SIMILAR PATTERNS OF AMINO ACIDS FOR 6CCV_C_RFPC1205
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1tlq | HYPOTHETICAL PROTEINYPJQ (Bacillussubtilis) |
PF04608(PgpA) | 5 | GLN A 74ASP A 92LEU A 70PRO A 103ILE A 146 | None | 1.44A | 6ccvC-1tlqA:undetectable | 6ccvC-1tlqA:10.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2frv | PERIPLASMICHYDROGENASE (Desulfovibriogigas) |
no annotation | 5 | GLN L 417ASP L 107HIS L 108SER L 374ARG L 296 | None | 1.34A | 6ccvC-2frvL:undetectable | 6ccvC-2frvL:18.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2oap | TYPE II SECRETIONSYSTEM PROTEIN (Archaeoglobusfulgidus) |
PF00437(T2SSE) | 5 | ASP 1 141SER 1 207LEU 1 203ARG 1 187ILE 1 226 | None | 1.40A | 6ccvC-2oap1:undetectable | 6ccvC-2oap1:18.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2w9m | POLYMERASE X (Deinococcusradiodurans) |
PF14520(HHH_5)PF14716(HHH_8) | 5 | ASP A 516LEU A 442ARG A 441ARG A 494HIS A 334 | ZN A1566 (-2.5A)NoneNone ZN A1567 ( 4.8A) ZN A1566 (-3.5A) | 1.15A | 6ccvC-2w9mA:0.0 | 6ccvC-2w9mA:20.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2y4o | PHENYLACETATE-COENZYME A LIGASE (Burkholderiacenocepacia) |
PF00501(AMP-binding)PF14535(AMP-binding_C_2) | 5 | ASP A 197SER A 209LEU A 211ILE A 177HIS A 370 | None MG A1439 (-3.5A)NoneNoneNone | 1.45A | 6ccvC-2y4oA:0.0 | 6ccvC-2y4oA:18.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3bg9 | PYRUVATECARBOXYLASE,MITOCHONDRIAL (Homo sapiens) |
PF00682(HMGL-like)PF02436(PYC_OADA) | 5 | GLN A 807ASP A 742HIS A 771SER A 576LEU A 577 | NoneNone MN A2001 (-3.4A)NoneNone | 1.41A | 6ccvC-3bg9A:1.6 | 6ccvC-3bg9A:20.85 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3cux | MALATE SYNTHASE (Bacillusanthracis) |
PF01274(Malate_synthase) | 5 | GLN A 230ASP A 264HIS A 265LEU A 200PRO A 81 | None | 1.29A | 6ccvC-3cuxA:0.0 | 6ccvC-3cuxA:19.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3hkz | DNA-DIRECTED RNAPOLYMERASE SUBUNIT B (Sulfolobussolfataricus) |
PF00562(RNA_pol_Rpb2_6)PF04560(RNA_pol_Rpb2_7)PF04561(RNA_pol_Rpb2_2)PF04563(RNA_pol_Rpb2_1)PF04565(RNA_pol_Rpb2_3)PF04566(RNA_pol_Rpb2_4)PF04567(RNA_pol_Rpb2_5) | 5 | GLN B 412ASP B 415HIS B 425ARG B 428PRO B 459 | None | 1.12A | 6ccvC-3hkzB:22.0 | 6ccvC-3hkzB:29.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i6u | SERINE/THREONINE-PROTEIN KINASE CHK2 (Homo sapiens) |
PF00069(Pkinase)PF00498(FHA) | 5 | ASP A 368HIS A 371ARG A 249ILE A 251HIS A 345 | None | 1.39A | 6ccvC-3i6uA:0.0 | 6ccvC-3i6uA:17.25 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ig4 | XAA-PROAMINOPEPTIDASE (Bacillusanthracis) |
PF00557(Peptidase_M24)PF05195(AMP_N) | 5 | HIS A 339LEU A 293ARG A 403ILE A 368HIS A 239 | SO4 A 431 ( 4.3A)NoneNoneNoneSO4 A 431 ( 3.4A) | 1.14A | 6ccvC-3ig4A:0.6 | 6ccvC-3ig4A:17.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3os4 | NICOTINATEPHOSPHORIBOSYLTRANSFERASE (Yersinia pestis) |
PF04095(NAPRTase) | 5 | ASP A 108LEU A 353ARG A 137ILE A 129HIS A 103 | None | 1.28A | 6ccvC-3os4A:undetectable | 6ccvC-3os4A:16.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3rxy | NIF3 PROTEIN (Sphaerobacterthermophilus) |
no annotation | 5 | ASP A 251LEU A 130PRO A 135ILE A 132HIS A 247 | None | 1.45A | 6ccvC-3rxyA:undetectable | 6ccvC-3rxyA:14.66 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4pw1 | UNCHARACTERIZEDPROTEIN ([Clostridium]leptum) |
no annotation | 5 | GLN A 166ASP A 168SER A 248LEU A 50ILE A 255 | None | 1.18A | 6ccvC-4pw1A:undetectable | 6ccvC-4pw1A:12.52 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qiw | DNA-DIRECTED RNAPOLYMERASE (Thermococcuskodakarensis) |
PF00562(RNA_pol_Rpb2_6)PF04560(RNA_pol_Rpb2_7)PF04561(RNA_pol_Rpb2_2)PF04563(RNA_pol_Rpb2_1)PF04565(RNA_pol_Rpb2_3)PF04566(RNA_pol_Rpb2_4)PF04567(RNA_pol_Rpb2_5) | 5 | GLN B 425ASP B 428HIS B 438ARG B 441ARG B 448 | None | 1.44A | 6ccvC-4qiwB:28.0 | 6ccvC-4qiwB:29.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qiw | DNA-DIRECTED RNAPOLYMERASE (Thermococcuskodakarensis) |
PF00562(RNA_pol_Rpb2_6)PF04560(RNA_pol_Rpb2_7)PF04561(RNA_pol_Rpb2_2)PF04563(RNA_pol_Rpb2_1)PF04565(RNA_pol_Rpb2_3)PF04566(RNA_pol_Rpb2_4)PF04567(RNA_pol_Rpb2_5) | 5 | GLN B 425ASP B 428HIS B 438ARG B 441PRO B 472 | None | 0.77A | 6ccvC-4qiwB:28.0 | 6ccvC-4qiwB:29.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qnn | PHOSPHOLIPASE A 1 FROM HORNET(VESPABASALIS) VENOM (Vespa basalis) |
PF00151(Lipase) | 5 | ASP A 81HIS A 51SER A 143LEU A 133ILE A 113 | None | 1.49A | 6ccvC-4qnnA:undetectable | 6ccvC-4qnnA:13.37 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r7z | CELL DIVISIONCONTROL PROTEIN 21 (Pyrococcusfuriosus) |
PF00493(MCM) | 5 | ASP A 321ARG A 879PRO A 346ILE A 875HIS A 323 | None | 1.34A | 6ccvC-4r7zA:undetectable | 6ccvC-4r7zA:15.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4wbt | PROBABLEHISTIDINOL-PHOSPHATEAMINOTRANSFERASE (Sinorhizobiummeliloti) |
PF00155(Aminotran_1_2) | 5 | ASP A 329SER A 296LEU A 298ILE A 367ARG A 325 | None | 1.43A | 6ccvC-4wbtA:undetectable | 6ccvC-4wbtA:15.83 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jbg | LGP2 (Gallus gallus) |
PF00271(Helicase_C)PF04851(ResIII)PF11648(RIG-I_C-RD) | 5 | GLN A 418SER A 435LEU A 401ILE A 369HIS A 134 | U X 22 ( 4.4A)NoneNoneNoneNone | 1.42A | 6ccvC-5jbgA:undetectable | 6ccvC-5jbgA:21.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kar | ACIDSPHINGOMYELINASE-LIKE PHOSPHODIESTERASE3B (Mus musculus) |
PF00149(Metallophos) | 5 | ASP A 28SER A 74LEU A 75ILE A 322HIS A 236 | ZN A 502 (-3.0A)NoneNoneNone ZN A 501 (-3.3A) | 1.46A | 6ccvC-5karA:0.4 | 6ccvC-5karA:16.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kis | RHS2 (Yersiniaentomophaga) |
no annotation | 5 | GLN B 473GLN B 652ARG B 657LEU B 449ILE B 438 | None | 1.40A | 6ccvC-5kisB:1.8 | 6ccvC-5kisB:22.51 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5tw1 | DNA-DIRECTED RNAPOLYMERASE SUBUNITBETA (Mycolicibacteriumsmegmatis) |
PF00562(RNA_pol_Rpb2_6)PF04560(RNA_pol_Rpb2_7)PF04561(RNA_pol_Rpb2_2)PF04563(RNA_pol_Rpb2_1)PF04565(RNA_pol_Rpb2_3)PF10385(RNA_pol_Rpb2_45) | 11 | GLN C 426GLN C 429ASP C 432HIS C 442ARG C 445SER C 447LEU C 449ARG C 456PRO C 480ILE C 488HIS C 671 | None | 0.81A | 6ccvC-5tw1C:49.5 | 6ccvC-5tw1C:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5tw1 | DNA-DIRECTED RNAPOLYMERASE SUBUNITBETA (Mycolicibacteriumsmegmatis) |
PF00562(RNA_pol_Rpb2_6)PF04560(RNA_pol_Rpb2_7)PF04561(RNA_pol_Rpb2_2)PF04563(RNA_pol_Rpb2_1)PF04565(RNA_pol_Rpb2_3)PF10385(RNA_pol_Rpb2_45) | 10 | GLN C 426GLN C 429ASP C 432HIS C 442ARG C 445SER C 447LEU C 449PRO C 480ILE C 488ARG C 604 | None | 1.40A | 6ccvC-5tw1C:49.5 | 6ccvC-5tw1C:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vyw | PYRUVATE CARBOXYLASE (Lactococcuslactis) |
PF00289(Biotin_carb_N)PF00682(HMGL-like)PF02436(PYC_OADA)PF02785(Biotin_carb_C)PF02786(CPSase_L_D2) | 5 | GLN A 768ASP A 704HIS A 732SER A 538LEU A 539 | NoneNone MN A1201 (-4.0A)NoneNone | 1.41A | 6ccvC-5vywA:1.8 | 6ccvC-5vywA:23.43 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5xog | DNA-DIRECTED RNAPOLYMERASE SUBUNITBETA (Komagataellaphaffii) |
PF00562(RNA_pol_Rpb2_6)PF04560(RNA_pol_Rpb2_7)PF04561(RNA_pol_Rpb2_2)PF04563(RNA_pol_Rpb2_1)PF04565(RNA_pol_Rpb2_3)PF04566(RNA_pol_Rpb2_4)PF04567(RNA_pol_Rpb2_5) | 5 | GLN B 474HIS B 487ARG B 490ARG B 497PRO B 521 | A P 7 ( 3.9A)None G P 8 ( 4.7A) A P 7 ( 4.9A) G P 8 ( 4.9A) | 0.83A | 6ccvC-5xogB:22.8 | 6ccvC-5xogB:26.09 |