SIMILAR PATTERNS OF AMINO ACIDS FOR 6CB4_A_BEZA501_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1apa POKEWEED ANTIVIRAL
PROTEIN


(Phytolacca
americana)
PF00161
(RIP)
4 LEU A  76
VAL A  57
LEU A  55
ILE A   9
None
0.85A 6cb4A-1apaA:
undetectable
6cb4A-1apaA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bry BRYODIN I

(Bryonia dioica)
PF00161
(RIP)
4 LEU Y 188
VAL Y 213
LEU Y 215
ILE Y 225
None
0.92A 6cb4A-1bryY:
undetectable
6cb4A-1bryY:
21.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cau CANAVALIN

(Canavalia
ensiformis)
PF00190
(Cupin_1)
6 ASN B 284
LEU B 286
HIS B 297
ASN B 299
ILE B 348
ARG B 376
None
0.73A 6cb4A-1cauB:
13.3
6cb4A-1cauB:
99.46
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cau CANAVALIN

(Canavalia
ensiformis)
PF00190
(Cupin_1)
7 ASN B 284
LEU B 286
HIS B 297
ASN B 299
VAL B 304
LEU B 306
ILE B 348
None
0.36A 6cb4A-1cauB:
13.3
6cb4A-1cauB:
99.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cbk PROTEIN
(7,8-DIHYDRO-6-HYDRO
XYMETHYLPTERIN-PYROP
HOSPHOKINASE)


(Haemophilus
influenzae)
PF01288
(HPPK)
4 LEU A 100
VAL A 124
LEU A 128
ILE A 125
None
0.57A 6cb4A-1cbkA:
undetectable
6cb4A-1cbkA:
17.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1chd CHEB METHYLESTERASE

(Salmonella
enterica)
PF01339
(CheB_methylest)
4 LEU A 330
VAL A 278
LEU A 280
ILE A 161
None
0.82A 6cb4A-1chdA:
undetectable
6cb4A-1chdA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cis HYBRID PROTEIN
FORMED FROM
CHYMOTRYPSIN
INHIBITOR-2


(Bacillus
licheniformis;
Hordeum vulgare)
PF00280
(potato_inhibit)
4 LEU A  27
VAL A  68
LEU A  70
ILE A  48
None
0.82A 6cb4A-1cisA:
undetectable
6cb4A-1cisA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgr CANAVALIN
CANAVALIN


(Canavalia
ensiformis;
Canavalia
ensiformis)
no annotation
no annotation
8 ASN X 284
LEU X 286
HIS X 297
ASN X 299
VAL X 304
LEU X 306
ILE Y 348
ARG Y 376
PO4  X1500 ( 4.0A)
None
PO4  X1500 (-4.1A)
PO4  X1500 (-3.2A)
PO4  X1500 ( 4.8A)
None
PO4  X1500 ( 4.2A)
PO4  X1500 (-3.7A)
0.33A 6cb4A-1dgrX:
3.9
6cb4A-1dgrX:
27.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1et6 SUPERANTIGEN SMEZ-2

(Streptococcus
pyogenes)
PF01123
(Stap_Strp_toxin)
PF02876
(Stap_Strp_tox_C)
4 ASN A   6
LEU A   9
LEU A 147
ILE A 207
None
0.84A 6cb4A-1et6A:
undetectable
6cb4A-1et6A:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hkq REPLICATION PROTEIN

(Pseudomonas
savastanoi)
PF01051
(Rep_3)
4 LEU A  75
VAL A 107
LEU A 109
ILE A  48
None
0.92A 6cb4A-1hkqA:
undetectable
6cb4A-1hkqA:
16.40
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ipk BETA-CONGLYCININ,
BETA CHAIN


(Glycine max)
PF00190
(Cupin_1)
PF07883
(Cupin_2)
6 HIS A 265
ASN A 267
VAL A 272
LEU A 274
ILE A 319
ARG A 347
None
0.65A 6cb4A-1ipkA:
47.0
6cb4A-1ipkA:
54.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l1q ADENINE
PHOSPHORIBOSYLTRANSF
ERASE


(Giardia
intestinalis)
PF00156
(Pribosyltran)
4 LEU A  82
VAL A 120
LEU A 122
ILE A 150
None
0.64A 6cb4A-1l1qA:
undetectable
6cb4A-1l1qA:
16.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pp1 P40 NUCLEOPROTEIN

(Borna disease
virus)
PF06407
(BDV_P40)
5 LEU X  76
ASN X 198
VAL X 147
LEU X 143
ILE X 194
None
1.38A 6cb4A-1pp1X:
undetectable
6cb4A-1pp1X:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sml PROTEIN
(PENICILLINASE)


(Stenotrophomonas
maltophilia)
PF00753
(Lactamase_B)
4 VAL A 220
LEU A 222
ILE A 180
ARG A 173
None
0.82A 6cb4A-1smlA:
undetectable
6cb4A-1smlA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0i YLR011WP

(Saccharomyces
cerevisiae)
PF03358
(FMN_red)
4 LEU A  50
VAL A  43
LEU A  45
ILE A   6
None
0.91A 6cb4A-1t0iA:
undetectable
6cb4A-1t0iA:
18.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uik ALPHA PRIME SUBUNIT
OF BETA-CONGLYCININ


(Glycine max)
PF00190
(Cupin_1)
4 HIS A 408
ASN A 410
VAL A 415
ILE A 462
None
0.33A 6cb4A-1uikA:
46.6
6cb4A-1uikA:
53.96
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uik ALPHA PRIME SUBUNIT
OF BETA-CONGLYCININ


(Glycine max)
PF00190
(Cupin_1)
5 HIS A 408
VAL A 415
LEU A 417
ILE A 462
ARG A 490
None
0.67A 6cb4A-1uikA:
46.6
6cb4A-1uikA:
53.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6u ENDO-1,4-BETA-D-XYLA
NASE


(Streptomyces
olivaceoviridis)
PF00331
(Glyco_hydro_10)
PF00652
(Ricin_B_lectin)
4 LEU A 358
VAL A 337
LEU A 324
ILE A 420
None
0.95A 6cb4A-1v6uA:
undetectable
6cb4A-1v6uA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vbf 231AA LONG
HYPOTHETICAL
PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE


(Sulfurisphaera
tokodaii)
PF01135
(PCMT)
4 LEU A  87
ASN A 117
VAL A  95
ILE A 118
None
0.89A 6cb4A-1vbfA:
undetectable
6cb4A-1vbfA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vjo ALANINE--GLYOXYLATE
AMINOTRANSFERASE


(Nostoc sp. PCC
7120)
PF00266
(Aminotran_5)
4 ASN A  92
LEU A 242
LEU A 247
ILE A  76
None
0.90A 6cb4A-1vjoA:
undetectable
6cb4A-1vjoA:
25.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xez HEMOLYSIN

(Vibrio cholerae)
PF07968
(Leukocidin)
PF12563
(Hemolysin_N)
PF16458
(Beta-prism_lec)
4 LEU A 590
VAL A 708
LEU A 659
ILE A 616
None
0.72A 6cb4A-1xezA:
undetectable
6cb4A-1xezA:
20.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8q UBIQUITIN-LIKE 2
ACTIVATING ENZYME
E1B


(Homo sapiens)
PF00899
(ThiF)
PF14732
(UAE_UbL)
PF16195
(UBA2_C)
4 LEU B 506
VAL B 480
LEU B 490
ILE B 491
None
0.90A 6cb4A-1y8qB:
undetectable
6cb4A-1y8qB:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zy4 SERINE/THREONINE-PRO
TEIN KINASE GCN2


(Saccharomyces
cerevisiae)
PF00069
(Pkinase)
4 LEU A 663
VAL A 644
LEU A 641
ILE A 640
None
0.71A 6cb4A-1zy4A:
undetectable
6cb4A-1zy4A:
22.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a5h L-LYSINE
2,3-AMINOMUTASE


(Clostridium
subterminale)
PF04055
(Radical_SAM)
PF12544
(LAM_C)
4 LEU A 119
VAL A 194
LEU A 188
ILE A 191
None
0.70A 6cb4A-2a5hA:
undetectable
6cb4A-2a5hA:
21.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bma GLUTAMATE
DEHYDROGENASE
(NADP+)


(Plasmodium
falciparum)
PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N)
4 LEU A 277
VAL A 266
LEU A 259
ILE A 291
None
0.92A 6cb4A-2bmaA:
undetectable
6cb4A-2bmaA:
23.11
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2cav PROTEIN (CANAVALIN)

(Canavalia
ensiformis)
PF00190
(Cupin_1)
8 ASN A 284
LEU A 286
HIS A 297
ASN A 299
VAL A 304
LEU A 306
ILE A 348
ARG A 376
None
0.44A 6cb4A-2cavA:
51.3
6cb4A-2cavA:
99.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cfb GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE


(Synechococcus
elongatus)
PF00202
(Aminotran_3)
4 LEU A 257
VAL A  57
LEU A  61
ILE A  58
None
0.79A 6cb4A-2cfbA:
undetectable
6cb4A-2cfbA:
22.87
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2cv6 SEED STORAGE PROTEIN

(Vigna radiata)
PF00190
(Cupin_1)
5 HIS A 276
ASN A 278
VAL A 283
LEU A 285
ILE A 330
None
0.52A 6cb4A-2cv6A:
46.8
6cb4A-2cv6A:
50.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1c ISOCITRATE
DEHYDROGENASE


(Thermus
thermophilus)
PF00180
(Iso_dh)
4 LEU A 257
VAL A 135
LEU A 133
ILE A 240
None
0.66A 6cb4A-2d1cA:
undetectable
6cb4A-2d1cA:
22.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d1y HYPOTHETICAL PROTEIN
TT0321


(Thermus
thermophilus)
PF13561
(adh_short_C2)
4 ASN A 133
VAL A 174
LEU A 167
ILE A 131
None
0.73A 6cb4A-2d1yA:
undetectable
6cb4A-2d1yA:
20.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e6k TRANSKETOLASE

(Thermus
thermophilus)
PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
4 LEU A 156
VAL A  78
LEU A  74
ILE A  15
None
0.92A 6cb4A-2e6kA:
undetectable
6cb4A-2e6kA:
22.73
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2eaa 7S GLOBULIN-3

(Vigna angularis)
PF00190
(Cupin_1)
5 HIS A 281
ASN A 283
VAL A 288
ILE A 334
ARG A 362
ACY  A 460 (-4.0A)
ACY  A 460 (-3.1A)
None
ACY  A 460 (-4.7A)
ACY  A 460 (-4.5A)
0.36A 6cb4A-2eaaA:
47.5
6cb4A-2eaaA:
51.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hzf GLUTAREDOXIN-1

(Ectromelia
virus)
PF00462
(Glutaredoxin)
4 LEU A  33
VAL A 104
LEU A  99
ILE A 102
None
0.67A 6cb4A-2hzfA:
undetectable
6cb4A-2hzfA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2km8 MRNA
3'-END-PROCESSING
PROTEIN RNA15


(Saccharomyces
cerevisiae)
PF00076
(RRM_1)
4 LEU B  92
VAL B  28
LEU B  30
ILE B  72
None
0.88A 6cb4A-2km8B:
undetectable
6cb4A-2km8B:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1b AMINOTRANSFERASE,
CLASS I


(Staphylococcus
aureus)
PF00155
(Aminotran_1_2)
4 LEU A 308
VAL A 319
LEU A 321
ILE A 360
None
0.58A 6cb4A-2o1bA:
undetectable
6cb4A-2o1bA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o3j UDP-GLUCOSE
6-DEHYDROGENASE


(Caenorhabditis
elegans)
PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N)
4 ASN A 166
LEU A 164
VAL A 185
ILE A 215
None
0.94A 6cb4A-2o3jA:
undetectable
6cb4A-2o3jA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2okb DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE


(Vaccinia virus)
PF00692
(dUTPase)
4 LEU A  72
VAL A  94
LEU A  96
ILE A  50
None
0.81A 6cb4A-2okbA:
undetectable
6cb4A-2okbA:
13.57
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2phl PHASEOLIN

(Phaseolus
vulgaris)
PF00190
(Cupin_1)
4 HIS A 255
VAL A 262
LEU A 264
ILE A 302
None
0.36A 6cb4A-2phlA:
41.1
6cb4A-2phlA:
44.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2poz PUTATIVE DEHYDRATASE

(Mesorhizobium
japonicum)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 LEU A  55
VAL A   8
LEU A  60
ILE A  25
None
0.91A 6cb4A-2pozA:
undetectable
6cb4A-2pozA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wbp L-ARGININE
BETA-HYDROXYLASE


(Streptomyces
vinaceus)
PF02668
(TauD)
4 ASN A 311
VAL A 181
LEU A 183
ILE A 309
None
0.91A 6cb4A-2wbpA:
3.6
6cb4A-2wbpA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xec PUTATIVE MALEATE
ISOMERASE


(Nocardia
farcinica)
no annotation 4 LEU A 226
VAL A  71
ILE A   6
ARG A   4
None
0.91A 6cb4A-2xecA:
undetectable
6cb4A-2xecA:
20.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ykq LINE-1 ORF1P

(Homo sapiens)
PF02994
(Transposase_22)
PF17489
(Tnp_22_trimer)
PF17490
(Tnp_22_dsRBD)
4 LEU A 178
VAL A 163
LEU A 160
ILE A 247
None
0.83A 6cb4A-2ykqA:
undetectable
6cb4A-2ykqA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bt3 GLYOXALASE-RELATED
ENZYME, ARAC TYPE


(Lachnoclostridium
phytofermentans)
no annotation 4 LEU A 258
VAL A 227
LEU A 162
ILE A 161
None
0.88A 6cb4A-3bt3A:
undetectable
6cb4A-3bt3A:
14.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dh9 THIOREDOXIN
REDUCTASE 1


(Drosophila
melanogaster)
PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2)
4 LEU A 452
VAL A 375
LEU A 430
ILE A 441
None
0.79A 6cb4A-3dh9A:
undetectable
6cb4A-3dh9A:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euj CHROMOSOME PARTITION
PROTEIN MUKB, LINKER


([Haemophilus]
ducreyi)
PF04310
(MukB)
PF13558
(SbcCD_C)
4 LEU A1407
VAL A1301
LEU A1290
ILE A1293
None
0.89A 6cb4A-3eujA:
undetectable
6cb4A-3eujA:
24.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hi8 PROLIFERATING CELL
NUCLEAR ANTIGEN PCNA


(Haloferax
volcanii)
PF00705
(PCNA_N)
PF02747
(PCNA_C)
4 ASN A 204
LEU A 200
VAL A 213
LEU A 225
None
0.88A 6cb4A-3hi8A:
undetectable
6cb4A-3hi8A:
21.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihk THIAMIN
PYROPHOSPHOKINASE


(Streptococcus
mutans)
PF04263
(TPK_catalytic)
PF04265
(TPK_B1_binding)
4 ASN A  35
LEU A  32
LEU A  12
ARG A  17
None
0.77A 6cb4A-3ihkA:
undetectable
6cb4A-3ihkA:
19.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l1f ALPHA-CRYSTALLIN A
CHAIN


(Bos taurus)
PF00011
(HSP20)
4 LEU A 133
VAL A  87
LEU A  85
ILE A  96
None
0.92A 6cb4A-3l1fA:
undetectable
6cb4A-3l1fA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mti RRNA METHYLASE

(Streptococcus
thermophilus)
PF06962
(rRNA_methylase)
4 LEU A 153
VAL A 176
LEU A 178
ILE A 130
None
0.76A 6cb4A-3mtiA:
undetectable
6cb4A-3mtiA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n3e ALPHA A CRYSTALLIN

(Danio rerio)
PF00011
(HSP20)
4 LEU A 134
VAL A  88
LEU A  86
ILE A  97
None
0.90A 6cb4A-3n3eA:
undetectable
6cb4A-3n3eA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ney 55 KDA ERYTHROCYTE
MEMBRANE PROTEIN


(Homo sapiens)
PF00625
(Guanylate_kin)
4 LEU A 302
ASN A 436
LEU A 287
ILE A 400
None
0.80A 6cb4A-3neyA:
undetectable
6cb4A-3neyA:
17.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o75 FRUCTOSE TRANSPORT
SYSTEM REPRESSOR
FRUR


(Pseudomonas
putida)
PF00532
(Peripla_BP_1)
4 LEU A 137
VAL A 123
LEU A 121
ILE A  67
None
0.85A 6cb4A-3o75A:
undetectable
6cb4A-3o75A:
21.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oc6 6-PHOSPHOGLUCONOLACT
ONASE


(Mycolicibacterium
smegmatis)
PF01182
(Glucosamine_iso)
4 LEU A  51
VAL A  24
LEU A  23
ILE A  27
None
0.91A 6cb4A-3oc6A:
undetectable
6cb4A-3oc6A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q9q HEAT SHOCK PROTEIN
BETA-1


(Homo sapiens)
PF00011
(HSP20)
4 LEU A 157
VAL A 111
LEU A 109
ILE A 120
None
0.95A 6cb4A-3q9qA:
undetectable
6cb4A-3q9qA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rit DIPEPTIDE EPIMERASE

(Methylococcus
capsulatus)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 LEU A 181
VAL A 161
LEU A 159
ILE A 136
None
0.95A 6cb4A-3ritA:
undetectable
6cb4A-3ritA:
22.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3s7i ALLERGEN ARA H 1,
CLONE P41B


(Arachis
hypogaea)
PF00190
(Cupin_1)
4 HIS A 447
ASN A 449
VAL A 454
ARG A 540
CL  A   1 (-4.3A)
CL  A   1 ( 4.4A)
None
CL  A   1 (-4.5A)
0.37A 6cb4A-3s7iA:
46.2
6cb4A-3s7iA:
39.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3s7i ALLERGEN ARA H 1,
CLONE P41B


(Arachis
hypogaea)
PF00190
(Cupin_1)
4 LEU A 528
HIS A 447
ASN A 449
VAL A 454
None
CL  A   1 (-4.3A)
CL  A   1 ( 4.4A)
None
0.70A 6cb4A-3s7iA:
46.2
6cb4A-3s7iA:
39.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sql GLYCOSYL HYDROLASE
FAMILY 3


(Synechococcus
sp. PCC 7002)
PF00933
(Glyco_hydro_3)
4 LEU A 188
VAL A 275
LEU A 273
ILE A 304
None
0.85A 6cb4A-3sqlA:
undetectable
6cb4A-3sqlA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w1j L-SERYL-TRNA(SEC)
SELENIUM TRANSFERASE


(Aquifex
aeolicus)
PF03841
(SelA)
4 LEU A 385
VAL A 341
LEU A 345
ILE A 342
None
LLP  A 285 ( 4.9A)
None
None
0.90A 6cb4A-3w1jA:
undetectable
6cb4A-3w1jA:
23.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zid TUBULIN/FTSZ, GTPASE

(Methanothrix
thermoacetophila)
PF00091
(Tubulin)
4 LEU A 128
VAL A   9
LEU A   7
ILE A  48
None
0.78A 6cb4A-3zidA:
undetectable
6cb4A-3zidA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4asc KELCH REPEAT AND BTB
DOMAIN-CONTAINING
PROTEIN 5


(Homo sapiens)
PF01344
(Kelch_1)
4 LEU A 555
ASN A 359
VAL A 355
ARG A 612
None
0.95A 6cb4A-4ascA:
undetectable
6cb4A-4ascA:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cs6 AMINOGLYCOSIDE
ADENYLTRANSFERASE


(Salmonella
enterica)
PF01909
(NTP_transf_2)
PF13427
(DUF4111)
4 LEU A  86
VAL A  52
LEU A  50
ILE A  31
None
0.93A 6cb4A-4cs6A:
undetectable
6cb4A-4cs6A:
20.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dfe 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3


(Paraburkholderia
xenovorans)
PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III)
4 VAL A 300
LEU A 296
ILE A 305
ARG A 307
None
0.88A 6cb4A-4dfeA:
undetectable
6cb4A-4dfeA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eec STAL

(Streptomyces
toyocaensis)
PF00685
(Sulfotransfer_1)
4 LEU A 166
VAL A  86
LEU A  88
ILE A   7
None
0.79A 6cb4A-4eecA:
undetectable
6cb4A-4eecA:
20.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewc PUTATIVE
NUCLEOPROTEIN


(Salmon isavirus)
no annotation 4 LEU A 151
ASN A 204
VAL A 217
LEU A 222
None
0.72A 6cb4A-4ewcA:
undetectable
6cb4A-4ewcA:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gnk 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3


(Homo sapiens)
PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like)
4 ASN B 830
LEU B 811
ILE B 810
ARG B 826
None
0.91A 6cb4A-4gnkB:
undetectable
6cb4A-4gnkB:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kdi UBIQUITIN
THIOESTERASE OTU1


(Saccharomyces
cerevisiae)
no annotation 4 LEU C  16
VAL C   5
LEU C   3
ILE C  70
None
0.95A 6cb4A-4kdiC:
undetectable
6cb4A-4kdiC:
11.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m5p NADPH DEHYDROGENASE

(Scheffersomyces
stipitis)
PF00724
(Oxidored_FMN)
4 LEU A 112
VAL A 232
LEU A 228
ILE A 231
None
0.90A 6cb4A-4m5pA:
undetectable
6cb4A-4m5pA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mjh HEAT SHOCK PROTEIN
BETA-1


(Homo sapiens)
PF00011
(HSP20)
4 LEU A 157
VAL A 111
LEU A 109
ILE A 120
None
0.90A 6cb4A-4mjhA:
undetectable
6cb4A-4mjhA:
12.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n81 INOSITOL
MONOPHOSPHATASE


(Zymomonas
mobilis)
PF00459
(Inositol_P)
4 LEU A 150
VAL A 202
LEU A 200
ILE A 242
None
0.78A 6cb4A-4n81A:
undetectable
6cb4A-4n81A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbw SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR


(Plesiocystis
pacifica)
PF13561
(adh_short_C2)
4 ASN A 154
VAL A 195
LEU A 188
ILE A 152
None
0.84A 6cb4A-4nbwA:
undetectable
6cb4A-4nbwA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oah MITOCHONDRIAL
DYNAMIC PROTEIN
MID51


(Mus musculus)
PF03281
(Mab-21)
4 LEU A 204
VAL A 300
LEU A 298
ILE A 287
None
0.78A 6cb4A-4oahA:
undetectable
6cb4A-4oahA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ooq DEOXYURIDINE
5'-TRIPHOSPHATE
NUCLEOTIDOHYDROLASE


(Arabidopsis
thaliana)
PF00692
(dUTPase)
4 LEU A  91
VAL A 114
LEU A 116
ILE A  69
None
0.81A 6cb4A-4ooqA:
undetectable
6cb4A-4ooqA:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4up7 LYSINE--TRNA LIGASE

(Entamoeba
histolytica)
PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
4 VAL A 164
LEU A 160
ILE A 163
ARG A 106
None
0.83A 6cb4A-4up7A:
undetectable
6cb4A-4up7A:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xs5 SULFATE
TRANSPORTER/ANTISIGM
A-FACTOR ANTAGONIST
STAS


(Dyadobacter
fermentans)
PF01740
(STAS)
4 LEU A  92
VAL A  99
LEU A  97
ILE A  78
None
0.85A 6cb4A-4xs5A:
undetectable
6cb4A-4xs5A:
15.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yeb FIBRONECTIN LEUCINE
RICH TRANSMEMBRANE
PROTEIN 3


(Mus musculus)
PF13855
(LRR_8)
4 LEU B  90
VAL B 106
LEU B 109
ILE B 127
None
0.83A 6cb4A-4yebB:
undetectable
6cb4A-4yebB:
23.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5e1r 7S VICILIN

(Carya
illinoinensis)
PF00190
(Cupin_1)
6 ASN A 617
HIS A 630
ASN A 632
VAL A 637
ILE A 694
ARG A 724
MPD  A 802 (-3.5A)
MPD  A 802 (-4.1A)
MPD  A 802 (-3.4A)
MPD  A 802 (-4.9A)
None
MPD  A 802 (-4.5A)
0.26A 6cb4A-5e1rA:
43.1
6cb4A-5e1rA:
33.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq2 SUMO-ACTIVATING
ENZYME SUBUNIT 2


(Homo sapiens)
PF14732
(UAE_UbL)
4 LEU B 506
VAL B 480
LEU B 490
ILE B 491
MLZ  B 505 ( 4.2A)
None
None
None
0.84A 6cb4A-5fq2B:
undetectable
6cb4A-5fq2B:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fq6 SUSC/RAGA FAMILY
TONB-LINKED OUTER
MEMBRANE PROTEIN


(Bacteroides
thetaiotaomicron)
PF00593
(TonB_dep_Rec)
PF07715
(Plug)
4 ASN B  98
LEU B 960
ASN B 699
ILE B 697
None
0.81A 6cb4A-5fq6B:
undetectable
6cb4A-5fq6B:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gtm INTERFERON-INDUCED
GTP-BINDING PROTEIN
MX1


(Homo sapiens)
PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED)
4 LEU A 176
VAL A 216
LEU A 214
ILE A 245
None
0.74A 6cb4A-5gtmA:
undetectable
6cb4A-5gtmA:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h1c DNA REPAIR PROTEIN
RAD51 HOMOLOG 1


(Homo sapiens)
PF08423
(Rad51)
PF14520
(HHH_5)
4 LEU A 255
VAL A 221
LEU A 219
ILE A 160
None
0.92A 6cb4A-5h1cA:
undetectable
6cb4A-5h1cA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h5t FLAGELLAR
HOOK-ASSOCIATED
PROTEIN 2


(Salmonella
enterica)
PF07195
(FliD_C)
PF07196
(Flagellin_IN)
4 LEU A 121
VAL A 197
LEU A 207
ILE A 131
None
0.87A 6cb4A-5h5tA:
undetectable
6cb4A-5h5tA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h9v RIBONUCLEASE ZC3H12A

(Mus musculus)
PF11977
(RNase_Zc3h12a)
4 LEU A 288
HIS A 172
VAL A 239
LEU A 265
None
0.85A 6cb4A-5h9vA:
undetectable
6cb4A-5h9vA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hdt SISTER CHROMATID
COHESION PROTEIN
PDS5 HOMOLOG B


(Homo sapiens)
no annotation 4 LEU A 553
VAL A 529
LEU A 509
ILE A 532
None
0.93A 6cb4A-5hdtA:
undetectable
6cb4A-5hdtA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5id4 DSBA-LIKE PROTEIN

(Proteus
mirabilis)
PF13462
(Thioredoxin_4)
4 LEU A  94
VAL A 215
LEU A 211
ILE A 214
None
0.92A 6cb4A-5id4A:
undetectable
6cb4A-5id4A:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l5n PLEXIN-A4

(Mus musculus)
PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG)
4 ASN A 409
LEU A 406
LEU A 397
ILE A 399
ASN  A 409 ( 0.6A)
LEU  A 406 ( 0.5A)
LEU  A 397 ( 0.5A)
ILE  A 399 ( 0.7A)
0.92A 6cb4A-5l5nA:
undetectable
6cb4A-5l5nA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o3w PEPTIDE CYCLASE 1

(Gypsophila
vaccaria)
no annotation 4 ASN A 263
VAL A 265
LEU A 292
ILE A 293
None
0.94A 6cb4A-5o3wA:
undetectable
6cb4A-5o3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o96 RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E


(Legionella
pneumophila)
no annotation 4 LEU A 217
VAL A 191
LEU A 193
ILE A  82
None
0.79A 6cb4A-5o96A:
undetectable
6cb4A-5o96A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u6u CYTOCHROME P450

(Rhodopseudomonas
palustris)
no annotation 4 LEU A 375
VAL A 404
LEU A 406
ILE A 145
None
0.95A 6cb4A-5u6uA:
undetectable
6cb4A-5u6uA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vat PENICILLIN-BINDING
PROTEIN ACTIVATOR
LPOA


(Haemophilus
influenzae)
PF04348
(LppC)
4 ASN A 429
VAL A 455
LEU A 451
ILE A 454
None
0.94A 6cb4A-5vatA:
undetectable
6cb4A-5vatA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vgr ATLASTIN-3

(Homo sapiens)
PF02263
(GBP)
PF02841
(GBP_C)
4 ASN A 173
VAL A  65
ILE A 171
ARG A 213
None
None
None
GDP  A 501 (-3.7A)
0.79A 6cb4A-5vgrA:
undetectable
6cb4A-5vgrA:
20.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vh6 ELONGATION FACTOR G

(Bacillus
subtilis)
PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
4 LEU A 388
VAL A 368
LEU A 334
ILE A 354
None
0.84A 6cb4A-5vh6A:
undetectable
6cb4A-5vh6A:
21.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vps SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR


(Burkholderia
ambifaria)
PF13561
(adh_short_C2)
4 ASN A 137
VAL A 164
LEU A 167
ILE A 178
None
0.90A 6cb4A-5vpsA:
undetectable
6cb4A-5vpsA:
22.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wm4 SALICYLATE-AMP
LIGASE


(Streptomyces
gandocaensis)
no annotation 4 LEU A 324
VAL A 294
LEU A 321
ILE A 289
None
0.90A 6cb4A-5wm4A:
undetectable
6cb4A-5wm4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi 40S RIBOSOMAL
PROTEIN S7, PUTATIVE
40S RIBOSOMAL
PROTEIN S13,
PUTATIVE
RIBOSOMAL PROTEIN
S15A


(Trichomonas
vaginalis;
Trichomonas
vaginalis;
Trichomonas
vaginalis)
PF01251
(Ribosomal_S7e)
PF00312
(Ribosomal_S15)
PF08069
(Ribosomal_S13_N)
PF00410
(Ribosomal_S8)
4 HIS W  56
LEU H 106
ILE H 115
ARG N  20
None
0.94A 6cb4A-5xyiW:
undetectable
6cb4A-5xyiW:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ao8 ARGININE--TRNA
LIGASE


(Neisseria
gonorrhoeae)
PF00750
(tRNA-synt_1d)
PF03485
(Arg_tRNA_synt_N)
PF05746
(DALR_1)
4 LEU A 146
VAL A 335
LEU A 333
ILE A 366
None
0.91A 6cb4A-6ao8A:
undetectable
6cb4A-6ao8A:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c3p ATP-BINDING CASSETTE
SUB-FAMILY C MEMBER
8


(Homo sapiens)
no annotation 4 LEU E 829
LEU E 814
ILE E 811
ARG E 836
None
0.81A 6cb4A-6c3pE:
undetectable
6cb4A-6c3pE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MBH13 NADH
DEHYDROGENASE
SUBUNIT
NADH-PLASTOQUINONE
OXIDOREDUCTASE
SUBUNIT


(Pyrococcus
furiosus;
Pyrococcus
furiosus)
no annotation
no annotation
4 LEU M  31
VAL N  10
LEU N  14
ILE N  11
None
0.75A 6cb4A-6cfwM:
undetectable
6cb4A-6cfwM:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dch SCOE PROTEIN

(Streptomyces
coeruleorubidus)
no annotation 4 LEU A  86
VAL A 313
LEU A  90
ILE A 144
None
0.95A 6cb4A-6dchA:
2.9
6cb4A-6dchA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fg9 -

(-)
no annotation 4 LEU A1017
VAL A1062
LEU A1045
ILE A1050
None
0.87A 6cb4A-6fg9A:
undetectable
6cb4A-6fg9A:
undetectable