SIMILAR PATTERNS OF AMINO ACIDS FOR 6BZO_C_FI8C1201_2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h17 FORMATE
ACETYLTRANSFERASE 1

(Escherichia
coli) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 LEU A 343
ASP A 344
GLN A  30
VAL A 420
 None
 1.21A 6bzoF-1h17A:
0.0		 6bzoF-1h17A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kpi CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE 2

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		4 LEU A  35
ASP A  36
GLN A  57
VAL A  17
 None
 1.23A 6bzoF-1kpiA:
0.0		 6bzoF-1kpiA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1krh BENZOATE
1,2-DIOXYGENASE
REDUCTASE

(Acinetobacter
sp.) 		PF00111
(Fer2)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 LEU A 259
ASP A 260
GLN A 263
VAL A 313
 None
 1.31A 6bzoF-1krhA:
undetectable		 6bzoF-1krhA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9n MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN
B

(Escherichia
coli) 		PF03205
(MobB) 		4 LEU A  85
ASP A  84
GLN A  86
VAL A 136
 None
 1.48A 6bzoF-1p9nA:
undetectable		 6bzoF-1p9nA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjm LACTOFERRIN

(Equus caballus) 		PF00405
(Transferrin) 		4 LEU A 318
ASP A 315
GLN A 313
VAL A 410
 None
 1.23A 6bzoF-1qjmA:
0.0		 6bzoF-1qjmA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w18 LEVANSUCRASE

(Gluconacetobacter
diazotrophicus) 		PF02435
(Glyco_hydro_68) 		4 LEU A 462
ASP A 461
GLN A 476
VAL A 359
 None
 1.49A 6bzoF-1w18A:
undetectable		 6bzoF-1w18A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 LEU A 351
ASP A 219
GLN A 193
VAL A 315
 None
 1.48A 6bzoF-1wl4A:
0.0		 6bzoF-1wl4A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytu HYPOTHETICAL PROTEIN
AF1318

(Archaeoglobus
fulgidus) 		PF02171
(Piwi) 		4 LEU A 157
ASP A 154
GLN A  67
VAL A 100
 None
 1.40A 6bzoF-1ytuA:
0.0		 6bzoF-1ytuA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaz THYMIDYLATE SYNTHASE

(Cryptococcus
neoformans) 		PF00303
(Thymidylat_synt) 		4 LEU A 153
ASP A 151
GLN A 154
VAL A 301
 None
 1.42A 6bzoF-2aazA:
undetectable		 6bzoF-2aazA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h84 STEELY1

(Dictyostelium
discoideum) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 LEU A3030
ASP A2971
GLN A2972
VAL A2896
 P6G  A1000 ( 4.4A)
P6G  A1000 (-3.3A)
None
None
 1.43A 6bzoF-2h84A:
undetectable		 6bzoF-2h84A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hhz PYRIDOXAMINE
5'-PHOSPHATE
OXIDASE-RELATED

(Streptococcus
suis) 		PF01243
(Putative_PNPOx) 		4 LEU A  21
ASP A  22
GLN A  55
VAL A  76
 None
None
PO4  A 150 ( 4.4A)
None
 1.44A 6bzoF-2hhzA:
undetectable		 6bzoF-2hhzA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixo SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 1

(Saccharomyces
cerevisiae) 		PF03095
(PTPA) 		4 LEU A 105
ASP A 106
GLN A 129
VAL A 211
 None
 1.20A 6bzoF-2ixoA:
undetectable		 6bzoF-2ixoA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 273
ASP A 279
GLN A 126
VAL A  72
 None
 1.34A 6bzoF-2jamA:
undetectable		 6bzoF-2jamA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE

(Nostoc
punctiforme) 		PF00221
(Lyase_aromatic) 		4 LEU A 242
ASP A 238
GLN A 473
VAL A 487
 None
 1.49A 6bzoF-2nyfA:
1.2		 6bzoF-2nyfA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obe HEXON

(Human
mastadenovirus
E) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		4 LEU A 688
ASP A 689
GLN A 352
VAL A  81
 None
 1.39A 6bzoF-2obeA:
undetectable		 6bzoF-2obeA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsj SULFITE REDUCTASE
ALPHA SUBUNIT

(Desulfomicrobium
norvegicum) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 LEU A   9
ASP A  10
GLN A  13
VAL A 140
 None
 1.47A 6bzoF-2xsjA:
undetectable		 6bzoF-2xsjA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yoc PULLULANASE

(Klebsiella
oxytoca) 		PF02922
(CBM_48)
PF03714
(PUD)
PF11852
(DUF3372) 		4 LEU A 245
ASP A 242
GLN A 246
VAL A 626
 None
SO4  A2078 (-4.4A)
SO4  A2078 (-3.5A)
None
 1.32A 6bzoF-2yocA:
undetectable		 6bzoF-2yocA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bhw UNCHARACTERIZED
PROTEIN

(Magnetospirillum
magneticum) 		PF08849
(DUF1819) 		4 LEU A 170
ASP A 117
GLN A 110
VAL A  88
 None
 1.45A 6bzoF-3bhwA:
undetectable		 6bzoF-3bhwA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cj1 ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE 2

(Rattus
norvegicus) 		PF01150
(GDA1_CD39) 		4 LEU A 202
ASP A 201
GLN A 208
VAL A 279
 None
 1.43A 6bzoF-3cj1A:
undetectable		 6bzoF-3cj1A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g64 PUTATIVE ENOYL-COA
HYDRATASE

(Streptomyces
coelicolor) 		PF00378
(ECH_1) 		4 LEU A 228
ASP A 244
GLN A 248
VAL A  60
 None
 1.41A 6bzoF-3g64A:
undetectable		 6bzoF-3g64A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmu AMINOTRANSFERASE,
CLASS III

(Ruegeria
pomeroyi) 		PF00202
(Aminotran_3) 		4 LEU A 447
ASP A 448
GLN A 451
VAL A 238
 None
 1.15A 6bzoF-3hmuA:
undetectable		 6bzoF-3hmuA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxl UNCHARACTERIZED
PROTEIN DSY3957

(Desulfitobacterium
hafniense) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N)
PF17482
(Phage_sheath_1C) 		4 LEU A  72
ASP A  69
GLN A  71
VAL A 234
 None
 1.40A 6bzoF-3hxlA:
undetectable		 6bzoF-3hxlA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3v PROBABLE SECRETED
SOLUTE-BINDING
LIPOPROTEIN

(Streptomyces
coelicolor) 		PF01547
(SBP_bac_1) 		4 LEU A  83
ASP A  82
GLN A  85
VAL A 148
 None
 1.33A 6bzoF-3i3vA:
undetectable		 6bzoF-3i3vA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lqz HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DP ALPHA 1
CHAIN

(Homo sapiens) 		PF00993
(MHC_II_alpha)
PF07654
(C1-set) 		4 LEU A 170
ASP A 171
GLN A 172
VAL A 132
 None
 1.44A 6bzoF-3lqzA:
undetectable		 6bzoF-3lqzA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6r PROPIONYL-COA
CARBOXYLASE, ALPHA
SUBUNIT
PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT

(Ruegeria
pomeroyi;
Roseobacter
denitrificans) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF01039
(Carboxyl_trans) 		4 LEU B 362
ASP B 367
GLN B 403
VAL A 723
 None
 1.03A 6bzoF-3n6rB:
undetectable		 6bzoF-3n6rB:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgi DNA LIGASE

(Mycobacterium
tuberculosis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB) 		4 LEU A 119
ASP A 302
GLN A 307
VAL A 185
 None
 1.34A 6bzoF-3sgiA:
2.3		 6bzoF-3sgiA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		4 LEU A 793
ASP A 813
GLN A 811
VAL A 742
 None
 1.38A 6bzoF-3syjA:
undetectable		 6bzoF-3syjA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5w COMPLEMENT C5

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2) 		4 LEU A 379
ASP A 377
GLN A 381
VAL A 612
 None
 1.49A 6bzoF-4a5wA:
3.1		 6bzoF-4a5wA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aod ACETYLCHOLINE-BINDIN
G PROTEIN TYPE 1

(Biomphalaria
glabrata) 		PF02931
(Neur_chan_LBD) 		4 LEU A  37
ASP A 165
GLN A  38
VAL A  45
 None
 1.34A 6bzoF-4aodA:
undetectable		 6bzoF-4aodA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dj2 PERIOD CIRCADIAN
PROTEIN HOMOLOG 1

(Mus musculus) 		PF08447
(PAS_3) 		4 LEU A 384
ASP A 387
GLN A 261
VAL A 240
 None
 1.31A 6bzoF-4dj2A:
undetectable		 6bzoF-4dj2A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwq TRNA-SPLICING LIGASE
RTCB

(Pyrococcus
horikoshii) 		PF01139
(RtcB) 		4 LEU A 268
ASP A 265
GLN A  46
VAL A 334
 None
 1.36A 6bzoF-4dwqA:
0.8		 6bzoF-4dwqA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e9k HYPOTHETICAL PROTEIN

(Bacteroides
ovatus) 		PF14717
(DUF4465) 		4 LEU A 215
ASP A 216
GLN A 217
VAL A 157
 None
 1.49A 6bzoF-4e9kA:
undetectable		 6bzoF-4e9kA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g56 HSL7 PROTEIN

(Xenopus laevis) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		4 LEU A 129
ASP A  88
GLN A 123
VAL A  15
 None
 1.44A 6bzoF-4g56A:
undetectable		 6bzoF-4g56A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)

(Geobacillus
kaustophilus) 		PF00854
(PTR2) 		4 LEU A 326
ASP A 327
GLN A 325
VAL A 410
 None
 1.50A 6bzoF-4ikvA:
2.4		 6bzoF-4ikvA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q73 PROLINE
DEHYDROGENASE

(Bradyrhizobium
diazoefficiens) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		4 LEU A 264
ASP A 263
GLN A 260
VAL A 168
 None
 1.37A 6bzoF-4q73A:
3.0		 6bzoF-4q73A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnm IMPORTIN SUBUNIT
ALPHA

(Arabidopsis
thaliana) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3) 		4 LEU A 326
ASP A 327
GLN A 329
VAL A 378
 None
 1.30A 6bzoF-4tnmA:
2.5		 6bzoF-4tnmA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u10 POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE

(Aggregatibacter
actinomycetemcomitans) 		PF01522
(Polysacc_deac_1) 		4 LEU A 128
ASP A 129
GLN A 222
VAL A  94
 None
 1.45A 6bzoF-4u10A:
undetectable		 6bzoF-4u10A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u33 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF11896
(DUF3416) 		4 LEU A 396
ASP A 392
GLN A 361
VAL A 317
 None
 1.14A 6bzoF-4u33A:
undetectable		 6bzoF-4u33A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uaq PROTEIN TRANSLOCASE
SUBUNIT SECA 2

(Mycobacterium
tuberculosis) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 LEU A 594
ASP A 595
GLN A 598
VAL A 432
 None
 1.27A 6bzoF-4uaqA:
undetectable		 6bzoF-4uaqA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uop LIPOTEICHOIC ACID
PRIMASE

(Listeria
monocytogenes) 		PF00884
(Sulfatase) 		4 LEU A 257
ASP A 258
GLN A 261
VAL A 274
 None
 0.95A 6bzoF-4uopA:
undetectable		 6bzoF-4uopA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y21 PROTEIN UNC-13
HOMOLOG A

(Rattus
norvegicus) 		PF06292
(DUF1041)
PF10540
(Membr_traf_MHD) 		4 LEU A 429
ASP A 426
GLN A 430
VAL A 455
 None
 1.36A 6bzoF-4y21A:
3.2		 6bzoF-4y21A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yke MRE11

(Chaetomium
thermophilum) 		PF00149
(Metallophos)
PF04152
(Mre11_DNA_bind) 		4 LEU A 137
ASP A 138
GLN A 141
VAL A 237
 None
 0.87A 6bzoF-4ykeA:
undetectable		 6bzoF-4ykeA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxc FLAGELLAR ASSEMBLY
PROTEIN H,ENDOLYSIN
FLAGELLAR MOTOR
SWITCH PROTEIN
FLIM,FLAGELLAR MOTOR
SWITCH PROTEIN FLIN

(Escherichia
virus T4;
Salmonella
enterica;
Salmonella
enterica) 		PF00959
(Phage_lysozyme)
PF01052
(FliMN_C)
PF16973
(FliN_N) 		4 LEU B 179
ASP B 180
GLN B  72
VAL A  92
 None
 1.46A 6bzoF-4yxcB:
undetectable		 6bzoF-4yxcB:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo0 PROTEIN REP68

(Adeno-associated
dependoparvovirus
A) 		PF08724
(Rep_N) 		4 LEU A  45
ASP A  44
GLN A 162
VAL A  27
 None
 1.19A 6bzoF-4zo0A:
undetectable		 6bzoF-4zo0A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 LEU A 150
ASP A 149
GLN A 157
VAL A 282
 None
 1.12A 6bzoF-4zr0A:
2.6		 6bzoF-4zr0A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 LEU A 150
ASP A 149
GLN A 157
VAL A 282
 None
 1.24A 6bzoF-4zr1A:
2.7		 6bzoF-4zr1A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa6 VANADIUM-DEPENDENT
BROMOPEROXIDASE 2

(Ascophyllum
nodosum) 		no annotation 4 LEU A 167
ASP A  83
GLN A  93
VAL A 430
 None
 1.38A 6bzoF-5aa6A:
0.6		 6bzoF-5aa6A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT

(Azospira oryzae) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 LEU A 649
ASP A 648
GLN A 655
VAL A 577
 None
 1.15A 6bzoF-5chcA:
undetectable		 6bzoF-5chcA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h4r BETA-1,3-1,4-GLUCANA
SE

(Caldicellulosiruptor
sp. F32) 		PF00150
(Cellulase) 		4 LEU A 119
ASP A 120
GLN A 123
VAL A 220
 None
 1.11A 6bzoF-5h4rA:
undetectable		 6bzoF-5h4rA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixm LPS-ASSEMBLY PROTEIN
LPTD

(Yersinia pestis) 		PF04453
(OstA_C) 		4 LEU A 324
ASP A 304
GLN A 168
VAL A 211
 None
 1.45A 6bzoF-5ixmA:
undetectable		 6bzoF-5ixmA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila) 		PF00176
(SNF2_N)
PF00271
(Helicase_C) 		4 LEU A 161
ASP A 158
GLN A 459
VAL A 417
 None
 1.32A 6bzoF-5jxrA:
undetectable		 6bzoF-5jxrA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA

(Methylobacillus
flagellatus) 		PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		4 LEU C 403
ASP C  95
GLN C  85
VAL C 389
 None
 1.34A 6bzoF-5ks8C:
undetectable		 6bzoF-5ks8C:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldr BETA-D-GALACTOSIDASE

(Paracoccus sp.
32d) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 LEU B 103
ASP B 102
GLN B  70
VAL B  29
 None
PEG  B 803 ( 4.8A)
None
None
 1.34A 6bzoF-5ldrB:
undetectable		 6bzoF-5ldrB:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum) 		no annotation 4 LEU A 629
ASP A1182
GLN A1183
VAL A 812
 None
CA  A1501 (-3.3A)
None
None
 1.48A 6bzoF-5ngyA:
undetectable		 6bzoF-5ngyA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6v ENVELOPE PROTEIN

(Tick-borne
encephalitis
virus) 		no annotation 4 LEU A 194
ASP A 133
GLN A  50
VAL A  43
 None
 1.45A 6bzoF-5o6vA:
undetectable		 6bzoF-5o6vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogl UNDECAPRENYL-DIPHOSP
HOOLIGOSACCHARIDE--P
ROTEIN
GLYCOTRANSFERASE

(Campylobacter
lari) 		no annotation 4 LEU A 695
ASP A 692
GLN A 501
VAL A 531
 None
 1.46A 6bzoF-5oglA:
undetectable		 6bzoF-5oglA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tiz SULFOTRANSFERASE

(Schistosoma
japonicum) 		no annotation 4 LEU A  56
ASP A  57
GLN A  60
VAL A 123
 None
 1.24A 6bzoF-5tizA:
undetectable		 6bzoF-5tizA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ue8 PROTEIN UNC-13
HOMOLOG A

(Rattus
norvegicus) 		PF00130
(C1_1)
PF00168
(C2)
PF06292
(DUF1041)
PF10540
(Membr_traf_MHD) 		4 LEU A1361
ASP A1358
GLN A1362
VAL A1387
 None
 1.29A 6bzoF-5ue8A:
3.9		 6bzoF-5ue8A:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9w DNA MISMATCH REPAIR
PROTEIN MUTS

(Neisseria
gonorrhoeae) 		no annotation 4 LEU A 251
ASP A 252
GLN A 537
VAL A 107
 None
 1.39A 6bzoF-5x9wA:
1.9		 6bzoF-5x9wA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xse KHG/KDPG ALDOLASE

(Zymomonas
mobilis) 		no annotation 4 LEU A  75
ASP A  76
GLN A  79
VAL A 151
 None
 1.23A 6bzoF-5xseA:
undetectable		 6bzoF-5xseA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xse KHG/KDPG ALDOLASE

(Zymomonas
mobilis) 		no annotation 4 LEU A  75
ASP A  76
GLN A 102
VAL A 151
 None
 1.40A 6bzoF-5xseA:
undetectable		 6bzoF-5xseA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a8m -

(-) 		no annotation 4 LEU A 270
ASP A 269
GLN A 263
VAL A 421
 None
 1.45A 6bzoF-6a8mA:
undetectable		 6bzoF-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a8m -

(-) 		no annotation 4 LEU A 270
ASP A 269
GLN A 263
VAL A 430
 None
 1.38A 6bzoF-6a8mA:
undetectable		 6bzoF-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhu MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Bos taurus) 		no annotation 4 LEU A 236
ASP A 240
GLN A 230
VAL A1200
 None
 1.49A 6bzoF-6bhuA:
4.2		 6bzoF-6bhuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhu MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Bos taurus) 		no annotation 4 LEU A 236
ASP A 240
GLN A 230
VAL A1247
 None
 1.40A 6bzoF-6bhuA:
4.2		 6bzoF-6bhuA:
undetectable