SIMILAR PATTERNS OF AMINO ACIDS FOR 6CB4_A_BEZA502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cau CANAVALIN

(Canavalia
ensiformis) 		PF00190
(Cupin_1) 		4 GLY B 263
LYS B 264
GLN B 287
ASN B 289
 None
 0.60A 6cb4A-1cauB:
13.3		 6cb4A-1cauB:
99.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgr CANAVALIN

(Canavalia
ensiformis) 		no annotation 4 GLY X 263
LYS X 264
GLN X 287
ASN X 289
 None
 0.37A 6cb4A-1dgrX:
3.9		 6cb4A-1dgrX:
27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qcx PECTIN LYASE B

(Aspergillus
niger) 		PF00544
(Pec_lyase_C) 		4 GLY A 119
LYS A 118
GLN A 115
ASN A 139
 None
 1.24A 6cb4A-1qcxA:
0.0		 6cb4A-1qcxA:
21.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2cav PROTEIN (CANAVALIN)

(Canavalia
ensiformis) 		PF00190
(Cupin_1) 		4 GLY A 263
LYS A 264
GLN A 287
ASN A 289
 None
 0.86A 6cb4A-2cavA:
51.3		 6cb4A-2cavA:
99.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bga BETA-GALACTOSIDASE

(Bacteroides
thetaiotaomicron) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N)
PF02929
(Bgal_small_N)
PF16353
(DUF4981) 		4 GLY A 835
LYS A 836
GLN A 838
ASN A 811
 None
 1.46A 6cb4A-3bgaA:
1.5		 6cb4A-3bgaA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qm1 CINNAMOYL ESTERASE

(Lactobacillus
johnsonii) 		PF12146
(Hydrolase_4) 		4 GLY A  22
LYS A  -5
GLN A  -1
ASN A  54
 NA  A 248 ( 3.8A)
CL  A 306 (-4.2A)
None
None
 1.50A 6cb4A-3qm1A:
0.3		 6cb4A-3qm1A:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus) 		PF00464
(SHMT) 		4 GLY A 324
LYS A 340
GLN A 328
ASN A 323
 None
 1.48A 6cb4A-4wxbA:
0.0		 6cb4A-4wxbA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b2w PUTATIVE
PEPTIDYL-ARGININE
DEIMINASE FAMILY
PROTEIN

(Campylobacter
jejuni) 		no annotation 4 GLY A 147
LYS A 181
GLN A 182
ASN A 144
 None
 1.02A 6cb4A-6b2wA:
0.0		 6cb4A-6b2wA:
undetectable