SIMILAR PATTERNS OF AMINO ACIDS FOR 6CDU_A_EY4A501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bou 4,5-DIOXYGENASE BETA
CHAIN

(Sphingomonas
paucimobilis) 		PF02900
(LigB) 		4 VAL B 187
TRP B 188
PRO B  51
THR B 190
 None
 1.34A 6cduA-1bouB:
0.0
6cduB-1bouB:
undetectable		 6cduA-1bouB:
21.15
6cduB-1bouB:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j6q CYTOCHROME C
MATURATION PROTEIN E

(Shewanella
putrefaciens) 		PF03100
(CcmE) 		4 GLN A  58
VAL A 115
PRO A  54
THR A  95
 None
 1.10A 6cduA-1j6qA:
undetectable
6cduB-1j6qA:
undetectable		 6cduA-1j6qA:
17.33
6cduB-1j6qA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jfx 1,4-BETA-N-ACETYLMUR
AMIDASE M1

(Streptomyces
coelicolor) 		PF01183
(Glyco_hydro_25) 		4 GLN A 183
VAL A 162
TRP A 182
THR A 171
 None
 1.45A 6cduA-1jfxA:
undetectable
6cduB-1jfxA:
undetectable		 6cduA-1jfxA:
23.55
6cduB-1jfxA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sq5 PANTOTHENATE KINASE

(Escherichia
coli) 		PF00485
(PRK) 		4 GLN A1205
VAL A1203
PRO A1148
THR A1125
 None
 1.34A 6cduA-1sq5A:
undetectable
6cduB-1sq5A:
0.0		 6cduA-1sq5A:
21.85
6cduB-1sq5A:
21.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tt7 YHFP

(Bacillus
subtilis) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 VAL A 284
TRP A 285
PRO A 117
THR A 134
 None
 1.41A 6cduA-1tt7A:
0.0
6cduB-1tt7A:
0.0		 6cduA-1tt7A:
23.81
6cduB-1tt7A:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u2z HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC

(Saccharomyces
cerevisiae) 		PF08123
(DOT1) 		4 GLN A 408
VAL A 407
PRO A 377
THR A 431
 None
 1.50A 6cduA-1u2zA:
0.0
6cduB-1u2zA:
0.0		 6cduA-1u2zA:
20.83
6cduB-1u2zA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z48 PROBABLE
NADH-DEPENDENT
FLAVIN
OXIDOREDUCTASE YQJM

(Bacillus
subtilis) 		PF00724
(Oxidored_FMN) 		4 GLN A 102
VAL A 214
PRO A  24
THR A 280
 FMN  A1500 (-2.9A)
None
FMN  A1500 (-4.1A)
None
 1.49A 6cduA-1z48A:
0.0
6cduB-1z48A:
0.0		 6cduA-1z48A:
22.81
6cduB-1z48A:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aey FRUCTAN
1-EXOHYDROLASE IIA

(Cichorium
intybus) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 GLN A 311
VAL A 293
TRP A 292
PRO A  23
 None
 1.39A 6cduA-2aeyA:
0.0
6cduB-2aeyA:
0.0		 6cduA-2aeyA:
21.88
6cduB-2aeyA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g0b FEEM

(uncultured
bacterium) 		no annotation 4 GLN A 183
VAL A 177
TRP A 180
THR A 127
 None
 1.22A 6cduA-2g0bA:
0.0
6cduB-2g0bA:
0.0		 6cduA-2g0bA:
20.61
6cduB-2g0bA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hng HYPOTHETICAL PROTEIN

(Streptococcus
pneumoniae) 		PF06619
(DUF1149) 		4 GLN A  76
VAL A  77
PRO A 102
THR A  53
 None
 1.34A 6cduA-2hngA:
undetectable
6cduB-2hngA:
undetectable		 6cduA-2hngA:
19.06
6cduB-2hngA:
19.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iv2 FORMATE
DEHYDROGENASE H

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		4 GLN X 121
VAL X 119
PRO X 352
THR X 498
 None
 1.12A 6cduA-2iv2X:
undetectable
6cduB-2iv2X:
undetectable		 6cduA-2iv2X:
17.97
6cduB-2iv2X:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jer AGMATINE DEIMINASE

(Enterococcus
faecalis) 		PF04371
(PAD_porph) 		4 GLN A 360
VAL A  27
TRP A  28
PRO A  99
 None
 1.35A 6cduA-2jerA:
undetectable
6cduB-2jerA:
undetectable		 6cduA-2jerA:
23.47
6cduB-2jerA:
23.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l8b PROTEIN TRAI

(Escherichia
coli) 		no annotation 4 GLN A 531
VAL A 532
PRO A 431
THR A 535
 None
 1.37A 6cduA-2l8bA:
undetectable
6cduB-2l8bA:
undetectable		 6cduA-2l8bA:
19.14
6cduB-2l8bA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rez MULTIFUNCTIONAL
CYCLASE-DEHYDRATASE-
3-O-METHYL
TRANSFERASE TCMN

(Streptomyces
glaucescens) 		PF03364
(Polyketide_cyc) 		4 GLN A 110
VAL A 109
TRP A  95
THR A  77
 None
 1.37A 6cduA-2rezA:
undetectable
6cduB-2rezA:
undetectable		 6cduA-2rezA:
19.75
6cduB-2rezA:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rn7 IS629 ORFA

(Shigella
flexneri) 		PF01527
(HTH_Tnp_1) 		4 GLN A  53
VAL A  49
TRP A  50
THR A  43
 None
 1.36A 6cduA-2rn7A:
undetectable
6cduB-2rn7A:
undetectable		 6cduA-2rn7A:
15.08
6cduB-2rn7A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rsd E3 SUMO-PROTEIN
LIGASE SIZ1

(Oryza sativa) 		PF00628
(PHD) 		4 GLN A 137
VAL A 138
TRP A 139
THR A 122
 None
 1.24A 6cduA-2rsdA:
undetectable
6cduB-2rsdA:
undetectable		 6cduA-2rsdA:
11.53
6cduB-2rsdA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ux7 PSEUDOAZURIN

(Achromobacter
cycloclastes) 		PF00127
(Copper-bind) 		4 GLN A  89
VAL A  88
PRO A  94
THR A  44
 None
 1.06A 6cduA-2ux7A:
undetectable
6cduB-2ux7A:
undetectable		 6cduA-2ux7A:
16.92
6cduB-2ux7A:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xmo LMO2642 PROTEIN

(Listeria
monocytogenes) 		PF00149
(Metallophos) 		4 GLN A 127
VAL A 128
PRO A 187
THR A  45
 None
 1.46A 6cduA-2xmoA:
undetectable
6cduB-2xmoA:
undetectable		 6cduA-2xmoA:
21.17
6cduB-2xmoA:
21.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xn8 PUTATIVE CYTOCHROME
P450 125

(Mycobacterium
tuberculosis) 		PF00067
(p450) 		4 GLN A 317
VAL A 337
PRO A  98
THR A  74
 None
 1.44A 6cduA-2xn8A:
1.5
6cduB-2xn8A:
1.3		 6cduA-2xn8A:
21.00
6cduB-2xn8A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zxq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Bifidobacterium
longum) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		4 VAL A 925
TRP A 924
PRO A 928
THR A 953
 None
 1.38A 6cduA-2zxqA:
undetectable
6cduB-2zxqA:
undetectable		 6cduA-2zxqA:
12.64
6cduB-2zxqA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d34 SPONDIN-2

(Homo sapiens) 		PF06468
(Spond_N) 		4 GLN A  42
VAL A 103
TRP A  43
THR A  22
 None
 1.28A 6cduA-3d34A:
undetectable
6cduB-3d34A:
undetectable		 6cduA-3d34A:
20.95
6cduB-3d34A:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm0 MALTOSE-BINDING
PERIPLASMIC PROTEIN
FUSED WITH RACK1

(Escherichia
coli;
Arabidopsis
thaliana) 		PF00400
(WD40)
PF01547
(SBP_bac_1) 		4 GLN A1119
VAL A1121
TRP A1132
THR A1128
 None
 1.17A 6cduA-3dm0A:
undetectable
6cduB-3dm0A:
undetectable		 6cduA-3dm0A:
18.16
6cduB-3dm0A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e49 UNCHARACTERIZED
PROTEIN DUF849 WITH
A TIM BARREL FOLD

(Paraburkholderia
xenovorans) 		PF05853
(BKACE) 		4 GLN A 197
VAL A 196
TRP A 230
THR A 219
 None
 1.08A 6cduA-3e49A:
undetectable
6cduB-3e49A:
undetectable		 6cduA-3e49A:
23.36
6cduB-3e49A:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fw6 CELLULASE

(uncultured
bacterium) 		PF12891
(Glyco_hydro_44) 		4 GLN A 512
VAL A 541
PRO A 537
THR A 407
 None
 1.37A 6cduA-3fw6A:
undetectable
6cduB-3fw6A:
undetectable		 6cduA-3fw6A:
22.84
6cduB-3fw6A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i2m ORF59

(Human
gammaherpesvirus
8) 		PF04929
(Herpes_DNAp_acc) 		4 GLN X  36
VAL X  37
PRO X 152
THR X  43
 None
 1.12A 6cduA-3i2mX:
undetectable
6cduB-3i2mX:
undetectable		 6cduA-3i2mX:
25.47
6cduB-3i2mX:
25.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxu TRIPEPTIDYL-PEPTIDAS
E 2

(Drosophila
melanogaster) 		PF00082
(Peptidase_S8)
PF12580
(TPPII)
PF12583
(TPPII_N) 		4 GLN X 433
VAL X 435
PRO X 647
THR X 381
 None
 1.37A 6cduA-3lxuX:
3.4
6cduB-3lxuX:
3.1		 6cduA-3lxuX:
13.16
6cduB-3lxuX:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o1h PERIPLASMIC PROTEIN
TORT

(Vibrio
parahaemolyticus) 		PF00532
(Peripla_BP_1) 		4 VAL B 138
TRP B 140
PRO B 178
THR B 271
 None
 1.37A 6cduA-3o1hB:
undetectable
6cduB-3o1hB:
undetectable		 6cduA-3o1hB:
20.40
6cduB-3o1hB:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sbq NITROUS-OXIDE
REDUCTASE

(Pseudomonas
stutzeri) 		no annotation 4 VAL A 319
TRP A 274
PRO A 325
THR A 316
 None
 1.42A 6cduA-3sbqA:
undetectable
6cduB-3sbqA:
undetectable		 6cduA-3sbqA:
17.94
6cduB-3sbqA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tee FLAGELLA BASAL BODY
P-RING FORMATION
PROTEIN FLGA

(Salmonella
enterica) 		PF13144
(ChapFlgA) 		4 GLN A 131
VAL A 130
PRO A 105
THR A  95
 None
 1.37A 6cduA-3teeA:
undetectable
6cduB-3teeA:
undetectable		 6cduA-3teeA:
20.72
6cduB-3teeA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wev L-LYSINE 6-OXIDASE

(Marinomonas
mediterranea) 		no annotation 4 GLN A  61
VAL A 195
PRO A   7
THR A  86
 None
 1.32A 6cduA-3wevA:
undetectable
6cduB-3wevA:
undetectable		 6cduA-3wevA:
19.50
6cduB-3wevA:
19.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4azv WBDD

(Escherichia
coli) 		PF00069
(Pkinase)
PF13847
(Methyltransf_31) 		4 GLN A 431
VAL A 429
TRP A 430
THR A 384
 None
 1.26A 6cduA-4azvA:
undetectable
6cduB-4azvA:
undetectable		 6cduA-4azvA:
20.88
6cduB-4azvA:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bb9 GLUCOKINASE
REGULATORY PROTEIN

(Homo sapiens) 		no annotation 4 GLN A 420
VAL A 419
PRO A 448
THR A 411
 None
 1.46A 6cduA-4bb9A:
undetectable
6cduB-4bb9A:
undetectable		 6cduA-4bb9A:
18.75
6cduB-4bb9A:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fmv GLUCURONOARABINOXYLA
N
ENDO-1,4-BETA-XYLANA
SE

([Clostridium]
papyrosolvens) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		4 GLN A 336
VAL A 334
PRO A 307
THR A 331
 None
 1.39A 6cduA-4fmvA:
undetectable
6cduB-4fmvA:
undetectable		 6cduA-4fmvA:
20.35
6cduB-4fmvA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gbf PHIKZ131

(Pseudomonas
virus phiKZ) 		no annotation 4 VAL A 492
TRP A 494
PRO A 503
THR A 544
 None
 1.49A 6cduA-4gbfA:
undetectable
6cduB-4gbfA:
undetectable		 6cduA-4gbfA:
21.52
6cduB-4gbfA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4guz PROBABLE ARYLAMINE
N-ACETYL TRANSFERASE

(Mycobacteroides
abscessus) 		PF00797
(Acetyltransf_2) 		4 GLN A 121
VAL A 115
TRP A 122
THR A  25
 None
 1.40A 6cduA-4guzA:
undetectable
6cduB-4guzA:
undetectable		 6cduA-4guzA:
22.44
6cduB-4guzA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzp BIFUNCTIONAL
METHYLMALONYL-COA:AC
P
ACYLTRANSFERASE/DECA
RBOXYLASE

(Streptomyces
atroolivaceus) 		no annotation 4 GLN A  96
VAL A 101
PRO A 175
THR A  41
 None
 1.37A 6cduA-4hzpA:
undetectable
6cduB-4hzpA:
undetectable		 6cduA-4hzpA:
21.81
6cduB-4hzpA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pmh PECTINESTERASE

(Sitophilus
oryzae) 		PF01095
(Pectinesterase) 		4 GLN A 189
VAL A 159
PRO A  33
THR A  85
 None
 1.36A 6cduA-4pmhA:
undetectable
6cduB-4pmhA:
undetectable		 6cduA-4pmhA:
22.10
6cduB-4pmhA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pw8 TRYPTOPHAN
2,3-DIOXYGENASE

(Homo sapiens) 		PF03301
(Trp_dioxygenase) 		4 GLN A 128
VAL A 126
TRP A 324
THR A 322
 None
 1.30A 6cduA-4pw8A:
2.7
6cduB-4pw8A:
1.5		 6cduA-4pw8A:
24.25
6cduB-4pw8A:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi3 CELLOBIOSE
DEHYDROGENASE

(Crassicarpon
hotsonii) 		PF16010
(CDH-cyt) 		4 GLN A 186
VAL A   4
TRP A  20
THR A   7
 MG  A 407 ( 2.9A)
None
None
None
 1.24A 6cduA-4qi3A:
undetectable
6cduB-4qi3A:
undetectable		 6cduA-4qi3A:
20.00
6cduB-4qi3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s17 GLUTAMINE SYNTHETASE

(Bifidobacterium
adolescentis) 		PF00120
(Gln-synt_C)
PF03951
(Gln-synt_N) 		4 GLN A 111
VAL A 112
PRO A 104
THR A 439
 None
 1.05A 6cduA-4s17A:
undetectable
6cduB-4s17A:
undetectable		 6cduA-4s17A:
21.95
6cduB-4s17A:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Nakamurella
multipartita) 		PF00561
(Abhydrolase_1) 		4 GLN A 189
VAL A 187
PRO A 282
THR A 171
 None
 1.46A 6cduA-4y7dA:
undetectable
6cduB-4y7dA:
undetectable		 6cduA-4y7dA:
23.03
6cduB-4y7dA:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5awm STRESS-ACTIVATED
PROTEIN KINASE JNK

(Drosophila
melanogaster) 		PF00069
(Pkinase) 		4 GLN A 350
VAL A 348
TRP A 351
THR A  63
 None
 1.24A 6cduA-5awmA:
undetectable
6cduB-5awmA:
undetectable		 6cduA-5awmA:
21.31
6cduB-5awmA:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c65 SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 3

(Homo sapiens) 		PF00083
(Sugar_tr) 		4 GLN A 277
VAL A 275
PRO A 385
THR A 441
 None
 1.47A 6cduA-5c65A:
2.2
6cduB-5c65A:
1.8		 6cduA-5c65A:
21.24
6cduB-5c65A:
21.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cfa BONE
SIALOPROTEIN-BINDING
PROTEIN

(Staphylococcus
aureus) 		PF10425
(SdrG_C_C) 		4 GLN A 160
VAL A 179
PRO A 151
THR A 296
 None
 1.48A 6cduA-5cfaA:
3.5
6cduB-5cfaA:
3.4		 6cduA-5cfaA:
20.75
6cduB-5cfaA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ckm MANNAN-BINDING
LECTIN SERINE
PEPTIDASE 2

(Rattus
norvegicus) 		PF00431
(CUB)
PF07645
(EGF_CA) 		4 VAL A 214
TRP A 270
PRO A 245
THR A 260
 None
 1.29A 6cduA-5ckmA:
undetectable
6cduB-5ckmA:
undetectable		 6cduA-5ckmA:
21.20
6cduB-5ckmA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum) 		PF02055
(Glyco_hydro_30) 		4 GLN A 336
VAL A 334
PRO A 307
THR A 331
 None
 1.47A 6cduA-5cxpA:
undetectable
6cduB-5cxpA:
undetectable		 6cduA-5cxpA:
22.89
6cduB-5cxpA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d4k POLYMERIC
IMMUNOGLOBULIN
RECEPTOR

(Homo sapiens) 		PF07686
(V-set) 		4 GLN A 325
VAL A 227
TRP A 324
THR A 236
 None
 1.28A 6cduA-5d4kA:
undetectable
6cduB-5d4kA:
undetectable		 6cduA-5d4kA:
20.65
6cduB-5d4kA:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ecf CELL WALL ANTIGEN

(Talaromyces
marneffei) 		PF12296
(HsbA) 		4 GLN A  61
VAL A   8
PRO A  62
THR A  67
 None
 1.40A 6cduA-5ecfA:
2.9
6cduB-5ecfA:
2.3		 6cduA-5ecfA:
21.20
6cduB-5ecfA:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esy SAL1 PHOSPHATASE

(Arabidopsis
thaliana) 		PF00459
(Inositol_P) 		4 GLN A  22
VAL A  24
PRO A 168
THR A  43
 None
 1.30A 6cduA-5esyA:
1.2
6cduB-5esyA:
undetectable		 6cduA-5esyA:
20.82
6cduB-5esyA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ff5 PAAA

(Pantoea
agglomerans) 		PF00899
(ThiF) 		4 GLN A 339
VAL A 340
PRO A 350
THR A 226
 None
 1.48A 6cduA-5ff5A:
undetectable
6cduB-5ff5A:
undetectable		 6cduA-5ff5A:
22.06
6cduB-5ff5A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l8s AMINO ACYL PEPTIDASE

(Sporosarcina
psychrophila) 		PF00326
(Peptidase_S9) 		4 GLN A  11
VAL A 333
PRO A   7
THR A 311
 None
 1.12A 6cduA-5l8sA:
undetectable
6cduB-5l8sA:
undetectable		 6cduA-5l8sA:
18.30
6cduB-5l8sA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5log PUTATIVE
O-METHYLTRANSFERASE

(Myxococcus
xanthus) 		PF01596
(Methyltransf_3) 		4 GLN A 105
VAL A 109
TRP A 104
THR A  77
 None
 1.35A 6cduA-5logA:
undetectable
6cduB-5logA:
undetectable		 6cduA-5logA:
21.57
6cduB-5logA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlv -

(-) 		no annotation 4 GLN G 141
VAL G 128
PRO G 144
THR G 434
 None
 1.37A 6cduA-5mlvG:
undetectable
6cduB-5mlvG:
undetectable		 6cduA-5mlvG:
undetectable
6cduB-5mlvG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpd 26S PROTEASOME
REGULATORY SUBUNIT
RPN9
26S PROTEASOME
REGULATORY SUBUNIT
RPN5
26S PROTEASOME
REGULATORY SUBUNIT
RPN8

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF01399
(PCI)
PF01399
(PCI)
PF01398
(JAB)
PF13012
(MitMem_reg) 		4 GLN U 230
VAL U 232
PRO O 355
THR P 428
 None
 1.45A 6cduA-5mpdU:
undetectable
6cduB-5mpdU:
undetectable		 6cduA-5mpdU:
21.01
6cduB-5mpdU:
21.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5o8f GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-3,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT
ALPHA-5,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-5

(Homo sapiens) 		no annotation 4 GLN A 245
VAL A 246
TRP A 249
PRO A 403
 None
 0.34A 6cduA-5o8fA:
28.6
6cduB-5o8fA:
20.8		 6cduA-5o8fA:
48.09
6cduB-5o8fA:
48.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9w THEBAINE
6-O-DEMETHYLASE

(Papaver
somniferum) 		no annotation 4 GLN A  89
VAL A 276
PRO A 269
THR A 310
 None
 0.90A 6cduA-5o9wA:
undetectable
6cduB-5o9wA:
undetectable		 6cduA-5o9wA:
undetectable
6cduB-5o9wA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5osb PROTON-GATED ION
CHANNEL,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1

(Mus musculus;
Gloeobacter
violaceus) 		no annotation 4 GLN A 241
VAL A 242
TRP A 245
PRO A 400
 A8Z  A 502 (-2.8A)
A8Z  A 502 (-2.9A)
A8Z  A 502 ( 2.8A)
A8Z  A 502 (-3.1A)
 0.36A 6cduA-5osbA:
27.0
6cduB-5osbA:
20.4		 6cduA-5osbA:
49.40
6cduB-5osbA:
49.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ubk ACYL-HOMOSERINE
LACTONE ACYLASE PVDQ

(Pseudomonas
aeruginosa) 		PF01804
(Penicil_amidase) 		4 GLN A 703
VAL A 697
TRP A 186
THR A 692
 None
 1.48A 6cduA-5ubkA:
undetectable
6cduB-5ubkA:
undetectable		 6cduA-5ubkA:
18.17
6cduB-5ubkA:
18.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xmb PANTOTHENATE KINASE

(Mycobacterium
tuberculosis) 		no annotation 4 GLN A 207
VAL A 205
PRO A 150
THR A 127
 None
 1.19A 6cduA-5xmbA:
undetectable
6cduB-5xmbA:
undetectable		 6cduA-5xmbA:
undetectable
6cduB-5xmbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zfh KALLIKREIN-7

(Mus musculus) 		no annotation 4 GLN A  30
VAL A  45
TRP A  29
THR A 208
 None
 1.39A 6cduA-5zfhA:
undetectable
6cduB-5zfhA:
undetectable		 6cduA-5zfhA:
undetectable
6cduB-5zfhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6u GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1

(Homo sapiens) 		no annotation 4 GLN B 242
VAL B 243
TRP B 246
PRO B 330
 None
 1.23A 6cduA-6d6uB:
26.2
6cduB-6d6uB:
26.0		 6cduA-6d6uB:
undetectable
6cduB-6d6uB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dnh PRE-MRNA 3' END
PROCESSING PROTEIN
WDR33

(Homo sapiens) 		no annotation 4 VAL B 260
TRP B 273
PRO B 275
THR B 283
 None
 1.38A 6cduA-6dnhB:
undetectable
6cduB-6dnhB:
undetectable		 6cduA-6dnhB:
undetectable
6cduB-6dnhB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9n PRE-MRNA 3' END
PROCESSING PROTEIN
WDR33

(Homo sapiens) 		no annotation 4 VAL B 260
TRP B 273
PRO B 275
THR B 283
 None
 1.43A 6cduA-6f9nB:
undetectable
6cduB-6f9nB:
undetectable		 6cduA-6f9nB:
undetectable
6cduB-6f9nB:
undetectable