SIMILAR PATTERNS OF AMINO ACIDS FOR 6C2M_D_SUED1202_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aei ANNEXIN XII

(Hydra vulgaris) 		PF00191
(Annexin) 		5 ILE A 214
GLY A 183
ARG A 191
ALA A 176
ALA A 175
 None
 1.02A 6c2mD-1aeiA:
undetectable		 6c2mD-1aeiA:
17.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aj8 CITRATE SYNTHASE

(Pyrococcus
furiosus) 		PF00285
(Citrate_synt) 		5 GLY A 283
ILE A 332
GLY A 316
PHE A 275
ALA A 181
 None
 0.90A 6c2mD-1aj8A:
undetectable		 6c2mD-1aj8A:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ccw PROTEIN (GLUTAMATE
MUTASE)

(Clostridium
cochlearium) 		PF06368
(Met_asp_mut_E) 		5 GLY B  27
ARG B 213
ILE B  95
GLY B 131
ALA B 159
 None
 1.05A 6c2mD-1ccwB:
0.0		 6c2mD-1ccwB:
11.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)

(Hepacivirus C) 		PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD) 		9 GLN A  41
HIS A  57
GLY A  58
VAL A  78
ARG A 123
GLY A 137
PHE A 154
ALA A 156
ALA A 157
 None
 0.64A 6c2mD-1cu1A:
34.4		 6c2mD-1cu1A:
47.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)

(Hepacivirus C) 		PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD) 		9 HIS A  57
GLY A  58
VAL A  78
ARG A 123
LYS A 136
GLY A 137
PHE A 154
ALA A 156
ALA A 157
 None
 0.52A 6c2mD-1cu1A:
34.4		 6c2mD-1cu1A:
47.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)

(Paracoccus
denitrificans) 		PF00766
(ETF_alpha)
PF01012
(ETF) 		5 GLN A 240
HIS A 264
GLY A 242
GLY A 224
ALA A 255
 FAD  A 399 (-3.9A)
FAD  A 399 (-3.9A)
FAD  A 399 (-3.1A)
None
None
 1.06A 6c2mD-1efpA:
undetectable		 6c2mD-1efpA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efp PROTEIN (ELECTRON
TRANSFER
FLAVOPROTEIN)

(Paracoccus
denitrificans) 		PF00766
(ETF_alpha)
PF01012
(ETF) 		5 GLN A 240
HIS A 264
GLY A 242
ILE A 212
ALA A 255
 FAD  A 399 (-3.9A)
FAD  A 399 (-3.9A)
FAD  A 399 (-3.1A)
None
None
 0.98A 6c2mD-1efpA:
undetectable		 6c2mD-1efpA:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1efv ELECTRON TRANSFER
FLAVOPROTEIN

(Homo sapiens) 		PF00766
(ETF_alpha)
PF01012
(ETF) 		5 GLN A 262
HIS A 286
GLY A 264
GLY A 246
ALA A 277
 FAD  A 599 (-3.8A)
FAD  A 599 (-3.8A)
FAD  A 599 (-3.1A)
None
None
 1.01A 6c2mD-1efvA:
undetectable		 6c2mD-1efvA:
10.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hlg LIPASE, GASTRIC

(Homo sapiens) 		PF00561
(Abhydrolase_1) 		5 GLY A 155
VAL A 318
ILE A  75
GLY A  97
ALA A  84
 None
 0.95A 6c2mD-1hlgA:
0.0		 6c2mD-1hlgA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9a ISOPENTENYL-DIPHOSPH
ATE DELTA-ISOMERASE

(Escherichia
coli) 		PF00293
(NUDIX) 		5 HIS A  69
GLY A  68
VAL A 117
ALA A  24
ALA A  23
 MN  A1001 (-3.1A)
None
None
None
None
 0.98A 6c2mD-1i9aA:
undetectable		 6c2mD-1i9aA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iab ASTACIN

(Astacus astacus) 		PF01400
(Astacin) 		5 GLN A  35
HIS A  87
GLY A  33
VAL A  85
ALA A 180
 None
 1.06A 6c2mD-1iabA:
undetectable		 6c2mD-1iabA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k8q TRIACYLGLYCEROL
LIPASE, GASTRIC

(Canis lupus) 		PF00561
(Abhydrolase_1) 		5 GLY A 155
VAL A 318
ILE A  75
GLY A  97
ALA A  84
 None
 1.00A 6c2mD-1k8qA:
0.0		 6c2mD-1k8qA:
12.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kcz BETA-METHYLASPARTASE

(Clostridium
tetanomorphum) 		PF05034
(MAAL_N)
PF07476
(MAAL_C) 		5 GLY A 354
ILE A 374
GLY A 379
ALA A 344
ALA A 342
 None
 1.08A 6c2mD-1kczA:
undetectable		 6c2mD-1kczA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfw CHITINASE B

(Arthrobacter
sp. TAD20) 		PF00704
(Glyco_hydro_18) 		5 GLY A 195
ILE A  58
GLY A 204
ALA A 146
ALA A 145
 None
 0.87A 6c2mD-1kfwA:
undetectable		 6c2mD-1kfwA:
12.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mc8 FLAP ENDONUCLEASE-1

(Pyrococcus
horikoshii) 		PF00752
(XPG_N)
PF00867
(XPG_I) 		5 GLY A 192
VAL A 201
ILE A  26
PHE A  35
ALA A  31
 None
 1.03A 6c2mD-1mc8A:
undetectable		 6c2mD-1mc8A:
13.17
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ns3 NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		8 GLN A  41
HIS A  57
GLY A  58
VAL A  78
ARG A 123
GLY A 137
ALA A 156
ALA A 157
 None
 0.85A 6c2mD-1ns3A:
30.4		 6c2mD-1ns3A:
39.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ns3 NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		8 HIS A  57
GLY A  58
VAL A  78
ARG A 123
GLY A 137
PHE A 154
ALA A 156
ALA A 157
 None
 0.63A 6c2mD-1ns3A:
30.4		 6c2mD-1ns3A:
39.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ns3 NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		5 HIS A  57
GLY A  58
VAL A  78
GLY A 137
ARG A 155
 None
 1.02A 6c2mD-1ns3A:
30.4		 6c2mD-1ns3A:
39.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ocm MALONAMIDASE E2

(Bradyrhizobium
japonicum) 		PF01425
(Amidase) 		5 VAL A  40
ILE A 157
GLY A 191
ALA A 136
ALA A 160
 None
 1.04A 6c2mD-1ocmA:
undetectable		 6c2mD-1ocmA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p43 ENOLASE 1

(Saccharomyces
cerevisiae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		5 GLN A 316
VAL A 145
ILE A 330
ALA A 359
ALA A 358
 None
 0.97A 6c2mD-1p43A:
undetectable		 6c2mD-1p43A:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q0u BSTDEAD

(Geobacillus
stearothermophilus) 		PF00270
(DEAD) 		5 GLY A 166
ILE A 111
GLY A 135
ALA A  79
ALA A  85
 None
 1.03A 6c2mD-1q0uA:
undetectable		 6c2mD-1q0uA:
19.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q7h CONSERVED
HYPOTHETICAL PROTEIN

(Thermoplasma
acidophilum) 		PF01472
(PUA)
PF09183
(DUF1947) 		5 GLY A  86
ILE A  94
ARG A 139
ALA A 138
ALA A 137
 None
 0.94A 6c2mD-1q7hA:
undetectable		 6c2mD-1q7hA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgd PROTEIN
(TRANSKETOLASE)

(Escherichia
coli) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 GLY A  65
VAL A 109
GLY A 154
ALA A 151
ALA A 180
 None
None
TPP  A 670 ( 4.1A)
None
None
 1.06A 6c2mD-1qgdA:
undetectable		 6c2mD-1qgdA:
8.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ser PROTEIN (SERYL-TRNA
SYNTHETASE
(E.C.6.1.1.11))

(Thermus
thermophilus) 		PF00587
(tRNA-synt_2b)
PF02403
(Seryl_tRNA_N) 		5 GLN A 356
GLY A 203
VAL A 212
LYS A 327
GLY A 326
 None
 1.08A 6c2mD-1serA:
undetectable		 6c2mD-1serA:
9.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u89 TALIN 1

(Mus musculus) 		no annotation 5 GLY A 761
ILE A 812
GLY A 817
ALA A 873
ALA A 874
 None
 1.06A 6c2mD-1u89A:
undetectable		 6c2mD-1u89A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v9c PRECORRIN-8X METHYL
MUTASE

(Thermus
thermophilus) 		PF02570
(CbiC) 		5 GLY A 208
ILE A 181
GLY A  59
ALA A 199
ALA A 196
 None
 0.95A 6c2mD-1v9cA:
undetectable		 6c2mD-1v9cA:
17.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wu0 ATP SYNTHASE C CHAIN

(Bacillus sp.
PS3) 		PF00137
(ATP-synt_C) 		5 GLY A  62
GLY A  15
ARG A  72
ALA A   9
ALA A   8
 None
 0.97A 6c2mD-1wu0A:
undetectable		 6c2mD-1wu0A:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z68 FIBROBLAST
ACTIVATION PROTEIN,
ALPHA SUBUNIT

(Homo sapiens) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 GLN A 483
ILE A 424
GLY A 479
ALA A 463
ALA A 453
 None
 0.98A 6c2mD-1z68A:
undetectable		 6c2mD-1z68A:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zxx 6-PHOSPHOFRUCTOKINAS
E

(Lactobacillus
delbrueckii) 		PF00365
(PFK) 		5 GLY A 254
ILE A 100
GLY A 138
ALA A  18
ALA A  19
 None
 1.00A 6c2mD-1zxxA:
undetectable		 6c2mD-1zxxA:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3z INDOLE-3-GLYCEROL
PHOSPHATE SYNTHASE

(Sulfolobus
solfataricus) 		PF00218
(IGPS) 		5 VAL A  78
ILE A 119
GLY A 153
ALA A 127
ALA A 122
 None
 1.05A 6c2mD-2c3zA:
undetectable		 6c2mD-2c3zA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d3t 3-KETOACYL-COA
THIOLASE

(Pseudomonas
fragi) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		5 GLY C  14
ILE C  72
GLY C 120
ALA C  36
ALA C  76
 None
 1.06A 6c2mD-2d3tC:
undetectable		 6c2mD-2d3tC:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dht 409AA LONG
HYPOTHETICAL
NADP-DEPENDENT
ISOCITRATE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00180
(Iso_dh) 		5 GLY A  97
VAL A 110
ARG A 149
ILE A 311
GLY A 346
 None
 1.08A 6c2mD-2dhtA:
undetectable		 6c2mD-2dhtA:
10.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ea3 CHYMOTRYPSIN

(Cellulomonas
bogoriensis) 		PF00089
(Trypsin) 		5 GLN A 167
ILE A 108
GLY A 149
ALA A  87
ALA A  88
 None
 0.90A 6c2mD-2ea3A:
4.7		 6c2mD-2ea3A:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fgy CARBOXYSOME SHELL
POLYPEPTIDE

(Halothiobacillus
neapolitanus) 		PF08936
(CsoSCA) 		5 GLY A 176
VAL A 295
ILE A 430
GLY A 435
ALA A 255
 None
 0.98A 6c2mD-2fgyA:
undetectable		 6c2mD-2fgyA:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fk5 FUCULOSE-1-PHOSPHATE
ALDOLASE

(Thermus
thermophilus) 		PF00596
(Aldolase_II) 		5 GLY A  27
ARG A 144
GLY A 152
ALA A 155
ALA A 145
 None
 1.00A 6c2mD-2fk5A:
undetectable		 6c2mD-2fk5A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftw DIHYDROPYRIMIDINE
AMIDOHYDROLASE

(Dictyostelium
discoideum) 		PF01979
(Amidohydro_1) 		5 HIS A 420
VAL A  79
ILE A 357
GLY A  92
ALA A 273
 None
 0.97A 6c2mD-2ftwA:
undetectable		 6c2mD-2ftwA:
11.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2isq CYSTEINE SYNTHASE

(Arabidopsis
thaliana) 		PF00291
(PALP) 		5 GLY A 225
GLY A 267
PHE A 295
ALA A 273
ALA A 274
 PLP  A 400 (-3.5A)
None
None
None
None
 0.96A 6c2mD-2isqA:
undetectable		 6c2mD-2isqA:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2naf PEPTIDYL-TRNA
HYDROLASE

(Mycolicibacterium
smegmatis) 		PF01195
(Pept_tRNA_hydro) 		5 HIS A  94
GLY A 114
VAL A 137
ILE A  90
GLY A 110
 None
 0.95A 6c2mD-2nafA:
undetectable		 6c2mD-2nafA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pfk 6-PHOSPHOFRUCTOKINAS
E ISOZYME I

(Escherichia
coli) 		PF00365
(PFK) 		5 GLY A 254
ILE A 100
GLY A 138
ALA A  18
ALA A  19
 None
 1.03A 6c2mD-2pfkA:
undetectable		 6c2mD-2pfkA:
14.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2poz PUTATIVE DEHYDRATASE

(Mesorhizobium
japonicum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A  35
ILE A  88
GLY A  38
ALA A  49
ALA A  47
 None
 1.03A 6c2mD-2pozA:
undetectable		 6c2mD-2pozA:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pro ALPHA-LYTIC PROTEASE

(Lysobacter
enzymogenes) 		PF02983
(Pro_Al_protease) 		6 VAL A 128
ARG A  82
ILE A  40
GLY A  45
ALA A  66
ALA A  65
 None
 1.25A 6c2mD-2proA:
undetectable		 6c2mD-2proA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qm8 GTPASE/ATPASE

(Methylobacterium
extorquens) 		PF03308
(ArgK) 		5 GLY A 242
ILE A 120
GLY A  76
ALA A 110
ALA A 113
 None
 1.06A 6c2mD-2qm8A:
undetectable		 6c2mD-2qm8A:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qz4 PARAPLEGIN

(Homo sapiens) 		PF00004
(AAA) 		5 GLY A 313
GLY A 518
PHE A 489
ARG A 486
ALA A 510
 None
ADP  A 700 (-3.4A)
None
None
None
 0.86A 6c2mD-2qz4A:
undetectable		 6c2mD-2qz4A:
17.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rhp THROMBOSPONDIN-2

(Homo sapiens) 		PF02412
(TSP_3)
PF05735
(TSP_C)
PF07645
(EGF_CA)
PF12947
(EGF_3) 		5 GLN A 728
GLY A 727
VAL A 980
GLY A 699
ALA A1109
 None
 1.06A 6c2mD-2rhpA:
undetectable		 6c2mD-2rhpA:
7.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v7z HEAT SHOCK COGNATE
71 KDA PROTEIN

(Rattus
norvegicus) 		PF00012
(HSP70) 		5 GLY A  12
ILE A 197
GLY A 338
ALA A 178
ALA A 179
 PO4  A1384 (-3.3A)
None
ADP  A1383 ( 4.4A)
None
None
 1.08A 6c2mD-2v7zA:
undetectable		 6c2mD-2v7zA:
11.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrc TRIPHENYLMETHANE
REDUCTASE

(Citrobacter sp.
MY-5) 		PF05368
(NmrA) 		5 GLY A  75
ARG A  50
ILE A  17
GLY A  10
ALA A  31
 None
 0.85A 6c2mD-2vrcA:
undetectable		 6c2mD-2vrcA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vrc TRIPHENYLMETHANE
REDUCTASE

(Citrobacter sp.
MY-5) 		PF05368
(NmrA) 		5 VAL A  91
ARG A  50
ILE A  17
GLY A  10
ALA A  31
 None
 0.95A 6c2mD-2vrcA:
undetectable		 6c2mD-2vrcA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wge 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 1

(Mycobacterium
tuberculosis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A 236
GLY A 318
PHE A 230
ALA A 338
ALA A 310
 None
TLM  A1424 ( 4.0A)
None
None
None
 1.06A 6c2mD-2wgeA:
undetectable		 6c2mD-2wgeA:
11.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0f PUTATIVE
PHOSPHOGLUCOMUTASE

(Thermus
thermophilus) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 GLY A  63
ILE A 157
GLY A 124
PHE A  86
ALA A  53
 None
 1.06A 6c2mD-2z0fA:
undetectable		 6c2mD-2z0fA:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5v ALPHA-GALACTOSIDASE

(Umbelopsis
vinacea) 		PF16499
(Melibiase_2) 		5 GLY A 271
ILE A  83
GLY A  12
ALA A  31
ALA A  32
 None
 1.04A 6c2mD-3a5vA:
undetectable		 6c2mD-3a5vA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bsx PUMILIO HOMOLOG 1

(Homo sapiens) 		PF00806
(PUF) 		5 GLY A 970
VAL A1009
ILE A 921
GLY A 934
ALA A 941
 None
 0.99A 6c2mD-3bsxA:
undetectable		 6c2mD-3bsxA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ecq ENDO-ALPHA-N-ACETYLG
ALACTOSAMINIDASE

(Streptococcus
pneumoniae) 		PF12905
(Glyco_hydro_101)
PF17451
(Glyco_hyd_101C) 		5 GLY A 241
VAL A 298
ARG A 234
ALA A 237
ALA A 236
 None
 0.99A 6c2mD-3ecqA:
undetectable		 6c2mD-3ecqA:
3.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fcn AN ALPHA-HELICAL
PROTEIN OF UNKNOWN
FUNCTION (PFAM01724)

(Rhodospirillum
rubrum) 		PF01724
(DUF29) 		5 GLY A 109
VAL A 116
ILE A  98
ARG A  62
ALA A  57
 None
 0.88A 6c2mD-3fcnA:
undetectable		 6c2mD-3fcnA:
17.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g6s PUTATIVE
ENDONUCLEASE/EXONUCL
EASE/PHOSPHATASE
FAMILY PROTEIN

(Bacteroides
vulgatus) 		PF03372
(Exo_endo_phos) 		5 GLN A  45
GLY A 171
ILE A  65
ALA A 134
ALA A 121
 None
 0.97A 6c2mD-3g6sA:
undetectable		 6c2mD-3g6sA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lq0 PROASTACIN

(Astacus astacus) 		PF01400
(Astacin) 		5 GLN A  35
HIS A  87
GLY A  33
VAL A  85
ALA A 180
 GOL  A 502 ( 4.8A)
None
None
None
None
 1.08A 6c2mD-3lq0A:
undetectable		 6c2mD-3lq0A:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pr4 DNA POLYMERASE IV

(Sulfolobus
solfataricus) 		PF00817
(IMS)
PF11798
(IMS_HHH) 		5 GLY A 162
ARG A 119
ILE A 111
GLY A 143
ALA A 121
 None
 0.93A 6c2mD-3pr4A:
undetectable		 6c2mD-3pr4A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qr3 ENDOGLUCANASE EG-II

(Trichoderma
reesei) 		PF00150
(Cellulase) 		5 GLY A  91
VAL A 141
GLY A  45
PHE A  50
ALA A 294
 None
 0.74A 6c2mD-3qr3A:
undetectable		 6c2mD-3qr3A:
12.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rim TRANSKETOLASE

(Mycobacterium
tuberculosis) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 GLY A 461
ILE A 515
GLY A 547
ALA A 478
ALA A 479
 None
 0.85A 6c2mD-3rimA:
undetectable		 6c2mD-3rimA:
7.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rko NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT J
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT K
NADH-QUINONE
OXIDOREDUCTASE
SUBUNIT N

(Escherichia
coli;
Escherichia
coli;
Escherichia
coli) 		no annotation
no annotation
no annotation 		5 VAL K  60
ILE J 111
GLY N 206
PHE N 172
ALA K  45
 None
 0.99A 6c2mD-3rkoK:
undetectable		 6c2mD-3rkoK:
20.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uko ALCOHOL
DEHYDROGENASE
CLASS-3

(Arabidopsis
thaliana) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 207
VAL A 186
ILE A 253
ALA A 281
ALA A 280
 None
 1.06A 6c2mD-3ukoA:
undetectable		 6c2mD-3ukoA:
11.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vex O-CARBAMOYLTRANSFERA
SE TOBZ

(Streptoalloteichus
tenebrarius) 		PF02543
(Carbam_trans_N)
PF16861
(Carbam_trans_C) 		5 GLY A 140
VAL A 161
GLY A  70
ALA A 119
ALA A 120
 CA0  A 602 ( 4.9A)
None
None
None
None
 1.00A 6c2mD-3vexA:
undetectable		 6c2mD-3vexA:
8.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wad GLYCOSYLTRANSFERASE

(Streptomyces
halstedii) 		PF06722
(DUF1205) 		5 GLY A 347
VAL A 364
ILE A 392
ALA A 359
ALA A 358
 None
 0.99A 6c2mD-3wadA:
undetectable		 6c2mD-3wadA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zz1 BETA-D-GLUCOSIDE
GLUCOHYDROLASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		6 GLY A 574
ILE A 621
GLY A 698
PHE A 669
ALA A 655
ALA A 667
 None
 1.20A 6c2mD-3zz1A:
undetectable		 6c2mD-3zz1A:
8.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c60 OCHRATOXINASE

(Aspergillus
niger) 		PF01979
(Amidohydro_1) 		6 GLY A 159
VAL A 244
ILE A 173
GLY A 136
ALA A 165
ALA A 167
 None
 1.36A 6c2mD-4c60A:
undetectable		 6c2mD-4c60A:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f3n UNCHARACTERIZED ACR,
COG1565 SUPERFAMILY

(Burkholderia
thailandensis) 		PF02636
(Methyltransf_28) 		5 VAL A 257
ILE A 394
PHE A 273
ALA A 272
ALA A 271
 None
 0.98A 6c2mD-4f3nA:
undetectable		 6c2mD-4f3nA:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fx5 VON WILLEBRAND
FACTOR TYPE A

(Catenulispora
acidiphila) 		PF13768
(VWA_3) 		5 GLY A 284
ILE A 179
GLY A 184
PHE A 186
ALA A 188
 None
 0.96A 6c2mD-4fx5A:
undetectable		 6c2mD-4fx5A:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jlw GLUTATHIONE-INDEPEND
ENT FORMALDEHYDE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A  48
ILE A 192
GLY A 301
ALA A 201
ALA A 202
 NAD  A 403 (-3.0A)
None
NAD  A 403 ( 3.7A)
None
None
 1.01A 6c2mD-4jlwA:
undetectable		 6c2mD-4jlwA:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jn6 4-HYDROXY-2-OXOVALER
ATE ALDOLASE

(Mycobacterium
tuberculosis) 		PF00682
(HMGL-like)
PF07836
(DmpG_comm) 		5 GLY A  17
VAL A 237
ARG A 227
ALA A 232
ALA A 280
 None
 1.04A 6c2mD-4jn6A:
undetectable		 6c2mD-4jn6A:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpu ELECTRON TRANSFER
FLAVOPROTEIN ALPHA
SUBUNIT

(Acidaminococcus
fermentans) 		PF00766
(ETF_alpha)
PF01012
(ETF) 		5 GLN A 266
HIS A 290
GLY A 268
GLY A 250
ALA A 281
 FAD  A 401 (-4.1A)
FAD  A 401 (-3.9A)
FAD  A 401 (-3.3A)
None
None
 1.06A 6c2mD-4kpuA:
undetectable		 6c2mD-4kpuA:
14.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nwk HCV NS3 1A PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		6 ARG A 123
ILE A 132
LYS A 136
GLY A 137
PHE A 154
ALA A 157
 None
2R8  A 301 (-4.3A)
GOL  A 310 ( 2.6A)
GOL  A 305 ( 3.2A)
2R8  A 301 (-3.7A)
2R8  A 301 (-3.8A)
 0.86A 6c2mD-4nwkA:
34.5		 6c2mD-4nwkA:
95.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nwk HCV NS3 1A PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		11 GLN A  41
HIS A  57
GLY A  58
VAL A  78
ILE A 132
LYS A 136
GLY A 137
PHE A 154
ARG A 155
ALA A 156
ALA A 157
 2R8  A 301 ( 3.5A)
2R8  A 301 (-3.3A)
2R8  A 301 (-3.5A)
None
2R8  A 301 (-4.3A)
GOL  A 310 ( 2.6A)
GOL  A 305 ( 3.2A)
2R8  A 301 (-3.7A)
2R8  A 301 (-3.6A)
2R8  A 301 (-3.1A)
2R8  A 301 (-3.8A)
 0.52A 6c2mD-4nwkA:
34.5		 6c2mD-4nwkA:
95.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rv1 ENGINEERED PROTEIN
OR497

(synthetic
construct) 		PF00514
(Arm) 		5 GLY A 200
ILE A 250
GLY A 242
ALA A 237
ALA A 277
 None
 1.07A 6c2mD-4rv1A:
undetectable		 6c2mD-4rv1A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rv1 ENGINEERED PROTEIN
OR497

(synthetic
construct) 		PF00514
(Arm) 		5 GLY A 242
ILE A 292
GLY A 284
ALA A 279
ALA A 319
 None
 1.01A 6c2mD-4rv1A:
undetectable		 6c2mD-4rv1A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rv1 ENGINEERED PROTEIN
OR497

(synthetic
construct) 		PF00514
(Arm) 		5 GLY A 284
ILE A 334
GLY A 326
ALA A 321
ALA A 361
 None
 1.01A 6c2mD-4rv1A:
undetectable		 6c2mD-4rv1A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rv1 ENGINEERED PROTEIN
OR497

(synthetic
construct) 		PF00514
(Arm) 		5 GLY A 326
ILE A 376
GLY A 368
ALA A 363
ALA A 403
 None
 1.05A 6c2mD-4rv1A:
undetectable		 6c2mD-4rv1A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trt DNA POLYMERASE III
SUBUNIT BETA

(Deinococcus
radiodurans) 		PF00712
(DNA_pol3_beta)
PF02767
(DNA_pol3_beta_2)
PF02768
(DNA_pol3_beta_3) 		5 GLY A 352
ARG A 174
ILE A 156
ALA A 176
ALA A 169
 None
 0.97A 6c2mD-4trtA:
undetectable		 6c2mD-4trtA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uqg DNA POLYMERASE

(Geobacillus
stearothermophilus) 		PF00476
(DNA_pol_A) 		5 GLY A 715
ARG A 703
ILE A 689
ALA A 707
ALA A 705
 None
 1.00A 6c2mD-4uqgA:
undetectable		 6c2mD-4uqgA:
9.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4woe TAUROCYAMINE KINASE

(Schistosoma
mansoni) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 HIS A 311
GLY A 309
ILE A 284
GLY A 306
ALA A 282
 None
 0.92A 6c2mD-4woeA:
0.0		 6c2mD-4woeA:
8.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xeu TRANSKETOLASE

(Pseudomonas
aeruginosa) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		5 GLY A  65
VAL A 109
GLY A 154
ALA A 151
ALA A 180
 None
 1.00A 6c2mD-4xeuA:
undetectable		 6c2mD-4xeuA:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dk6 5'-METHYLTHIOADENOSI
NE/S-ADENOSYLHOMOCYS
TEINE NUCLEOSIDASE

(Colwellia
psychrerythraea) 		PF01048
(PNP_UDP_1) 		5 GLY A 149
VAL A 196
ILE A 204
ARG A 199
ALA A  77
 None
None
None
None
ADE  A 302 (-4.9A)
 1.09A 6c2mD-5dk6A:
undetectable		 6c2mD-5dk6A:
17.24
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eqq NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		11 GLN A1041
HIS A1057
GLY A1058
VAL A1078
ARG A1123
ILE A1132
GLY A1137
PHE A1154
ARG A1155
ALA A1156
ALA A1157
 5RS  A1203 (-2.9A)
5RS  A1203 (-2.5A)
5RS  A1203 ( 2.9A)
5RS  A1203 (-3.9A)
5RS  A1203 ( 3.3A)
5RS  A1203 ( 4.1A)
5RS  A1203 (-3.2A)
5RS  A1203 (-3.3A)
5RS  A1203 (-4.8A)
5RS  A1203 (-2.9A)
5RS  A1203 (-3.5A)
 0.47A 6c2mD-5eqqA:
35.4		 6c2mD-5eqqA:
98.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5exe OXALATE
OXIDOREDUCTASE
SUBUNIT DELTA

(Moorella
thermoacetica) 		PF00037
(Fer4)
PF01558
(POR) 		5 GLY B 172
ILE B  69
GLY B 179
ALA B  38
ALA B  39
 None
 1.07A 6c2mD-5exeB:
undetectable		 6c2mD-5exeB:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i32 AQUAPORIN TIP2-1

(Arabidopsis
thaliana) 		PF00230
(MIP) 		5 GLY A  35
VAL A 128
ILE A 149
GLY A 182
ALA A 188
 None
 1.00A 6c2mD-5i32A:
undetectable		 6c2mD-5i32A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5im2 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL

(Rhodoferax
ferrireducens) 		PF03480
(DctP) 		5 GLN A 277
GLY A 147
ILE A 195
ALA A 208
ALA A 207
 BEZ  A 401 (-3.9A)
None
None
None
None
 0.71A 6c2mD-5im2A:
undetectable		 6c2mD-5im2A:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it0 PHOSPHOSERINE
PHOSPHATASE

(Mycobacterium
avium) 		PF12710
(HAD)
PF13740
(ACT_6) 		5 GLY A 139
ARG A 155
ILE A 358
ALA A 170
ALA A 372
 None
 1.02A 6c2mD-5it0A:
undetectable		 6c2mD-5it0A:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5joz NON-REDUCING END
ALPHA-L-ARABINOFURAN
OSIDASE BOGH43B

(Bacteroides
ovatus) 		PF04616
(Glyco_hydro_43) 		5 HIS A  77
GLY A  76
VAL A  51
ILE A 383
GLY A 342
 None
 1.06A 6c2mD-5jozA:
undetectable		 6c2mD-5jozA:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdj F5/8 TYPE C DOMAIN
PROTEIN

(Clostridium
perfringens) 		no annotation 6 VAL B 589
ILE B 613
GLY B 525
ARG B 529
ALA B 528
ALA B 616
 None
 1.36A 6c2mD-5kdjB:
undetectable		 6c2mD-5kdjB:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ktg GREEN FLUORESCENT
PROTEIN, BCL-2
HOMOLOGOUS
ANTAGONIST/KILLER

(Aequorea
victoria;
Mus musculus) 		PF00452
(Bcl-2)
PF01353
(GFP) 		5 GLY A 134
ARG A 168
ILE A  98
GLY A 104
ALA A 179
 None
 1.07A 6c2mD-5ktgA:
undetectable		 6c2mD-5ktgA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		5 GLN A1738
GLY A1741
VAL A1573
ALA A1401
ALA A1400
 None
 0.99A 6c2mD-5m59A:
undetectable		 6c2mD-5m59A:
4.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olc GALACTONATE
DEHYDRATASE

(Zobellia
galactanivorans) 		no annotation 5 GLY A 299
ILE A  59
GLY A  46
ALA A  96
ALA A  97
 None
 1.00A 6c2mD-5olcA:
undetectable		 6c2mD-5olcA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t5i TUNGSTEN-CONTAINING
FORMYLMETHANOFURAN
DEHYDROGENASE 2
SUBUNIT C

(Methanothermobacter
wolfeii) 		PF01493
(GXGXG) 		5 GLY C 118
VAL C  94
ILE C 192
GLY C 163
ALA C 158
 None
 1.00A 6c2mD-5t5iC:
undetectable		 6c2mD-5t5iC:
14.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u3f BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF01063
(Aminotran_4) 		5 GLY A  79
ARG A 108
GLY A 270
ALA A 203
ALA A 202
 7TS  A 400 (-3.1A)
None
7TS  A 400 (-3.4A)
None
None
 1.08A 6c2mD-5u3fA:
undetectable		 6c2mD-5u3fA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v72 NADPH-DEPENDENT
GLYOXYLATE/HYDROXYPY
RUVATE REDUCTASE

(Sinorhizobium
meliloti) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 GLY A  73
ILE A  12
GLY A  51
ALA A  68
ALA A  48
 None
 0.85A 6c2mD-5v72A:
undetectable		 6c2mD-5v72A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w76 ANCESTRAL ELOGATION
FACTOR N153

(synthetic
construct) 		no annotation 5 GLY A 340
ARG A  59
ARG A 378
ALA A 376
ALA A 386
 None
 1.05A 6c2mD-5w76A:
2.6		 6c2mD-5w76A:
22.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wdx JFH-1 NS3

(Hepacivirus C) 		no annotation 7 GLN A  41
HIS A  57
GLY A  58
GLY A 137
PHE A 154
ALA A 156
ALA A 157
 None
 0.62A 6c2mD-5wdxA:
27.2		 6c2mD-5wdxA:
37.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wdx JFH-1 NS3

(Hepacivirus C) 		no annotation 8 HIS A  57
GLY A  58
ARG A 123
ILE A 132
GLY A 137
PHE A 154
ALA A 156
ALA A 157
 None
 0.53A 6c2mD-5wdxA:
27.2		 6c2mD-5wdxA:
37.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs VP2

(Aquareovirus C) 		no annotation 5 GLY 2 649
VAL 2 633
ILE 2 540
GLY 2 627
ALA 2 514
 None
 0.99A 6c2mD-5zvs2:
undetectable		 6c2mD-5zvs2:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ayv FRUCTOSE-1,6-BISPHOS
PHATASE CLASS 2

(Mycobacterium
tuberculosis) 		no annotation 5 VAL A   4
ILE A 223
GLY A 220
ALA A 214
ALA A 213
 None
 1.03A 6c2mD-6ayvA:
undetectable		 6c2mD-6ayvA:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f8y THREONYLCARBAMOYL-AM
P SYNTHASE

(Pyrococcus
abyssi) 		no annotation 5 GLY A  26
ILE A 170
GLY A  40
ARG A  24
ALA A  20
 None
 1.00A 6c2mD-6f8yA:
undetectable		 6c2mD-6f8yA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fml RUVB-LIKE HELICASE

(Chaetomium
thermophilum) 		no annotation 5 GLY D  95
VAL D 291
ILE D  86
GLY D  29
ALA D  56
 None
 1.01A 6c2mD-6fmlD:
undetectable		 6c2mD-6fmlD:
22.09