SIMILAR PATTERNS OF AMINO ACIDS FOR 6C5U_B_RIOB600

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a2f DNA POLYMERASE

(Pyrococcus
furiosus) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 ASP A 315
TYR A 311
GLU A 288
GLU A 294
TYR A 291
 None
 1.38A 6c5uB-3a2fA:
0.0		 6c5uB-3a2fA:
18.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsr RIBONUCLEASE
INHIBITOR

(Mus musculus) 		PF13516
(LRR_6) 		5 GLU E 340
SER E 312
GLU E 283
GLU E 311
GLU E 369
 None
 1.39A 6c5uB-3tsrE:
0.0		 6c5uB-3tsrE:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r84 SIALYLTRANSFERASE
0160

(Photobacterium
damselae) 		PF11477
(PM0188) 		5 SER A 225
TYR A 196
GLU A 194
SER A 222
TYR A 139
 None
 1.41A 6c5uB-4r84A:
0.2		 6c5uB-4r84A:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xpr ALPHA-GLUCOSIDASE

(Pseudopedobacter
saltans) 		PF01055
(Glyco_hydro_31)
PF17137
(DUF5110) 		5 SER A  83
TYR A  88
SER A  79
GLU A  81
GLU A 191
 None
 1.30A 6c5uB-4xprA:
0.0		 6c5uB-4xprA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cey BIFUNCTIONAL AAC/APH

(Staphylococcus
aureus) 		no annotation 7 ASP A 374
SER A 376
TYR A 408
GLU A 411
SER A 413
GLU A 416
GLU A 445
 GNP  A 500 (-4.6A)
None
None
None
None
None
None
 0.70A 6c5uB-6ceyA:
43.3		 6c5uB-6ceyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cey BIFUNCTIONAL AAC/APH

(Staphylococcus
aureus) 		no annotation 7 ASP A 374
SER A 376
TYR A 408
GLU A 411
SER A 413
GLU A 416
TYR A 448
 GNP  A 500 (-4.6A)
None
None
None
None
None
None
 0.28A 6c5uB-6ceyA:
43.3		 6c5uB-6ceyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cey BIFUNCTIONAL AAC/APH

(Staphylococcus
aureus) 		no annotation 6 TYR A 408
GLU A 411
SER A 413
GLU A 415
GLU A 416
GLU A 445
 None
 1.00A 6c5uB-6ceyA:
43.3		 6c5uB-6ceyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cey BIFUNCTIONAL AAC/APH

(Staphylococcus
aureus) 		no annotation 6 TYR A 408
GLU A 411
SER A 413
GLU A 415
GLU A 416
TYR A 448
 None
 0.87A 6c5uB-6ceyA:
43.3		 6c5uB-6ceyA:
undetectable