SIMILAR PATTERNS OF AMINO ACIDS FOR 6C9X_B_VOGB701

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3n ALPHA-GLUCOSIDASE

(Sulfolobus
solfataricus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		10 ASP A  87
ILE A 213
ILE A 249
TRP A 284
ASP A 320
MET A 321
ARG A 400
TRP A 413
PHE A 449
HIS A 480
 BOG  A2000 (-2.7A)
None
None
None
None
BOG  A2000 ( 4.0A)
BOG  A2000 (-3.1A)
None
None
None
 0.49A 6c9xB-2g3nA:
42.7		 6c9xB-2g3nA:
27.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3n ALPHA-GLUCOSIDASE

(Sulfolobus
solfataricus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		6 ASP A  87
ILE A 249
MET A 321
ARG A 400
PHE A 449
HIS A 480
 BOG  A2000 (-2.7A)
None
BOG  A2000 ( 4.0A)
BOG  A2000 (-3.1A)
None
None
 1.18A 6c9xB-2g3nA:
42.7		 6c9xB-2g3nA:
27.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g3n ALPHA-GLUCOSIDASE

(Sulfolobus
solfataricus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		7 ILE A 213
ILE A 249
TRP A 284
TRP A 318
TRP A 413
PHE A 449
HIS A 480
 None
 1.01A 6c9xB-2g3nA:
42.7		 6c9xB-2g3nA:
27.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iic ALPHA-11 GIARDIN

(Giardia
intestinalis) 		no annotation 5 ASP A  89
ILE A 220
ILE A  99
ASP A  95
ARG A 254
 None
 1.29A 6c9xB-2iicA:
undetectable		 6c9xB-2iicA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1

(Gracilariopsis
lemaneiformis) 		PF01055
(Glyco_hydro_31) 		7 ASP A 239
ASP A 553
MET A 554
ARG A 649
TRP A 662
PHE A 698
HIS A 731
 QPS  A1050 (-2.5A)
QPS  A1050 (-3.1A)
QPS  A1050 (-3.1A)
QPS  A1050 (-3.2A)
QPS  A1050 (-4.6A)
QPS  A1050 (-4.3A)
QPS  A1050 (-4.3A)
 0.54A 6c9xB-2x2iA:
33.4		 6c9xB-2x2iA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xvg ALPHA XYLOSIDASE

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		5 ASP A 582
ARG A 642
TRP A 656
PHE A 692
HIS A 740
 None
 0.50A 6c9xB-2xvgA:
34.0		 6c9xB-2xvgA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctt MALTASE-GLUCOAMYLASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		10 ASP A 203
ILE A 328
ILE A 364
TRP A 406
ASP A 443
MET A 444
ARG A 526
TRP A 539
PHE A 575
HIS A 600
 GOL  A3001 (-2.6A)
3CU  A1001 ( 3.9A)
3CU  A1001 (-4.5A)
None
3CU  A1001 (-2.7A)
3CU  A1001 ( 3.9A)
3CU  A1001 ( 3.5A)
3CU  A1001 (-4.6A)
3CU  A1001 (-4.5A)
3CU  A1001 (-3.9A)
 0.41A 6c9xB-3cttA:
35.7		 6c9xB-3cttA:
25.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctt MALTASE-GLUCOAMYLASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		6 ASP A 203
ILE A 364
MET A 444
ARG A 526
PHE A 575
HIS A 600
 GOL  A3001 (-2.6A)
3CU  A1001 (-4.5A)
3CU  A1001 ( 3.9A)
3CU  A1001 ( 3.5A)
3CU  A1001 (-4.5A)
3CU  A1001 (-3.9A)
 1.27A 6c9xB-3cttA:
35.7		 6c9xB-3cttA:
25.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctt MALTASE-GLUCOAMYLASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		6 ILE A 328
ILE A 364
TRP A 406
TRP A 441
PHE A 575
HIS A 600
 3CU  A1001 ( 3.9A)
3CU  A1001 (-4.5A)
None
3CU  A1001 (-4.9A)
3CU  A1001 (-4.5A)
3CU  A1001 (-3.9A)
 0.94A 6c9xB-3cttA:
35.7		 6c9xB-3cttA:
25.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpp SUCRASE-ISOMALTASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		6 ASP A 231
ILE A 392
MET A 473
ARG A 555
PHE A 604
HIS A 629
 None
None
TRS  A6001 ( 3.7A)
TRS  A6001 ( 4.6A)
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 1.17A 6c9xB-3lppA:
37.7		 6c9xB-3lppA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpp SUCRASE-ISOMALTASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		11 ASP A 231
TRP A 327
ILE A 356
ILE A 392
TRP A 435
ASP A 472
MET A 473
ARG A 555
TRP A 568
PHE A 604
HIS A 629
 None
TRS  A6001 ( 3.8A)
TRS  A6001 ( 4.0A)
None
TRS  A6001 ( 4.6A)
TRS  A6001 (-3.2A)
TRS  A6001 ( 3.7A)
TRS  A6001 ( 4.6A)
None
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 0.36A 6c9xB-3lppA:
37.7		 6c9xB-3lppA:
24.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lpp SUCRASE-ISOMALTASE

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		8 TRP A 327
ILE A 356
ILE A 392
TRP A 435
TRP A 470
TRP A 568
PHE A 604
HIS A 629
 TRS  A6001 ( 3.8A)
TRS  A6001 ( 4.0A)
None
TRS  A6001 ( 4.6A)
None
None
TRS  A6001 (-4.4A)
TRS  A6001 (-4.2A)
 0.86A 6c9xB-3lppA:
37.7		 6c9xB-3lppA:
24.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3poc ALPHA-GLUCOSIDASE

(Blautia obeum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		11 ASP A  73
TRP A 169
ILE A 198
ILE A 234
TRP A 271
TRP A 305
MET A 308
ARG A 404
TRP A 417
PHE A 453
HIS A 478
 None
ACR  A 664 (-3.7A)
ACR  A 664 (-3.5A)
None
ACR  A 664 (-4.6A)
None
ACR  A 664 ( 3.8A)
ACR  A 664 (-4.0A)
ACR  A 664 (-4.6A)
ACR  A 664 (-4.4A)
ACR  A 664 (-4.2A)
 0.19A 6c9xB-3pocA:
62.9		 6c9xB-3pocA:
99.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3top MALTASE-GLUCOAMYLASE
, INTESTINAL

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		10 ASP A1157
ILE A1280
ILE A1315
TRP A1355
ASP A1420
MET A1421
ARG A1510
TRP A1523
PHE A1559
HIS A1584
 ACR  A   1 (-2.6A)
ACR  A   1 (-4.1A)
None
ACR  A   1 (-4.4A)
ACR  A   1 (-3.6A)
ACR  A   1 (-3.5A)
ACR  A   1 (-2.9A)
ACR  A   1 (-4.5A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 0.42A 6c9xB-3topA:
37.4		 6c9xB-3topA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3top MALTASE-GLUCOAMYLASE
, INTESTINAL

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		5 ASP A1157
ILE A1280
MET A1421
PHE A1559
HIS A1584
 ACR  A   1 (-2.6A)
ACR  A   1 (-4.1A)
ACR  A   1 (-3.5A)
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 1.39A 6c9xB-3topA:
37.4		 6c9xB-3topA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3top MALTASE-GLUCOAMYLASE
, INTESTINAL

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		5 ASP A1157
ILE A1315
MET A1421
ARG A1510
PHE A1559
 ACR  A   1 (-2.6A)
None
ACR  A   1 (-3.5A)
ACR  A   1 (-2.9A)
ACR  A   1 (-4.3A)
 1.14A 6c9xB-3topA:
37.4		 6c9xB-3topA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3top MALTASE-GLUCOAMYLASE
, INTESTINAL

(Homo sapiens) 		PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N) 		6 ILE A1280
ILE A1315
TRP A1355
TRP A1418
PHE A1559
HIS A1584
 ACR  A   1 (-4.1A)
None
ACR  A   1 (-4.4A)
None
ACR  A   1 (-4.3A)
ACR  A   1 (-3.9A)
 0.94A 6c9xB-3topA:
37.4		 6c9xB-3topA:
24.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wel ALPHA-GLUCOSIDASE

(Beta vulgaris) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16863
(NtCtMGAM_N) 		5 ASP A 232
ILE A 358
MET A 470
PHE A 601
HIS A 626
 ACR  A1001 (-2.7A)
ACR  A1001 (-3.6A)
ACR  A1001 (-3.3A)
ACR  A1001 (-4.3A)
ACR  A1001 (-4.1A)
 1.43A 6c9xB-3welA:
42.3		 6c9xB-3welA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wel ALPHA-GLUCOSIDASE

(Beta vulgaris) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16863
(NtCtMGAM_N) 		5 ASP A 232
ILE A 396
MET A 470
ARG A 552
PHE A 601
 ACR  A1001 (-2.7A)
ACR  A1001 (-4.9A)
ACR  A1001 (-3.3A)
ACR  A1001 (-3.0A)
ACR  A1001 (-4.3A)
 1.03A 6c9xB-3welA:
42.3		 6c9xB-3welA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wel ALPHA-GLUCOSIDASE

(Beta vulgaris) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16863
(NtCtMGAM_N) 		11 ASP A 232
TRP A 329
ILE A 358
ILE A 396
TRP A 432
ASP A 469
MET A 470
ARG A 552
TRP A 565
PHE A 601
HIS A 626
 ACR  A1001 (-2.7A)
ACR  A1001 (-4.1A)
ACR  A1001 (-3.6A)
ACR  A1001 (-4.9A)
ACR  A1001 ( 4.6A)
ACR  A1001 (-3.2A)
ACR  A1001 (-3.3A)
ACR  A1001 (-3.0A)
ACR  A1001 (-4.8A)
ACR  A1001 (-4.3A)
ACR  A1001 (-4.1A)
 0.43A 6c9xB-3welA:
42.3		 6c9xB-3welA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wel ALPHA-GLUCOSIDASE

(Beta vulgaris) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16863
(NtCtMGAM_N) 		8 TRP A 329
ILE A 358
ILE A 396
TRP A 432
TRP A 467
TRP A 565
PHE A 601
HIS A 626
 ACR  A1001 (-4.1A)
ACR  A1001 (-3.6A)
ACR  A1001 (-4.9A)
ACR  A1001 ( 4.6A)
None
ACR  A1001 (-4.8A)
ACR  A1001 (-4.3A)
ACR  A1001 (-4.1A)
 0.87A 6c9xB-3welA:
42.3		 6c9xB-3welA:
26.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9y ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF17137
(DUF5110) 		6 ILE A 341
ASP A 412
ARG A 463
TRP A 477
PHE A 513
HIS A 540
 None
 0.40A 6c9xB-4b9yA:
40.2		 6c9xB-4b9yA:
24.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b9y ALPHA-GLUCOSIDASE,
PUTATIVE, ADG31B

(Cellvibrio
japonicus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF17137
(DUF5110) 		5 ILE A 341
TRP A 410
TRP A 477
PHE A 513
HIS A 540
 None
 0.97A 6c9xB-4b9yA:
40.2		 6c9xB-4b9yA:
24.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		6 ASP A 303
ILE A 480
MET A 557
ARG A 617
PHE A 666
HIS A 691
 None
None
TRS  A1001 (-3.5A)
TRS  A1001 (-4.0A)
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 1.08A 6c9xB-5dkxA:
39.9		 6c9xB-5dkxA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		11 ASP A 303
TRP A 415
ILE A 444
ILE A 480
TRP A 517
ASP A 556
MET A 557
ARG A 617
TRP A 630
PHE A 666
HIS A 691
 None
None
TRS  A1001 ( 4.1A)
None
TRS  A1001 ( 4.9A)
TRS  A1001 (-3.2A)
TRS  A1001 (-3.5A)
TRS  A1001 (-4.0A)
None
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 0.46A 6c9xB-5dkxA:
39.9		 6c9xB-5dkxA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		8 TRP A 415
ILE A 444
ILE A 480
TRP A 517
TRP A 554
TRP A 630
PHE A 666
HIS A 691
 None
TRS  A1001 ( 4.1A)
None
TRS  A1001 ( 4.9A)
TRS  A1001 (-4.9A)
None
TRS  A1001 (-4.5A)
TRS  A1001 (-4.0A)
 0.87A 6c9xB-5dkxA:
39.9		 6c9xB-5dkxA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7c ALPHA-GLUCOSIDASE

(Bacteroides
thetaiotaomicron) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		6 ASP A 228
ASP A 460
ARG A 507
TRP A 520
PHE A 556
HIS A 588
 None
 0.31A 6c9xB-5f7cA:
34.1		 6c9xB-5f7cA:
23.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7s GLYCOSIDE HYDROLASE
FAMILY 31

(Trueperella
pyogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		5 ASP A 467
ARG A 516
TRP A 529
PHE A 565
HIS A 591
 CA  A 805 (-2.9A)
CA  A 805 ( 4.6A)
None
None
None
 0.46A 6c9xB-5f7sA:
36.0		 6c9xB-5f7sA:
23.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB

(Mus musculus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		7 ASP A 305
ILE A 488
MET A 565
ARG A 624
TRP A 637
PHE A 673
HIS A 698
 None
None
5GF  A1021 (-2.6A)
5GF  A1021 (-3.4A)
5GF  A1021 ( 4.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 1.07A 6c9xB-5hjrA:
36.6		 6c9xB-5hjrA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB

(Mus musculus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		11 ASP A 305
TRP A 423
ILE A 452
ILE A 488
TRP A 525
ASP A 564
MET A 565
ARG A 624
TRP A 637
PHE A 673
HIS A 698
 None
5GF  A1021 (-3.1A)
5GF  A1021 (-3.6A)
None
5GF  A1021 (-3.7A)
5GF  A1021 (-2.1A)
5GF  A1021 (-2.6A)
5GF  A1021 (-3.4A)
5GF  A1021 ( 4.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 0.54A 6c9xB-5hjrA:
36.6		 6c9xB-5hjrA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hjr NEUTRAL
ALPHA-GLUCOSIDASE AB

(Mus musculus) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		8 TRP A 423
ILE A 452
ILE A 488
TRP A 525
TRP A 562
TRP A 637
PHE A 673
HIS A 698
 5GF  A1021 (-3.1A)
5GF  A1021 (-3.6A)
None
5GF  A1021 (-3.7A)
5GF  A1021 (-4.6A)
5GF  A1021 ( 4.6A)
5GF  A1021 (-3.6A)
5GF  A1021 (-4.0A)
 0.94A 6c9xB-5hjrA:
36.6		 6c9xB-5hjrA:
26.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jou ALPHA-XYLOSIDASE
BOGH31A

(Bacteroides
ovatus) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF17137
(DUF5110) 		5 ASP A 553
ARG A 613
TRP A 627
PHE A 663
HIS A 709
 EDO  A1008 (-2.7A)
EDO  A1008 (-4.6A)
None
EDO  A1008 (-4.3A)
EDO  A1008 (-4.0A)
 0.33A 6c9xB-5jouA:
33.6		 6c9xB-5jouA:
23.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE

(Homo sapiens) 		no annotation 5 ASP A 282
ILE A 441
MET A 519
ARG A 600
PHE A 649
 ACR  A1015 (-2.6A)
ACR  A1015 (-4.3A)
ACR  A1015 (-3.3A)
ACR  A1015 (-3.1A)
ACR  A1015 (-4.3A)
 1.06A 6c9xB-5nn8A:
36.8		 6c9xB-5nn8A:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE

(Homo sapiens) 		no annotation 10 ASP A 282
TRP A 376
ILE A 441
TRP A 481
ASP A 518
MET A 519
ARG A 600
TRP A 613
PHE A 649
HIS A 674
 ACR  A1015 (-2.6A)
ACR  A1015 ( 4.6A)
ACR  A1015 (-4.3A)
ACR  A1015 ( 4.6A)
ACR  A1015 (-3.1A)
ACR  A1015 (-3.3A)
ACR  A1015 (-3.1A)
ACR  A1015 (-4.8A)
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
 0.70A 6c9xB-5nn8A:
36.8		 6c9xB-5nn8A:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE

(Homo sapiens) 		no annotation 6 TRP A 376
ILE A 441
TRP A 481
TRP A 516
PHE A 649
HIS A 674
 ACR  A1015 ( 4.6A)
ACR  A1015 (-4.3A)
ACR  A1015 ( 4.6A)
None
ACR  A1015 (-4.3A)
ACR  A1015 (-4.0A)
 1.06A 6c9xB-5nn8A:
36.8		 6c9xB-5nn8A:
24.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x7s GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE

(Paenibacillus
sp. 598K) 		PF01055
(Glyco_hydro_31)
PF16338
(DUF4968)
PF16990
(CBM_35)
PF17137
(DUF5110) 		5 ASP A 429
ARG A 474
TRP A 488
PHE A 533
HIS A 565
 None
 0.44A 6c9xB-5x7sA:
22.3		 6c9xB-5x7sA:
19.70