SIMILAR PATTERNS OF AMINO ACIDS FOR 6C2M_C_SUEC1203

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a5i PLASMINOGEN
ACTIVATOR

(Desmodus
rotundus) 		PF00089
(Trypsin) 		5 HIS A  57
ASP A 102
GLY A 193
SER A 195
VAL A 217
 0GJ  A 245 (-2.7A)
None
0GJ  A 245 (-3.7A)
0GJ  A 245 (-1.4A)
0GJ  A 245 ( 4.9A)
 0.90A 6c2mC-1a5iA:
4.4		 6c2mC-1a5iA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a8q BROMOPEROXIDASE A1

(Kitasatospora
aureofaciens) 		PF00561
(Abhydrolase_1) 		5 HIS A 252
ASP A 223
GLY A  27
SER A  94
ALA A 255
 None
 0.98A 6c2mC-1a8qA:
undetectable		 6c2mC-1a8qA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1aok VIPOXIN COMPLEX

(Vipera
ammodytes) 		PF00068
(Phospholip_A2_1) 		5 ARG B 100
PHE B   5
ALA B 103
ALA B 102
VAL B 101
 None
ACT  B 134 (-4.6A)
None
ACT  B 134 ( 4.7A)
None
 1.04A 6c2mC-1aokB:
undetectable		 6c2mC-1aokB:
19.69
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)

(Hepacivirus C) 		PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD) 		10 GLN A  41
HIS A  57
VAL A  78
ASP A  81
ARG A 123
GLY A 137
PHE A 154
ALA A 156
ALA A 157
VAL A 158
 None
 0.57A 6c2mC-1cu1A:
34.7		 6c2mC-1cu1A:
47.97
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)

(Hepacivirus C) 		PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD) 		10 GLN A  41
HIS A  57
VAL A  78
ASP A  81
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
VAL A 158
 None
 0.62A 6c2mC-1cu1A:
34.7		 6c2mC-1cu1A:
47.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dle COMPLEMENT FACTOR B

(Homo sapiens) 		PF00089
(Trypsin) 		5 HIS A  57
ASP A 102
GLY A 193
SER A 195
VAL A 217
 None
 0.82A 6c2mC-1dleA:
4.1		 6c2mC-1dleA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ep5 CAPSID PROTEIN C

(Venezuelan
equine
encephalitis
virus) 		no annotation 5 HIS B 152
ASP B 174
GLY B 224
SER B 226
VAL B 245
 None
 0.70A 6c2mC-1ep5B:
11.0		 6c2mC-1ep5B:
19.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1evq SERINE HYDROLASE

(Alicyclobacillus
acidocaldarius) 		PF07859
(Abhydrolase_3) 		5 HIS A 282
ASP A 252
GLY A  82
SER A 155
ALA A 285
 EPE  A 455 (-4.0A)
None
EPE  A 455 (-3.5A)
EPE  A 455 (-1.4A)
None
 1.03A 6c2mC-1evqA:
undetectable		 6c2mC-1evqA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1exf EXFOLIATVE TOXIN A

(Staphylococcus
aureus) 		PF13365
(Trypsin_2) 		5 HIS A  57
ASP A 102
ARG A 182
GLY A 193
SER A 195
 None
 0.82A 6c2mC-1exfA:
10.5		 6c2mC-1exfA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fiw BETA-ACROSIN HEAVY
CHAIN

(Ovis aries) 		PF00089
(Trypsin) 		5 HIS A  57
ASP A 102
GLY A 193
SER A 195
VAL A 217
 None
None
None
PBZ  A 305 (-2.9A)
None
 0.95A 6c2mC-1fiwA:
9.7		 6c2mC-1fiwA:
16.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fiz BETA-ACROSIN HEAVY
CHAIN

(Sus scrofa) 		PF00089
(Trypsin) 		5 HIS A  57
ASP A 102
GLY A 193
SER A 195
VAL A 217
 None
None
None
PBZ  A 308 (-3.2A)
None
 0.88A 6c2mC-1fizA:
9.5		 6c2mC-1fizA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jkm BREFELDIN A ESTERASE

(Bacillus
subtilis) 		PF07859
(Abhydrolase_3) 		5 HIS A 338
ASP A 308
ARG A 331
GLY A 126
SER A 202
 None
 0.83A 6c2mC-1jkmA:
undetectable		 6c2mC-1jkmA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kig FACTOR XA

(Bos taurus) 		PF00089
(Trypsin) 		5 GLN H  61
HIS H  57
ASP H 102
GLY H 193
SER H 195
 None
 0.87A 6c2mC-1kigH:
9.5		 6c2mC-1kigH:
20.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ks6 TRANSFORMING GROWTH
FACTOR BETA TYPE II
RECEPTOR

(Gallus gallus) 		PF08917
(ecTbetaR2) 		5 ASP A  58
GLY A  95
ALA A  40
ALA A  41
VAL A  42
 None
 1.02A 6c2mC-1ks6A:
undetectable		 6c2mC-1ks6A:
14.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m9u EARTHWORM
FIBRINOLYTIC ENZYME

(Eisenia fetida) 		PF00089
(Trypsin) 		5 HIS A  57
ASP A 102
GLY A 193
SER A 195
VAL A 217
 None
 0.87A 6c2mC-1m9uA:
10.8		 6c2mC-1m9uA:
15.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ns3 NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		8 GLN A  41
HIS A  57
VAL A  78
ASP A  81
ARG A 123
GLY A 137
ALA A 157
VAL A 158
 None
 0.87A 6c2mC-1ns3A:
30.6		 6c2mC-1ns3A:
39.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ns3 NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		6 GLN A  41
HIS A  57
VAL A  78
ASP A  81
GLY A 137
SER A 139
 None
 1.01A 6c2mC-1ns3A:
30.6		 6c2mC-1ns3A:
39.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ns3 NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		9 HIS A  57
VAL A  78
ASP A  81
ARG A 123
GLY A 137
PHE A 154
ALA A 156
ALA A 157
VAL A 158
 None
 0.66A 6c2mC-1ns3A:
30.6		 6c2mC-1ns3A:
39.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p3c GLUTAMYL-ENDOPEPTIDA
SE

(Bacillus
intermedius) 		PF00089
(Trypsin) 		5 HIS A  47
ASP A  97
GLY A 169
SER A 171
ALA A 188
 None
 0.70A 6c2mC-1p3cA:
10.5		 6c2mC-1p3cA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rtk COMPLEMENT FACTOR B

(Homo sapiens) 		PF00089
(Trypsin)
PF00092
(VWA) 		5 HIS A 501
ASP A 551
GLY A 672
SER A 674
VAL A 696
 GBS  A 750 (-4.1A)
None
None
GBS  A 750 (-1.3A)
None
 0.87A 6c2mC-1rtkA:
2.6		 6c2mC-1rtkA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ub7 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
SYNTHASE

(Thermus
thermophilus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 VAL A 219
GLY A 112
ALA A 314
ALA A 315
VAL A 316
 None
CSO  A 110 ( 4.2A)
None
None
None
 0.93A 6c2mC-1ub7A:
undetectable		 6c2mC-1ub7A:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vax URIC ACID OXIDASE

(Arthrobacter
globiformis) 		PF01014
(Uricase) 		5 GLN A  40
VAL A  25
ALA A 135
ALA A 148
VAL A 147
 None
 1.05A 6c2mC-1vaxA:
undetectable		 6c2mC-1vaxA:
16.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vip PHOSPHOLIPASE A2

(Daboia russelii) 		PF00068
(Phospholip_A2_1) 		5 ARG A 100
PHE A   5
ALA A 103
ALA A 102
VAL A 101
 None
 1.07A 6c2mC-1vipA:
undetectable		 6c2mC-1vipA:
18.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wcz GLUTAMYL
ENDOPEPTIDASE

(Staphylococcus
aureus) 		PF13365
(Trypsin_2) 		5 HIS A  51
ASP A  93
GLY A 167
SER A 169
VAL A 188
 None
 0.87A 6c2mC-1wczA:
11.8		 6c2mC-1wczA:
18.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y8t HYPOTHETICAL PROTEIN
RV0983

(Mycobacterium
tuberculosis) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 HIS A  49
ASP A  88
GLY A 167
SER A 169
ALA A 186
 None
 0.79A 6c2mC-1y8tA:
12.6		 6c2mC-1y8tA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo sapiens) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		5 VAL A 352
ASP A 351
GLY A 116
ALA A 109
ALA A 108
 None
 1.00A 6c2mC-2c11A:
undetectable		 6c2mC-2c11A:
8.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fpg SUCCINYL-COA LIGASE
[GDP-FORMING]
BETA-CHAIN,
MITOCHONDRIAL

(Sus scrofa) 		PF00549
(Ligase_CoA)
PF08442
(ATP-grasp_2) 		6 GLN B  92
VAL B 205
ASP B 220
GLY B  57
ALA B  47
VAL B 103
 None
None
K  B 396 ( 3.6A)
None
None
None
 1.30A 6c2mC-2fpgB:
undetectable		 6c2mC-2fpgB:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pnc COPPER AMINE
OXIDASE, LIVER
ISOZYME

(Bos taurus) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		5 VAL A 351
ASP A 350
GLY A 115
ALA A 108
ALA A 107
 None
 0.95A 6c2mC-2pncA:
undetectable		 6c2mC-2pncA:
8.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pro ALPHA-LYTIC PROTEASE

(Lysobacter
enzymogenes) 		PF02983
(Pro_Al_protease) 		6 VAL A 128
ARG A  82
GLY A  45
ALA A  66
ALA A  65
VAL A  64
 None
 1.38A 6c2mC-2proA:
undetectable		 6c2mC-2proA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qog PHOSPHOLIPASE A2 CB2

(Crotalus
durissus) 		PF00068
(Phospholip_A2_1) 		5 ARG A 100
PHE A   5
ALA A 103
ALA A 102
VAL A 101
 None
 1.05A 6c2mC-2qogA:
undetectable		 6c2mC-2qogA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vid SERINE PROTEASE SPLB

(Staphylococcus
aureus) 		PF00089
(Trypsin) 		5 HIS A  39
ASP A  77
GLY A 155
SER A 157
ALA A 174
 None
 0.71A 6c2mC-2vidA:
12.1		 6c2mC-2vidA:
18.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2whx SERINE
PROTEASE/NTPASE/HELI
CASE NS3

(Dengue virus) 		PF00949
(Peptidase_S7)
PF07652
(Flavi_DEAD) 		5 HIS A  51
VAL A  72
ASP A  75
GLY A 133
SER A 135
 None
 0.86A 6c2mC-2whxA:
11.2		 6c2mC-2whxA:
7.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wv0 HTH-TYPE
TRANSCRIPTIONAL
REPRESSOR YVOA

(Bacillus
subtilis) 		PF00392
(GntR)
PF07702
(UTRA) 		5 GLN A 163
GLY A 101
ALA A 143
VAL A 227
SER A 226
 None
 0.92A 6c2mC-2wv0A:
undetectable		 6c2mC-2wv0A:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xwb COMPLEMENT FACTOR B

(Homo sapiens) 		PF00084
(Sushi)
PF00089
(Trypsin)
PF00092
(VWA) 		5 HIS F 501
ASP F 551
GLY F 672
SER F 674
VAL F 696
 None
 0.72A 6c2mC-2xwbF:
4.3		 6c2mC-2xwbF:
7.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2z TK-SUBTILISIN
PRECURSOR

(Thermococcus
kodakarensis) 		PF00082
(Peptidase_S8) 		5 GLY A 237
SER A 271
ALA A 261
ALA A 260
VAL A 259
 None
 1.06A 6c2mC-2z2zA:
undetectable		 6c2mC-2z2zA:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3act CELLOBIOSE
PHOSPHORYLASE

(Cellulomonas
gilvus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		5 GLY A 529
ALA A 523
ALA A 522
VAL A 519
SER A 518
 None
 1.06A 6c2mC-3actA:
undetectable		 6c2mC-3actA:
7.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ak5 HEMOGLOBIN-BINDING
PROTEASE HBP

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		5 HIS A 125
ASP A 153
GLY A 257
SER A 259
ALA A 281
 None
 0.71A 6c2mC-3ak5A:
6.8		 6c2mC-3ak5A:
6.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aw9 NAD-DEPENDENT
EPIMERASE/DEHYDRATAS
E

(Pyrobaculum
calidifontis) 		PF01370
(Epimerase) 		5 VAL A  92
ALA A 136
ALA A 135
VAL A 132
SER A 131
 None
 1.03A 6c2mC-3aw9A:
undetectable		 6c2mC-3aw9A:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cp7 ALKALINE SERINE
PROTEASE AL20

(Nesterenkonia
aethiopica) 		PF13365
(Trypsin_2) 		5 HIS A  41
ASP A  91
GLY A 167
SER A 169
VAL A 197
 FMT  A 219 (-3.9A)
None
FMT  A 219 (-3.6A)
FMT  A 219 (-2.6A)
None
 1.05A 6c2mC-3cp7A:
6.1		 6c2mC-3cp7A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3enq RIBOSE-5-PHOSPHATE
ISOMERASE A

(Vibrio
vulnificus) 		PF06026
(Rib_5-P_isom_A) 		5 GLY A  40
SER A  43
ALA A  49
VAL A  50
SER A  51
 None
 0.97A 6c2mC-3enqA:
undetectable		 6c2mC-3enqA:
19.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7n LIPASE

(Penicillium
expansum) 		PF01764
(Lipase_3) 		6 HIS A 241
VAL A 186
ASP A 188
PHE A 162
ALA A 161
ALA A 136
 SO4  A 259 ( 4.6A)
None
None
None
None
None
 1.18A 6c2mC-3g7nA:
undetectable		 6c2mC-3g7nA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		6 GLN A 382
HIS A 226
ASP A 186
GLY A 384
SER A 386
ALA A 290
 None
 1.20A 6c2mC-3gcwA:
undetectable		 6c2mC-3gcwA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hea ARYLESTERASE

(Pseudomonas
fluorescens) 		PF00561
(Abhydrolase_1) 		5 HIS A 251
ASP A 222
GLY A  27
SER A  94
ALA A 254
 EEE  A 300 (-4.3A)
None
EEE  A 300 (-3.4A)
EEE  A 300 (-1.4A)
None
 0.99A 6c2mC-3heaA:
undetectable		 6c2mC-3heaA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jv7 ADH-A

(Rhodococcus
ruber) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 ASP A 218
GLY A 170
ALA A 175
ALA A 242
VAL A 243
 None
 1.06A 6c2mC-3jv7A:
undetectable		 6c2mC-3jv7A:
14.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkw FUSION PROTEIN OF
NONSTRUCTURAL
PROTEIN 2B AND
NONSTRUCTURAL
PROTEIN 3

(Dengue virus) 		PF00949
(Peptidase_S7)
PF01002
(Flavi_NS2B) 		5 HIS A 101
VAL A 122
ASP A 125
GLY A 183
VAL A 212
 GOL  A 303 (-3.7A)
None
GOL  A 303 ( 4.7A)
None
None
 0.77A 6c2mC-3lkwA:
5.9		 6c2mC-3lkwA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5n RIBOFLAVIN UPTAKE
PROTEIN

(Staphylococcus
aureus) 		PF12822
(ECF_trnsprt) 		5 VAL A  49
ASP A  48
GLY A  84
ALA A  91
SER A 128
 None
None
RBF  A 190 (-3.1A)
RBF  A 190 (-3.4A)
None
 1.01A 6c2mC-3p5nA:
undetectable		 6c2mC-3p5nA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5n RIBOFLAVIN UPTAKE
PROTEIN

(Staphylococcus
aureus) 		PF12822
(ECF_trnsprt) 		5 VAL A  49
ASP A  48
GLY A  84
ALA A  91
VAL A 126
 None
None
RBF  A 190 (-3.1A)
RBF  A 190 (-3.4A)
None
 0.97A 6c2mC-3p5nA:
undetectable		 6c2mC-3p5nA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qo6 PROTEASE DO-LIKE 1,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 HIS A 173
ASP A 203
GLY A 280
SER A 282
ALA A 299
 None
 0.74A 6c2mC-3qo6A:
12.9		 6c2mC-3qo6A:
11.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3stj PROTEASE DEGQ

(Escherichia
coli) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 HIS A  82
ASP A 112
GLY A 185
SER A 187
ALA A 204
 None
 0.62A 6c2mC-3stjA:
13.2		 6c2mC-3stjA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1j SERINE PROTEASE NS3

(Dengue virus) 		PF00949
(Peptidase_S7) 		6 HIS B  51
VAL B  72
ASP B  75
GLY B 133
SER B 135
VAL B 155
 None
 1.35A 6c2mC-3u1jB:
12.6		 6c2mC-3u1jB:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u1j SERINE PROTEASE NS3

(Dengue virus) 		PF00949
(Peptidase_S7) 		6 HIS B  51
VAL B  72
ASP B  75
GLY B 133
SER B 135
VAL B 162
 None
 0.91A 6c2mC-3u1jB:
12.6		 6c2mC-3u1jB:
19.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ufa SERINE PROTEASE SPLA

(Staphylococcus
aureus) 		PF00089
(Trypsin) 		5 HIS A  39
ASP A  78
GLY A 152
SER A 154
ALA A 171
 VPF  A 201 (-3.8A)
None
VPF  A 201 (-3.3A)
VPF  A 201 (-1.7A)
VPF  A 201 (-4.9A)
 0.80A 6c2mC-3ufaA:
11.7		 6c2mC-3ufaA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3voo FATTY ACID
ALPHA-HYDROXYLASE

(Sphingomonas
paucimobilis) 		PF00067
(p450) 		5 ARG A 186
GLY A 199
ALA A 193
ALA A 233
VAL A 234
 None
 1.01A 6c2mC-3vooA:
undetectable		 6c2mC-3vooA:
11.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w15 PEROXISOMAL
TARGETING SIGNAL 2
RECEPTOR

(Saccharomyces
cerevisiae) 		PF00400
(WD40) 		5 GLN A  60
GLY A  81
ALA A  28
ALA A  27
VAL A  26
 None
 0.92A 6c2mC-3w15A:
undetectable		 6c2mC-3w15A:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w94 ENTEROPEPTIDASE-1

(Oryzias latipes) 		PF00089
(Trypsin) 		5 HIS A 836
ASP A 887
GLY A 977
SER A 979
VAL A1001
 None
 0.88A 6c2mC-3w94A:
10.5		 6c2mC-3w94A:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wau 4-O-BETA-D-MANNOSYL-
D-GLUCOSE
PHOSPHORYLASE

(Bacteroides
fragilis) 		PF04041
(Glyco_hydro_130) 		5 ASP A 131
GLY A  91
SER A  96
ALA A  99
VAL A 100
 M1P  A 404 (-2.9A)
None
None
None
None
 0.87A 6c2mC-3wauA:
undetectable		 6c2mC-3wauA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wj2 CARBOXYLESTERASE

(Ferroplasma
acidiphilum) 		PF07859
(Abhydrolase_3) 		5 HIS A 281
ASP A 251
GLY A  84
SER A 156
ALA A 284
 None
 1.08A 6c2mC-3wj2A:
undetectable		 6c2mC-3wj2A:
10.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpc RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBD

(Acinetobacter
baumannii) 		PF00383
(dCMP_cyt_deam_1)
PF01872
(RibD_C) 		5 ASP A 162
ARG A 322
ALA A 321
ALA A 168
SER A 169
 None
 1.02A 6c2mC-3zpcA:
undetectable		 6c2mC-3zpcA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c9m CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		5 GLY A  39
PHE A 267
ALA A 406
ALA A 405
VAL A 404
 None
None
None
None
GOL  A1419 (-3.5A)
 0.88A 6c2mC-4c9mA:
undetectable		 6c2mC-4c9mA:
10.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwd MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
C-TERMINAL DOMAIN
PROTEIN

(Paracoccus
denitrificans) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ARG A 240
PHE A 222
ALA A 207
VAL A 204
SER A 203
 None
 1.07A 6c2mC-4dwdA:
undetectable		 6c2mC-4dwdA:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dxy CYTOCHROME P450

(Novosphingobium
aromaticivorans) 		PF00067
(p450) 		5 GLY A  37
PHE A 265
ALA A 404
ALA A 403
VAL A 402
 None
 0.96A 6c2mC-4dxyA:
undetectable		 6c2mC-4dxyA:
11.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fln PROTEASE DO-LIKE 2,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 HIS A 159
VAL A 187
ASP A 190
GLY A 266
SER A 268
 None
 0.60A 6c2mC-4flnA:
5.8		 6c2mC-4flnA:
9.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iig BETA-GLUCOSIDASE 1

(Aspergillus
aculeatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 HIS A 549
VAL A 501
GLY A 575
SER A 578
ALA A 397
 None
 1.06A 6c2mC-4iigA:
undetectable		 6c2mC-4iigA:
7.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4inl SERINE PROTEASE SPLD

(Staphylococcus
aureus) 		PF13365
(Trypsin_2) 		5 HIS A  39
ASP A  78
GLY A 154
SER A 156
ALA A 173
 None
 0.72A 6c2mC-4inlA:
12.2		 6c2mC-4inlA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcn GLUTAMYL
ENDOPEPTIDASE

(Staphylococcus
epidermidis) 		PF13365
(Trypsin_2) 		5 HIS A 117
ASP A 159
GLY A 233
SER A 235
VAL A 254
 None
 0.89A 6c2mC-4jcnA:
7.9		 6c2mC-4jcnA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kpg MEMBRANE-ANCHORED
MYCOSIN MYCP1

(Mycolicibacterium
smegmatis) 		PF00082
(Peptidase_S8) 		5 HIS A 123
ASP A  92
GLY A 332
SER A 334
ALA A 204
 None
 1.05A 6c2mC-4kpgA:
undetectable		 6c2mC-4kpgA:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m1z MEMBRANE-ANCHORED
MYCOSIN MYCP1

(Mycolicibacterium
smegmatis) 		PF00082
(Peptidase_S8) 		5 HIS A 123
ASP A  92
GLY A 332
SER A 334
ALA A 204
 None
 0.97A 6c2mC-4m1zA:
undetectable		 6c2mC-4m1zA:
14.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mll BETA-LACTAMASE OXA-1

(Escherichia
coli) 		PF00905
(Transpeptidase) 		5 GLN A 125
VAL A 116
GLY A 128
ALA A  77
ALA A  80
 None
 1.00A 6c2mC-4mllA:
undetectable		 6c2mC-4mllA:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzd NISIN LEADER
PEPTIDE-PROCESSING
SERINE PROTEASE NISP

(Lactococcus
lactis) 		PF00082
(Peptidase_S8) 		5 HIS A 306
ASP A 259
GLY A 510
SER A 512
ALA A 364
 None
 0.70A 6c2mC-4mzdA:
undetectable		 6c2mC-4mzdA:
10.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nwk HCV NS3 1A PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		7 GLN A  41
ARG A 123
GLY A 137
SER A 139
PHE A 154
ALA A 157
VAL A 158
 2R8  A 301 ( 3.5A)
None
GOL  A 305 ( 3.2A)
2R8  A 301 (-2.6A)
2R8  A 301 (-3.7A)
2R8  A 301 (-3.8A)
2R8  A 301 ( 4.4A)
 0.90A 6c2mC-4nwkA:
35.5		 6c2mC-4nwkA:
95.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nwk HCV NS3 1A PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		10 GLN A  41
HIS A  57
VAL A  78
ASP A  81
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
VAL A 158
 2R8  A 301 ( 3.5A)
2R8  A 301 (-3.3A)
None
2R8  A 301 (-3.6A)
GOL  A 305 ( 3.2A)
2R8  A 301 (-2.6A)
2R8  A 301 (-3.7A)
2R8  A 301 (-3.1A)
2R8  A 301 (-3.8A)
2R8  A 301 ( 4.4A)
 0.46A 6c2mC-4nwkA:
35.5		 6c2mC-4nwkA:
95.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		6 GLN B 382
HIS B 226
ASP B 186
GLY B 384
SER B 386
ALA B 290
 None
 1.21A 6c2mC-4ov6B:
undetectable		 6c2mC-4ov6B:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w78 HYDRATASE CHSH1
HYDRATASE CHSH2

(Mycobacterium
tuberculosis;
Mycobacterium
tuberculosis) 		PF13452
(MaoC_dehydrat_N)
no annotation 		5 ARG A  55
GLY B  68
SER B  70
ALA A  56
ALA A  53
 None
 1.00A 6c2mC-4w78A:
undetectable		 6c2mC-4w78A:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x2x NS6 PROTEASE

(Norwalk virus) 		PF05416
(Peptidase_C37) 		5 HIS A  30
ASP A  54
GLY A 137
ALA A 159
ALA A 160
 None
 0.67A 6c2mC-4x2xA:
10.4		 6c2mC-4x2xA:
21.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x90 GROUP XV
PHOSPHOLIPASE A2

(Homo sapiens) 		PF02450
(LCAT) 		6 HIS A 359
VAL A 303
ASP A 327
GLY A  12
SER A 165
VAL A 191
 None
None
None
None
MPD  A 409 (-3.5A)
None
 1.43A 6c2mC-4x90A:
undetectable		 6c2mC-4x90A:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y5f BACTERIOPHYTOCHROME

(Deinococcus
radiodurans) 		PF01590
(GAF)
PF08446
(PAS_2) 		5 GLN A 262
ALA A 230
ALA A 231
VAL A 232
SER A  34
 None
 1.07A 6c2mC-4y5fA:
undetectable		 6c2mC-4y5fA:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b5h ANTIFREEZE PROTEIN

(Typhula
ishikariensis) 		PF11999
(DUF3494) 		5 GLY A 127
SER A 129
ALA A 154
ALA A 183
SER A 201
 None
NA  A1003 (-4.2A)
None
None
None
 0.97A 6c2mC-5b5hA:
undetectable		 6c2mC-5b5hA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxu FERULIC ACID
ESTERASE AMCE1/FAE1A

(Anaeromyces
mucronatus) 		PF00756
(Esterase) 		5 HIS A 253
ASP A 222
GLY A  64
SER A 156
SER A  77
 None
 0.95A 6c2mC-5cxuA:
undetectable		 6c2mC-5cxuA:
13.72
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eqq NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		10 GLN A1041
HIS A1057
VAL A1078
ASP A1081
ARG A1123
GLY A1137
PHE A1154
ALA A1156
ALA A1157
VAL A1158
 5RS  A1203 (-2.9A)
5RS  A1203 (-2.5A)
5RS  A1203 (-3.9A)
5RS  A1203 (-3.5A)
5RS  A1203 ( 3.3A)
5RS  A1203 (-3.2A)
5RS  A1203 (-3.3A)
5RS  A1203 (-2.9A)
5RS  A1203 (-3.5A)
5RS  A1203 ( 3.6A)
 0.33A 6c2mC-5eqqA:
35.5		 6c2mC-5eqqA:
98.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjj BETA-GLUCOSIDASE

(Aspergillus
oryzae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 HIS A 550
VAL A 502
GLY A 576
SER A 579
ALA A 398
 None
 1.00A 6c2mC-5fjjA:
undetectable		 6c2mC-5fjjA:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gj4 SERINE PROTEASE NS3

(Zika virus) 		PF00949
(Peptidase_S7) 		6 HIS B  51
VAL B  72
ASP B  75
GLY B 133
SER B 135
VAL B 162
 None
 1.02A 6c2mC-5gj4B:
6.6		 6c2mC-5gj4B:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7k ELONGATION FACTOR 2

(Pyrococcus
horikoshii) 		no annotation 5 ASP A  97
ARG A 349
GLY A 372
ALA A 312
VAL A 311
 None
 0.99A 6c2mC-5h7kA:
undetectable		 6c2mC-5h7kA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hc4 LIPOLYTIC ENZYME

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		6 HIS A 317
ASP A 287
ARG A 310
GLY A 107
SER A 188
SER A 330
 TRS  A 402 (-4.3A)
None
None
TRS  A 402 ( 3.8A)
TRS  A 402 (-2.3A)
None
 1.26A 6c2mC-5hc4A:
undetectable		 6c2mC-5hc4A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hc4 LIPOLYTIC ENZYME

(uncultured
bacterium) 		PF07859
(Abhydrolase_3) 		5 HIS A 317
ASP A 287
ARG A 310
GLY A 108
SER A 188
 TRS  A 402 (-4.3A)
None
None
TRS  A 402 (-3.3A)
TRS  A 402 (-2.3A)
 1.05A 6c2mC-5hc4A:
undetectable		 6c2mC-5hc4A:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ilb PROTEASE DO-LIKE 2,
CHLOROPLASTIC,PROTEA
SE DO-LIKE 9

(Arabidopsis
thaliana) 		PF13180
(PDZ_2)
PF13365
(Trypsin_2) 		5 HIS A 159
VAL A 187
ASP A 190
GLY A 266
SER A 268
 None
 0.76A 6c2mC-5ilbA:
13.0		 6c2mC-5ilbA:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxf ASP/GLU-SPECIFIC
DIPEPTIDYL-PEPTIDASE

(Flavobacterium
psychrophilum) 		PF10459
(Peptidase_S46) 		5 HIS A  83
ASP A 219
GLY A 642
SER A 644
VAL A 663
 ARG  A 801 (-3.6A)
None
ASP  A 802 (-3.8A)
ASP  A 802 (-2.5A)
None
 0.89A 6c2mC-5jxfA:
6.1		 6c2mC-5jxfA:
7.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mif 'CARBOXYL ESTERASE 2

(Tuber
melanosporum) 		PF07859
(Abhydrolase_3) 		5 HIS A 317
ASP A 287
GLY A 117
SER A 190
ALA A 320
 None
 1.05A 6c2mC-5mifA:
undetectable		 6c2mC-5mifA:
13.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrr LYTIC ENDOPEPTIDASE
PREPROENZYME

(Lysobacter sp.
XL1) 		no annotation 5 HIS A  36
VAL A  58
ASP A  63
GLY A 142
SER A 144
 None
 1.07A 6c2mC-5mrrA:
11.6		 6c2mC-5mrrA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbs BETA-GLUCOSIDASE

(Neurospora
crassa) 		no annotation 5 HIS A 545
VAL A 497
GLY A 571
SER A 574
ALA A 393
 None
 1.03A 6c2mC-5nbsA:
undetectable		 6c2mC-5nbsA:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5no5 ABYA5

(Verrucosispora) 		no annotation 5 HIS A 331
ASP A 304
GLY A 150
SER A 217
ALA A 239
 None
 1.01A 6c2mC-5no5A:
undetectable		 6c2mC-5no5A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5to3 PROTHROMBIN,THROMBOM
ODULIN

(Homo sapiens) 		PF00089
(Trypsin)
PF09064
(Tme5_EGF_like) 		5 HIS B  58
ASP B 114
GLY B 218
SER B 220
ALA B 242
 0G6  B 501 (-2.5A)
None
0G6  B 501 (-3.9A)
0G6  B 501 (-1.3A)
0G6  B 501 (-3.4A)
 0.72A 6c2mC-5to3B:
9.7		 6c2mC-5to3B:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vlh PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8)
PF05922
(Inhibitor_I9) 		6 GLN A 382
HIS A 226
ASP A 186
GLY A 384
SER A 386
ALA A 290
 None
 1.14A 6c2mC-5vlhA:
undetectable		 6c2mC-5vlhA:
11.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8o HOMOSERINE
O-ACETYLTRANSFERASE

(Mycolicibacterium
hassiacum) 		PF00561
(Abhydrolase_1) 		5 ASP A  51
SER A 372
ALA A 151
ALA A 152
VAL A 153
 None
 1.06A 6c2mC-5w8oA:
undetectable		 6c2mC-5w8oA:
11.86
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wdx JFH-1 NS3

(Hepacivirus C) 		no annotation 9 GLN A  41
HIS A  57
ARG A 123
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
VAL A 158
 None
 0.65A 6c2mC-5wdxA:
27.4		 6c2mC-5wdxA:
37.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wdx JFH-1 NS3

(Hepacivirus C) 		no annotation 9 HIS A  57
ASP A  81
ARG A 123
GLY A 137
SER A 139
PHE A 154
ALA A 156
ALA A 157
VAL A 158
 None
 0.40A 6c2mC-5wdxA:
27.4		 6c2mC-5wdxA:
37.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yfb DIPEPTIDYL PEPTIDASE
3

(Armillaria
tabescens) 		no annotation 5 GLN A  54
GLY A  49
SER A 249
ALA A 218
VAL A 217
 None
 1.02A 6c2mC-5yfbA:
undetectable		 6c2mC-5yfbA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ylv POTASSIUM-TRANSPORTI
NG ATPASE SUBUNIT
BETA

(Sus scrofa) 		no annotation 5 VAL B 259
GLY B 171
ALA B 247
ALA B 246
VAL B 245
 None
 0.81A 6c2mC-5ylvB:
undetectable		 6c2mC-5ylvB:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apg DISD PROTEIN

(Sorangium
cellulosum) 		no annotation 5 GLN A  58
VAL A 222
GLY A  10
ALA A 125
VAL A 126
 MLI  A 301 ( 4.6A)
None
None
None
None
 1.04A 6c2mC-6apgA:
undetectable		 6c2mC-6apgA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b5f NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE

(Yersinia
enterocolitica) 		no annotation 6 VAL A 114
ASP A 241
ALA A 182
ALA A 183
VAL A 186
SER A 187
 None
 1.38A 6c2mC-6b5fA:
undetectable		 6c2mC-6b5fA:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fkx ACETYL XYLAN
ESTERASE

(metagenome) 		no annotation 5 HIS C 304
ASP C 275
ARG C 297
GLY C  92
SER C 185
 None
 0.74A 6c2mC-6fkxC:
undetectable		 6c2mC-6fkxC:
20.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1atg PERIPLASMIC
MOLYBDATE-BINDING
PROTEIN

(Azotobacter
vinelandii) 		PF13531
(SBP_bac_11) 		5 PHE A 163
GLY A 122
ILE A  80
LYS A  82
ASP A  57
 None
 1.32A 6c2mC-1atgA:
undetectable		 6c2mC-1atgA:
15.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)

(Hepacivirus C) 		PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD) 		5 PHE A  43
VAL A  55
GLY A  58
LEU A 135
ASP A 168
 None
 0.27A 6c2mC-1cu1A:
34.7		 6c2mC-1cu1A:
47.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fho UNC-89

(Caenorhabditis
elegans) 		no annotation 5 GLY A   8
ILE A  57
LEU A  59
LYS A  36
ARG A  12
 None
 1.15A 6c2mC-1fhoA:
0.0		 6c2mC-1fhoA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz5 ALPHA-TREHALOSE-PHOS
PHATE SYNTHASE

(Escherichia
coli) 		PF00982
(Glyco_transf_20) 		5 VAL A   6
GLY A  40
LEU A 117
LYS A 115
ASP A 124
 None
 1.20A 6c2mC-1gz5A:
undetectable		 6c2mC-1gz5A:
11.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hbz CATALASE

(Micrococcus
luteus) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 GLY A 499
LEU A 454
LYS A 455
ARG A 458
ASP A 460
 None
 1.28A 6c2mC-1hbzA:
0.0		 6c2mC-1hbzA:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1htd ATROLYSIN C

(Crotalus atrox) 		PF01421
(Reprolysin) 		5 VAL A  33
ILE A 125
LEU A  97
ARG A  32
ASP A 128
 None
 1.45A 6c2mC-1htdA:
0.0		 6c2mC-1htdA:
18.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i9c GLUTAMATE MUTASE

(Clostridium
cochlearium) 		PF02310
(B12-binding) 		5 PHE A 108
VAL A 116
ILE A  86
ARG A 115
ASP A 133
 None
 1.34A 6c2mC-1i9cA:
undetectable		 6c2mC-1i9cA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iip CYCLOPHILIN 40

(Bos taurus) 		PF00160
(Pro_isomerase)
PF13176
(TPR_7) 		5 ILE A 161
LEU A 162
LYS A 160
ARG A  31
ASP A  21
 None
 1.34A 6c2mC-1iipA:
undetectable		 6c2mC-1iipA:
13.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k72 ENDOGLUCANASE 9G

([Clostridium]
cellulolyticum) 		PF00759
(Glyco_hydro_9)
PF00942
(CBM_3) 		5 VAL A 261
HIS A 262
GLY A 264
LEU A  73
ASP A 424
 None
 1.21A 6c2mC-1k72A:
undetectable		 6c2mC-1k72A:
10.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k94 GRANCALCIN

(Homo sapiens) 		PF13202
(EF-hand_5)
PF13833
(EF-hand_8) 		5 PHE A 191
GLY A 213
ILE A  98
LEU A 101
ASP A 104
 None
 1.44A 6c2mC-1k94A:
undetectable		 6c2mC-1k94A:
17.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kwc 2,3-DIHYDROXYBIPHENY
L DIOXYGENASE

(Pseudomonas sp.
KKS102) 		PF00903
(Glyoxalase) 		5 VAL B  99
GLY B 118
ILE B 143
LEU B   5
ARG B  97
 None
 1.45A 6c2mC-1kwcB:
undetectable		 6c2mC-1kwcB:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l0w ASPARTYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		5 VAL A 150
HIS A 148
LEU A 535
ARG A 147
ASP A 530
 None
 1.32A 6c2mC-1l0wA:
undetectable		 6c2mC-1l0wA:
8.82
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ns3 NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		5 PHE A  43
VAL A  55
GLY A  58
ARG A 155
ASP A 168
 None
 1.28A 6c2mC-1ns3A:
30.6		 6c2mC-1ns3A:
39.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ns3 NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		5 PHE A  43
VAL A  55
GLY A  58
LEU A 135
ASP A 168
 None
 0.79A 6c2mC-1ns3A:
30.6		 6c2mC-1ns3A:
39.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o1z GLYCEROPHOSPHODIESTE
R PHOSPHODIESTERASE

(Thermotoga
maritima) 		PF03009
(GDPD) 		5 VAL A 191
HIS A 164
GLY A 209
LEU A 217
ASP A 213
 None
 1.39A 6c2mC-1o1zA:
undetectable		 6c2mC-1o1zA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o8c YHDH

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 157
ILE A 298
LEU A 320
LYS A 296
ASP A  43
 NDP  A1325 (-3.1A)
None
None
None
None
 1.47A 6c2mC-1o8cA:
undetectable		 6c2mC-1o8cA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o8c YHDH

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 GLY A 157
ILE A 298
LEU A 320
LYS A 296
ASP A  64
 NDP  A1325 (-3.1A)
None
None
None
None
 1.31A 6c2mC-1o8cA:
undetectable		 6c2mC-1o8cA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pyf IOLS PROTEIN

(Bacillus
subtilis) 		PF00248
(Aldo_ket_red) 		5 VAL A 173
GLY A   7
ILE A  16
LEU A 276
ASP A  53
 None
EDO  A 313 (-3.3A)
None
None
None
 1.44A 6c2mC-1pyfA:
undetectable		 6c2mC-1pyfA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5v CITE

(Mycobacterium
tuberculosis) 		PF03328
(HpcH_HpaI) 		5 HIS A 161
ILE A 108
LEU A 176
ARG A 163
ASP A 179
 None
 1.14A 6c2mC-1u5vA:
undetectable		 6c2mC-1u5vA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v3y PEPTIDE DEFORMYLASE

(Thermus
thermophilus) 		PF01327
(Pep_deformylase) 		5 VAL A 113
GLY A  98
LEU A 105
ARG A 158
ASP A 148
 None
None
OCS  A 102 ( 4.4A)
None
None
 1.45A 6c2mC-1v3yA:
undetectable		 6c2mC-1v3yA:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wd5 HYPOTHETICAL PROTEIN
TT1426

(Thermus
thermophilus) 		PF00156
(Pribosyltran) 		5 VAL A  35
GLY A  29
LEU A 204
ARG A  32
ASP A 196
 None
 1.39A 6c2mC-1wd5A:
undetectable		 6c2mC-1wd5A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wy0 GERANYLGERANYL
PYROPHOSPHATE
SYNTHETASE

(Pyrococcus
horikoshii) 		PF00348
(polyprenyl_synt) 		5 VAL A 101
HIS A 102
ILE A  78
LEU A  77
ASP A 115
 None
 1.15A 6c2mC-1wy0A:
undetectable		 6c2mC-1wy0A:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yre HYPOTHETICAL PROTEIN
PA3270

(Pseudomonas
aeruginosa) 		PF13302
(Acetyltransf_3) 		5 VAL A 185
GLY A 151
LEU A 118
LYS A 116
ASP A 125
 None
 1.29A 6c2mC-1yreA:
undetectable		 6c2mC-1yreA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zup HYPOTHETICAL PROTEIN
TM1739

(Thermotoga
maritima) 		PF09376
(NurA) 		5 VAL A 219
ILE A  41
LEU A  42
ARG A 200
ASP A 251
 None
 1.17A 6c2mC-1zupA:
undetectable		 6c2mC-1zupA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b7u CHARYBDIN

(Drimia maritima) 		PF00161
(RIP) 		5 HIS A  41
GLY A  42
ILE A  28
LEU A  31
LYS A  29
 None
 1.21A 6c2mC-2b7uA:
undetectable		 6c2mC-2b7uA:
15.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cjs UNC-13 HOMOLOG A

(Rattus
norvegicus) 		PF00168
(C2) 		5 PHE A  51
VAL A  28
ILE A   0
LEU A   1
ARG A  55
 None
 1.32A 6c2mC-2cjsA:
undetectable		 6c2mC-2cjsA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dc4 165AA LONG
HYPOTHETICAL PROTEIN

(Pyrococcus
horikoshii) 		PF01928
(CYTH) 		5 VAL A 117
GLY A 121
LEU A 158
LYS A 157
ASP A  33
 None
None
CL  A 501 (-4.0A)
None
None
 1.40A 6c2mC-2dc4A:
undetectable		 6c2mC-2dc4A:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f5x BUGD

(Bordetella
pertussis) 		PF03401
(TctC) 		5 VAL A 193
GLY A 107
ILE A 157
LEU A 130
ASP A 179
 None
 1.47A 6c2mC-2f5xA:
undetectable		 6c2mC-2f5xA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r16 NEUREXIN-1-ALPHA

(Bos taurus) 		PF02210
(Laminin_G_2) 		5 PHE A 753
VAL A 819
ILE A 854
ARG A 820
ASP A 748
 None
 1.45A 6c2mC-2r16A:
undetectable		 6c2mC-2r16A:
16.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rin PUTATIVE GLYCINE
BETAINE-BINDING ABC
TRANSPORTER PROTEIN

(Sinorhizobium
meliloti) 		PF04069
(OpuAC) 		5 PHE A  86
HIS A 236
GLY A  88
ILE A  56
ASP A 251
 None
 1.38A 6c2mC-2rinA:
undetectable		 6c2mC-2rinA:
13.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vlt THIOREDOXIN H
ISOFORM 2.

(Hordeum vulgare) 		PF00085
(Thioredoxin) 		5 PHE A  63
VAL A 115
HIS A 118
ILE A  15
ASP A  40
 None
 1.47A 6c2mC-2vltA:
undetectable		 6c2mC-2vltA:
20.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w48 SORBITOL OPERON
REGULATOR

(Klebsiella
pneumoniae) 		PF04198
(Sugar-bind)
PF13936
(HTH_38) 		5 VAL A 137
GLY A 110
ILE A 279
LEU A 209
ASP A 104
 None
 1.28A 6c2mC-2w48A:
undetectable		 6c2mC-2w48A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wyh ALPHA-MANNOSIDASE

(Streptococcus
pyogenes) 		PF01074
(Glyco_hydro_38)
PF07748
(Glyco_hydro_38C)
PF09261
(Alpha-mann_mid) 		5 HIS A 349
ILE A  83
LEU A  51
ARG A  16
ASP A  60
 None
 0.97A 6c2mC-2wyhA:
undetectable		 6c2mC-2wyhA:
7.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aar ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE I

(Legionella
pneumophila) 		PF01150
(GDA1_CD39) 		5 VAL A 182
GLY A 183
ILE A 386
LEU A 390
ASP A 172
 None
 1.37A 6c2mC-3aarA:
undetectable		 6c2mC-3aarA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c10 HISTONE DEACETYLASE
7A

(Homo sapiens) 		PF00850
(Hist_deacetyl) 		5 VAL A 815
HIS A 814
GLY A 770
ILE A 727
ASP A 707
 None
None
None
None
ZN  A 101 (-2.1A)
 1.32A 6c2mC-3c10A:
undetectable		 6c2mC-3c10A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3chv PROKARYOTIC DOMAIN
OF UNKNOWN FUNCTION
(DUF849) WITH A TIM
BARREL FOLD

(Ruegeria
pomeroyi) 		PF05853
(BKACE) 		5 GLY A 209
ILE A 154
LEU A 151
ARG A 186
ASP A 190
 None
 1.33A 6c2mC-3chvA:
undetectable		 6c2mC-3chvA:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eq1 PORPHOBILINOGEN
DEAMINASE

(Homo sapiens) 		PF01379
(Porphobil_deam)
PF03900
(Porphobil_deamC) 		5 VAL A 267
HIS A 268
ILE A 350
LEU A 351
ARG A 149
 None
SO4  A 363 (-4.1A)
None
None
DPM  A 400 (-3.6A)
 1.33A 6c2mC-3eq1A:
undetectable		 6c2mC-3eq1A:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fa5 PROTEIN OF UNKNOWN
FUNCTION (DUF849)

(Paracoccus
denitrificans) 		PF05853
(BKACE) 		5 GLY A 177
ILE A 154
LEU A 151
ARG A 186
ASP A 190
 None
 1.18A 6c2mC-3fa5A:
undetectable		 6c2mC-3fa5A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fao NON-STRUCTURAL
PROTEIN

(Porcine
reproductive
and respiratory
syndrome virus) 		PF05579
(Peptidase_S32) 		5 VAL A 103
GLY A 105
LEU A 159
LYS A 158
ARG A  90
 None
 0.96A 6c2mC-3faoA:
8.6		 6c2mC-3faoA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcw PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		5 VAL A 234
HIS A 391
GLY A 394
ILE A 271
ASP A 186
 None
 1.32A 6c2mC-3gcwA:
undetectable		 6c2mC-3gcwA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE
FAD-SUBUNIT
NICOTINATE
DEHYDROGENASE SMALL
FES SUBUNIT

(Eubacterium
barkeri;
Eubacterium
barkeri) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C)
PF00111
(Fer2)
PF01799
(Fer2_2) 		5 VAL C  37
GLY C  33
ILE D   4
ARG D  24
ASP D  27
 None
FAD  C 900 (-3.3A)
None
None
None
 1.34A 6c2mC-3hrdC:
undetectable		 6c2mC-3hrdC:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrd NICOTINATE
DEHYDROGENASE
FAD-SUBUNIT
NICOTINATE
DEHYDROGENASE SMALL
FES SUBUNIT

(Eubacterium
barkeri;
Eubacterium
barkeri) 		PF00941
(FAD_binding_5)
PF03450
(CO_deh_flav_C)
PF00111
(Fer2)
PF01799
(Fer2_2) 		5 VAL C  37
GLY C  33
ILE D   6
ARG D  24
ASP D  27
 None
FAD  C 900 (-3.3A)
None
None
None
 0.93A 6c2mC-3hrdC:
undetectable		 6c2mC-3hrdC:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i8a DIHYDROFOLATE
REDUCTASE

(Staphylococcus
aureus) 		PF00186
(DHFR_1) 		5 VAL X  89
HIS X  38
LEU X  62
ARG X  58
ASP X  74
 None
None
NDP  X 207 (-4.0A)
None
None
 1.36A 6c2mC-3i8aX:
undetectable		 6c2mC-3i8aX:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ijl MUCONATE
CYCLOISOMERASE

(Bacteroides
thetaiotaomicron) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A 290
ILE A 250
LEU A 271
ARG A 321
ASP A 345
 None
 1.31A 6c2mC-3ijlA:
undetectable		 6c2mC-3ijlA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lyr TRANSCRIPTION FACTOR
COE1

(Homo sapiens) 		PF16422
(COE1_DBD) 		5 PHE A 190
VAL A 128
ILE A 159
LEU A 155
ARG A 129
 None
 1.18A 6c2mC-3lyrA:
undetectable		 6c2mC-3lyrA:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m1r FORMIMIDOYLGLUTAMASE

(Bacillus
subtilis) 		PF00491
(Arginase) 		5 VAL A 206
HIS A 204
GLY A 180
ILE A 239
ASP A 150
 None
None
None
None
CA  A 323 ( 2.7A)
 1.35A 6c2mC-3m1rA:
undetectable		 6c2mC-3m1rA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mqg LIPOPOLYSACCHARIDES
BIOSYNTHESIS
ACETYLTRANSFERASE

(Bordetella
petrii) 		PF00132
(Hexapep) 		5 HIS A  19
GLY A  17
LEU A  70
ARG A  55
ASP A  73
 None
 1.49A 6c2mC-3mqgA:
undetectable		 6c2mC-3mqgA:
15.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oq3 IFN-ALPHA/BETA
BINDING PROTEIN C12R

(Ectromelia
virus) 		PF00047
(ig)
PF13895
(Ig_2) 		5 VAL B  85
GLY B  88
ILE B 119
LEU B 105
ARG B  84
 None
 1.34A 6c2mC-3oq3B:
undetectable		 6c2mC-3oq3B:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ouu BIOTIN CARBOXYLASE

(Campylobacter
jejuni) 		PF00289
(Biotin_carb_N)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		5 PHE A  80
GLY A  82
ILE A  50
ARG A  11
ASP A  37
 None
 1.08A 6c2mC-3ouuA:
undetectable		 6c2mC-3ouuA:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oz2 DIGERANYLGERANYLGLYC
EROPHOSPHOLIPID
REDUCTASE

(Thermoplasma
acidophilum) 		PF01494
(FAD_binding_3) 		5 VAL A 134
GLY A 277
ILE A  32
ARG A 149
ASP A 147
 None
 1.35A 6c2mC-3oz2A:
undetectable		 6c2mC-3oz2A:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p9t REPRESSOR

(Stenotrophomonas
maltophilia) 		PF00440
(TetR_N)
PF08361
(TetR_C_2) 		5 VAL A 206
GLY A 205
ILE A  94
LEU A 194
ASP A  88
 None
 1.40A 6c2mC-3p9tA:
undetectable		 6c2mC-3p9tA:
17.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rtx MRNA-CAPPING ENZYME

(Mus musculus) 		PF01331
(mRNA_cap_enzyme)
PF03919
(mRNA_cap_C) 		5 PHE A 320
ILE A 304
LEU A 303
ARG A 299
ASP A 343
 None
None
None
GUN  A   1 (-3.8A)
GUN  A   1 (-3.3A)
 1.08A 6c2mC-3rtxA:
undetectable		 6c2mC-3rtxA:
12.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s3f TYROSINE-PROTEIN
PHOSPHATASE 10D

(Drosophila
melanogaster) 		PF00102
(Y_phosphatase) 		5 VAL A 117
HIS A 241
GLY A 245
ILE A 294
ASP A 256
 None
 1.34A 6c2mC-3s3fA:
undetectable		 6c2mC-3s3fA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uqz DNA PROCESSING
PROTEIN DPRA

(Streptococcus
pneumoniae) 		PF02481
(DNA_processg_A) 		5 HIS A 204
GLY A 168
LEU A 180
LYS A 178
ASP A 147
 None
None
None
SO4  A 302 (-4.0A)
None
 1.36A 6c2mC-3uqzA:
undetectable		 6c2mC-3uqzA:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vhj BFPC

(Escherichia
coli) 		no annotation 5 PHE A  80
VAL A 101
HIS A 108
GLY A 105
LEU A 155
 None
 1.18A 6c2mC-3vhjA:
undetectable		 6c2mC-3vhjA:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zqj UVRABC SYSTEM
PROTEIN A

(Mycobacterium
tuberculosis) 		PF00005
(ABC_tran) 		5 VAL A 834
GLY A 832
ILE A 724
ARG A 835
ASP A 803
 None
 1.37A 6c2mC-3zqjA:
undetectable		 6c2mC-3zqjA:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
43ca PROTEIN
(IMMUNOGLOBULIN
(HEAVY CHAIN))

(Mus musculus) 		PF07686
(V-set) 		5 VAL B 109
GLY B   8
ILE B  69
LEU B  67
LYS B  81
 None
 1.31A 6c2mC-43caB:
undetectable		 6c2mC-43caB:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arc LEUCINE--TRNA LIGASE

(Escherichia
coli) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		5 VAL A 835
GLY A 830
ILE A 848
LEU A 854
ARG A 811
 None
None
C  B  56 ( 3.7A)
G  B  19 ( 4.1A)
C  B  47 ( 2.9A)
 1.20A 6c2mC-4arcA:
undetectable		 6c2mC-4arcA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4doe 1,4-BETA-GLUCANASE

(Caldicellulosiruptor
bescii) 		PF00759
(Glyco_hydro_9) 		5 VAL A 284
HIS A 285
GLY A 287
LEU A  95
ASP A 447
 None
None
None
None
CT3  A 504 ( 4.5A)
 1.23A 6c2mC-4doeA:
undetectable		 6c2mC-4doeA:
9.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4p TYROSINE-PROTEIN
KINASE SYK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 GLY A 454
ILE A 432
LYS A 509
ARG A 498
ASP A 494
 0SB  A 701 (-3.5A)
None
None
None
None
 1.34A 6c2mC-4f4pA:
undetectable		 6c2mC-4f4pA:
13.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gaa MGC78867 PROTEIN

(Xenopus laevis) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		5 PHE A 585
VAL A 600
ILE A 548
ARG A 569
ASP A 570
 None
 1.36A 6c2mC-4gaaA:
undetectable		 6c2mC-4gaaA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ida RIPENING-INDUCED
PROTEIN

(Fragaria vesca) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		5 VAL A 175
HIS A 178
GLY A 176
ILE A 262
LEU A 263
 None
 1.23A 6c2mC-4idaA:
undetectable		 6c2mC-4idaA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l6u PUTATIVE
UNCHARACTERIZED
PROTEIN

(Archaeoglobus
fulgidus) 		PF03787
(RAMPs) 		5 VAL A 292
HIS A 291
GLY A 217
ILE A 313
ARG A 293
 None
 1.22A 6c2mC-4l6uA:
undetectable		 6c2mC-4l6uA:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m6r METHYLTHIORIBULOSE-1
-PHOSPHATE
DEHYDRATASE

(Homo sapiens) 		PF00596
(Aldolase_II) 		5 VAL A 197
HIS A 117
GLY A 196
ILE A 220
LEU A 217
 None
ZN  A 301 (-3.3A)
None
None
None
 1.35A 6c2mC-4m6rA:
undetectable		 6c2mC-4m6rA:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mm0 P450-LIKE
MONOOXYGENASE

(Streptomyces
griseoviridis) 		PF00067
(p450) 		5 VAL A 193
GLY A 191
ILE A 229
LEU A 230
ASP A 222
 None
 1.41A 6c2mC-4mm0A:
undetectable		 6c2mC-4mm0A:
12.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nwk HCV NS3 1A PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		7 PHE A  43
VAL A  55
GLY A  58
ILE A 132
LEU A 135
ARG A 155
ASP A 168
 2R8  A 301 (-4.6A)
None
2R8  A 301 (-3.5A)
2R8  A 301 (-4.3A)
2R8  A 301 (-4.4A)
2R8  A 301 (-3.6A)
2R8  A 301 ( 4.5A)
 0.41A 6c2mC-4nwkA:
35.5		 6c2mC-4nwkA:
95.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		5 VAL B 234
HIS B 391
GLY B 394
ILE B 271
ASP B 186
 None
 1.27A 6c2mC-4ov6B:
undetectable		 6c2mC-4ov6B:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qi7 CELLOBIOSE
DEHYDROGENASE

(Neurospora
crassa) 		PF00732
(GMC_oxred_N)
PF00734
(CBM_1)
PF05199
(GMC_oxred_C)
PF16010
(CDH-cyt) 		5 GLY A 348
ILE A 763
LEU A 764
LYS A 762
ASP A 246
 None
 1.24A 6c2mC-4qi7A:
undetectable		 6c2mC-4qi7A:
7.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rg8 EXONUCLEASE I

(Methylocaldum
szegediense) 		PF00929
(RNase_T)
PF08411
(Exonuc_X-T_C) 		5 VAL A 290
GLY A 289
ILE A 268
LEU A 267
ASP A 274
 None
 1.40A 6c2mC-4rg8A:
undetectable		 6c2mC-4rg8A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rjk ACETOLACTATE
SYNTHASE

(Bacillus
subtilis) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 VAL A 428
GLY A 427
ILE A 135
LEU A  96
ASP A 104
 None
 1.47A 6c2mC-4rjkA:
undetectable		 6c2mC-4rjkA:
10.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rws C-X-C CHEMOKINE
RECEPTOR TYPE
4/ENDOLYSIN CHIMERIC
PROTEIN

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme)
PF12109
(CXCR4_N) 		5 VAL A 156
GLY A 159
ILE A 215
LEU A 127
ASP A 133
 None
 1.30A 6c2mC-4rwsA:
undetectable		 6c2mC-4rwsA:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v20 CELLOBIOHYDROLASE

(Aspergillus
fumigatus) 		PF00840
(Glyco_hydro_7) 		5 VAL A  41
HIS A  42
ILE A 183
LEU A 180
ARG A  39
 None
ACT  A1444 (-4.6A)
None
None
None
 1.42A 6c2mC-4v20A:
undetectable		 6c2mC-4v20A:
12.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yj5 PYRUVATE KINASE PKM

(Homo sapiens) 		PF00224
(PK)
PF02887
(PK_C) 		5 VAL A  71
ILE A 267
LYS A 266
ARG A  73
ASP A 113
 None
None
None
PYR  A 601 ( 4.7A)
MG  A 602 (-3.4A)
 1.27A 6c2mC-4yj5A:
undetectable		 6c2mC-4yj5A:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yt9 PEPTIDYLARGININE
DEIMINASE

(Porphyromonas
gingivalis) 		PF04371
(PAD_porph) 		5 VAL A 193
HIS A 223
ILE A 300
LEU A 244
ASP A 238
 None
None
None
None
4GJ  A 351 ( 3.4A)
 1.42A 6c2mC-4yt9A:
undetectable		 6c2mC-4yt9A:
8.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zxo GLYCOSYL HYDROLASE
FAMILY 26

(Bacteroides
ovatus) 		PF02156
(Glyco_hydro_26) 		5 VAL A 253
ILE A 312
LEU A 274
ARG A 184
ASP A 257
 None
 1.48A 6c2mC-4zxoA:
undetectable		 6c2mC-4zxoA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT

(Azospira oryzae) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 PHE A 360
VAL A 372
ILE A 316
ARG A 283
ASP A 294
 None
 1.15A 6c2mC-5chcA:
undetectable		 6c2mC-5chcA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dkx ALPHA
GLUCOSIDASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF17137
(DUF5110) 		5 VAL A 100
ILE A 263
LEU A 261
ARG A 109
ASP A 377
 None
 1.43A 6c2mC-5dkxA:
undetectable		 6c2mC-5dkxA:
6.06
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eqq NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		8 PHE A1043
VAL A1055
GLY A1058
ILE A1132
LEU A1135
LYS A1136
ARG A1155
ASP A1168
 5RS  A1203 (-4.3A)
None
5RS  A1203 ( 2.9A)
5RS  A1203 ( 4.1A)
5RS  A1203 (-4.2A)
5RS  A1203 (-4.8A)
5RS  A1203 (-4.8A)
5RS  A1203 ( 4.0A)
 0.52A 6c2mC-5eqqA:
35.5		 6c2mC-5eqqA:
98.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fo1 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF

(Corynebacterium
ammoniagenes) 		PF01687
(Flavokinase)
PF06574
(FAD_syn) 		5 PHE A  84
VAL A  27
HIS A  28
ILE A  50
ARG A  77
 None
None
PPV  A1339 (-3.7A)
None
None
 1.33A 6c2mC-5fo1A:
undetectable		 6c2mC-5fo1A:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqt NITRILE-SPECIFIER
PROTEIN 1

(Arabidopsis
thaliana) 		PF01344
(Kelch_1)
PF01419
(Jacalin)
PF13415
(Kelch_3) 		5 VAL A 363
GLY A 362
LEU A 149
ARG A 416
ASP A 418
 None
 1.46A 6c2mC-5gqtA:
undetectable		 6c2mC-5gqtA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gqt NITRILE-SPECIFIER
PROTEIN 1

(Arabidopsis
thaliana) 		PF01344
(Kelch_1)
PF01419
(Jacalin)
PF13415
(Kelch_3) 		5 VAL A 363
GLY A 362
LYS A 148
ARG A 416
ASP A 418
 None
 1.37A 6c2mC-5gqtA:
undetectable		 6c2mC-5gqtA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hbt FAB35, HEAVY CHAIN

(Rattus
norvegicus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 VAL D 116
GLY D   8
ILE D  69
LEU D  67
LYS D  81
 None
 1.29A 6c2mC-5hbtD:
undetectable		 6c2mC-5hbtD:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hn4 HOMOISOCITRATE
DEHYDROGENASE

(Thermococcus
kodakarensis) 		PF00180
(Iso_dh) 		5 VAL A 293
GLY A 291
ILE A  97
ARG A 102
ASP A 100
 None
 1.45A 6c2mC-5hn4A:
0.0		 6c2mC-5hn4A:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1c WD REPEAT-CONTAINING
PROTEIN 20

(Homo sapiens) 		PF00400
(WD40) 		5 VAL C 152
GLY C 125
ILE C 130
LEU C 129
ASP C 105
 None
 1.50A 6c2mC-5k1cC:
undetectable		 6c2mC-5k1cC:
9.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mhf MANNOSYL-OLIGOSACCHA
RIDE GLUCOSIDASE

(Mus musculus) 		no annotation 5 HIS A 361
GLY A 156
LEU A 395
ARG A 153
ASP A 460
 None
 1.33A 6c2mC-5mhfA:
undetectable		 6c2mC-5mhfA:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncr TYROSINE PHOSPHATASE

(Orf virus) 		PF00782
(DSPc) 		5 VAL A 127
HIS A 129
GLY A 125
LEU A 148
ARG A 131
 None
 1.46A 6c2mC-5ncrA:
undetectable		 6c2mC-5ncrA:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ncs SERPIN

(Tannerella
forsythia) 		PF00079
(Serpin) 		5 PHE A 387
VAL A 386
GLY A 401
ILE A 287
ASP A 243
 None
 1.44A 6c2mC-5ncsA:
undetectable		 6c2mC-5ncsA:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ods CLATHRIN HEAVY CHAIN
1

(Mus musculus) 		no annotation 5 VAL A 478
GLY A 464
LEU A 427
ARG A 481
ASP A 455
 None
 1.37A 6c2mC-5odsA:
undetectable		 6c2mC-5odsA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5suo EXTRACELLULAR
SOLUTE-BINDING
PROTEIN

(Streptococcus
pneumoniae) 		PF12010
(DUF3502) 		5 VAL A 353
HIS A 382
GLY A 385
ILE A 338
LEU A 341
 None
 1.46A 6c2mC-5suoA:
undetectable		 6c2mC-5suoA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy5 ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR

(Mus musculus) 		PF00010
(HLH)
PF00989
(PAS)
PF14598
(PAS_11) 		5 VAL A 304
HIS A 302
LEU A 209
ARG A 266
ASP A 217
 None
 1.37A 6c2mC-5sy5A:
undetectable		 6c2mC-5sy5A:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u2p SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN

(Treponema
pallidum) 		PF01547
(SBP_bac_1) 		5 VAL A  40
GLY A  67
LEU A 333
ARG A 325
ASP A  95
 None
 1.49A 6c2mC-5u2pA:
undetectable		 6c2mC-5u2pA:
9.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wdx JFH-1 NS3

(Hepacivirus C) 		no annotation 6 PHE A  43
VAL A  55
GLY A  58
ILE A 132
LEU A 135
ASP A 168
 None
 0.49A 6c2mC-5wdxA:
27.4		 6c2mC-5wdxA:
37.01
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wdx JFH-1 NS3

(Hepacivirus C) 		no annotation 5 PHE A  43
VAL A  55
LEU A 135
ARG A 155
ASP A 168
 None
 1.42A 6c2mC-5wdxA:
27.4		 6c2mC-5wdxA:
37.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xau LAMININ SUBUNIT
ALPHA-5

(Homo sapiens) 		PF02210
(Laminin_G_2)
PF06009
(Laminin_II) 		5 VAL A3121
GLY A3122
LEU A2905
ARG A3275
ASP A2834
 None
 1.19A 6c2mC-5xauA:
undetectable		 6c2mC-5xauA:
8.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
ES4

(Toxoplasma
gondii) 		PF00467
(KOW)
PF00900
(Ribosomal_S4e)
PF01479
(S4)
PF08071
(RS4NT)
PF16121
(40S_S4_C) 		5 VAL E 227
GLY E 229
ILE E 169
LEU E 162
ARG E 125
 None
 1.50A 6c2mC-5xxuE:
undetectable		 6c2mC-5xxuE:
16.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yl7 PSEUDOALTEROMONAS
ARCTICA PAMC 21717

(Pseudoalteromonas
arctica) 		no annotation 5 VAL A 252
HIS A 430
GLY A 433
ILE A 291
ASP A 185
 None
 1.08A 6c2mC-5yl7A:
undetectable		 6c2mC-5yl7A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6blg DTDP-4-AMINO-4,6-DID
EOXYGALACTOSE
TRANSAMINASE

(Klebsiella
pneumoniae) 		no annotation 5 VAL A 131
HIS A 127
GLY A 130
ILE A 295
LEU A 279
 None
 1.46A 6c2mC-6blgA:
undetectable		 6c2mC-6blgA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d0s TBC1 DOMAIN FAMILY
MEMBER 22B

(Homo sapiens) 		no annotation 5 PHE A 319
VAL A 320
LEU A 358
ARG A 216
ASP A 428
 None
None
None
UNX  A 611 ( 4.2A)
None
 1.46A 6c2mC-6d0sA:
undetectable		 6c2mC-6d0sA:
26.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f9m SERINE PROTEASE

(Planococcus
plakortidis) 		no annotation 5 VAL A 118
GLY A 133
ILE A  63
LEU A 113
ASP A  82
 None
 1.44A 6c2mC-6f9mA:
undetectable		 6c2mC-6f9mA:
26.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fb3 TENEURIN-2

(Gallus gallus) 		no annotation 5 PHE A2453
GLY A2442
LEU A2539
ARG A2359
ASP A2353
 None
 1.21A 6c2mC-6fb3A:
undetectable		 6c2mC-6fb3A:
20.00