SIMILAR PATTERNS OF AMINO ACIDS FOR 6BXN_A_SAMA901_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jhh LEXA REPRESSOR

(Escherichia
coli) 		PF00717
(Peptidase_S24)
PF01726
(LexA_DNA_bind) 		5 VAL A 179
ARG A 148
ILE A 149
ASP A 151
ASP A 150
 None
 1.35A 6bxnA-1jhhA:
undetectable		 6bxnA-1jhhA:
19.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgj PEROXIDASE N

(Arabidopsis
thaliana) 		PF00141
(peroxidase) 		5 LEU A  53
SER A 105
VAL A  22
ILE A  80
ASP A  78
 None
 1.26A 6bxnA-1qgjA:
undetectable		 6bxnA-1qgjA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1reg T4 REGA

(Escherichia
virus T4) 		PF01818
(Translat_reg) 		5 LYS X 117
CYH X  36
ARG X  71
ILE X  74
ASP X  72
 None
 1.24A 6bxnA-1regX:
undetectable		 6bxnA-1regX:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u7n FATTY
ACID/PHOSPHOLIPID
SYNTHESIS PROTEIN
PLSX

(Enterococcus
faecalis) 		PF02504
(FA_synthesis) 		5 LEU A 108
SER A  96
LYS A 295
ILE A  61
ASP A  65
 None
 1.39A 6bxnA-1u7nA:
2.4		 6bxnA-1u7nA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vgp 373AA LONG
HYPOTHETICAL CITRATE
SYNTHASE

(Sulfurisphaera
tokodaii) 		PF00285
(Citrate_synt) 		5 LEU A 267
VAL A 337
ARG A 263
ILE A 178
ASP A 179
 None
 1.24A 6bxnA-1vgpA:
undetectable		 6bxnA-1vgpA:
23.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w6j LANOSTEROL SYNTHASE

(Homo sapiens) 		PF13243
(SQHop_cyclase_C)
PF13249
(SQHop_cyclase_N) 		5 HIS A 232
VAL A 346
ILE A 323
ASP A 326
ASP A 327
 R71  A1733 (-3.5A)
None
None
None
None
 1.45A 6bxnA-1w6jA:
undetectable		 6bxnA-1w6jA:
18.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ysj PROTEIN YXEP

(Bacillus
subtilis) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 PHE A  25
HIS A  96
LYS A  52
VAL A 142
ASP A 326
 None
 1.38A 6bxnA-1ysjA:
1.0		 6bxnA-1ysjA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2btv PROTEIN (VP3 CORE
PROTEIN)

(Bluetongue
virus) 		PF01700
(Orbi_VP3) 		5 VAL A 742
ARG A 763
ILE A 765
ASP A 767
ASP A 768
 None
 1.32A 6bxnA-2btvA:
undetectable		 6bxnA-2btvA:
16.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c5u RNA LIGASE

(Escherichia
virus T4) 		PF09511
(RNA_lig_T4_1) 		5 PHE A  20
ARG A  33
ILE A  34
ASP A  23
ASP A  24
 None
 1.20A 6bxnA-2c5uA:
undetectable		 6bxnA-2c5uA:
22.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e21 TRNA(ILE)-LYSIDINE
SYNTHASE

(Aquifex
aeolicus) 		PF01171
(ATP_bind_3) 		5 LEU A 112
HIS A  63
VAL A 164
ARG A 113
ILE A 129
 None
ANP  A 500 ( 4.5A)
None
ANP  A 500 (-3.0A)
None
 1.25A 6bxnA-2e21A:
3.1		 6bxnA-2e21A:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gjx BETA-HEXOSAMINIDASE
ALPHA CHAIN

(Homo sapiens) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		5 LEU A 473
VAL A 437
ARG A 476
ASP A 430
ASP A 433
 None
 1.42A 6bxnA-2gjxA:
undetectable		 6bxnA-2gjxA:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j7n RNA-DEPENDENT RNA
POLYMERASE

(Neurospora
crassa) 		PF05183
(RdRP) 		5 LEU A 898
SER A 908
CYH A 903
ILE A1175
ASP A1176
 None
 1.19A 6bxnA-2j7nA:
undetectable		 6bxnA-2j7nA:
16.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jki SGT1-LIKE PROTEIN

(Arabidopsis
thaliana) 		PF04969
(CS) 		5 PHE S 205
LEU S 226
GLN S 158
ILE S 232
ASP S 230
 None
 1.37A 6bxnA-2jkiS:
undetectable		 6bxnA-2jkiS:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o26 KIT LIGAND

(Mus musculus) 		PF02404
(SCF) 		5 LEU A  59
VAL A   8
ILE A  82
ASP A  84
ASP A  85
 None
 1.25A 6bxnA-2o26A:
undetectable		 6bxnA-2o26A:
16.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p50 N-ACETYLGLUCOSAMINE-
6-PHOSPHATE
DEACETYLASE

(Escherichia
coli) 		PF01979
(Amidohydro_1) 		5 LEU A 328
VAL A  21
ARG A   8
ILE A   9
ASP A  17
 None
 1.45A 6bxnA-2p50A:
undetectable		 6bxnA-2p50A:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qa2 POLYKETIDE OXYGENASE
CABE

(Streptomyces) 		PF01494
(FAD_binding_3) 		5 GLN A 293
VAL A 325
ARG A 390
ILE A 375
ASP A 374
 None
 1.33A 6bxnA-2qa2A:
2.2		 6bxnA-2qa2A:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5i SALMONELLA
TYPHIMURIUM DB7155
BACTERIOPHAGE DET7
TAILSPIKE

(unidentified
phage) 		PF09251
(PhageP22-tail) 		5 PHE A 353
VAL A 315
ARG A 330
ILE A 309
ASP A 308
 None
 1.21A 6bxnA-2v5iA:
undetectable		 6bxnA-2v5iA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xn1 ALPHA-GALACTOSIDASE

(Lactobacillus
acidophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		5 PHE A 464
LEU A 452
VAL A 519
ARG A 460
ASP A 513
 None
 1.24A 6bxnA-2xn1A:
undetectable		 6bxnA-2xn1A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aeb SUCCINATE
DEHYDROGENASE
[UBIQUINONE]
IRON-SULFUR SUBUNIT,
MITOCHONDRIAL

(Sus scrofa) 		PF13085
(Fer2_3)
PF13534
(Fer4_17) 		5 PHE B  61
HIS B  29
ARG B  18
ILE B  51
ASP B  56
 None
 1.48A 6bxnA-3aebB:
undetectable		 6bxnA-3aebB:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bw8 MONO-ADP-RIBOSYLTRAN
SFERASE C3

(Hathewaya
limosa) 		PF03496
(ADPrib_exo_Tox) 		5 LEU A  86
SER A 186
ARG A  88
ILE A 199
ASP A  90
 None
 1.47A 6bxnA-3bw8A:
undetectable		 6bxnA-3bw8A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bw8 MONO-ADP-RIBOSYLTRAN
SFERASE C3

(Hathewaya
limosa) 		PF03496
(ADPrib_exo_Tox) 		5 LEU A 177
SER A 186
ARG A  88
ILE A 199
ASP A  90
 None
 1.47A 6bxnA-3bw8A:
undetectable		 6bxnA-3bw8A:
24.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs9 PROTEIN GP18

(Listeria
monocytogenes) 		PF06605
(Prophage_tail) 		5 LEU A  82
SER A  59
VAL A  70
ILE A  86
ASP A  85
 None
None
None
None
MLY  A  41 ( 3.9A)
 1.28A 6bxnA-3gs9A:
undetectable		 6bxnA-3gs9A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h14 AMINOTRANSFERASE,
CLASSES I AND II

(Ruegeria
pomeroyi) 		PF00155
(Aminotran_1_2) 		5 PHE A 304
VAL A 316
ARG A 306
ILE A 307
ASP A 319
 None
 1.46A 6bxnA-3h14A:
2.3		 6bxnA-3h14A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hq2 BACILLUS SUBTILIS
M32 CARBOXYPEPTIDASE

(Bacillus
subtilis) 		PF02074
(Peptidase_M32) 		5 LEU A  87
VAL A 461
ILE A 473
ASP A 472
ASP A 476
 None
 1.34A 6bxnA-3hq2A:
undetectable		 6bxnA-3hq2A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iru PHOSHONOACETALDEHYDE
HYDROLASE LIKE
PROTEIN

(Oleispira
antarctica) 		PF13419
(HAD_2) 		5 VAL A 261
ARG A 236
ILE A 252
ASP A 253
ASP A 257
 None
 1.11A 6bxnA-3iruA:
undetectable		 6bxnA-3iruA:
21.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lzd DPH2

(Pyrococcus
horikoshii) 		PF01866
(Diphthamide_syn) 		6 HIS A 184
SER A 236
LYS A 238
VAL A 269
ARG A 289
ASP A 293
 SO4  A 344 (-4.2A)
None
None
None
SO4  A 344 (-4.0A)
None
 1.00A 6bxnA-3lzdA:
34.5		 6bxnA-3lzdA:
38.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lzd DPH2

(Pyrococcus
horikoshii) 		PF01866
(Diphthamide_syn) 		8 LEU A 161
HIS A 184
SER A 236
LYS A 238
GLN A 241
VAL A 269
CYH A 287
ARG A 289
 SO4  A 344 (-3.8A)
SO4  A 344 (-4.2A)
None
None
SF4  A 343 ( 4.4A)
None
SF4  A 343 (-2.3A)
SO4  A 344 (-4.0A)
 0.60A 6bxnA-3lzdA:
34.5		 6bxnA-3lzdA:
38.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mea SAGA-ASSOCIATED
FACTOR 29 HOMOLOG

(Homo sapiens) 		PF07039
(DUF1325) 		5 VAL A 166
CYH A 243
ILE A 176
ASP A 196
ASP A 194
 None
 1.39A 6bxnA-3meaA:
undetectable		 6bxnA-3meaA:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ng3 DEOXYRIBOSE-PHOSPHAT
E ALDOLASE

(Mycobacterium
avium) 		PF01791
(DeoC) 		5 LEU A 136
VAL A 126
ILE A  95
ASP A  96
ASP A 111
 None
 1.43A 6bxnA-3ng3A:
undetectable		 6bxnA-3ng3A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3no6 TRANSCRIPTIONAL
ACTIVATOR TENA

(Staphylococcus
epidermidis) 		PF03070
(TENA_THI-4) 		5 VAL A 143
ARG A 209
ILE A  15
ASP A  17
ASP A  16
 None
 1.38A 6bxnA-3no6A:
undetectable		 6bxnA-3no6A:
21.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pko GERANYLGERANYL
PYROPHOSPHATE
SYNTHASE

(Lactobacillus
brevis) 		PF00348
(polyprenyl_synt) 		5 HIS A  -3
SER A 237
VAL A 239
ASP A 215
ASP A 216
 None
 1.43A 6bxnA-3pkoA:
undetectable		 6bxnA-3pkoA:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rva ORGANOPHOSPHORUS
ACID ANHYDROLASE

(Alteromonas
macleodii) 		PF00557
(Peptidase_M24) 		5 HIS A 335
VAL A 176
ARG A 421
ILE A 256
ASP A 244
 None
None
None
None
MN  A 452 (-2.1A)
 1.24A 6bxnA-3rvaA:
undetectable		 6bxnA-3rvaA:
20.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sun DNA POLYMERASE

(Escherichia
virus RB69) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 LEU A  83
VAL A 471
ARG A 576
ILE A 369
ASP A 366
 None
 1.43A 6bxnA-3sunA:
undetectable		 6bxnA-3sunA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t1i DOUBLE-STRAND BREAK
REPAIR PROTEIN
MRE11A

(Homo sapiens) 		PF00149
(Metallophos)
PF04152
(Mre11_DNA_bind) 		5 LEU A 201
VAL A 241
ARG A 202
ILE A 238
ASP A 239
 None
 1.37A 6bxnA-3t1iA:
undetectable		 6bxnA-3t1iA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tcm ALANINE
AMINOTRANSFERASE 2

(Hordeum vulgare) 		PF00155
(Aminotran_1_2) 		5 PHE A 442
LEU A 193
SER A 178
GLN A 173
ASP A 421
 None
 1.41A 6bxnA-3tcmA:
2.0		 6bxnA-3tcmA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v9e LACCASE

(Botrytis aclada) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 LEU A 486
HIS A 488
GLN A 107
VAL A  75
ILE A  86
 None
CU  A 602 (-3.1A)
None
None
None
 1.47A 6bxnA-3v9eA:
undetectable		 6bxnA-3v9eA:
18.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w53 BETA-GLUCOSIDASE

(Micrococcus
antarcticus) 		PF00232
(Glyco_hydro_1) 		5 LEU A 255
VAL A 330
ARG A 252
ASP A 266
ASP A 270
 None
 1.39A 6bxnA-3w53A:
undetectable		 6bxnA-3w53A:
21.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE

(Escherichia
coli) 		no annotation 5 LEU B  55
SER B  47
LYS B  49
ILE B 170
ASP B 166
 None
None
None
None
PLG  B 401 (-2.7A)
 1.36A 6bxnA-3wlxB:
3.3		 6bxnA-3wlxB:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4af0 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Cryptococcus
neoformans) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 LEU B 287
VAL B 364
ARG B 336
ILE B 337
ASP B 378
 None
None
MOA  B1526 (-3.6A)
None
IMP  B1527 (-2.5A)
 1.41A 6bxnA-4af0B:
undetectable		 6bxnA-4af0B:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bf7 ARABINOGALACTAN
ENDO-1,4-BETA-GALACT
OSIDASE A

(Aspergillus
nidulans) 		PF07745
(Glyco_hydro_53) 		5 LEU A 177
HIS A 179
ARG A  45
ILE A  44
ASP A   8
 None
None
GOL  A1343 ( 4.2A)
None
None
 1.43A 6bxnA-4bf7A:
undetectable		 6bxnA-4bf7A:
22.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bou OTU
DOMAIN-CONTAINING
PROTEIN 3

(Homo sapiens) 		PF02338
(OTU) 		5 LEU A 155
VAL A 150
ARG A 178
ILE A 175
ASP A 184
 None
 1.38A 6bxnA-4bouA:
undetectable		 6bxnA-4bouA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fqd NIKO PROTEIN

(Streptomyces
tendae) 		PF00275
(EPSP_synthase) 		5 PHE A 340
HIS A 106
VAL A 269
ILE A 266
ASP A 264
 None
SO4  A 501 (-4.1A)
None
None
None
 1.49A 6bxnA-4fqdA:
undetectable		 6bxnA-4fqdA:
20.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxq ARGINASE-1

(Homo sapiens) 		PF00491
(Arginase) 		5 LEU A  31
SER A 107
VAL A  84
ILE A  11
ASP A  49
 None
 1.26A 6bxnA-4hxqA:
2.3		 6bxnA-4hxqA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oer NIKA PROTEIN

(Brucella suis) 		PF00496
(SBP_bac_5) 		5 GLN A 420
VAL A 406
ARG A 455
ILE A 452
ASP A 451
 None
 1.40A 6bxnA-4oerA:
undetectable		 6bxnA-4oerA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4paf TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT, PUTATIVE

(Ruegeria
pomeroyi) 		PF03480
(DctP) 		5 PHE A 235
LEU A 110
SER A  96
ILE A 177
ASP A 209
 DHB  A 401 (-4.5A)
None
None
None
None
 1.49A 6bxnA-4pafA:
undetectable		 6bxnA-4pafA:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtq XAC2610 PROTEIN

(Xanthomonas
citri) 		no annotation 5 SER A 192
VAL A 177
ILE A 152
ASP A 151
ASP A 159
 None
None
None
CA  A 301 (-3.2A)
CA  A 301 (-2.3A)
 1.49A 6bxnA-4qtqA:
undetectable		 6bxnA-4qtqA:
22.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v0k ARF-LIKE SMALL
GTPASE

(Chlamydomonas
reinhardtii) 		PF00025
(Arf) 		5 PHE A 126
LEU A 163
VAL A  22
ARG A  36
ILE A  34
 None
GDP  A 700 (-4.4A)
None
None
None
 1.35A 6bxnA-4v0kA:
2.0		 6bxnA-4v0kA:
18.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v1y ATRAZINE
CHLOROHYDROLASE

(Pseudomonas sp.
ADP) 		PF01979
(Amidohydro_1) 		5 LEU A 408
HIS A 405
VAL A 424
ASP A 396
ASP A 422
 None
 1.43A 6bxnA-4v1yA:
undetectable		 6bxnA-4v1yA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w2r ENHANCER OF ZESTE 2
POLYCOMB REPRESSIVE
COMPLEX 2 SUBUNIT

(Anolis
carolinensis) 		no annotation 5 PHE A 570
VAL A 122
ILE A 543
ASP A 546
ASP A 124
 None
 1.35A 6bxnA-4w2rA:
undetectable		 6bxnA-4w2rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjs RSA4

(Chaetomium
thermophilum) 		PF00400
(WD40) 		5 SER A 421
LYS A 429
VAL A 407
ARG A 399
ASP A 381
 None
 1.08A 6bxnA-4wjsA:
undetectable		 6bxnA-4wjsA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wwx V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1

(Mus musculus) 		PF12940
(RAG1) 		5 LEU B 657
SER B 561
VAL B 532
ILE B 535
ASP B 536
 None
 1.32A 6bxnA-4wwxB:
undetectable		 6bxnA-4wwxB:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xrw BEXL

(Amycolatopsis
orientalis) 		PF10604
(Polyketide_cyc2) 		5 LEU A 107
HIS A   6
SER A  82
ILE A 124
ASP A 125
 None
 1.36A 6bxnA-4xrwA:
undetectable		 6bxnA-4xrwA:
22.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xwu INOSINE-5'-MONOPHOSP
HATE
DEHYDROGENASE,INOSIN
E-5'-MONOPHOSPHATE
DEHYDROGENASE

(Eremothecium
gossypii) 		PF00478
(IMPDH) 		5 LEU A 276
VAL A 353
ARG A 325
ILE A 326
ASP A 367
 None
 1.40A 6bxnA-4xwuA:
undetectable		 6bxnA-4xwuA:
22.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ajk HOMOLOG OF VACCINIA
VIRUS CDS F1L

(Variola virus) 		PF11099
(M11L) 		5 LEU A 158
ARG A 157
ILE A 194
ASP A 190
ASP A 191
 None
 1.42A 6bxnA-5ajkA:
undetectable		 6bxnA-5ajkA:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c9e SEPL

(Escherichia
coli) 		PF07201
(HrpJ) 		5 LEU A 202
SER A 297
VAL A 301
ASP A 274
ASP A 272
 None
 1.45A 6bxnA-5c9eA:
undetectable		 6bxnA-5c9eA:
20.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cqf L-LYSINE
6-MONOOXYGENASE

(Pseudomonas
syringae group
genomosp. 3) 		PF13434
(K_oxygenase) 		5 SER A 164
VAL A 162
ARG A 418
ILE A 419
ASP A 378
 None
None
IOD  A 503 ( 4.9A)
None
None
 1.46A 6bxnA-5cqfA:
2.9		 6bxnA-5cqfA:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmh UNCHARACTERIZED
PROTEIN CONSERVED IN
BACTERIA

(Cupriavidus
necator) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		5 PHE A  98
SER A 173
GLN A 172
ARG A  64
ASP A  17
 None
 1.46A 6bxnA-5dmhA:
4.4		 6bxnA-5dmhA:
21.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5esx PURINE/PYRIMIDINE
PHOSPHORIBOSYLTRANSF
ERASE

(Legionella
pneumophila) 		PF00156
(Pribosyltran) 		5 LEU A  60
HIS A  61
ARG A  62
ILE A  32
ASP A  28
 None
 1.28A 6bxnA-5esxA:
3.2		 6bxnA-5esxA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gm3 ENDOGLUCANASE-1

(Aspergillus
aculeatus) 		PF01670
(Glyco_hydro_12) 		5 LYS A  73
VAL A 220
ILE A  81
ASP A 176
ASP A 173
 None
 1.48A 6bxnA-5gm3A:
undetectable		 6bxnA-5gm3A:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i7n MAOC-LIKE
DEHYDRATASE

(Mycobacteroides
abscessus) 		PF01575
(MaoC_dehydratas)
PF13452
(MaoC_dehydrat_N) 		5 PHE A 341
SER A 310
VAL A 212
ARG A 316
ASP A 208
 None
 1.45A 6bxnA-5i7nA:
undetectable		 6bxnA-5i7nA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ikp GLYCOGEN
PHOSPHORYLASE, BRAIN
FORM

(Homo sapiens) 		PF00343
(Phosphorylase) 		5 LEU A 243
VAL A 333
ARG A 242
ILE A 307
ASP A 306
 None
None
AMP  A 902 ( 4.2A)
None
None
 1.49A 6bxnA-5ikpA:
undetectable		 6bxnA-5ikpA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ji5 BUPHA.10154.A.B1

(Paraburkholderia
phymatum) 		PF00850
(Hist_deacetyl) 		5 HIS A 126
SER A 212
VAL A 217
ILE A 185
ASP A 161
 EDO  A 403 (-4.2A)
None
None
None
NA  A 406 (-3.4A)
 1.45A 6bxnA-5ji5A:
undetectable		 6bxnA-5ji5A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jne E3 SUMO-PROTEIN
LIGASE
SIZ1,UBIQUITIN-LIKE
PROTEIN SMT3

(Saccharomyces
cerevisiae) 		PF02891
(zf-MIZ)
PF11976
(Rad60-SLD)
PF14324
(PINIT) 		5 LEU A 319
GLN A 392
ILE A 363
ASP A 384
ASP A 361
 None
 1.33A 6bxnA-5jneA:
undetectable		 6bxnA-5jneA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ksd ATPASE 2, PLASMA
MEMBRANE-TYPE

(Arabidopsis
thaliana) 		PF00122
(E1-E2_ATPase)
PF00690
(Cation_ATPase_N)
PF00702
(Hydrolase) 		5 SER A 691
LYS A 692
VAL A 292
ILE A 687
ASP A 684
 None
 1.42A 6bxnA-5ksdA:
2.0		 6bxnA-5ksdA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ktz VP1

(Enterovirus C) 		PF00073
(Rhv) 		5 HIS 1 248
SER 1 182
GLN 1 156
ASP 1 171
ASP 1 172
 None
 1.34A 6bxnA-5ktz1:
undetectable		 6bxnA-5ktz1:
18.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ls6 HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2,HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2,HISTONE-LYSINE
N-METHYLTRANSFERASE
EZH2

(Homo sapiens) 		PF00856
(SET)
PF11616
(EZH2_WD-Binding) 		5 PHE A 673
VAL A 122
ILE A 646
ASP A 649
ASP A 124
 None
 1.31A 6bxnA-5ls6A:
undetectable		 6bxnA-5ls6A:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lxz SECRETED PROTEIN

(Streptomyces
lividans) 		PF07646
(Kelch_2)
PF09118
(DUF1929) 		5 LEU B 600
SER B 585
ARG B 580
ILE B 453
ASP B 457
 None
None
EDO  B 710 (-2.7A)
None
None
 1.49A 6bxnA-5lxzB:
undetectable		 6bxnA-5lxzB:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mc5 XAA-PRO DIPEPTIDASE

(Homo sapiens) 		no annotation 5 HIS A 366
VAL A 467
ARG A 450
ILE A 288
ASP A 276
 PRO  A 504 (-3.8A)
None
PRO  A 504 (-3.7A)
None
MN  A 500 (-1.9A)
 1.45A 6bxnA-5mc5A:
undetectable		 6bxnA-5mc5A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mu5 UNCHARACTERIZED
PROTEIN

(Magnetospirillum
magneticum) 		no annotation 5 LEU A 509
VAL A 309
ILE A 284
ASP A 286
ASP A 285
 None
None
None
PG4  A 705 ( 4.7A)
None
 1.44A 6bxnA-5mu5A:
undetectable		 6bxnA-5mu5A:
21.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 5 PHE B 824
LEU B 120
VAL B 857
CYH B 827
ILE B 101
 None
 1.25A 6bxnA-5nd1B:
undetectable		 6bxnA-5nd1B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tc3 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE

(Eremothecium
gossypii) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 LEU A 276
VAL A 353
ARG A 325
ILE A 326
ASP A 367
 None
None
5GP  A 600 (-3.1A)
None
5GP  A 600 (-2.4A)
 1.39A 6bxnA-5tc3A:
undetectable		 6bxnA-5tc3A:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u3f BRANCHED-CHAIN-AMINO
-ACID
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF01063
(Aminotran_4) 		5 GLN A 125
VAL A 118
ARG A  54
ILE A  42
ASP A  43
 None
 1.46A 6bxnA-5u3fA:
undetectable		 6bxnA-5u3fA:
25.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8f ORIGIN RECOGNITION
COMPLEX SUBUNIT 3

(Saccharomyces
cerevisiae) 		no annotation 5 LEU C 285
HIS C 405
SER C 304
ILE C 433
ASP C 437
 None
 1.26A 6bxnA-5v8fC:
undetectable		 6bxnA-5v8fC:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vvr DNA REPAIR AND
RECOMBINATION
PROTEIN RAD26

(Saccharomyces
cerevisiae) 		no annotation 5 LEU M 623
GLN M 593
CYH M 627
ARG M 624
ASP M 749
 None
 1.43A 6bxnA-5vvrM:
2.9		 6bxnA-5vvrM:
15.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z6o PROTEASE

(Penicillium
cyclopium) 		no annotation 5 SER A 160
VAL A 234
ARG A 255
ILE A 256
ASP A 259
 None
 1.30A 6bxnA-5z6oA:
2.4		 6bxnA-5z6oA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bxn DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2

(Candidatus
Methanoperedens
nitroreducens) 		no annotation 5 HIS A 180
VAL A 298
ARG A 285
ASP A 289
ASP A 290
 SAM  A 901 (-4.2A)
None
SAM  A 901 (-4.1A)
SAM  A 901 (-3.9A)
SAM  A 901 (-3.2A)
 1.45A 6bxnA-6bxnA:
47.0		 6bxnA-6bxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bxn DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2

(Candidatus
Methanoperedens
nitroreducens) 		no annotation 12 PHE A  58
LEU A 157
HIS A 180
SER A 232
LYS A 234
GLN A 237
VAL A 265
CYH A 283
ARG A 285
ILE A 286
ASP A 289
ASP A 290
 SAM  A 901 ( 3.5A)
SAM  A 901 (-3.8A)
SAM  A 901 (-4.2A)
SAM  A 901 ( 3.9A)
SAM  A 901 (-4.9A)
SAM  A 901 (-3.0A)
SAM  A 901 (-4.0A)
SF4  A 900 ( 2.2A)
SAM  A 901 (-4.1A)
SAM  A 901 (-4.7A)
SAM  A 901 (-3.9A)
SAM  A 901 (-3.2A)
 0.00A 6bxnA-6bxnA:
47.0		 6bxnA-6bxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cg0 V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1

(Mus musculus) 		no annotation 5 LEU A 657
SER A 561
VAL A 532
ILE A 535
ASP A 536
 None
 1.03A 6bxnA-6cg0A:
undetectable		 6bxnA-6cg0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoq DIPEPTIDYL PEPTIDASE
9

(Homo sapiens) 		no annotation 5 LEU A 541
SER A 502
GLN A 516
ARG A 540
ASP A 520
 None
 1.43A 6bxnA-6eoqA:
undetectable		 6bxnA-6eoqA:
undetectable