SIMILAR PATTERNS OF AMINO ACIDS FOR 6CDU_E_EY4E500_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a76 FLAP ENDONUCLEASE-1
PROTEIN

(Methanocaldococcus
jannaschii) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		4 ILE A  26
VAL A 169
ALA A 176
TYR A 174
 None
 0.73A 6cduD-1a76A:
0.0
6cduE-1a76A:
0.0		 6cduD-1a76A:
20.45
6cduE-1a76A:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aq0 1,3-1,4-BETA-GLUCANA
SE

(Hordeum vulgare) 		PF00332
(Glyco_hydro_17) 		4 GLN A 129
ALA A 217
THR A 216
TYR A 215
 None
 0.54A 6cduD-1aq0A:
0.0
6cduE-1aq0A:
0.0		 6cduD-1aq0A:
22.25
6cduE-1aq0A:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1awb MYO-INOSITOL
MONOPHOSPHATASE

(Homo sapiens) 		PF00459
(Inositol_P) 		4 GLN A 147
ALA A 133
THR A 132
TYR A 131
 None
 0.92A 6cduD-1awbA:
0.0
6cduE-1awbA:
0.0		 6cduD-1awbA:
22.71
6cduE-1awbA:
22.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b8h DNA POLYMERASE
PROCESSIVITY
COMPONENT

(Escherichia
virus RB69) 		PF02916
(DNA_PPF)
PF09116
(gp45-slide_C) 		4 GLN A 213
VAL A 214
ALA A  40
THR A  31
 None
 0.87A 6cduD-1b8hA:
0.0
6cduE-1b8hA:
undetectable		 6cduD-1b8hA:
21.39
6cduE-1b8hA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c3l SUBTILISIN-CARLSBERG

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		4 ILE A 107
PRO A 168
ALA A 114
THR A 115
 None
 0.90A 6cduD-1c3lA:
0.0
6cduE-1c3lA:
0.0		 6cduD-1c3lA:
25.21
6cduE-1c3lA:
25.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cj2 PROTEIN
(P-HYDROXYBENZOATE
HYDROXYLASE)

(Pseudomonas
fluorescens) 		PF01494
(FAD_binding_3) 		4 ILE A  26
GLN A   4
VAL A   5
ALA A 156
 None
 0.87A 6cduD-1cj2A:
undetectable
6cduE-1cj2A:
0.0		 6cduD-1cj2A:
22.52
6cduE-1cj2A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dnv GALLERIA MELLONELLA
DENSOVIRUS CAPSID
PROTEIN

(Lepidopteran
ambidensovirus
1) 		PF02336
(Denso_VP4) 		4 ILE A 182
GLN A  87
ALA A 195
THR A 194
 None
 0.69A 6cduD-1dnvA:
0.0
6cduE-1dnvA:
0.0		 6cduD-1dnvA:
22.64
6cduE-1dnvA:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4o MALTODEXTRIN
PHOSPHORYLASE

(Escherichia
coli) 		PF00343
(Phosphorylase) 		4 ILE A  70
VAL A 206
ALA A 127
THR A 128
 None
 0.88A 6cduD-1e4oA:
1.8
6cduE-1e4oA:
1.8		 6cduD-1e4oA:
18.06
6cduE-1e4oA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ego GLUTAREDOXIN

(Escherichia
coli) 		PF00462
(Glutaredoxin) 		4 ILE A  38
VAL A  36
THR A   3
TYR A  33
 None
 0.77A 6cduD-1egoA:
0.0
6cduE-1egoA:
0.0		 6cduD-1egoA:
13.08
6cduE-1egoA:
13.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ehy PROTEIN (SOLUBLE
EPOXIDE HYDROLASE)

(Agrobacterium
tumefaciens) 		PF00561
(Abhydrolase_1) 		5 ILE A 117
VAL A 103
PRO A 237
THR A  31
TYR A  56
 None
 1.48A 6cduD-1ehyA:
undetectable
6cduE-1ehyA:
undetectable		 6cduD-1ehyA:
23.02
6cduE-1ehyA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ekb ENTEROPEPTIDASE

(Bos taurus) 		PF00089
(Trypsin) 		4 GLN B 156
VAL B  17
ALA B 221
TYR B 184
 None
 0.89A 6cduD-1ekbB:
undetectable
6cduE-1ekbB:
undetectable		 6cduD-1ekbB:
19.24
6cduE-1ekbB:
19.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hp1 5'-NUCLEOTIDASE

(Escherichia
coli) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 ILE A 165
VAL A 167
PRO A 209
ALA A 215
THR A 216
 None
 1.32A 6cduD-1hp1A:
undetectable
6cduE-1hp1A:
undetectable		 6cduD-1hp1A:
22.20
6cduE-1hp1A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hp1 5'-NUCLEOTIDASE

(Escherichia
coli) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		5 ILE A 211
VAL A 167
PRO A 209
ALA A 215
THR A 216
 None
 1.28A 6cduD-1hp1A:
undetectable
6cduE-1hp1A:
undetectable		 6cduD-1hp1A:
22.20
6cduE-1hp1A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jq4 METHANE
MONOOXYGENASE
COMPONENT C

(Methylococcus
capsulatus) 		PF00111
(Fer2) 		4 ILE A  92
PRO A  95
ALA A  30
THR A  29
 None
 0.92A 6cduD-1jq4A:
undetectable
6cduE-1jq4A:
undetectable		 6cduD-1jq4A:
14.15
6cduE-1jq4A:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kk0 EIF2GAMMA

(Pyrococcus
abyssi) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF09173
(eIF2_C) 		4 ILE A 198
VAL A  85
ALA A  55
THR A  31
 None
 0.91A 6cduD-1kk0A:
undetectable
6cduE-1kk0A:
undetectable		 6cduD-1kk0A:
21.28
6cduE-1kk0A:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE

(Lactococcus
lactis) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C)
PF09168
(PepX_N) 		4 ILE A 462
VAL A 460
ALA A 358
THR A 359
 None
 0.91A 6cduD-1lnsA:
undetectable
6cduE-1lnsA:
undetectable		 6cduD-1lnsA:
17.91
6cduE-1lnsA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mbq TRYPSIN

(Oncorhynchus
keta) 		PF00089
(Trypsin) 		4 GLN A 156
VAL A  17
ALA A 221
TYR A1184
 None
 0.92A 6cduD-1mbqA:
undetectable
6cduE-1mbqA:
undetectable		 6cduD-1mbqA:
20.72
6cduE-1mbqA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o94 TRIMETHYLAMINE
DEHYDROGENASE

(Methylophilus
methylotrophus) 		PF00724
(Oxidored_FMN)
PF07992
(Pyr_redox_2) 		4 VAL A 166
PRO A  28
ALA A 155
TYR A 151
 None
FMN  A1730 (-4.8A)
None
None
 0.91A 6cduD-1o94A:
undetectable
6cduE-1o94A:
undetectable		 6cduD-1o94A:
17.78
6cduE-1o94A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1omo ALANINE
DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF02423
(OCD_Mu_crystall) 		4 GLN A 296
ALA A 101
THR A 102
TYR A 103
 GLN  A 296 ( 0.6A)
ALA  A 101 ( 0.0A)
THR  A 102 ( 0.8A)
TYR  A 103 ( 1.3A)
 0.74A 6cduD-1omoA:
undetectable
6cduE-1omoA:
undetectable		 6cduD-1omoA:
22.70
6cduE-1omoA:
22.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p4m RIBOFLAVIN KINASE

(Homo sapiens) 		PF01687
(Flavokinase) 		5 ILE A 101
GLN A  18
VAL A  19
ALA A  35
THR A  87
 None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.0A)
None
 1.19A 6cduD-1p4mA:
undetectable
6cduE-1p4mA:
undetectable		 6cduD-1p4mA:
18.09
6cduE-1p4mA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rhi HUMAN RHINOVIRUS 3
COAT PROTEIN

(Rhinovirus B) 		PF00073
(Rhv) 		5 ILE 2  58
PRO 2  56
ALA 2 245
THR 2 107
TYR 2 106
 None
 1.37A 6cduD-1rhi2:
undetectable
6cduE-1rhi2:
undetectable		 6cduD-1rhi2:
19.51
6cduE-1rhi2:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ro5 AUTOINDUCER
SYNTHESIS PROTEIN
LASI

(Pseudomonas
aeruginosa) 		PF00765
(Autoind_synth) 		4 GLN A  57
VAL A   3
ALA A 127
TYR A 131
 None
 0.90A 6cduD-1ro5A:
undetectable
6cduE-1ro5A:
undetectable		 6cduD-1ro5A:
22.99
6cduE-1ro5A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sq5 PANTOTHENATE KINASE

(Escherichia
coli) 		PF00485
(PRK) 		5 ILE A1290
GLN A1205
VAL A1203
PRO A1148
THR A1125
 None
 1.38A 6cduD-1sq5A:
undetectable
6cduE-1sq5A:
undetectable		 6cduD-1sq5A:
21.85
6cduE-1sq5A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tt7 YHFP

(Bacillus
subtilis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 VAL A 168
PRO A 294
ALA A 159
THR A 160
 None
 0.92A 6cduD-1tt7A:
undetectable
6cduE-1tt7A:
undetectable		 6cduD-1tt7A:
23.81
6cduE-1tt7A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbf 231AA LONG
HYPOTHETICAL
PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Sulfurisphaera
tokodaii) 		PF01135
(PCMT) 		4 PRO A  30
ALA A  86
THR A  85
TYR A  84
 None
 0.84A 6cduD-1vbfA:
undetectable
6cduE-1vbfA:
undetectable		 6cduD-1vbfA:
21.47
6cduE-1vbfA:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w25 STALKED-CELL
DIFFERENTIATION
CONTROLLING PROTEIN

(Caulobacter
vibrioides) 		PF00072
(Response_reg)
PF00990
(GGDEF) 		4 ILE A 375
VAL A 321
ALA A 314
THR A 315
 None
 0.79A 6cduD-1w25A:
undetectable
6cduE-1w25A:
undetectable		 6cduD-1w25A:
21.94
6cduE-1w25A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8o BACTERIAL SIALIDASE

(Micromonospora
viridifaciens) 		PF00754
(F5_F8_type_C)
PF10633
(NPCBM_assoc)
PF13088
(BNR_2) 		4 GLN A 115
VAL A 117
ALA A 175
THR A 176
 None
 0.90A 6cduD-1w8oA:
3.1
6cduE-1w8oA:
undetectable		 6cduD-1w8oA:
21.89
6cduE-1w8oA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyn CALPONIN-2

(Homo sapiens) 		PF00307
(CH) 		4 ILE A  63
VAL A  60
ALA A  82
TYR A  86
 None
 0.84A 6cduD-1wynA:
undetectable
6cduE-1wynA:
undetectable		 6cduD-1wynA:
18.21
6cduE-1wynA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xa6 BETA2-CHIMAERIN

(Homo sapiens) 		PF00017
(SH2)
PF00130
(C1_1)
PF00620
(RhoGAP) 		4 ILE A  42
PRO A  44
THR A  91
TYR A  90
 None
 0.86A 6cduD-1xa6A:
undetectable
6cduE-1xa6A:
1.7		 6cduD-1xa6A:
20.21
6cduE-1xa6A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xa6 BETA2-CHIMAERIN

(Homo sapiens) 		PF00017
(SH2)
PF00130
(C1_1)
PF00620
(RhoGAP) 		4 ILE A 335
VAL A 322
ALA A 349
TYR A 353
 None
 0.81A 6cduD-1xa6A:
undetectable
6cduE-1xa6A:
1.7		 6cduD-1xa6A:
20.21
6cduE-1xa6A:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8l GLUTAMATE
CARBOXYPEPTIDASE II

(Homo sapiens) 		PF02225
(PA)
PF04253
(TFR_dimer)
PF04389
(Peptidase_M28) 		5 ILE A 292
GLN A 218
PRO A 290
ALA A 203
TYR A 205
 None
 1.46A 6cduD-1z8lA:
3.3
6cduE-1z8lA:
1.7		 6cduD-1z8lA:
20.58
6cduE-1z8lA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlr COAGULATION FACTOR
XI

(Homo sapiens) 		PF00089
(Trypsin) 		4 GLN A 156
VAL A  17
ALA A 220
TYR A 184
 None
 0.89A 6cduD-1zlrA:
undetectable
6cduE-1zlrA:
undetectable		 6cduD-1zlrA:
19.75
6cduE-1zlrA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zq1 GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D

(Pyrococcus
abyssi) 		PF00710
(Asparaginase) 		4 VAL A 254
ALA A 185
THR A 184
TYR A 183
 None
 0.85A 6cduD-1zq1A:
undetectable
6cduE-1zq1A:
undetectable		 6cduD-1zq1A:
22.05
6cduE-1zq1A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2axc COLICIN E7

(Escherichia
coli) 		PF03515
(Cloacin) 		4 ILE A 191
GLN A 189
VAL A 183
ALA A 254
 None
 0.90A 6cduD-2axcA:
undetectable
6cduE-2axcA:
undetectable		 6cduD-2axcA:
20.53
6cduE-2axcA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bas YKUI PROTEIN

(Bacillus
subtilis) 		PF00563
(EAL)
PF10388
(YkuI_C) 		5 ILE A 334
GLN A 336
VAL A 326
ALA A 302
THR A 306
 None
 1.29A 6cduD-2basA:
undetectable
6cduE-2basA:
undetectable		 6cduD-2basA:
21.62
6cduE-2basA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dby GTP-BINDING PROTEIN

(Thermus
thermophilus) 		PF01926
(MMR_HSR1)
PF06071
(YchF-GTPase_C) 		4 ILE A   6
VAL A   4
ALA A 281
TYR A 279
 None
 0.82A 6cduD-2dbyA:
1.8
6cduE-2dbyA:
1.8		 6cduD-2dbyA:
21.78
6cduE-2dbyA:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpp NITRILE HYDRATASE
BETA SUBUNIT

(Bacillus sp.
RAPc8) 		PF02211
(NHase_beta) 		4 ILE B   4
ALA B  78
THR B  79
TYR B  82
 None
 0.91A 6cduD-2dppB:
undetectable
6cduE-2dppB:
undetectable		 6cduD-2dppB:
20.85
6cduE-2dppB:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eek TRYPSIN-1

(Gadus morhua) 		PF00089
(Trypsin) 		4 GLN A 156
VAL A  17
ALA A 221
TYR A 184
 None
 0.90A 6cduD-2eekA:
undetectable
6cduE-2eekA:
undetectable		 6cduD-2eekA:
18.45
6cduE-2eekA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fo1 LIN-12 PROTEIN

(Caenorhabditis
elegans) 		PF00023
(Ank)
PF12796
(Ank_2) 		4 ILE E1048
VAL E1056
TRP E1059
ALA E1030
 None
 0.83A 6cduD-2fo1E:
undetectable
6cduE-2fo1E:
undetectable		 6cduD-2fo1E:
22.58
6cduE-2fo1E:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g0b FEEM

(uncultured
bacterium) 		no annotation 5 GLN A 183
VAL A 177
TRP A 180
ALA A 129
THR A 127
 None
 1.49A 6cduD-2g0bA:
undetectable
6cduE-2g0bA:
undetectable		 6cduD-2g0bA:
20.61
6cduE-2g0bA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gep SULFITE REDUCTASE
HEMOPROTEIN

(Escherichia
coli) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 ILE A 177
VAL A 220
ALA A 239
TYR A 337
 None
 0.89A 6cduD-2gepA:
undetectable
6cduE-2gepA:
undetectable		 6cduD-2gepA:
20.80
6cduE-2gepA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hms YUAA PROTEIN

(Bacillus
subtilis) 		PF02254
(TrkA_N) 		4 ILE A  75
VAL A  22
ALA A  49
THR A  50
 None
 0.75A 6cduD-2hmsA:
undetectable
6cduE-2hmsA:
undetectable		 6cduD-2hmsA:
16.98
6cduE-2hmsA:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ime 2-HYDROXYCHROMENE-2-
CARBOXYLATE
ISOMERASE

(Pseudomonas
putida) 		PF01323
(DSBA) 		4 PRO A 126
ALA A 149
THR A 150
TYR A 153
 None
 0.90A 6cduD-2imeA:
undetectable
6cduE-2imeA:
undetectable		 6cduD-2imeA:
20.31
6cduE-2imeA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jad YELLOW FLUORESCENT
PROTEIN GLUTAREDOXIN
FUSION PROTEIN

(Saccharomyces
cerevisiae;
Aequorea
victoria) 		PF00462
(Glutaredoxin)
PF01353
(GFP) 		4 ILE A 136
GLN A 177
THR A  97
TYR A 182
 None
 0.81A 6cduD-2jadA:
undetectable
6cduE-2jadA:
undetectable		 6cduD-2jadA:
21.27
6cduE-2jadA:
21.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jg5 FRUCTOSE 1-PHOSPHATE
KINASE

(Staphylococcus
aureus) 		PF00294
(PfkB) 		4 ILE A 294
GLN A 297
VAL A 298
ALA A 234
 None
 0.61A 6cduD-2jg5A:
undetectable
6cduE-2jg5A:
undetectable		 6cduD-2jg5A:
22.73
6cduE-2jg5A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k2q SURFACTIN SYNTHETASE
THIOESTERASE SUBUNIT

(Bacillus
subtilis) 		PF00975
(Thioesterase) 		4 VAL B 152
PRO B 116
ALA B 166
TYR B 164
 None
 0.91A 6cduD-2k2qB:
undetectable
6cduE-2k2qB:
undetectable		 6cduD-2k2qB:
20.18
6cduE-2k2qB:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l3s AUTOINHIBITED CRK
PROTEIN

(Gallus gallus) 		PF00018
(SH3_1)
PF07653
(SH3_2) 		4 ILE A 270
VAL A 267
ALA A 241
TYR A 240
 None
 0.86A 6cduD-2l3sA:
undetectable
6cduE-2l3sA:
undetectable		 6cduD-2l3sA:
20.06
6cduE-2l3sA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzu CATABOLITE CONTROL
PROTEIN

(Bacillus
megaterium) 		PF13377
(Peripla_BP_3) 		4 ILE G  94
VAL G  63
ALA G  86
THR G  87
 None
 0.92A 6cduD-2nzuG:
undetectable
6cduE-2nzuG:
undetectable		 6cduD-2nzuG:
20.76
6cduE-2nzuG:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		4 ILE A 256
VAL A 174
ALA A 188
THR A 187
 None
 0.74A 6cduD-2okcA:
undetectable
6cduE-2okcA:
undetectable		 6cduD-2okcA:
19.91
6cduE-2okcA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2owp HYPOTHETICAL PROTEIN
BXE_B1374

(Paraburkholderia
xenovorans) 		PF11533
(DUF3225) 		4 ILE A   8
GLN A  11
VAL A  12
THR A 105
 None
 0.75A 6cduD-2owpA:
undetectable
6cduE-2owpA:
undetectable		 6cduD-2owpA:
17.53
6cduE-2owpA:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9g CYTOCHROME P450 46A1

(Homo sapiens) 		PF00067
(p450) 		4 PRO A 478
ALA A 188
THR A 187
TYR A 186
 None
None
None
GOL  A 601 ( 4.5A)
 0.72A 6cduD-2q9gA:
1.1
6cduE-2q9gA:
1.1		 6cduD-2q9gA:
23.11
6cduE-2q9gA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rez MULTIFUNCTIONAL
CYCLASE-DEHYDRATASE-
3-O-METHYL
TRANSFERASE TCMN

(Streptomyces
glaucescens) 		PF03364
(Polyketide_cyc) 		5 GLN A 110
VAL A 109
TRP A  95
THR A  77
TYR A  97
 None
 1.41A 6cduD-2rezA:
undetectable
6cduE-2rezA:
undetectable		 6cduD-2rezA:
19.75
6cduE-2rezA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLN A 342
ALA A 180
THR A 179
TYR A 178
 None
 0.85A 6cduD-2v55A:
undetectable
6cduE-2v55A:
undetectable		 6cduD-2v55A:
20.82
6cduE-2v55A:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vn7 GLUCOAMYLASE

(Trichoderma
reesei) 		PF00686
(CBM_20)
PF00723
(Glyco_hydro_15) 		4 GLN A 356
VAL A 359
ALA A 380
TYR A 384
 None
 0.90A 6cduD-2vn7A:
1.8
6cduE-2vn7A:
2.0		 6cduD-2vn7A:
20.17
6cduE-2vn7A:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2waa XYLAN ESTERASE,
PUTATIVE, AXE2C

(Cellvibrio
japonicus) 		PF13472
(Lipase_GDSL_2) 		5 ILE A 135
VAL A 137
PRO A 226
ALA A 232
THR A 271
 None
 1.39A 6cduD-2waaA:
undetectable
6cduE-2waaA:
undetectable		 6cduD-2waaA:
19.45
6cduE-2waaA:
19.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wvg PYRUVATE
DECARBOXYLASE

(Zymomonas
mobilis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 VAL A  14
ALA A  10
THR A   7
TYR A   8
 None
 0.87A 6cduD-2wvgA:
undetectable
6cduE-2wvgA:
undetectable		 6cduD-2wvgA:
18.36
6cduE-2wvgA:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x3h K5 LYASE

(Escherichia
virus K1-5) 		no annotation 4 ILE A 165
VAL A 181
ALA A 183
TYR A 151
 None
 0.90A 6cduD-2x3hA:
undetectable
6cduE-2x3hA:
undetectable		 6cduD-2x3hA:
20.89
6cduE-2x3hA:
20.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y2w ARABINOFURANOSIDASE

(Bifidobacterium
longum) 		PF06964
(Alpha-L-AF_C) 		4 VAL A 386
ALA A 382
THR A 381
TYR A 380
 None
 0.87A 6cduD-2y2wA:
undetectable
6cduE-2y2wA:
undetectable		 6cduD-2y2wA:
19.38
6cduE-2y2wA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxm MYOSIN-BINDING
PROTEIN C, SLOW-TYPE

(Homo sapiens) 		PF07679
(I-set) 		4 ILE A  64
GLN A  62
VAL A  30
THR A  89
 None
 0.84A 6cduD-2yxmA:
undetectable
6cduE-2yxmA:
undetectable		 6cduD-2yxmA:
14.80
6cduE-2yxmA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zc4 PENICILLIN-BINDING
PROTEIN 2X

(Streptococcus
pneumoniae) 		PF03793
(PASTA) 		4 GLN C 728
VAL C 727
ALA C 707
THR C 706
 None
 0.89A 6cduD-2zc4C:
undetectable
6cduE-2zc4C:
undetectable		 6cduD-2zc4C:
17.85
6cduE-2zc4C:
17.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zqp PREPROTEIN
TRANSLOCASE SECY
SUBUNIT

(Thermus
thermophilus) 		PF00344
(SecY) 		4 VAL Y 329
PRO Y 333
THR Y 323
TYR Y 324
 None
 0.92A 6cduD-2zqpY:
undetectable
6cduE-2zqpY:
undetectable		 6cduD-2zqpY:
19.30
6cduE-2zqpY:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ab4 ASPARTOKINASE

(Corynebacterium
glutamicum) 		PF00696
(AA_kinase)
PF01842
(ACT)
PF13840
(ACT_7) 		4 VAL A 187
ALA A 182
THR A 181
TYR A 180
 None
 0.82A 6cduD-3ab4A:
undetectable
6cduE-3ab4A:
undetectable		 6cduD-3ab4A:
21.40
6cduE-3ab4A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ai5 YEAST ENHANCED GREEN
FLUORESCENT
PROTEIN,UBIQUITIN

(Aequorea
victoria;
Mus musculus) 		PF00240
(ubiquitin)
PF01353
(GFP) 		4 ILE A 136
GLN A 177
THR A  97
TYR A 182
 None
None
EDO  A 317 (-3.8A)
None
 0.86A 6cduD-3ai5A:
undetectable
6cduE-3ai5A:
undetectable		 6cduD-3ai5A:
20.80
6cduE-3ai5A:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak4 NADH-DEPENDENT
QUINUCLIDINONE
REDUCTASE

(Agrobacterium
tumefaciens) 		PF13561
(adh_short_C2) 		4 ILE A  78
GLN A  75
ALA A  39
THR A  15
 None
 0.91A 6cduD-3ak4A:
undetectable
6cduE-3ak4A:
undetectable		 6cduD-3ak4A:
21.26
6cduE-3ak4A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ako VENUS
VENUS

(Plant
transformation
vector
pSITEII-4C1;
Plant
transformation
vector
pSITEII-4C1) 		PF01353
(GFP)
PF01353
(GFP) 		4 ILE A 136
GLN B 177
THR A  97
TYR B 182
 None
 0.88A 6cduD-3akoA:
undetectable
6cduE-3akoA:
undetectable		 6cduD-3akoA:
19.40
6cduE-3akoA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ayf NITRIC OXIDE
REDUCTASE

(Geobacillus
stearothermophilus) 		PF00115
(COX1) 		4 GLN A 712
ALA A 100
THR A  99
TYR A  98
 None
 0.66A 6cduD-3ayfA:
5.2
6cduE-3ayfA:
5.1		 6cduD-3ayfA:
18.31
6cduE-3ayfA:
18.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bge PREDICTED ATPASE

(Haemophilus
influenzae) 		PF12002
(MgsA_C) 		5 ILE A 426
PRO A 307
ALA A 351
THR A 350
TYR A 349
 None
 1.45A 6cduD-3bgeA:
undetectable
6cduE-3bgeA:
undetectable		 6cduD-3bgeA:
20.06
6cduE-3bgeA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dao PUTATIVE PHOSPHATE

([Eubacterium]
rectale) 		PF08282
(Hydrolase_3) 		5 ILE A  77
VAL A  71
PRO A 109
ALA A 196
THR A 195
 None
 1.44A 6cduD-3daoA:
undetectable
6cduE-3daoA:
undetectable		 6cduD-3daoA:
20.47
6cduE-3daoA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm0 MALTOSE-BINDING
PERIPLASMIC PROTEIN
FUSED WITH RACK1

(Escherichia
coli;
Arabidopsis
thaliana) 		PF00400
(WD40)
PF01547
(SBP_bac_1) 		4 GLN A1056
VAL A1054
ALA A1051
TYR A1052
 None
 0.85A 6cduD-3dm0A:
undetectable
6cduE-3dm0A:
undetectable		 6cduD-3dm0A:
18.16
6cduE-3dm0A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e49 UNCHARACTERIZED
PROTEIN DUF849 WITH
A TIM BARREL FOLD

(Paraburkholderia
xenovorans) 		PF05853
(BKACE) 		5 GLN A 197
VAL A 196
TRP A 230
ALA A 220
THR A 219
 None
 1.34A 6cduD-3e49A:
undetectable
6cduE-3e49A:
undetectable		 6cduD-3e49A:
23.36
6cduE-3e49A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ec7 PUTATIVE
DEHYDROGENASE

(Salmonella
enterica) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ILE A  62
VAL A  82
ALA A  74
THR A  73
 None
None
NAD  A 400 (-3.8A)
None
 0.82A 6cduD-3ec7A:
undetectable
6cduE-3ec7A:
undetectable		 6cduD-3ec7A:
20.53
6cduE-3ec7A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eq1 PORPHOBILINOGEN
DEAMINASE

(Homo sapiens) 		PF01379
(Porphobil_deam)
PF03900
(Porphobil_deamC) 		4 ILE A 248
GLN A 332
ALA A 297
THR A 298
 None
 0.92A 6cduD-3eq1A:
undetectable
6cduE-3eq1A:
undetectable		 6cduD-3eq1A:
23.28
6cduE-3eq1A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqn GLUCAN
1,3-BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF12708
(Pectate_lyase_3) 		4 ILE A 674
VAL A 676
ALA A 630
THR A 607
 None
 0.90A 6cduD-3eqnA:
undetectable
6cduE-3eqnA:
undetectable		 6cduD-3eqnA:
17.63
6cduE-3eqnA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evp GREEN FLUORESCENT
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Aequorea
victoria) 		PF01353
(GFP) 		4 ILE A 294
GLN A  90
THR A 255
TYR A  95
 None
 0.85A 6cduD-3evpA:
undetectable
6cduE-3evpA:
undetectable		 6cduD-3evpA:
21.36
6cduE-3evpA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3evr MYOSIN LIGHT CHAIN
KINASE, GREEN
FLUORESCENT PROTEIN,
CALMODULIN-1 CHIMERA

(Aequorea
victoria;
Rattus
norvegicus) 		PF01353
(GFP)
PF13499
(EF-hand_7) 		4 ILE A 294
GLN A  90
THR A 255
TYR A  95
 None
 0.87A 6cduD-3evrA:
undetectable
6cduE-3evrA:
undetectable		 6cduD-3evrA:
21.68
6cduE-3evrA:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fbu ACETYLTRANSFERASE,
GNAT FAMILY

(Bacillus
anthracis) 		PF13302
(Acetyltransf_3) 		4 ILE A  64
ALA A 106
THR A 107
TYR A 110
 None
 0.83A 6cduD-3fbuA:
undetectable
6cduE-3fbuA:
undetectable		 6cduD-3fbuA:
17.99
6cduE-3fbuA:
17.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsn RETINAL PIGMENT
EPITHELIUM-SPECIFIC
65 KDA PROTEIN

(Bos taurus) 		PF03055
(RPE65) 		4 ILE A 225
VAL A 174
ALA A 177
THR A 178
 None
 0.81A 6cduD-3fsnA:
undetectable
6cduE-3fsnA:
undetectable		 6cduD-3fsnA:
19.67
6cduE-3fsnA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fw6 CELLULASE

(uncultured
bacterium) 		PF12891
(Glyco_hydro_44) 		5 GLN A 512
VAL A 541
PRO A 537
ALA A 409
THR A 407
 None
 1.38A 6cduD-3fw6A:
undetectable
6cduE-3fw6A:
undetectable		 6cduD-3fw6A:
22.84
6cduE-3fw6A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g5l PUTATIVE
S-ADENOSYLMETHIONINE
DEPENDENT
METHYLTRANSFERASE

(Listeria
monocytogenes) 		PF13649
(Methyltransf_25) 		4 VAL A 169
TRP A 167
ALA A 150
THR A 149
 None
 0.88A 6cduD-3g5lA:
undetectable
6cduE-3g5lA:
undetectable		 6cduD-3g5lA:
18.98
6cduE-3g5lA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3go7 RIBOKINASE RBSK

(Mycobacterium
tuberculosis) 		PF00294
(PfkB) 		4 GLN A  56
VAL A 243
ALA A 276
THR A 277
 None
 0.89A 6cduD-3go7A:
undetectable
6cduE-3go7A:
undetectable		 6cduD-3go7A:
21.45
6cduE-3go7A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gyb TRANSCRIPTIONAL
REGULATORS
(LACI-FAMILY
TRANSCRIPTIONAL
REGULATORY PROTEIN)

(Corynebacterium
glutamicum) 		PF13377
(Peripla_BP_3) 		4 ILE A  66
VAL A  68
PRO A 119
ALA A 125
 None
 0.85A 6cduD-3gybA:
undetectable
6cduE-3gybA:
undetectable		 6cduD-3gybA:
21.66
6cduE-3gybA:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzg MOLYBDATE-BINDING
PERIPLASMIC PROTEIN
PERMEASE

(Xanthomonas
citri) 		PF13531
(SBP_bac_11) 		4 ILE A 168
VAL A  88
PRO A  99
ALA A 174
 None
 0.87A 6cduD-3gzgA:
undetectable
6cduE-3gzgA:
undetectable		 6cduD-3gzgA:
19.35
6cduE-3gzgA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h8l NADH OXIDASE

(Acidianus
ambivalens) 		PF07992
(Pyr_redox_2) 		4 ILE A 109
ALA A  16
THR A  15
TYR A  18
 FAD  A1001 (-3.7A)
None
None
None
 0.88A 6cduD-3h8lA:
undetectable
6cduE-3h8lA:
undetectable		 6cduD-3h8lA:
23.11
6cduE-3h8lA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i1i HOMOSERINE
O-ACETYLTRANSFERASE

(Bacillus
anthracis) 		PF00561
(Abhydrolase_1) 		5 ILE A 269
PRO A 213
ALA A 281
THR A 280
TYR A 279
 None
 1.42A 6cduD-3i1iA:
undetectable
6cduE-3i1iA:
undetectable		 6cduD-3i1iA:
22.60
6cduE-3i1iA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i27 HEMAGGLUTININ-ESTERA
SE

(Bovine
torovirus) 		PF02710
(Hema_HEFG)
PF03996
(Hema_esterase) 		5 ILE A 310
GLN A 284
VAL A 283
ALA A 131
THR A 133
 None
 1.39A 6cduD-3i27A:
undetectable
6cduE-3i27A:
undetectable		 6cduD-3i27A:
21.86
6cduE-3i27A:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j23 CAPSID PROTEIN VP1
CAPSID PROTEIN VP3

(Enterovirus A;
Enterovirus A) 		PF00073
(Rhv)
PF00073
(Rhv) 		4 ILE A 294
VAL C  55
PRO C  59
ALA C 216
 None
 0.89A 6cduD-3j23A:
undetectable
6cduE-3j23A:
undetectable		 6cduD-3j23A:
19.64
6cduE-3j23A:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF11

(Schizosaccharomyces
pombe) 		PF13087
(AAA_12)
PF16399
(Aquarius_N) 		4 ILE X 366
PRO X 361
ALA X 254
THR X 253
 None
 0.89A 6cduD-3jb9X:
undetectable
6cduE-3jb9X:
undetectable		 6cduD-3jb9X:
13.72
6cduE-3jb9X:
13.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd5 28S RIBOSOMAL
PROTEIN S11,
MITOCHONDRIAL

(Bos taurus) 		PF00411
(Ribosomal_S11) 		4 ILE K 100
VAL K 102
ALA K 142
THR K 143
 None
 0.90A 6cduD-3jd5K:
undetectable
6cduE-3jd5K:
undetectable		 6cduD-3jd5K:
20.62
6cduE-3jd5K:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd5 28S RIBOSOMAL
PROTEIN S17,
MITOCHONDRIAL

(Bos taurus) 		PF00366
(Ribosomal_S17) 		4 ILE Q  13
VAL Q  28
ALA Q  26
THR Q  25
 None
None
None
C  A 120 ( 3.3A)
 0.78A 6cduD-3jd5Q:
undetectable
6cduE-3jd5Q:
undetectable		 6cduD-3jd5Q:
17.65
6cduE-3jd5Q:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ke6 PROTEIN
RV1364C/MT1410

(Mycobacterium
tuberculosis) 		PF07228
(SpoIIE)
PF13581
(HATPase_c_2) 		4 ILE A 428
VAL A 474
PRO A 174
ALA A 476
 None
 0.80A 6cduD-3ke6A:
2.5
6cduE-3ke6A:
2.5		 6cduD-3ke6A:
21.21
6cduE-3ke6A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mcs PUTATIVE
MONOOXYGENASE

(Fusobacterium
nucleatum) 		PF03992
(ABM) 		4 VAL A  82
ALA A  25
THR A  26
TYR A  29
 None
 0.67A 6cduD-3mcsA:
undetectable
6cduE-3mcsA:
undetectable		 6cduD-3mcsA:
21.45
6cduE-3mcsA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmt FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Bartonella
henselae) 		PF00274
(Glycolytic) 		4 ILE A 221
VAL A 257
TRP A 287
THR A 252
 None
 0.79A 6cduD-3mmtA:
undetectable
6cduE-3mmtA:
undetectable		 6cduD-3mmtA:
20.00
6cduE-3mmtA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ng0 GLUTAMINE SYNTHETASE

(Synechocystis
sp. PCC 6803) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		4 GLN A   6
VAL A   8
ALA A  77
THR A  76
 None
 0.72A 6cduD-3ng0A:
undetectable
6cduE-3ng0A:
undetectable		 6cduD-3ng0A:
21.15
6cduE-3ng0A:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Escherichia
coli;
Aequorea
victoria) 		PF01353
(GFP)
PF01547
(SBP_bac_1)
PF13416
(SBP_bac_8) 		4 ILE A 410
GLN A 206
THR A 371
TYR A 211
 None
 0.85A 6cduD-3osqA:
undetectable
6cduE-3osqA:
undetectable		 6cduD-3osqA:
18.83
6cduE-3osqA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osr MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Escherichia
coli;
Aequorea
victoria) 		PF01353
(GFP)
PF01547
(SBP_bac_1) 		4 ILE A 548
GLN A 344
THR A 509
TYR A 349
 None
 0.87A 6cduD-3osrA:
undetectable
6cduE-3osrA:
undetectable		 6cduD-3osrA:
19.61
6cduE-3osrA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3owa ACYL-COA
DEHYDROGENASE

(Bacillus
anthracis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 VAL A 322
ALA A 318
THR A 315
TYR A 316
 None
 0.85A 6cduD-3owaA:
3.7
6cduE-3owaA:
3.6		 6cduD-3owaA:
20.07
6cduE-3owaA:
20.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1w RABGDI PROTEIN

(Plasmodium
falciparum) 		PF00996
(GDI) 		4 ILE A 333
GLN A 331
ALA A 368
THR A 369
 None
 0.74A 6cduD-3p1wA:
undetectable
6cduE-3p1wA:
undetectable		 6cduD-3p1wA:
21.44
6cduE-3p1wA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pco PHENYLALANYL-TRNA
SYNTHETASE, ALPHA
SUBUNIT
PHENYLALANYL-TRNA
SYNTHETASE, BETA
CHAIN

(Escherichia
coli;
Escherichia
coli) 		PF01409
(tRNA-synt_2d)
PF02912
(Phe_tRNA-synt_N)
PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		4 PRO A 204
ALA B 554
THR B 555
TYR B 558
 None
 0.86A 6cduD-3pcoA:
undetectable
6cduE-3pcoA:
undetectable		 6cduD-3pcoA:
21.61
6cduE-3pcoA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3puk SYNTAXIN-BINDING
PROTEIN 3

(Mus musculus) 		PF00995
(Sec1) 		4 ILE A 567
GLN A 143
VAL A 147
ALA A 548
 None
 0.79A 6cduD-3pukA:
undetectable
6cduE-3pukA:
undetectable		 6cduD-3pukA:
19.77
6cduE-3pukA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q41 GLUTAMATE [NMDA]
RECEPTOR SUBUNIT
ZETA-1

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 VAL A 118
ALA A 111
THR A 110
TYR A 109
 None
 0.89A 6cduD-3q41A:
undetectable
6cduE-3q41A:
undetectable		 6cduD-3q41A:
20.71
6cduE-3q41A:
20.71