SIMILAR PATTERNS OF AMINO ACIDS FOR 6CA1_B_MIGB701_1
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nnh | ASPARAGINYL-TRNASYNTHETASE-RELATEDPEPTIDE (Pyrococcusfuriosus) |
PF00152(tRNA-synt_2) | 5 | ASP A 173ILE A 208ILE A 186ARG A 191ASP A 52 | None | 1.20A | 6ca1B-1nnhA:undetectable | 6ca1B-1nnhA:14.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1nnh | ASPARAGINYL-TRNASYNTHETASE-RELATEDPEPTIDE (Pyrococcusfuriosus) |
PF00152(tRNA-synt_2) | 5 | ASP A 173ILE A 208ILE A 186ASP A 206ASP A 52 | None | 1.33A | 6ca1B-1nnhA:undetectable | 6ca1B-1nnhA:14.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g3n | ALPHA-GLUCOSIDASE (Sulfolobussolfataricus) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2) | 10 | ASP A 212ILE A 213ILE A 249ASP A 320MET A 321ARG A 400TRP A 413ASP A 416PHE A 449HIS A 480 | NoneNoneNoneNoneBOG A2000 ( 4.0A)BOG A2000 (-3.1A)NoneBOG A2000 (-3.0A)NoneNone | 0.34A | 6ca1B-2g3nA:41.8 | 6ca1B-2g3nA:9.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g3n | ALPHA-GLUCOSIDASE (Sulfolobussolfataricus) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2) | 7 | ASP A 212ILE A 213ILE A 249TRP A 318TRP A 413PHE A 449HIS A 480 | None | 0.84A | 6ca1B-2g3nA:41.8 | 6ca1B-2g3nA:9.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2g3n | ALPHA-GLUCOSIDASE (Sulfolobussolfataricus) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2) | 7 | ASP A 212ILE A 249MET A 321ARG A 400ASP A 416PHE A 449HIS A 480 | NoneNoneBOG A2000 ( 4.0A)BOG A2000 (-3.1A)BOG A2000 (-3.0A)NoneNone | 1.39A | 6ca1B-2g3nA:41.8 | 6ca1B-2g3nA:9.06 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2x2i | ALPHA-1,4-GLUCANLYASE ISOZYME 1 (Gracilariopsislemaneiformis) |
PF01055(Glyco_hydro_31) | 8 | ASP A 412ASP A 553MET A 554ARG A 649TRP A 662ASP A 665PHE A 698HIS A 731 | QPS A1050 (-3.2A)QPS A1050 (-3.1A)QPS A1050 (-3.1A)QPS A1050 (-3.2A)QPS A1050 (-4.6A)QPS A1050 (-2.7A)QPS A1050 (-4.3A)QPS A1050 (-4.3A) | 0.38A | 6ca1B-2x2iA:36.3 | 6ca1B-2x2iA:6.45 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xvg | ALPHA XYLOSIDASE (Cellvibriojaponicus) |
PF01055(Glyco_hydro_31)PF16338(DUF4968)PF17137(DUF5110) | 7 | ASP A 470ASP A 582ARG A 642TRP A 656ASP A 659PHE A 692HIS A 740 | None | 0.36A | 6ca1B-2xvgA:36.9 | 6ca1B-2xvgA:5.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xvg | ALPHA XYLOSIDASE (Cellvibriojaponicus) |
PF01055(Glyco_hydro_31)PF16338(DUF4968)PF17137(DUF5110) | 7 | TRP A 471ASP A 470ARG A 642TRP A 656ASP A 659PHE A 692HIS A 740 | EDO A1997 ( 4.5A)NoneNoneNoneNoneNoneNone | 0.70A | 6ca1B-2xvgA:36.9 | 6ca1B-2xvgA:5.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2xvg | ALPHA XYLOSIDASE (Cellvibriojaponicus) |
PF01055(Glyco_hydro_31)PF16338(DUF4968)PF17137(DUF5110) | 6 | TRP A 471ASP A 470TRP A 580TRP A 656PHE A 692HIS A 740 | EDO A1997 ( 4.5A)NoneNoneNoneNoneNone | 1.11A | 6ca1B-2xvgA:36.9 | 6ca1B-2xvgA:5.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ctt | MALTASE-GLUCOAMYLASE (Homo sapiens) |
PF00088(Trefoil)PF01055(Glyco_hydro_31)PF16863(NtCtMGAM_N) | 10 | ASP A 327ILE A 328ILE A 364ASP A 443MET A 444ARG A 526TRP A 539ASP A 542PHE A 575HIS A 600 | 3CU A1001 (-2.7A)3CU A1001 ( 3.9A)3CU A1001 (-4.5A)3CU A1001 (-2.7A)3CU A1001 ( 3.9A)3CU A1001 ( 3.5A)3CU A1001 (-4.6A)3CU A1001 ( 2.5A)3CU A1001 (-4.5A)3CU A1001 (-3.9A) | 0.40A | 6ca1B-3cttA:39.4 | 6ca1B-3cttA:6.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ctt | MALTASE-GLUCOAMYLASE (Homo sapiens) |
PF00088(Trefoil)PF01055(Glyco_hydro_31)PF16863(NtCtMGAM_N) | 6 | ASP A 327ILE A 328ILE A 364TRP A 441PHE A 575HIS A 600 | 3CU A1001 (-2.7A)3CU A1001 ( 3.9A)3CU A1001 (-4.5A)3CU A1001 (-4.9A)3CU A1001 (-4.5A)3CU A1001 (-3.9A) | 0.79A | 6ca1B-3cttA:39.4 | 6ca1B-3cttA:6.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ctt | MALTASE-GLUCOAMYLASE (Homo sapiens) |
PF00088(Trefoil)PF01055(Glyco_hydro_31)PF16863(NtCtMGAM_N) | 7 | ASP A 327ILE A 364MET A 444ARG A 526ASP A 542PHE A 575HIS A 600 | 3CU A1001 (-2.7A)3CU A1001 (-4.5A)3CU A1001 ( 3.9A)3CU A1001 ( 3.5A)3CU A1001 ( 2.5A)3CU A1001 (-4.5A)3CU A1001 (-3.9A) | 1.44A | 6ca1B-3cttA:39.4 | 6ca1B-3cttA:6.67 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3i4s | HISTIDINE TRIADPROTEIN (Bradyrhizobiumjaponicum) |
PF01230(HIT) | 5 | TRP A 70ILE A 63ASP A 48ARG A 44HIS A 127 | None | 1.44A | 6ca1B-3i4sA:undetectable | 6ca1B-3i4sA:16.89 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3j9d | OUTER CAPSID PROTEINVP2 (Bluetonguevirus) |
PF00898(Orbi_VP2) | 5 | ILE A 176ILE A 670ASP A 669ARG A 695ASP A 111 | None | 1.31A | 6ca1B-3j9dA:undetectable | 6ca1B-3j9dA:6.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lm3 | UNCHARACTERIZEDPROTEIN (Parabacteroidesdistasonis) |
PF12979(DUF3863)PF12980(DUF3864) | 5 | ASP A 452ILE A 443ASP A 414ARG A 396ASP A 213 | None | 1.36A | 6ca1B-3lm3A:3.9 | 6ca1B-3lm3A:10.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lpp | SUCRASE-ISOMALTASE (Homo sapiens) |
PF00088(Trefoil)PF01055(Glyco_hydro_31)PF16863(NtCtMGAM_N) | 7 | ASP A 355ILE A 392MET A 473ARG A 555ASP A 571PHE A 604HIS A 629 | TRS A6001 (-2.9A)NoneTRS A6001 ( 3.7A)TRS A6001 ( 4.6A)TRS A6001 ( 3.7A)TRS A6001 (-4.4A)TRS A6001 (-4.2A) | 1.42A | 6ca1B-3lppA:36.4 | 6ca1B-3lppA:9.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lpp | SUCRASE-ISOMALTASE (Homo sapiens) |
PF00088(Trefoil)PF01055(Glyco_hydro_31)PF16863(NtCtMGAM_N) | 11 | TRP A 327ASP A 355ILE A 356ILE A 392ASP A 472MET A 473ARG A 555TRP A 568ASP A 571PHE A 604HIS A 629 | TRS A6001 ( 3.8A)TRS A6001 (-2.9A)TRS A6001 ( 4.0A)NoneTRS A6001 (-3.2A)TRS A6001 ( 3.7A)TRS A6001 ( 4.6A)NoneTRS A6001 ( 3.7A)TRS A6001 (-4.4A)TRS A6001 (-4.2A) | 0.39A | 6ca1B-3lppA:36.4 | 6ca1B-3lppA:9.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lpp | SUCRASE-ISOMALTASE (Homo sapiens) |
PF00088(Trefoil)PF01055(Glyco_hydro_31)PF16863(NtCtMGAM_N) | 8 | TRP A 327ASP A 355ILE A 356ILE A 392TRP A 470TRP A 568PHE A 604HIS A 629 | TRS A6001 ( 3.8A)TRS A6001 (-2.9A)TRS A6001 ( 4.0A)NoneNoneNoneTRS A6001 (-4.4A)TRS A6001 (-4.2A) | 0.83A | 6ca1B-3lppA:36.4 | 6ca1B-3lppA:9.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p8t | ASNS-LIKEASPARAGINYL-TRNASYNTHETASE RELATEDPROTEIN (Pyrococcusabyssi) |
PF00152(tRNA-synt_2) | 5 | ASP A 173ILE A 208ILE A 186ARG A 191ASP A 52 | None | 1.30A | 6ca1B-3p8tA:undetectable | 6ca1B-3p8tA:15.12 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p8t | ASNS-LIKEASPARAGINYL-TRNASYNTHETASE RELATEDPROTEIN (Pyrococcusabyssi) |
PF00152(tRNA-synt_2) | 5 | ASP A 173ILE A 208ILE A 186ASP A 206ASP A 52 | None | 1.44A | 6ca1B-3p8tA:undetectable | 6ca1B-3p8tA:15.12 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3poc | ALPHA-GLUCOSIDASE (Blautia obeum) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2) | 11 | TRP A 169ASP A 197ILE A 198ILE A 234TRP A 305MET A 308ARG A 404TRP A 417ASP A 420PHE A 453HIS A 478 | ACR A 664 (-3.7A)ACR A 664 (-2.9A)ACR A 664 (-3.5A)NoneNoneACR A 664 ( 3.8A)ACR A 664 (-4.0A)ACR A 664 (-4.6A)ACR A 664 (-2.8A)ACR A 664 (-4.4A)ACR A 664 (-4.2A) | 0.20A | 6ca1B-3pocA:71.3 | 6ca1B-3pocA:100.00 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3top | MALTASE-GLUCOAMYLASE, INTESTINAL (Homo sapiens) |
PF00088(Trefoil)PF01055(Glyco_hydro_31)PF16863(NtCtMGAM_N) | 10 | ASP A1279ILE A1280ILE A1315ASP A1420MET A1421ARG A1510TRP A1523ASP A1526PHE A1559HIS A1584 | ACR A 1 (-3.2A)ACR A 1 (-4.1A)NoneACR A 1 (-3.6A)ACR A 1 (-3.5A)ACR A 1 (-2.9A)ACR A 1 (-4.5A)ACR A 1 (-2.8A)ACR A 1 (-4.3A)ACR A 1 (-3.9A) | 0.44A | 6ca1B-3topA:36.9 | 6ca1B-3topA:6.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3top | MALTASE-GLUCOAMYLASE, INTESTINAL (Homo sapiens) |
PF00088(Trefoil)PF01055(Glyco_hydro_31)PF16863(NtCtMGAM_N) | 6 | ASP A1279ILE A1280ILE A1315TRP A1418PHE A1559HIS A1584 | ACR A 1 (-3.2A)ACR A 1 (-4.1A)NoneNoneACR A 1 (-4.3A)ACR A 1 (-3.9A) | 0.87A | 6ca1B-3topA:36.9 | 6ca1B-3topA:6.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wel | ALPHA-GLUCOSIDASE (Beta vulgaris) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2)PF16863(NtCtMGAM_N) | 6 | ASP A 357ILE A 396MET A 470ARG A 552ASP A 568PHE A 601 | ACR A1001 (-3.0A)ACR A1001 (-4.9A)ACR A1001 (-3.3A)ACR A1001 (-3.0A)ACR A1001 (-2.7A)ACR A1001 (-4.3A) | 1.48A | 6ca1B-3welA:37.7 | 6ca1B-3welA:6.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wel | ALPHA-GLUCOSIDASE (Beta vulgaris) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2)PF16863(NtCtMGAM_N) | 11 | TRP A 329ASP A 357ILE A 358ILE A 396ASP A 469MET A 470ARG A 552TRP A 565ASP A 568PHE A 601HIS A 626 | ACR A1001 (-4.1A)ACR A1001 (-3.0A)ACR A1001 (-3.6A)ACR A1001 (-4.9A)ACR A1001 (-3.2A)ACR A1001 (-3.3A)ACR A1001 (-3.0A)ACR A1001 (-4.8A)ACR A1001 (-2.7A)ACR A1001 (-4.3A)ACR A1001 (-4.1A) | 0.41A | 6ca1B-3welA:37.7 | 6ca1B-3welA:6.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3wel | ALPHA-GLUCOSIDASE (Beta vulgaris) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2)PF16863(NtCtMGAM_N) | 8 | TRP A 329ASP A 357ILE A 358ILE A 396TRP A 467TRP A 565PHE A 601HIS A 626 | ACR A1001 (-4.1A)ACR A1001 (-3.0A)ACR A1001 (-3.6A)ACR A1001 (-4.9A)NoneACR A1001 (-4.8A)ACR A1001 (-4.3A)ACR A1001 (-4.1A) | 0.84A | 6ca1B-3welA:37.7 | 6ca1B-3welA:6.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b9y | ALPHA-GLUCOSIDASE,PUTATIVE, ADG31B (Cellvibriojaponicus) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2)PF16338(DUF4968)PF17137(DUF5110) | 6 | ASP A 299ILE A 341ARG A 463ASP A 480PHE A 513HIS A 540 | None | 1.34A | 6ca1B-4b9yA:34.9 | 6ca1B-4b9yA:7.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b9y | ALPHA-GLUCOSIDASE,PUTATIVE, ADG31B (Cellvibriojaponicus) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2)PF16338(DUF4968)PF17137(DUF5110) | 8 | ASP A 299ILE A 341ASP A 412ARG A 463TRP A 477ASP A 480PHE A 513HIS A 540 | None | 0.42A | 6ca1B-4b9yA:34.9 | 6ca1B-4b9yA:7.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4b9y | ALPHA-GLUCOSIDASE,PUTATIVE, ADG31B (Cellvibriojaponicus) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2)PF16338(DUF4968)PF17137(DUF5110) | 5 | ASP A 299ILE A 341TRP A 410PHE A 513HIS A 540 | None | 0.86A | 6ca1B-4b9yA:34.9 | 6ca1B-4b9yA:7.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5aw4 | NA, K-ATPASE ALPHASUBUNIT (Squalusacanthias) |
PF00122(E1-E2_ATPase)PF00689(Cation_ATPase_C)PF00690(Cation_ATPase_N)PF13246(Cation_ATPase) | 5 | ASP A 933ILE A 998ILE A 857ASP A1002ARG A1006 | None | 1.39A | 6ca1B-5aw4A:undetectable | 6ca1B-5aw4A:5.62 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d0f | UNCHARACTERIZEDPROTEIN ([Candida]glabrata) |
PF06202(GDE_C)PF14699(hGDE_N)PF14701(hDGE_amylase)PF14702(hGDE_central) | 5 | TRP A1075ASP A1078TRP A1510TRP A1239ASP A1241 | CEX A2002 (-4.9A)NoneNoneNoneCEX A2002 (-4.5A) | 1.05A | 6ca1B-5d0fA:6.6 | 6ca1B-5d0fA:4.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dkx | ALPHAGLUCOSIDASE-LIKEPROTEIN (Chaetomiumthermophilum) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2)PF17137(DUF5110) | 8 | ASP A 443ILE A 480ASP A 556MET A 557ARG A 617ASP A 633PHE A 666HIS A 691 | TRS A1001 (-2.9A)NoneTRS A1001 (-3.2A)TRS A1001 (-3.5A)TRS A1001 (-4.0A)TRS A1001 (-2.8A)TRS A1001 (-4.5A)TRS A1001 (-4.0A) | 1.31A | 6ca1B-5dkxA:33.0 | 6ca1B-5dkxA:7.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dkx | ALPHAGLUCOSIDASE-LIKEPROTEIN (Chaetomiumthermophilum) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2)PF17137(DUF5110) | 11 | TRP A 415ASP A 443ILE A 444ILE A 480ASP A 556MET A 557ARG A 617TRP A 630ASP A 633PHE A 666HIS A 691 | NoneTRS A1001 (-2.9A)TRS A1001 ( 4.1A)NoneTRS A1001 (-3.2A)TRS A1001 (-3.5A)TRS A1001 (-4.0A)NoneTRS A1001 (-2.8A)TRS A1001 (-4.5A)TRS A1001 (-4.0A) | 0.46A | 6ca1B-5dkxA:33.0 | 6ca1B-5dkxA:7.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dkx | ALPHAGLUCOSIDASE-LIKEPROTEIN (Chaetomiumthermophilum) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2)PF17137(DUF5110) | 8 | TRP A 415ASP A 443ILE A 444ILE A 480TRP A 554TRP A 630PHE A 666HIS A 691 | NoneTRS A1001 (-2.9A)TRS A1001 ( 4.1A)NoneTRS A1001 (-4.9A)NoneTRS A1001 (-4.5A)TRS A1001 (-4.0A) | 0.79A | 6ca1B-5dkxA:33.0 | 6ca1B-5dkxA:7.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f7c | ALPHA-GLUCOSIDASE (Bacteroidesthetaiotaomicron) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2) | 7 | ASP A 348ASP A 460ARG A 507TRP A 520ASP A 523PHE A 556HIS A 588 | None | 0.33A | 6ca1B-5f7cA:36.7 | 6ca1B-5f7cA:8.36 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f7s | GLYCOSIDE HYDROLASEFAMILY 31 (Trueperellapyogenes) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2) | 6 | ASP A 467ARG A 516TRP A 529ASP A 532PHE A 565HIS A 591 | CA A 805 (-2.9A) CA A 805 ( 4.6A)None CA A 805 ( 4.6A)NoneNone | 0.51A | 6ca1B-5f7sA:34.6 | 6ca1B-5f7sA:7.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f7u | CYCLOALTERNAN-FORMING ENZYME (Listeriamonocytogenes) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2)PF16338(DUF4968)PF16990(CBM_35) | 5 | ARG A 614TRP A 627ASP A 630PHE A 663HIS A 689 | GLC A1116 (-2.8A)GLC A1117 (-4.6A)GLC A1117 (-2.7A)GLC A1116 (-4.6A)GLC A1117 (-4.1A) | 0.65A | 6ca1B-5f7uA:33.3 | 6ca1B-5f7uA:6.14 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hjr | NEUTRALALPHA-GLUCOSIDASE AB (Mus musculus) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2) | 9 | ASP A 451ILE A 488ASP A 564MET A 565ARG A 624TRP A 637ASP A 640PHE A 673HIS A 698 | 5GF A1021 (-2.0A)None5GF A1021 (-2.1A)5GF A1021 (-2.6A)5GF A1021 (-3.4A)5GF A1021 ( 4.6A)5GF A1021 (-2.6A)5GF A1021 (-3.6A)5GF A1021 (-4.0A) | 1.21A | 6ca1B-5hjrA:39.8 | 6ca1B-5hjrA:7.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hjr | NEUTRALALPHA-GLUCOSIDASE AB (Mus musculus) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2) | 11 | TRP A 423ASP A 451ILE A 452ILE A 488ASP A 564MET A 565ARG A 624TRP A 637ASP A 640PHE A 673HIS A 698 | 5GF A1021 (-3.1A)5GF A1021 (-2.0A)5GF A1021 (-3.6A)None5GF A1021 (-2.1A)5GF A1021 (-2.6A)5GF A1021 (-3.4A)5GF A1021 ( 4.6A)5GF A1021 (-2.6A)5GF A1021 (-3.6A)5GF A1021 (-4.0A) | 0.48A | 6ca1B-5hjrA:39.8 | 6ca1B-5hjrA:7.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hjr | NEUTRALALPHA-GLUCOSIDASE AB (Mus musculus) |
PF01055(Glyco_hydro_31)PF13802(Gal_mutarotas_2) | 8 | TRP A 423ASP A 451ILE A 452ILE A 488TRP A 562TRP A 637PHE A 673HIS A 698 | 5GF A1021 (-3.1A)5GF A1021 (-2.0A)5GF A1021 (-3.6A)None5GF A1021 (-4.6A)5GF A1021 ( 4.6A)5GF A1021 (-3.6A)5GF A1021 (-4.0A) | 0.85A | 6ca1B-5hjrA:39.8 | 6ca1B-5hjrA:7.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jou | ALPHA-XYLOSIDASEBOGH31A (Bacteroidesovatus) |
PF01055(Glyco_hydro_31)PF16338(DUF4968)PF17137(DUF5110) | 8 | TRP A 442ASP A 441ASP A 553ARG A 613TRP A 627ASP A 630PHE A 663HIS A 709 | EDO A1008 (-3.7A)EDO A1008 (-2.8A)EDO A1008 (-2.7A)EDO A1008 (-4.6A)NoneEDO A1008 (-3.0A)EDO A1008 (-4.3A)EDO A1008 (-4.0A) | 0.74A | 6ca1B-5jouA:10.2 | 6ca1B-5jouA:7.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5jou | ALPHA-XYLOSIDASEBOGH31A (Bacteroidesovatus) |
PF01055(Glyco_hydro_31)PF16338(DUF4968)PF17137(DUF5110) | 6 | TRP A 442ASP A 441TRP A 551ASP A 553PHE A 663HIS A 709 | EDO A1008 (-3.7A)EDO A1008 (-2.8A)NoneEDO A1008 (-2.7A)EDO A1008 (-4.3A)EDO A1008 (-4.0A) | 1.13A | 6ca1B-5jouA:10.2 | 6ca1B-5jouA:7.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nn8 | LYSOSOMALALPHA-GLUCOSIDASE (Homo sapiens) |
no annotation | 6 | ASP A 404ILE A 441MET A 519ARG A 600ASP A 616PHE A 649 | ACR A1015 (-3.0A)ACR A1015 (-4.3A)ACR A1015 (-3.3A)ACR A1015 (-3.1A)ACR A1015 (-2.7A)ACR A1015 (-4.3A) | 1.47A | 6ca1B-5nn8A:41.7 | 6ca1B-5nn8A:8.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nn8 | LYSOSOMALALPHA-GLUCOSIDASE (Homo sapiens) |
no annotation | 10 | TRP A 376ASP A 404ILE A 441ASP A 518MET A 519ARG A 600TRP A 613ASP A 616PHE A 649HIS A 674 | ACR A1015 ( 4.6A)ACR A1015 (-3.0A)ACR A1015 (-4.3A)ACR A1015 (-3.1A)ACR A1015 (-3.3A)ACR A1015 (-3.1A)ACR A1015 (-4.8A)ACR A1015 (-2.7A)ACR A1015 (-4.3A)ACR A1015 (-4.0A) | 0.64A | 6ca1B-5nn8A:41.7 | 6ca1B-5nn8A:8.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5nn8 | LYSOSOMALALPHA-GLUCOSIDASE (Homo sapiens) |
no annotation | 6 | TRP A 376ASP A 404ILE A 441TRP A 516PHE A 649HIS A 674 | ACR A1015 ( 4.6A)ACR A1015 (-3.0A)ACR A1015 (-4.3A)NoneACR A1015 (-4.3A)ACR A1015 (-4.0A) | 0.96A | 6ca1B-5nn8A:41.7 | 6ca1B-5nn8A:8.49 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x3j | GLYCOSIDE HYDROLASEFAMILY 31 (Kribbellaflavida) |
no annotation | 5 | ARG A 500TRP A 513ASP A 516PHE A 549HIS A 575 | GLC A 819 ( 2.9A)GLC A 822 ( 4.6A)GLC A 822 ( 2.8A)GLC A 822 ( 4.8A)GLC A 822 ( 4.0A) | 0.59A | 6ca1B-5x3jA:30.4 | 6ca1B-5x3jA:16.84 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5x7s | GLYCOSIDE HYDROLASEFAMILY 31ALPHA-GLUCOSIDASE (Paenibacillussp. 598K) |
PF01055(Glyco_hydro_31)PF16338(DUF4968)PF16990(CBM_35)PF17137(DUF5110) | 6 | ASP A 429ARG A 474TRP A 488ASP A 491PHE A 533HIS A 565 | None | 0.39A | 6ca1B-5x7sA:21.4 | 6ca1B-5x7sA:5.04 |