SIMILAR PATTERNS OF AMINO ACIDS FOR 6C71_B_NCTB501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b0k PROTEIN (ACONITASE)

(Sus scrofa)
PF00330
(Aconitase)
PF00694
(Aconitase_C)
4 LEU A  62
TYR A  44
GLU A  40
THR A  60
None
1.05A 6c71B-1b0kA:
0.0
6c71B-1b0kA:
8.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bon BOMBYXIN-II,BOMBYXIN
A-2
BOMBYXIN-II,BOMBYXIN
A-6


(Bombyx mori)
PF00049
(Insulin)
no annotation
4 LEU B  15
TYR A  19
GLU A   5
THR B  14
None
1.02A 6c71B-1bonB:
undetectable
6c71B-1bonB:
15.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ccw PROTEIN (GLUTAMATE
MUTASE)


(Clostridium
cochlearium)
PF06368
(Met_asp_mut_E)
4 LEU B  39
TYR B  38
GLU B 140
THR B 168
None
1.23A 6c71B-1ccwB:
undetectable
6c71B-1ccwB:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cvm PHYTASE

(Bacillus
amyloliquefaciens)
PF02333
(Phytase)
4 LEU A  80
TYR A 132
GLU A 130
THR A  74
None
1.25A 6c71B-1cvmA:
undetectable
6c71B-1cvmA:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5u INTIMIN

(Escherichia
coli)
PF02368
(Big_2)
PF07979
(Intimin_C)
4 TYR I 163
GLU I 123
THR I 184
ASN I 120
None
1.21A 6c71B-1e5uI:
undetectable
6c71B-1e5uI:
19.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gnx BETA-GLUCOSIDASE

(Streptomyces
sp.)
PF00232
(Glyco_hydro_1)
4 LEU A 136
GLU A 139
THR A 151
TRP A  94
None
1.21A 6c71B-1gnxA:
undetectable
6c71B-1gnxA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gqj ALPHA-D-GLUCURONIDAS
E


(Cellvibrio
japonicus)
PF03648
(Glyco_hydro_67N)
PF07477
(Glyco_hydro_67C)
PF07488
(Glyco_hydro_67M)
4 LEU A 125
TYR A 126
GLU A  99
THR A  41
None
1.07A 6c71B-1gqjA:
undetectable
6c71B-1gqjA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ia7 CELLULASE CEL9M

([Clostridium]
cellulolyticum)
PF00759
(Glyco_hydro_9)
4 LEU A 167
TRP A 219
THR A 163
ASN A 225
None
1.16A 6c71B-1ia7A:
undetectable
6c71B-1ia7A:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jfr LIPASE

(Streptomyces
exfoliatus)
PF03403
(PAF-AH_p_II)
4 LEU A 165
GLU A 139
THR A 169
ASN A 157
None
1.15A 6c71B-1jfrA:
undetectable
6c71B-1jfrA:
17.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k1x 4-ALPHA-GLUCANOTRANS
FERASE


(Thermococcus
litoralis)
PF03065
(Glyco_hydro_57)
PF09094
(DUF1925)
PF09095
(DUF1926)
4 LEU A 643
GLU A 497
TRP A 617
THR A 641
None
1.14A 6c71B-1k1xA:
undetectable
6c71B-1k1xA:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kaq NICOTINATE-NUCLEOTID
E
ADENYLYLTRANSFERASE


(Bacillus
subtilis)
PF01467
(CTP_transf_like)
4 LEU A 186
TYR A 180
GLU A  58
THR A  51
None
1.20A 6c71B-1kaqA:
undetectable
6c71B-1kaqA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l7b DNA LIGASE

(Thermus
thermophilus)
PF00533
(BRCT)
4 LEU A  78
TYR A  75
GLU A  87
THR A  82
None
1.21A 6c71B-1l7bA:
undetectable
6c71B-1l7bA:
24.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m53 ISOMALTULOSE
SYNTHASE


(Klebsiella sp.
LX3)
PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C)
4 TRP A  48
TYR A 520
GLU A  50
TRP A 360
None
1.05A 6c71B-1m53A:
undetectable
6c71B-1m53A:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1paq TRANSLATION
INITIATION FACTOR
EIF-2B EPSILON
SUBUNIT


(Saccharomyces
cerevisiae)
PF02020
(W2)
4 LEU A 659
TRP A 696
THR A 693
TRP A 676
None
1.25A 6c71B-1paqA:
undetectable
6c71B-1paqA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1swf CIRCULARLY PERMUTED
CORE-STREPTAVIDIN
E51/A46


(Streptomyces
avidinii)
PF01382
(Avidin)
4 TYR A  43
TRP A  79
THR A  90
ASN A  23
None
1.24A 6c71B-1swfA:
undetectable
6c71B-1swfA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tzb GLUCOSE-6-PHOSPHATE
ISOMERASE,
CONJECTURAL


(Pyrobaculum
aerophilum)
PF10432
(bact-PGI_C)
4 GLU A 216
THR A 248
TRP A 221
ASN A 220
None
1.10A 6c71B-1tzbA:
undetectable
6c71B-1tzbA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uok OLIGO-1,6-GLUCOSIDAS
E


(Bacillus cereus)
PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C)
4 TRP A   6
TYR A 479
GLU A   8
TRP A 320
None
1.03A 6c71B-1uokA:
undetectable
6c71B-1uokA:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ak3 ADENYLATE KINASE
ISOENZYME-3


(Bos taurus)
PF00406
(ADK)
PF05191
(ADK_lid)
4 LEU A  87
GLU A  76
TRP A  85
ASN A  79
None
1.03A 6c71B-2ak3A:
undetectable
6c71B-2ak3A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bkx GLUCOSAMINE-6-PHOSPH
ATE DEAMINASE


(Bacillus
subtilis)
PF01182
(Glucosamine_iso)
4 LEU A  47
TYR A  44
THR A  20
ASN A  65
None
1.05A 6c71B-2bkxA:
undetectable
6c71B-2bkxA:
17.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cb5 PROTEIN (BLEOMYCIN
HYDROLASE)


(Homo sapiens)
PF03051
(Peptidase_C1_2)
4 TRP A 147
TYR A 254
GLU A 155
ASN A 263
None
1.09A 6c71B-2cb5A:
undetectable
6c71B-2cb5A:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d13 HYPOTHETICAL PROTEIN
PH1257


(Pyrococcus
horikoshii)
PF01902
(Diphthami_syn_2)
4 GLU A 106
TRP A 124
THR A 121
ASN A 110
None
1.14A 6c71B-2d13A:
undetectable
6c71B-2d13A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2db8 TRIPARTITE MOTIF
PROTEIN 9, ISOFORM 2


(Homo sapiens)
PF00041
(fn3)
4 LEU A  46
TYR A  60
GLU A  64
TRP A  31
None
1.25A 6c71B-2db8A:
undetectable
6c71B-2db8A:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0p ENDOGLUCANASE

(Ruminiclostridium
thermocellum)
PF12891
(Glyco_hydro_44)
4 TRP A 392
LEU A  72
TYR A  71
THR A  48
CTT  A 800 ( 3.9A)
None
CTT  A 800 (-3.7A)
None
1.10A 6c71B-2e0pA:
undetectable
6c71B-2e0pA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fj0 CARBOXYLIC ESTER
HYDROLASE


(Manduca sexta)
PF00135
(COesterase)
4 LEU A 163
GLU A 161
THR A 505
ASN A 482
None
1.08A 6c71B-2fj0A:
undetectable
6c71B-2fj0A:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ism PUTATIVE
OXIDOREDUCTASE


(Thermus
thermophilus)
PF07995
(GSDH)
4 TRP A  34
LEU A 207
GLU A 319
THR A 151
None
1.15A 6c71B-2ismA:
undetectable
6c71B-2ismA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nya PERIPLASMIC NITRATE
REDUCTASE


(Escherichia
coli)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
4 LEU A 544
GLU A 549
THR A 535
ASN A 411
None
1.16A 6c71B-2nyaA:
undetectable
6c71B-2nyaA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ph1 NUCLEOTIDE-BINDING
PROTEIN


(Archaeoglobus
fulgidus)
PF10609
(ParA)
4 LEU A  38
TYR A 244
GLU A 229
THR A  34
None
1.23A 6c71B-2ph1A:
undetectable
6c71B-2ph1A:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qdd MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME


(Roseovarius
nubinhibens)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 TYR A  57
GLU A 242
TRP A  53
ASN A 196
None
1.23A 6c71B-2qddA:
undetectable
6c71B-2qddA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v89 VDJ
RECOMBINATION-ACTIVA
TING PROTEIN 2


(Mus musculus)
PF13341
(RAG2_PHD)
4 LEU A1469
TYR A1476
THR A1465
ASN A1479
None
1.24A 6c71B-2v89A:
undetectable
6c71B-2v89A:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1


(Gracilariopsis
lemaneiformis)
PF01055
(Glyco_hydro_31)
4 LEU A 622
TRP A 535
THR A 626
ASN A 459
None
None
None
QPS  A1050 (-3.9A)
1.24A 6c71B-2x2iA:
undetectable
6c71B-2x2iA:
5.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z83 HELICASE/NUCLEOSIDE
TRIPHOSPHATASE


(Japanese
encephalitis
virus)
PF00271
(Helicase_C)
PF07652
(Flavi_DEAD)
4 TRP A 546
GLU A 439
TRP A 563
ASN A 554
None
1.21A 6c71B-2z83A:
undetectable
6c71B-2z83A:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ze0 ALPHA-GLUCOSIDASE

(Geobacillus sp.
HTA-462)
PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C)
4 TRP A   6
TYR A 471
GLU A   8
TRP A 317
None
1.09A 6c71B-2ze0A:
undetectable
6c71B-2ze0A:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bc9 ALPHA AMYLASE,
CATALYTIC REGION


(Halothermothrix
orenii)
PF00128
(Alpha-amylase)
PF09154
(DUF1939)
5 LEU A 537
TYR A 520
GLU A 511
THR A 472
ASN A 431
None
1.45A 6c71B-3bc9A:
undetectable
6c71B-3bc9A:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cbu PROBABLE GST-RELATED
PROTEIN


(Cupriavidus
pinatubonensis)
PF13410
(GST_C_2)
PF13417
(GST_N_3)
4 TYR A 106
GLU A  99
THR A 167
ASN A  11
None
1.24A 6c71B-3cbuA:
undetectable
6c71B-3cbuA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clw CONSERVED EXPORTED
PROTEIN


(Bacteroides
fragilis)
PF14587
(Glyco_hydr_30_2)
4 TRP A  51
LEU A 339
TYR A 302
ASN A 208
None
0.97A 6c71B-3clwA:
undetectable
6c71B-3clwA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clw CONSERVED EXPORTED
PROTEIN


(Bacteroides
fragilis)
PF14587
(Glyco_hydr_30_2)
4 TRP A  51
TYR A 302
GLU A 335
ASN A 208
None
1.19A 6c71B-3clwA:
undetectable
6c71B-3clwA:
9.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctt MALTASE-GLUCOAMYLASE

(Homo sapiens)
PF00088
(Trefoil)
PF01055
(Glyco_hydro_31)
PF16863
(NtCtMGAM_N)
4 LEU A 499
TYR A 502
GLU A 114
TRP A 490
None
1.05A 6c71B-3cttA:
undetectable
6c71B-3cttA:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE


(Streptococcus
pneumoniae)
PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C)
4 TYR A1158
GLU A1208
THR A1168
ASN A1177
None
1.13A 6c71B-3ecqA:
undetectable
6c71B-3ecqA:
4.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fai BETA-LACTAMASE

(Aeromonas
hydrophila)
PF00753
(Lactamase_B)
4 LEU A 161
TYR A  60
THR A 157
TRP A  87
None
1.21A 6c71B-3faiA:
undetectable
6c71B-3faiA:
18.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fg6 ADSEVERIN

(Homo sapiens)
PF00626
(Gelsolin)
4 LEU A 543
TYR A 551
GLU A 588
THR A 510
None
1.12A 6c71B-3fg6A:
undetectable
6c71B-3fg6A:
11.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbd SUCROSE ISOMERASE
SMUA FROM
PROTAMINOBACTER
RUBRUM


(Serratia
plymuthica)
PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C)
4 TRP A  21
TYR A 493
GLU A  23
TRP A 333
None
1.09A 6c71B-3gbdA:
undetectable
6c71B-3gbdA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hk0 GROWTH FACTOR
RECEPTOR-BOUND
PROTEIN 10


(Homo sapiens)
PF00169
(PH)
PF00788
(RA)
4 LEU A 345
TYR A 341
GLU A 170
ASN A 285
SCN  A  15 ( 4.8A)
None
None
None
1.09A 6c71B-3hk0A:
undetectable
6c71B-3hk0A:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxk SUGAR HYDROLASE

(Lactococcus
lactis)
PF00326
(Peptidase_S9)
4 LEU A 214
GLU A 182
THR A 188
ASN A 179
None
1.25A 6c71B-3hxkA:
undetectable
6c71B-3hxkA:
12.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldo 78 KDA
GLUCOSE-REGULATED
PROTEIN


(Homo sapiens)
PF00012
(HSP70)
4 LEU A 161
TYR A 160
GLU A  51
THR A  29
None
1.01A 6c71B-3ldoA:
undetectable
6c71B-3ldoA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1r FORMIMIDOYLGLUTAMASE

(Bacillus
subtilis)
PF00491
(Arginase)
4 LEU A 292
GLU A 287
THR A 291
ASN A 165
None
CL  A 320 ( 4.5A)
CL  A 321 (-3.3A)
CL  A 320 ( 4.7A)
1.14A 6c71B-3m1rA:
undetectable
6c71B-3m1rA:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m2p UDP-N-ACETYLGLUCOSAM
INE 4-EPIMERASE


(Bacillus cereus)
PF01370
(Epimerase)
4 LEU A  90
TYR A  91
THR A   6
ASN A 155
None
0.92A 6c71B-3m2pA:
undetectable
6c71B-3m2pA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pkz RECOMBINASE SIN

(Staphylococcus
aureus)
PF00239
(Resolvase)
4 LEU A  67
TYR A   5
GLU A  33
THR A  77
None
1.11A 6c71B-3pkzA:
undetectable
6c71B-3pkzA:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s4t AMIDOHYDROLASE 2

(Polaromonas sp.
JS666)
PF04909
(Amidohydro_2)
4 LEU A 212
TYR A 209
GLU A 152
TRP A 151
None
1.21A 6c71B-3s4tA:
undetectable
6c71B-3s4tA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3so4 METHIONINE-ADENOSYLT
RANSFERASE


(Entamoeba
histolytica)
PF00438
(S-AdoMet_synt_N)
PF02772
(S-AdoMet_synt_M)
PF02773
(S-AdoMet_synt_C)
4 LEU A 163
THR A 194
TRP A 162
ASN A 199
None
1.16A 6c71B-3so4A:
undetectable
6c71B-3so4A:
14.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tca AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER
1-INTERACTING
PROTEIN


(Mus musculus)
PF00169
(PH)
PF00788
(RA)
4 LEU A 426
TYR A 422
GLU A 241
ASN A 366
None
1.08A 6c71B-3tcaA:
undetectable
6c71B-3tcaA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkg DYNEIN HEAVY CHAIN,
CYTOPLASMIC


(Dictyostelium
discoideum)
PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9)
4 LEU A3802
TYR A3886
THR A3809
ASN A3937
None
1.24A 6c71B-3vkgA:
undetectable
6c71B-3vkgA:
2.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvo CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY


(Thermobifida
fusca)
PF09481
(CRISPR_Cse1)
4 LEU A 474
GLU A 482
THR A 418
TRP A 470
None
1.10A 6c71B-3wvoA:
undetectable
6c71B-3wvoA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wxm PROTEIN PELOTA
HOMOLOG


(Aeropyrum
pernix)
PF03463
(eRF1_1)
PF03465
(eRF1_3)
4 LEU B 120
GLU B 114
THR B  29
TRP B 112
None
1.25A 6c71B-3wxmB:
undetectable
6c71B-3wxmB:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x3y PHENYLETHYLAMINE
OXIDASE


(Arthrobacter
globiformis)
PF01179
(Cu_amine_oxid)
PF02728
(Cu_amine_oxidN3)
4 LEU A 426
THR A 408
TRP A 599
ASN A 203
None
1.06A 6c71B-3x3yA:
undetectable
6c71B-3x3yA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cbp NEURAL/ECTODERMAL
DEVELOPMENT FACTOR
IMP-L2


(Drosophila
melanogaster)
PF07679
(I-set)
4 TRP A  67
LEU A  43
GLU A  52
THR A 127
None
0.98A 6c71B-4cbpA:
undetectable
6c71B-4cbpA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecj GLUTATHIONE
S-TRANSFERASE


(Pseudomonas
aeruginosa)
PF00043
(GST_C)
PF02798
(GST_N)
4 LEU A   4
TYR A  26
GLU A  20
THR A   6
None
0.83A 6c71B-4ecjA:
undetectable
6c71B-4ecjA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f7k LACCASE

(uncultured
bacterium)
PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3)
4 TRP A 162
LEU A 280
TYR A 278
ASN A 188
None
1.16A 6c71B-4f7kA:
undetectable
6c71B-4f7kA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gn1 RAS-ASSOCIATED AND
PLECKSTRIN HOMOLOGY
DOMAINS-CONTAINING
PROTEIN 1


(Homo sapiens)
PF00169
(PH)
PF00788
(RA)
4 LEU A 509
TYR A 505
GLU A 331
ASN A 449
None
None
None
MLI  A 601 (-4.0A)
1.09A 6c71B-4gn1A:
undetectable
6c71B-4gn1A:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4igl YENC2

(Yersinia
entomophaga)
no annotation 4 LEU B 534
TYR B 229
GLU B 227
TRP B 539
None
1.23A 6c71B-4iglB:
undetectable
6c71B-4iglB:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ip4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN


(Ruegeria sp.
TM1040)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
4 LEU A 133
GLU A 141
TRP A 122
THR A 126
None
1.11A 6c71B-4ip4A:
undetectable
6c71B-4ip4A:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ivf PUTATIVE
UNCHARACTERIZED
PROTEIN


(Lodderomyces
elongisporus)
PF00043
(GST_C)
PF02798
(GST_N)
4 LEU A  10
TYR A  32
GLU A  26
THR A  12
None
0.90A 6c71B-4ivfA:
undetectable
6c71B-4ivfA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j9w PROLINE RACEMASE
FAMILY PROTEIN


(Pseudomonas
protegens)
PF05544
(Pro_racemase)
4 LEU A 247
GLU A 210
TRP A 259
ASN A 222
None
1.21A 6c71B-4j9wA:
undetectable
6c71B-4j9wA:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcc IRON-COMPOUND ABC
TRANSPORTER,
IRON-COMPOUND-BINDIN
G PROTEIN


(Streptococcus
pneumoniae)
PF01497
(Peripla_BP_2)
4 LEU A 301
TYR A 300
THR A  87
ASN A 204
None
0.99A 6c71B-4jccA:
undetectable
6c71B-4jccA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jej GERANYLGERANYLGLYCER
YL PHOSPHATE
SYNTHASE


(Flavobacterium
johnsoniae)
PF01884
(PcrB)
4 LEU A 102
TYR A 134
GLU A 180
THR A 151
PGE  A 302 ( 3.7A)
PGE  A 302 ( 4.0A)
1GP  A 301 (-2.1A)
PO4  A 303 (-4.0A)
1.13A 6c71B-4jejA:
undetectable
6c71B-4jejA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jo6 STREPTAVIDIN

(Streptomyces
avidinii)
PF01382
(Avidin)
4 TYR A  43
TRP A  79
THR A  90
ASN A  23
None
1.22A 6c71B-4jo6A:
undetectable
6c71B-4jo6A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kvg AMYLOID BETA A4
PRECURSOR
PROTEIN-BINDING
FAMILY B MEMBER
1-INTERACTING
PROTEIN


(Mus musculus)
PF00169
(PH)
PF00788
(RA)
4 LEU B 426
TYR B 422
GLU B 241
ASN B 366
None
1.06A 6c71B-4kvgB:
undetectable
6c71B-4kvgB:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8u OLIGO-1,6-GLUCOSIDAS
E 1


(Bacillus
subtilis)
PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C)
4 TRP A   5
TYR A 482
GLU A   7
TRP A 323
None
1.12A 6c71B-4m8uA:
undetectable
6c71B-4m8uA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p3z COPN

(Chlamydia
pneumoniae)
PF07201
(HrpJ)
4 LEU A 240
TYR A 207
GLU A 247
THR A 267
None
1.16A 6c71B-4p3zA:
undetectable
6c71B-4p3zA:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pcs ALPHA-L-FUCOSIDASE

(Bacteroides
thetaiotaomicron)
PF01120
(Alpha_L_fucos)
4 TRP A 117
LEU A 141
GLU A 163
TRP A 107
None
0.99A 6c71B-4pcsA:
undetectable
6c71B-4pcsA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdg PUTATIVE ADHESIN

(Bacteroides
thetaiotaomicron)
PF08842
(Mfa2)
4 LEU A 254
GLU A 304
THR A 251
ASN A 327
None
1.24A 6c71B-4qdgA:
undetectable
6c71B-4qdgA:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uym 14-ALPHA STEROL
DEMETHYLASE


(Aspergillus
fumigatus)
PF00067
(p450)
4 LEU A 473
TYR A 470
GLU A 466
THR A 315
None
None
None
HEM  A 580 ( 4.2A)
1.18A 6c71B-4uymA:
undetectable
6c71B-4uymA:
11.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xjn NUCLEOCAPSID

(Mammalian
rubulavirus 5)
PF00973
(Paramyxo_ncap)
4 LEU A 315
TYR A 312
GLU A 262
THR A 178
None
1.13A 6c71B-4xjnA:
undetectable
6c71B-4xjnA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yzo PUTATIVE ACYL-COA
ACYLTRANSFERASE


(Sulfurisphaera
tokodaii)
PF00108
(Thiolase_N)
PF02803
(Thiolase_C)
4 LEU A  62
TYR A  61
THR A  27
ASN A  18
None
0.79A 6c71B-4yzoA:
undetectable
6c71B-4yzoA:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zb6 PCURE2P4

(Phanerochaete
chrysosporium)
PF00043
(GST_C)
PF02798
(GST_N)
4 LEU A  10
TYR A  33
GLU A  27
THR A  12
None
1.07A 6c71B-4zb6A:
undetectable
6c71B-4zb6A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zb8 PCURE2P6

(Phanerochaete
chrysosporium)
PF00043
(GST_C)
PF02798
(GST_N)
4 LEU A   9
TYR A  32
GLU A  26
THR A  11
None
1.04A 6c71B-4zb8A:
undetectable
6c71B-4zb8A:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ziu UNCHARACTERIZED
LIPOPROTEIN YFHM


(Escherichia
coli)
PF07678
(A2M_comp)
4 LEU A1283
TYR A1286
GLU A1249
ASN A1237
None
1.24A 6c71B-4ziuA:
undetectable
6c71B-4ziuA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr8 UROPORPHYRINOGEN
DECARBOXYLASE


(Acinetobacter
baumannii)
PF01208
(URO-D)
4 LEU A 356
GLU A 320
THR A  21
ASN A 318
None
1.22A 6c71B-4zr8A:
undetectable
6c71B-4zr8A:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a42 UNCHARACTERIZED
LIPOPROTEIN YFHM


(Escherichia
coli)
PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF11974
(MG1)
4 LEU A1283
TYR A1286
GLU A1249
ASN A1237
None
1.20A 6c71B-5a42A:
undetectable
6c71B-5a42A:
4.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a55 ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE


(Streptococcus
pneumoniae)
PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C)
4 TYR A1158
GLU A1208
THR A1168
ASN A1177
None
1.21A 6c71B-5a55A:
undetectable
6c71B-5a55A:
5.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cx8 LIPOPROTEIN RAGB

(Porphyromonas
gingivalis)
PF07980
(SusD_RagB)
PF14322
(SusD-like_3)
4 TRP A 445
LEU A 330
THR A 429
TRP A 326
None
1.15A 6c71B-5cx8A:
undetectable
6c71B-5cx8A:
12.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1q PERIPLASMIC
DIPEPTIDE TRANSPORT
PROTEIN


(Yersinia pestis)
PF00496
(SBP_bac_5)
4 LEU A  78
GLU A  66
TRP A 233
THR A 210
None
1.15A 6c71B-5f1qA:
undetectable
6c71B-5f1qA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fn7 RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE C


(Homo sapiens)
PF12567
(CD45)
4 TYR A 123
THR A 162
TRP A 108
ASN A 110
None
1.02A 6c71B-5fn7A:
undetectable
6c71B-5fn7A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fod LEUCYL-TRNA
SYNTHETASE


(Plasmodium
falciparum)
no annotation 4 LEU A 278
TYR A 685
GLU A 687
ASN A 456
None
1.22A 6c71B-5fodA:
undetectable
6c71B-5fodA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsa CYP51 VARIANT1

(Candida
albicans)
PF00067
(p450)
4 LEU A 480
TYR A 477
GLU A 473
THR A 315
None
None
None
HEM  A 580 ( 4.6A)
1.24A 6c71B-5fsaA:
undetectable
6c71B-5fsaA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fv0 ESSC

(Geobacillus
thermodenitrificans)
PF01580
(FtsK_SpoIIIE)
4 LEU A1319
TYR A1322
GLU A1299
THR A1291
None
1.17A 6c71B-5fv0A:
undetectable
6c71B-5fv0A:
10.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jqx GLUCOSYL-3-PHOSPHOGL
YCERATE SYNTHASE


(Mycobacterium
tuberculosis)
PF00535
(Glycos_transf_2)
4 LEU A 160
TYR A 213
GLU A 232
THR A 239
None
1.24A 6c71B-5jqxA:
undetectable
6c71B-5jqxA:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kod INDOLE-3-ACETIC
ACID-AMIDO
SYNTHETASE GH3.5


(Arabidopsis
thaliana)
PF03321
(GH3)
4 TRP A 295
LEU A 219
GLU A 289
TRP A 303
None
1.01A 6c71B-5kodA:
undetectable
6c71B-5kodA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kz5 FRATAXIN,
MITOCHONDRIAL


(Homo sapiens)
PF01491
(Frataxin_Cyay)
4 TRP A 168
LEU A 203
TYR A 205
THR A 102
None
1.23A 6c71B-5kz5A:
undetectable
6c71B-5kz5A:
16.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l9w ACETOPHENONE
CARBOXYLASE GAMMA
SUBUNIT


(Aromatoleum
aromaticum)
PF01968
(Hydantoinase_A)
PF05378
(Hydant_A_N)
4 LEU B 251
TYR B 256
TRP B 248
THR B 247
None
1.20A 6c71B-5l9wB:
undetectable
6c71B-5l9wB:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ly9 VARIANT SURFACE
GLYCOPROTEIN MITAT
1.1


(Trypanosoma
brucei)
PF00913
(Trypan_glycop)
4 LEU A  68
TYR A  71
GLU A 267
THR A 312
None
GOL  A 408 (-4.1A)
None
GOL  A 408 (-3.3A)
1.21A 6c71B-5ly9A:
undetectable
6c71B-5ly9A:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6g BETA-GLUCOSIDASE

(Saccharopolyspora
erythraea)
no annotation 4 LEU A 556
GLU A 549
THR A 538
TRP A 587
None
0.90A 6c71B-5m6gA:
undetectable
6c71B-5m6gA:
9.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5thg I-ONUI_E-HCCR5

(synthetic
construct)
PF00961
(LAGLIDADG_1)
4 TRP A  64
LEU A  99
TYR A 107
THR A  19
None
1.02A 6c71B-5thgA:
undetectable
6c71B-5thgA:
11.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ttk AMINE OXIDASE

(Pseudomonas
putida)
PF01593
(Amino_oxidase)
4 TYR A 218
GLU A 249
THR A 381
TRP A 427
None
1.25A 6c71B-5ttkA:
64.7
6c71B-5ttkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ttk AMINE OXIDASE

(Pseudomonas
putida)
PF01593
(Amino_oxidase)
4 TYR A 218
THR A 381
TRP A 427
ASN A 462
None
None
None
FAD  A 501 (-3.8A)
0.55A 6c71B-5ttkA:
64.7
6c71B-5ttkA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u1s SEPARIN

(Saccharomyces
cerevisiae)
PF03568
(Peptidase_C50)
4 LEU A 939
TYR A 691
THR A 907
ASN A 726
None
1.14A 6c71B-5u1sA:
undetectable
6c71B-5u1sA:
3.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vbl APELIN
RECEPTOR,RUBREDOXIN,
APELIN RECEPTOR
CHIMERA


(Clostridium
pasteurianum;
Homo sapiens)
PF00001
(7tm_1)
PF00301
(Rubredoxin)
4 TRP B 154
LEU B 108
TYR B 107
THR B  77
None
0.78A 6c71B-5vblB:
undetectable
6c71B-5vblB:
15.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ve8 KAP123

(Kluyveromyces
lactis)
no annotation 4 LEU A 947
TYR A 943
THR A1001
ASN A 994
None
1.22A 6c71B-5ve8A:
undetectable
6c71B-5ve8A:
6.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vg9 PROTEIN-S-ISOPRENYLC
YSTEINE
O-METHYLTRANSFERASE


(Tribolium
castaneum)
no annotation 4 LEU A 198
TYR A 262
GLU A 251
THR A 200
SAH  A 301 (-4.4A)
None
None
None
1.23A 6c71B-5vg9A:
undetectable
6c71B-5vg9A:
27.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfu SPIKE PROTEIN

(Coronavirus
HKU15)
no annotation 4 LEU A 188
THR A 186
TRP A 396
ASN A 397
None
1.23A 6c71B-6bfuA:
undetectable
6c71B-6bfuA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f4f GLUTATHIONE
TRANSFERASE


(Trametes
versicolor)
no annotation 4 LEU A   9
TYR A  32
GLU A  26
THR A  11
None
0.94A 6c71B-6f4fA:
undetectable
6c71B-6f4fA:
26.19