SIMILAR PATTERNS OF AMINO ACIDS FOR 6C06_D_FI8D1404

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bbu PROTEIN (LYSYL-TRNA
SYNTHETASE)

(Escherichia
coli) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 ILE A 491
THR A 490
THR A 486
SER A 179
 None
 1.04A 6c06C-1bbuA:
0.9		 6c06C-1bbuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1brr PROTEIN
(BACTERIORHODOPSIN)

(Halobacterium
salinarum) 		PF01036
(Bac_rhodopsin) 		4 ILE A   4
THR A   5
GLU A 204
SER A 193
 None
 1.07A 6c06C-1brrA:
0.0		 6c06C-1brrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1brr PROTEIN
(BACTERIORHODOPSIN)

(Halobacterium
salinarum) 		PF01036
(Bac_rhodopsin) 		4 ILE A   4
THR A   5
THR A 205
SER A 193
 None
 1.08A 6c06C-1brrA:
0.0		 6c06C-1brrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6h CHALCONE SYNTHASE

(Medicago sativa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ILE A 246
THR A 245
GLN A 244
THR A 169
 None
 1.02A 6c06C-1d6hA:
0.0		 6c06C-1d6hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6h CHALCONE SYNTHASE

(Medicago sativa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ILE A 246
THR A 245
THR A 169
ARG A 172
 None
 0.83A 6c06C-1d6hA:
0.0		 6c06C-1d6hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ded CYCLODEXTRIN
GLUCANOTRANSFERASE

(Bacillus sp.
1011) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		4 ILE A 246
THR A 245
GLU A 612
SER A 641
 None
 1.06A 6c06C-1dedA:
0.0		 6c06C-1dedA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ded CYCLODEXTRIN
GLUCANOTRANSFERASE

(Bacillus sp.
1011) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		4 ILE A 463
THR A 386
GLN A 389
THR A 383
 None
 1.14A 6c06C-1dedA:
0.0		 6c06C-1dedA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dgp ARISTOLOCHENE
SYNTHASE

(Penicillium
roqueforti) 		no annotation 4 THR A  44
GLN A  45
THR A 296
GLU A 293
 None
 1.06A 6c06C-1dgpA:
0.0		 6c06C-1dgpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1di6 MOLYBDENUM COFACTOR
BIOSYNTHETIC ENZYME

(Escherichia
coli) 		PF00994
(MoCF_biosynth) 		4 ILE A 115
THR A 113
GLU A 141
SER A 138
 None
 1.11A 6c06C-1di6A:
0.0		 6c06C-1di6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e1t LYSYL-TRNA
SYNTHETASE, HEAT
INDUCIBLE

(Escherichia
coli) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		4 ILE A 491
THR A 490
THR A 486
SER A 179
 None
 1.10A 6c06C-1e1tA:
0.0		 6c06C-1e1tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee0 2-PYRONE SYNTHASE

(Gerbera hybrid
cultivar) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ILE A 251
THR A 250
THR A 174
ARG A 177
 None
 0.95A 6c06C-1ee0A:
0.0		 6c06C-1ee0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fiq XANTHINE OXIDASE

(Bos taurus) 		PF00111
(Fer2)
PF01799
(Fer2_2) 		4 ILE A 120
THR A 117
THR A  39
GLU A  89
 None
 0.97A 6c06C-1fiqA:
0.0		 6c06C-1fiqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ko7 HPR
KINASE/PHOSPHATASE

(Staphylococcus
xylosus) 		PF02603
(Hpr_kinase_N)
PF07475
(Hpr_kinase_C) 		4 ILE A 261
THR A 260
THR A 257
GLU A 246
 None
 1.02A 6c06C-1ko7A:
undetectable		 6c06C-1ko7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1krh BENZOATE
1,2-DIOXYGENASE
REDUCTASE

(Acinetobacter
sp.) 		PF00111
(Fer2)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 ILE A 222
THR A 220
THR A 125
SER A 120
 None
FAD  A 501 (-3.2A)
None
None
 1.09A 6c06C-1krhA:
undetectable		 6c06C-1krhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m0w GLUTATHIONE
SYNTHETASE

(Saccharomyces
cerevisiae) 		PF03199
(GSH_synthase)
PF03917
(GSH_synth_ATP) 		4 ILE A 142
THR A 352
GLN A 141
GLU A 416
 None
 1.03A 6c06C-1m0wA:
undetectable		 6c06C-1m0wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1n5x XANTHINE
DEHYDROGENASE

(Bos taurus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 ILE A 120
THR A 117
THR A  39
GLU A  89
 None
 0.99A 6c06C-1n5xA:
undetectable		 6c06C-1n5xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qwi OSMOTICALLY
INDUCIBLE PROTEIN

(Escherichia
coli) 		PF02566
(OsmC) 		4 THR A  24
GLN A   8
THR A  21
LYS A  19
 None
 1.13A 6c06C-1qwiA:
undetectable		 6c06C-1qwiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qxo CHORISMATE SYNTHASE

(Streptococcus
pneumoniae) 		PF01264
(Chorismate_synt) 		4 GLN A  40
THR A 137
ARG A  39
SER A   9
 None
EPS  A5001 ( 4.9A)
EPS  A5001 (-2.8A)
EPS  A5001 ( 4.3A)
 1.03A 6c06C-1qxoA:
undetectable		 6c06C-1qxoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r53 CHORISMATE SYNTHASE

(Saccharomyces
cerevisiae) 		PF01264
(Chorismate_synt) 		4 ILE A 179
THR A 180
ARG A  45
GLU A 140
 None
 0.88A 6c06C-1r53A:
undetectable		 6c06C-1r53A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1udd TRANSCRIPTIONAL
REGULATOR

(Pyrococcus
horikoshii) 		PF03070
(TENA_THI-4) 		4 ILE A   5
THR A   6
GLU A  14
SER A  13
 None
 0.83A 6c06C-1uddA:
undetectable		 6c06C-1uddA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v7v CHITOBIOSE
PHOSPHORYLASE

(Vibrio
proteolyticus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 THR A 709
GLN A 324
THR A 327
SER A 336
 None
 1.14A 6c06C-1v7vA:
undetectable		 6c06C-1v7vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 ILE A  17
THR A  16
THR A 365
SER A 358
 None
 1.13A 6c06C-1wl4A:
undetectable		 6c06C-1wl4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7m HYPOTHETICAL PROTEIN
BSU14040

(Bacillus
subtilis) 		PF01476
(LysM)
PF03734
(YkuD) 		4 ILE A 162
THR A 161
THR A 158
SER A  70
 None
 0.94A 6c06C-1y7mA:
undetectable		 6c06C-1y7mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b34 MAR1 RIBONUCLEASE

(Caenorhabditis
elegans) 		PF00857
(Isochorismatase) 		4 ILE A  37
THR A  38
THR A 191
SER A 161
 None
 1.05A 6c06C-2b34A:
undetectable		 6c06C-2b34A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e5v L-ASPARTATE OXIDASE

(Sulfurisphaera
tokodaii) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		4 ILE A  62
THR A  61
THR A 106
SER A  53
 None
 1.13A 6c06C-2e5vA:
undetectable		 6c06C-2e5vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2geb HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Caldanaerobacter
subterraneus) 		PF00156
(Pribosyltran) 		4 ILE A  81
THR A  76
GLU A 138
SER A 106
 None
 0.99A 6c06C-2gebA:
undetectable		 6c06C-2gebA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h4t CARNITINE
O-PALMITOYLTRANSFERA
SE II, MITOCHONDRIAL

(Rattus
norvegicus) 		PF00755
(Carn_acyltransf) 		4 THR A 491
THR A 543
GLU A 487
SER A 488
 None
 1.14A 6c06C-2h4tA:
undetectable		 6c06C-2h4tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)

(Homo sapiens) 		PF03199
(GSH_synthase)
PF03917
(GSH_synth_ATP) 		4 ILE A 396
GLN A 366
THR A 100
SER A  91
 None
 0.96A 6c06C-2hgsA:
undetectable		 6c06C-2hgsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i7f FERREDOXIN COMPONENT
OF DIOXYGENASE

(Sphingobium
yanoikuyae) 		PF00355
(Rieske) 		4 THR A  60
GLN A  57
GLU A  63
SER A  70
 None
 1.10A 6c06C-2i7fA:
undetectable		 6c06C-2i7fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j85 STIV B116

(Sulfolobus
turreted
icosahedral
virus 1) 		PF08960
(DUF1874) 		4 ILE A  24
THR A  23
THR A  20
GLU A  77
 None
 1.09A 6c06C-2j85A:
undetectable		 6c06C-2j85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nmp CYSTATHIONINE
GAMMA-LYASE

(Homo sapiens) 		PF01053
(Cys_Met_Meta_PP) 		4 ILE A 290
THR A 163
THR A 158
SER A 138
 None
 1.08A 6c06C-2nmpA:
0.0		 6c06C-2nmpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qzg CONSERVED
UNCHARACTERIZED
ARCHAEAL PROTEIN

(Methanococcus
maripaludis) 		PF03685
(UPF0147) 		4 THR A  77
GLN A  78
GLU A  85
SER A  84
 None
 1.01A 6c06C-2qzgA:
undetectable		 6c06C-2qzgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9t ROUNDABOUT HOMOLOG 1
SLIT HOMOLOG 2
PROTEIN N-PRODUCT

(Homo sapiens;
Homo sapiens) 		PF13927
(Ig_3)
PF01462
(LRRNT)
PF01463
(LRRCT)
PF13855
(LRR_8) 		4 ILE A  70
ARG B 287
LYS B 289
SER B 280
 None
 0.99A 6c06C-2v9tA:
undetectable		 6c06C-2v9tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xd4 PHOSPHORIBOSYLAMINE-
-GLYCINE LIGASE

(Bacillus
subtilis) 		PF01071
(GARS_A)
PF02843
(GARS_C)
PF02844
(GARS_N) 		4 THR A 293
GLN A 294
THR A 381
SER A 232
 None
 1.09A 6c06C-2xd4A:
undetectable		 6c06C-2xd4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdr BETAINE ALDEHYDE
DEHYDROGENASE

(Pseudomonas
aeruginosa) 		PF00171
(Aldedh) 		4 ILE A  27
THR A  26
THR A  23
GLU A   6
 None
K  A1493 (-4.1A)
None
None
 1.15A 6c06C-2xdrA:
undetectable		 6c06C-2xdrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5r BENZALACETONE
SYNTHASE

(Rheum palmatum) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ILE A 239
THR A 238
THR A 162
ARG A 165
 None
 0.85A 6c06C-3a5rA:
0.0		 6c06C-3a5rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3amj ZINC PEPTIDASE
INACTIVE SUBUNIT

(Sphingomonas
sp. A1) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		4 ILE B 226
THR B 225
GLN B 229
SER B  31
 None
 1.13A 6c06C-3amjB:
undetectable		 6c06C-3amjB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3be7 ZN-DEPENDENT
ARGININE
CARBOXYPEPTIDASE

(unidentified) 		PF01979
(Amidohydro_1) 		4 ILE A 347
THR A 346
THR A 101
SER A  61
 None
 1.02A 6c06C-3be7A:
undetectable		 6c06C-3be7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bt6 INFLUENZA B
HEMAGGLUTININ (HA)

(Influenza B
virus) 		PF00509
(Hemagglutinin) 		4 ILE B  48
THR B  49
GLU B  57
SER B  56
 None
 0.82A 6c06C-3bt6B:
undetectable		 6c06C-3bt6B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dwm 9.5 KDA CULTURE
FILTRATE ANTIGEN
CFP10A

(Mycobacterium
tuberculosis) 		PF02597
(ThiS) 		4 ILE A  10
THR A   9
THR A  15
SER A   6
 None
 1.11A 6c06C-3dwmA:
undetectable		 6c06C-3dwmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3esl CHECKPOINT
SERINE/THREONINE-PRO
TEIN KINASE BUB1

(Saccharomyces
cerevisiae) 		PF08311
(Mad3_BUB1_I) 		4 ILE A  41
THR A  87
ARG A  90
SER A  79
 None
 0.97A 6c06C-3eslA:
undetectable		 6c06C-3eslA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		4 THR A 343
THR A 353
LYS A 554
SER A 349
 None
 1.12A 6c06C-3fahA:
undetectable		 6c06C-3fahA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fc7 HTR-LIKE PROTEIN

(Haloarcula
marismortui) 		PF08448
(PAS_4) 		4 ILE A 222
ARG A 238
GLU A 209
SER A 208
 None
 1.14A 6c06C-3fc7A:
undetectable		 6c06C-3fc7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fge PUTATIVE FLAVIN
REDUCTASE WITH SPLIT
BARREL DOMAIN

(Shewanella
frigidimarina) 		PF01613
(Flavin_Reduct) 		4 ILE A  84
THR A  83
THR A  72
GLU A 108
 None
 1.10A 6c06C-3fgeA:
undetectable		 6c06C-3fgeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdb PUTATIVE
UNCHARACTERIZED
PROTEIN SPR0440

(Streptococcus
pneumoniae) 		PF03644
(Glyco_hydro_85) 		4 THR A 760
THR A 755
LYS A 549
SER A 557
 None
 1.07A 6c06C-3gdbA:
undetectable		 6c06C-3gdbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihs PHOSPHOCARRIER
PROTEIN HPR

(Bacillus
anthracis) 		PF00381
(PTS-HPr) 		4 ILE A  61
THR A  62
THR A  65
GLU A  71
 None
 1.10A 6c06C-3ihsA:
undetectable		 6c06C-3ihsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9t V-TYPE PROTON ATPASE
SUBUNIT F

(Saccharomyces
cerevisiae) 		PF01990
(ATP-synt_F) 		4 ILE N  50
THR N  51
THR N  58
SER N  83
 None
 1.04A 6c06C-3j9tN:
undetectable		 6c06C-3j9tN:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l9v PUTATIVE
THIOL-DISULFIDE
ISOMERASE OR
THIOREDOXIN

(Salmonella
enterica) 		PF01323
(DSBA) 		4 ILE A  84
THR A  81
ARG A  44
GLU A  21
 None
 1.03A 6c06C-3l9vA:
undetectable		 6c06C-3l9vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mpg DIHYDROOROTASE

(Bacillus
anthracis) 		PF01979
(Amidohydro_1) 		4 ILE A 324
THR A 325
ARG A  63
GLU A 312
 None
 1.02A 6c06C-3mpgA:
undetectable		 6c06C-3mpgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3noy 4-HYDROXY-3-METHYLBU
T-2-EN-1-YL
DIPHOSPHATE SYNTHASE

(Aquifex
aeolicus) 		PF04551
(GcpE) 		4 THR A   7
THR A 169
LYS A 121
GLU A 164
 None
 1.10A 6c06C-3noyA:
undetectable		 6c06C-3noyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nvy XANTHINE
DEHYDROGENASE/OXIDAS
E

(Bos taurus) 		PF00111
(Fer2)
PF01799
(Fer2_2) 		4 ILE A 120
THR A 117
THR A  39
GLU A  89
 None
 1.00A 6c06C-3nvyA:
undetectable		 6c06C-3nvyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3se5 CELL FILAMENTATION
PROTEIN FIC-RELATED
PROTEIN

(Neisseria
meningitidis) 		PF02661
(Fic) 		4 ILE A  60
GLN A  43
ARG A  47
SER A 116
 None
 1.12A 6c06C-3se5A:
undetectable		 6c06C-3se5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uj2 ENOLASE 1

(Anaerostipes
caccae) 		PF00113
(Enolase_C)
PF03952
(Enolase_N) 		4 GLN A 301
ARG A 305
GLU A 270
SER A 269
 None
 0.94A 6c06C-3uj2A:
undetectable		 6c06C-3uj2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9f TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE/RESPONSE
REGULATOR, HYBRID
(ONE-COMPONENT
SYSTEM)

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		4 ILE A  66
THR A  67
GLU A  71
SER A  79
 None
 1.06A 6c06C-3v9fA:
undetectable		 6c06C-3v9fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vth HYDROGENASE
MATURATION FACTOR

(Caldanaerobacter
subterraneus) 		PF00708
(Acylphosphatase)
PF01300
(Sua5_yciO_yrdC)
PF07503
(zf-HYPF) 		4 ILE A 504
ARG A 379
GLU A 494
SER A 490
 None
 1.15A 6c06C-3vthA:
undetectable		 6c06C-3vthA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zus BOTULINUM NEUROTOXIN
TYPE A,
SYNAPTOSOMAL-ASSOCIA
TED PROTEIN 23

(Clostridium
botulinum;
Homo sapiens) 		PF01742
(Peptidase_M27)
PF07952
(Toxin_trans) 		4 ILE A 130
THR A 132
LYS A  37
SER A 146
 None
 1.12A 6c06C-3zusA:
undetectable		 6c06C-3zusA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eh1 FLAVOHEMOPROTEIN

(Vibrio cholerae) 		PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 THR A 128
GLN A 131
ARG A  70
SER A  16
 FAD  A 301 (-3.2A)
None
None
None
 1.12A 6c06C-4eh1A:
0.8		 6c06C-4eh1A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f4c MULTIDRUG RESISTANCE
PROTEIN PGP-1

(Caenorhabditis
elegans) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		4 ILE A 282
THR A 281
THR A1163
LYS A1223
 None
 1.07A 6c06C-4f4cA:
undetectable		 6c06C-4f4cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f62 GERANYLTRANSTRANSFER
ASE

(Marinomonas sp.
MED121) 		PF00348
(polyprenyl_synt) 		4 ILE A 152
GLN A 155
GLU A 162
SER A 160
 None
 1.08A 6c06C-4f62A:
undetectable		 6c06C-4f62A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ijn ACETATE KINASE

(Mycolicibacterium
smegmatis) 		PF00871
(Acetate_kinase) 		4 ILE A 174
GLN A 171
THR A 363
SER A 307
 None
 1.02A 6c06C-4ijnA:
undetectable		 6c06C-4ijnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ix9 V-TYPE PROTON ATPASE
SUBUNIT F

(Saccharomyces
cerevisiae) 		PF01990
(ATP-synt_F) 		4 ILE A  50
THR A  51
THR A  58
SER A  83
 None
 1.09A 6c06C-4ix9A:
undetectable		 6c06C-4ix9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l63 ECXA

(Escherichia
coli) 		PF16313
(DUF4953) 		4 ILE A 126
THR A 125
THR A 115
SER A 121
 None
 0.95A 6c06C-4l63A:
undetectable		 6c06C-4l63A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lm8 EXTRACELLULAR IRON
OXIDE RESPIRATORY
SYSTEM SURFACE
DECAHEME CYTOCHROME
C COMPONENT MTRC

(Shewanella
oneidensis) 		PF14522
(Cytochrome_C7) 		4 ILE A 610
THR A 611
THR A 616
ARG A 553
 None
HEC  A 810 (-3.9A)
None
None
 1.13A 6c06C-4lm8A:
undetectable		 6c06C-4lm8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9x TCDB2, TCCC3

(Photorhabdus
luminescens) 		PF03534
(SpvB)
PF12255
(TcdB_toxin_midC)
PF12256
(TcdB_toxin_midN) 		4 ILE A  43
THR A  44
THR A1208
SER A  47
 None
 1.13A 6c06C-4o9xA:
undetectable		 6c06C-4o9xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4opm LIPASE

(Acinetobacter
baumannii) 		PF12697
(Abhydrolase_6) 		4 ILE A  36
THR A  35
GLN A  39
SER A  48
 None
 1.09A 6c06C-4opmA:
undetectable		 6c06C-4opmA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w7g DYNEIN LIGHT
INTERMEDIATE CHAIN

(Chaetomium
thermophilum) 		PF05783
(DLIC) 		4 ILE A 142
THR A 271
GLU A  62
SER A  59
 None
 0.87A 6c06C-4w7gA:
undetectable		 6c06C-4w7gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wgk NEUTRAL CERAMIDASE

(Homo sapiens) 		PF04734
(Ceramidase_alk)
PF17048
(Ceramidse_alk_C) 		4 ILE A 255
THR A 543
GLU A 585
SER A 261
 None
 1.12A 6c06C-4wgkA:
undetectable		 6c06C-4wgkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wum CHALCONE SYNTHASE

(Freesia hybrid
cultivar) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ILE A 246
THR A 245
GLN A 244
THR A 169
 None
 1.10A 6c06C-4wumA:
undetectable		 6c06C-4wumA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wum CHALCONE SYNTHASE

(Freesia hybrid
cultivar) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ILE A 246
THR A 245
THR A 169
ARG A 172
 None
 0.92A 6c06C-4wumA:
undetectable		 6c06C-4wumA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xv0 BETA-XYLANASE

(Trichoderma
reesei) 		PF00331
(Glyco_hydro_10) 		4 ILE A 342
THR A 294
THR A 263
SER A 302
 None
 0.94A 6c06C-4xv0A:
undetectable		 6c06C-4xv0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yis MEGANUCLEASE I-CPAMI

(Cryphonectria
parasitica) 		PF00961
(LAGLIDADG_1) 		4 THR A  97
GLN A 100
THR A 104
LYS A 108
 None
 1.15A 6c06C-4yisA:
undetectable		 6c06C-4yisA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yjy CHALCONE SYNTHASE 1

(Oryza sativa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 ILE A 249
THR A 248
THR A 172
ARG A 175
 None
 0.85A 6c06C-4yjyA:
undetectable		 6c06C-4yjyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ysw XANTHINE
DEHYDROGENASE/OXIDAS
E

(Rattus
norvegicus) 		PF00111
(Fer2)
PF00941
(FAD_binding_5)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2)
PF03450
(CO_deh_flav_C) 		4 ILE A 119
THR A 116
THR A  39
GLU A  89
 None
 1.09A 6c06C-4yswA:
undetectable		 6c06C-4yswA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zgv FERREDOXIN RECEPTOR

(Pectobacterium
atrosepticum) 		PF07715
(Plug) 		4 ILE A 678
THR A 630
THR A 633
GLU A 674
 None
 1.15A 6c06C-4zgvA:
undetectable		 6c06C-4zgvA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zoq INTRACELLULAR SERINE
PROTEASE

(Bacillus
licheniformis) 		PF00082
(Peptidase_S8) 		4 ILE I 203
THR I 202
GLU I 139
SER I 391
 None
 1.12A 6c06C-4zoqI:
undetectable		 6c06C-4zoqI:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5amq RNA POLYMERASE L

(California
encephalitis
orthobunyavirus) 		PF04196
(Bunya_RdRp)
PF15518
(L_protein_N) 		4 ILE A 442
THR A 678
THR A 642
SER A 955
 None
None
A  C   4 ( 3.5A)
None
 1.05A 6c06C-5amqA:
undetectable		 6c06C-5amqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5diy HYALURONIDASE

(Thermobaculum
terrenum) 		PF07555
(NAGidase) 		4 ILE A 391
THR A 392
THR A 398
GLU A 410
 None
 0.82A 6c06C-5diyA:
undetectable		 6c06C-5diyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e3t PHOSPHATIDYLINOSITOL
-4-PHOSPHATE
5-KINASE, TYPE I,
ALPHA

(Danio rerio) 		PF01504
(PIP5K) 		4 ILE A 169
ARG A 227
GLU A 145
SER A 141
 ANP  A 501 (-4.5A)
None
None
None
 1.08A 6c06C-5e3tA:
undetectable		 6c06C-5e3tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5erb POLYKETIDE SYNTHASE

(Bacillus
amyloliquefaciens) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		4 ILE A 330
THR A 331
GLU A 339
SER A 338
 None
 0.96A 6c06C-5erbA:
undetectable		 6c06C-5erbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fg0 E3 UBIQUITIN-PROTEIN
LIGASE LISTERIN

(Saccharomyces
cerevisiae) 		no annotation 4 ILE A 106
GLN A 109
GLU A 154
SER A 151
 None
 0.83A 6c06C-5fg0A:
undetectable		 6c06C-5fg0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k4p PROBABLE
PHOSPHATIDYLETHANOLA
MINE TRANSFERASE
MCR-1

(Escherichia
coli) 		PF00884
(Sulfatase) 		4 ILE A 220
THR A 219
THR A 315
ARG A 318
 None
 1.14A 6c06C-5k4pA:
undetectable		 6c06C-5k4pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l5g PLEXIN-A2

(Mus musculus) 		PF01403
(Sema)
PF01437
(PSI)
PF01833
(TIG) 		4 ILE A 860
THR A 861
GLN A 859
SER A 810
 None
 1.07A 6c06C-5l5gA:
undetectable		 6c06C-5l5gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lm7 TRANSCRIPTION
TERMINATION/ANTITERM
INATION PROTEIN NUSA

(Escherichia
coli) 		PF00575
(S1)
PF08529
(NusA_N)
PF13184
(KH_5) 		4 THR A 109
GLN A 108
ARG A 104
GLU A   4
 None
 0.83A 6c06C-5lm7A:
undetectable		 6c06C-5lm7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mxf PHOTORHABDUS
ASYMBIOTICA LECTIN
PHL

(Photorhabdus
asymbiotica) 		PF03984
(DUF346) 		4 ILE A 253
THR A 252
THR A 230
LYS A 277
 None
 1.10A 6c06C-5mxfA:
undetectable		 6c06C-5mxfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o1p ALPHA-AMINOADIPIC
SEMIALDEHYDE
SYNTHASE,
MITOCHONDRIAL

(Homo sapiens) 		PF03435
(Sacchrp_dh_NADP)
PF16653
(Sacchrp_dh_C) 		4 THR A 855
LYS A 912
GLU A 614
SER A 615
 None
 1.12A 6c06C-5o1pA:
undetectable		 6c06C-5o1pA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5opz CHIX

(Serratia
marcescens) 		no annotation 4 ILE A   9
ARG A  35
GLU A  16
SER A  15
 None
 1.00A 6c06C-5opzA:
undetectable		 6c06C-5opzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		4 ILE C1043
THR C1044
THR C1087
ARG C1090
 None
 0.93A 6c06C-5tw1C:
32.9		 6c06C-5tw1C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		4 THR C1044
GLN C1045
THR C1087
ARG C1090
 None
 1.05A 6c06C-5tw1C:
32.9		 6c06C-5tw1C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uc5 CHS2 CHALCONE
SYNTHASE

(Malus domestica) 		no annotation 4 ILE A 246
THR A 245
THR A 169
ARG A 172
 None
 0.85A 6c06C-5uc5A:
undetectable		 6c06C-5uc5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uco 2,4,6-TRIHYDROXYBENZ
OPHENONE SYNTHASE

(Hypericum
androsaemum) 		no annotation 4 ILE A 250
THR A 249
THR A 172
ARG A 175
 None
 0.94A 6c06C-5ucoA:
undetectable		 6c06C-5ucoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uxn PHOSPHO-2-DEHYDRO-3-
DEOXYHEPTONATE
ALDOLASE

(Pseudomonas
aeruginosa) 		no annotation 4 ILE A 356
THR A 355
ARG A 320
SER A 118
 None
None
PEP  A 504 (-3.9A)
PO4  A 502 (-2.4A)
 1.03A 6c06C-5uxnA:
undetectable		 6c06C-5uxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vae ACCESSORY SEC SYSTEM
PROTEIN ASP1

(Streptococcus
gordonii) 		no annotation 4 ILE A 416
GLN A 328
GLU A 333
SER A 332
 None
 1.07A 6c06C-5vaeA:
undetectable		 6c06C-5vaeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vmn BAK PROTEIN

(Singapore
grouper
iridovirus) 		no annotation 4 ILE A  89
THR A  90
GLN A  92
ARG A  95
 None
NO3  A 205 ( 4.9A)
None
None
 1.06A 6c06C-5vmnA:
undetectable		 6c06C-5vmnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5voc ENVELOPE
GLYCOPROTEIN H

(Human
betaherpesvirus
5) 		PF02489
(Herpes_glycop_H)
PF17488
(Herpes_glycoH_C) 		4 ILE A 381
THR A 382
THR A 562
SER A 472
 None
 1.15A 6c06C-5vocA:
2.1		 6c06C-5vocA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9w DNA MISMATCH REPAIR
PROTEIN MUTS

(Neisseria
gonorrhoeae) 		no annotation 4 ILE A 317
GLN A 321
THR A 325
SER A 382
 None
 0.97A 6c06C-5x9wA:
undetectable		 6c06C-5x9wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgu RIBONUCLEASE R

(Escherichia
coli) 		no annotation 4 THR B 364
GLN B 365
THR B 298
GLU B 188
 None
 0.91A 6c06C-5xguB:
2.4		 6c06C-5xguB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnu PUTATIVE INTEGRAL
MEMBRANE PROTEIN

(Escherichia
coli) 		no annotation 4 ILE A 218
THR A 217
THR A 313
ARG A 316
 None
 1.08A 6c06C-5xnuA:
undetectable		 6c06C-5xnuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xw6 P2X PURINOCEPTOR

(Gallus gallus) 		no annotation 4 ILE C 196
GLN C 194
THR C 192
SER C  59
 None
 1.02A 6c06C-5xw6C:
undetectable		 6c06C-5xw6C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfu SPIKE PROTEIN

(Coronavirus
HKU15) 		no annotation 4 ILE A 501
THR A 507
GLU A 485
SER A 287
 None
 0.94A 6c06C-6bfuA:
0.0		 6c06C-6bfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co0 STYRYLPYRONE
SYNTHASE 1

(Piper
methysticum) 		no annotation 4 ILE A 247
THR A 246
THR A 169
ARG A 172
 None
 0.76A 6c06C-6co0A:
undetectable		 6c06C-6co0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b8a PROTEIN
(ASPARTYL-TRNA
SYNTHETASE)

(Thermococcus
kodakarensis) 		PF00152
(tRNA-synt_2)
PF01336
(tRNA_anti-codon) 		3 ARG A 412
LYS A 415
ARG A 130
 ATP  A 500 (-2.5A)
None
None
 1.33A 6c06D-1b8aA:
0.0		 6c06D-1b8aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d8c MALATE SYNTHASE G

(Escherichia
coli) 		PF01274
(Malate_synthase) 		3 ARG A 408
LYS A 404
ARG A  57
 None
 1.29A 6c06D-1d8cA:
0.0		 6c06D-1d8cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fno PEPTIDASE T

(Salmonella
enterica) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 ARG A 292
LYS A 291
ARG A 353
 None
 1.31A 6c06D-1fnoA:
0.0		 6c06D-1fnoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h17 FORMATE
ACETYLTRANSFERASE 1

(Escherichia
coli) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		3 ARG A 681
LYS A 389
ARG A 313
 None
 1.31A 6c06D-1h17A:
1.3		 6c06D-1h17A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hqk 6,7-DIMETHYL-8-RIBIT
YLLUMAZINE SYNTHASE

(Aquifex
aeolicus) 		PF00885
(DMRL_synthase) 		3 ARG A 127
LYS A 135
ARG A  40
 None
 1.25A 6c06D-1hqkA:
0.0		 6c06D-1hqkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ibx DNA FRAGMENTATION
FACTOR 40
CHIMERA OF IGG
BINDING PROTEIN G
AND DNA
FRAGMENTATION FACTOR
45

(Homo sapiens;
Streptococcus
sp.;
Homo sapiens) 		PF02017
(CIDE-N)
PF02017
(CIDE-N) 		3 ARG A  31
LYS A  32
ARG B  43
 None
 1.27A 6c06D-1ibxA:
undetectable		 6c06D-1ibxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmo HEPARIN COFACTOR II

(Homo sapiens) 		PF00079
(Serpin) 		3 ARG A 120
LYS A 123
ARG A 479
 None
 1.34A 6c06D-1jmoA:
0.0		 6c06D-1jmoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lfp HYPOTHETICAL PROTEIN
AQ_1575

(Aquifex
aeolicus) 		PF01709
(Transcrip_reg) 		3 ARG A  21
LYS A  23
ARG A 108
 None
 1.31A 6c06D-1lfpA:
0.0		 6c06D-1lfpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lla HEMOCYANIN (SUBUNIT
TYPE II)

(Limulus
polyphemus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		3 ARG A 586
LYS A 531
ARG A 502
 None
 1.20A 6c06D-1llaA:
0.0		 6c06D-1llaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o4w PIN (PILT
N-TERMINUS) DOMAIN

(Archaeoglobus
fulgidus) 		no annotation 3 ARG A  51
LYS A  50
ARG A  42
 None
 1.15A 6c06D-1o4wA:
0.0		 6c06D-1o4wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1olt OXYGEN-INDEPENDENT
COPROPORPHYRINOGEN
III OXIDASE

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF06969
(HemN_C) 		3 ARG A 371
LYS A 375
ARG A 236
 None
 1.20A 6c06D-1oltA:
undetectable		 6c06D-1oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p7d INTEGRASE

(Escherichia
virus Lambda) 		PF00589
(Phage_integrase)
PF02899
(Phage_int_SAM_1) 		3 ARG A 291
LYS A 294
ARG A 348
 None
 1.22A 6c06D-1p7dA:
undetectable		 6c06D-1p7dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qvr CLPB PROTEIN

(Thermus
thermophilus) 		PF00004
(AAA)
PF02861
(Clp_N)
PF07724
(AAA_2)
PF10431
(ClpB_D2-small) 		3 ARG A 342
LYS A 345
ARG A 518
 None
 1.21A 6c06D-1qvrA:
6.1		 6c06D-1qvrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qxp MU-LIKE CALPAIN

(Bos taurus;
Rattus
norvegicus) 		PF00648
(Peptidase_C2)
PF01067
(Calpain_III)
PF13833
(EF-hand_8) 		3 ARG A 390
LYS A 388
ARG A 630
 None
 1.29A 6c06D-1qxpA:
undetectable		 6c06D-1qxpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tba TRANSCRIPTION
INITIATION FACTOR
IID 230K CHAIN
TRANSCRIPTION
INITIATION FACTOR
TFIID

(Drosophila
melanogaster;
Saccharomyces
cerevisiae) 		PF09247
(TBP-binding)
PF00352
(TBP) 		3 ARG B 107
LYS B 110
ARG A  53
 None
 1.01A 6c06D-1tbaB:
undetectable		 6c06D-1tbaB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u8v GAMMA-AMINOBUTYRATE
METABOLISM
DEHYDRATASE/ISOMERAS
E

(Clostridium
aminobutyricum) 		PF03241
(HpaB)
PF11794
(HpaB_N) 		3 ARG A 238
LYS A 239
ARG A  43
 None
 1.07A 6c06D-1u8vA:
3.4		 6c06D-1u8vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yt8 THIOSULFATE
SULFURTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00581
(Rhodanese) 		3 ARG A 407
LYS A 406
ARG A 492
 None
 1.13A 6c06D-1yt8A:
undetectable		 6c06D-1yt8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ab5 MRNA MATURASE

(Saccharomyces
cerevisiae) 		PF00961
(LAGLIDADG_1) 		3 ARG A 298
LYS A 490
ARG A 502
 SO4  A 603 (-3.8A)
None
None
 1.12A 6c06D-2ab5A:
undetectable		 6c06D-2ab5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bas YKUI PROTEIN

(Bacillus
subtilis) 		PF00563
(EAL)
PF10388
(YkuI_C) 		3 ARG A 361
LYS A 362
ARG A 278
 None
 1.24A 6c06D-2basA:
undetectable		 6c06D-2basA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cul GLUCOSE-INHIBITED
DIVISION PROTEIN
A-RELATED PROTEIN,
PROBABLE
OXIDOREDUCTASE

(Thermus
thermophilus) 		PF01134
(GIDA) 		3 ARG A 197
LYS A 196
ARG A 222
 None
 1.35A 6c06D-2culA:
undetectable		 6c06D-2culA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dht 409AA LONG
HYPOTHETICAL
NADP-DEPENDENT
ISOCITRATE
DEHYDROGENASE

(Sulfurisphaera
tokodaii) 		PF00180
(Iso_dh) 		3 ARG A  79
LYS A 109
ARG A 149
 None
 1.15A 6c06D-2dhtA:
undetectable		 6c06D-2dhtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fcc ENDONUCLEASE V

(Escherichia
virus T4) 		PF03013
(Pyr_excise) 		3 ARG A 125
LYS A 121
ARG A  70
 None
SO4  A 502 (-3.0A)
GOL  A 602 (-3.9A)
 0.93A 6c06D-2fccA:
undetectable		 6c06D-2fccA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ftp HYDROXYMETHYLGLUTARY
L-COA LYASE

(Pseudomonas
aeruginosa) 		PF00682
(HMGL-like) 		3 ARG A 291
LYS A 294
ARG A 279
 None
 1.19A 6c06D-2ftpA:
undetectable		 6c06D-2ftpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i1j MOESIN

(Spodoptera
frugiperda) 		PF00373
(FERM_M)
PF00769
(ERM)
PF09379
(FERM_N)
PF09380
(FERM_C) 		3 ARG A  40
LYS A  35
ARG A 353
 None
 0.75A 6c06D-2i1jA:
undetectable		 6c06D-2i1jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i1j MOESIN

(Spodoptera
frugiperda) 		PF00373
(FERM_M)
PF00769
(ERM)
PF09379
(FERM_N)
PF09380
(FERM_C) 		3 ARG A 506
LYS A 553
ARG A 156
 None
 1.37A 6c06D-2i1jA:
undetectable		 6c06D-2i1jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2id5 LEUCINE RICH REPEAT
NEURONAL 6A

(Homo sapiens) 		PF07679
(I-set)
PF13306
(LRR_5)
PF13855
(LRR_8) 		3 ARG A 201
LYS A 203
ARG A 245
 None
NAG  A 488 (-3.9A)
None
 1.32A 6c06D-2id5A:
undetectable		 6c06D-2id5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2l7b APOLIPOPROTEIN E

(Homo sapiens) 		PF01442
(Apolipoprotein) 		3 ARG A 142
LYS A 146
ARG A 274
 None
 1.06A 6c06D-2l7bA:
1.9		 6c06D-2l7bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p1n TRANSPORT INHIBITOR
RESPONSE 1 PROTEIN

(Arabidopsis
thaliana) 		PF12937
(F-box-like) 		3 ARG B  46
LYS B  47
ARG B 164
 None
 1.12A 6c06D-2p1nB:
undetectable		 6c06D-2p1nB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q1f CHONDROITINASE

(Bacteroides
thetaiotaomicron) 		PF02278
(Lyase_8)
PF09092
(Lyase_N)
PF09093
(Lyase_catalyt) 		3 ARG A 489
LYS A 492
ARG A 582
 None
 1.34A 6c06D-2q1fA:
undetectable		 6c06D-2q1fA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q4a CLAVAMINATE
SYNTHASE-LIKE
PROTEIN AT3G21360

(Arabidopsis
thaliana) 		PF02668
(TauD) 		3 ARG A 316
LYS A 116
ARG A 179
 None
 1.05A 6c06D-2q4aA:
undetectable		 6c06D-2q4aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vq8 RNASE ZF-1A

(Danio rerio) 		PF00074
(RnaseA) 		3 ARG A  58
LYS A  57
ARG A  25
 None
 1.27A 6c06D-2vq8A:
undetectable		 6c06D-2vq8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3agb RED CHLOROPHYLL
CATABOLITE
REDUCTASE,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF06405
(RCC_reductase) 		3 ARG A  91
LYS A  51
ARG A  62
 None
 1.13A 6c06D-3agbA:
undetectable		 6c06D-3agbA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bln ACETYLTRANSFERASE
GNAT FAMILY

(Bacillus cereus) 		PF00583
(Acetyltransf_1) 		3 ARG A  77
LYS A  75
ARG A  28
 None
 0.97A 6c06D-3blnA:
undetectable		 6c06D-3blnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eab SPASTIN
CHMP1B

(Homo sapiens;
Homo sapiens) 		no annotation
no annotation 		3 ARG A 176
LYS A 180
ARG G 196
 None
 1.32A 6c06D-3eabA:
3.0		 6c06D-3eabA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3emk GLUCOSE/RIBITOL
DEHYDROGENASE

(Brucella
melitensis) 		PF13561
(adh_short_C2) 		3 ARG A  64
LYS A  68
ARG A 129
 None
 1.05A 6c06D-3emkA:
undetectable		 6c06D-3emkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fwx PEPTIDE DEFORMYLASE

(Vibrio cholerae) 		PF01327
(Pep_deformylase) 		3 ARG A 154
LYS A 151
ARG A 103
 None
 1.19A 6c06D-3fwxA:
undetectable		 6c06D-3fwxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j1c CHAPERONIN ALPHA
SUBUNIT

(Acidianus
tengchongensis) 		PF00118
(Cpn60_TCP1) 		3 ARG A  20
LYS A  24
ARG A  38
 None
 1.09A 6c06D-3j1cA:
undetectable		 6c06D-3j1cA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j3i CAPSID PROTEIN

(Penicillium
chrysogenum
virus) 		no annotation 3 ARG A 969
LYS A 971
ARG A 738
 None
 1.35A 6c06D-3j3iA:
undetectable		 6c06D-3j3iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR SPP42
PRE-MRNA-PROCESSING
PROTEIN 45
PRE-MRNA-SPLICING
FACTOR CWF15

(Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe;
Schizosaccharomyces
pombe) 		PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV)
PF02731
(SKIP_SNW)
PF01423
(LSM) 		3 ARG A 673
LYS h  24
ARG M 218
 G  C  39 ( 3.8A)
None
None
 1.37A 6c06D-3jb9A:
undetectable		 6c06D-3jb9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kfl METHIONYL-TRNA
SYNTHETASE

(Leishmania
major) 		PF09334
(tRNA-synt_1g) 		3 ARG A 300
LYS A 285
ARG A 243
 EDO  A 817 ( 4.0A)
EDO  A 817 (-4.1A)
EDO  A 813 (-4.0A)
 1.35A 6c06D-3kflA:
2.1		 6c06D-3kflA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kuf FRAGILE X MENTAL
RETARDATION
SYNDROME-RELATED
PROTEIN 1

(Homo sapiens) 		PF05641
(Agenet) 		3 ARG A  84
LYS A  82
ARG A  47
 None
GOL  A 134 (-3.0A)
None
 1.35A 6c06D-3kufA:
undetectable		 6c06D-3kufA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ldg PUTATIVE
UNCHARACTERIZED
PROTEIN SMU.472

(Streptococcus
mutans) 		PF01170
(UPF0020)
PF02926
(THUMP) 		3 ARG A 154
LYS A  60
ARG A 167
 None
 1.23A 6c06D-3ldgA:
undetectable		 6c06D-3ldgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3luy PROBABLE CHORISMATE
MUTASE

(Bifidobacterium
adolescentis) 		PF00800
(PDT) 		3 ARG A 244
LYS A 242
ARG A 185
 None
 1.04A 6c06D-3luyA:
undetectable		 6c06D-3luyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mbf FRUCTOSE-BISPHOSPHAT
E ALDOLASE

(Encephalitozoon
cuniculi) 		PF00274
(Glycolytic) 		3 ARG A  36
LYS A  32
ARG A 125
 None
 1.19A 6c06D-3mbfA:
0.0		 6c06D-3mbfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o07 PYRIDOXINE
BIOSYNTHESIS PROTEIN
SNZ1

(Saccharomyces
cerevisiae) 		PF01680
(SOR_SNZ) 		3 ARG A 165
LYS A 161
ARG A  52
 None
 1.27A 6c06D-3o07A:
undetectable		 6c06D-3o07A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q0g ENOYL-COA HYDRATASE
ECHA8

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		3 ARG A 205
LYS A 208
ARG A 178
 None
 1.20A 6c06D-3q0gA:
3.8		 6c06D-3q0gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sbx PUTATIVE
UNCHARACTERIZED
PROTEIN

(Mycobacterium
marinum) 		PF03641
(Lysine_decarbox) 		3 ARG A  98
LYS A  99
ARG A 170
 AMP  A 188 (-3.1A)
AMP  A 188 (-2.6A)
None
 1.21A 6c06D-3sbxA:
undetectable		 6c06D-3sbxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxf CALMODULIN-DOMAIN
PROTEIN KINASE 1

(Toxoplasma
gondii) 		PF00069
(Pkinase)
PF13499
(EF-hand_7) 		3 ARG A 145
LYS A 144
ARG A 445
 None
 1.29A 6c06D-3sxfA:
undetectable		 6c06D-3sxfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ti8 NEURAMINIDASE

(Influenza A
virus) 		PF00064
(Neur) 		3 ARG A 434
LYS A 430
ARG A 152
 None
None
LNV  A 901 (-4.0A)
 1.15A 6c06D-3ti8A:
undetectable		 6c06D-3ti8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vib MTRR

(Neisseria
gonorrhoeae) 		PF00440
(TetR_N)
PF08361
(TetR_C_2) 		3 ARG A 137
LYS A 167
ARG A  98
 None
PO4  A 211 ( 2.6A)
None
 1.27A 6c06D-3vibA:
3.5		 6c06D-3vibA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wdj TYPE I PULLULANASE

(Anoxybacillus
sp. LM18-11) 		PF00128
(Alpha-amylase)
PF02922
(CBM_48) 		3 ARG A 241
LYS A 243
ARG A 574
 None
 1.17A 6c06D-3wdjA:
undetectable		 6c06D-3wdjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zn8 SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN

(Sulfolobus
solfataricus) 		PF02978
(SRP_SPB) 		3 ARG M 426
LYS M 429
ARG M 330
 None
 1.23A 6c06D-3zn8M:
undetectable		 6c06D-3zn8M:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ags THIOL-DEPENDENT
REDUCTASE 1

(Leishmania
infantum) 		PF13417
(GST_N_3)
PF16865
(GST_C_5) 		3 ARG A   4
LYS A   4
ARG A  25
 None
 1.12A 6c06D-4agsA:
undetectable		 6c06D-4agsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bpc RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE S

(Homo sapiens) 		PF00102
(Y_phosphatase) 		3 ARG A1787
LYS A1789
ARG A1919
 None
 0.85A 6c06D-4bpcA:
undetectable		 6c06D-4bpcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cem REGULATOR OF
NONSENSE TRANSCRIPTS
2

(Homo sapiens) 		PF02854
(MIF4G) 		3 ARG A 325
LYS A 328
ARG A 141
 None
 1.30A 6c06D-4cemA:
3.0		 6c06D-4cemA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d86 POLY [ADP-RIBOSE]
POLYMERASE 14

(Homo sapiens) 		PF01661
(Macro) 		3 ARG A1113
LYS A1154
ARG A 898
 None
 1.14A 6c06D-4d86A:
undetectable		 6c06D-4d86A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dvg RHO-LIKE SMALL
GTPASE
DIAPHANOUS PROTEIN

(Entamoeba
histolytica;
Entamoeba
histolytica) 		PF00071
(Ras)
PF06367
(Drf_FH3)
PF06371
(Drf_GBD) 		3 ARG B 197
LYS B 198
ARG A  83
 None
 1.02A 6c06D-4dvgB:
0.7		 6c06D-4dvgB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e2i LARGE T ANTIGEN

(Macaca mulatta
polyomavirus 1) 		PF06431
(Polyoma_lg_T_C) 		3 ARG A 548
LYS A 550
ARG A 559
 None
 1.36A 6c06D-4e2iA:
undetectable		 6c06D-4e2iA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exp MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR

(Mus musculus) 		PF00047
(ig) 		3 ARG X 261
LYS X 259
ARG X 197
 None
 1.21A 6c06D-4expX:
undetectable		 6c06D-4expX:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gni PUTATIVE HEAT SHOCK
PROTEIN

(Chaetomium
thermophilum) 		PF00012
(HSP70) 		3 ARG A 268
LYS A 247
ARG A 329
 None
 1.33A 6c06D-4gniA:
undetectable		 6c06D-4gniA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h10 ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR-LIKE
PROTEIN 1
CIRCADIAN LOCOMOTER
OUTPUT CYCLES
PROTEIN KAPUT

(Homo sapiens;
Homo sapiens) 		PF00010
(HLH)
PF00010
(HLH) 		3 ARG A  83
LYS A  87
ARG B  82
 None
 1.28A 6c06D-4h10A:
undetectable		 6c06D-4h10A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3j HEPATOCYTE GROWTH
FACTOR
HEPATOCYTE GROWTH
FACTOR BETA CHAIN

(Homo sapiens;
Homo sapiens) 		PF00089
(Trypsin)
PF01403
(Sema)
PF01437
(PSI) 		3 ARG A 630
LYS A 495
ARG B 143
 None
 1.33A 6c06D-4k3jA:
undetectable		 6c06D-4k3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5y CORTICOTROPIN-RELEAS
ING FACTOR RECEPTOR
1, T4-LYSOZYME
CHIMERIC CONSTRUCT

(Homo sapiens;
Escherichia
virus T4) 		PF00002
(7tm_2)
PF00959
(Phage_lysozyme) 		3 ARG A1008
LYS A1060
ARG A 292
 None
 0.90A 6c06D-4k5yA:
2.1		 6c06D-4k5yA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kw3 NS1

(Human bocavirus) 		no annotation 3 ARG A 148
LYS A  80
ARG A 257
 None
 1.33A 6c06D-4kw3A:
undetectable		 6c06D-4kw3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4me4 METAL DEPENDENT
PHOSPHOHYDROLASE

(Persephonella
marina) 		PF01590
(GAF)
PF01966
(HD) 		3 ARG A  93
LYS A  70
ARG A 101
 None
 1.30A 6c06D-4me4A:
undetectable		 6c06D-4me4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n4r LPS-ASSEMBLY
LIPOPROTEIN LPTE

(Salmonella
enterica) 		PF04390
(LptE) 		3 ARG B 124
LYS B 150
ARG B  24
 None
 1.27A 6c06D-4n4rB:
undetectable		 6c06D-4n4rB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nkr MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN
B

(Bacillus
subtilis) 		PF03205
(MobB) 		3 ARG A  64
LYS A  63
ARG A  87
 None
 1.10A 6c06D-4nkrA:
undetectable		 6c06D-4nkrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oxi ENTEROBACTIN
SYNTHETASE COMPONENT
F-RELATED PROTEIN

(Vibrio cholerae) 		PF00501
(AMP-binding) 		3 ARG A 446
LYS A 452
ARG A 110
 GAP  A 601 (-4.3A)
GAP  A 601 (-2.8A)
None
 1.07A 6c06D-4oxiA:
undetectable		 6c06D-4oxiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A

(Vibrio cholerae) 		PF05896
(NQRA)
PF11973
(NQRA_SLBB) 		3 ARG A 115
LYS A 119
ARG A 318
 None
 1.06A 6c06D-4p6vA:
undetectable		 6c06D-4p6vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pzk TRNA
(CYTIDINE(34)-2'-O)-
METHYLTRANSFERASE

(Bacillus
anthracis) 		PF00588
(SpoU_methylase) 		3 ARG A  47
LYS A  43
ARG A  34
 None
 1.36A 6c06D-4pzkA:
undetectable		 6c06D-4pzkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qn0 ENDONUCLEASE G,
MITOCHONDRIAL

(Caenorhabditis
elegans) 		PF01223
(Endonuclease_NS) 		3 ARG A 193
LYS A 196
ARG A  65
 None
 0.88A 6c06D-4qn0A:
undetectable		 6c06D-4qn0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvw ZNUD

(Neisseria
meningitidis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		3 ARG A 486
LYS A  82
ARG A 232
 None
 1.00A 6c06D-4rvwA:
undetectable		 6c06D-4rvwA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u9o NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT A

(Vibrio cholerae) 		PF05896
(NQRA)
PF11973
(NQRA_SLBB) 		3 ARG A 115
LYS A 119
ARG A 318
 None
 1.07A 6c06D-4u9oA:
undetectable		 6c06D-4u9oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uv6 APICAL MEROZOITE
ANTIGEN 1

(Plasmodium
knowlesi) 		PF02430
(AMA-1) 		3 ARG A 180
LYS A 237
ARG A  66
 None
 1.33A 6c06D-4uv6A:
undetectable		 6c06D-4uv6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ymk ACYL-COA DESATURASE
1

(Mus musculus) 		PF00487
(FA_desaturase) 		3 ARG A 154
LYS A 158
ARG A 346
 None
 1.24A 6c06D-4ymkA:
undetectable		 6c06D-4ymkA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5anb ELONGATION FACTOR TU
GTP-BINDING
DOMAIN-CONTAINING
PROTEIN 1

(Homo sapiens) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF14492
(EFG_II) 		3 ARG K 250
LYS K 260
ARG K 192
 None
 1.08A 6c06D-5anbK:
undetectable		 6c06D-5anbK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cr4 SLEEPING BEAUTY
TRANSPOSASE, SB100X

(synthetic
construct) 		PF01498
(HTH_Tnp_Tc3_2)
PF13358
(DDE_3) 		3 ARG A 180
LYS A 176
ARG A 216
 None
GOL  A 314 ( 4.3A)
None
 1.35A 6c06D-5cr4A:
undetectable		 6c06D-5cr4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5d79 BERBERINE BRIDGE
ENZYME-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		3 ARG A 143
LYS A 245
ARG A 420
 None
 1.37A 6c06D-5d79A:
undetectable		 6c06D-5d79A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dot CARBAMOYL-PHOSPHATE
SYNTHASE [AMMONIA],
MITOCHONDRIAL

(Homo sapiens) 		PF00117
(GATase)
PF00988
(CPSase_sm_chain)
PF02142
(MGS)
PF02786
(CPSase_L_D2)
PF02787
(CPSase_L_D3) 		3 ARG A1129
LYS A1139
ARG A1453
 None
 0.99A 6c06D-5dotA:
undetectable		 6c06D-5dotA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f4b NAD(P)H
DEHYDROGENASE
(QUINONE)

(Brucella
abortus) 		PF03358
(FMN_red) 		3 ARG A 173
LYS A 173
ARG A 184
 None
 0.97A 6c06D-5f4bA:
undetectable		 6c06D-5f4bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw7 GLUCOSIDASE YGJK

(Escherichia
coli) 		PF01204
(Trehalase) 		3 ARG A 281
LYS A 285
ARG A 295
 None
 1.23A 6c06D-5gw7A:
2.4		 6c06D-5gw7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5huc 3-DEOXY-D-ARABINO-HE
PTULOSONATE
7-PHOSPHATE (DAHP)
SYNTHASE

(Corynebacterium
glutamicum) 		PF01474
(DAHP_synth_2) 		3 ARG A 145
LYS A 143
ARG A 181
 None
PEP  A 502 ( 3.8A)
MPD  A 504 ( 4.9A)
 1.24A 6c06D-5hucA:
undetectable		 6c06D-5hucA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ii0 CALCITONIN RECEPTOR

(Homo sapiens) 		PF02793
(HRM) 		3 ARG A  58
LYS A  54
ARG A  45
 None
 1.36A 6c06D-5ii0A:
undetectable		 6c06D-5ii0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kdx METALLOPEPTIDASE

(Pseudomonas
aeruginosa) 		PF13402
(Peptidase_M60) 		3 ARG A 468
LYS A 542
ARG A 582
 None
 1.29A 6c06D-5kdxA:
0.7		 6c06D-5kdxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lj3 PRE-MRNA-SPLICING
FACTOR BUD31

(Saccharomyces
cerevisiae) 		PF01125
(G10) 		3 ARG L   7
LYS L   5
ARG L  31
 None
 1.33A 6c06D-5lj3L:
undetectable		 6c06D-5lj3L:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mtj TYROSINE-PROTEIN
KINASE YES

(Mus musculus) 		PF00017
(SH2) 		3 ARG A 186
LYS A 184
ARG A 176
 None
SO4  A 301 (-3.9A)
None
 1.10A 6c06D-5mtjA:
undetectable		 6c06D-5mtjA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 3 ARG B 481
LYS B 106
ARG B 835
 None
 1.36A 6c06D-5nd1B:
undetectable		 6c06D-5nd1B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o7b PUTATIVE LOW
MOLECULAR WEIGHT
PROTEIN-TYROSINE-PHO
SPHATASE SLR0328

(Synechocystis
sp. PCC 6803) 		no annotation 3 ARG A  70
LYS A  68
ARG A  53
 None
 1.05A 6c06D-5o7bA:
undetectable		 6c06D-5o7bA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ovu BETA-PROTEOBACTERIA
PROTEASOME HOMOLOGUE

(Cupriavidus
metallidurans) 		no annotation 3 ARG A  29
LYS A  32
ARG A 163
 None
 1.33A 6c06D-5ovuA:
undetectable		 6c06D-5ovuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t1a CHIMERA PROTEIN OF
CC CHEMOKINE
RECEPTOR TYPE 2
ISOFORM B AND
T4-LYSOZYME,LYSOZYME

(Homo sapiens;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00959
(Phage_lysozyme) 		3 ARG A 232
LYS A 239
ARG A 313
 OLC  A1207 (-3.5A)
OLC  A1207 (-3.7A)
None
 1.31A 6c06D-5t1aA:
1.9		 6c06D-5t1aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tbf TRANSLATION
ELONGATION FACTOR

(Vibrio cholerae) 		PF11826
(DUF3346) 		3 ARG A 407
LYS A 404
ARG A 390
 None
 1.14A 6c06D-5tbfA:
undetectable		 6c06D-5tbfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w40 POPP2 PROTEIN

(Ralstonia
solanacearum) 		PF03421
(Acetyltransf_14) 		3 ARG A 322
LYS A 322
ARG A 416
 SCY  A 321 ( 4.0A)
SCY  A 321 ( 3.0A)
IHP  A 501 (-3.5A)
 1.30A 6c06D-5w40A:
undetectable		 6c06D-5w40A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w8x LIPID-A-DISACCHARIDE
SYNTHASE

(Escherichia
coli) 		no annotation 3 ARG A  27
LYS A  30
ARG A   5
 None
 1.15A 6c06D-5w8xA:
undetectable		 6c06D-5w8xA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xyi 40S RIBOSOMAL
PROTEIN S4
RIBOSOMAL PROTEIN
S24E, PUTATIVE

(Trichomonas
vaginalis;
Trichomonas
vaginalis) 		PF00900
(Ribosomal_S4e)
PF01479
(S4)
PF08071
(RS4NT)
PF16121
(40S_S4_C)
PF01282
(Ribosomal_S24e) 		3 ARG E  51
LYS E  53
ARG Y  89
 None
 1.25A 6c06D-5xyiE:
undetectable		 6c06D-5xyiE:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y58 ATP-DEPENDENT DNA
HELICASE II SUBUNIT
2

(Saccharomyces
cerevisiae) 		no annotation 3 ARG B  41
LYS B  36
ARG B  86
 U  X 290 ( 4.6A)
None
None
 1.17A 6c06D-5y58B:
undetectable		 6c06D-5y58B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y6q ALDEHYDE OXIDASE
MEDIUM SUBUNIT
ALDEHYDE OXIDASE
LARGE SUBUNIT

(Methylobacillus
sp. KY4400;
Methylobacillus
sp. KY4400) 		no annotation
no annotation 		3 ARG C 656
LYS C 655
ARG B 321
 None
 1.19A 6c06D-5y6qC:
undetectable		 6c06D-5y6qC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zmy -

(-) 		no annotation 3 ARG A 173
LYS A 178
ARG A  31
 None
None
TAR  A 401 (-3.2A)
 1.25A 6c06D-5zmyA:
undetectable		 6c06D-5zmyA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zq4 SIDE

(Legionella
pneumophila) 		no annotation 3 ARG B 351
LYS B 377
ARG B 310
 None
 1.12A 6c06D-5zq4B:
undetectable		 6c06D-5zq4B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aon DIHYDROLIPOYL
DEHYDROGENASE

(Bordetella
pertussis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		3 ARG A 449
LYS A 462
ARG A 397
 None
 1.18A 6c06D-6aonA:
undetectable		 6c06D-6aonA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY
CRISPR-ASSOCIATED
PROTEIN, CAS5E
FAMILY

(Thermobifida
fusca;
Thermobifida
fusca) 		no annotation
no annotation 		3 ARG A 472
LYS A 476
ARG M 171
 None
 1.02A 6c06D-6c66A:
2.3		 6c06D-6c66A:
undetectable