SIMILAR PATTERNS OF AMINO ACIDS FOR 6CCV_C_RFPC1205

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tlq HYPOTHETICAL PROTEIN
YPJQ


(Bacillus
subtilis)
PF04608
(PgpA)
5 GLN A  74
ASP A  92
LEU A  70
PRO A 103
ILE A 146
None
1.44A 6ccvC-1tlqA:
undetectable
6ccvC-1tlqA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2frv PERIPLASMIC
HYDROGENASE


(Desulfovibrio
gigas)
no annotation 5 GLN L 417
ASP L 107
HIS L 108
SER L 374
ARG L 296
None
1.34A 6ccvC-2frvL:
undetectable
6ccvC-2frvL:
18.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oap TYPE II SECRETION
SYSTEM PROTEIN


(Archaeoglobus
fulgidus)
PF00437
(T2SSE)
5 ASP 1 141
SER 1 207
LEU 1 203
ARG 1 187
ILE 1 226
None
1.40A 6ccvC-2oap1:
undetectable
6ccvC-2oap1:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w9m POLYMERASE X

(Deinococcus
radiodurans)
PF14520
(HHH_5)
PF14716
(HHH_8)
5 ASP A 516
LEU A 442
ARG A 441
ARG A 494
HIS A 334
ZN  A1566 (-2.5A)
None
None
ZN  A1567 ( 4.8A)
ZN  A1566 (-3.5A)
1.15A 6ccvC-2w9mA:
0.0
6ccvC-2w9mA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y4o PHENYLACETATE-COENZY
ME A LIGASE


(Burkholderia
cenocepacia)
PF00501
(AMP-binding)
PF14535
(AMP-binding_C_2)
5 ASP A 197
SER A 209
LEU A 211
ILE A 177
HIS A 370
None
MG  A1439 (-3.5A)
None
None
None
1.45A 6ccvC-2y4oA:
0.0
6ccvC-2y4oA:
18.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bg9 PYRUVATE
CARBOXYLASE,
MITOCHONDRIAL


(Homo sapiens)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
5 GLN A 807
ASP A 742
HIS A 771
SER A 576
LEU A 577
None
None
MN  A2001 (-3.4A)
None
None
1.41A 6ccvC-3bg9A:
1.6
6ccvC-3bg9A:
20.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cux MALATE SYNTHASE

(Bacillus
anthracis)
PF01274
(Malate_synthase)
5 GLN A 230
ASP A 264
HIS A 265
LEU A 200
PRO A  81
None
1.29A 6ccvC-3cuxA:
0.0
6ccvC-3cuxA:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT B


(Sulfolobus
solfataricus)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
5 GLN B 412
ASP B 415
HIS B 425
ARG B 428
PRO B 459
None
1.12A 6ccvC-3hkzB:
22.0
6ccvC-3hkzB:
29.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6u SERINE/THREONINE-PRO
TEIN KINASE CHK2


(Homo sapiens)
PF00069
(Pkinase)
PF00498
(FHA)
5 ASP A 368
HIS A 371
ARG A 249
ILE A 251
HIS A 345
None
1.39A 6ccvC-3i6uA:
0.0
6ccvC-3i6uA:
17.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ig4 XAA-PRO
AMINOPEPTIDASE


(Bacillus
anthracis)
PF00557
(Peptidase_M24)
PF05195
(AMP_N)
5 HIS A 339
LEU A 293
ARG A 403
ILE A 368
HIS A 239
SO4  A 431 ( 4.3A)
None
None
None
SO4  A 431 ( 3.4A)
1.14A 6ccvC-3ig4A:
0.6
6ccvC-3ig4A:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3os4 NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE


(Yersinia pestis)
PF04095
(NAPRTase)
5 ASP A 108
LEU A 353
ARG A 137
ILE A 129
HIS A 103
None
1.28A 6ccvC-3os4A:
undetectable
6ccvC-3os4A:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rxy NIF3 PROTEIN

(Sphaerobacter
thermophilus)
no annotation 5 ASP A 251
LEU A 130
PRO A 135
ILE A 132
HIS A 247
None
1.45A 6ccvC-3rxyA:
undetectable
6ccvC-3rxyA:
14.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pw1 UNCHARACTERIZED
PROTEIN


([Clostridium]
leptum)
no annotation 5 GLN A 166
ASP A 168
SER A 248
LEU A  50
ILE A 255
None
1.18A 6ccvC-4pw1A:
undetectable
6ccvC-4pw1A:
12.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE


(Thermococcus
kodakarensis)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
5 GLN B 425
ASP B 428
HIS B 438
ARG B 441
ARG B 448
None
1.44A 6ccvC-4qiwB:
28.0
6ccvC-4qiwB:
29.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qiw DNA-DIRECTED RNA
POLYMERASE


(Thermococcus
kodakarensis)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
5 GLN B 425
ASP B 428
HIS B 438
ARG B 441
PRO B 472
None
0.77A 6ccvC-4qiwB:
28.0
6ccvC-4qiwB:
29.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qnn PHOSPHOLIPASE A 1
FROM HORNET(VESPA
BASALIS) VENOM


(Vespa basalis)
PF00151
(Lipase)
5 ASP A  81
HIS A  51
SER A 143
LEU A 133
ILE A 113
None
1.49A 6ccvC-4qnnA:
undetectable
6ccvC-4qnnA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r7z CELL DIVISION
CONTROL PROTEIN 21


(Pyrococcus
furiosus)
PF00493
(MCM)
5 ASP A 321
ARG A 879
PRO A 346
ILE A 875
HIS A 323
None
1.34A 6ccvC-4r7zA:
undetectable
6ccvC-4r7zA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbt PROBABLE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE


(Sinorhizobium
meliloti)
PF00155
(Aminotran_1_2)
5 ASP A 329
SER A 296
LEU A 298
ILE A 367
ARG A 325
None
1.43A 6ccvC-4wbtA:
undetectable
6ccvC-4wbtA:
15.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jbg LGP2

(Gallus gallus)
PF00271
(Helicase_C)
PF04851
(ResIII)
PF11648
(RIG-I_C-RD)
5 GLN A 418
SER A 435
LEU A 401
ILE A 369
HIS A 134
U  X  22 ( 4.4A)
None
None
None
None
1.42A 6ccvC-5jbgA:
undetectable
6ccvC-5jbgA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kar ACID
SPHINGOMYELINASE-LIK
E PHOSPHODIESTERASE
3B


(Mus musculus)
PF00149
(Metallophos)
5 ASP A  28
SER A  74
LEU A  75
ILE A 322
HIS A 236
ZN  A 502 (-3.0A)
None
None
None
ZN  A 501 (-3.3A)
1.46A 6ccvC-5karA:
0.4
6ccvC-5karA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kis RHS2

(Yersinia
entomophaga)
no annotation 5 GLN B 473
GLN B 652
ARG B 657
LEU B 449
ILE B 438
None
1.40A 6ccvC-5kisB:
1.8
6ccvC-5kisB:
22.51
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA


(Mycolicibacterium
smegmatis)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45)
11 GLN C 426
GLN C 429
ASP C 432
HIS C 442
ARG C 445
SER C 447
LEU C 449
ARG C 456
PRO C 480
ILE C 488
HIS C 671
None
0.81A 6ccvC-5tw1C:
49.5
6ccvC-5tw1C:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA


(Mycolicibacterium
smegmatis)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45)
10 GLN C 426
GLN C 429
ASP C 432
HIS C 442
ARG C 445
SER C 447
LEU C 449
PRO C 480
ILE C 488
ARG C 604
None
1.40A 6ccvC-5tw1C:
49.5
6ccvC-5tw1C:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vyw PYRUVATE CARBOXYLASE

(Lactococcus
lactis)
PF00289
(Biotin_carb_N)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
5 GLN A 768
ASP A 704
HIS A 732
SER A 538
LEU A 539
None
None
MN  A1201 (-4.0A)
None
None
1.41A 6ccvC-5vywA:
1.8
6ccvC-5vywA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA


(Komagataella
phaffii)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5)
5 GLN B 474
HIS B 487
ARG B 490
ARG B 497
PRO B 521
A  P   7 ( 3.9A)
None
G  P   8 ( 4.7A)
A  P   7 ( 4.9A)
G  P   8 ( 4.9A)
0.83A 6ccvC-5xogB:
22.8
6ccvC-5xogB:
26.09