iqfA:
20.32
6cduG-2iqfA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iyo 6-PHOSPHOGLUCONATE
DEHYDROGENASE,
DECARBOXYLATING

(Lactococcus
lactis) 		PF00393
(6PGD)
PF03446
(NAD_binding_2) 		4 ILE A 208
VAL A 409
ILE A 420
THR A 424
 None
 0.96A 6cduF-2iyoA:
undetectable
6cduG-2iyoA:
undetectable		 6cduF-2iyoA:
22.58
6cduG-2iyoA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kbn CONSERVED PROTEIN

(Methanosarcina
mazei) 		no annotation 4 GLN A  84
VAL A  83
ILE A  11
THR A   6
 None
 1.00A 6cduF-2kbnA:
undetectable
6cduG-2kbnA:
undetectable		 6cduF-2kbnA:
17.34
6cduG-2kbnA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kxp F-ACTIN-CAPPING
PROTEIN SUBUNIT
ALPHA-1
F-ACTIN-CAPPING
PROTEIN SUBUNIT BETA
ISOFORMS 1 AND 2

(Gallus gallus;
Gallus gallus) 		PF01267
(F-actin_cap_A)
PF01115
(F_actin_cap_B) 		4 GLN A 205
VAL A 196
PRO B 317
ILE A 194
 None
 0.98A 6cduF-2kxpA:
undetectable
6cduG-2kxpA:
undetectable		 6cduF-2kxpA:
23.30
6cduG-2kxpA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ljk PROTEIN C17ORF37

(Homo sapiens) 		PF10262
(Rdx) 		4 ILE A  92
GLN A  51
VAL A  48
ILE A  27
 None
 1.00A 6cduF-2ljkA:
undetectable
6cduG-2ljkA:
undetectable		 6cduF-2ljkA:
17.34
6cduG-2ljkA:
17.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN

(Porphyromonas
gingivalis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		4 ILE A 286
GLN A 287
VAL A 309
ILE A 317
 ILE  A 286 ( 0.7A)
GLN  A 287 ( 0.6A)
VAL  A 309 ( 0.6A)
ILE  A 317 ( 0.7A)
 0.98A 6cduF-2nvvA:
undetectable
6cduG-2nvvA:
undetectable		 6cduF-2nvvA:
23.26
6cduG-2nvvA:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o61 TRANSCRIPTION FACTOR
P65/INTERFERON
REGULATORY FACTOR
7/INTERFERON
REGULATORY FACTOR 3
FUSION PROTEIN

(Homo sapiens) 		PF00554
(RHD_DNA_bind)
PF00605
(IRF)
PF16179
(RHD_dimer) 		4 ILE A 196
VAL A 226
ILE A 212
THR A 254
 None
 0.85A 6cduF-2o61A:
undetectable
6cduG-2o61A:
undetectable		 6cduF-2o61A:
20.38
6cduG-2o61A:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oua SERINE PROTEASE

(Nocardiopsis
alba) 		PF00089
(Trypsin) 		4 ILE A  17
VAL A  44
ILE A  66
THR A  36
 None
 1.01A 6cduF-2ouaA:
undetectable
6cduG-2ouaA:
undetectable		 6cduF-2ouaA:
21.21
6cduG-2ouaA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owp HYPOTHETICAL PROTEIN
BXE_B1374

(Paraburkholderia
xenovorans) 		PF11533
(DUF3225) 		4 ILE A   8
GLN A  11
VAL A  12
THR A 105
 None
 0.82A 6cduF-2owpA:
undetectable
6cduG-2owpA:
undetectable		 6cduF-2owpA:
17.53
6cduG-2owpA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pmt GLUTATHIONE
TRANSFERASE

(Proteus
mirabilis) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 ILE A  46
GLN A  56
VAL A  54
ILE A  30
THR A   6
 None
 1.41A 6cduF-2pmtA:
3.9
6cduG-2pmtA:
2.1		 6cduF-2pmtA:
21.23
6cduG-2pmtA:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pq4 PROTEIN NAPD

(Escherichia
coli) 		PF03927
(NapD) 		4 GLN A  16
VAL A  15
ILE A  25
THR A  27
 None
 0.99A 6cduF-2pq4A:
undetectable
6cduG-2pq4A:
undetectable		 6cduF-2pq4A:
16.49
6cduG-2pq4A:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qe7 ATP SYNTHASE SUBUNIT
BETA

(Bacillus sp.
TA2.A1) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		5 ILE D  16
VAL D  42
PRO D  24
ILE D  32
THR D  39
 None
 1.15A 6cduF-2qe7D:
undetectable
6cduG-2qe7D:
undetectable		 6cduF-2qe7D:
22.34
6cduG-2qe7D:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qn0 NEUROTOXIN

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		4 ILE A 192
PRO A 196
ILE A  43
THR A  40
 None
 0.92A 6cduF-2qn0A:
undetectable
6cduG-2qn0A:
undetectable		 6cduF-2qn0A:
22.35
6cduG-2qn0A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qx2 SEX PHEROMONE
STAPH-CAM373

(Staphylococcus
aureus) 		PF07537
(CamS) 		4 VAL A 355
PRO A 392
ILE A 373
THR A 348
 None
 0.97A 6cduF-2qx2A:
undetectable
6cduG-2qx2A:
undetectable		 6cduF-2qx2A:
19.67
6cduG-2qx2A:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdl CHYMASE 2

(Mesocricetus
auratus) 		PF00089
(Trypsin) 		4 ILE A 231
GLN A 210
ILE A  47
THR A 120
 None
 0.93A 6cduF-2rdlA:
undetectable
6cduG-2rdlA:
undetectable		 6cduF-2rdlA:
19.21
6cduG-2rdlA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w3j CARBOHYDRATE BINDING
MODULE

(uncultured
bacterium) 		PF16990
(CBM_35) 		4 ILE A 124
VAL A 126
ILE A  99
THR A  52
 None
 1.00A 6cduF-2w3jA:
undetectable
6cduG-2w3jA:
undetectable		 6cduF-2w3jA:
18.35
6cduG-2w3jA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxm MYOSIN-BINDING
PROTEIN C, SLOW-TYPE

(Homo sapiens) 		PF07679
(I-set) 		4 ILE A  64
GLN A  62
VAL A  30
THR A  89
 None
 0.83A 6cduF-2yxmA:
2.1
6cduG-2yxmA:
undetectable		 6cduF-2yxmA:
14.80
6cduG-2yxmA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a21 PUTATIVE SECRETED
ALPHA-GALACTOSIDASE

(Streptomyces
avermitilis) 		PF00652
(Ricin_B_lectin)
PF16499
(Melibiase_2) 		4 ILE A  75
GLN A  78
VAL A  79
ILE A 130
 None
 0.94A 6cduF-3a21A:
2.2
6cduG-3a21A:
undetectable		 6cduF-3a21A:
19.24
6cduG-3a21A:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cxb PROTEIN SIFA

(Salmonella
enterica) 		PF06767
(Sif) 		4 ILE A 294
GLN A 297
VAL A 298
ILE A 181
 None
 0.87A 6cduF-3cxbA:
undetectable
6cduG-3cxbA:
undetectable		 6cduF-3cxbA:
20.89
6cduG-3cxbA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dnf 4-HYDROXY-3-METHYLBU
T-2-ENYL DIPHOSPHATE
REDUCTASE

(Aquifex
aeolicus) 		PF02401
(LYTB) 		4 ILE A 270
GLN A 273
VAL A 274
ILE A 241
 None
 0.98A 6cduF-3dnfA:
undetectable
6cduG-3dnfA:
undetectable		 6cduF-3dnfA:
21.70
6cduG-3dnfA:
21.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dxn CALMODULIN-LIKE
DOMAIN PROTEIN
KINASE ISOFORM 3

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		4 ILE A 126
GLN A 129
VAL A 130
ILE A 211
 None
 0.95A 6cduF-3dxnA:
undetectable
6cduG-3dxnA:
undetectable		 6cduF-3dxnA:
21.01
6cduG-3dxnA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd5 SELENIDE, WATER
DIKINASE 1

(Homo sapiens) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		4 ILE A 144
VAL A 128
PRO A  91
THR A 133
 None
 1.00A 6cduF-3fd5A:
undetectable
6cduG-3fd5A:
undetectable		 6cduF-3fd5A:
20.90
6cduG-3fd5A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gpi NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E

(Methylobacillus
flagellatus) 		PF13460
(NAD_binding_10) 		4 ILE A   4
VAL A  66
PRO A  62
THR A 148
 None
 1.01A 6cduF-3gpiA:
undetectable
6cduG-3gpiA:
undetectable		 6cduF-3gpiA:
23.38
6cduG-3gpiA:
23.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hzt CALCIUM-DEPENDENT
PROTEIN KINASE 3

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 ILE A 179
GLN A 182
VAL A 183
ILE A 264
 None
 0.85A 6cduF-3hztA:
undetectable
6cduG-3hztA:
undetectable		 6cduF-3hztA:
19.60
6cduG-3hztA:
19.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i0p MALATE DEHYDROGENASE

(Entamoeba
histolytica) 		PF02615
(Ldh_2) 		4 ILE A  11
VAL A   9
ILE A  52
THR A 348
 None
 1.00A 6cduF-3i0pA:
undetectable
6cduG-3i0pA:
undetectable		 6cduF-3i0pA:
20.49
6cduG-3i0pA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6s SUBTILISIN-LIKE
PROTEASE

(Solanum
lycopersicum) 		PF00082
(Peptidase_S8) 		4 ILE A 356
GLN A 451
VAL A 452
THR A 463
 None
 1.00A 6cduF-3i6sA:
undetectable
6cduG-3i6sA:
undetectable		 6cduF-3i6sA:
20.10
6cduG-3i6sA:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ife PEPTIDASE T

(Bacillus
anthracis) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		4 ILE A 402
VAL A 398
ILE A 373
THR A 375
 None
 1.00A 6cduF-3ifeA:
undetectable
6cduG-3ifeA:
undetectable		 6cduF-3ifeA:
19.78
6cduG-3ifeA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3igo CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 ILE A 178
GLN A 181
VAL A 182
ILE A 263
 None
 0.87A 6cduF-3igoA:
undetectable
6cduG-3igoA:
undetectable		 6cduF-3igoA:
20.08
6cduG-3igoA:
20.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l6r SERINE RACEMASE

(Homo sapiens) 		PF00291
(PALP) 		4 ILE A 252
VAL A 184
ILE A 259
THR A 261
 None
LLP  A  56 ( 4.4A)
None
None
 1.01A 6cduF-3l6rA:
undetectable
6cduG-3l6rA:
undetectable		 6cduF-3l6rA:
21.94
6cduG-3l6rA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lac PYRROLIDONE-CARBOXYL
ATE PEPTIDASE

(Bacillus
anthracis) 		PF01470
(Peptidase_C15) 		4 ILE A 193
VAL A 197
ILE A  37
THR A   3
 None
 0.90A 6cduF-3lacA:
undetectable
6cduG-3lacA:
undetectable		 6cduF-3lacA:
22.56
6cduG-3lacA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lij CALCIUM/CALMODULIN
DEPENDENT PROTEIN
KINASE WITH A KINASE
DOMAIN AND 4
CALMODULIN LIKE EF
HANDS

(Cryptosporidium
parvum) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 ILE A 164
GLN A 167
VAL A 168
ILE A 249
 None
 0.99A 6cduF-3lijA:
undetectable
6cduG-3lijA:
undetectable		 6cduF-3lijA:
18.70
6cduG-3lijA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ma6 CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		4 ILE A 137
GLN A 140
VAL A 141
ILE A 222
 None
 0.99A 6cduF-3ma6A:
undetectable
6cduG-3ma6A:
undetectable		 6cduF-3ma6A:
19.83
6cduG-3ma6A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml0 PENICILLIN G
ACYLASE, ALPHA
SUBUNIT
PENICILLIN G
ACYLASE, BETA
SUBUNIT

(Alcaligenes
faecalis;
Alcaligenes
faecalis) 		PF01804
(Penicil_amidase)
PF01804
(Penicil_amidase) 		4 ILE B 205
GLN B 203
VAL B 207
THR A 155
 None
 0.97A 6cduF-3ml0B:
undetectable
6cduG-3ml0B:
undetectable		 6cduF-3ml0B:
21.90
6cduG-3ml0B:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmt FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Bartonella
henselae) 		PF00274
(Glycolytic) 		4 ILE A 221
VAL A 257
TRP A 287
THR A 252
 None
 0.74A 6cduF-3mmtA:
undetectable
6cduG-3mmtA:
undetectable		 6cduF-3mmtA:
20.00
6cduG-3mmtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o1h PERIPLASMIC PROTEIN
TORT

(Vibrio
parahaemolyticus) 		PF00532
(Peripla_BP_1) 		5 VAL B 138
TRP B 140
PRO B 178
ILE B 302
THR B 271
 None
 1.25A 6cduF-3o1hB:
undetectable
6cduG-3o1hB:
undetectable		 6cduF-3o1hB:
20.40
6cduG-3o1hB:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oks 4-AMINOBUTYRATE
TRANSAMINASE

(Mycolicibacterium
smegmatis) 		PF00202
(Aminotran_3) 		4 ILE A 336
GLN A 108
VAL A 105
ILE A 294
 None
 0.99A 6cduF-3oksA:
undetectable
6cduG-3oksA:
undetectable		 6cduF-3oksA:
20.90
6cduG-3oksA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rjy ENDOGLUCANASE
FNCEL5A

(Fervidobacterium
nodosum) 		PF00150
(Cellulase) 		4 ILE A 145
GLN A 148
VAL A 149
ILE A  85
 None
 0.98A 6cduF-3rjyA:
undetectable
6cduG-3rjyA:
undetectable		 6cduF-3rjyA:
22.64
6cduG-3rjyA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT M
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli;
Escherichia
coli) 		no annotation
no annotation 		5 ILE N 475
GLN N 472
TRP M  71
PRO M  73
ILE N 393
 None
 1.46A 6cduF-3rkoN:
1.5
6cduG-3rkoN:
4.4		 6cduF-3rkoN:
21.84
6cduG-3rkoN:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stg 2-DEHYDRO-3-DEOXYPHO
SPHOOCTONATE
ALDOLASE

(Neisseria
meningitidis) 		PF00793
(DAHP_synth_1) 		4 ILE A 193
VAL A  17
PRO A 191
ILE A  50
 None
 1.00A 6cduF-3stgA:
undetectable
6cduG-3stgA:
undetectable		 6cduF-3stgA:
22.16
6cduG-3stgA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swl CHLORIDE
INTRACELLULAR
CHANNEL PROTEIN 1

(Homo sapiens) 		PF13409
(GST_N_2)
PF13410
(GST_C_2) 		4 ILE A 199
GLN A 188
VAL A 187
ILE A 110
 None
 0.68A 6cduF-3swlA:
undetectable
6cduG-3swlA:
undetectable		 6cduF-3swlA:
21.56
6cduG-3swlA:
21.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		4 ILE A 154
GLN A 157
VAL A 158
ILE A 239
 None
 0.90A 6cduF-3sxfA:
undetectable
6cduG-3sxfA:
undetectable		 6cduF-3sxfA:
21.10
6cduG-3sxfA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfy N-ALPHA-ACETYLTRANSF
ERASE 50, NATE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00583
(Acetyltransf_1) 		4 GLN A 114
VAL A 113
PRO A 144
ILE A 121
 None
 0.80A 6cduF-3tfyA:
undetectable
6cduG-3tfyA:
undetectable		 6cduF-3tfyA:
20.30
6cduG-3tfyA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqi GMP SYNTHASE
[GLUTAMINE-HYDROLYZI
NG]

(Coxiella
burnetii) 		PF00117
(GATase)
PF00958
(GMP_synt_C)
PF02540
(NAD_synthase) 		4 ILE A  23
VAL A  27
PRO A 182
ILE A  10
 None
 0.89A 6cduF-3tqiA:
undetectable
6cduG-3tqiA:
undetectable		 6cduF-3tqiA:
20.79
6cduG-3tqiA:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uat DISKS LARGE HOMOLOG
1

(Rattus
norvegicus) 		PF00625
(Guanylate_kin)
PF07653
(SH3_2) 		4 ILE A 887
GLN A 890
VAL A 891
ILE A 726
 None
 0.75A 6cduF-3uatA:
undetectable
6cduG-3uatA:
undetectable		 6cduF-3uatA:
21.10
6cduG-3uatA:
21.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uon HUMAN M2 MUSCARINIC
ACETYLCHOLINE,
RECEPTOR T4 LYSOZYME
FUSION PROTEIN

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		4 ILE A 398
PRO A 402
ILE A 435
THR A 434
 None
 0.94A 6cduF-3uonA:
3.7
6cduG-3uonA:
3.8		 6cduF-3uonA:
22.13
6cduG-3uonA:
22.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vcx GLYOXALASE/BLEOMYCIN
RESISTANCE
PROTEIN/DIOXYGENASE
DOMAIN

(Rhodopseudomonas
palustris) 		PF00903
(Glyoxalase) 		4 ILE A 118
VAL A 116
PRO A  93
THR A  12
 None
 0.93A 6cduF-3vcxA:
undetectable
6cduG-3vcxA:
undetectable		 6cduF-3vcxA:
17.80
6cduG-3vcxA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w9y DISKS LARGE HOMOLOG
1

(Homo sapiens) 		PF00625
(Guanylate_kin) 		4 ILE A 902
GLN A 905
VAL A 906
ILE A 741
 None
 0.80A 6cduF-3w9yA:
undetectable
6cduG-3w9yA:
undetectable		 6cduF-3w9yA:
20.92
6cduG-3w9yA:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wew HTDX DEHYDRATASE

(Mycobacterium
tuberculosis) 		PF01575
(MaoC_dehydratas) 		4 ILE A  61
GLN A 120
ILE A 182
THR A 180
 None
 1.00A 6cduF-3wewA:
undetectable
6cduG-3wewA:
undetectable		 6cduF-3wewA:
19.82
6cduG-3wewA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wov OLIGOSACCHARYL
TRANSFERASE

(Pyrococcus
abyssi) 		no annotation 4 ILE A 696
VAL A 690
ILE A 606
THR A 604
 None
 0.98A 6cduF-3wovA:
undetectable
6cduG-3wovA:
undetectable		 6cduF-3wovA:
21.63
6cduG-3wovA:
21.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a6u OMEGA TRANSAMINASE

(Chromobacterium
violaceum) 		PF00202
(Aminotran_3) 		4 ILE A 248
VAL A 254
ILE A 147
THR A 145
 None
 0.87A 6cduF-4a6uA:
undetectable
6cduG-4a6uA:
undetectable		 6cduF-4a6uA:
21.01
6cduG-4a6uA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asi ACETYL-COA
CARBOXYLASE 1

(Homo sapiens) 		PF01039
(Carboxyl_trans) 		4 ILE A1751
VAL A1753
ILE A1638
THR A1633
 None
 0.97A 6cduF-4asiA:
undetectable
6cduG-4asiA:
undetectable		 6cduF-4asiA:
17.91
6cduG-4asiA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bs9 TRUD

(uncultured
Prochloron sp.
06037A) 		PF02624
(YcaO) 		4 ILE A 122
VAL A 127
PRO A 191
THR A 114
 None
 0.96A 6cduF-4bs9A:
undetectable
6cduG-4bs9A:
undetectable		 6cduF-4bs9A:
19.08
6cduG-4bs9A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckb MRNA-CAPPING ENZYME
CATALYTIC SUBUNIT

(Vaccinia virus) 		PF03291
(Pox_MCEL)
PF10640
(Pox_ATPase-GT) 		4 ILE A 149
GLN A  60
ILE A 158
THR A 153
 None
 0.84A 6cduF-4ckbA:
undetectable
6cduG-4ckbA:
undetectable		 6cduF-4ckbA:
18.95
6cduG-4ckbA:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dgw PRE-MRNA-SPLICING
FACTOR PRP11

(Saccharomyces
cerevisiae) 		PF16835
(SF3A2) 		4 ILE C 155
GLN C 156
VAL C 157
ILE C 209
 None
 0.94A 6cduF-4dgwC:
undetectable
6cduG-4dgwC:
undetectable		 6cduF-4dgwC:
11.07
6cduG-4dgwC:
11.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyj BROAD SPECIFICITY
AMINO ACID RACEMASE

(Pseudomonas
putida) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 ILE A 341
VAL A 343
ILE A 316
THR A 351
 None
None
None
GOL  A 508 (-4.6A)
 1.00A 6cduF-4dyjA:
undetectable
6cduG-4dyjA:
undetectable		 6cduF-4dyjA:
21.18
6cduG-4dyjA:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dza LYSINE RACEMASE

(Proteus
mirabilis) 		PF00842
(Ala_racemase_C)
PF01168
(Ala_racemase_N) 		4 ILE A 334
VAL A 352
ILE A 314
THR A 349
 None
 0.97A 6cduF-4dzaA:
undetectable
6cduG-4dzaA:
undetectable		 6cduF-4dzaA:
22.46
6cduG-4dzaA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0s 5-METHYLTHIOADENOSIN
E/S-ADENOSYLHOMOCYST
EINE DEAMINASE

(Chromobacterium
violaceum) 		PF01979
(Amidohydro_1) 		4 ILE A 357
GLN A 369
ILE A  67
THR A 124
 None
 1.01A 6cduF-4f0sA:
undetectable
6cduG-4f0sA:
undetectable		 6cduF-4f0sA:
22.70
6cduG-4f0sA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fm9 DNA TOPOISOMERASE
2-ALPHA

(Homo sapiens) 		PF00521
(DNA_topoisoIV)
PF01751
(Toprim)
PF16898
(TOPRIM_C) 		4 ILE A 510
VAL A 514
ILE A 536
THR A 456
 None
 0.84A 6cduF-4fm9A:
undetectable
6cduG-4fm9A:
2.6		 6cduF-4fm9A:
17.77
6cduG-4fm9A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmz INTERNALIN

(Listeria
monocytogenes) 		PF12354
(Internalin_N)
PF12799
(LRR_4)
PF13855
(LRR_8) 		4 ILE A  58
VAL A  71
ILE A  48
THR A  40
 None
 1.00A 6cduF-4fmzA:
undetectable
6cduG-4fmzA:
undetectable		 6cduF-4fmzA:
24.25
6cduG-4fmzA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fnq ALPHA-GALACTOSIDASE
AGAB

(Geobacillus
stearothermophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		4 ILE A 618
GLN A 621
VAL A 622
ILE A 360
 None
 0.66A 6cduF-4fnqA:
undetectable
6cduG-4fnqA:
undetectable		 6cduF-4fnqA:
18.90
6cduG-4fnqA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fom POLIOVIRUS
RECEPTOR-RELATED
PROTEIN 3

(Homo sapiens) 		PF07686
(V-set)
PF08205
(C2-set_2) 		4 ILE A 175
PRO A 178
ILE A 228
THR A 216
 None
 0.92A 6cduF-4fomA:
undetectable
6cduG-4fomA:
undetectable		 6cduF-4fomA:
22.48
6cduG-4fomA:
22.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9k ROTENONE-INSENSITIVE
NADH-UBIQUINONE
OXIDOREDUCTASE

(Saccharomyces
cerevisiae) 		PF07992
(Pyr_redox_2) 		4 ILE A 173
VAL A  56
ILE A  72
THR A  74
 ILE  A 173 ( 0.4A)
VAL  A  56 ( 0.6A)
ILE  A  72 ( 0.4A)
THR  A  74 ( 0.8A)
 0.92A 6cduF-4g9kA:
undetectable
6cduG-4g9kA:
undetectable		 6cduF-4g9kA:
20.88
6cduG-4g9kA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gz8 SEMAPHORIN-3A

(Mus musculus) 		PF01403
(Sema) 		4 VAL A 327
PRO A 420
ILE A 451
THR A 453
 None
 0.90A 6cduF-4gz8A:
undetectable
6cduG-4gz8A:
undetectable		 6cduF-4gz8A:
16.28
6cduG-4gz8A:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h63 MEDIATOR OF RNA
POLYMERASE II
TRANSCRIPTION
SUBUNIT 22

(Schizosaccharomyces
pombe) 		PF06179
(Med22) 		4 ILE V  77
VAL V  73
ILE V  21
THR V  25
 None
 1.00A 6cduF-4h63V:
3.7
6cduG-4h63V:
3.6		 6cduF-4h63V:
19.70
6cduG-4h63V:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hhr ALPHA-DIOXYGENASE

(Arabidopsis
thaliana) 		PF03098
(An_peroxidase) 		4 ILE A 414
GLN A 415
ILE A 401
THR A 437
 None
 0.89A 6cduF-4hhrA:
2.4
6cduG-4hhrA:
undetectable		 6cduF-4hhrA:
18.79
6cduG-4hhrA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iqf METHIONYL-TRNA
FORMYLTRANSFERASE

(Bacillus
anthracis) 		PF00551
(Formyl_trans_N)
PF02911
(Formyl_trans_C) 		4 GLN A  90
VAL A  92
PRO A  63
ILE A  83
 None
 0.93A 6cduF-4iqfA:
undetectable
6cduG-4iqfA:
undetectable		 6cduF-4iqfA:
23.20
6cduG-4iqfA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jyk HTH-TYPE
TRANSCRIPTIONAL
REGULATOR RUTR

(Escherichia
coli) 		PF00440
(TetR_N)
PF08362
(TetR_C_3) 		4 ILE A 145
VAL A 149
PRO A  90
ILE A 157
 None
None
SO4  A 302 (-3.7A)
None
 0.97A 6cduF-4jykA:
3.2
6cduG-4jykA:
3.0		 6cduF-4jykA:
19.12
6cduG-4jykA:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kdx GLUTATHIONE
S-TRANSFERASE DOMAIN

(Paraburkholderia
graminis) 		PF00043
(GST_C)
PF13417
(GST_N_3) 		4 ILE A 153
GLN A 145
VAL A 142
ILE A 169
 None
 1.01A 6cduF-4kdxA:
3.8
6cduG-4kdxA:
3.8		 6cduF-4kdxA:
20.86
6cduG-4kdxA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1f ACYL-COA
DEHYDROGENASE DOMAIN
PROTEIN

(Acidaminococcus
fermentans) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 VAL A 168
PRO A  97
ILE A 157
THR A 126
 None
None
FAD  A 401 (-4.3A)
FAD  A 401 ( 3.3A)
 0.98A 6cduF-4l1fA:
2.4
6cduG-4l1fA:
3.2		 6cduF-4l1fA:
20.15
6cduG-4l1fA:
20.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lk2 PRE-MRNA-PROCESSING
ATP-DEPENDENT RNA
HELICASE PRP5

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C) 		4 GLN A 317
VAL A 318
ILE A 384
THR A 382
 None
 0.89A 6cduF-4lk2A:
undetectable
6cduG-4lk2A:
undetectable		 6cduF-4lk2A:
21.88
6cduG-4lk2A:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lso TYPE IV SECRETION
SYSTEM PROTEIN VIRB8

(Bartonella
quintana) 		PF04335
(VirB8) 		4 ILE A 199
GLN A 177
VAL A 178
THR A 102
 None
 1.00A 6cduF-4lsoA:
undetectable
6cduG-4lsoA:
undetectable		 6cduF-4lsoA:
19.69
6cduG-4lsoA:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n2x DL-2-HALOACID
DEHALOGENASE

(Methylobacterium
sp. CPA1) 		PF10778
(DehI) 		4 ILE A  42
TRP A  37
ILE A 274
THR A 278
 None
 1.01A 6cduF-4n2xA:
undetectable
6cduG-4n2xA:
1.9		 6cduF-4n2xA:
21.13
6cduG-4n2xA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nen INTEGRIN ALPHA-X

(Homo sapiens) 		PF00092
(VWA)
PF01839
(FG-GAP)
PF08441
(Integrin_alpha2) 		4 ILE A 995
GLN A1042
VAL A1045
THR A1075
 None
 0.99A 6cduF-4nenA:
3.3
6cduG-4nenA:
3.3		 6cduF-4nenA:
15.46
6cduG-4nenA:
15.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nnb OBCA, OXALATE
BIOSYNTHETIC
COMPONENT A

(Burkholderia
glumae) 		PF05853
(BKACE) 		4 ILE A 201
PRO A  15
ILE A 206
THR A 210
 None
 0.99A 6cduF-4nnbA:
undetectable
6cduG-4nnbA:
undetectable		 6cduF-4nnbA:
20.40
6cduG-4nnbA:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nyq MILK PROTEIN

(Diploptera
punctata) 		no annotation 4 ILE A  29
GLN A  32
ILE A  36
THR A  52
 None
EIC  A 208 (-3.8A)
OLA  A 207 ( 4.6A)
NAG  A 201 (-3.7A)
 0.98A 6cduF-4nyqA:
undetectable
6cduG-4nyqA:
undetectable		 6cduF-4nyqA:
16.72
6cduG-4nyqA:
16.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4otk MYCOBACTERIAL ENZYME
RV2971

(Mycobacterium
tuberculosis) 		PF00248
(Aldo_ket_red) 		4 ILE A 169
VAL A 145
ILE A 153
THR A 163
 None
 0.97A 6cduF-4otkA:
undetectable
6cduG-4otkA:
undetectable		 6cduF-4otkA:
22.46
6cduG-4otkA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxv CHITINASE A

(Pteris
ryukyuensis) 		PF01476
(LysM) 		4 ILE A   7
GLN A  43
VAL A  44
THR A   3
 None
 0.95A 6cduF-4pxvA:
undetectable
6cduG-4pxvA:
undetectable		 6cduF-4pxvA:
10.07
6cduG-4pxvA:
10.07