SIMILAR PATTERNS OF AMINO ACIDS FOR 6C06_D_FI8D1404_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bbu PROTEIN (LYSYL-TRNA
SYNTHETASE)

(Escherichia
coli) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 ILE A 491
THR A 490
THR A 486
SER A 179
 None
 1.04A 6c06C-1bbuA:
0.9		 6c06C-1bbuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1brr PROTEIN
(BACTERIORHODOPSIN)

(Halobacterium
salinarum) 		PF01036
(Bac_rhodopsin) 		4 ILE A   4
THR A   5
GLU A 204
SER A 193
 None
 1.07A 6c06C-1brrA:
0.0		 6c06C-1brrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1brr PROTEIN
(BACTERIORHODOPSIN)

(Halobacterium
salinarum) 		PF01036
(Bac_rhodopsin) 		4 ILE A   4
THR A   5
THR A 205
SER A 193
 None
 1.08A 6c06C-1brrA:
0.0		 6c06C-1brrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6h CHALCONE SYNTHASE

(Medicago sativa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ILE A 246
THR A 245
GLN A 244
THR A 169
 None
 1.02A 6c06C-1d6hA:
0.0		 6c06C-1d6hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6h CHALCONE SYNTHASE

(Medicago sativa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ILE A 246
THR A 245
THR A 169
ARG A 172
 None
 0.83A 6c06C-1d6hA:
0.0		 6c06C-1d6hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ded CYCLODEXTRIN
GLUCANOTRANSFERASE

(Bacillus sp.
1011) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		4 ILE A 246
THR A 245
GLU A 612
SER A 641
 None
 1.06A 6c06C-1dedA:
0.0		 6c06C-1dedA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ded CYCLODEXTRIN
GLUCANOTRANSFERASE

(Bacillus sp.
1011) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		4 ILE A 463
THR A 386
GLN A 389
THR A 383
 None
 1.14A 6c06C-1dedA:
0.0		 6c06C-1dedA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgp ARISTOLOCHENE
SYNTHASE

(Penicillium
roqueforti) 		no annotation 4 THR A  44
GLN A  45
THR A 296
GLU A 293
 None
 1.06A 6c06C-1dgpA:
0.0		 6c06C-1dgpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1di6 MOLYBDENUM COFACTOR
BIOSYNTHETIC ENZYME

(Escherichia
coli) 		PF00994
(MoCF_biosynth) 		4 ILE A 115
THR A 113
GLU A 141
SER A 138
 None
 1.11A 6c06C-1di6A:
0.0		 6c06C-1di6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE

(Escherichia
coli) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 ILE A 491
THR A 490
THR A 486
SER A 179
 None
 1.10A 6c06C-1e1tA:
0.0		 6c06C-1e1tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee0 2-PYRONE SYNTHASE

(Gerbera hybrid
cultivar) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ILE A 251
THR A 250
THR A 174
ARG A 177
 None
 0.95A 6c06C-1ee0A:
0.0		 6c06C-1ee0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fiq XANTHINE OXIDASE

(Bos taurus) 		PF00111
(Fer2)
PF01799
(Fer2_2) 		4 ILE A 120
THR A 117
THR A  39
GLU A  89
 None
 0.97A 6c06C-1fiqA:
0.0		 6c06C-1fiqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ko7 HPR
KINASE/PHOSPHATASE

(Staphylococcus
xylosus) 		PF02603
(Hpr_kinase_N)
PF07475
(Hpr_kinase_C) 		4 ILE A 261
THR A 260
THR A 257
GLU A 246
 None
 1.02A 6c06C-1ko7A:
undetectable		 6c06C-1ko7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1krh BENZOATE
1,2-DIOXYGENASE
REDUCTASE

(Acinetobacter
sp.) 		PF00111
(Fer2)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 ILE A 222
THR A 220
THR A 125
SER A 120
 None
FAD  A 501 (-3.2A)
None
None
 1.09A 6c06C-1krhA:
undetectable		 6c06C-1krhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m0w GLUTATHIONE
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF03199
(GSH_synthase)
PF03917
(GSH_synth_ATP) 		4 ILE A 142
THR A 352
GLN A 141
GLU A 416
 None
 1.03A 6c06C-1m0wA:
undetectable		 6c06C-1m0wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 ILE A 120
THR A 117
THR A  39
GLU A  89
 None
 0.99A 6c06C-1n5xA:
undetectable		 6c06C-1n5xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwi OSMOTICALLY
INDUCIBLE PROTEIN

(Escherichia
coli) 		PF02566
(OsmC) 		4 THR A  24
GLN A   8
THR A  21
LYS A  19
 None
 1.13A 6c06C-1qwiA:
undetectable		 6c06C-1qwiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qxo CHORISMATE SYNTHASE

(Streptococcus
pneumoniae) 		PF01264
(Chorismate_synt) 		4 GLN A  40
THR A 137
ARG A  39
SER A   9
 None
EPS  A5001 ( 4.9A)
EPS  A5001 (-2.8A)
EPS  A5001 ( 4.3A)
 1.03A 6c06C-1qxoA:
undetectable		 6c06C-1qxoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r53 CHORISMATE SYNTHASE

(Saccharomyces
cerevisiae) 		PF01264
(Chorismate_synt) 		4 ILE A 179
THR A 180
ARG A  45
GLU A 140
 None
 0.88A 6c06C-1r53A:
undetectable		 6c06C-1r53A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1udd TRANSCRIPTIONAL
REGULATOR

(Pyrococcus
horikoshii) 		PF03070
(TENA_THI-4) 		4 ILE A   5
THR A   6
GLU A  14
SER A  13
 None
 0.83A 6c06C-1uddA:
undetectable		 6c06C-1uddA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v7v CHITOBIOSE
PHOSPHORYLASE

(Vibrio
proteolyticus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 THR A 709
GLN A 324
THR A 327
SER A 336
 None
 1.14A 6c06C-1v7vA:
undetectable		 6c06C-1v7vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 ILE A  17
THR A  16
THR A 365
SER A 358
 None
 1.13A 6c06C-1wl4A:
undetectable		 6c06C-1wl4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7m HYPOTHETICAL PROTEIN
BSU14040

(Bacillus
subtilis) 		PF01476
(LysM)
PF03734
(YkuD) 		4 ILE A 162
THR A 161
THR A 158
SER A  70
 None
 0.94A 6c06C-1y7mA:
undetectable		 6c06C-1y7mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b34 MAR1 RIBONUCLEASE

(Caenorhabditis
elegans) 		PF00857
(Isochorismatase) 		4 ILE A  37
THR A  38
THR A 191
SER A 161
 None
 1.05A 6c06C-2b34A:
undetectable		 6c06C-2b34A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5v L-ASPARTATE OXIDASE

(Sulfurisphaera
tokodaii) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 ILE A  62
THR A  61
THR A 106
SER A  53
 None
 1.13A 6c06C-2e5vA:
undetectable		 6c06C-2e5vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2geb HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Caldanaerobacter
subterraneus) 		PF00156
(Pribosyltran) 		4 ILE A  81
THR A  76
GLU A 138
SER A 106
 None
 0.99A 6c06C-2gebA:
undetectable		 6c06C-2gebA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h4t CARNITINE
O-PALMITOYLTRANSFERA
SE II, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00755
(Carn_acyltransf) 		4 THR A 491
THR A 543
GLU A 487
SER A 488
 None
 1.14A 6c06C-2h4tA:
undetectable		 6c06C-2h4tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)

(Homo sapiens) 		PF03199
(GSH_synthase)
PF03917
(GSH_synth_ATP) 		4 ILE A 396
GLN A 366
THR A 100
SER A  91
 None
 0.96A 6c06C-2hgsA:
undetectable		 6c06C-2hgsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7f FERREDOXIN COMPONENT
OF DIOXYGENASE

(Sphingobium
yanoikuyae) 		PF00355
(Rieske) 		4 THR A  60
GLN A  57
GLU A  63
SER A  70
 None
 1.10A 6c06C-2i7fA:
undetectable		 6c06C-2i7fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j85 STIV B116

(Sulfolobus
turreted
icosahedral
virus 1) 		PF08960
(DUF1874) 		4 ILE A  24
THR A  23
THR A  20
GLU A  77
 None
 1.09A 6c06C-2j85A:
undetectable		 6c06C-2j85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nmp CYSTATHIONINE
GAMMA-LYASE

(Homo sapiens) 		PF01053
(Cys_Met_Meta_PP) 		4 ILE A 290
THR A 163
THR A 158
SER A 138
 None
 1.08A 6c06C-2nmpA:
0.0		 6c06C-2nmpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzg CONSERVED
UNCHARACTERIZED
ARCHAEAL PROTEIN

(Methanococcus
maripaludis) 		PF03685
(UPF0147) 		4 THR A  77
GLN A  78
GLU A  85
SER A  84
 None
 1.01A 6c06C-2qzgA:
undetectable		 6c06C-2qzgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9t ROUNDABOUT HOMOLOG 1
SLIT HOMOLOG 2
PROTEIN N-PRODUCT

(Homo sapiens;
Homo sapiens) 		PF13927
(Ig_3)
PF01462
(LRRNT)
PF01463
(LRRCT)
PF13855
(LRR_8) 		4 ILE A  70
ARG B 287
LYS B 289
SER B 280
 None
 0.99A 6c06C-2v9tA:
undetectable		 6c06C-2v9tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xd4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Bacillus
subtilis) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 THR A 293
GLN A 294
THR A 381
SER A 232
 None
 1.09A 6c06C-2xd4A:
undetectable		 6c06C-2xd4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdr BETAINE ALDEHYDE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00171
(Aldedh) 		4 ILE A  27
THR A  26
THR A  23
GLU A   6
 None
K  A1493 (-4.1A)
None
None
 1.15A 6c06C-2xdrA:
undetectable		 6c06C-2xdrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5r BENZALACETONE
SYNTHASE

(Rheum palmatum) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ILE A 239
THR A 238
THR A 162
ARG A 165
 None
 0.85A 6c06C-3a5rA:
0.0		 6c06C-3a5rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3amj ZINC PEPTIDASE
INACTIVE SUBUNIT

(Sphingomonas
sp. A1) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 ILE B 226
THR B 225
GLN B 229
SER B  31
 None
 1.13A 6c06C-3amjB:
undetectable		 6c06C-3amjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3be7 ZN-DEPENDENT
ARGININE
CARBOXYPEPTIDASE

(unidentified) 		PF01979
(Amidohydro_1) 		4 ILE A 347
THR A 346
THR A 101
SER A  61
 None
 1.02A 6c06C-3be7A:
undetectable		 6c06C-3be7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bt6 INFLUENZA B
HEMAGGLUTININ (HA)

(Influenza B
virus) 		PF00509
(Hemagglutinin) 		4 ILE B  48
THR B  49
GLU B  57
SER B  56
 None
 0.82A 6c06C-3bt6B:
undetectable		 6c06C-3bt6B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwm 9.5 KDA CULTURE
FILTRATE ANTIGEN
CFP10A

(Mycobacterium
tuberculosis) 		PF02597
(ThiS) 		4 ILE A  10
THR A   9
THR A  15
SER A   6
 None
 1.11A 6c06C-3dwmA:
undetectable		 6c06C-3dwmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3esl CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1

(Saccharomyces
cerevisiae) 		PF08311
(Mad3_BUB1_I) 		4 ILE A  41
THR A  87
ARG A  90
SER A  79
 None
 0.97A 6c06C-3eslA:
undetectable		 6c06C-3eslA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		4 THR A 343
THR A 353
LYS A 554
SER A 349
 None
 1.12A 6c06C-3fahA:
undetectable		 6c06C-3fahA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fc7 HTR-LIKE PROTEIN

(Haloarcula
marismortui) 		PF08448
(PAS_4) 		4 ILE A 222
ARG A 238
GLU A 209
SER A 208
 None
 1.14A 6c06C-3fc7A:
undetectable		 6c06C-3fc7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fge PUTATIVE FLAVIN
REDUCTASE WITH SPLIT
BARREL DOMAIN

(Shewanella
frigidimarina) 		PF01613
(Flavin_Reduct) 		4 ILE A  84
THR A  83
THR A  72
GLU A 108
 None
 1.10A 6c06C-3fgeA:
undetectable		 6c06C-3fgeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440

(Streptococcus
pneumoniae) 		PF03644
(Glyco_hydro_85) 		4 THR A 760
THR A 755
LYS A 549
SER A 557
 None
 1.07A 6c06C-3gdbA:
undetectable		 6c06C-3gdbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihs PHOSPHOCARRIER
PROTEIN HPR

(Bacillus
anthracis) 		PF00381
(PTS-HPr) 		4 ILE A  61
THR A  62
THR A  65
GLU A  71
 None
 1.10A 6c06C-3ihsA:
undetectable		 6c06C-3ihsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9t V-TYPE PROTON ATPASE
SUBUNIT F

(Saccharomyces
cerevisiae) 		PF01990
(ATP-synt_F) 		4 ILE N  50
THR N  51
THR N  58
SER N  83
 None
 1.04A 6c06C-3j9tN:
undetectable		 6c06C-3j9tN:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l9v PUTATIVE
THIOL-DISULFIDE
ISOMERASE OR
THIOREDOXIN

(Salmonella
enterica) 		PF01323
(DSBA) 		4 ILE A  84
THR A  81
ARG A  44
GLU A  21
 None
 1.03A 6c06C-3l9vA:
undetectable		 6c06C-3l9vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpg DIHYDROOROTASE

(Bacillus
anthracis) 		PF01979
(Amidohydro_1) 		4 ILE A 324
THR A 325
ARG A  63
GLU A 312
 None
 1.02A 6c06C-3mpgA:
undetectable		 6c06C-3mpgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3noy 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE

(Aquifex
aeolicus) 		PF04551
(GcpE) 		4 THR A   7
THR A 169
LYS A 121
GLU A 164
 None
 1.10A 6c06C-3noyA:
undetectable		 6c06C-3noyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvy XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF00111
(Fer2)
PF01799
(Fer2_2) 		4 ILE A 120
THR A 117
THR A  39
GLU A  89
 None
 1.00A 6c06C-3nvyA:
undetectable		 6c06C-3nvyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3se5 CELL FILAMENTATION
PROTEIN FIC-RELATED
PROTEIN

(Neisseria
meningitidis) 		PF02661
(Fic) 		4 ILE A  60
GLN A  43
ARG A  47
SER A 116
 None
 1.12A 6c06C-3se5A:
undetectable		 6c06C-3se5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uj2 ENOLASE 1

(Anaerostipes
caccae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 GLN A 301
ARG A 305
GLU A 270
SER A 269
 None
 0.94A 6c06C-3uj2A:
undetectable		 6c06C-3uj2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9f TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE/RESPONSE
REGULATOR, HYBRID
(ONE-COMPONENT
SYSTEM)

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		4 ILE A  66
THR A  67
GLU A  71
SER A  79
 None
 1.06A 6c06C-3v9fA:
undetectable		 6c06C-3v9fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vth HYDROGENASE
MATURATION FACTOR

(Caldanaerobacter
subterraneus) 		PF00708
(Acylphosphatase)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		4 ILE A 504
ARG A 379
GLU A 494
SER A 490
 None
 1.15A 6c06C-3vthA:
undetectable		 6c06C-3vthA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23

(Clostridium
botulinum;
Homo sapiens) 		PF01742
(Peptidase_M27)
PF07952
(Toxin_trans) 		4 ILE A 130
THR A 132
LYS A  37
SER A 146
 None
 1.12A 6c06C-3zusA:
undetectable		 6c06C-3zusA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eh1 FLAVOHEMOPROTEIN

(Vibrio cholerae) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 THR A 128
GLN A 131
ARG A  70
SER A  16
 FAD  A 301 (-3.2A)
None
None
None
 1.12A 6c06C-4eh1A:
0.8		 6c06C-4eh1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1

(Caenorhabditis
elegans) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 ILE A 282
THR A 281
THR A1163
LYS A1223
 None
 1.07A 6c06C-4f4cA:
undetectable		 6c06C-4f4cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f62 GERANYLTRANSTRANSFER
ASE

(Marinomonas sp.
MED121) 		PF00348
(polyprenyl_synt) 		4 ILE A 152
GLN A 155
GLU A 162
SER A 160
 None
 1.08A 6c06C-4f62A:
undetectable		 6c06C-4f62A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ijn ACETATE KINASE

(Mycolicibacterium
smegmatis) 		PF00871
(Acetate_kinase) 		4 ILE A 174
GLN A 171
THR A 363
SER A 307
 None
 1.02A 6c06C-4ijnA:
undetectable		 6c06C-4ijnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ix9 V-TYPE PROTON ATPASE
SUBUNIT F

(Saccharomyces
cerevisiae) 		PF01990
(ATP-synt_F) 		4 ILE A  50
THR A  51
THR A  58
SER A  83
 None
 1.09A 6c06C-4ix9A:
undetectable		 6c06C-4ix9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l63 ECXA

(Escherichia
coli) 		PF16313
(DUF4953) 		4 ILE A 126
THR A 125
THR A 115
SER A 121
 None
 0.95A 6c06C-4l63A:
undetectable		 6c06C-4l63A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lm8 EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT MTRC

(Shewanella
oneidensis) 		PF14522
(Cytochrome_C7) 		4 ILE A 610
THR A 611
THR A 616
ARG A 553
 None
HEC  A 810 (-3.9A)
None
None
 1.13A 6c06C-4lm8A:
undetectable		 6c06C-4lm8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 ILE A  43
THR A  44
THR A1208
SER A  47
 None
 1.13A 6c06C-4o9xA:
undetectable		 6c06C-4o9xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opm LIPASE

(Acinetobacter
baumannii) 		PF12697
(Abhydrolase_6) 		4 ILE A  36
THR A  35
GLN A  39
SER A  48
 None
 1.09A 6c06C-4opmA:
undetectable		 6c06C-4opmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w7g DYNEIN LIGHT
INTERMEDIATE CHAIN

(Chaetomium
thermophilum) 		PF05783
(DLIC) 		4 ILE A 142
THR A 271
GLU A  62
SER A  59
 None
 0.87A 6c06C-4w7gA:
undetectable		 6c06C-4w7gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wgk NEUTRAL CERAMIDASE

(Homo sapiens) 		PF04734
(Ceramidase_alk)
PF17048
(Ceramidse_alk_C) 		4 ILE A 255
THR A 543
GLU A 585
SER A 261
 None
 1.12A 6c06C-4wgkA:
undetectable		 6c06C-4wgkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wum CHALCONE SYNTHASE

(Freesia hybrid
cultivar) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ILE A 246
THR A 245
GLN A 244
THR A 169
 None
 1.10A 6c06C-4wumA:
undetectable		 6c06C-4wumA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wum CHALCONE SYNTHASE

(Freesia hybrid
cultivar) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ILE A 246
THR A 245
THR A 169
ARG A 172
 None
 0.92A 6c06C-4wumA:
undetectable		 6c06C-4wumA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xv0 BETA-XYLANASE

(Trichoderma
reesei) 		PF00331
(Glyco_hydro_10) 		4 ILE A 342
THR A 294
THR A 263
SER A 302
 None
 0.94A 6c06C-4xv0A:
undetectable		 6c06C-4xv0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yis MEGANUCLEASE I-CPAMI

(Cryphonectria
parasitica) 		PF00961
(LAGLIDADG_1) 		4 THR A  97
GLN A 100
THR A 104
LYS A 108
 None
 1.15A 6c06C-4yisA:
undetectable		 6c06C-4yisA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yjy CHALCONE SYNTHASE 1

(Oryza sativa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ILE A 249
THR A 248
THR A 172
ARG A 175
 None
 0.85A 6c06C-4yjyA:
undetectable		 6c06C-4yjyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 ILE A 119
THR A 116
THR A  39
GLU A  89
 None
 1.09A 6c06C-4yswA:
undetectable		 6c06C-4yswA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgv FERREDOXIN RECEPTOR

(Pectobacterium
atrosepticum) 		PF07715
(Plug) 		4 ILE A 678
THR A 630
THR A 633
GLU A 674
 None
 1.15A 6c06C-4zgvA:
undetectable		 6c06C-4zgvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoq INTRACELLULAR SERINE
PROTEASE

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		4 ILE I 203
THR I 202
GLU I 139
SER I 391
 None
 1.12A 6c06C-4zoqI:
undetectable		 6c06C-4zoqI:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amq RNA POLYMERASE L

(California
encephalitis
orthobunyavirus) 		PF04196
(Bunya_RdRp)
PF15518
(L_protein_N) 		4 ILE A 442
THR A 678
THR A 642
SER A 955
 None
None
A  C   4 ( 3.5A)
None
 1.05A 6c06C-5amqA:
undetectable		 6c06C-5amqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5diy HYALURONIDASE

(Thermobaculum
terrenum) 		PF07555
(NAGidase) 		4 ILE A 391
THR A 392
THR A 398
GLU A 410
 None
 0.82A 6c06C-5diyA:
undetectable		 6c06C-5diyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3t PHOSPHATIDYLINOSITOL
-4-PHOSPHATE
5-KINASE, TYPE I,
ALPHA

(Danio rerio) 		PF01504
(PIP5K) 		4 ILE A 169
ARG A 227
GLU A 145
SER A 141
 ANP  A 501 (-4.5A)
None
None
None
 1.08A 6c06C-5e3tA:
undetectable		 6c06C-5e3tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erb POLYKETIDE SYNTHASE

(Bacillus
amyloliquefaciens) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 ILE A 330
THR A 331
GLU A 339
SER A 338
 None
 0.96A 6c06C-5erbA:
undetectable		 6c06C-5erbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fg0 E3 UBIQUITIN-PROTEIN
LIGASE LISTERIN

(Saccharomyces
cerevisiae) 		no annotation 4 ILE A 106
GLN A 109
GLU A 154
SER A 151
 None
 0.83A 6c06C-5fg0A:
undetectable		 6c06C-5fg0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k4p PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1

(Escherichia
coli) 		PF00884
(Sulfatase) 		4 ILE A 220
THR A 219
THR A 315
ARG A 318
 None
 1.14A 6c06C-5k4pA:
undetectable		 6c06C-5k4pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l5g PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		4 ILE A 860
THR A 861
GLN A 859
SER A 810
 None
 1.07A 6c06C-5l5gA:
undetectable		 6c06C-5l5gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lm7 TRANSCRIPTION
TERMINATION/ANTITERM
INATION PROTEIN NUSA

(Escherichia
coli) 		PF00575
(S1)
PF08529
(NusA_N)
PF13184
(KH_5) 		4 THR A 109
GLN A 108
ARG A 104
GLU A   4
 None
 0.83A 6c06C-5lm7A:
undetectable		 6c06C-5lm7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mxf PHOTORHABDUS
ASYMBIOTICA LECTIN
PHL

(Photorhabdus
asymbiotica) 		PF03984
(DUF346) 		4 ILE A 253
THR A 252
THR A 230
LYS A 277
 None
 1.10A 6c06C-5mxfA:
undetectable		 6c06C-5mxfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o1p ALPHA-AMINOADIPIC
SEMIALDEHYDE
SYNTHASE,
MITOCHONDRIAL

(Homo sapiens) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		4 THR A 855
LYS A 912
GLU A 614
SER A 615
 None
 1.12A 6c06C-5o1pA:
undetectable		 6c06C-5o1pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opz CHIX

(Serratia
marcescens) 		no annotation 4 ILE A   9
ARG A  35
GLU A  16
SER A  15
 None
 1.00A 6c06C-5opzA:
undetectable		 6c06C-5opzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		4 ILE C1043
THR C1044
THR C1087
ARG C1090
 None
 0.93A 6c06C-5tw1C:
32.9		 6c06C-5tw1C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		4 THR C1044
GLN C1045
THR C1087
ARG C1090
 None
 1.05A 6c06C-5tw1C:
32.9		 6c06C-5tw1C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uc5 CHS2 CHALCONE
SYNTHASE

(Malus domestica) 		no annotation 4 ILE A 246
THR A 245
THR A 169
ARG A 172
 None
 0.85A 6c06C-5uc5A:
undetectable		 6c06C-5uc5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uco 2,4,6-TRIHYDROXYBENZ
OPHENONE SYNTHASE

(Hypericum
androsaemum) 		no annotation 4 ILE A 250
THR A 249
THR A 172
ARG A 175
 None
 0.94A 6c06C-5ucoA:
undetectable		 6c06C-5ucoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uxn PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE

(Pseudomonas
aeruginosa) 		no annotation 4 ILE A 356
THR A 355
ARG A 320
SER A 118
 None
None
PEP  A 504 (-3.9A)
PO4  A 502 (-2.4A)
 1.03A 6c06C-5uxnA:
undetectable		 6c06C-5uxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1

(Streptococcus
gordonii) 		no annotation 4 ILE A 416
GLN A 328
GLU A 333
SER A 332
 None
 1.07A 6c06C-5vaeA:
undetectable		 6c06C-5vaeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vmn BAK PROTEIN

(Singapore
grouper
iridovirus) 		no annotation 4 ILE A  89
THR A  90
GLN A  92
ARG A  95
 None
NO3  A 205 ( 4.9A)
None
None
 1.06A 6c06C-5vmnA:
undetectable		 6c06C-5vmnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		4 ILE A 381
THR A 382
THR A 562
SER A 472
 None
 1.15A 6c06C-5vocA:
2.1		 6c06C-5vocA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9w DNA MISMATCH REPAIR
PROTEIN MUTS

(Neisseria
gonorrhoeae) 		no annotation 4 ILE A 317
GLN A 321
THR A 325
SER A 382
 None
 0.97A 6c06C-5x9wA:
undetectable		 6c06C-5x9wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgu RIBONUCLEASE R

(Escherichia
coli) 		no annotation 4 THR B 364
GLN B 365
THR B 298
GLU B 188
 None
 0.91A 6c06C-5xguB:
2.4		 6c06C-5xguB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnu PUTATIVE INTEGRAL
MEMBRANE PROTEIN

(Escherichia
coli) 		no annotation 4 ILE A 218
THR A 217
THR A 313
ARG A 316
 None
 1.08A 6c06C-5xnuA:
undetectable		 6c06C-5xnuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xw6 P2X PURINOCEPTOR

(Gallus gallus) 		no annotation 4 ILE C 196
GLN C 194
THR C 192
SER C  59
 None
 1.02A 6c06C-5xw6C:
undetectable		 6c06C-5xw6C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfu SPIKE PROTEIN

(Coronavirus
HKU15) 		no annotation 4 ILE A 501
THR A 507
GLU A 485
SER A 287
 None
 0.94A 6c06C-6bfuA:
0.0		 6c06C-6bfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co0 STYRYLPYRONE
SYNTHASE 1

(Piper
methysticum) 		no annotation 4 ILE A 247
THR A 246
THR A 169
ARG A 172
 None
 0.76A 6c06C-6co0A:
undetectable		 6c06C-6co0A:
undetectable