SIMILAR PATTERNS OF AMINO ACIDS FOR 6CBZ_B_ESTB602_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cj2 PROTEIN
(P-HYDROXYBENZOATE
HYDROXYLASE)

(Pseudomonas
fluorescens) 		PF01494
(FAD_binding_3) 		5 ALA A  59
GLU A  58
LEU A  20
ARG A 311
LEU A 109
 None
 1.42A 6cbzB-1cj2A:
undetectable		 6cbzB-1cj2A:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89

(Zoogloea
ramigera) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 ALA A 256
LEU A 258
MET A 259
ILE A 269
LEU A 272
 None
 1.42A 6cbzB-1dm3A:
undetectable		 6cbzB-1dm3A:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eys PHOTOSYNTHETIC
REACTION CENTER

(Thermochromatium
tepidum) 		PF00124
(Photo_RC) 		5 LEU L 246
ALA L 245
ILE L 237
HIS L 198
LEU L 195
 None
BPH  L 606 ( 4.9A)
None
None
None
 1.21A 6cbzB-1eysL:
undetectable		 6cbzB-1eysL:
14.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE

(Escherichia
coli) 		PF00982
(Glyco_transf_20) 		5 ALA A  11
GLU A  15
LEU A  28
ILE A 225
HIS A 154
 None
None
None
IMD  A 902 ( 4.3A)
IMD  A 902 (-3.9A)
 1.37A 6cbzB-1gz5A:
undetectable		 6cbzB-1gz5A:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h9m MOLYBDENUM-BINDING-P
ROTEIN

(Azotobacter
vinelandii) 		PF03459
(TOBE) 		5 LEU A  41
ALA A  23
GLU A  18
LEU A  16
LEU A 138
 None
 1.38A 6cbzB-1h9mA:
undetectable		 6cbzB-1h9mA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hfe PROTEIN (FE-ONLY
HYDROGENASE
(E.C.1.18.99.1)
(LARGER SUBUNIT))

(Desulfovibrio
vulgaris) 		PF02906
(Fe_hyd_lg_C)
PF13237
(Fer4_10) 		5 MET L 219
LEU L 210
ILE L 103
HIS L 141
LEU L 285
 None
 1.35A 6cbzB-1hfeL:
undetectable		 6cbzB-1hfeL:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i0a DELTA CRYSTALLIN I

(Meleagris
gallopavo) 		PF00206
(Lyase_1)
PF14698
(ASL_C2) 		5 LEU A  49
ALA A  46
LEU A  60
ILE A 100
LEU A  67
 None
 1.19A 6cbzB-1i0aA:
undetectable		 6cbzB-1i0aA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE

(Arabidopsis
thaliana) 		PF16363
(GDP_Man_Dehyd) 		5 LEU A  32
ALA A  31
MET A  85
ILE A  70
LEU A  44
 None
 1.38A 6cbzB-1n7gA:
undetectable		 6cbzB-1n7gA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n7g GDP-D-MANNOSE-4,6-DE
HYDRATASE

(Arabidopsis
thaliana) 		PF16363
(GDP_Man_Dehyd) 		5 LEU A 354
ALA A 355
GLU A 358
ILE A 229
LEU A 298
 None
 1.11A 6cbzB-1n7gA:
undetectable		 6cbzB-1n7gA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nkl NK-LYSIN

(Sus scrofa) 		PF05184
(SapB_1) 		5 MET A  49
GLU A  24
LEU A  61
ILE A  69
LEU A  14
 None
 1.01A 6cbzB-1nklA:
undetectable		 6cbzB-1nklA:
20.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 MET A 343
LEU A 349
ALA A 350
GLU A 353
LEU A 387
MET A 388
ARG A 394
ILE A 424
HIS A 524
LEU A 525
 EST  A   1 ( 4.0A)
EST  A   1 ( 4.8A)
EST  A   1 ( 3.7A)
EST  A   1 (-2.8A)
EST  A   1 (-4.0A)
None
EST  A   1 (-3.7A)
EST  A   1 ( 4.5A)
EST  A   1 (-3.8A)
EST  A   1 (-3.6A)
 0.28A 6cbzB-1pcgA:
37.3		 6cbzB-1pcgA:
97.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1skx ORPHAN NUCLEAR
RECEPTOR PXR

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 348
ALA A 345
LEU A 154
MET A 155
LEU A 373
 None
 1.34A 6cbzB-1skxA:
21.1		 6cbzB-1skxA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wgy RAP GUANINE
NUCLEOTIDE EXCHANGE
FACTOR 5

(Homo sapiens) 		no annotation 5 LEU A  50
ALA A  51
LEU A  92
ILE A  55
LEU A  64
 None
 1.45A 6cbzB-1wgyA:
undetectable		 6cbzB-1wgyA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wzz PROBABLE
ENDOGLUCANASE

(Komagataeibacter
xylinus) 		PF01270
(Glyco_hydro_8) 		5 LEU A 300
ALA A 301
GLU A 304
LEU A 314
ILE A  33
 None
 0.97A 6cbzB-1wzzA:
undetectable		 6cbzB-1wzzA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xb7 STEROID HORMONE
RECEPTOR ERR1

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 327
GLU A 331
LEU A 365
ARG A 372
HIS A 494
 None
 0.55A 6cbzB-1xb7A:
28.9		 6cbzB-1xb7A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xls RETINOIC ACID
RECEPTOR RXR-ALPHA

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 ALA A 272
LEU A 309
ARG A 316
ILE A 345
LEU A 436
 9CR  A 801 (-3.5A)
9CR  A 801 (-4.2A)
9CR  A 801 (-2.6A)
9CR  A 801 ( 4.5A)
9CR  A 801 (-4.7A)
 1.04A 6cbzB-1xlsA:
25.6		 6cbzB-1xlsA:
18.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bdq COPPER HOMEOSTASIS
PROTEIN CUTC

(Streptococcus
agalactiae) 		PF03932
(CutC) 		5 ALA A 115
GLU A  79
LEU A  83
ARG A  76
ILE A  43
 None
 1.47A 6cbzB-2bdqA:
undetectable		 6cbzB-2bdqA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cjq RNA-DIRECTED RNA
POLYMERASE

(Pestivirus A) 		PF00998
(RdRP_3) 		5 LEU A 358
LEU A 417
MET A 416
ARG A 403
LEU A 189
 None
 1.27A 6cbzB-2cjqA:
undetectable		 6cbzB-2cjqA:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ckh SENTRIN-SPECIFIC
PROTEASE 1

(Homo sapiens) 		PF02902
(Peptidase_C48) 		5 MET A 604
ALA A 610
LEU A 478
MET A 477
ILE A 637
 None
 1.37A 6cbzB-2ckhA:
undetectable		 6cbzB-2ckhA:
16.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epg HYPOTHETICAL PROTEIN
TTHA1785

(Thermus
thermophilus) 		PF01139
(RtcB) 		5 LEU A  60
ALA A  61
LEU A  46
MET A  47
LEU A  35
 None
 1.27A 6cbzB-2epgA:
undetectable		 6cbzB-2epgA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fe1 CONSERVED
HYPOTHETICAL PROTEIN
PAE0151

(Pyrobaculum
aerophilum) 		PF01850
(PIN) 		5 LEU A  38
ALA A  39
GLU A  42
HIS A  34
LEU A  75
 None
 1.13A 6cbzB-2fe1A:
undetectable		 6cbzB-2fe1A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g7l TETR-FAMILY
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		5 ALA A  28
LEU A  66
ARG A  21
HIS A 107
LEU A  37
 None
 1.46A 6cbzB-2g7lA:
undetectable		 6cbzB-2g7lA:
16.74
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		6 LEU A 271
ALA A 272
GLU A 275
LEU A 309
ARG A 316
HIS A 434
 OHT  A 500 ( 4.4A)
OHT  A 500 (-3.5A)
OHT  A 500 (-2.6A)
OHT  A 500 ( 4.0A)
OHT  A 500 (-3.8A)
OHT  A 500 ( 4.7A)
 0.54A 6cbzB-2gpvA:
26.8		 6cbzB-2gpvA:
33.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hx0 PUTATIVE DNA-BINDING
PROTEIN

(Salmonella
enterica) 		PF03479
(DUF296) 		5 ALA A  40
GLU A 117
LEU A  37
ARG A 141
LEU A  28
 None
 1.29A 6cbzB-2hx0A:
undetectable		 6cbzB-2hx0A:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2it2 UPF0130 PROTEIN
PH1069

(Pyrococcus
horikoshii) 		PF02676
(TYW3) 		5 ALA A 125
LEU A 121
ILE A 144
HIS A 109
LEU A 108
 None
 1.31A 6cbzB-2it2A:
undetectable		 6cbzB-2it2A:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j4r EXOPOLYPHOSPHATASE

(Aquifex
aeolicus) 		PF02541
(Ppx-GppA) 		5 ALA A  96
GLU A  97
LEU A 100
ILE A  64
LEU A  45
 None
 1.41A 6cbzB-2j4rA:
undetectable		 6cbzB-2j4rA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jj7 HEMOLYSIN II
REGULATORY PROTEIN

(Bacillus cereus) 		PF00440
(TetR_N) 		5 LEU A  13
ALA A  16
LEU A  54
ILE A 118
LEU A 103
 None
 1.42A 6cbzB-2jj7A:
undetectable		 6cbzB-2jj7A:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k8v THIOREDOXIN
DOMAIN-CONTAINING
PROTEIN 12

(Homo sapiens) 		PF13899
(Thioredoxin_7) 		5 MET A 136
LEU A 143
LEU A 103
ILE A  45
HIS A  24
 None
 1.46A 6cbzB-2k8vA:
undetectable		 6cbzB-2k8vA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lf8 TRANSCRIPTION FACTOR
ETV6

(Mus musculus) 		PF00178
(Ets) 		5 LEU A 336
GLU A 434
MET A 390
ILE A 366
LEU A 344
 None
 1.46A 6cbzB-2lf8A:
undetectable		 6cbzB-2lf8A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mc3 MUS81 ENDONUCLEASE
HOMOLOG (YEAST),
ISOFORM CRA_B

(Homo sapiens) 		no annotation 5 LEU A  89
ALA A  90
LEU A  97
HIS A  22
LEU A  23
 None
 1.36A 6cbzB-2mc3A:
undetectable		 6cbzB-2mc3A:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o7p RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD

(Escherichia
coli) 		PF00383
(dCMP_cyt_deam_1)
PF01872
(RibD_C) 		5 GLU A 167
LEU A 204
ARG A 207
ILE A 228
LEU A 191
 None
 1.47A 6cbzB-2o7pA:
undetectable		 6cbzB-2o7pA:
13.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 MET A 343
LEU A 349
ALA A 350
GLU A 353
LEU A 387
MET A 388
ARG A 394
ILE A 424
HIS A 524
LEU A 525
 EST  A 596 (-4.8A)
EST  A 596 ( 4.1A)
EST  A 596 ( 3.9A)
EST  A 596 (-2.7A)
EST  A 596 ( 4.2A)
None
EST  A 596 (-4.0A)
EST  A 596 ( 4.7A)
EST  A 596 (-4.2A)
EST  A 596 (-3.6A)
 0.36A 6cbzB-2ocfA:
36.8		 6cbzB-2ocfA:
98.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfb CYTOCHROME P450

(Picrophilus
torridus) 		PF00067
(p450) 		5 LEU A 309
ALA A 310
GLU A 313
ILE A 241
LEU A 235
 HEM  A 410 ( 4.5A)
HEM  A 410 ( 3.7A)
None
HEM  A 410 (-4.5A)
None
 1.33A 6cbzB-2rfbA:
2.6		 6cbzB-2rfbA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rfb CYTOCHROME P450

(Picrophilus
torridus) 		PF00067
(p450) 		5 LEU A 318
ALA A 314
LEU A 205
ILE A 104
LEU A 111
 None
None
HEM  A 410 ( 4.0A)
None
None
 1.39A 6cbzB-2rfbA:
2.6		 6cbzB-2rfbA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE

(Streptococcus
sp.) 		PF01266
(DAO)
PF16901
(DAO_C) 		5 LEU A 143
ALA A 163
LEU A 103
MET A 102
ILE A  68
 None
 1.35A 6cbzB-2rghA:
undetectable		 6cbzB-2rghA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x1m METHIONYL-TRNA
SYNTHETASE

(Mycolicibacterium
smegmatis) 		PF09334
(tRNA-synt_1g) 		5 LEU A 365
ALA A 361
LEU A 476
ILE A 460
LEU A 420
 None
 1.36A 6cbzB-2x1mA:
undetectable		 6cbzB-2x1mA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c3w TWO COMPONENT
TRANSCRIPTIONAL
REGULATORY PROTEIN
DEVR

(Mycobacterium
tuberculosis) 		PF00072
(Response_reg)
PF00196
(GerE) 		5 LEU A  79
ALA A  51
LEU A  76
ILE A 106
LEU A  65
 None
 1.16A 6cbzB-3c3wA:
undetectable		 6cbzB-3c3wA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csk PROBABLE
DIPEPTIDYL-PEPTIDASE
3

(Saccharomyces
cerevisiae) 		PF03571
(Peptidase_M49) 		5 LEU A  63
ALA A  64
ARG A  45
ILE A 162
LEU A 122
 None
 1.41A 6cbzB-3cskA:
undetectable		 6cbzB-3cskA:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dbi SUGAR-BINDING
TRANSCRIPTIONAL
REGULATOR, LACI
FAMILY

(Escherichia
coli) 		PF13377
(Peripla_BP_3) 		5 ALA A 172
GLU A 175
LEU A 327
ILE A 295
HIS A 165
 None
 1.31A 6cbzB-3dbiA:
undetectable		 6cbzB-3dbiA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f6t ASPARTATE
AMINOTRANSFERASE

(Lactobacillus
acidophilus) 		PF00155
(Aminotran_1_2) 		5 MET A 305
LEU A 247
ALA A 246
ILE A 176
LEU A 183
 None
 1.17A 6cbzB-3f6tA:
undetectable		 6cbzB-3f6tA:
10.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fd5 SELENIDE, WATER
DIKINASE 1

(Homo sapiens) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 ALA A 155
GLU A 154
LEU A 247
ARG A 101
LEU A 111
 None
 1.33A 6cbzB-3fd5A:
undetectable		 6cbzB-3fd5A:
13.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hbj FLAVONOID
3-O-GLUCOSYLTRANSFER
ASE

(Medicago
truncatula) 		PF00201
(UDPGT) 		5 LEU A  19
ALA A  20
LEU A  30
ILE A  69
LEU A  58
 None
 1.33A 6cbzB-3hbjA:
undetectable		 6cbzB-3hbjA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hig AMILORIDE-SENSITIVE
AMINE OXIDASE

(Homo sapiens) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		5 LEU A  75
ALA A  97
GLU A  96
MET A 125
ILE A 101
 None
 0.91A 6cbzB-3higA:
undetectable		 6cbzB-3higA:
8.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iyl VP1

(Aquareovirus C) 		PF06016
(Reovirus_L2) 		5 LEU W  93
ALA W  92
LEU W  34
ILE W 131
LEU W 126
 None
 1.27A 6cbzB-3iylW:
undetectable		 6cbzB-3iylW:
5.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jys SUSD SUPERFAMILY
PROTEIN

(Bacteroides
vulgatus) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 LEU A 263
ALA A 264
GLU A 284
LEU A 270
ILE A 359
 None
 1.32A 6cbzB-3jysA:
undetectable		 6cbzB-3jysA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k31 ENOYL-(ACYL-CARRIER-
PROTEIN) REDUCTASE

(Anaplasma
phagocytophilum) 		PF13561
(adh_short_C2) 		5 ALA A  71
GLU A  72
MET A  77
ILE A  15
HIS A  93
 EDO  A 400 (-3.6A)
None
None
None
None
 1.10A 6cbzB-3k31A:
undetectable		 6cbzB-3k31A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lg5 EPI-ISOZIZAENE
SYNTHASE

(Streptomyces
coelicolor) 		no annotation 5 LEU A 193
ALA A 171
GLU A 175
ILE A 202
HIS A 164
 None
None
MG  A 700 ( 3.9A)
None
SO4  A 705 (-3.9A)
 1.24A 6cbzB-3lg5A:
undetectable		 6cbzB-3lg5A:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ln3 DIHYDRODIOL
DEHYDROGENASE

(Mus musculus) 		PF00248
(Aldo_ket_red) 		5 ALA A 218
LEU A 260
ILE A  16
HIS A  48
LEU A  19
 NAD  A 327 (-4.9A)
None
None
None
None
 1.39A 6cbzB-3ln3A:
undetectable		 6cbzB-3ln3A:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc1 PREDICTED
PHOSPHATASE, HAD
FAMILY

(Clostridium
acetobutylicum) 		PF13419
(HAD_2) 		5 LEU A 193
ALA A 196
GLU A 192
ILE A 146
LEU A 174
 None
 1.22A 6cbzB-3mc1A:
undetectable		 6cbzB-3mc1A:
17.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2b DIAMINOPIMELATE
DECARBOXYLASE

(Vibrio cholerae) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 ALA A 257
LEU A 241
ILE A  56
HIS A  54
LEU A 272
 None
 1.20A 6cbzB-3n2bA:
undetectable		 6cbzB-3n2bA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzp ARGININE
DECARBOXYLASE

(Campylobacter
jejuni) 		PF02784
(Orn_Arg_deC_N) 		5 ALA A 251
GLU A 250
LEU A 186
ILE A 238
LEU A 271
 None
 1.22A 6cbzB-3nzpA:
undetectable		 6cbzB-3nzpA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rio PTSGHI OPERON
ANTITERMINATOR

(Bacillus
subtilis) 		PF00874
(PRD)
PF03123
(CAT_RBD) 		5 MET A 143
LEU A 152
GLU A 156
ILE A  85
HIS A  84
 None
 1.43A 6cbzB-3rioA:
undetectable		 6cbzB-3rioA:
18.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rrv ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		5 MET A   4
ALA A  39
GLU A  91
MET A  96
ARG A  98
 None
 1.47A 6cbzB-3rrvA:
undetectable		 6cbzB-3rrvA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s8i PROTEIN DDI1 HOMOLOG
1

(Homo sapiens) 		PF09668
(Asp_protease) 		5 ALA A 263
LEU A 329
MET A 328
ILE A 246
LEU A 335
 None
 1.44A 6cbzB-3s8iA:
undetectable		 6cbzB-3s8iA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w0k BIFUNCTIONAL
ENDOMANNANASE/ENDOGL
UCANASE

(Caldanaerobius
polysaccharolyticus) 		PF00150
(Cellulase) 		5 ALA A  86
LEU A  83
ILE A 173
HIS A 151
LEU A 154
 None
 1.42A 6cbzB-3w0kA:
undetectable		 6cbzB-3w0kA:
11.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wrt BETA-LACTAMASE

(Chromohalobacter
sp. 560) 		PF00144
(Beta-lactamase) 		5 LEU A  77
ALA A  78
GLU A  81
LEU A 167
LEU A 159
 None
 1.28A 6cbzB-3wrtA:
undetectable		 6cbzB-3wrtA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b99 MITOGEN-ACTIVATED
PROTEIN KINASE 7

(Homo sapiens) 		PF00069
(Pkinase) 		5 MET A 327
LEU A 321
ALA A 320
ILE A 251
LEU A 163
 None
 1.38A 6cbzB-4b99A:
undetectable		 6cbzB-4b99A:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		5 LEU B3056
ALA B3055
LEU B3179
ILE B3114
LEU B3109
 None
 1.40A 6cbzB-4bedB:
undetectable		 6cbzB-4bedB:
3.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bh6 APC/C ACTIVATOR
PROTEIN CDH1

(Saccharomyces
cerevisiae) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		5 LEU A 277
ALA A 278
LEU A 308
HIS A 297
LEU A 298
 None
 1.41A 6cbzB-4bh6A:
undetectable		 6cbzB-4bh6A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d9i DIAMINOPROPIONATE
AMMONIA-LYASE

(Escherichia
coli) 		PF00291
(PALP) 		5 ALA A 213
GLU A 212
ARG A  70
ILE A 334
LEU A  63
 None
 1.33A 6cbzB-4d9iA:
undetectable		 6cbzB-4d9iA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dqd EXTRACELLULAR
LIGAND-BINDING
RECEPTOR

(Rhodopseudomonas
palustris) 		PF13458
(Peripla_BP_6) 		5 MET A 114
LEU A 102
ALA A 106
LEU A  82
ILE A  27
 None
 1.20A 6cbzB-4dqdA:
undetectable		 6cbzB-4dqdA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4evi CONIFERYL ALCOHOL
9-O-METHYLTRANSFERAS
E

(Linum
nodiflorum) 		PF00891
(Methyltransf_2)
PF08100
(Dimerisation) 		5 LEU A  35
ALA A  32
LEU A  74
MET A  73
ILE A  24
 None
 1.27A 6cbzB-4eviA:
undetectable		 6cbzB-4eviA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hzu ENERGY-COUPLING
FACTOR TRANSPORTER
TRANSMEMBRANE
PROTEIN ECFT
PREDICTED MEMBRANE
PROTEIN

(Lactobacillus
brevis) 		PF02361
(CbiQ)
PF07155
(ECF-ribofla_trS) 		5 ALA T 175
GLU T 174
LEU T 208
ARG T 215
LEU S  39
 None
 1.33A 6cbzB-4hzuT:
2.1		 6cbzB-4hzuT:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv5 ASPARTATE
CARBAMOYLTRANSFERASE
, PUTATIVE

(Trypanosoma
cruzi) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 ALA A 123
GLU A 122
LEU A  96
ARG A 116
LEU A 110
 None
 1.37A 6cbzB-4iv5A:
undetectable		 6cbzB-4iv5A:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1j NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 14

(Homo sapiens) 		PF02758
(PYRIN) 		5 ALA A  53
GLU A  49
LEU A  61
ILE A  78
LEU A  19
 None
 1.46A 6cbzB-4n1jA:
undetectable		 6cbzB-4n1jA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1j NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 14

(Homo sapiens) 		PF02758
(PYRIN) 		5 ALA A  53
GLU A  49
LEU A  61
MET A  62
ILE A  78
 None
 1.32A 6cbzB-4n1jA:
undetectable		 6cbzB-4n1jA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1j NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 14

(Homo sapiens) 		PF02758
(PYRIN) 		5 ALA A  53
GLU A  49
MET A  62
ILE A  78
LEU A  27
 None
 1.29A 6cbzB-4n1jA:
undetectable		 6cbzB-4n1jA:
26.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		6 LEU A 286
ALA A 287
GLU A 290
LEU A 324
ARG A 331
ILE A 361
 None
 0.53A 6cbzB-4n1yA:
31.1		 6cbzB-4n1yA:
28.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n2x DL-2-HALOACID
DEHALOGENASE

(Methylobacterium
sp. CPA1) 		PF10778
(DehI) 		5 ALA A  68
GLU A  69
ARG A  76
ILE A 124
LEU A  59
 None
 1.48A 6cbzB-4n2xA:
undetectable		 6cbzB-4n2xA:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n8g TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Chromohalobacter
salexigens) 		PF03480
(DctP) 		5 LEU A  56
ALA A 270
GLU A 269
LEU A 273
HIS A  47
 None
 1.29A 6cbzB-4n8gA:
undetectable		 6cbzB-4n8gA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nq1 4-HYDROXY-TETRAHYDRO
DIPICOLINATE
SYNTHASE

(Legionella
pneumophila) 		PF00701
(DHDPS) 		5 MET A 213
LEU A 219
ALA A 220
LEU A 195
HIS A 239
 None
 1.38A 6cbzB-4nq1A:
undetectable		 6cbzB-4nq1A:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q5n GLUTHATIONE
S-TRANSFERASE BLO T
8 ISOFORM

(Blomia
tropicalis) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		5 MET A  90
GLU A 105
LEU A 171
HIS A  24
LEU A  21
 None
 1.39A 6cbzB-4q5nA:
undetectable		 6cbzB-4q5nA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q69 PUTATIVE LIPOPROTEIN

(Bacteroides
thetaiotaomicron) 		PF12771
(SusD-like_2) 		5 MET A 203
LEU A 209
ALA A 210
LEU A 177
ILE A 127
 None
 1.21A 6cbzB-4q69A:
undetectable		 6cbzB-4q69A:
11.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rm9 EZRIN

(Homo sapiens) 		PF00373
(FERM_M)
PF00769
(ERM)
PF09379
(FERM_N)
PF09380
(FERM_C) 		5 LEU A 223
ALA A 222
GLU A  87
ARG A 295
ILE A 248
 None
 1.37A 6cbzB-4rm9A:
undetectable		 6cbzB-4rm9A:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u98 MALTOKINASE

(Mycolicibacterium
vanbaalenii) 		PF01636
(APH) 		5 LEU A 406
ALA A 407
GLU A 410
HIS A 449
LEU A 447
 None
 1.08A 6cbzB-4u98A:
undetectable		 6cbzB-4u98A:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wny UNIVERSAL STRESS
PROTEIN

(Burkholderia
pseudomallei) 		PF00582
(Usp) 		5 LEU A  68
ALA A  71
LEU A   9
ILE A   5
LEU A  23
 None
 1.36A 6cbzB-4wnyA:
undetectable		 6cbzB-4wnyA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xrt STFQ
AROMATASE/CYCLASE

(Streptomyces
steffisburgensis) 		PF03364
(Polyketide_cyc) 		5 LEU A 126
ALA A 127
GLU A 130
ARG A  66
LEU A   9
 None
 1.46A 6cbzB-4xrtA:
undetectable		 6cbzB-4xrtA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zht BIFUNCTIONAL
UDP-N-ACETYLGLUCOSAM
INE
2-EPIMERASE/N-ACETYL
MANNOSAMINE KINASE

(Homo sapiens) 		PF02350
(Epimerase_2) 		5 LEU A 117
ALA A 118
LEU A  92
ILE A  75
LEU A  46
 None
 1.26A 6cbzB-4zhtA:
undetectable		 6cbzB-4zhtA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoh PUTATIVE
OXIDOREDUCTASE
MOLYBDOPTERIN-BINDIN
G SUBUNIT

(Sulfurisphaera
tokodaii) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		5 LEU A 171
ALA A 170
LEU A 228
ILE A 204
LEU A 191
 None
 1.06A 6cbzB-4zohA:
undetectable		 6cbzB-4zohA:
6.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 THE
ANAPHASE-PROMOTING
COMPLEX CHAIN R

(Homo sapiens) 		PF00400
(WD40)
PF12894
(ANAPC4_WD40) 		5 LEU R 201
ALA R 202
LEU R 232
HIS R 221
LEU R 222
 None
 1.41A 6cbzB-5a31R:
undetectable		 6cbzB-5a31R:
13.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ci5 EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY 1

(Pseudothermotoga
lettingae) 		PF13416
(SBP_bac_8) 		5 LEU A 223
ALA A 222
LEU A 197
ILE A 260
HIS A 285
 None
 1.42A 6cbzB-5ci5A:
undetectable		 6cbzB-5ci5A:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hfj ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA)

(Helicobacter
pylori) 		PF01555
(N6_N4_Mtase) 		5 LEU A 208
ALA A 204
GLU A 178
LEU A 174
LEU A 229
 None
 1.41A 6cbzB-5hfjA:
undetectable		 6cbzB-5hfjA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i01 PHOSPHOHEPTOSE
ISOMERASE

(Neisseria
gonorrhoeae) 		PF13580
(SIS_2) 		5 LEU A  36
ALA A  33
ILE A 119
HIS A 178
LEU A 181
 None
 1.37A 6cbzB-5i01A:
undetectable		 6cbzB-5i01A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iq0 ESTERASE

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 LEU A 213
ALA A 214
GLU A 217
ARG A  95
LEU A 195
 None
 1.34A 6cbzB-5iq0A:
undetectable		 6cbzB-5iq0A:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyv LUCIFERIN
4-MONOOXYGENASE

(Photinus
pyralis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A 238
ALA A 285
LEU A 287
ILE A 301
LEU A 333
 None
 1.28A 6cbzB-5kyvA:
undetectable		 6cbzB-5kyvA:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lc5 NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
3
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
6

(Bos taurus) 		PF00420
(Oxidored_q2)
PF00499
(Oxidored_q3)
PF00507
(Oxidored_q4) 		5 ALA K  68
GLU K  34
LEU A  63
ILE A  69
LEU J 161
 None
 1.22A 6cbzB-5lc5K:
undetectable		 6cbzB-5lc5K:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5p PRE-MRNA-SPLICING
HELICASE BRR2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		5 MET A1471
LEU A1446
ALA A1447
ILE A1465
LEU A1491
 None
 1.32A 6cbzB-5m5pA:
undetectable		 6cbzB-5m5pA:
3.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m99 ALPHA-AMYLASE

(Thermotoga
petrophila) 		PF00128
(Alpha-amylase) 		5 LEU B 338
LEU B 301
MET B 275
HIS B 316
LEU B 313
 None
 1.36A 6cbzB-5m99B:
undetectable		 6cbzB-5m99B:
11.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE
POTASSIUM-BINDING
SUBUNIT

(Escherichia
coli) 		PF03814
(KdpA) 		5 MET A 383
LEU A 389
ALA A 390
LEU A 530
ILE A 290
 None
 1.38A 6cbzB-5mrwA:
undetectable		 6cbzB-5mrwA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4l CERULOPLASMIN

(Rattus
norvegicus) 		no annotation 5 ALA A 277
LEU A 316
MET A 315
ILE A  26
LEU A 328
 None
None
None
None
CU  A1103 (-4.4A)
 1.33A 6cbzB-5n4lA:
undetectable		 6cbzB-5n4lA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nfh METHIONYL-TRNA
SYNTHETASE, PUTATIVE

(Trypanosoma
brucei) 		no annotation 5 LEU A 532
ALA A 529
LEU A 416
ILE A 542
HIS A 523
 None
None
None
None
MET  A 807 ( 4.7A)
 1.28A 6cbzB-5nfhA:
undetectable		 6cbzB-5nfhA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		10 MET A 295
LEU A 301
ALA A 302
GLU A 305
LEU A 339
MET A 340
ARG A 346
ILE A 376
HIS A 475
LEU A 476
 EST  A 601 ( 4.4A)
EST  A 601 ( 4.3A)
EST  A 601 ( 3.9A)
EST  A 601 (-2.4A)
EST  A 601 (-3.9A)
EST  A 601 ( 4.8A)
EST  A 601 (-4.1A)
EST  A 601 ( 4.4A)
EST  A 601 (-4.4A)
EST  A 601 (-3.5A)
 0.44A 6cbzB-5toaA:
31.4		 6cbzB-5toaA:
28.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u4h UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Acinetobacter
baumannii) 		PF00275
(EPSP_synthase) 		5 LEU A  96
GLU A 168
LEU A 195
ILE A  39
LEU A  34
 None
 1.11A 6cbzB-5u4hA:
undetectable		 6cbzB-5u4hA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux5 BIFUNCTIONAL PROTEIN
PROLINE UTILIZATION
A (PUTA)

(Corynebacterium
freiburgense) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		5 ALA A 625
GLU A 626
LEU A 644
ILE A 637
LEU A 600
 None
 1.33A 6cbzB-5ux5A:
undetectable		 6cbzB-5ux5A:
6.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vrd BIFUNCTIONAL
COENZYME PQQ
SYNTHESIS PROTEIN
C/D

(Methylobacterium
extorquens) 		no annotation 5 ALA D 153
LEU D 156
ARG D  91
HIS D  19
LEU D  22
 None
 1.27A 6cbzB-5vrdD:
undetectable		 6cbzB-5vrdD:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x87 BESTROPHIN

(Klebsiella
pneumoniae) 		no annotation 5 ALA A  82
GLU A  81
LEU A  85
ARG A 201
LEU A 272
 None
 1.39A 6cbzB-5x87A:
undetectable		 6cbzB-5x87A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3t RANBP-TYPE AND
C3HC4-TYPE ZINC
FINGER-CONTAINING
PROTEIN 1
SHARPIN

(Mus musculus) 		no annotation 5 LEU A  13
ALA A  12
GLU A   9
LEU C 206
MET C 207
 None
 1.23A 6cbzB-5y3tA:
undetectable		 6cbzB-5y3tA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6amn HEAT SHOCK PROTEIN
104

(Saccharomyces
cerevisiae) 		no annotation 5 ALA A  38
GLU A  41
LEU A  21
ILE A  76
LEU A  30
 None
 1.36A 6cbzB-6amnA:
undetectable		 6cbzB-6amnA:
18.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6day DIHYDROPTEROATE
SYNTHASE

(Xanthomonas
albilineans) 		no annotation 5 LEU A 220
ALA A 221
LEU A 260
ILE A 229
LEU A 206
 None
 1.48A 6cbzB-6dayA:
undetectable		 6cbzB-6dayA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dll P-HYDROXYBENZOATE
HYDROXYLASE

(Pseudomonas
putida) 		no annotation 5 ALA A  59
GLU A  58
LEU A  20
ARG A 311
LEU A 109
 None
 1.42A 6cbzB-6dllA:
undetectable		 6cbzB-6dllA:
23.86