SIMILAR PATTERNS OF AMINO ACIDS FOR 6CBZ_A_ESTA601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dkg MOLECULAR CHAPERONE
DNAK

(Escherichia
coli) 		PF00012
(HSP70) 		4 MET D 296
LEU D 283
LEU D 257
LEU D 252
 None
 1.07A 6cbzA-1dkgD:
undetectable		 6cbzA-1dkgD:
12.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eg3 DYSTROPHIN

(Homo sapiens) 		PF00397
(WW)
PF09068
(EF-hand_2)
PF09069
(EF-hand_3) 		4 LEU A 148
LEU A 179
ARG A  63
HIS A 136
 None
 1.01A 6cbzA-1eg3A:
undetectable		 6cbzA-1eg3A:
19.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fp3 N-ACYL-D-GLUCOSAMINE
2-EPIMERASE

(Sus scrofa) 		PF07221
(GlcNAc_2-epim) 		4 GLU A 190
LEU A 186
MET A 183
LEU A 215
 None
 1.24A 6cbzA-1fp3A:
undetectable		 6cbzA-1fp3A:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gsq GLUTATHIONE
S-TRANSFERASE

(Todarodes
pacificus) 		PF02798
(GST_N)
PF14497
(GST_C_3) 		4 MET A  64
LEU A  21
HIS A 155
LEU A 151
 None
 0.98A 6cbzA-1gsqA:
undetectable		 6cbzA-1gsqA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ka9 IMIDAZOLE GLYCEROL
PHOSPHATE SYNTHASE

(Thermus
thermophilus) 		PF00977
(His_biosynth) 		4 GLU F 116
LEU F  87
ARG F 110
LEU F  94
 None
 1.07A 6cbzA-1ka9F:
undetectable		 6cbzA-1ka9F:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nkl NK-LYSIN

(Sus scrofa) 		PF05184
(SapB_1) 		4 MET A  49
GLU A  24
LEU A  61
LEU A  14
 None
 0.98A 6cbzA-1nklA:
undetectable		 6cbzA-1nklA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nl3 PREPROTEIN
TRANSLOCASE SECA 1
SUBUNIT

(Mycobacterium
tuberculosis) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 MET A 648
ARG A 660
HIS A 782
LEU A 783
 None
 1.13A 6cbzA-1nl3A:
undetectable		 6cbzA-1nl3A:
6.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1pcg ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 MET A 343
LEU A 346
GLU A 353
LEU A 387
MET A 388
ARG A 394
HIS A 524
LEU A 525
 EST  A   1 ( 4.0A)
EST  A   1 (-4.4A)
EST  A   1 (-2.8A)
EST  A   1 (-4.0A)
None
EST  A   1 (-3.7A)
EST  A   1 (-3.8A)
EST  A   1 (-3.6A)
 0.26A 6cbzA-1pcgA:
36.9		 6cbzA-1pcgA:
98.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qfj PROTEIN (FLAVIN
REDUCTASE)

(Escherichia
coli) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 LEU A 122
ARG A  19
HIS A 158
LEU A 161
 None
 1.11A 6cbzA-1qfjA:
undetectable		 6cbzA-1qfjA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s3s P47 PROTEIN

(Rattus
norvegicus) 		PF00789
(UBX) 		4 GLU G 351
LEU G 339
MET G 340
LEU G 369
 None
 0.99A 6cbzA-1s3sG:
undetectable		 6cbzA-1s3sG:
24.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1taq TAQ DNA POLYMERASE

(Thermus
aquaticus) 		PF00476
(DNA_pol_A)
PF01367
(5_3_exonuc)
PF02739
(5_3_exonuc_N)
PF09281
(Taq-exonuc) 		4 LEU A 470
GLU A 530
LEU A 533
LEU A 484
 None
 1.22A 6cbzA-1taqA:
undetectable		 6cbzA-1taqA:
7.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wve 4-CRESOL
DEHYDROGENASE
[HYDROXYLATING]
FLAVOPROTEIN SUBUNIT

(Pseudomonas
putida) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		4 LEU A 284
LEU A 442
HIS A 418
LEU A 417
 None
 1.04A 6cbzA-1wveA:
undetectable		 6cbzA-1wveA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xb7 STEROID HORMONE
RECEPTOR ERR1

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 GLU A 331
LEU A 365
ARG A 372
LEU A 492
 None
 1.17A 6cbzA-1xb7A:
28.5		 6cbzA-1xb7A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xb7 STEROID HORMONE
RECEPTOR ERR1

(Homo sapiens) 		PF00104
(Hormone_recep) 		5 LEU A 324
GLU A 331
LEU A 365
ARG A 372
HIS A 494
 None
 0.49A 6cbzA-1xb7A:
28.5		 6cbzA-1xb7A:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zbt PEPTIDE CHAIN
RELEASE FACTOR 1

(Streptococcus
mutans) 		PF00472
(RF-1)
PF03462
(PCRF) 		4 LEU A 338
GLU A 340
LEU A 327
HIS A 184
 None
 1.16A 6cbzA-1zbtA:
undetectable		 6cbzA-1zbtA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b5d ALPHA-AMYLASE

(Thermotoga
maritima) 		PF03065
(Glyco_hydro_57)
PF09210
(DUF1957) 		4 LEU X 444
GLU X 509
MET X 504
LEU X 495
 None
 1.23A 6cbzA-2b5dX:
undetectable		 6cbzA-2b5dX:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bra NEDD9 INTERACTING
PROTEIN WITH
CALPONIN HOMOLOGY
AND LIM DOMAINS

(Mus musculus) 		PF01494
(FAD_binding_3) 		4 GLU A 102
LEU A 460
ARG A  70
LEU A 439
 None
 1.13A 6cbzA-2braA:
undetectable		 6cbzA-2braA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bxy MALTOOLIGOSYLTREHALO
SE TREHALOHYDROLASE

(Deinococcus
radiodurans) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48)
PF11941
(DUF3459) 		4 LEU A 430
LEU A 527
ARG A 530
LEU A 583
 None
 1.17A 6cbzA-2bxyA:
undetectable		 6cbzA-2bxyA:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c47 CASEIN KINASE 1
GAMMA 2 ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 311
GLU A 285
ARG A 292
LEU A 143
 None
 1.14A 6cbzA-2c47A:
undetectable		 6cbzA-2c47A:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cxn GLUCOSE-6-PHOSPHATE
ISOMERASE

(Mus musculus) 		PF00342
(PGI) 		4 LEU A  71
MET A  67
HIS A  17
LEU A  14
 None
 1.09A 6cbzA-2cxnA:
undetectable		 6cbzA-2cxnA:
8.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 GLU A 275
LEU A 309
ARG A 316
HIS A 434
 OHT  A 500 (-2.6A)
OHT  A 500 ( 4.0A)
OHT  A 500 (-3.8A)
OHT  A 500 ( 4.7A)
 0.61A 6cbzA-2gpvA:
27.5		 6cbzA-2gpvA:
33.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2gpv ESTROGEN-RELATED
RECEPTOR GAMMA

(Homo sapiens) 		PF00104
(Hormone_recep) 		4 LEU A 268
GLU A 275
LEU A 309
ARG A 316
 OHT  A 500 (-4.1A)
OHT  A 500 (-2.6A)
OHT  A 500 ( 4.0A)
OHT  A 500 (-3.8A)
 0.47A 6cbzA-2gpvA:
27.5		 6cbzA-2gpvA:
33.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i0e PROTEIN KINASE
C-BETA II

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 LEU A 530
LEU A 575
MET A 576
LEU A 535
 None
 1.24A 6cbzA-2i0eA:
undetectable		 6cbzA-2i0eA:
13.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i9d CHLORAMPHENICOL
ACETYLTRANSFERASE

(Bacteroides
thetaiotaomicron) 		PF00302
(CAT) 		4 GLU A 135
LEU A 143
MET A  85
LEU A 171
 None
 1.20A 6cbzA-2i9dA:
undetectable		 6cbzA-2i9dA:
18.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix8 ELONGATION FACTOR 3A

(Saccharomyces
cerevisiae) 		PF00005
(ABC_tran) 		4 MET A1390
LEU A1341
ARG A1166
LEU A1348
 None
 1.07A 6cbzA-2ix8A:
undetectable		 6cbzA-2ix8A:
6.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixf ANTIGEN PEPTIDE
TRANSPORTER 1

(Rattus
norvegicus) 		PF00005
(ABC_tran) 		4 LEU A 531
LEU A 528
HIS A 555
LEU A 554
 None
 1.07A 6cbzA-2ixfA:
undetectable		 6cbzA-2ixfA:
17.25
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2ocf ESTROGEN RECEPTOR

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 MET A 343
LEU A 346
GLU A 353
LEU A 387
MET A 388
ARG A 394
HIS A 524
LEU A 525
 EST  A 596 (-4.8A)
EST  A 596 (-4.4A)
EST  A 596 (-2.7A)
EST  A 596 ( 4.2A)
None
EST  A 596 (-4.0A)
EST  A 596 (-4.2A)
EST  A 596 (-3.6A)
 0.42A 6cbzA-2ocfA:
36.9		 6cbzA-2ocfA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0n HYPOTHETICAL PROTEIN
NMB1532

(Neisseria
meningitidis) 		PF01814
(Hemerythrin) 		4 LEU A  78
GLU A  70
LEU A  18
LEU A 156
 None
MN  A 604 (-2.5A)
None
None
 1.20A 6cbzA-2p0nA:
undetectable		 6cbzA-2p0nA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvw GLP_546_48378_50642

(Giardia
intestinalis) 		PF00636
(Ribonuclease_3)
PF02170
(PAZ) 		4 MET A 530
LEU A 533
LEU A 354
LEU A 490
 None
 1.25A 6cbzA-2qvwA:
undetectable		 6cbzA-2qvwA:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r44 UNCHARACTERIZED
PROTEIN

(Cytophaga
hutchinsonii) 		PF07726
(AAA_3) 		4 GLU A 189
LEU A 184
HIS A 180
LEU A 181
 None
PG4  A 342 (-4.2A)
None
PG4  A 342 ( 4.1A)
 1.09A 6cbzA-2r44A:
undetectable		 6cbzA-2r44A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r8q CLASS I
PHOSPHODIESTERASE
PDEB1

(Leishmania
major) 		PF00233
(PDEase_I) 		4 LEU A 906
LEU A 830
HIS A 822
LEU A 825
 None
 1.25A 6cbzA-2r8qA:
3.1		 6cbzA-2r8qA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a4r NFATC2-INTERACTING
PROTEIN

(Mus musculus) 		PF11976
(Rad60-SLD) 		4 LEU A 367
GLU A 395
LEU A 400
LEU A 341
 None
 1.22A 6cbzA-3a4rA:
undetectable		 6cbzA-3a4rA:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5k TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 1

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 GLU A  76
LEU A 234
MET A 235
LEU A 227
 None
 1.10A 6cbzA-3a5kA:
undetectable		 6cbzA-3a5kA:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bl9 SCAVENGER
MRNA-DECAPPING
ENZYME DCPS

(Homo sapiens) 		PF05652
(DcpS)
PF11969
(DcpS_C) 		4 LEU A 230
LEU A 298
HIS A 311
LEU A 305
 None
 1.12A 6cbzA-3bl9A:
undetectable		 6cbzA-3bl9A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c49 POLY(ADP-RIBOSE)
POLYMERASE 3

(Homo sapiens) 		PF00644
(PARP)
PF02877
(PARP_reg) 		4 MET A 285
LEU A 286
GLU A 234
HIS A 263
 None
 1.20A 6cbzA-3c49A:
undetectable		 6cbzA-3c49A:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c5w PP2A-SPECIFIC
METHYLESTERASE PME-1

(Homo sapiens) 		PF12697
(Abhydrolase_6) 		4 MET P 157
GLU P 129
HIS P 115
LEU P 112
 None
 0.94A 6cbzA-3c5wP:
undetectable		 6cbzA-3c5wP:
15.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kx2 PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE PRP43

(Saccharomyces
cerevisiae) 		no annotation 4 MET B 201
LEU B 472
LEU B 477
LEU B 467
 None
 1.19A 6cbzA-3kx2B:
undetectable		 6cbzA-3kx2B:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kye ROADBLOCK/LC7
DOMAIN, ROBL_LC7

(Streptomyces
avermitilis) 		PF03259
(Robl_LC7) 		4 LEU A  16
MET A  17
ARG A  23
LEU A 128
 None
 1.14A 6cbzA-3kyeA:
undetectable		 6cbzA-3kyeA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne5 CATION EFFLUX SYSTEM
PROTEIN CUSA

(Escherichia
coli) 		PF00873
(ACR_tran) 		4 GLU A 896
LEU A 945
MET A 944
LEU A 973
 None
 1.20A 6cbzA-3ne5A:
undetectable		 6cbzA-3ne5A:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ne5 CATION EFFLUX SYSTEM
PROTEIN CUSA

(Escherichia
coli) 		PF00873
(ACR_tran) 		4 LEU A  42
GLU A 471
LEU A 864
LEU A 673
 None
 1.27A 6cbzA-3ne5A:
undetectable		 6cbzA-3ne5A:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qd9 QSOX FROM
TRYPANOSOMA BRUCEI
(TBQSOX)

(Trypanosoma
brucei) 		PF00085
(Thioredoxin)
PF04777
(Evr1_Alr) 		4 LEU A 337
LEU A 251
HIS A 324
LEU A 323
 None
None
FAD  A 501 (-3.4A)
None
 1.28A 6cbzA-3qd9A:
undetectable		 6cbzA-3qd9A:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r79 UNCHARACTERIZED
PROTEIN

(Agrobacterium
fabrum) 		PF01168
(Ala_racemase_N) 		4 LEU A 132
GLU A 143
HIS A 175
LEU A 178
 None
 1.25A 6cbzA-3r79A:
undetectable		 6cbzA-3r79A:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rc0 N-LYSINE
METHYLTRANSFERASE
SETD6

(Homo sapiens) 		PF00856
(SET)
PF09273
(Rubis-subs-bind) 		4 LEU A 421
LEU A 416
HIS A 466
LEU A 465
 None
 0.85A 6cbzA-3rc0A:
undetectable		 6cbzA-3rc0A:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4l CAS3 METAL DEPENDENT
PHOSPHOHYDROLASE

(Methanocaldococcus
jannaschii) 		no annotation 4 LEU A 212
LEU A 118
HIS A  66
LEU A  62
 None
 1.28A 6cbzA-3s4lA:
undetectable		 6cbzA-3s4lA:
15.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s51 FANCONI ANEMIA GROUP
I PROTEIN HOMOLOG

(Mus musculus) 		PF14674
(FANCI_S1-cap)
PF14675
(FANCI_S1)
PF14676
(FANCI_S2)
PF14677
(FANCI_S3)
PF14678
(FANCI_S4)
PF14679
(FANCI_HD1)
PF14680
(FANCI_HD2) 		4 MET A 623
LEU A 626
LEU A 667
LEU A 674
 None
 0.84A 6cbzA-3s51A:
undetectable		 6cbzA-3s51A:
5.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3snx PUTATIVE SUSD-LIKE
CARBOHYDRATE BINDING
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		4 LEU A 143
LEU A 229
MET A 230
LEU A 207
 None
 0.84A 6cbzA-3snxA:
undetectable		 6cbzA-3snxA:
10.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t95 AUTOINDUCER
2-BINDING PROTEIN
LSRB

(Yersinia pestis) 		PF13407
(Peripla_BP_4) 		4 LEU A  55
GLU A  27
LEU A 282
MET A 281
 None
 1.21A 6cbzA-3t95A:
undetectable		 6cbzA-3t95A:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tka RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE H

(Escherichia
coli) 		PF01795
(Methyltransf_5) 		4 LEU A  19
LEU A  45
HIS A  37
LEU A  40
 None
None
SAM  A 400 (-3.8A)
None
 1.27A 6cbzA-3tkaA:
undetectable		 6cbzA-3tkaA:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3trc PHOSPHOENOLPYRUVATE-
PROTEIN
PHOSPHOTRANSFERASE

(Coxiella
burnetii) 		PF01590
(GAF) 		4 LEU A  26
LEU A  31
HIS A 151
LEU A 152
 None
 1.22A 6cbzA-3trcA:
undetectable		 6cbzA-3trcA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ua4 PROTEIN ARGININE
N-METHYLTRANSFERASE
5

(Caenorhabditis
elegans) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		4 LEU A 514
GLU A 512
LEU A 509
ARG A 695
 None
 1.11A 6cbzA-3ua4A:
undetectable		 6cbzA-3ua4A:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3up3 ACEDAF-12

(Ancylostoma
ceylanicum) 		PF00104
(Hormone_recep) 		4 LEU A 628
LEU A 598
MET A 597
LEU A 591
 None
 1.13A 6cbzA-3up3A:
19.6		 6cbzA-3up3A:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v1z ENDONUCLEASE
BSE634IR

(Geobacillus
stearothermophilus) 		PF07832
(Bse634I) 		4 LEU A 140
LEU A 216
HIS A 222
LEU A 124
 None
 1.20A 6cbzA-3v1zA:
undetectable		 6cbzA-3v1zA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsj 2-AMINO-5-CHLOROPHEN
OL 1,6-DIOXYGENASE
BETA SUBUNIT

(Comamonas
testosteroni) 		PF02900
(LigB) 		4 MET B 225
LEU B 228
GLU B 268
LEU B 241
 None
 0.88A 6cbzA-3vsjB:
undetectable		 6cbzA-3vsjB:
13.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gx8 DNA POLYMERASE III
SUBUNIT EPSILON,DNA
POLYMERASE III
SUBUNIT ALPHA

(Escherichia
coli) 		PF02811
(PHP) 		4 LEU A  79
LEU A  33
HIS A  53
LEU A  84
 None
 1.16A 6cbzA-4gx8A:
undetectable		 6cbzA-4gx8A:
16.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i8v CYTOCHROME P450 1A1

(Homo sapiens) 		PF00067
(p450) 		4 LEU A 433
LEU A 428
ARG A 338
LEU A 443
 None
 0.85A 6cbzA-4i8vA:
2.6		 6cbzA-4i8vA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENB

(Yersinia
entomophaga) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 LEU A1306
GLU A 763
MET A1269
LEU A 374
 None
 1.25A 6cbzA-4iglA:
undetectable		 6cbzA-4iglA:
4.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j7h EVAA 2,3-DEHYDRATASE

(Amycolatopsis
orientalis) 		PF03559
(Hexose_dehydrat) 		4 GLU A 399
LEU A 417
ARG A 393
LEU A 385
 None
None
EDO  A 504 (-4.3A)
None
 1.20A 6cbzA-4j7hA:
undetectable		 6cbzA-4j7hA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kc5 RHIE PROTEIN

(Paraburkholderia
rhizoxinica) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		4 GLU A3143
LEU A3257
MET A3258
HIS A3404
 None
 0.79A 6cbzA-4kc5A:
undetectable		 6cbzA-4kc5A:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lg8 PRE-MRNA-PROCESSING
FACTOR 19

(Homo sapiens) 		PF00400
(WD40) 		4 LEU A 238
LEU A 257
HIS A 217
LEU A 216
 None
 0.91A 6cbzA-4lg8A:
undetectable		 6cbzA-4lg8A:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lx1 UNCONVENTIONAL
MYOSIN-VA

(Homo sapiens) 		PF01843
(DIL) 		4 LEU A1781
LEU A1772
ARG A1809
LEU A1752
 None
 1.11A 6cbzA-4lx1A:
undetectable		 6cbzA-4lx1A:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mt0 MTRE PROTEIN

(Neisseria
gonorrhoeae) 		PF02321
(OEP) 		4 LEU A 258
GLU A 181
LEU A 260
LEU A  63
 None
 1.22A 6cbzA-4mt0A:
undetectable		 6cbzA-4mt0A:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mz0 CURL

(Moorea
producens) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 GLU A 795
LEU A 708
MET A 709
LEU A 701
 None
 1.14A 6cbzA-4mz0A:
undetectable		 6cbzA-4mz0A:
6.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n1y ESTROGEN RECEPTOR

(Crassostrea
gigas) 		PF00104
(Hormone_recep) 		4 LEU A 283
GLU A 290
LEU A 324
ARG A 331
 None
 0.42A 6cbzA-4n1yA:
31.8		 6cbzA-4n1yA:
28.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n8g TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Chromohalobacter
salexigens) 		PF03480
(DctP) 		4 GLU A 284
MET A 219
HIS A  47
LEU A  48
 None
 1.06A 6cbzA-4n8gA:
undetectable		 6cbzA-4n8gA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nle ADENYLOSUCCINATE
LYASE

(Mycolicibacterium
smegmatis) 		PF00206
(Lyase_1)
PF10397
(ADSL_C) 		4 GLU A 362
LEU A 267
ARG A 147
HIS A 284
 None
 1.16A 6cbzA-4nleA:
2.8		 6cbzA-4nleA:
9.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdv M7GPPPX
DIPHOSPHATASE

(Homo sapiens) 		PF05652
(DcpS)
PF11969
(DcpS_C) 		4 LEU A 230
LEU A 298
HIS A 311
LEU A 305
 None
None
PO4  A 403 (-4.0A)
None
 1.10A 6cbzA-4qdvA:
undetectable		 6cbzA-4qdvA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ra4 PROTEIN KINASE C

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		4 LEU A 527
LEU A 572
MET A 573
LEU A 532
 None
 1.23A 6cbzA-4ra4A:
undetectable		 6cbzA-4ra4A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uer EIF3A

(Lachancea
kluyveri) 		no annotation 4 GLU a 198
ARG a 156
HIS a 209
LEU a 206
 None
 1.27A 6cbzA-4uera:
undetectable		 6cbzA-4uera:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wqe THIOSULFATE
DEHYDROGENASE

(Allochromatium
vinosum) 		PF13442
(Cytochrome_CBB3) 		4 MET A 209
GLU A 221
LEU A 155
HIS A 164
 HEC  A1002 (-2.2A)
None
None
HEC  A1002 (-3.2A)
 0.91A 6cbzA-4wqeA:
undetectable		 6cbzA-4wqeA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wzs SIMILARITY TO
HELICASE MOT1

(Encephalitozoon
cuniculi) 		no annotation 4 LEU C 467
LEU C 462
HIS C 586
LEU C 587
 None
 1.12A 6cbzA-4wzsC:
undetectable		 6cbzA-4wzsC:
7.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xd9 RIBOSOME BIOGENESIS
PROTEIN, PUTATIVE
(AFU_ORTHOLOGUE
AFUA_8G04790)

(Aspergillus
nidulans) 		PF04427
(Brix) 		4 LEU A 206
LEU A 171
MET A 167
LEU A 101
 None
 1.00A 6cbzA-4xd9A:
undetectable		 6cbzA-4xd9A:
14.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y23 GAMMA GLUTAMYL
TRANSPEPTIDASE,GAMMA
-GLUTAMYLTRANSPEPTID
ASE

(Bacillus
licheniformis) 		PF01019
(G_glu_transpept) 		4 LEU A 421
GLU A  81
LEU A 183
LEU A 194
 None
 0.82A 6cbzA-4y23A:
undetectable		 6cbzA-4y23A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zu2 PUTATIVE
ISOHEXENYLGLUTACONYL
-COA HYDRATASE

(Pseudomonas
aeruginosa) 		PF00378
(ECH_1) 		4 LEU A  39
GLU A   7
LEU A  11
LEU A  55
 None
 1.22A 6cbzA-4zu2A:
undetectable		 6cbzA-4zu2A:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ahk ACETOLACTATE
SYNTHASE II, LARGE
SUBUNIT

(Pseudomonas
protegens) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 LEU A  71
LEU A  22
MET A  45
LEU A  81
 None
 1.15A 6cbzA-5ahkA:
undetectable		 6cbzA-5ahkA:
9.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d28 GM-CSF/IL-2
INHIBITION FACTOR

(Orf virus) 		no annotation 4 MET A 176
LEU A 179
LEU A 144
LEU A 137
 None
 1.22A 6cbzA-5d28A:
undetectable		 6cbzA-5d28A:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5djs TETRATRICOPEPTIDE
TPR_2 REPEAT PROTEIN

(Thermobaculum
terrenum) 		PF13181
(TPR_8)
PF13844
(Glyco_transf_41) 		4 LEU A 181
LEU A 214
ARG A 190
LEU A 207
 None
 0.84A 6cbzA-5djsA:
undetectable		 6cbzA-5djsA:
11.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dn6 ATP SYNTHASE SUBUNIT
ALPHA

(Paracoccus
denitrificans) 		PF00006
(ATP-synt_ab)
PF00306
(ATP-synt_ab_C)
PF02874
(ATP-synt_ab_N) 		4 MET A 243
LEU A 246
MET A 254
ARG A 309
 None
 1.28A 6cbzA-5dn6A:
undetectable		 6cbzA-5dn6A:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es9 LINEAR GRAMICIDIN
SYNTHETASE SUBUNIT A

(Brevibacillus
parabrevis) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00551
(Formyl_trans_N)
PF13193
(AMP-binding_C) 		4 LEU A 368
GLU A 373
LEU A 208
ARG A 376
 None
 1.19A 6cbzA-5es9A:
undetectable		 6cbzA-5es9A:
7.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ghe PESTICIDAL CRYSTAL
PROTEIN CRY6AA

(Bacillus
thuringiensis) 		no annotation 4 MET A 303
ARG A 203
HIS A  67
LEU A  64
 None
 0.98A 6cbzA-5gheA:
3.3		 6cbzA-5gheA:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5goo ALKALINE INVERTASE

(Nostoc sp. PCC
7120) 		PF12899
(Glyco_hydro_100) 		4 MET A 311
LEU A 314
GLU A 453
LEU A 136
 None
 1.27A 6cbzA-5gooA:
undetectable		 6cbzA-5gooA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvb WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1

(Homo sapiens) 		PF12341
(Mcl1_mid) 		4 MET A 725
LEU A 764
LEU A 787
MET A 788
 None
 1.12A 6cbzA-5gvbA:
undetectable		 6cbzA-5gvbA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h64 SERINE/THREONINE-PRO
TEIN KINASE MTOR

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08771
(FRB_dom)
PF11865
(DUF3385) 		4 MET A1512
LEU A1478
GLU A1451
LEU A1493
 None
 1.08A 6cbzA-5h64A:
undetectable		 6cbzA-5h64A:
3.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ja1 ENTEROBACTIN
BIOSYNTHESIS PROTEIN
YBDZ
ENTEROBACTIN
SYNTHASE COMPONENT F

(Escherichia
coli) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF00975
(Thioesterase)
PF03621
(MbtH)
PF13193
(AMP-binding_C) 		4 LEU A 819
GLU A 750
ARG A 866
LEU B  60
 None
None
75C  A1301 (-4.0A)
None
 0.99A 6cbzA-5ja1A:
undetectable		 6cbzA-5ja1A:
4.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kuc PESTICIDAL CRYSTAL
PROTEIN CRY6AA

(Bacillus
thuringiensis) 		no annotation 4 MET A 303
ARG A 203
HIS A  67
LEU A  64
 None
 1.03A 6cbzA-5kucA:
3.1		 6cbzA-5kucA:
13.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lpz PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00069
(Pkinase) 		4 GLU A 929
LEU A1033
ARG A 922
LEU A 997
 None
 1.22A 6cbzA-5lpzA:
undetectable		 6cbzA-5lpzA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mlv -

(-) 		no annotation 4 MET G 202
LEU G 219
LEU G 177
MET G 176
 None
 1.00A 6cbzA-5mlvG:
undetectable		 6cbzA-5mlvG:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnp N-TERMINAL
ACETYLTRANSFERASE-LI
KE PROTEIN
PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF00583
(Acetyltransf_1)
PF12569
(NARP1)
PF13432
(TPR_16) 		4 LEU A 221
GLU B 110
LEU B 106
HIS A 254
 None
 1.25A 6cbzA-5nnpA:
undetectable		 6cbzA-5nnpA:
7.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogs WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1

(Homo sapiens) 		no annotation 4 MET A 725
LEU A 764
LEU A 787
MET A 788
 None
 1.13A 6cbzA-5ogsA:
undetectable		 6cbzA-5ogsA:
10.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogx CYTOCHROME P450
REDUCTASE

(Amycolatopsis
methanolica) 		no annotation 4 LEU A 119
LEU A 180
HIS A 162
LEU A 161
 None
 1.13A 6cbzA-5ogxA:
undetectable		 6cbzA-5ogxA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5toa ESTROGEN RECEPTOR
BETA

(Homo sapiens) 		PF00104
(Hormone_recep) 		8 MET A 295
LEU A 298
GLU A 305
LEU A 339
MET A 340
ARG A 346
HIS A 475
LEU A 476
 EST  A 601 ( 4.4A)
EST  A 601 (-4.1A)
EST  A 601 (-2.4A)
EST  A 601 (-3.9A)
EST  A 601 ( 4.8A)
EST  A 601 (-4.1A)
EST  A 601 (-4.4A)
EST  A 601 (-3.5A)
 0.34A 6cbzA-5toaA:
31.6		 6cbzA-5toaA:
28.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vpq BETA-LACTAMASE

(Paraburkholderia
phymatum) 		PF13354
(Beta-lactamase2) 		4 LEU A 127
GLU A  81
LEU A  78
LEU A  67
 None
 1.28A 6cbzA-5vpqA:
undetectable		 6cbzA-5vpqA:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w3f TUBULIN ALPHA-1
CHAIN

(Saccharomyces
cerevisiae) 		PF00091
(Tubulin)
PF03953
(Tubulin_C) 		4 GLU A  27
LEU A  23
ARG A 244
LEU A 231
 None
 1.06A 6cbzA-5w3fA:
undetectable		 6cbzA-5w3fA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7l TSRD

(Streptomyces
laurentii) 		no annotation 4 MET A  47
LEU A   9
MET A  10
HIS A 117
 IPA  A 202 (-4.3A)
None
None
IPA  A 202 (-3.5A)
 1.22A 6cbzA-5x7lA:
undetectable		 6cbzA-5x7lA:
23.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xbp 3NT OXYGENASE BETA
SUBUNIT

(Diaphorobacter
sp. DS2) 		PF00866
(Ring_hydroxyl_B) 		4 GLU C  40
LEU C  37
HIS C 135
LEU C 134
 None
 1.27A 6cbzA-5xbpC:
undetectable		 6cbzA-5xbpC:
17.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3r DNA-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT

(Homo sapiens) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT)
PF02260
(FATC)
PF08163
(NUC194) 		4 MET C3858
LEU C3958
MET C3959
ARG C4090
 None
 1.14A 6cbzA-5y3rC:
undetectable		 6cbzA-5y3rC:
1.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y7o UGGT

(Thermomyces
dupontii) 		PF06427
(UDP-g_GGTase) 		4 LEU A 372
LEU A 938
ARG A 380
LEU A 966
 None
 1.26A 6cbzA-5y7oA:
undetectable		 6cbzA-5y7oA:
6.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y96 RECEPTOR-LIKE
PROTEIN KINASE
ANXUR1

(Arabidopsis
thaliana) 		no annotation 4 LEU B 210
GLU B 150
LEU B 100
ARG B 215
 None
 1.19A 6cbzA-5y96B:
undetectable		 6cbzA-5y96B:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z2e DIHYDRODIPICOLINATE
REDUCTASE

(Paenisporosarcina
sp. TG-14) 		no annotation 4 LEU A  63
ARG A   3
HIS A  84
LEU A  87
 None
 0.89A 6cbzA-5z2eA:
undetectable		 6cbzA-5z2eA:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fn1 HUMAN-MOUSE CHIMERIC
ABCB1 (ABCBHM)

(Homo sapiens) 		no annotation 4 GLU A 607
LEU A 614
MET A 615
LEU A 588
 None
 1.00A 6cbzA-6fn1A:
undetectable		 6cbzA-6fn1A:
24.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
4L

(Mus musculus) 		no annotation 4 LEU K  75
GLU K  70
LEU K  33
LEU K  26
 None
 0.85A 6cbzA-6g2jK:
undetectable		 6cbzA-6g2jK:
26.74