SIMILAR PATTERNS OF AMINO ACIDS FOR 6C2M_B_SUEB1202_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a87 COLICIN N

(Escherichia
coli) 		PF01024
(Colicin) 		5 ASP A 102
ARG A 108
ALA A 125
SER A 127
ASP A 124
 None
 1.14A 6c2mB-1a87A:
undetectable		 6c2mB-1a87A:
10.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1cu1 PROTEIN
(PROTEASE/HELICASE
NS3)

(Hepacivirus C) 		PF02907
(Peptidase_S29)
PF07652
(Flavi_DEAD) 		6 VAL A  55
ASP A  81
LEU A 135
ALA A 157
VAL A 158
ASP A 168
 None
 0.34A 6c2mB-1cu1A:
34.9		 6c2mB-1cu1A:
47.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cvm PHYTASE

(Bacillus
amyloliquefaciens) 		PF02333
(Phytase) 		5 LEU A 262
ARG A 289
ALA A 214
SER A 162
ASP A 216
 None
 1.38A 6c2mB-1cvmA:
0.0		 6c2mB-1cvmA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eye DIHYDROPTEROATE
SYNTHASE I

(Mycobacterium
tuberculosis) 		PF00809
(Pterin_bind) 		5 ASP A  21
LEU A 219
ARG A 212
ALA A 236
ASP A 234
 PMM  A 301 (-3.3A)
None
None
None
None
 1.38A 6c2mB-1eyeA:
undetectable		 6c2mB-1eyeA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fr9 MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN

(Escherichia
coli) 		PF12804
(NTP_transf_3) 		5 VAL A 169
HIS A 126
ARG A 112
ALA A 110
ASP A 108
 None
 1.13A 6c2mB-1fr9A:
undetectable		 6c2mB-1fr9A:
17.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jsw L-ASPARTATE
AMMONIA-LYASE

(Escherichia
coli) 		PF00206
(Lyase_1)
PF10415
(FumaraseC_C) 		5 VAL A 350
LEU A 379
ALA A 288
VAL A 289
SER A 292
 None
 1.28A 6c2mB-1jswA:
undetectable		 6c2mB-1jswA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l0w ASPARTYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		5 VAL A 150
HIS A 148
LEU A 535
ALA A 534
ASP A 530
 None
 0.97A 6c2mB-1l0wA:
0.0		 6c2mB-1l0wA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l0w ASPARTYL-TRNA
SYNTHETASE

(Thermus
thermophilus) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon)
PF02938
(GAD) 		5 VAL A 150
HIS A 148
LEU A 535
ARG A 147
ASP A 530
 None
 1.34A 6c2mB-1l0wA:
0.0		 6c2mB-1l0wA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m66 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Leishmania
mexicana) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		5 VAL A 255
LEU A 248
ARG A 242
ALA A 247
ASP A 243
 None
 1.37A 6c2mB-1m66A:
0.0		 6c2mB-1m66A:
10.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m6s L-ALLO-THREONINE
ALDOLASE

(Thermotoga
maritima) 		PF01212
(Beta_elim_lyase) 		5 VAL A  76
HIS A 101
LEU A  95
ALA A  91
VAL A  89
 None
 1.22A 6c2mB-1m6sA:
undetectable		 6c2mB-1m6sA:
12.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n3s GTP CYCLOHYDROLASE I

(Escherichia
coli) 		PF01227
(GTP_cyclohydroI) 		5 VAL A 217
LEU A 106
ARG A 218
ALA A 177
VAL A 178
 None
 1.17A 6c2mB-1n3sA:
undetectable		 6c2mB-1n3sA:
18.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ns3 NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		5 VAL A  55
ASP A  81
LEU A 135
ALA A 157
ASP A 168
 None
 0.85A 6c2mB-1ns3A:
18.2		 6c2mB-1ns3A:
39.37
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1ns3 NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		5 VAL A  55
ASP A  81
LEU A 135
ALA A 157
VAL A 158
 None
 0.42A 6c2mB-1ns3A:
18.2		 6c2mB-1ns3A:
39.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ohq IMMUNOGLOBULIN

(Homo sapiens) 		PF07686
(V-set) 		5 ARG A  38
ALA A  88
VAL A 118
SER A 119
ASP A  90
 None
 1.38A 6c2mB-1ohqA:
undetectable		 6c2mB-1ohqA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1okg POSSIBLE
3-MERCAPTOPYRUVATE
SULFURTRANSFERASE

(Leishmania
major) 		PF00581
(Rhodanese)
PF09122
(DUF1930) 		5 ASP A 103
LEU A 113
ARG A  34
ALA A  58
ASP A  32
 None
 1.15A 6c2mB-1okgA:
undetectable		 6c2mB-1okgA:
15.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sqg SUN PROTEIN

(Escherichia
coli) 		PF01029
(NusB)
PF01189
(Methyltr_RsmB-F) 		5 VAL A 209
LEU A 191
ARG A 185
ALA A 190
ASP A 186
 None
 1.22A 6c2mB-1sqgA:
undetectable		 6c2mB-1sqgA:
10.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xz9 AFADIN

(Homo sapiens) 		PF00595
(PDZ) 		5 ASP A  61
LEU A  17
ALA A  50
VAL A  53
ASP A  52
 None
 1.33A 6c2mB-1xz9A:
undetectable		 6c2mB-1xz9A:
22.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z34 PURINE NUCLEOSIDE
PHOSPHORYLASE

(Trichomonas
vaginalis) 		PF01048
(PNP_UDP_1) 		5 HIS A  99
ASP A 102
LEU A 144
ALA A 141
VAL A 138
 None
 1.35A 6c2mB-1z34A:
undetectable		 6c2mB-1z34A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ark FLAVODOXIN

(Aquifex
aeolicus) 		PF00258
(Flavodoxin_1) 		5 VAL A 162
ASP A  51
LEU A 154
ALA A  54
VAL A  55
 None
 1.22A 6c2mB-2arkA:
undetectable		 6c2mB-2arkA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b1p MITOGEN-ACTIVATED
PROTEIN KINASE 10

(Homo sapiens) 		PF00069
(Pkinase) 		5 VAL A 361
LEU A 335
ALA A 353
VAL A 350
SER A 349
 None
 1.32A 6c2mB-2b1pA:
0.7		 6c2mB-2b1pA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b39 C3

(Bos taurus) 		PF00207
(A2M)
PF01759
(NTR)
PF01821
(ANATO)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2)
PF10569
(Thiol-ester_cl) 		5 VAL A1306
LEU A 946
ARG A1307
ALA A1333
ASP A1294
 None
 1.24A 6c2mB-2b39A:
undetectable		 6c2mB-2b39A:
4.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gn4 UDP-GLCNAC C6
DEHYDRATASE

(Helicobacter
pylori) 		PF02719
(Polysacc_synt_2) 		5 VAL A  93
HIS A  92
LEU A 146
ALA A 134
ASP A 132
 UD1  A 335 ( 4.9A)
UD1  A 335 (-3.7A)
None
None
UD1  A 335 (-2.6A)
 1.36A 6c2mB-2gn4A:
undetectable		 6c2mB-2gn4A:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hb6 LEUCINE
AMINOPEPTIDASE 1

(Caenorhabditis
elegans) 		PF00883
(Peptidase_M17) 		5 VAL A 255
LEU A 283
ALA A 193
VAL A 194
ASP A 191
 None
 1.36A 6c2mB-2hb6A:
undetectable		 6c2mB-2hb6A:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2mcp IGA-KAPPA MCPC603
FAB (HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ARG H  38
ALA H  90
VAL H 120
SER H 121
ASP H  92
 None
 1.38A 6c2mB-2mcpH:
undetectable		 6c2mB-2mcpH:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nun AVIRULENCE B PROTEIN

(Pseudomonas
savastanoi) 		PF05394
(AvrB_AvrC) 		5 LEU A  91
ARG A  82
ALA A  76
SER A  72
ASP A  78
 None
 1.03A 6c2mB-2nunA:
undetectable		 6c2mB-2nunA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2odp COMPLEMENT C2

(Homo sapiens) 		PF00089
(Trypsin)
PF00092
(VWA) 		5 ASP A 707
LEU A 600
ALA A 599
VAL A 598
SER A 603
 None
None
NAG  A 807 ( 4.8A)
None
NAG  A 807 (-3.4A)
 1.38A 6c2mB-2odpA:
9.4		 6c2mB-2odpA:
9.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qop HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ACRR

(Escherichia
coli) 		PF00440
(TetR_N)
PF08361
(TetR_C_2) 		5 LEU A  58
ARG A 105
ALA A  20
VAL A  19
ASP A  18
 None
 1.11A 6c2mB-2qopA:
undetectable		 6c2mB-2qopA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r6r CELL DIVISION
PROTEIN FTSZ

(Aquifex
aeolicus) 		PF00091
(Tubulin)
PF12327
(FtsZ_C) 		5 VAL 1 182
ASP 1 183
LEU 1 101
ALA 1  99
VAL 1  15
 GDP  1 339 (-4.3A)
GDP  1 339 (-3.2A)
None
None
None
 1.23A 6c2mB-2r6r1:
undetectable		 6c2mB-2r6r1:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnr PROBABLE EXOSOME
COMPLEX EXONUCLEASE
2
PROBABLE EXOSOME
COMPLEX EXONUCLEASE
1

(Methanothermobacter
thermautotrophicus;
Methanothermobacter
thermautotrophicus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C)
PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 VAL A 247
LEU B 207
ARG A 244
ALA B 215
ASP B 217
 None
 1.38A 6c2mB-2wnrA:
undetectable		 6c2mB-2wnrA:
14.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xnd ATP SYNTHASE SUBUNIT
DELTA, MITOCHONDRIAL

(Bos taurus) 		PF02823
(ATP-synt_DE_N) 		5 VAL H  36
HIS H  66
LEU H  93
ALA H  21
VAL H  26
 None
 1.14A 6c2mB-2xndH:
undetectable		 6c2mB-2xndH:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y96 DUAL SPECIFICITY
PHOSPHATASE DUPD1

(Homo sapiens) 		PF00782
(DSPc) 		5 VAL A 111
HIS A  89
LEU A 159
ARG A 153
ALA A 155
 None
None
None
SO4  A1207 (-3.8A)
None
 1.28A 6c2mB-2y96A:
undetectable		 6c2mB-2y96A:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a9l POLY-GAMMA-GLUTAMATE
HYDROLASE

(Bacillus virus
NIT1) 		PF05908
(Gamma_PGA_hydro) 		5 LEU A  93
ALA A  99
VAL A 100
SER A 101
ASP A  98
 None
 1.22A 6c2mB-3a9lA:
undetectable		 6c2mB-3a9lA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b95 EUCHROMATIC
HISTONE-LYSINE
N-METHYLTRANSFERASE
1

(Homo sapiens) 		PF12796
(Ank_2)
PF13637
(Ank_4) 		5 HIS A 907
ASP A 909
LEU A 945
VAL A 954
SER A 952
 None
 1.27A 6c2mB-3b95A:
undetectable		 6c2mB-3b95A:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6n DIHYDROOROTASE

(Aquifex
aeolicus) 		PF01979
(Amidohydro_1) 		5 VAL A  62
HIS A  61
ASP A  59
LEU A 392
ALA A  84
 None
ZN  A 423 (-3.5A)
None
None
None
 1.30A 6c2mB-3d6nA:
undetectable		 6c2mB-3d6nA:
13.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fpl NADP-DEPENDENT
ALCOHOL
DEHYDROGENASE

(Clostridium
beijerinckii;
Thermoanaerobacter
brockii) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A 202
LEU A 336
ALA A 347
VAL A 348
SER A  35
 None
 1.11A 6c2mB-3fplA:
undetectable		 6c2mB-3fplA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hpa AMIDOHYDROLASE

(unidentified) 		PF01979
(Amidohydro_1) 		5 VAL A 237
LEU A 256
ALA A 246
VAL A 247
ASP A 244
 None
 1.28A 6c2mB-3hpaA:
undetectable		 6c2mB-3hpaA:
9.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i6b 3-DEOXY-D-MANNO-OCTU
LOSONATE 8-PHOSPHATE
PHOSPHATASE

(Escherichia
coli) 		PF08282
(Hydrolase_3) 		5 VAL A  36
ASP A  32
LEU A 173
ALA A 121
VAL A 120
 None
PO4  A 800 ( 4.3A)
None
None
None
 1.33A 6c2mB-3i6bA:
undetectable		 6c2mB-3i6bA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ijm UNCHARACTERIZED
RESTRICTION
ENDONUCLEASE-LIKE
FOLD SUPERFAMILY
PROTEIN

(Spirosoma
linguale) 		no annotation 5 LEU A 121
ARG A 124
ALA A 131
VAL A 130
ASP A 127
 None
SO4  A 150 (-2.7A)
None
None
None
 1.38A 6c2mB-3ijmA:
undetectable		 6c2mB-3ijmA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3is5 CALCIUM-DEPENDENT
PROTEIN KINASE

(Toxoplasma
gondii) 		PF00069
(Pkinase) 		5 VAL A 387
HIS A 389
LEU A 330
ALA A 366
ASP A 368
 None
 1.39A 6c2mB-3is5A:
undetectable		 6c2mB-3is5A:
13.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kat NACHT, LRR AND PYD
DOMAINS-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00619
(CARD) 		5 VAL A1382
HIS A1380
ASP A1383
LEU A1408
ARG A1386
 None
 1.26A 6c2mB-3katA:
undetectable		 6c2mB-3katA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mn1 PROBABLE YRBI FAMILY
PHOSPHATASE

(Pseudomonas
savastanoi) 		PF08282
(Hydrolase_3) 		5 VAL A  61
LEU A 171
ALA A 174
VAL A 177
SER A 176
 None
 1.33A 6c2mB-3mn1A:
undetectable		 6c2mB-3mn1A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvu TENA FAMILY
TRANSCRIPTIONAL
REGULATOR

(Ruegeria sp.
TM1040) 		PF03070
(TENA_THI-4) 		5 VAL A 141
LEU A 133
ALA A  63
VAL A  64
SER A  67
 EDO  A 237 ( 4.2A)
None
None
None
None
 1.33A 6c2mB-3mvuA:
undetectable		 6c2mB-3mvuA:
16.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ncy ADIC

(Salmonella
enterica) 		PF13520
(AA_permease_2) 		5 VAL A 207
LEU A 201
ALA A 401
VAL A 402
SER A 405
 None
 1.35A 6c2mB-3ncyA:
undetectable		 6c2mB-3ncyA:
10.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyf D-ARGININE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF01266
(DAO) 		5 VAL A1177
LEU A1209
ARG A1176
ALA A1210
VAL A1212
 None
 1.36A 6c2mB-3nyfA:
undetectable		 6c2mB-3nyfA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppl ASPARTATE
AMINOTRANSFERASE

(Corynebacterium
glutamicum) 		PF12897
(Aminotran_MocR) 		5 VAL A 416
LEU A  37
ALA A 408
VAL A 407
ASP A 410
 None
 1.29A 6c2mB-3pplA:
undetectable		 6c2mB-3pplA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6p CAPSID PROTEIN

(Helicoverpa
armigera stunt
virus) 		PF03566
(Peptidase_A21) 		5 LEU A 193
ARG A 164
VAL A 480
SER A 481
ASP A 501
 None
 1.30A 6c2mB-3s6pA:
undetectable		 6c2mB-3s6pA:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u9w LEUKOTRIENE A-4
HYDROLASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF09127
(Leuk-A4-hydro_C) 		5 ASP A1578
LEU A1555
ALA A1584
VAL A1585
ASP A1582
 None
 1.17A 6c2mB-3u9wA:
undetectable		 6c2mB-3u9wA:
8.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3usz EXO-1,3/1,4-BETA-GLU
CANASE

(Pseudoalteromonas
sp. BB1) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C) 		5 HIS A 114
LEU A 137
ALA A 392
VAL A 393
SER A 396
 None
 1.36A 6c2mB-3uszA:
undetectable		 6c2mB-3uszA:
5.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v4o MUCOSA-ASSOCIATED
LYMPHOID TISSUE
LYMPHOMA
TRANSLOCATION
PROTEIN 1

(Homo sapiens) 		PF00656
(Peptidase_C14) 		5 VAL A 406
ASP A 342
LEU A 410
VAL A 381
SER A 382
 None
 1.34A 6c2mB-3v4oA:
undetectable		 6c2mB-3v4oA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vth HYDROGENASE
MATURATION FACTOR

(Caldanaerobacter
subterraneus) 		PF00708
(Acylphosphatase)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		5 VAL A 594
LEU A 556
ARG A 599
ALA A 555
ASP A 602
 None
None
AP2  A 806 (-4.1A)
None
None
 1.20A 6c2mB-3vthA:
undetectable		 6c2mB-3vthA:
7.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vu1 PUTATIVE
UNCHARACTERIZED
PROTEIN PH0242

(Pyrococcus
horikoshii) 		no annotation 5 LEU A 800
ARG A 768
VAL A 557
SER A 555
ASP A 558
 None
CL  A1002 (-3.4A)
None
None
None
 1.08A 6c2mB-3vu1A:
0.0		 6c2mB-3vu1A:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zok 3-DEHYDROQUINATE
SYNTHASE

(Actinidia
chinensis) 		PF01761
(DHQ_synthase) 		5 LEU A 349
ARG A 295
ALA A 289
VAL A 287
ASP A 291
 None
None
PO4  A1380 (-3.2A)
None
None
 1.27A 6c2mB-3zokA:
undetectable		 6c2mB-3zokA:
12.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3u NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE

(Zymomonas
mobilis) 		PF00724
(Oxidored_FMN) 		5 HIS A 238
ASP A 236
LEU A 204
ARG A 184
ASP A 180
 None
 1.09A 6c2mB-4a3uA:
undetectable		 6c2mB-4a3uA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a3u NADH:FLAVIN
OXIDOREDUCTASE/NADH
OXIDASE

(Zymomonas
mobilis) 		PF00724
(Oxidored_FMN) 		5 VAL A 242
ASP A 236
LEU A 204
ARG A 184
ASP A 180
 None
 1.00A 6c2mB-4a3uA:
undetectable		 6c2mB-4a3uA:
14.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bmr RIBONUCLEOSIDE-DIPHO
SPHATE REDUCTASE
SUBUNIT BETA

(Bacillus cereus) 		PF00268
(Ribonuc_red_sm) 		5 ASP A  12
LEU A  77
ALA A  82
VAL A  85
SER A  84
 None
 1.09A 6c2mB-4bmrA:
undetectable		 6c2mB-4bmrA:
13.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c25 L-FUCULOSE PHOSPHATE
ALDOLASE

(Streptococcus
pneumoniae) 		PF00596
(Aldolase_II) 		5 ASP A  87
ALA A  90
VAL A  30
SER A  29
ASP A  89
 EDO  A 306 ( 3.8A)
None
None
None
None
 1.26A 6c2mB-4c25A:
undetectable		 6c2mB-4c25A:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c8q SM-LIKE PROTEIN LSM1
U6 SNRNA-ASSOCIATED
SM-LIKE PROTEIN LSM2

(Saccharomyces
cerevisiae;
Saccharomyces
cerevisiae) 		PF01423
(LSM)
PF01423
(LSM) 		5 VAL A 109
LEU B  40
ARG B  63
VAL B  32
SER B  31
 None
 1.10A 6c2mB-4c8qA:
undetectable		 6c2mB-4c8qA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cpd ALCOHOL
DEHYDROGENASE

(Thermus sp.
ATN1) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A  82
LEU A 305
ARG A 136
ALA A 304
ASP A 300
 None
 1.04A 6c2mB-4cpdA:
undetectable		 6c2mB-4cpdA:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dd8 DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 8

(Homo sapiens) 		PF01421
(Reprolysin) 		5 VAL A 222
HIS A 224
LEU A 290
ARG A 225
ASP A 320
 None
 1.30A 6c2mB-4dd8A:
undetectable		 6c2mB-4dd8A:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gp1 POLYPRENYL
SYNTHETASE

(Pyrobaculum
calidifontis) 		PF00348
(polyprenyl_synt) 		5 LEU A 290
ARG A 276
ALA A 287
VAL A 284
ASP A 283
 None
 1.30A 6c2mB-4gp1A:
undetectable		 6c2mB-4gp1A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ia5 MYOSIN-CROSSREACTIVE
ANTIGEN

(Lactobacillus
acidophilus) 		PF06100
(MCRA) 		5 ASP A 416
LEU A 388
ARG A 425
VAL A 345
SER A 346
 None
 1.22A 6c2mB-4ia5A:
undetectable		 6c2mB-4ia5A:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ls5 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Bacillus
subtilis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 VAL A 104
LEU A  13
ALA A  12
VAL A  20
SER A  23
 None
None
None
GOL  A 503 ( 4.8A)
None
 1.27A 6c2mB-4ls5A:
undetectable		 6c2mB-4ls5A:
12.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nf2 ORNITHINE
CARBAMOYLTRANSFERASE

(Bacillus
anthracis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		5 LEU A 118
ALA A  95
VAL A  97
SER A  99
ASP A  93
 None
 1.03A 6c2mB-4nf2A:
undetectable		 6c2mB-4nf2A:
13.08
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4nwk HCV NS3 1A PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		7 VAL A  55
ASP A  81
LEU A 135
ARG A 155
ALA A 157
VAL A 158
ASP A 168
 None
2R8  A 301 (-3.6A)
2R8  A 301 (-4.4A)
2R8  A 301 (-3.6A)
2R8  A 301 (-3.8A)
2R8  A 301 ( 4.4A)
2R8  A 301 ( 4.5A)
 0.28A 6c2mB-4nwkA:
35.5		 6c2mB-4nwkA:
95.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4od1 CAP256-VRC26.03
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ARG H  38
ALA H  84
VAL H 111
SER H 112
ASP H  86
 None
 1.38A 6c2mB-4od1H:
undetectable		 6c2mB-4od1H:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pe5 GLUTAMATE RECEPTOR
IONOTROPIC, NMDA 2B

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 VAL B 258
LEU B 249
ALA B 244
VAL B 243
SER B 246
 None
 1.26A 6c2mB-4pe5B:
undetectable		 6c2mB-4pe5B:
7.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4upl SULFATASE FAMILY
PROTEIN

(Ruegeria
pomeroyi) 		PF00884
(Sulfatase)
PF16347
(DUF4976) 		5 HIS A 409
LEU A 463
ARG A 412
ALA A 443
VAL A 442
 None
 1.36A 6c2mB-4uplA:
undetectable		 6c2mB-4uplA:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wis LIPID SCRAMBLASE

([Nectria]
haematococca) 		PF04547
(Anoctamin) 		5 VAL A  92
HIS A  90
ASP A  87
ARG A  93
VAL A 111
 None
 1.28A 6c2mB-4wisA:
undetectable		 6c2mB-4wisA:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x9s PHOSPHORIBOSYL
ISOMERASE A

(Streptomyces
sp. Mg1) 		PF00977
(His_biosynth) 		5 VAL A  69
ASP A  55
ALA A  19
SER A  32
ASP A  13
 None
None
None
None
SO4  A 305 (-2.8A)
 1.32A 6c2mB-4x9sA:
undetectable		 6c2mB-4x9sA:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a31 ANAPHASE-PROMOTING
COMPLEX SUBUNIT 5

(Homo sapiens) 		PF12862
(ANAPC5) 		5 LEU O 446
ARG O 430
ALA O 469
VAL O 468
SER O 465
 None
 1.10A 6c2mB-5a31O:
undetectable		 6c2mB-5a31O:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amq RNA POLYMERASE L

(California
encephalitis
orthobunyavirus) 		PF04196
(Bunya_RdRp)
PF15518
(L_protein_N) 		5 VAL A1386
LEU A1357
VAL A1572
SER A1575
ASP A1569
 None
 1.30A 6c2mB-5amqA:
undetectable		 6c2mB-5amqA:
2.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aza MALTOSE-BINDING
PERIPLASMIC
PROTEIN,OLIGOSACCHAR
YL TRANSFERASE STT3
SUBUNIT RELATED
PROTEIN

(Escherichia
coli;
Pyrococcus
furiosus) 		PF13416
(SBP_bac_8) 		5 LEU A 692
ARG A 660
VAL A 453
SER A 451
ASP A 454
 None
 1.14A 6c2mB-5azaA:
undetectable		 6c2mB-5azaA:
6.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b04 PROBABLE TRANSLATION
INITIATION FACTOR
EIF-2B SUBUNIT GAMMA

(Schizosaccharomyces
pombe) 		PF00483
(NTP_transferase) 		5 VAL E 249
HIS E 247
LEU E 205
ALA E 172
VAL E 173
 None
 1.31A 6c2mB-5b04E:
undetectable		 6c2mB-5b04E:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d6o HOMOSERINE
O-ACETYLTRANSFERASE

(Corynebacterium
glutamicum) 		PF00561
(Abhydrolase_1) 		5 LEU A  36
ARG A 127
ALA A 121
VAL A 119
ASP A 123
 None
GOL  A 408 (-4.3A)
None
None
None
 1.23A 6c2mB-5d6oA:
undetectable		 6c2mB-5d6oA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9u GLYCOSYLTRANSFERASE
GTF1

(Streptococcus
gordonii) 		PF00534
(Glycos_transf_1) 		5 LEU A 311
ARG A 488
ALA A 481
VAL A 480
SER A 477
 None
 1.14A 6c2mB-5e9uA:
undetectable		 6c2mB-5e9uA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e9u GLYCOSYLTRANSFERASE
GTF1

(Streptococcus
gordonii) 		PF00534
(Glycos_transf_1) 		5 VAL A 489
LEU A 311
ARG A 488
ALA A 481
SER A 477
 None
 1.09A 6c2mB-5e9uA:
undetectable		 6c2mB-5e9uA:
9.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eks 3-DEHYDROQUINATE
SYNTHASE

(Acinetobacter
baumannii) 		PF01761
(DHQ_synthase) 		5 LEU A 333
ARG A 280
ALA A 274
VAL A 272
ASP A 276
 None
 1.16A 6c2mB-5eksA:
undetectable		 6c2mB-5eksA:
13.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eks 3-DEHYDROQUINATE
SYNTHASE

(Acinetobacter
baumannii) 		PF01761
(DHQ_synthase) 		5 LEU A 333
ARG A 280
ALA A 275
VAL A 272
ASP A 276
 None
 1.38A 6c2mB-5eksA:
undetectable		 6c2mB-5eksA:
13.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5eqq NS3 PROTEASE

(Hepacivirus C) 		PF02907
(Peptidase_S29) 		7 VAL A1055
ASP A1081
LEU A1135
ARG A1155
ALA A1157
VAL A1158
ASP A1168
 None
5RS  A1203 (-3.5A)
5RS  A1203 (-4.2A)
5RS  A1203 (-4.8A)
5RS  A1203 (-3.5A)
5RS  A1203 ( 3.6A)
5RS  A1203 ( 4.0A)
 0.27A 6c2mB-5eqqA:
35.9		 6c2mB-5eqqA:
98.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f2o FATTY ACID
O-METHYLTRANSFERASE

(Mycobacterium
marinum) 		PF03492
(Methyltransf_7) 		5 ASP A  98
LEU A 139
ALA A  95
VAL A  94
ASP A  62
 SAH  A 400 (-2.8A)
None
None
None
None
 1.36A 6c2mB-5f2oA:
undetectable		 6c2mB-5f2oA:
13.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g52 VP3

(Deformed wing
virus) 		PF00073
(Rhv) 		5 VAL C 228
LEU C 121
ARG C  66
ALA C  85
SER C 204
 None
 0.92A 6c2mB-5g52C:
undetectable		 6c2mB-5g52C:
10.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k1s OXIDOREDUCTASE,
ZINC-BINDING
DEHYDROGENASE FAMILY

(Myxococcus
xanthus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 HIS A   0
LEU A  60
ALA A  58
VAL A  56
SER A  55
 None
 1.30A 6c2mB-5k1sA:
undetectable		 6c2mB-5k1sA:
14.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m0t ALPHA-KETOGLUTARATE-
DEPENDENT NON-HEME
IRON OXYGENASE EASH

(Aspergillus
japonicus) 		PF05721
(PhyH) 		5 VAL A  44
LEU A 155
ALA A 200
VAL A  34
ASP A 199
 None
None
None
None
ZN  A 305 (-2.7A)
 1.37A 6c2mB-5m0tA:
undetectable		 6c2mB-5m0tA:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m6g BETA-GLUCOSIDASE

(Saccharopolyspora
erythraea) 		no annotation 5 HIS A 134
LEU A 157
ALA A 408
VAL A 409
SER A 412
 None
 1.25A 6c2mB-5m6gA:
undetectable		 6c2mB-5m6gA:
8.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnl INACTIVE
DIHYDROOROTASE-LIKE
DOMAIN

(Chaetomium
thermophilum) 		no annotation 5 VAL A1548
LEU A1594
ALA A1580
VAL A1579
SER A1576
 None
 1.28A 6c2mB-5nnlA:
undetectable		 6c2mB-5nnlA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osg RNA BINDING PROTEIN,
PUTATIVE

(Leishmania
donovani) 		no annotation 5 VAL h  80
LEU h  85
ALA h  68
VAL h  67
SER h  66
 None
 0.97A 6c2mB-5osgh:
undetectable		 6c2mB-5osgh:
16.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tqi PYRIDOXAL KINASE
PDXY

(Burkholderia
multivorans) 		PF08543
(Phos_pyr_kin) 		5 VAL A 248
HIS A 249
ALA A 240
VAL A 237
SER A 236
 None
 1.21A 6c2mB-5tqiA:
undetectable		 6c2mB-5tqiA:
16.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u68 MPE8

(Homo sapiens) 		PF07686
(V-set) 		5 ARG E  57
ALA E 107
VAL E 141
SER E 142
ASP E 109
 None
 1.35A 6c2mB-5u68E:
undetectable		 6c2mB-5u68E:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v54 5-HYDROXYTRYPTAMINE
RECEPTOR 1B,OB-1
FUSED 5-HT1B
RECEPTOR,5-HYDROXYTR
YPTAMINE RECEPTOR 1B

(Spodoptera
frugiperda;
Homo sapiens) 		no annotation 5 ASP A1050
LEU A 227
ALA A 144
VAL A 142
ASP A 146
 None
 1.22A 6c2mB-5v54A:
undetectable		 6c2mB-5v54A:
22.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5wdx JFH-1 NS3

(Hepacivirus C) 		no annotation 6 VAL A  55
ASP A  81
LEU A 135
ALA A 157
VAL A 158
ASP A 168
 None
 0.41A 6c2mB-5wdxA:
27.5		 6c2mB-5wdxA:
37.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xez GLUCAGON
RECEPTOR,ENDOLYSIN,G
LUCAGON RECEPTOR

(Homo sapiens;
Escherichia
virus T4) 		PF00002
(7tm_2)
PF00959
(Phage_lysozyme)
PF02793
(HRM) 		5 VAL A 396
LEU A 153
ALA A 188
VAL A 191
SER A 190
 None
 1.36A 6c2mB-5xezA:
undetectable		 6c2mB-5xezA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xjv DUAL SPECIFICITY
PROTEIN PHOSPHATASE
13 ISOFORM A

(Homo sapiens) 		no annotation 5 VAL A  93
HIS A  72
LEU A 141
ARG A 135
ALA A 137
 None
None
None
PO4  A 201 (-3.9A)
None
 1.30A 6c2mB-5xjvA:
undetectable		 6c2mB-5xjvA:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xog RNA POLYMERASE II
THIRD LARGEST
SUBUNIT B44, PART OF
CENTRAL CORE
SPT4/5 COMPLEX
COMPONENT

(Komagataella
phaffii;
Komagataella
phaffii) 		PF01000
(RNA_pol_A_bac)
PF01193
(RNA_pol_L)
PF00467
(KOW) 		5 HIS W 783
LEU C  98
ALA C 159
SER C  95
ASP C  46
 None
 1.28A 6c2mB-5xogW:
undetectable		 6c2mB-5xogW:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y3s -

(-) 		no annotation 5 LEU A 942
ALA A 915
VAL A 917
SER A 919
ASP A 913
 None
None
None
None
PO4  A1001 (-3.9A)
 1.36A 6c2mB-5y3sA:
undetectable		 6c2mB-5y3sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykn PROBABLE
LYSINE-SPECIFIC
DEMETHYLASE JMJ14

(Arabidopsis
thaliana) 		no annotation 5 VAL A 473
LEU A 442
ARG A 469
ALA A 413
VAL A 412
 None
 1.37A 6c2mB-5yknA:
undetectable		 6c2mB-5yknA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zvs PUTATIVE CORE
PROTEIN NTPASE/VP5

(Aquareovirus C) 		no annotation 5 VAL 4 690
HIS 4 692
LEU 4 511
ALA 4 403
VAL 4 404
 None
 1.34A 6c2mB-5zvs4:
undetectable		 6c2mB-5zvs4:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c2j RNAP1
RNAP2

(Escherichia
virus N4;
Escherichia
virus N4) 		no annotation
no annotation 		5 VAL A 178
HIS A 180
ASP A 177
LEU B  39
ASP B  61
 None
 1.27A 6c2mB-6c2jA:
undetectable		 6c2mB-6c2jA:
17.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6epi ZETA_1 TOXIN

(Neisseria
gonorrhoeae) 		no annotation 5 ASP B 225
LEU B 199
ALA B 160
VAL B 161
SER B 162
 None
 1.36A 6c2mB-6epiB:
undetectable		 6c2mB-6epiB:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyd PUTATIVE
FAD-DEPENDENT
OXYGENASE ENCM

(Streptomyces
maritimus) 		no annotation 5 HIS A  83
LEU A  47
ARG A  74
ALA A  49
ASP A  93
 FAD  A 600 ( 4.7A)
None
None
None
None
 1.28A 6c2mB-6fydA:
undetectable		 6c2mB-6fydA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
9, MITOCHONDRIAL

(Mus musculus) 		no annotation 5 VAL P   5
HIS P   2
LEU P  38
ALA P  21
VAL P  91
 None
 1.35A 6c2mB-6g2jP:
undetectable		 6c2mB-6g2jP:
24.39