SIMILAR PATTERNS OF AMINO ACIDS FOR 6CDU_D_EY4D500_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxz NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ILE A 240
VAL A 183
ALA A 212
THR A 213
 None
 0.96A 6cduC-1bxzA:
undetectable
6cduD-1bxzA:
undetectable		 6cduC-1bxzA:
21.04
6cduD-1bxzA:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cj2 PROTEIN
(P-HYDROXYBENZOATE
HYDROXYLASE)

(Pseudomonas
fluorescens) 		PF01494
(FAD_binding_3) 		4 ILE A  26
GLN A   4
VAL A   5
ALA A 156
 None
 0.88A 6cduC-1cj2A:
undetectable
6cduD-1cj2A:
undetectable		 6cduC-1cj2A:
22.52
6cduD-1cj2A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e4o MALTODEXTRIN
PHOSPHORYLASE

(Escherichia
coli) 		PF00343
(Phosphorylase) 		4 ILE A  70
VAL A 206
ALA A 127
THR A 128
 None
 0.92A 6cduC-1e4oA:
undetectable
6cduD-1e4oA:
undetectable		 6cduC-1e4oA:
18.06
6cduD-1e4oA:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fnf FIBRONECTIN

(Homo sapiens) 		PF00041
(fn3) 		4 ILE A1485
VAL A1425
ALA A1428
THR A1429
 None
 0.97A 6cduC-1fnfA:
2.4
6cduD-1fnfA:
2.2		 6cduC-1fnfA:
24.34
6cduD-1fnfA:
24.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hp1 5'-NUCLEOTIDASE

(Escherichia
coli) 		PF00149
(Metallophos)
PF02872
(5_nucleotid_C) 		4 ILE A 165
VAL A 167
PRO A 209
ALA A 215
 None
 0.91A 6cduC-1hp1A:
0.0
6cduD-1hp1A:
undetectable		 6cduC-1hp1A:
22.20
6cduD-1hp1A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jq4 METHANE
MONOOXYGENASE
COMPONENT C

(Methylococcus
capsulatus) 		PF00111
(Fer2) 		4 ILE A  92
PRO A  95
ALA A  30
THR A  29
 None
 0.93A 6cduC-1jq4A:
undetectable
6cduD-1jq4A:
undetectable		 6cduC-1jq4A:
14.15
6cduD-1jq4A:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ldk CULLIN HOMOLOG

(Homo sapiens) 		PF00888
(Cullin)
PF10557
(Cullin_Nedd8) 		4 ILE B 635
GLN B 638
VAL B 639
THR B 605
 None
 0.98A 6cduC-1ldkB:
2.0
6cduD-1ldkB:
1.7		 6cduC-1ldkB:
23.21
6cduD-1ldkB:
23.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lns X-PROLYL DIPEPTIDYL
AMINOPEPTIDASE

(Lactococcus
lactis) 		PF02129
(Peptidase_S15)
PF08530
(PepX_C)
PF09168
(PepX_N) 		4 ILE A 462
VAL A 460
ALA A 358
THR A 359
 None
 0.90A 6cduC-1lnsA:
0.0
6cduD-1lnsA:
undetectable		 6cduC-1lnsA:
17.91
6cduD-1lnsA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p4m RIBOFLAVIN KINASE

(Homo sapiens) 		PF01687
(Flavokinase) 		4 ILE A 101
GLN A  18
VAL A  19
ALA A  35
 None
None
ADP  A 301 (-4.7A)
ADP  A 301 ( 4.0A)
 0.95A 6cduC-1p4mA:
undetectable
6cduD-1p4mA:
undetectable		 6cduC-1p4mA:
18.09
6cduD-1p4mA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uas ALPHA-GALACTOSIDASE

(Oryza sativa) 		PF16499
(Melibiase_2)
PF17450
(Melibiase_2_C) 		4 GLN A 271
VAL A 269
PRO A   9
ALA A 300
 GOL  A1607 (-4.1A)
None
None
None
 0.96A 6cduC-1uasA:
undetectable
6cduD-1uasA:
undetectable		 6cduC-1uasA:
20.32
6cduD-1uasA:
20.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzv HYPOTHETICAL PROTEIN

(Trypanosoma
cruzi) 		PF00857
(Isochorismatase) 		4 GLN A 104
VAL A 106
ALA A 133
THR A 164
 None
 0.96A 6cduC-1yzvA:
undetectable
6cduD-1yzvA:
undetectable		 6cduC-1yzvA:
21.36
6cduD-1yzvA:
21.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aey FRUCTAN
1-EXOHYDROLASE IIA

(Cichorium
intybus) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 ILE A 134
VAL A 108
PRO A 148
ALA A  76
 None
 0.93A 6cduC-2aeyA:
undetectable
6cduD-2aeyA:
undetectable		 6cduC-2aeyA:
21.88
6cduD-2aeyA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)

(Homo sapiens) 		PF03199
(GSH_synthase)
PF03917
(GSH_synth_ATP) 		4 ILE A 454
GLN A 421
VAL A 420
THR A  51
 None
 0.95A 6cduC-2hgsA:
undetectable
6cduD-2hgsA:
undetectable		 6cduC-2hgsA:
20.84
6cduD-2hgsA:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ht6 GTP-BINDING PROTEIN
GEM

(Homo sapiens) 		PF00071
(Ras) 		4 VAL A 236
PRO A 185
ALA A 125
THR A  74
 None
 0.99A 6cduC-2ht6A:
undetectable
6cduD-2ht6A:
undetectable		 6cduC-2ht6A:
20.85
6cduD-2ht6A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jg5 FRUCTOSE 1-PHOSPHATE
KINASE

(Staphylococcus
aureus) 		PF00294
(PfkB) 		4 ILE A 294
GLN A 297
VAL A 298
ALA A 234
 None
 0.62A 6cduC-2jg5A:
undetectable
6cduD-2jg5A:
undetectable		 6cduC-2jg5A:
22.73
6cduD-2jg5A:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzu CATABOLITE CONTROL
PROTEIN

(Bacillus
megaterium) 		PF13377
(Peripla_BP_3) 		4 ILE G  94
VAL G  63
ALA G  86
THR G  87
 None
 0.84A 6cduC-2nzuG:
undetectable
6cduD-2nzuG:
undetectable		 6cduC-2nzuG:
20.76
6cduD-2nzuG:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ocf FIBRONECTIN

(Homo sapiens) 		PF00041
(fn3) 		4 ILE D  70
VAL D  10
ALA D  13
THR D  14
 None
 0.98A 6cduC-2ocfD:
undetectable
6cduD-2ocfD:
2.4		 6cduC-2ocfD:
18.52
6cduD-2ocfD:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okc TYPE I RESTRICTION
ENZYME STYSJI M
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF02384
(N6_Mtase)
PF12161
(HsdM_N) 		4 ILE A 256
VAL A 174
ALA A 188
THR A 187
 None
 0.71A 6cduC-2okcA:
undetectable
6cduD-2okcA:
undetectable		 6cduC-2okcA:
19.91
6cduD-2okcA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oys HYPOTHETICAL PROTEIN
SP1951

(Streptococcus
pneumoniae) 		PF03358
(FMN_red) 		4 ILE A 154
VAL A 152
ALA A 169
THR A 170
 None
 0.92A 6cduC-2oysA:
undetectable
6cduD-2oysA:
undetectable		 6cduC-2oysA:
22.62
6cduD-2oysA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r05 PROGRAMMED CELL
DEATH 6-INTERACTING
PROTEIN

(Homo sapiens) 		PF03097
(BRO1)
PF13949
(ALIX_LYPXL_bnd) 		4 ILE A 534
PRO A 414
ALA A 659
THR A 658
 None
 0.95A 6cduC-2r05A:
2.9
6cduD-2r05A:
2.6		 6cduC-2r05A:
19.25
6cduD-2r05A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbe BIPOLAR KINESIN
KRP-130

(Drosophila
melanogaster) 		PF00225
(Kinesin) 		4 GLN C   9
VAL C  10
ALA C 319
THR C 320
 None
 0.95A 6cduC-2wbeC:
undetectable
6cduD-2wbeC:
undetectable		 6cduC-2wbeC:
21.66
6cduD-2wbeC:
21.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zf5 GLYCEROL KINASE

(Thermococcus
kodakarensis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		4 ILE O 360
VAL O 335
ALA O 372
THR O 373
 None
 0.92A 6cduC-2zf5O:
undetectable
6cduD-2zf5O:
undetectable		 6cduC-2zf5O:
22.09
6cduD-2zf5O:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak4 NADH-DEPENDENT
QUINUCLIDINONE
REDUCTASE

(Agrobacterium
tumefaciens) 		PF13561
(adh_short_C2) 		4 ILE A  78
GLN A  75
ALA A  39
THR A  15
 None
 0.90A 6cduC-3ak4A:
undetectable
6cduD-3ak4A:
undetectable		 6cduC-3ak4A:
21.26
6cduD-3ak4A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bjb PROBABLE
TRANSCRIPTIONAL
REGULATOR, TETR
FAMILY PROTEIN

(Rhodococcus
jostii) 		PF00440
(TetR_N) 		4 ILE A 119
GLN A 120
ALA A  33
THR A  34
 None
 0.94A 6cduC-3bjbA:
3.5
6cduD-3bjbA:
3.4		 6cduC-3bjbA:
20.87
6cduD-3bjbA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ch8 FUSION PROTEIN
PDZ-FIBRONECTIN

(Homo sapiens) 		PF00041
(fn3)
PF00595
(PDZ) 		4 ILE A 173
VAL A 112
ALA A 115
THR A 116
 None
None
None
MG  A 401 ( 4.6A)
 0.97A 6cduC-3ch8A:
undetectable
6cduD-3ch8A:
undetectable		 6cduC-3ch8A:
22.36
6cduD-3ch8A:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csg MALTOSE-BINDING
PROTEIN MONOBODY YS1
FUSION

(Escherichia
coli) 		PF00041
(fn3)
PF13416
(SBP_bac_8) 		4 ILE A 441
VAL A 380
ALA A 383
THR A 384
 None
 0.96A 6cduC-3csgA:
undetectable
6cduD-3csgA:
undetectable		 6cduC-3csgA:
21.29
6cduD-3csgA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ec7 PUTATIVE
DEHYDROGENASE

(Salmonella
enterica) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		4 ILE A  62
VAL A  82
ALA A  74
THR A  73
 None
None
NAD  A 400 (-3.8A)
None
 0.87A 6cduC-3ec7A:
undetectable
6cduD-3ec7A:
undetectable		 6cduC-3ec7A:
20.53
6cduD-3ec7A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Clostridium
beijerinckii;
Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ILE A 240
VAL A 183
ALA A 212
THR A 213
 None
 0.95A 6cduC-3fplA:
undetectable
6cduD-3fplA:
undetectable		 6cduC-3fplA:
21.99
6cduD-3fplA:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fsn RETINAL PIGMENT
EPITHELIUM-SPECIFIC
65 KDA PROTEIN

(Bos taurus) 		PF03055
(RPE65) 		4 ILE A 225
VAL A 174
ALA A 177
THR A 178
 None
 0.77A 6cduC-3fsnA:
undetectable
6cduD-3fsnA:
undetectable		 6cduC-3fsnA:
19.67
6cduD-3fsnA:
19.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g6s PUTATIVE
ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE
FAMILY PROTEIN

(Bacteroides
vulgatus) 		PF03372
(Exo_endo_phos) 		4 ILE A 239
VAL A 202
ALA A 199
THR A 198
 None
 0.99A 6cduC-3g6sA:
undetectable
6cduD-3g6sA:
undetectable		 6cduC-3g6sA:
20.47
6cduD-3g6sA:
20.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3go7 RIBOKINASE RBSK

(Mycobacterium
tuberculosis) 		PF00294
(PfkB) 		4 GLN A  56
VAL A 243
ALA A 276
THR A 277
 None
 0.90A 6cduC-3go7A:
undetectable
6cduD-3go7A:
undetectable		 6cduC-3go7A:
21.45
6cduD-3go7A:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE LARGE
MOLYBDOPTERIN
SUBUNIT

(Eubacterium
barkeri) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		4 GLN A 299
VAL A 333
ALA A 393
THR A 394
 None
 0.99A 6cduC-3hrdA:
undetectable
6cduD-3hrdA:
undetectable		 6cduC-3hrdA:
21.19
6cduD-3hrdA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd5 28S RIBOSOMAL
PROTEIN S11,
MITOCHONDRIAL

(Bos taurus) 		PF00411
(Ribosomal_S11) 		4 ILE K 100
VAL K 102
ALA K 142
THR K 143
 None
 0.82A 6cduC-3jd5K:
undetectable
6cduD-3jd5K:
undetectable		 6cduC-3jd5K:
20.62
6cduD-3jd5K:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jd5 28S RIBOSOMAL
PROTEIN S17,
MITOCHONDRIAL

(Bos taurus) 		PF00366
(Ribosomal_S17) 		4 ILE Q  13
VAL Q  28
ALA Q  26
THR Q  25
 None
None
None
C  A 120 ( 3.3A)
 0.83A 6cduC-3jd5Q:
undetectable
6cduD-3jd5Q:
undetectable		 6cduC-3jd5Q:
17.65
6cduD-3jd5Q:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kw8 PUTATIVE COPPER
OXIDASE

(Streptomyces
coelicolor) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLN A 272
VAL A 219
ALA A 213
THR A 214
 None
 0.93A 6cduC-3kw8A:
undetectable
6cduD-3kw8A:
undetectable		 6cduC-3kw8A:
21.05
6cduD-3kw8A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p1w RABGDI PROTEIN

(Plasmodium
falciparum) 		PF00996
(GDI) 		4 ILE A 333
GLN A 331
ALA A 368
THR A 369
 None
 0.75A 6cduC-3p1wA:
undetectable
6cduD-3p1wA:
undetectable		 6cduC-3p1wA:
21.44
6cduD-3p1wA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3puk SYNTAXIN-BINDING
PROTEIN 3

(Mus musculus) 		PF00995
(Sec1) 		4 ILE A 567
GLN A 143
VAL A 147
ALA A 548
 None
 0.78A 6cduC-3pukA:
undetectable
6cduD-3pukA:
undetectable		 6cduC-3pukA:
19.77
6cduD-3pukA:
19.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qht MONOBODY YSMB-1

(synthetic
construct) 		PF00041
(fn3) 		4 ILE C  70
VAL C  10
ALA C  13
THR C  14
 None
 0.95A 6cduC-3qhtC:
undetectable
6cduD-3qhtC:
undetectable		 6cduC-3qhtC:
16.98
6cduD-3qhtC:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qwr ADNECTIN

(Homo sapiens) 		PF00041
(fn3) 		4 ILE D  70
VAL D  10
ALA D  13
THR D  14
 None
 0.98A 6cduC-3qwrD:
undetectable
6cduD-3qwrD:
undetectable		 6cduC-3qwrD:
15.38
6cduD-3qwrD:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tbb SMALL LACCASE,
OXIDOREDUCTASE

(Streptomyces
viridosporus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLN A 267
VAL A 214
ALA A 208
THR A 209
 None
 0.96A 6cduC-3tbbA:
undetectable
6cduD-3tbbA:
undetectable		 6cduC-3tbbA:
21.64
6cduD-3tbbA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vth HYDROGENASE
MATURATION FACTOR

(Caldanaerobacter
subterraneus) 		PF00708
(Acylphosphatase)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		4 VAL A 594
PRO A 649
ALA A 592
THR A 591
 None
 0.98A 6cduC-3vthA:
undetectable
6cduD-3vthA:
undetectable		 6cduC-3vthA:
17.30
6cduD-3vthA:
17.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0l GLUCOKINASE
REGULATORY PROTEIN

(Xenopus laevis) 		no annotation 4 ILE B  30
VAL B 249
ALA B 265
THR B 266
 None
 0.91A 6cduC-3w0lB:
3.7
6cduD-3w0lB:
3.7		 6cduC-3w0lB:
20.34
6cduD-3w0lB:
20.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3won DIPEPTIDYL
AMINOPEPTIDASE BII

(Pseudoxanthomonas
mexicana) 		PF10459
(Peptidase_S46) 		4 ILE A 345
GLN A 350
ALA A 289
THR A 288
 None
 0.91A 6cduC-3wonA:
3.6
6cduD-3wonA:
3.4		 6cduC-3wonA:
17.68
6cduD-3wonA:
17.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cj0 ENDOGLUCANASE D
E12 AFFITIN

(Ruminiclostridium
thermocellum;
synthetic
construct) 		PF00759
(Glyco_hydro_9)
PF02927
(CelD_N)
PF02294
(7kD_DNA_binding) 		4 GLN B  35
VAL B  34
PRO A 539
ALA B  54
 None
 0.94A 6cduC-4cj0B:
undetectable
6cduD-4cj0B:
undetectable		 6cduC-4cj0B:
13.27
6cduD-4cj0B:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cuk D-LACTATE
DEHYDROGENASE

(Salmonella
enterica) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ILE A  72
VAL A  69
ALA A  42
THR A  41
 None
 0.91A 6cduC-4cukA:
undetectable
6cduD-4cukA:
undetectable		 6cduC-4cukA:
21.35
6cduD-4cukA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gyb COPPER OXIDASE

(Streptomyces
lividans) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLN A 272
VAL A 219
ALA A 213
THR A 214
 None
 0.91A 6cduC-4gybA:
undetectable
6cduD-4gybA:
undetectable		 6cduC-4gybA:
19.11
6cduD-4gybA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4izo PHOSPHORIBOSYLAMINOI
MIDAZOLE
CARBOXYLASE, ATPASE
SUBUNIT

(Burkholderia
thailandensis) 		PF02222
(ATP-grasp) 		4 GLN A 346
VAL A 347
ALA A 353
THR A 352
 None
 0.83A 6cduC-4izoA:
undetectable
6cduD-4izoA:
undetectable		 6cduC-4izoA:
21.35
6cduD-4izoA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j8l UNCHARACTERIZED
PROTEIN YHFS

(Escherichia
coli) 		PF00155
(Aminotran_1_2) 		4 ILE A 116
GLN A 133
VAL A 130
ALA A 163
 None
 0.91A 6cduC-4j8lA:
undetectable
6cduD-4j8lA:
undetectable		 6cduC-4j8lA:
24.10
6cduD-4j8lA:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4je4 MONOBODY NSA1

(Homo sapiens) 		PF00041
(fn3) 		4 ILE B  71
VAL B  10
ALA B  13
THR B  14
 None
 0.93A 6cduC-4je4B:
2.0
6cduD-4je4B:
undetectable		 6cduC-4je4B:
16.06
6cduD-4je4B:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kd5 ABC-TYPE TRANSPORT
SYSTEM,
MOLYBDENUM-SPECIFIC
EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Clostridioides
difficile) 		no annotation 4 ILE C 215
GLN C 195
VAL C 194
ALA C 151
 None
 0.78A 6cduC-4kd5C:
undetectable
6cduD-4kd5C:
undetectable		 6cduC-4kd5C:
21.61
6cduD-4kd5C:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lix ENT-COPALYL
DIPHOSPHATE
SYNTHASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF01397
(Terpene_synth)
PF03936
(Terpene_synth_C) 		4 ILE A 480
VAL A 489
ALA A 571
THR A 572
 None
 0.92A 6cduC-4lixA:
5.0
6cduD-4lixA:
5.0		 6cduC-4lixA:
17.70
6cduD-4lixA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lxo FIBRONECTIN

(Homo sapiens) 		PF00041
(fn3) 		4 ILE A1485
VAL A1425
ALA A1428
THR A1429
 None
 0.93A 6cduC-4lxoA:
undetectable
6cduD-4lxoA:
1.8		 6cduC-4lxoA:
20.91
6cduD-4lxoA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1r CELLULASE 5

(soil metagenome) 		PF00150
(Cellulase) 		4 VAL A 164
PRO A 215
ALA A 146
THR A 147
 None
 0.78A 6cduC-4m1rA:
undetectable
6cduD-4m1rA:
undetectable		 6cduC-4m1rA:
21.84
6cduD-4m1rA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rfq HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG

(Homo sapiens) 		PF13489
(Methyltransf_23) 		4 ILE A 290
VAL A 191
ALA A 205
THR A 204
 None
 0.90A 6cduC-4rfqA:
undetectable
6cduD-4rfqA:
undetectable		 6cduC-4rfqA:
20.24
6cduD-4rfqA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rma EZRIN

(Homo sapiens) 		PF00373
(FERM_M)
PF09379
(FERM_N)
PF09380
(FERM_C) 		4 GLN A 160
VAL A 157
ALA A 122
THR A 121
 None
 0.89A 6cduC-4rmaA:
undetectable
6cduD-4rmaA:
undetectable		 6cduC-4rmaA:
17.54
6cduD-4rmaA:
17.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4tnw AVERMECTIN-SENSITIVE
GLUTAMATE-GATED
CHLORIDE CHANNEL
GLUCL ALPHA

(Caenorhabditis
elegans) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		4 ILE A 229
VAL A 233
TRP A 236
PRO A 324
 None
 0.46A 6cduC-4tnwA:
4.0
6cduD-4tnwA:
18.6		 6cduC-4tnwA:
31.77
6cduD-4tnwA:
31.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u3t PENICILLIN-BINDING
PROTEIN 2

(Neisseria
gonorrhoeae) 		PF00905
(Transpeptidase) 		4 ILE A 388
PRO A 308
ALA A 437
THR A 436
 None
 0.94A 6cduC-4u3tA:
undetectable
6cduD-4u3tA:
undetectable		 6cduC-4u3tA:
21.30
6cduD-4u3tA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uaq PROTEIN TRANSLOCASE
SUBUNIT SECA 2

(Mycobacterium
tuberculosis) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 ILE A 215
VAL A 106
ALA A 387
THR A 386
 None
 0.97A 6cduC-4uaqA:
undetectable
6cduD-4uaqA:
3.5		 6cduC-4uaqA:
16.58
6cduD-4uaqA:
16.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uc0 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Agrobacterium
vitis) 		PF01048
(PNP_UDP_1) 		4 ILE A 169
VAL A 121
ALA A 222
THR A 106
 None
 0.95A 6cduC-4uc0A:
undetectable
6cduD-4uc0A:
undetectable		 6cduC-4uc0A:
21.47
6cduD-4uc0A:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uek GALACTITOL-1-PHOSPHA
TE 5-DEHYDROGENASE

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 ILE A 233
GLN A 231
VAL A 164
ALA A 180
 None
 0.98A 6cduC-4uekA:
undetectable
6cduD-4uekA:
undetectable		 6cduC-4uekA:
21.31
6cduD-4uekA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w1t COPPER OXIDASE

(Streptomyces
sviceus) 		PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		4 GLN A 269
VAL A 216
ALA A 210
THR A 211
 None
 0.95A 6cduC-4w1tA:
undetectable
6cduD-4w1tA:
undetectable		 6cduC-4w1tA:
21.49
6cduD-4w1tA:
21.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w8x CRISPR SYSTEM CMR
SUBUNIT CMR1-1

(Pyrococcus
furiosus) 		PF03787
(RAMPs) 		4 ILE A  58
GLN A  61
VAL A  62
ALA A 136
 None
 0.80A 6cduC-4w8xA:
undetectable
6cduD-4w8xA:
undetectable		 6cduC-4w8xA:
20.95
6cduD-4w8xA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xg0 UNCHARACTERIZED
PROTEIN

(Bordetella
bronchiseptica) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		4 GLN A 199
VAL A 198
ALA A 119
THR A 126
 None
 0.84A 6cduC-4xg0A:
undetectable
6cduD-4xg0A:
undetectable		 6cduC-4xg0A:
19.09
6cduD-4xg0A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgs PUTATIVE D-LACTATE
DEHYDROGENASE

(Chlamydomonas
reinhardtii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		4 ILE A 264
VAL A 266
ALA A 337
THR A 336
 None
None
NAD  A1000 ( 3.6A)
None
 0.81A 6cduC-4zgsA:
undetectable
6cduD-4zgsA:
undetectable		 6cduC-4zgsA:
21.58
6cduD-4zgsA:
21.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bwa ORNITHINE
DECARBOXYLASE

(Homo sapiens) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		4 ILE A 108
GLN A  99
VAL A 103
ALA A  81
 None
 0.84A 6cduC-5bwaA:
undetectable
6cduD-5bwaA:
undetectable		 6cduC-5bwaA:
18.67
6cduD-5bwaA:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c54 DIHYDRODIPICOLINATE
SYNTHASE/N-ACETYLNEU
RAMINATE LYASE

(Corynebacterium
glutamicum) 		PF00701
(DHDPS) 		4 VAL A 219
PRO A  12
ALA A 274
THR A 273
 None
 0.99A 6cduC-5c54A:
undetectable
6cduD-5c54A:
undetectable		 6cduC-5c54A:
21.41
6cduD-5c54A:
21.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5czz CRISPR-ASSOCIATED
ENDONUCLEASE CAS9

(Staphylococcus
aureus) 		PF13395
(HNH_4)
PF16592
(Cas9_REC) 		4 ILE A  13
VAL A 450
ALA A 652
THR A 653
 None
 0.85A 6cduC-5czzA:
3.4
6cduD-5czzA:
3.4		 6cduC-5czzA:
14.47
6cduD-5czzA:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dc0 FIBRONECTIN

(Homo sapiens) 		PF00041
(fn3) 		4 ILE A  70
VAL A  10
ALA A  13
THR A  14
 None
 0.93A 6cduC-5dc0A:
undetectable
6cduD-5dc0A:
undetectable		 6cduC-5dc0A:
15.86
6cduD-5dc0A:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dc4 AS25 MONOBODY

(Homo sapiens) 		PF00041
(fn3) 		4 ILE B  72
VAL B  12
ALA B  15
THR B  16
 None
 0.96A 6cduC-5dc4B:
1.7
6cduD-5dc4B:
undetectable		 6cduC-5dc4B:
15.74
6cduD-5dc4B:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		4 ILE A  40
GLN A  38
VAL A  59
ALA A  78
 None
 0.74A 6cduC-5dmhA:
undetectable
6cduD-5dmhA:
undetectable		 6cduC-5dmhA:
21.74
6cduD-5dmhA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ecj MONOBODY MB(S4)

(Homo sapiens) 		no annotation 4 ILE F  70
VAL F  10
ALA F  13
THR F  14
 None
 0.98A 6cduC-5ecjF:
undetectable
6cduD-5ecjF:
undetectable		 6cduC-5ecjF:
16.67
6cduD-5ecjF:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fpn HEAT SHOCK-RELATED
70 KDA PROTEIN 2

(Homo sapiens) 		PF00012
(HSP70) 		4 ILE A 333
GLN A 334
ALA A 180
THR A 177
 None
 0.90A 6cduC-5fpnA:
undetectable
6cduD-5fpnA:
undetectable		 6cduC-5fpnA:
18.10
6cduD-5fpnA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ha4 DIAMINOPIMELATE
EPIMERASE

(Acinetobacter
baumannii) 		PF01678
(DAP_epimerase) 		4 ILE A 178
GLN A 181
VAL A 182
ALA A 163
 None
 0.79A 6cduC-5ha4A:
undetectable
6cduD-5ha4A:
undetectable		 6cduC-5ha4A:
19.41
6cduD-5ha4A:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j7c FNFN10-ANTI-LYSOZYME
(DE0.4.1)

(Homo sapiens) 		PF00041
(fn3) 		4 ILE C  71
VAL C  11
ALA C  14
THR C  15
 None
 0.97A 6cduC-5j7cC:
undetectable
6cduD-5j7cC:
undetectable		 6cduC-5j7cC:
13.89
6cduD-5j7cC:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kju SHIKIMATE
O-HYDROXYCINNAMOYLTR
ANSFERASE

(Arabidopsis
thaliana) 		PF02458
(Transferase) 		4 ILE A   5
GLN A 136
VAL A  95
PRO A 119
 None
 0.94A 6cduC-5kjuA:
undetectable
6cduD-5kjuA:
undetectable		 6cduC-5kjuA:
21.95
6cduD-5kjuA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksh PENICILLIN-BINDING
PROTEIN 2

(Neisseria
gonorrhoeae) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		4 ILE A 388
PRO A 308
ALA A 437
THR A 436
 None
 0.99A 6cduC-5kshA:
undetectable
6cduD-5kshA:
undetectable		 6cduC-5kshA:
20.36
6cduD-5kshA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkm TWO-DOMAIN LACCASE

(Streptomyces
griseoflavus) 		no annotation 4 GLN A 273
VAL A 220
ALA A 214
THR A 215
 None
 0.90A 6cduC-5mkmA:
undetectable
6cduD-5mkmA:
undetectable		 6cduC-5mkmA:
undetectable
6cduD-5mkmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mtj MONOBODY MB(YES_1)

(Homo sapiens) 		PF00041
(fn3) 		4 ILE B  70
VAL B  10
ALA B  13
THR B  14
 None
None
None
CXS  B 102 (-3.7A)
 0.95A 6cduC-5mtjB:
undetectable
6cduD-5mtjB:
2.0		 6cduC-5mtjB:
16.98
6cduD-5mtjB:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mtm MONOBODY MB(LCK_3)

(Mus musculus) 		PF00041
(fn3) 		4 ILE B  73
VAL B  12
ALA B  15
THR B  16
 None
 0.96A 6cduC-5mtmB:
undetectable
6cduD-5mtmB:
undetectable		 6cduC-5mtmB:
16.67
6cduD-5mtmB:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mtn MONOBODY MB(LCK_1)

(synthetic
construct) 		PF00041
(fn3) 		4 ILE B  73
VAL B  12
ALA B  15
THR B  16
 None
 0.92A 6cduC-5mtnB:
undetectable
6cduD-5mtnB:
undetectable		 6cduC-5mtnB:
15.74
6cduD-5mtnB:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n7e MB(BCR-DH_4)

(synthetic
construct) 		no annotation 4 ILE A  71
VAL A  11
ALA A  14
THR A  15
 None
 0.96A 6cduC-5n7eA:
undetectable
6cduD-5n7eA:
undetectable		 6cduC-5n7eA:
undetectable
6cduD-5n7eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o30 PUTATIVE
OXIDOREDUCTASE

(Ilumatobacter
coccineus) 		PF13561
(adh_short_C2) 		4 ILE A 219
GLN A 222
VAL A 223
TRP A 260
 None
 0.80A 6cduC-5o30A:
undetectable
6cduD-5o30A:
undetectable		 6cduC-5o30A:
21.94
6cduD-5o30A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o60 50S RIBOSOMAL
PROTEIN L25

(Mycolicibacterium
smegmatis) 		PF01386
(Ribosomal_L25p)
PF14693
(Ribosomal_TL5_C) 		4 ILE W 157
VAL W 148
ALA W 118
THR W 119
 None
 0.86A 6cduC-5o60W:
undetectable
6cduD-5o60W:
undetectable		 6cduC-5o60W:
20.91
6cduD-5o60W:
20.91
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5o8f GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-3,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT
ALPHA-5,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-5

(Homo sapiens) 		no annotation 5 ILE A 242
GLN A 245
VAL A 246
TRP A 249
PRO A 403
 None
 0.41A 6cduC-5o8fA:
21.2
6cduD-5o8fA:
20.9		 6cduC-5o8fA:
48.09
6cduD-5o8fA:
48.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9w THEBAINE
6-O-DEMETHYLASE

(Papaver
somniferum) 		no annotation 4 GLN A  89
VAL A 276
PRO A 269
THR A 310
 None
 0.88A 6cduC-5o9wA:
undetectable
6cduD-5o9wA:
undetectable		 6cduC-5o9wA:
undetectable
6cduD-5o9wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oc7 MONOBODY
MB(BCR-PH_4)

(synthetic
construct) 		no annotation 4 ILE C  72
VAL C  12
ALA C  15
THR C  16
 None
 0.94A 6cduC-5oc7C:
undetectable
6cduD-5oc7C:
1.8		 6cduC-5oc7C:
undetectable
6cduD-5oc7C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		4 ILE T1770
VAL T1806
ALA T1786
THR T1787
 None
 0.85A 6cduC-5ojsT:
undetectable
6cduD-5ojsT:
undetectable		 6cduC-5ojsT:
6.75
6cduD-5ojsT:
6.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ol2 ELECTRON TRANSFER
FLAVOPROTEIN LARGE
SUBUNIT

(Clostridioides
difficile) 		no annotation 4 ILE A   8
VAL A   6
ALA A  26
THR A  27
 None
 0.74A 6cduC-5ol2A:
undetectable
6cduD-5ol2A:
undetectable		 6cduC-5ol2A:
22.40
6cduD-5ol2A:
22.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5osb PROTON-GATED ION
CHANNEL,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1

(Mus musculus;
Gloeobacter
violaceus) 		no annotation 5 ILE A 238
GLN A 241
VAL A 242
TRP A 245
PRO A 400
 A8Z  A 502 ( 3.8A)
A8Z  A 502 (-2.8A)
A8Z  A 502 (-2.9A)
A8Z  A 502 ( 2.8A)
A8Z  A 502 (-3.1A)
 0.46A 6cduC-5osbA:
26.9
6cduD-5osbA:
20.2		 6cduC-5osbA:
49.40
6cduD-5osbA:
49.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szn PROTOCADHERIN GAMMA
A9

(Mus musculus) 		PF00028
(Cadherin)
PF08266
(Cadherin_2) 		4 ILE A 321
VAL A 319
ALA A 396
THR A 395
 None
 0.94A 6cduC-5sznA:
3.3
6cduD-5sznA:
3.3		 6cduC-5sznA:
19.47
6cduD-5sznA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vaw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TYPE IV
PILIN PILA

(Acinetobacter
baumannii;
Escherichia
coli) 		no annotation 4 ILE A1074
VAL A1033
ALA A1139
THR A1138
 None
 0.99A 6cduC-5vawA:
undetectable
6cduD-5vawA:
undetectable		 6cduC-5vawA:
undetectable
6cduD-5vawA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vbf NAD-DEPENDENT
SUCCINATE-SEMIALDEHY
DE DEHYDROGENASE

(Burkholderia
vietnamiensis) 		PF00171
(Aldedh) 		4 ILE A 341
VAL A 345
PRO A 388
THR A 357
 None
 0.99A 6cduC-5vbfA:
undetectable
6cduD-5vbfA:
undetectable		 6cduC-5vbfA:
20.75
6cduD-5vbfA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vmk BIFUNCTIONAL PROTEIN
GLMU

(Acinetobacter
baumannii) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3)
PF14602
(Hexapep_2) 		4 ILE A  49
VAL A   5
PRO A  91
ALA A  40
 None
 0.85A 6cduC-5vmkA:
undetectable
6cduD-5vmkA:
undetectable		 6cduC-5vmkA:
21.33
6cduD-5vmkA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vy3 PROTEASOME SUBUNIT
ALPHA

(Thermoplasma
acidophilum) 		no annotation 4 GLN A  68
VAL A  77
ALA A  37
THR A  36
 None
 0.95A 6cduC-5vy3A:
undetectable
6cduD-5vy3A:
undetectable		 6cduC-5vy3A:
22.63
6cduD-5vy3A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apx MONOBODY YSX1

(synthetic
construct) 		no annotation 4 ILE B  70
VAL B   8
ALA B  11
THR B  12
 None
 0.92A 6cduC-6apxB:
undetectable
6cduD-6apxB:
undetectable		 6cduC-6apxB:
16.92
6cduD-6apxB:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b2b MONOBODY

(Homo sapiens) 		no annotation 4 ILE C  71
VAL C  11
ALA C  14
THR C  15
 None
 0.93A 6cduC-6b2bC:
undetectable
6cduD-6b2bC:
undetectable		 6cduC-6b2bC:
17.45
6cduD-6b2bC:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bqo MONOBODY S8

(Homo sapiens) 		no annotation 4 ILE C  71
VAL C  11
ALA C  14
THR C  15
 None
 0.95A 6cduC-6bqoC:
undetectable
6cduD-6bqoC:
undetectable		 6cduC-6bqoC:
undetectable
6cduD-6bqoC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byn WDR5-BINDING
MONOBODY, MB(S4)

(Homo sapiens) 		no annotation 4 ILE M  70
VAL M  10
ALA M  13
THR M  14
 None
 0.97A 6cduC-6bynM:
undetectable
6cduD-6bynM:
undetectable		 6cduC-6bynM:
undetectable
6cduD-6bynM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ez8 HUNTINGTIN

(Homo sapiens) 		no annotation 4 GLN A2177
VAL A2176
ALA A2251
THR A2252
 None
 0.80A 6cduC-6ez8A:
undetectable
6cduD-6ez8A:
undetectable		 6cduC-6ez8A:
undetectable
6cduD-6ez8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f4c ALPHA-GALACTOSIDASE

(Nicotiana
benthamiana) 		no annotation 4 GLN B 322
VAL B 320
PRO B  60
ALA B 351
 None
 0.95A 6cduC-6f4cB:
undetectable
6cduD-6f4cB:
undetectable		 6cduC-6f4cB:
undetectable
6cduD-6f4cB:
undetectable