SIMILAR PATTERNS OF AMINO ACIDS FOR 6C71_A_NCTA501

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bb0 IMIDAZOLONEPROPIONAS
E

(Bacillus
subtilis) 		PF01979
(Amidohydro_1) 		5 LEU A  71
TYR A 390
THR A  73
TRP A 354
ALA A 350
 None
 1.49A 6c71A-2bb0A:
0.0		 6c71A-2bb0A:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3anv D-SERINE DEHYDRATASE

(Gallus gallus) 		PF01168
(Ala_racemase_N)
PF14031
(D-ser_dehydrat) 		5 LEU A  55
GLU A 362
THR A  20
TRP A 370
ALA A 368
 None
 1.49A 6c71A-3anvA:
0.0		 6c71A-3anvA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bc9 ALPHA AMYLASE,
CATALYTIC REGION

(Halothermothrix
orenii) 		PF00128
(Alpha-amylase)
PF09154
(DUF1939) 		5 LEU A 537
TYR A 520
GLU A 511
THR A 472
ASN A 431
 None
 1.42A 6c71A-3bc9A:
0.1		 6c71A-3bc9A:
9.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyq MALONYL-COA LIGASE

(Streptomyces
coelicolor) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A 241
GLU A 246
THR A 276
ALA A 217
ASN A 221
 None
 1.40A 6c71A-3nyqA:
0.0		 6c71A-3nyqA:
10.36
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ttk AMINE OXIDASE

(Pseudomonas
putida) 		PF01593
(Amino_oxidase) 		5 TRP A 108
THR A 250
TRP A 427
ALA A 461
ASN A 462
 FAD  A 501 (-4.8A)
None
None
None
FAD  A 501 (-3.8A)
 0.74A 6c71A-5ttkA:
65.8		 6c71A-5ttkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ttk AMINE OXIDASE

(Pseudomonas
putida) 		PF01593
(Amino_oxidase) 		5 TYR A 218
GLU A 249
THR A 250
THR A 381
TRP A 427
 None
 1.47A 6c71A-5ttkA:
65.8		 6c71A-5ttkA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ttk AMINE OXIDASE

(Pseudomonas
putida) 		PF01593
(Amino_oxidase) 		6 TYR A 218
THR A 250
THR A 381
TRP A 427
ALA A 461
ASN A 462
 None
None
None
None
None
FAD  A 501 (-3.8A)
 0.66A 6c71A-5ttkA:
65.8		 6c71A-5ttkA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f4f GLUTATHIONE
TRANSFERASE

(Trametes
versicolor) 		no annotation 5 LEU A   9
TYR A  32
GLU A  26
THR A 219
THR A  11
 None
 1.12A 6c71A-6f4fA:
0.0		 6c71A-6f4fA:
26.19