SIMILAR PATTERNS OF AMINO ACIDS FOR 6CBD_A_TRPA902_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ce7 PROTEIN
(RIBOSOME-INACTIVATI
NG PROTEIN TYPE II)

(Viscum album) 		PF00161
(RIP) 		4 VAL A  67
ALA A  78
PHE A  97
PHE A  52
 None
 1.29A 6cbdA-1ce7A:
undetectable		 6cbdA-1ce7A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cf5 PROTEIN
(BETA-MOMORCHARIN)

(Momordica
charantia) 		PF00161
(RIP) 		4 VAL A  62
ALA A  73
PHE A  95
PHE A  47
 None
 1.36A 6cbdA-1cf5A:
0.0		 6cbdA-1cf5A:
13.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uuo DIHYDROOROTATE
DEHYDROGENASE

(Rattus rattus) 		PF01180
(DHO_dh) 		4 VAL A 353
ALA A  95
PHE A 115
PHE A 113
 None
FMN  A1398 (-3.4A)
None
None
 1.36A 6cbdA-1uuoA:
2.0		 6cbdA-1uuoA:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fgt TWO-COMPONENT SYSTEM
YYCF/YYCG REGULATORY
PROTEIN YYCH

(Bacillus
subtilis) 		PF07435
(YycH) 		4 VAL A 340
ALA A 412
PHE A 334
PHE A 321
 None
 1.34A 6cbdA-2fgtA:
0.0		 6cbdA-2fgtA:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwu IMPORTIN13

(Homo sapiens) 		PF03810
(IBN_N)
PF08389
(Xpo1) 		4 VAL B 818
ALA B 822
PHE B 793
PHE B 779
 None
 1.49A 6cbdA-2xwuB:
0.3		 6cbdA-2xwuB:
22.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwb ENDOTHELIN-CONVERTIN
G ENZYME 1

(Homo sapiens) 		PF01431
(Peptidase_M13)
PF05649
(Peptidase_M13_N) 		4 VAL A 603
ALA A 677
PHE A 706
PHE A 598
 None
 1.25A 6cbdA-3dwbA:
0.0		 6cbdA-3dwbA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eoj BACTERIOCHLOROPHYLL
A PROTEIN

(Prosthecochloris
aestuarii) 		PF02327
(BChl_A) 		4 VAL A  63
ALA A  97
PHE A 243
PHE A  66
 EDO  A 392 (-4.7A)
BCL  A 376 (-3.6A)
BCL  A 375 (-4.4A)
BCL  A 375 (-4.6A)
 1.41A 6cbdA-3eojA:
0.0		 6cbdA-3eojA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6s SUBTILISIN-LIKE
PROTEASE

(Solanum
lycopersicum) 		PF00082
(Peptidase_S8) 		4 VAL A 442
ALA A 421
PHE A 437
PHE A 362
 None
 1.42A 6cbdA-3i6sA:
2.5		 6cbdA-3i6sA:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2d ABC-TYPE METAL ION
TRANSPORT SYSTEM,
PERIPLASMIC
COMPONENT

(Vibrio
vulnificus) 		PF03180
(Lipoprotein_9) 		4 VAL A  70
ALA A  74
PHE A  86
PHE A  66
 None
None
MET  A 266 (-4.9A)
None
 1.33A 6cbdA-3k2dA:
undetectable		 6cbdA-3k2dA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4y UNCHARACTERIZED
PROTEIN

(Desulfotomaculum
acetoxidans) 		PF10282
(Lactonase) 		4 VAL A  11
ALA A 317
PHE A  22
PHE A   8
 None
 1.45A 6cbdA-3u4yA:
undetectable		 6cbdA-3u4yA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u4y UNCHARACTERIZED
PROTEIN

(Desulfotomaculum
acetoxidans) 		PF10282
(Lactonase) 		4 VAL A  11
ALA A 317
PHE A  22
PHE A  21
 None
 1.48A 6cbdA-3u4yA:
undetectable		 6cbdA-3u4yA:
17.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3n MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRIPARTITE
MOTIF-CONTAINING
PROTEIN 5

(Escherichia
coli;
Macaca mulatta) 		PF00622
(SPRY)
PF01547
(SBP_bac_1) 		4 VAL A1352
ALA A1306
PHE A1383
PHE A1478
 None
 1.43A 6cbdA-4b3nA:
2.0		 6cbdA-4b3nA:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dmg PUTATIVE
UNCHARACTERIZED
PROTEIN TTHA1493

(Thermus
thermophilus) 		PF02475
(Met_10) 		4 VAL A  52
ALA A  42
PHE A  49
PHE A  68
 None
 1.46A 6cbdA-4dmgA:
1.1		 6cbdA-4dmgA:
18.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4krf PROTEIN ARGONAUTE-1

(Homo sapiens) 		PF02170
(PAZ)
PF02171
(Piwi)
PF08699
(ArgoL1)
PF16486
(ArgoN)
PF16487
(ArgoMid)
PF16488
(ArgoL2) 		4 VAL A 589
ALA A 618
PHE A 651
PHE A 657
 None
 0.18A 6cbdA-4krfA:
61.6		 6cbdA-4krfA:
82.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lec PROTEIN-LYSINE
METHYLTRANSFERASE
METTL21A

(Homo sapiens) 		PF10294
(Methyltransf_16) 		4 VAL A  52
ALA A  50
PHE A  26
PHE A  24
 None
SAH  A 301 (-3.3A)
None
None
 1.43A 6cbdA-4lecA:
2.3		 6cbdA-4lecA:
13.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oh7 ORNITHINE
CARBAMOYLTRANSFERASE

(Brucella
melitensis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 VAL A 172
ALA A 176
PHE A 180
PHE A 178
 None
 1.46A 6cbdA-4oh7A:
5.9		 6cbdA-4oh7A:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ovs TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Sulfurospirillum
deleyianum) 		PF03480
(DctP) 		4 VAL A 236
ALA A  85
PHE A  92
PHE A 135
 None
 1.44A 6cbdA-4ovsA:
undetectable		 6cbdA-4ovsA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qhq LIPOPROTEIN

(Burkholderia
cenocepacia) 		PF03180
(Lipoprotein_9) 		4 VAL A  69
ALA A  73
PHE A  85
PHE A  65
 None
None
MET  A 301 (-4.7A)
None
 1.48A 6cbdA-4qhqA:
1.8		 6cbdA-4qhqA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 1

(Homo sapiens) 		PF12859
(ANAPC1) 		4 VAL A1462
ALA A1466
PHE A1495
PHE A1491
 None
 1.44A 6cbdA-5a31A:
undetectable		 6cbdA-5a31A:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mvd DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL

(Homo sapiens) 		PF01180
(DHO_dh) 		4 VAL A 353
ALA A  95
PHE A 115
PHE A 113
 None
FMN  A 401 (-3.3A)
None
None
 1.34A 6cbdA-5mvdA:
undetectable		 6cbdA-5mvdA:
17.95
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5vm9 PROTEIN ARGONAUTE-3

(Homo sapiens) 		no annotation 4 VAL A 592
ALA A 621
PHE A 654
PHE A 660
 None
 0.52A 6cbdA-5vm9A:
57.5		 6cbdA-5vm9A:
79.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wea PROTEIN ARGONAUTE-2

(Homo sapiens) 		no annotation 4 VAL A 591
ALA A 620
PHE A 653
PHE A 659
 None
 0.27A 6cbdA-5weaA:
57.8		 6cbdA-5weaA:
undetectable