SIMILAR PATTERNS OF AMINO ACIDS FOR 6BZO_C_FI8C1201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ee0 2-PYRONE SYNTHASE

(Gerbera hybrid
cultivar) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 ILE A 251
THR A 250
GLN A 249
THR A 174
VAL A 175
 None
 1.07A 6bzoC-1ee0A:
0.0		 6bzoC-1ee0A:
15.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ev1 ECHOVIRUS 1

(Enterovirus B) 		PF00073
(Rhv) 		5 THR 3  81
GLN 3  82
THR 3 192
VAL 3 191
VAL 3  71
 None
 1.12A 6bzoC-1ev13:
0.0		 6bzoC-1ev13:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ex0 COAGULATION FACTOR
XIII A CHAIN

(Homo sapiens) 		PF00868
(Transglut_N)
PF00927
(Transglut_C)
PF01841
(Transglut_core) 		5 THR A 688
GLN A 690
THR A 649
VAL A 648
VAL A 665
 None
 1.20A 6bzoC-1ex0A:
0.0		 6bzoC-1ex0A:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s9i DUAL SPECIFICITY
MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE 2

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 369
VAL A 337
GLU A 168
VAL A 377
GLU A 376
 None
 1.15A 6bzoC-1s9iA:
undetectable		 6bzoC-1s9iA:
15.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tmo TRIMETHYLAMINE
N-OXIDE REDUCTASE

(Shewanella
massilia) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		5 THR A 104
GLN A 103
VAL A 135
SER A  98
GLU A 462
 None
 1.28A 6bzoC-1tmoA:
0.0		 6bzoC-1tmoA:
22.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxt GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(NADP+)

(Thermoproteus
tenax) 		PF00171
(Aldedh) 		5 ILE A 340
THR A 165
VAL A 190
SER A 244
GLU A 395
 None
None
None
NAD  A1503 (-2.5A)
NAD  A1503 (-2.9A)
 1.27A 6bzoC-1uxtA:
0.0		 6bzoC-1uxtA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vho ENDOGLUCANASE

(Thermotoga
maritima) 		PF05343
(Peptidase_M42) 		5 THR A  42
VAL A 194
SER A 199
VAL A  66
GLU A  22
 THR  A  42 ( 0.8A)
VAL  A 194 ( 0.6A)
SER  A 199 (-0.0A)
VAL  A  66 ( 0.5A)
GLU  A  22 ( 0.6A)
 1.35A 6bzoC-1vhoA:
0.0		 6bzoC-1vhoA:
16.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xje RIBONUCLEOTIDE
REDUCTASE,
B12-DEPENDENT

(Thermotoga
maritima) 		PF00317
(Ribonuc_red_lgN)
PF02867
(Ribonuc_red_lgC) 		5 ILE A 625
THR A 319
VAL A 136
GLU A 324
GLU A 505
 None
None
None
GDP  A1002 (-2.6A)
None
 1.41A 6bzoC-1xjeA:
0.5		 6bzoC-1xjeA:
18.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xkw FE(III)-PYOCHELIN
RECEPTOR

(Pseudomonas
aeruginosa) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 ILE A 675
THR A 680
THR A 191
VAL A 205
VAL A 207
 None
 1.18A 6bzoC-1xkwA:
0.0		 6bzoC-1xkwA:
20.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ym0 FIBRINOTIC ENZYME
COMPONENT B

(Eisenia fetida) 		PF00089
(Trypsin) 		5 ILE A 144
THR A 143
VAL A  67
SER A 195
VAL A 213
 None
 1.40A 6bzoC-1ym0A:
undetectable		 6bzoC-1ym0A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zup HYPOTHETICAL PROTEIN
TM1739

(Thermotoga
maritima) 		PF09376
(NurA) 		5 ILE A  45
THR A 235
VAL A 215
VAL A 237
VAL A 219
 None
 1.31A 6bzoC-1zupA:
0.4		 6bzoC-1zupA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aa4 PUTATIVE
N-ACETYLMANNOSAMINE
KINASE

(Escherichia
coli) 		PF00480
(ROK) 		5 ILE A  67
GLN A 107
VAL A 138
VAL A 125
GLU A 289
 None
 1.37A 6bzoC-2aa4A:
undetectable		 6bzoC-2aa4A:
12.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bhm TYPE IV SECRETION
SYSTEM PROTEIN VIRB8

(Brucella suis) 		PF04335
(VirB8) 		5 ILE A 165
THR A 164
THR A 161
VAL A 159
GLU A 234
 None
 1.30A 6bzoC-2bhmA:
1.3		 6bzoC-2bhmA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ce9 TRANSDUCIN-LIKE
ENHANCER PROTEIN 1

(Homo sapiens) 		PF00400
(WD40) 		5 THR A 480
THR A 501
VAL A 507
SER A 758
VAL A 742
 None
 1.13A 6bzoC-2ce9A:
undetectable		 6bzoC-2ce9A:
15.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d39 FICOLIN-1

(Homo sapiens) 		PF00147
(Fibrinogen_C) 		5 VAL A 157
VAL A 144
GLU A 320
SER A 319
VAL A 318
 None
 1.40A 6bzoC-2d39A:
undetectable		 6bzoC-2d39A:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eg9 ADP-RIBOSYL CYCLASE
1

(Mus musculus) 		PF02267
(Rib_hydrolayse) 		5 ILE A 189
THR A 190
VAL A 114
SER A 197
GLU A 150
 None
 1.34A 6bzoC-2eg9A:
undetectable		 6bzoC-2eg9A:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vfw SHORT-CHAIN
Z-ISOPRENYL
DIPHOSPHATE
SYNTHETASE

(Mycobacterium
tuberculosis) 		PF01255
(Prenyltransf) 		5 THR A  81
VAL A  82
VAL A  37
VAL A 141
GLU A 142
 None
 1.24A 6bzoC-2vfwA:
undetectable		 6bzoC-2vfwA:
11.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xa7 ADAPTOR-RELATED
PROTEIN COMPLEX 2,
ALPHA 2 SUBUNIT
AP-2 COMPLEX SUBUNIT
BETA

(Rattus
norvegicus;
Homo sapiens) 		PF01602
(Adaptin_N)
PF01602
(Adaptin_N) 		5 ILE B 548
GLN A 577
VAL B 541
GLU A 575
VAL A 535
 None
 1.30A 6bzoC-2xa7B:
undetectable		 6bzoC-2xa7B:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z0v SH3-CONTAINING
GRB2-LIKE PROTEIN 3

(Homo sapiens) 		PF03114
(BAR) 		5 ILE A 117
GLN A 114
THR A  50
VAL A  51
SER A 107
 None
 1.30A 6bzoC-2z0vA:
undetectable		 6bzoC-2z0vA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z61 PROBABLE ASPARTATE
AMINOTRANSFERASE 2

(Methanocaldococcus
jannaschii) 		PF00155
(Aminotran_1_2) 		5 MET A  15
VAL A  31
VAL A 330
GLU A  25
SER A  26
 None
 1.28A 6bzoC-2z61A:
undetectable		 6bzoC-2z61A:
16.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a5r BENZALACETONE
SYNTHASE

(Rheum palmatum) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 ILE A 239
THR A 238
GLN A 237
THR A 162
VAL A 163
 None
 0.96A 6bzoC-3a5rA:
undetectable		 6bzoC-3a5rA:
16.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bex TYPE III
PANTOTHENATE KINASE

(Thermotoga
maritima) 		PF03309
(Pan_kinase) 		5 ILE A 145
THR A 131
VAL A 111
VAL A 114
LYS A 115
 PAU  A 248 ( 4.3A)
PAU  A 248 (-4.5A)
None
None
None
 1.29A 6bzoC-3bexA:
undetectable		 6bzoC-3bexA:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dff TEICOPLANIN
PSEUDOAGLYCONE
DEACETYLASES ORF2

(Actinoplanes
teichomyceticus) 		PF02585
(PIG-L) 		5 ILE A  13
THR A 154
THR A 264
GLU A 262
SER A  23
 None
 1.35A 6bzoC-3dffA:
undetectable		 6bzoC-3dffA:
12.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dfi PSEUDOAGLYCONE
DEACETYLASE DBV21

(Actinoplanes
teichomyceticus) 		PF02585
(PIG-L) 		5 ILE A  13
THR A 151
THR A 261
GLU A 259
SER A  23
 None
 1.40A 6bzoC-3dfiA:
undetectable		 6bzoC-3dfiA:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dkt MARITIMACIN

(Thermotoga
maritima) 		PF04454
(Linocin_M18) 		5 THR A 110
VAL A 111
VAL A 114
SER A 105
GLU A  91
 None
 1.12A 6bzoC-3dktA:
undetectable		 6bzoC-3dktA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e0g LEUKEMIA INHIBITORY
FACTOR RECEPTOR

(Homo sapiens) 		PF00041
(fn3) 		5 THR A 261
VAL A 275
VAL A 263
SER A 258
VAL A 311
 None
 1.40A 6bzoC-3e0gA:
undetectable		 6bzoC-3e0gA:
16.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f1c PUTATIVE
2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE
2

(Listeria
monocytogenes) 		PF01128
(IspD) 		5 ILE A 215
GLN A 166
THR A 136
VAL A 208
VAL A 134
 None
 1.39A 6bzoC-3f1cA:
undetectable		 6bzoC-3f1cA:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hjr EXTRACELLULAR SERINE
PROTEASE

(Aeromonas
sobria) 		PF00082
(Peptidase_S8)
PF01483
(P_proprotein) 		5 THR A 558
GLN A 560
THR A 573
SER A 514
VAL A 511
 None
 1.32A 6bzoC-3hjrA:
undetectable		 6bzoC-3hjrA:
19.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3a ACYL-[ACYL-CARRIER-P
ROTEIN]--UDP-N-ACETY
LGLUCOSAMINE
O-ACYLTRANSFERASE

(Leptospira
interrogans) 		PF00132
(Hexapep)
PF13720
(Acetyltransf_11) 		5 ILE A 106
THR A  37
VAL A  19
SER A  32
VAL A  31
 None
 1.20A 6bzoC-3i3aA:
undetectable		 6bzoC-3i3aA:
12.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ife PEPTIDASE T

(Bacillus
anthracis) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 ILE A 399
VAL A  13
LYS A  14
GLU A  42
VAL A  46
 None
 1.40A 6bzoC-3ifeA:
undetectable		 6bzoC-3ifeA:
16.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j4j TRANSLATION
INITIATION FACTOR
IF-2

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF04760
(IF2_N)
PF11987
(IF-2) 		5 ILE A 136
THR A 135
THR A 381
VAL A 432
VAL A  77
 None
 1.35A 6bzoC-3j4jA:
2.2		 6bzoC-3j4jA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kg6 CURF

(Lyngbya
majuscula) 		PF14765
(PS-DH) 		5 ILE A1927
THR A1926
GLN A1925
VAL A1751
GLU A1735
 None
 1.25A 6bzoC-3kg6A:
undetectable		 6bzoC-3kg6A:
14.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khs PURINE NUCLEOSIDE
PHOSPHORYLASE

(Singapore
grouper
iridovirus) 		PF01048
(PNP_UDP_1) 		5 MET A 127
ILE A 238
VAL A 272
VAL A 275
SER A 265
 None
 1.40A 6bzoC-3khsA:
undetectable		 6bzoC-3khsA:
12.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4g PHENYLALANYL-TRNA
SYNTHETASE ALPHA
CHAIN
PHENYLALANYL-TRNA
SYNTHETASE BETA
CHAIN

(Homo sapiens;
Homo sapiens) 		PF01409
(tRNA-synt_2d)
PF03483
(B3_4)
PF03484
(B5) 		5 ILE B 320
VAL A 419
SER A 416
VAL A 437
GLU A 414
 None
 1.35A 6bzoC-3l4gB:
undetectable		 6bzoC-3l4gB:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mfg V_SEGMENT
TRANSLATION PRODUCT

(Homo sapiens) 		PF07686
(V-set) 		5 ILE B  67
THR B  76
THR B 111
SER B   5
VAL B   4
 None
 1.24A 6bzoC-3mfgB:
undetectable		 6bzoC-3mfgB:
7.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmw ENDOGLUCANASE

(Thermotoga
maritima) 		PF00150
(Cellulase) 		5 ILE A 249
THR A 194
THR A 165
GLU A 188
VAL A 184
 None
 1.21A 6bzoC-3mmwA:
undetectable		 6bzoC-3mmwA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n0q PUTATIVE
AROMATIC-RING
HYDROXYLATING
DIOXYGENASE

(Ruegeria sp.
TM1040) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		5 GLN A  60
VAL A  57
GLU A 323
VAL A 184
GLU A 321
 None
 1.40A 6bzoC-3n0qA:
undetectable		 6bzoC-3n0qA:
15.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ndo DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Mycolicibacterium
smegmatis) 		PF01791
(DeoC) 		5 ILE A 129
THR A 163
VAL A  42
SER A  45
GLU A  81
 None
 1.38A 6bzoC-3ndoA:
undetectable		 6bzoC-3ndoA:
12.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nwr A RUBISCO-LIKE
PROTEIN

(Paraburkholderia
fungorum) 		PF00016
(RuBisCO_large)
PF02788
(RuBisCO_large_N) 		5 THR A 113
GLN A  38
VAL A  33
VAL A  30
SER A  40
 None
 1.37A 6bzoC-3nwrA:
undetectable		 6bzoC-3nwrA:
18.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ojl CAP5O

(Staphylococcus
aureus) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 MET A 192
ILE A 169
GLU A 207
SER A 203
GLU A 201
 None
 1.20A 6bzoC-3ojlA:
undetectable		 6bzoC-3ojlA:
16.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qfv CDC42BPB PROTEIN

(Homo sapiens) 		PF00069
(Pkinase) 		5 ILE A 321
GLN A 318
GLU A 311
SER A 310
VAL A 309
 None
 1.39A 6bzoC-3qfvA:
undetectable		 6bzoC-3qfvA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r6h ENOYL-COA HYDRATASE,
ECHA3

(Mycobacterium
marinum) 		PF00378
(ECH_1) 		5 ILE A 178
VAL A  50
VAL A  96
SER A 186
GLU A 182
 None
 1.12A 6bzoC-3r6hA:
undetectable		 6bzoC-3r6hA:
12.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rf7 IRON-CONTAINING
ALCOHOL
DEHYDROGENASE

(Shewanella
denitrificans) 		PF00465
(Fe-ADH) 		5 ILE A 197
THR A 325
VAL A 324
VAL A 322
VAL A 153
 None
None
None
None
NAD  A 358 (-4.2A)
 1.31A 6bzoC-3rf7A:
0.1		 6bzoC-3rf7A:
14.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tfx OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Lactobacillus
acidophilus) 		PF00215
(OMPdecase) 		5 ILE A  57
THR A  83
THR A  86
VAL A  87
VAL A 119
 None
 1.31A 6bzoC-3tfxA:
undetectable		 6bzoC-3tfxA:
12.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u6n HIGH-CONDUCTANCE
CA2+-ACTIVATED K+
CHANNEL PROTEIN

(Danio rerio) 		PF02254
(TrkA_N)
PF03493
(BK_channel_a) 		5 ILE A 424
THR A 458
GLN A 459
VAL A 921
VAL A 923
 None
 1.25A 6bzoC-3u6nA:
undetectable		 6bzoC-3u6nA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9f TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE/RESPONSE
REGULATOR, HYBRID
(ONE-COMPONENT
SYSTEM)

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		5 ILE A 527
VAL A 498
LYS A 496
GLU A 460
VAL A 469
 None
 1.38A 6bzoC-3v9fA:
undetectable		 6bzoC-3v9fA:
20.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vkw REPLICASE LARGE
SUBUNIT

(Tobacco mosaic
virus) 		PF01443
(Viral_helicase1) 		5 GLN A1022
THR A1038
VAL A1039
VAL A1042
VAL A1060
 SO4  A1204 (-3.8A)
SO4  A1204 (-3.3A)
None
None
None
 1.20A 6bzoC-3vkwA:
undetectable		 6bzoC-3vkwA:
16.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wqy ALANINE--TRNA LIGASE

(Archaeoglobus
fulgidus) 		PF01411
(tRNA-synt_2c)
PF02272
(DHHA1)
PF07973
(tRNA_SAD) 		5 ILE A 300
THR A 319
VAL A 320
VAL A 331
GLU A 335
 None
 1.10A 6bzoC-3wqyA:
undetectable		 6bzoC-3wqyA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4akz TYPE IV SECRETION
SYSTEM PROTEIN VIRB8

(Brucella suis) 		PF04335
(VirB8) 		5 ILE A 165
THR A 164
THR A 161
VAL A 159
GLU A 234
 None
 1.30A 6bzoC-4akzA:
1.9		 6bzoC-4akzA:
8.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgt CYCLODEXTRIN
GLYCOSYLTRANSFERASE

(Bacillus
circulans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		5 THR A 546
GLN A 547
THR A 515
VAL A 514
VAL A 564
 None
 1.24A 6bzoC-4cgtA:
undetectable		 6bzoC-4cgtA:
19.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d6v G PROTEIN BETA
SUBUNIT GIB2

(Cryptococcus
neoformans) 		PF00400
(WD40) 		5 ILE A 236
THR A 252
VAL A 307
VAL A 309
SER A 303
 None
 1.14A 6bzoC-4d6vA:
undetectable		 6bzoC-4d6vA:
14.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dsh UDP-GALACTOPYRANOSE
MUTASE

(Trypanosoma
cruzi) 		PF01593
(Amino_oxidase)
PF13450
(NAD_binding_8) 		5 ILE A  12
VAL A 458
VAL A 431
GLU A 455
VAL A 448
 FDA  A 502 (-4.6A)
None
None
None
None
 1.37A 6bzoC-4dshA:
undetectable		 6bzoC-4dshA:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e84 D-BETA-D-HEPTOSE
7-PHOSPHATE KINASE

(Burkholderia
cenocepacia) 		PF00294
(PfkB) 		5 ILE A 299
THR A 278
VAL A  20
VAL A   7
GLU A   6
 None
 1.31A 6bzoC-4e84A:
undetectable		 6bzoC-4e84A:
15.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4esj TYPE-2 RESTRICTION
ENZYME DPNI

(Streptococcus
pneumoniae) 		PF06044
(DpnI) 		5 ILE A 192
THR A 189
THR A 119
VAL A 118
VAL A  88
 None
 1.30A 6bzoC-4esjA:
undetectable		 6bzoC-4esjA:
11.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ex4 MALATE SYNTHASE G

(Mycobacterium
leprae) 		PF01274
(Malate_synthase) 		5 ILE A 644
THR A 641
VAL A 118
VAL A 547
GLU A 716
 None
 1.39A 6bzoC-4ex4A:
undetectable		 6bzoC-4ex4A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f9o HEXOKINASE-1

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 THR A 821
VAL A 822
VAL A 825
SER A 816
GLU A 252
 None
 1.29A 6bzoC-4f9oA:
undetectable		 6bzoC-4f9oA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fn7 ENOYL-COA
HYDRATASE/ISOMERASE
FAMILY PROTEIN

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		5 ILE A 178
VAL A  50
VAL A  96
SER A 186
GLU A 182
 None
 1.16A 6bzoC-4fn7A:
undetectable		 6bzoC-4fn7A:
11.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fxg MANNAN-BINDING
LECTIN SERINE
PROTEASE 2 A CHAIN

(Homo sapiens) 		PF00084
(Sushi) 		5 THR G 419
VAL G 411
LYS G 409
VAL G 364
GLU G 333
 None
 1.02A 6bzoC-4fxgG:
undetectable		 6bzoC-4fxgG:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcl CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Paenibacillus
macerans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		5 THR A 548
GLN A 549
THR A 517
VAL A 516
VAL A 566
 None
 1.20A 6bzoC-4jclA:
undetectable		 6bzoC-4jclA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgi PUTATIVE
UNCHARACTERIZED
PROTEIN

(Desulfitobacterium
hafniense) 		PF02310
(B12-binding)
PF02607
(B12-binding_2) 		5 ILE A 108
THR A  96
VAL A  97
VAL A 127
VAL A 182
 COB  A 301 ( 4.1A)
None
None
None
None
 1.21A 6bzoC-4jgiA:
undetectable		 6bzoC-4jgiA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kjr CATION EXCHANGER
YFKE

(Bacillus
subtilis) 		PF01699
(Na_Ca_ex) 		5 ILE A 215
THR A 214
VAL A 250
VAL A 247
VAL A   9
 None
 1.40A 6bzoC-4kjrA:
undetectable		 6bzoC-4kjrA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kt7 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Anaerococcus
prevotii) 		PF01128
(IspD) 		5 ILE A 213
GLN A 163
THR A 133
VAL A 205
VAL A 131
 None
 1.30A 6bzoC-4kt7A:
undetectable		 6bzoC-4kt7A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kt7 2-C-METHYL-D-ERYTHRI
TOL 4-PHOSPHATE
CYTIDYLYLTRANSFERASE

(Anaerococcus
prevotii) 		PF01128
(IspD) 		5 ILE A 213
GLN A 163
THR A 133
VAL A 206
VAL A 131
 None
 1.31A 6bzoC-4kt7A:
undetectable		 6bzoC-4kt7A:
11.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l4u TRANSCRIPTIONAL
REGULATOR (NTRC
FAMILY)

(Aquifex
aeolicus) 		PF00072
(Response_reg)
PF00158
(Sigma54_activat) 		5 ILE A 108
VAL A  -5
SER A  21
VAL A  27
GLU A  17
 None
 1.26A 6bzoC-4l4uA:
undetectable		 6bzoC-4l4uA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n6r VELB

(Aspergillus
nidulans) 		PF11754
(Velvet) 		5 ILE B  68
THR B  84
VAL B 114
SER B 266
VAL B 267
 None
 1.38A 6bzoC-4n6rB:
undetectable		 6bzoC-4n6rB:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nk7 SERINE/THREONINE-PRO
TEIN KINASE PLK4

(Drosophila
melanogaster) 		no annotation 5 GLN A 459
VAL A 456
GLU A 417
VAL A 415
GLU A 413
 None
 1.02A 6bzoC-4nk7A:
undetectable		 6bzoC-4nk7A:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o9d RIK1-ASSOCIATED
FACTOR 1

(Schizosaccharomyces
pombe) 		no annotation 5 ILE B 491
THR B 563
VAL B 570
VAL B 572
SER B 566
 None
 1.32A 6bzoC-4o9dB:
undetectable		 6bzoC-4o9dB:
16.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozi T-CELL RECEPTOR, S2,
BETA CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		5 ILE F  78
THR F  88
THR F 120
SER F   5
VAL F   4
 None
 1.20A 6bzoC-4oziF:
undetectable		 6bzoC-4oziF:
12.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p05 ARYLSULFATE
SULFOTRANSFERASE
ASST

(Escherichia
coli) 		PF05935
(Arylsulfotrans)
PF17425
(Arylsulfotran_N) 		5 ILE A 173
THR A 139
THR A 529
VAL A 530
VAL A 135
 None
 1.30A 6bzoC-4p05A:
undetectable		 6bzoC-4p05A:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pfz 5-CARBOXYMETHYL-2-HY
DROXYMUCONATE
DELTA-ISOMERASE

(Mycolicibacterium
smegmatis) 		PF01557
(FAA_hydrolase)
PF10370
(DUF2437) 		5 ILE A 192
THR A 159
THR A 245
VAL A  84
VAL A 201
 None
 1.20A 6bzoC-4pfzA:
undetectable		 6bzoC-4pfzA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r5q CRISPR-ASSOCIATED
EXONUCLEASE, CAS4
FAMILY

(Pyrobaculum
calidifontis) 		PF01930
(Cas_Cas4) 		5 THR A 148
GLN A 149
VAL A 113
VAL A 119
SER A 155
 None
 1.32A 6bzoC-4r5qA:
undetectable		 6bzoC-4r5qA:
11.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rvo PHENYLACETATE-COENZY
ME A LIGASE

(Bacteroides
thetaiotaomicron) 		PF00501
(AMP-binding)
PF14535
(AMP-binding_C_2) 		5 ILE A 225
VAL A 159
SER A 166
VAL A 194
GLU A 193
 None
None
SO4  A 508 (-2.6A)
None
None
 1.29A 6bzoC-4rvoA:
undetectable		 6bzoC-4rvoA:
17.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4udr GLUCOSE-METHANOL-CHO
LINE OXIDOREDUCTASE

(Methylovorus
sp. MP688) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 ILE A  46
THR A  41
VAL A 219
VAL A 221
SER A  18
 None
 1.14A 6bzoC-4udrA:
undetectable		 6bzoC-4udrA:
20.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyi KINETOCHORE PROTEIN
MIS16

(Schizosaccharomyces
japonicus) 		PF00400
(WD40)
PF12265
(CAF1C_H4-bd) 		5 THR A 317
THR A 340
VAL A 347
SER A 298
VAL A 281
 None
 1.27A 6bzoC-4xyiA:
undetectable		 6bzoC-4xyiA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yfa PROTEIN RELATED TO
PENICILLIN ACYLASE

(Acidovorax sp.
MR-S7) 		PF01804
(Penicil_amidase) 		5 THR C 523
GLN C 510
VAL C  64
SER C 333
VAL C 336
 None
 1.25A 6bzoC-4yfaC:
0.3		 6bzoC-4yfaC:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yjy CHALCONE SYNTHASE 1

(Oryza sativa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 ILE A 249
GLN A 247
THR A 172
VAL A 173
VAL A 176
 None
 1.08A 6bzoC-4yjyA:
undetectable		 6bzoC-4yjyA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yjy CHALCONE SYNTHASE 1

(Oryza sativa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		5 ILE A 249
THR A 248
GLN A 247
THR A 172
VAL A 176
 None
 0.97A 6bzoC-4yjyA:
undetectable		 6bzoC-4yjyA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a42 UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF11974
(MG1) 		5 ILE A1098
THR A1620
VAL A1619
VAL A1651
GLU A1024
 None
 1.30A 6bzoC-5a42A:
undetectable		 6bzoC-5a42A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bu9 BETA-N-ACETYLHEXOSAM
INIDASE

(Beutenbergia
cavernae) 		PF00933
(Glyco_hydro_3) 		5 VAL A 377
VAL A 380
SER A 371
VAL A  95
GLU A  93
 None
 1.35A 6bzoC-5bu9A:
undetectable		 6bzoC-5bu9A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9i PROTEIN RELATED TO
PENICILLIN ACYLASE

(Acidovorax sp.
MR-S7) 		PF01804
(Penicil_amidase) 		5 THR A 725
GLN A 712
VAL A 266
SER A 535
VAL A 538
 None
 1.30A 6bzoC-5c9iA:
undetectable		 6bzoC-5c9iA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cuz METHYLMALONIC
ACIDURIA AND
HOMOCYSTINURIA TYPE
D PROTEIN,
MITOCHONDRIAL

(Homo sapiens) 		PF10229
(MMADHC) 		5 THR A 152
GLN A 151
THR A 177
VAL A 178
VAL A 276
 None
 1.26A 6bzoC-5cuzA:
undetectable		 6bzoC-5cuzA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eb5 HNL ISOENZYME 5

(Prunus dulcis) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 ILE A 261
THR A 260
VAL A  31
VAL A 254
SER A  37
 None
None
None
None
FAD  A 601 (-4.4A)
 1.19A 6bzoC-5eb5A:
undetectable		 6bzoC-5eb5A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7s GLYCOSIDE HYDROLASE
FAMILY 31

(Trueperella
pyogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		5 GLN A 388
VAL A 328
VAL A 384
SER A 515
GLU A 470
 None
 1.35A 6bzoC-5f7sA:
undetectable		 6bzoC-5f7sA:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gl7 METHIONINE--TRNA
LIGASE, CYTOPLASMIC

(Homo sapiens) 		PF09334
(tRNA-synt_1g) 		5 THR A 359
GLN A 362
THR A 503
VAL A 514
VAL A 505
 None
 1.35A 6bzoC-5gl7A:
undetectable		 6bzoC-5gl7A:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lq3 CMEB

(Campylobacter
jejuni) 		PF00873
(ACR_tran) 		5 THR A 924
GLN A 923
VAL A 557
SER A 907
VAL A 904
 None
 1.22A 6bzoC-5lq3A:
undetectable		 6bzoC-5lq3A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mpo MOLYBDOPTERIN
SYNTHASE SULFUR
CARRIER SUBUNIT

(Homo sapiens) 		PF02597
(ThiS) 		5 ILE A  82
THR A  19
GLU A  24
SER A  23
GLU A  78
 None
 1.36A 6bzoC-5mpoA:
undetectable		 6bzoC-5mpoA:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tv2 ELONGATION FACTOR G

(Vibrio
vulnificus) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2) 		5 ILE A 322
THR A 390
THR A 394
VAL A 402
GLU A  98
 None
 1.37A 6bzoC-5tv2A:
undetectable		 6bzoC-5tv2A:
15.88
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		7 MET C1042
ILE C1043
THR C1044
GLN C1045
THR C1087
VAL C1088
VAL C1091
 None
 0.93A 6bzoC-5tw1C:
43.8		 6bzoC-5tw1C:
90.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5tw1 DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA

(Mycolicibacterium
smegmatis) 		PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF10385
(RNA_pol_Rpb2_45) 		5 VAL C1091
GLU C1110
SER C1111
VAL C1114
GLU C1118
 None
 1.14A 6bzoC-5tw1C:
43.8		 6bzoC-5tw1C:
90.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uco 2,4,6-TRIHYDROXYBENZ
OPHENONE SYNTHASE

(Hypericum
androsaemum) 		no annotation 5 ILE A 250
THR A 249
GLN A 248
THR A 172
VAL A 176
 None
 1.06A 6bzoC-5ucoA:
undetectable		 6bzoC-5ucoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8l PGT145 ANTIBODY,
LIGHT CHAIN

(Homo sapiens) 		PF07686
(V-set) 		5 ILE N   4
THR N   5
GLN N   6
THR N 102
VAL N 104
 None
 1.37A 6bzoC-5v8lN:
undetectable		 6bzoC-5v8lN:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vg2 INTRADIOL
RING-CLEAVAGE
DIOXYGENASE

(Tetranychus
urticae) 		no annotation 5 ILE U  74
THR U 144
GLN U 145
GLU U 156
GLU U  80
 None
 1.37A 6bzoC-5vg2U:
undetectable		 6bzoC-5vg2U:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wq3 CYTOKININ RIBOSIDE
5'-MONOPHOSPHATE
PHOSPHORIBOHYDROLASE

(Corynebacterium
glutamicum) 		PF03641
(Lysine_decarbox) 		5 THR A 157
THR A  72
VAL A  71
VAL A 103
VAL A 191
 None
 1.37A 6bzoC-5wq3A:
undetectable		 6bzoC-5wq3A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x3j GLYCOSIDE HYDROLASE
FAMILY 31

(Kribbella
flavida) 		no annotation 5 GLN A 373
VAL A 312
VAL A 369
SER A 499
GLU A 454
 None
 1.37A 6bzoC-5x3jA:
undetectable		 6bzoC-5x3jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yxg PILUS ASSEMBLY
PROTEIN

(Lactobacillus
rhamnosus) 		no annotation 5 THR A 211
GLN A 213
THR A 318
VAL A 317
VAL A 259
 None
 1.33A 6bzoC-5yxgA:
undetectable		 6bzoC-5yxgA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z3r STEROID
DELTA-ISOMERASE

(Mycolicibacterium
neoaurum) 		no annotation 5 THR A 140
VAL A 108
GLU A 100
VAL A  98
GLU A  82
 None
 1.35A 6bzoC-5z3rA:
1.4		 6bzoC-5z3rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a91 -

(-) 		no annotation 5 ILE A 152
THR A 149
THR A 237
VAL A 238
VAL A 241
 None
 1.25A 6bzoC-6a91A:
undetectable		 6bzoC-6a91A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aqo HYPOXANTHINE-GUANINE
PHOSPHORIBOSYLTRANSF
ERASE

(Trypanosoma
brucei) 		no annotation 5 THR A 196
VAL A 178
VAL A 193
VAL A 221
GLU A  31
 None
 1.26A 6bzoC-6aqoA:
undetectable		 6bzoC-6aqoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cfw MEMBRANE-BOUND
HYDROGENASE SUBUNIT
BETA
MEMBRANE-BOUND
HYDROGENASE SUBUNIT
ALPHA

(Pyrococcus
furiosus;
Pyrococcus
furiosus) 		no annotation
no annotation 		5 THR K  24
VAL K   7
LYS K  10
SER K  86
GLU L 234
 None
 1.27A 6bzoC-6cfwK:
undetectable		 6bzoC-6cfwK:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6co0 STYRYLPYRONE
SYNTHASE 1

(Piper
methysticum) 		no annotation 5 ILE A 247
THR A 246
GLN A 245
THR A 169
VAL A 170
 None
 1.06A 6bzoC-6co0A:
undetectable		 6bzoC-6co0A:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5uhe DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA'

(Mycobacterium
tuberculosis) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4) 		5 ARG D  84
GLU D 323
LEU D 324
PRO D 326
SER D 338
 None
 1.01A 6bzoD-5uheD:
32.8		 6bzoD-5uheD:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h17 FORMATE
ACETYLTRANSFERASE 1

(Escherichia
coli) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		4 LEU A 343
ASP A 344
GLN A  30
VAL A 420
 None
 1.21A 6bzoF-1h17A:
0.0		 6bzoF-1h17A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kpi CYCLOPROPANE-FATTY-A
CYL-PHOSPHOLIPID
SYNTHASE 2

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		4 LEU A  35
ASP A  36
GLN A  57
VAL A  17
 None
 1.23A 6bzoF-1kpiA:
0.0		 6bzoF-1kpiA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1krh BENZOATE
1,2-DIOXYGENASE
REDUCTASE

(Acinetobacter
sp.) 		PF00111
(Fer2)
PF00175
(NAD_binding_1)
PF00970
(FAD_binding_6) 		4 LEU A 259
ASP A 260
GLN A 263
VAL A 313
 None
 1.31A 6bzoF-1krhA:
undetectable		 6bzoF-1krhA:
18.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p9n MOLYBDOPTERIN-GUANIN
E DINUCLEOTIDE
BIOSYNTHESIS PROTEIN
B

(Escherichia
coli) 		PF03205
(MobB) 		4 LEU A  85
ASP A  84
GLN A  86
VAL A 136
 None
 1.48A 6bzoF-1p9nA:
undetectable		 6bzoF-1p9nA:
17.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjm LACTOFERRIN

(Equus caballus) 		PF00405
(Transferrin) 		4 LEU A 318
ASP A 315
GLN A 313
VAL A 410
 None
 1.23A 6bzoF-1qjmA:
0.0		 6bzoF-1qjmA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w18 LEVANSUCRASE

(Gluconacetobacter
diazotrophicus) 		PF02435
(Glyco_hydro_68) 		4 LEU A 462
ASP A 461
GLN A 476
VAL A 359
 None
 1.49A 6bzoF-1w18A:
undetectable		 6bzoF-1w18A:
20.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl4 ACETYL-COENZYME A
ACETYLTRANSFERASE 2

(Homo sapiens) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 LEU A 351
ASP A 219
GLN A 193
VAL A 315
 None
 1.48A 6bzoF-1wl4A:
0.0		 6bzoF-1wl4A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytu HYPOTHETICAL PROTEIN
AF1318

(Archaeoglobus
fulgidus) 		PF02171
(Piwi) 		4 LEU A 157
ASP A 154
GLN A  67
VAL A 100
 None
 1.40A 6bzoF-1ytuA:
0.0		 6bzoF-1ytuA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaz THYMIDYLATE SYNTHASE

(Cryptococcus
neoformans) 		PF00303
(Thymidylat_synt) 		4 LEU A 153
ASP A 151
GLN A 154
VAL A 301
 None
 1.42A 6bzoF-2aazA:
undetectable		 6bzoF-2aazA:
18.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h84 STEELY1

(Dictyostelium
discoideum) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 LEU A3030
ASP A2971
GLN A2972
VAL A2896
 P6G  A1000 ( 4.4A)
P6G  A1000 (-3.3A)
None
None
 1.43A 6bzoF-2h84A:
undetectable		 6bzoF-2h84A:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hhz PYRIDOXAMINE
5'-PHOSPHATE
OXIDASE-RELATED

(Streptococcus
suis) 		PF01243
(Putative_PNPOx) 		4 LEU A  21
ASP A  22
GLN A  55
VAL A  76
 None
None
PO4  A 150 ( 4.4A)
None
 1.44A 6bzoF-2hhzA:
undetectable		 6bzoF-2hhzA:
14.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ixo SERINE/THREONINE-PRO
TEIN PHOSPHATASE 2A
ACTIVATOR 1

(Saccharomyces
cerevisiae) 		PF03095
(PTPA) 		4 LEU A 105
ASP A 106
GLN A 129
VAL A 211
 None
 1.20A 6bzoF-2ixoA:
undetectable		 6bzoF-2ixoA:
19.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jam CALCIUM/CALMODULIN-D
EPENDENT PROTEIN
KINASE TYPE 1G

(Homo sapiens) 		PF00069
(Pkinase) 		4 LEU A 273
ASP A 279
GLN A 126
VAL A  72
 None
 1.34A 6bzoF-2jamA:
undetectable		 6bzoF-2jamA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nyf NOSTOC PUNCTIFORME
PHENYLALANINE
AMMONIA LYASE

(Nostoc
punctiforme) 		PF00221
(Lyase_aromatic) 		4 LEU A 242
ASP A 238
GLN A 473
VAL A 487
 None
 1.49A 6bzoF-2nyfA:
1.2		 6bzoF-2nyfA:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obe HEXON

(Human
mastadenovirus
E) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		4 LEU A 688
ASP A 689
GLN A 352
VAL A  81
 None
 1.39A 6bzoF-2obeA:
undetectable		 6bzoF-2obeA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsj SULFITE REDUCTASE
ALPHA SUBUNIT

(Desulfomicrobium
norvegicum) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		4 LEU A   9
ASP A  10
GLN A  13
VAL A 140
 None
 1.47A 6bzoF-2xsjA:
undetectable		 6bzoF-2xsjA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yoc PULLULANASE

(Klebsiella
oxytoca) 		PF02922
(CBM_48)
PF03714
(PUD)
PF11852
(DUF3372) 		4 LEU A 245
ASP A 242
GLN A 246
VAL A 626
 None
SO4  A2078 (-4.4A)
SO4  A2078 (-3.5A)
None
 1.32A 6bzoF-2yocA:
undetectable		 6bzoF-2yocA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bhw UNCHARACTERIZED
PROTEIN

(Magnetospirillum
magneticum) 		PF08849
(DUF1819) 		4 LEU A 170
ASP A 117
GLN A 110
VAL A  88
 None
 1.45A 6bzoF-3bhwA:
undetectable		 6bzoF-3bhwA:
17.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cj1 ECTONUCLEOSIDE
TRIPHOSPHATE
DIPHOSPHOHYDROLASE 2

(Rattus
norvegicus) 		PF01150
(GDA1_CD39) 		4 LEU A 202
ASP A 201
GLN A 208
VAL A 279
 None
 1.43A 6bzoF-3cj1A:
undetectable		 6bzoF-3cj1A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g64 PUTATIVE ENOYL-COA
HYDRATASE

(Streptomyces
coelicolor) 		PF00378
(ECH_1) 		4 LEU A 228
ASP A 244
GLN A 248
VAL A  60
 None
 1.41A 6bzoF-3g64A:
undetectable		 6bzoF-3g64A:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hmu AMINOTRANSFERASE,
CLASS III

(Ruegeria
pomeroyi) 		PF00202
(Aminotran_3) 		4 LEU A 447
ASP A 448
GLN A 451
VAL A 238
 None
 1.15A 6bzoF-3hmuA:
undetectable		 6bzoF-3hmuA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hxl UNCHARACTERIZED
PROTEIN DSY3957

(Desulfitobacterium
hafniense) 		PF04984
(Phage_sheath_1)
PF17481
(Phage_sheath_1N)
PF17482
(Phage_sheath_1C) 		4 LEU A  72
ASP A  69
GLN A  71
VAL A 234
 None
 1.40A 6bzoF-3hxlA:
undetectable		 6bzoF-3hxlA:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i3v PROBABLE SECRETED
SOLUTE-BINDING
LIPOPROTEIN

(Streptomyces
coelicolor) 		PF01547
(SBP_bac_1) 		4 LEU A  83
ASP A  82
GLN A  85
VAL A 148
 None
 1.33A 6bzoF-3i3vA:
undetectable		 6bzoF-3i3vA:
22.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lqz HLA CLASS II
HISTOCOMPATIBILITY
ANTIGEN, DP ALPHA 1
CHAIN

(Homo sapiens) 		PF00993
(MHC_II_alpha)
PF07654
(C1-set) 		4 LEU A 170
ASP A 171
GLN A 172
VAL A 132
 None
 1.44A 6bzoF-3lqzA:
undetectable		 6bzoF-3lqzA:
16.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n6r PROPIONYL-COA
CARBOXYLASE, ALPHA
SUBUNIT
PROPIONYL-COA
CARBOXYLASE, BETA
SUBUNIT

(Ruegeria
pomeroyi;
Roseobacter
denitrificans) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2)
PF01039
(Carboxyl_trans) 		4 LEU B 362
ASP B 367
GLN B 403
VAL A 723
 None
 1.03A 6bzoF-3n6rB:
undetectable		 6bzoF-3n6rB:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sgi DNA LIGASE

(Mycobacterium
tuberculosis) 		PF01653
(DNA_ligase_aden)
PF03120
(DNA_ligase_OB) 		4 LEU A 119
ASP A 302
GLN A 307
VAL A 185
 None
 1.34A 6bzoF-3sgiA:
2.3		 6bzoF-3sgiA:
26.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3syj ADHESION AND
PENETRATION PROTEIN
AUTOTRANSPORTER

(Haemophilus
influenzae) 		PF02395
(Peptidase_S6)
PF03212
(Pertactin) 		4 LEU A 793
ASP A 813
GLN A 811
VAL A 742
 None
 1.38A 6bzoF-3syjA:
undetectable		 6bzoF-3syjA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a5w COMPLEMENT C5

(Homo sapiens) 		PF00207
(A2M)
PF01759
(NTR)
PF01835
(A2M_N)
PF07677
(A2M_recep)
PF07678
(A2M_comp)
PF07703
(A2M_N_2) 		4 LEU A 379
ASP A 377
GLN A 381
VAL A 612
 None
 1.49A 6bzoF-4a5wA:
3.1		 6bzoF-4a5wA:
16.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aod ACETYLCHOLINE-BINDIN
G PROTEIN TYPE 1

(Biomphalaria
glabrata) 		PF02931
(Neur_chan_LBD) 		4 LEU A  37
ASP A 165
GLN A  38
VAL A  45
 None
 1.34A 6bzoF-4aodA:
undetectable		 6bzoF-4aodA:
17.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dj2 PERIOD CIRCADIAN
PROTEIN HOMOLOG 1

(Mus musculus) 		PF08447
(PAS_3) 		4 LEU A 384
ASP A 387
GLN A 261
VAL A 240
 None
 1.31A 6bzoF-4dj2A:
undetectable		 6bzoF-4dj2A:
20.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dwq TRNA-SPLICING LIGASE
RTCB

(Pyrococcus
horikoshii) 		PF01139
(RtcB) 		4 LEU A 268
ASP A 265
GLN A  46
VAL A 334
 None
 1.36A 6bzoF-4dwqA:
0.8		 6bzoF-4dwqA:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e9k HYPOTHETICAL PROTEIN

(Bacteroides
ovatus) 		PF14717
(DUF4465) 		4 LEU A 215
ASP A 216
GLN A 217
VAL A 157
 None
 1.49A 6bzoF-4e9kA:
undetectable		 6bzoF-4e9kA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g56 HSL7 PROTEIN

(Xenopus laevis) 		PF05185
(PRMT5)
PF17285
(PRMT5_TIM)
PF17286
(PRMT5_C) 		4 LEU A 129
ASP A  88
GLN A 123
VAL A  15
 None
 1.44A 6bzoF-4g56A:
undetectable		 6bzoF-4g56A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ikv DI-TRIPEPTIDE ABC
TRANSPORTER
(PERMEASE)

(Geobacillus
kaustophilus) 		PF00854
(PTR2) 		4 LEU A 326
ASP A 327
GLN A 325
VAL A 410
 None
 1.50A 6bzoF-4ikvA:
2.4		 6bzoF-4ikvA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q73 PROLINE
DEHYDROGENASE

(Bradyrhizobium
diazoefficiens) 		PF00171
(Aldedh)
PF01619
(Pro_dh)
PF14850
(Pro_dh-DNA_bdg) 		4 LEU A 264
ASP A 263
GLN A 260
VAL A 168
 None
 1.37A 6bzoF-4q73A:
3.0		 6bzoF-4q73A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tnm IMPORTIN SUBUNIT
ALPHA

(Arabidopsis
thaliana) 		PF00514
(Arm)
PF01749
(IBB)
PF16186
(Arm_3) 		4 LEU A 326
ASP A 327
GLN A 329
VAL A 378
 None
 1.30A 6bzoF-4tnmA:
2.5		 6bzoF-4tnmA:
22.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u10 POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE

(Aggregatibacter
actinomycetemcomitans) 		PF01522
(Polysacc_deac_1) 		4 LEU A 128
ASP A 129
GLN A 222
VAL A  94
 None
 1.45A 6bzoF-4u10A:
undetectable		 6bzoF-4u10A:
18.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u33 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF11896
(DUF3416) 		4 LEU A 396
ASP A 392
GLN A 361
VAL A 317
 None
 1.14A 6bzoF-4u33A:
undetectable		 6bzoF-4u33A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uaq PROTEIN TRANSLOCASE
SUBUNIT SECA 2

(Mycobacterium
tuberculosis) 		PF01043
(SecA_PP_bind)
PF07516
(SecA_SW)
PF07517
(SecA_DEAD) 		4 LEU A 594
ASP A 595
GLN A 598
VAL A 432
 None
 1.27A 6bzoF-4uaqA:
undetectable		 6bzoF-4uaqA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uop LIPOTEICHOIC ACID
PRIMASE

(Listeria
monocytogenes) 		PF00884
(Sulfatase) 		4 LEU A 257
ASP A 258
GLN A 261
VAL A 274
 None
 0.95A 6bzoF-4uopA:
undetectable		 6bzoF-4uopA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y21 PROTEIN UNC-13
HOMOLOG A

(Rattus
norvegicus) 		PF06292
(DUF1041)
PF10540
(Membr_traf_MHD) 		4 LEU A 429
ASP A 426
GLN A 430
VAL A 455
 None
 1.36A 6bzoF-4y21A:
3.2		 6bzoF-4y21A:
22.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yke MRE11

(Chaetomium
thermophilum) 		PF00149
(Metallophos)
PF04152
(Mre11_DNA_bind) 		4 LEU A 137
ASP A 138
GLN A 141
VAL A 237
 None
 0.87A 6bzoF-4ykeA:
undetectable		 6bzoF-4ykeA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yxc FLAGELLAR ASSEMBLY
PROTEIN H,ENDOLYSIN
FLAGELLAR MOTOR
SWITCH PROTEIN
FLIM,FLAGELLAR MOTOR
SWITCH PROTEIN FLIN

(Escherichia
virus T4;
Salmonella
enterica;
Salmonella
enterica) 		PF00959
(Phage_lysozyme)
PF01052
(FliMN_C)
PF16973
(FliN_N) 		4 LEU B 179
ASP B 180
GLN B  72
VAL A  92
 None
 1.46A 6bzoF-4yxcB:
undetectable		 6bzoF-4yxcB:
18.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zo0 PROTEIN REP68

(Adeno-associated
dependoparvovirus
A) 		PF08724
(Rep_N) 		4 LEU A  45
ASP A  44
GLN A 162
VAL A  27
 None
 1.19A 6bzoF-4zo0A:
undetectable		 6bzoF-4zo0A:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr0 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 LEU A 150
ASP A 149
GLN A 157
VAL A 282
 None
 1.12A 6bzoF-4zr0A:
2.6		 6bzoF-4zr0A:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zr1 CERAMIDE VERY LONG
CHAIN FATTY ACID
HYDROXYLASE SCS7

(Saccharomyces
cerevisiae) 		PF04116
(FA_hydroxylase) 		4 LEU A 150
ASP A 149
GLN A 157
VAL A 282
 None
 1.24A 6bzoF-4zr1A:
2.7		 6bzoF-4zr1A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5aa6 VANADIUM-DEPENDENT
BROMOPEROXIDASE 2

(Ascophyllum
nodosum) 		no annotation 4 LEU A 167
ASP A  83
GLN A  93
VAL A 430
 None
 1.38A 6bzoF-5aa6A:
0.6		 6bzoF-5aa6A:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5chc DMSO REDUCTASE
FAMILY TYPE II
ENZYME,
MOLYBDOPTERIN
SUBUNIT

(Azospira oryzae) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding) 		4 LEU A 649
ASP A 648
GLN A 655
VAL A 577
 None
 1.15A 6bzoF-5chcA:
undetectable		 6bzoF-5chcA:
20.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h4r BETA-1,3-1,4-GLUCANA
SE

(Caldicellulosiruptor
sp. F32) 		PF00150
(Cellulase) 		4 LEU A 119
ASP A 120
GLN A 123
VAL A 220
 None
 1.11A 6bzoF-5h4rA:
undetectable		 6bzoF-5h4rA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixm LPS-ASSEMBLY PROTEIN
LPTD

(Yersinia pestis) 		PF04453
(OstA_C) 		4 LEU A 324
ASP A 304
GLN A 168
VAL A 211
 None
 1.45A 6bzoF-5ixmA:
undetectable		 6bzoF-5ixmA:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jxr CHROMATIN-REMODELING
COMPLEX ATPASE-LIKE
PROTEIN

(Thermothelomyces
thermophila) 		PF00176
(SNF2_N)
PF00271
(Helicase_C) 		4 LEU A 161
ASP A 158
GLN A 459
VAL A 417
 None
 1.32A 6bzoF-5jxrA:
undetectable		 6bzoF-5jxrA:
23.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ks8 PYRUVATE CARBOXYLASE
SUBUNIT BETA

(Methylobacillus
flagellatus) 		PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA) 		4 LEU C 403
ASP C  95
GLN C  85
VAL C 389
 None
 1.34A 6bzoF-5ks8C:
undetectable		 6bzoF-5ks8C:
21.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ldr BETA-D-GALACTOSIDASE

(Paracoccus sp.
32d) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		4 LEU B 103
ASP B 102
GLN B  70
VAL B  29
 None
PEG  B 803 ( 4.8A)
None
None
 1.34A 6bzoF-5ldrB:
undetectable		 6bzoF-5ldrB:
22.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum) 		no annotation 4 LEU A 629
ASP A1182
GLN A1183
VAL A 812
 None
CA  A1501 (-3.3A)
None
None
 1.48A 6bzoF-5ngyA:
undetectable		 6bzoF-5ngyA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o6v ENVELOPE PROTEIN

(Tick-borne
encephalitis
virus) 		no annotation 4 LEU A 194
ASP A 133
GLN A  50
VAL A  43
 None
 1.45A 6bzoF-5o6vA:
undetectable		 6bzoF-5o6vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogl UNDECAPRENYL-DIPHOSP
HOOLIGOSACCHARIDE--P
ROTEIN
GLYCOTRANSFERASE

(Campylobacter
lari) 		no annotation 4 LEU A 695
ASP A 692
GLN A 501
VAL A 531
 None
 1.46A 6bzoF-5oglA:
undetectable		 6bzoF-5oglA:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tiz SULFOTRANSFERASE

(Schistosoma
japonicum) 		no annotation 4 LEU A  56
ASP A  57
GLN A  60
VAL A 123
 None
 1.24A 6bzoF-5tizA:
undetectable		 6bzoF-5tizA:
19.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ue8 PROTEIN UNC-13
HOMOLOG A

(Rattus
norvegicus) 		PF00130
(C1_1)
PF00168
(C2)
PF06292
(DUF1041)
PF10540
(Membr_traf_MHD) 		4 LEU A1361
ASP A1358
GLN A1362
VAL A1387
 None
 1.29A 6bzoF-5ue8A:
3.9		 6bzoF-5ue8A:
20.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9w DNA MISMATCH REPAIR
PROTEIN MUTS

(Neisseria
gonorrhoeae) 		no annotation 4 LEU A 251
ASP A 252
GLN A 537
VAL A 107
 None
 1.39A 6bzoF-5x9wA:
1.9		 6bzoF-5x9wA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xse KHG/KDPG ALDOLASE

(Zymomonas
mobilis) 		no annotation 4 LEU A  75
ASP A  76
GLN A  79
VAL A 151
 None
 1.23A 6bzoF-5xseA:
undetectable		 6bzoF-5xseA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xse KHG/KDPG ALDOLASE

(Zymomonas
mobilis) 		no annotation 4 LEU A  75
ASP A  76
GLN A 102
VAL A 151
 None
 1.40A 6bzoF-5xseA:
undetectable		 6bzoF-5xseA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a8m -

(-) 		no annotation 4 LEU A 270
ASP A 269
GLN A 263
VAL A 421
 None
 1.45A 6bzoF-6a8mA:
undetectable		 6bzoF-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6a8m -

(-) 		no annotation 4 LEU A 270
ASP A 269
GLN A 263
VAL A 430
 None
 1.38A 6bzoF-6a8mA:
undetectable		 6bzoF-6a8mA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhu MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Bos taurus) 		no annotation 4 LEU A 236
ASP A 240
GLN A 230
VAL A1200
 None
 1.49A 6bzoF-6bhuA:
4.2		 6bzoF-6bhuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bhu MULTIDRUG
RESISTANCE-ASSOCIATE
D PROTEIN 1

(Bos taurus) 		no annotation 4 LEU A 236
ASP A 240
GLN A 230
VAL A1247
 None
 1.40A 6bzoF-6bhuA:
4.2		 6bzoF-6bhuA:
undetectable