SIMILAR PATTERNS OF AMINO ACIDS FOR 6C2M_C_SUEC1203_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1atg PERIPLASMIC
MOLYBDATE-BINDING
PROTEIN

(Azotobacter
vinelandii) 		PF13531
(SBP_bac_11) 		5 PHE A 163
GLY A 122
ILE A  80
LYS A  82
ASP A  57
 None
 1.32A 6c2mC-1atgA:
undetectable		 6c2mC-1atgA:
15.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)

(Hepacivirus C) 		PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD) 		5 PHE A  43
VAL A  55
GLY A  58
LEU A 135
ASP A 168
 None
 0.27A 6c2mC-1cu1A:
34.7		 6c2mC-1cu1A:
47.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fho UNC-89

(Caenorhabditis
elegans) 		no annotation 5 GLY A   8
ILE A  57
LEU A  59
LYS A  36
ARG A  12
 None
 1.15A 6c2mC-1fhoA:
0.0		 6c2mC-1fhoA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE

(Escherichia
coli) 		PF00982
(Glyco_transf_20) 		5 VAL A   6
GLY A  40
LEU A 117
LYS A 115
ASP A 124
 None
 1.20A 6c2mC-1gz5A:
undetectable		 6c2mC-1gz5A:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hbz CATALASE

(Micrococcus
luteus) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 GLY A 499
LEU A 454
LYS A 455
ARG A 458
ASP A 460
 None
 1.28A 6c2mC-1hbzA:
0.0		 6c2mC-1hbzA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htd ATROLYSIN C

(Crotalus atrox) 		PF01421
(Reprolysin) 		5 VAL A  33
ILE A 125
LEU A  97
ARG A  32
ASP A 128
 None
 1.45A 6c2mC-1htdA:
0.0		 6c2mC-1htdA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9c GLUTAMATE MUTASE

(Clostridium
cochlearium) 		PF02310
(B12-binding) 		5 PHE A 108
VAL A 116
ILE A  86
ARG A 115
ASP A 133
 None
 1.34A 6c2mC-1i9cA:
undetectable		 6c2mC-1i9cA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iip CYCLOPHILIN 40

(Bos taurus) 		PF00160
(Pro_isomerase)
PF13176
(TPR_7) 		5 ILE A 161
LEU A 162
LYS A 160
ARG A  31
ASP A  21
 None
 1.34A 6c2mC-1iipA:
undetectable		 6c2mC-1iipA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k72 ENDOGLUCANASE 9G

([Clostridium]
cellulolyticum) 		PF00759
(Glyco_hydro_9)
PF00942
(CBM_3) 		5 VAL A 261
HIS A 262
GLY A 264
LEU A  73
ASP A 424
 None
 1.21A 6c2mC-1k72A:
undetectable		 6c2mC-1k72A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k94 GRANCALCIN

(Homo sapiens) 		PF13202
(EF-hand_5)
PF13833
(EF-hand_8) 		5 PHE A 191
GLY A 213
ILE A  98
LEU A 101
ASP A 104
 None
 1.44A 6c2mC-1k94A:
undetectable		 6c2mC-1k94A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE

(Pseudomonas sp.
KKS102) 		PF00903
(Glyoxalase) 		5 VAL B  99
GLY B 118
ILE B 143
LEU B   5
ARG B  97
 None
 1.45A 6c2mC-1kwcB:
undetectable		 6c2mC-1kwcB:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l0w ASPARTYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		5 VAL A 150
HIS A 148
LEU A 535
ARG A 147
ASP A 530
 None
 1.32A 6c2mC-1l0wA:
undetectable		 6c2mC-1l0wA:
8.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ns3 NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		5 PHE A  43
VAL A  55
GLY A  58
ARG A 155
ASP A 168
 None
 1.28A 6c2mC-1ns3A:
30.6		 6c2mC-1ns3A:
39.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ns3 NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		5 PHE A  43
VAL A  55
GLY A  58
LEU A 135
ASP A 168
 None
 0.79A 6c2mC-1ns3A:
30.6		 6c2mC-1ns3A:
39.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o1z GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE

(Thermotoga
maritima) 		PF03009
(GDPD) 		5 VAL A 191
HIS A 164
GLY A 209
LEU A 217
ASP A 213
 None
 1.39A 6c2mC-1o1zA:
undetectable		 6c2mC-1o1zA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o8c YHDH

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 157
ILE A 298
LEU A 320
LYS A 296
ASP A  43
 NDP  A1325 (-3.1A)
None
None
None
None
 1.47A 6c2mC-1o8cA:
undetectable		 6c2mC-1o8cA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o8c YHDH

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 157
ILE A 298
LEU A 320
LYS A 296
ASP A  64
 NDP  A1325 (-3.1A)
None
None
None
None
 1.31A 6c2mC-1o8cA:
undetectable		 6c2mC-1o8cA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pyf IOLS PROTEIN

(Bacillus
subtilis) 		PF00248
(Aldo_ket_red) 		5 VAL A 173
GLY A   7
ILE A  16
LEU A 276
ASP A  53
 None
EDO  A 313 (-3.3A)
None
None
None
 1.44A 6c2mC-1pyfA:
undetectable		 6c2mC-1pyfA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5v CITE

(Mycobacterium
tuberculosis) 		PF03328
(HpcH_HpaI) 		5 HIS A 161
ILE A 108
LEU A 176
ARG A 163
ASP A 179
 None
 1.14A 6c2mC-1u5vA:
undetectable		 6c2mC-1u5vA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v3y PEPTIDE DEFORMYLASE

(Thermus
thermophilus) 		PF01327
(Pep_deformylase) 		5 VAL A 113
GLY A  98
LEU A 105
ARG A 158
ASP A 148
 None
None
OCS  A 102 ( 4.4A)
None
None
 1.45A 6c2mC-1v3yA:
undetectable		 6c2mC-1v3yA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wd5 HYPOTHETICAL PROTEIN
TT1426

(Thermus
thermophilus) 		PF00156
(Pribosyltran) 		5 VAL A  35
GLY A  29
LEU A 204
ARG A  32
ASP A 196
 None
 1.39A 6c2mC-1wd5A:
undetectable		 6c2mC-1wd5A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00348
(polyprenyl_synt) 		5 VAL A 101
HIS A 102
ILE A  78
LEU A  77
ASP A 115
 None
 1.15A 6c2mC-1wy0A:
undetectable		 6c2mC-1wy0A:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yre HYPOTHETICAL PROTEIN
PA3270

(Pseudomonas
aeruginosa) 		PF13302
(Acetyltransf_3) 		5 VAL A 185
GLY A 151
LEU A 118
LYS A 116
ASP A 125
 None
 1.29A 6c2mC-1yreA:
undetectable		 6c2mC-1yreA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zup HYPOTHETICAL PROTEIN
TM1739

(Thermotoga
maritima) 		PF09376
(NurA) 		5 VAL A 219
ILE A  41
LEU A  42
ARG A 200
ASP A 251
 None
 1.17A 6c2mC-1zupA:
undetectable		 6c2mC-1zupA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b7u CHARYBDIN

(Drimia maritima) 		PF00161
(RIP) 		5 HIS A  41
GLY A  42
ILE A  28
LEU A  31
LYS A  29
 None
 1.21A 6c2mC-2b7uA:
undetectable		 6c2mC-2b7uA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cjs UNC-13 HOMOLOG A

(Rattus
norvegicus) 		PF00168
(C2) 		5 PHE A  51
VAL A  28
ILE A   0
LEU A   1
ARG A  55
 None
 1.32A 6c2mC-2cjsA:
undetectable		 6c2mC-2cjsA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc4 165AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		PF01928
(CYTH) 		5 VAL A 117
GLY A 121
LEU A 158
LYS A 157
ASP A  33
 None
None
CL  A 501 (-4.0A)
None
None
 1.40A 6c2mC-2dc4A:
undetectable		 6c2mC-2dc4A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5x BUGD

(Bordetella
pertussis) 		PF03401
(TctC) 		5 VAL A 193
GLY A 107
ILE A 157
LEU A 130
ASP A 179
 None
 1.47A 6c2mC-2f5xA:
undetectable		 6c2mC-2f5xA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r16 NEUREXIN-1-ALPHA

(Bos taurus) 		PF02210
(Laminin_G_2) 		5 PHE A 753
VAL A 819
ILE A 854
ARG A 820
ASP A 748
 None
 1.45A 6c2mC-2r16A:
undetectable		 6c2mC-2r16A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rin PUTATIVE GLYCINE
BETAINE-BINDING ABC
TRANSPORTER PROTEIN

(Sinorhizobium
meliloti) 		PF04069
(OpuAC) 		5 PHE A  86
HIS A 236
GLY A  88
ILE A  56
ASP A 251
 None
 1.38A 6c2mC-2rinA:
undetectable		 6c2mC-2rinA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vlt THIOREDOXIN H
ISOFORM 2.

(Hordeum vulgare) 		PF00085
(Thioredoxin) 		5 PHE A  63
VAL A 115
HIS A 118
ILE A  15
ASP A  40
 None
 1.47A 6c2mC-2vltA:
undetectable		 6c2mC-2vltA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w48 SORBITOL OPERON
REGULATOR

(Klebsiella
pneumoniae) 		PF04198
(Sugar-bind)
PF13936
(HTH_38) 		5 VAL A 137
GLY A 110
ILE A 279
LEU A 209
ASP A 104
 None
 1.28A 6c2mC-2w48A:
undetectable		 6c2mC-2w48A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyh ALPHA-MANNOSIDASE

(Streptococcus
pyogenes) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		5 HIS A 349
ILE A  83
LEU A  51
ARG A  16
ASP A  60
 None
 0.97A 6c2mC-2wyhA:
undetectable		 6c2mC-2wyhA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I

(Legionella
pneumophila) 		PF01150
(GDA1_CD39) 		5 VAL A 182
GLY A 183
ILE A 386
LEU A 390
ASP A 172
 None
 1.37A 6c2mC-3aarA:
undetectable		 6c2mC-3aarA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c10 HISTONE DEACETYLASE
7A

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		5 VAL A 815
HIS A 814
GLY A 770
ILE A 727
ASP A 707
 None
None
None
None
ZN  A 101 (-2.1A)
 1.32A 6c2mC-3c10A:
undetectable		 6c2mC-3c10A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chv PROKARYOTIC DOMAIN
OF UNKNOWN FUNCTION
(DUF849) WITH A TIM
BARREL FOLD

(Ruegeria
pomeroyi) 		PF05853
(BKACE) 		5 GLY A 209
ILE A 154
LEU A 151
ARG A 186
ASP A 190
 None
 1.33A 6c2mC-3chvA:
undetectable		 6c2mC-3chvA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eq1 PORPHOBILINOGEN
DEAMINASE

(Homo sapiens) 		PF01379
(Porphobil_deam)
PF03900
(Porphobil_deamC) 		5 VAL A 267
HIS A 268
ILE A 350
LEU A 351
ARG A 149
 None
SO4  A 363 (-4.1A)
None
None
DPM  A 400 (-3.6A)
 1.33A 6c2mC-3eq1A:
undetectable		 6c2mC-3eq1A:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fa5 PROTEIN OF UNKNOWN
FUNCTION (DUF849)

(Paracoccus
denitrificans) 		PF05853
(BKACE) 		5 GLY A 177
ILE A 154
LEU A 151
ARG A 186
ASP A 190
 None
 1.18A 6c2mC-3fa5A:
undetectable		 6c2mC-3fa5A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fao NON-STRUCTURAL
PROTEIN

(Porcine
reproductive
and respiratory
syndrome virus) 		PF05579
(Peptidase_S32) 		5 VAL A 103
GLY A 105
LEU A 159
LYS A 158
ARG A  90
 None
 0.96A 6c2mC-3faoA:
8.6		 6c2mC-3faoA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		5 VAL A 234
HIS A 391
GLY A 394
ILE A 271
ASP A 186
 None
 1.32A 6c2mC-3gcwA:
undetectable		 6c2mC-3gcwA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE
FAD-SUBUNIT
NICOTINATE
DEHYDROGENASE SMALL
FES SUBUNIT

(Eubacterium
barkeri;
Eubacterium
barkeri) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C)
PF00111
(Fer2)
PF01799
(Fer2_2) 		5 VAL C  37
GLY C  33
ILE D   4
ARG D  24
ASP D  27
 None
FAD  C 900 (-3.3A)
None
None
None
 1.34A 6c2mC-3hrdC:
undetectable		 6c2mC-3hrdC:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE
FAD-SUBUNIT
NICOTINATE
DEHYDROGENASE SMALL
FES SUBUNIT

(Eubacterium
barkeri;
Eubacterium
barkeri) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C)
PF00111
(Fer2)
PF01799
(Fer2_2) 		5 VAL C  37
GLY C  33
ILE D   6
ARG D  24
ASP D  27
 None
FAD  C 900 (-3.3A)
None
None
None
 0.93A 6c2mC-3hrdC:
undetectable		 6c2mC-3hrdC:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i8a DIHYDROFOLATE
REDUCTASE

(Staphylococcus
aureus) 		PF00186
(DHFR_1) 		5 VAL X  89
HIS X  38
LEU X  62
ARG X  58
ASP X  74
 None
None
NDP  X 207 (-4.0A)
None
None
 1.36A 6c2mC-3i8aX:
undetectable		 6c2mC-3i8aX:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ijl MUCONATE
CYCLOISOMERASE

(Bacteroides
thetaiotaomicron) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 290
ILE A 250
LEU A 271
ARG A 321
ASP A 345
 None
 1.31A 6c2mC-3ijlA:
undetectable		 6c2mC-3ijlA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lyr TRANSCRIPTION FACTOR
COE1

(Homo sapiens) 		PF16422
(COE1_DBD) 		5 PHE A 190
VAL A 128
ILE A 159
LEU A 155
ARG A 129
 None
 1.18A 6c2mC-3lyrA:
undetectable		 6c2mC-3lyrA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1r FORMIMIDOYLGLUTAMASE

(Bacillus
subtilis) 		PF00491
(Arginase) 		5 VAL A 206
HIS A 204
GLY A 180
ILE A 239
ASP A 150
 None
None
None
None
CA  A 323 ( 2.7A)
 1.35A 6c2mC-3m1rA:
undetectable		 6c2mC-3m1rA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mqg LIPOPOLYSACCHARIDES
BIOSYNTHESIS
ACETYLTRANSFERASE

(Bordetella
petrii) 		PF00132
(Hexapep) 		5 HIS A  19
GLY A  17
LEU A  70
ARG A  55
ASP A  73
 None
 1.49A 6c2mC-3mqgA:
undetectable		 6c2mC-3mqgA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oq3 IFN-ALPHA/BETA
BINDING PROTEIN C12R

(Ectromelia
virus) 		PF00047
(ig)
PF13895
(Ig_2) 		5 VAL B  85
GLY B  88
ILE B 119
LEU B 105
ARG B  84
 None
 1.34A 6c2mC-3oq3B:
undetectable		 6c2mC-3oq3B:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ouu BIOTIN CARBOXYLASE

(Campylobacter
jejuni) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 PHE A  80
GLY A  82
ILE A  50
ARG A  11
ASP A  37
 None
 1.08A 6c2mC-3ouuA:
undetectable		 6c2mC-3ouuA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz2 DIGERANYLGERANYLGLYC
EROPHOSPHOLIPID
REDUCTASE

(Thermoplasma
acidophilum) 		PF01494
(FAD_binding_3) 		5 VAL A 134
GLY A 277
ILE A  32
ARG A 149
ASP A 147
 None
 1.35A 6c2mC-3oz2A:
undetectable		 6c2mC-3oz2A:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p9t REPRESSOR

(Stenotrophomonas
maltophilia) 		PF00440
(TetR_N)
PF08361
(TetR_C_2) 		5 VAL A 206
GLY A 205
ILE A  94
LEU A 194
ASP A  88
 None
 1.40A 6c2mC-3p9tA:
undetectable		 6c2mC-3p9tA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rtx MRNA-CAPPING ENZYME

(Mus musculus) 		PF01331
(mRNA_cap_enzyme)
PF03919
(mRNA_cap_C) 		5 PHE A 320
ILE A 304
LEU A 303
ARG A 299
ASP A 343
 None
None
None
GUN  A   1 (-3.8A)
GUN  A   1 (-3.3A)
 1.08A 6c2mC-3rtxA:
undetectable		 6c2mC-3rtxA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s3f TYROSINE-PROTEIN
PHOSPHATASE 10D

(Drosophila
melanogaster) 		PF00102
(Y_phosphatase) 		5 VAL A 117
HIS A 241
GLY A 245
ILE A 294
ASP A 256
 None
 1.34A 6c2mC-3s3fA:
undetectable		 6c2mC-3s3fA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uqz DNA PROCESSING
PROTEIN DPRA

(Streptococcus
pneumoniae) 		PF02481
(DNA_processg_A) 		5 HIS A 204
GLY A 168
LEU A 180
LYS A 178
ASP A 147
 None
None
None
SO4  A 302 (-4.0A)
None
 1.36A 6c2mC-3uqzA:
undetectable		 6c2mC-3uqzA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vhj BFPC

(Escherichia
coli) 		no annotation 5 PHE A  80
VAL A 101
HIS A 108
GLY A 105
LEU A 155
 None
 1.18A 6c2mC-3vhjA:
undetectable		 6c2mC-3vhjA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zqj UVRABC SYSTEM
PROTEIN A

(Mycobacterium
tuberculosis) 		PF00005
(ABC_tran) 		5 VAL A 834
GLY A 832
ILE A 724
ARG A 835
ASP A 803
 None
 1.37A 6c2mC-3zqjA:
undetectable		 6c2mC-3zqjA:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
43ca PROTEIN
(IMMUNOGLOBULIN
(HEAVY CHAIN))

(Mus musculus) 		PF07686
(V-set) 		5 VAL B 109
GLY B   8
ILE B  69
LEU B  67
LYS B  81
 None
 1.31A 6c2mC-43caB:
undetectable		 6c2mC-43caB:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arc LEUCINE--TRNA LIGASE

(Escherichia
coli) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		5 VAL A 835
GLY A 830
ILE A 848
LEU A 854
ARG A 811
 None
None
C  B  56 ( 3.7A)
G  B  19 ( 4.1A)
C  B  47 ( 2.9A)
 1.20A 6c2mC-4arcA:
undetectable		 6c2mC-4arcA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4doe 1,4-BETA-GLUCANASE

(Caldicellulosiruptor
bescii) 		PF00759
(Glyco_hydro_9) 		5 VAL A 284
HIS A 285
GLY A 287
LEU A  95
ASP A 447
 None
None
None
None
CT3  A 504 ( 4.5A)
 1.23A 6c2mC-4doeA:
undetectable		 6c2mC-4doeA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A 454
ILE A 432
LYS A 509
ARG A 498
ASP A 494
 0SB  A 701 (-3.5A)
None
None
None
None
 1.34A 6c2mC-4f4pA:
undetectable		 6c2mC-4f4pA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gaa MGC78867 PROTEIN

(Xenopus laevis) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		5 PHE A 585
VAL A 600
ILE A 548
ARG A 569
ASP A 570
 None
 1.36A 6c2mC-4gaaA:
undetectable		 6c2mC-4gaaA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ida RIPENING-INDUCED
PROTEIN

(Fragaria vesca) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		5 VAL A 175
HIS A 178
GLY A 176
ILE A 262
LEU A 263
 None
 1.23A 6c2mC-4idaA:
undetectable		 6c2mC-4idaA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l6u PUTATIVE
UNCHARACTERIZED
PROTEIN

(Archaeoglobus
fulgidus) 		PF03787
(RAMPs) 		5 VAL A 292
HIS A 291
GLY A 217
ILE A 313
ARG A 293
 None
 1.22A 6c2mC-4l6uA:
undetectable		 6c2mC-4l6uA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m6r METHYLTHIORIBULOSE-1
-PHOSPHATE
DEHYDRATASE

(Homo sapiens) 		PF00596
(Aldolase_II) 		5 VAL A 197
HIS A 117
GLY A 196
ILE A 220
LEU A 217
 None
ZN  A 301 (-3.3A)
None
None
None
 1.35A 6c2mC-4m6rA:
undetectable		 6c2mC-4m6rA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mm0 P450-LIKE
MONOOXYGENASE

(Streptomyces
griseoviridis) 		PF00067
(p450) 		5 VAL A 193
GLY A 191
ILE A 229
LEU A 230
ASP A 222
 None
 1.41A 6c2mC-4mm0A:
undetectable		 6c2mC-4mm0A:
12.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nwk HCV NS3 1A PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		7 PHE A  43
VAL A  55
GLY A  58
ILE A 132
LEU A 135
ARG A 155
ASP A 168
 2R8  A 301 (-4.6A)
None
2R8  A 301 (-3.5A)
2R8  A 301 (-4.3A)
2R8  A 301 (-4.4A)
2R8  A 301 (-3.6A)
2R8  A 301 ( 4.5A)
 0.41A 6c2mC-4nwkA:
35.5		 6c2mC-4nwkA:
95.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		5 VAL B 234
HIS B 391
GLY B 394
ILE B 271
ASP B 186
 None
 1.27A 6c2mC-4ov6B:
undetectable		 6c2mC-4ov6B:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi7 CELLOBIOSE
DEHYDROGENASE

(Neurospora
crassa) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C)
PF16010
(CDH-cyt) 		5 GLY A 348
ILE A 763
LEU A 764
LYS A 762
ASP A 246
 None
 1.24A 6c2mC-4qi7A:
undetectable		 6c2mC-4qi7A:
7.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rg8 EXONUCLEASE I

(Methylocaldum
szegediense) 		PF00929
(RNase_T)
PF08411
(Exonuc_X-T_C) 		5 VAL A 290
GLY A 289
ILE A 268
LEU A 267
ASP A 274
 None
 1.40A 6c2mC-4rg8A:
undetectable		 6c2mC-4rg8A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rjk ACETOLACTATE
SYNTHASE

(Bacillus
subtilis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 VAL A 428
GLY A 427
ILE A 135
LEU A  96
ASP A 104
 None
 1.47A 6c2mC-4rjkA:
undetectable		 6c2mC-4rjkA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rws C-X-C CHEMOKINE
RECEPTOR TYPE
4/ENDOLYSIN CHIMERIC
PROTEIN

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme)
PF12109
(CXCR4_N) 		5 VAL A 156
GLY A 159
ILE A 215
LEU A 127
ASP A 133
 None
 1.30A 6c2mC-4rwsA:
undetectable		 6c2mC-4rwsA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v20 CELLOBIOHYDROLASE

(Aspergillus
fumigatus) 		PF00840
(Glyco_hydro_7) 		5 VAL A  41
HIS A  42
ILE A 183
LEU A 180
ARG A  39
 None
ACT  A1444 (-4.6A)
None
None
None
 1.42A 6c2mC-4v20A:
undetectable		 6c2mC-4v20A:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yj5 PYRUVATE KINASE PKM

(Homo sapiens) 		PF00224
(PK)
PF02887
(PK_C) 		5 VAL A  71
ILE A 267
LYS A 266
ARG A  73
ASP A 113
 None
None
None
PYR  A 601 ( 4.7A)
MG  A 602 (-3.4A)
 1.27A 6c2mC-4yj5A:
undetectable		 6c2mC-4yj5A:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yt9 PEPTIDYLARGININE
DEIMINASE

(Porphyromonas
gingivalis) 		PF04371
(PAD_porph) 		5 VAL A 193
HIS A 223
ILE A 300
LEU A 244
ASP A 238
 None
None
None
None
4GJ  A 351 ( 3.4A)
 1.42A 6c2mC-4yt9A:
undetectable		 6c2mC-4yt9A:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxo GLYCOSYL HYDROLASE
FAMILY 26

(Bacteroides
ovatus) 		PF02156
(Glyco_hydro_26) 		5 VAL A 253
ILE A 312
LEU A 274
ARG A 184
ASP A 257
 None
 1.48A 6c2mC-4zxoA:
undetectable		 6c2mC-4zxoA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT

(Azospira oryzae) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 PHE A 360
VAL A 372
ILE A 316
ARG A 283
ASP A 294
 None
 1.15A 6c2mC-5chcA:
undetectable		 6c2mC-5chcA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		5 VAL A 100
ILE A 263
LEU A 261
ARG A 109
ASP A 377
 None
 1.43A 6c2mC-5dkxA:
undetectable		 6c2mC-5dkxA:
6.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eqq NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		8 PHE A1043
VAL A1055
GLY A1058
ILE A1132
LEU A1135
LYS A1136
ARG A1155
ASP A1168
 5RS  A1203 (-4.3A)
None
5RS  A1203 ( 2.9A)
5RS  A1203 ( 4.1A)
5RS  A1203 (-4.2A)
5RS  A1203 (-4.8A)
5RS  A1203 (-4.8A)
5RS  A1203 ( 4.0A)
 0.52A 6c2mC-5eqqA:
35.5		 6c2mC-5eqqA:
98.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fo1 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF

(Corynebacterium
ammoniagenes) 		PF01687
(Flavokinase)
PF06574
(FAD_syn) 		5 PHE A  84
VAL A  27
HIS A  28
ILE A  50
ARG A  77
 None
None
PPV  A1339 (-3.7A)
None
None
 1.33A 6c2mC-5fo1A:
undetectable		 6c2mC-5fo1A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqt NITRILE-SPECIFIER
PROTEIN 1

(Arabidopsis
thaliana) 		PF01344
(Kelch_1)
PF01419
(Jacalin)
PF13415
(Kelch_3) 		5 VAL A 363
GLY A 362
LEU A 149
ARG A 416
ASP A 418
 None
 1.46A 6c2mC-5gqtA:
undetectable		 6c2mC-5gqtA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqt NITRILE-SPECIFIER
PROTEIN 1

(Arabidopsis
thaliana) 		PF01344
(Kelch_1)
PF01419
(Jacalin)
PF13415
(Kelch_3) 		5 VAL A 363
GLY A 362
LYS A 148
ARG A 416
ASP A 418
 None
 1.37A 6c2mC-5gqtA:
undetectable		 6c2mC-5gqtA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hbt FAB35, HEAVY CHAIN

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL D 116
GLY D   8
ILE D  69
LEU D  67
LYS D  81
 None
 1.29A 6c2mC-5hbtD:
undetectable		 6c2mC-5hbtD:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hn4 HOMOISOCITRATE
DEHYDROGENASE

(Thermococcus
kodakarensis) 		PF00180
(Iso_dh) 		5 VAL A 293
GLY A 291
ILE A  97
ARG A 102
ASP A 100
 None
 1.45A 6c2mC-5hn4A:
0.0		 6c2mC-5hn4A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1c WD REPEAT-CONTAINING
PROTEIN 20

(Homo sapiens) 		PF00400
(WD40) 		5 VAL C 152
GLY C 125
ILE C 130
LEU C 129
ASP C 105
 None
 1.50A 6c2mC-5k1cC:
undetectable		 6c2mC-5k1cC:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mhf MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE

(Mus musculus) 		no annotation 5 HIS A 361
GLY A 156
LEU A 395
ARG A 153
ASP A 460
 None
 1.33A 6c2mC-5mhfA:
undetectable		 6c2mC-5mhfA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncr TYROSINE PHOSPHATASE

(Orf virus) 		PF00782
(DSPc) 		5 VAL A 127
HIS A 129
GLY A 125
LEU A 148
ARG A 131
 None
 1.46A 6c2mC-5ncrA:
undetectable		 6c2mC-5ncrA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncs SERPIN

(Tannerella
forsythia) 		PF00079
(Serpin) 		5 PHE A 387
VAL A 386
GLY A 401
ILE A 287
ASP A 243
 None
 1.44A 6c2mC-5ncsA:
undetectable		 6c2mC-5ncsA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ods CLATHRIN HEAVY CHAIN
1

(Mus musculus) 		no annotation 5 VAL A 478
GLY A 464
LEU A 427
ARG A 481
ASP A 455
 None
 1.37A 6c2mC-5odsA:
undetectable		 6c2mC-5odsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5suo EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF12010
(DUF3502) 		5 VAL A 353
HIS A 382
GLY A 385
ILE A 338
LEU A 341
 None
 1.46A 6c2mC-5suoA:
undetectable		 6c2mC-5suoA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy5 ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR

(Mus musculus) 		PF00010
(HLH)
PF00989
(PAS)
PF14598
(PAS_11) 		5 VAL A 304
HIS A 302
LEU A 209
ARG A 266
ASP A 217
 None
 1.37A 6c2mC-5sy5A:
undetectable		 6c2mC-5sy5A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum) 		PF01547
(SBP_bac_1) 		5 VAL A  40
GLY A  67
LEU A 333
ARG A 325
ASP A  95
 None
 1.49A 6c2mC-5u2pA:
undetectable		 6c2mC-5u2pA:
9.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wdx JFH-1 NS3

(Hepacivirus C) 		no annotation 6 PHE A  43
VAL A  55
GLY A  58
ILE A 132
LEU A 135
ASP A 168
 None
 0.49A 6c2mC-5wdxA:
27.4		 6c2mC-5wdxA:
37.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wdx JFH-1 NS3

(Hepacivirus C) 		no annotation 5 PHE A  43
VAL A  55
LEU A 135
ARG A 155
ASP A 168
 None
 1.42A 6c2mC-5wdxA:
27.4		 6c2mC-5wdxA:
37.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xau LAMININ SUBUNIT
ALPHA-5

(Homo sapiens) 		PF02210
(Laminin_G_2)
PF06009
(Laminin_II) 		5 VAL A3121
GLY A3122
LEU A2905
ARG A3275
ASP A2834
 None
 1.19A 6c2mC-5xauA:
undetectable		 6c2mC-5xauA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
ES4

(Toxoplasma
gondii) 		PF00467
(KOW)
PF00900
(Ribosomal_S4e)
PF01479
(S4)
PF08071
(RS4NT)
PF16121
(40S_S4_C) 		5 VAL E 227
GLY E 229
ILE E 169
LEU E 162
ARG E 125
 None
 1.50A 6c2mC-5xxuE:
undetectable		 6c2mC-5xxuE:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yl7 PSEUDOALTEROMONAS
ARCTICA PAMC 21717

(Pseudoalteromonas
arctica) 		no annotation 5 VAL A 252
HIS A 430
GLY A 433
ILE A 291
ASP A 185
 None
 1.08A 6c2mC-5yl7A:
undetectable		 6c2mC-5yl7A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6blg DTDP-4-AMINO-4,6-DID
EOXYGALACTOSE
TRANSAMINASE

(Klebsiella
pneumoniae) 		no annotation 5 VAL A 131
HIS A 127
GLY A 130
ILE A 295
LEU A 279
 None
 1.46A 6c2mC-6blgA:
undetectable		 6c2mC-6blgA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d0s TBC1 DOMAIN FAMILY
MEMBER 22B

(Homo sapiens) 		no annotation 5 PHE A 319
VAL A 320
LEU A 358
ARG A 216
ASP A 428
 None
None
None
UNX  A 611 ( 4.2A)
None
 1.46A 6c2mC-6d0sA:
undetectable		 6c2mC-6d0sA:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9m SERINE PROTEASE

(Planococcus
plakortidis) 		no annotation 5 VAL A 118
GLY A 133
ILE A  63
LEU A 113
ASP A  82
 None
 1.44A 6c2mC-6f9mA:
undetectable		 6c2mC-6f9mA:
26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus) 		no annotation 5 PHE A2453
GLY A2442
LEU A2539
ARG A2359
ASP A2353
 None
 1.21A 6c2mC-6fb3A:
undetectable		 6c2mC-6fb3A:
20.00