SIMILAR PATTERNS OF AMINO ACIDS FOR 6BXM_A_SAMA402

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a04 NITRATE/NITRITE
RESPONSE REGULATOR
PROTEIN NARL

(Escherichia
coli) 		PF00072
(Response_reg)
PF00196
(GerE) 		5 LEU A  68
GLY A  67
LEU A  55
ILE A  12
ASP A  59
 None
 1.10A 6bxmA-1a04A:
4.9		 6bxmA-1a04A:
21.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dhr DIHYDROPTERIDINE
REDUCTASE

(Rattus
norvegicus) 		PF00106
(adh_short) 		5 GLY A  19
LEU A  70
VAL A  67
ILE A  36
ASP A  37
 None
None
None
None
NAD  A 241 (-2.8A)
 1.08A 6bxmA-1dhrA:
2.6		 6bxmA-1dhrA:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e8c UDP-N-ACETYLMURAMOYL
ALANYL-D-GLUTAMATE--
2,6-DIAMINOPIMELATE
LIGASE

(Escherichia
coli) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 PHE A 383
GLY A 387
VAL A 439
ILE A 424
ASP A 426
 None
 1.19A 6bxmA-1e8cA:
2.3		 6bxmA-1e8cA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2d ATP SULFURYLASE

(Penicillium
chrysogenum) 		PF01583
(APS_kinase)
PF01747
(ATP-sulfurylase)
PF14306
(PUA_2) 		5 PHE A 497
GLY A 396
LEU A 499
VAL A 500
ILE A 399
 None
 1.05A 6bxmA-1i2dA:
2.6		 6bxmA-1i2dA:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1izo CYTOCHROME P450
152A1

(Bacillus
subtilis) 		PF00067
(p450) 		5 SER A 406
GLN A 391
LEU A 134
VAL A 133
ASP A 130
 None
 1.06A 6bxmA-1izoA:
undetectable		 6bxmA-1izoA:
21.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l8t AMINOGLYCOSIDE
3'-PHOSPHOTRANSFERAS
E

(Enterococcus
faecalis) 		PF01636
(APH) 		5 GLY A 192
LEU A 240
VAL A 238
ILE A 228
ASP A 231
 None
None
None
None
KAN  A   1 ( 4.9A)
 1.06A 6bxmA-1l8tA:
undetectable		 6bxmA-1l8tA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lnz SPO0B-ASSOCIATED
GTP-BINDING PROTEIN

(Bacillus
subtilis) 		PF01018
(GTP1_OBG)
PF01926
(MMR_HSR1) 		5 LEU A 300
GLN A 277
LEU A 163
ILE A 261
ASP A 257
 None
 1.15A 6bxmA-1lnzA:
2.1		 6bxmA-1lnzA:
23.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m5h FORMYLMETHANOFURAN--
TETRAHYDROMETHANOPTE
RIN
FORMYLTRANSFERASE

(Archaeoglobus
fulgidus) 		PF01913
(FTR)
PF02741
(FTR_C) 		5 LEU A 286
GLY A 287
SER A  46
ILE A  18
ASP A  17
 None
 1.10A 6bxmA-1m5hA:
undetectable		 6bxmA-1m5hA:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oh9 ACETYLGLUTAMATE
KINASE

(Escherichia
coli) 		PF00696
(AA_kinase) 		5 LEU A   9
VAL A  41
ARG A  36
ILE A   6
ASP A 175
 None
 1.18A 6bxmA-1oh9A:
undetectable		 6bxmA-1oh9A:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p31 UDP-N-ACETYLMURAMATE
--ALANINE LIGASE

(Haemophilus
influenzae) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 LEU A 419
LEU A 444
VAL A 443
ILE A 432
ASP A 430
 None
 1.07A 6bxmA-1p31A:
4.4		 6bxmA-1p31A:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgj PEROXIDASE N

(Arabidopsis
thaliana) 		PF00141
(peroxidase) 		5 LEU A  53
SER A 105
VAL A  22
ILE A  80
ASP A  78
 None
 1.16A 6bxmA-1qgjA:
undetectable		 6bxmA-1qgjA:
20.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1reg T4 REGA

(Escherichia
virus T4) 		PF01818
(Translat_reg) 		5 LYS X 117
CYH X  36
ARG X  71
ILE X  74
ASP X  72
 None
 1.16A 6bxmA-1regX:
undetectable		 6bxmA-1regX:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1snz ALDOSE 1-EPIMERASE

(Homo sapiens) 		PF01263
(Aldose_epim) 		5 PHE A 304
LEU A 234
GLY A 231
LEU A 269
ASP A 191
 None
 1.17A 6bxmA-1snzA:
undetectable		 6bxmA-1snzA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tc5 PROBABLE EUKARYOTIC
D-AMINO ACID TRNA
DEACYLASE,
LMAJ005534AAA

(Leishmania
major) 		PF02580
(Tyr_Deacylase) 		5 GLY A 103
LEU A  65
ARG A  12
ILE A  11
ASP A 193
 None
 1.11A 6bxmA-1tc5A:
undetectable		 6bxmA-1tc5A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v6a L-LACTATE
DEHYDROGENASE A
CHAIN

(Cyprinus carpio) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLY A 160
LEU A 109
VAL A 110
ILE A 142
ASP A 141
 None
 1.21A 6bxmA-1v6aA:
3.7		 6bxmA-1v6aA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2a3l AMP DEAMINASE

(Arabidopsis
thaliana) 		PF00962
(A_deaminase) 		5 PHE A 479
LEU A 429
VAL A 432
ARG A 476
ASP A 449
 None
 1.01A 6bxmA-2a3lA:
undetectable		 6bxmA-2a3lA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2au1 IGG-DEGRADING
PROTEASE

(Streptococcus
pyogenes) 		PF09028
(Mac-1) 		5 LEU A 323
GLY A 324
SER A 285
LEU A  93
ASP A 174
 None
 1.00A 6bxmA-2au1A:
undetectable		 6bxmA-2au1A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bf6 EXO-ALPHA-SIALIDASE

(Clostridium
perfringens) 		PF13088
(BNR_2) 		5 GLY A 569
LEU A 343
ARG A 479
ILE A 480
ASP A 501
 None
 1.22A 6bxmA-2bf6A:
undetectable		 6bxmA-2bf6A:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c11 MEMBRANE COPPER
AMINE OXIDASE

(Homo sapiens) 		PF01179
(Cu_amine_oxid)
PF02727
(Cu_amine_oxidN2)
PF02728
(Cu_amine_oxidN3) 		5 LEU A 608
GLY A 702
LEU A 359
VAL A 360
ILE A 363
 None
 0.93A 6bxmA-2c11A:
undetectable		 6bxmA-2c11A:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5w PEPTIDE ABC
TRANSPORTER,
PEPTIDE-BINDING
PROTEIN

(Thermus
thermophilus) 		PF00496
(SBP_bac_5) 		5 GLY A 291
SER A 282
LEU A 275
ILE A 295
ASP A 294
 None
 1.08A 6bxmA-2d5wA:
2.6		 6bxmA-2d5wA:
18.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dg2 APOLIPOPROTEIN A-I
BINDING PROTEIN

(Mus musculus) 		PF03853
(YjeF_N) 		5 LEU A  56
GLY A 230
VAL A 154
CYH A  61
ASP A 188
 None
 1.04A 6bxmA-2dg2A:
3.4		 6bxmA-2dg2A:
20.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3d UTP--GLUCOSE-1-PHOSP
HATE
URIDYLYLTRANSFERASE

(Escherichia
coli) 		PF00483
(NTP_transferase) 		5 LEU A 120
GLY A 116
SER A 165
ILE A 245
ASP A 243
 None
 1.24A 6bxmA-2e3dA:
undetectable		 6bxmA-2e3dA:
21.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fj0 CARBOXYLIC ESTER
HYDROLASE

(Manduca sexta) 		PF00135
(COesterase) 		5 LEU A 137
GLY A 136
LEU A 203
ARG A 216
ASP A 218
 None
 1.06A 6bxmA-2fj0A:
undetectable		 6bxmA-2fj0A:
21.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i80 D-ALANINE-D-ALANINE
LIGASE

(Staphylococcus
aureus) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		5 GLY A  70
LEU A 108
ARG A  50
ILE A  43
ASP A  48
 None
 1.21A 6bxmA-2i80A:
3.3		 6bxmA-2i80A:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iht CARBOXYETHYLARGININE
SYNTHASE

(Streptomyces
clavuligerus) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 LEU A 495
GLY A 494
LEU A 459
VAL A 486
ASP A 463
 TPP  A 600 ( 4.3A)
TPP  A 600 (-3.2A)
None
None
MG  A 601 ( 2.8A)
 1.20A 6bxmA-2ihtA:
3.1		 6bxmA-2ihtA:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6i FORMATE
DEHYDROGENASE

([Candida]
boidinii) 		PF00389
(2-Hacid_dh)
PF02826
(2-Hacid_dh_C) 		5 GLY A 250
LEU A 132
VAL A 133
ARG A 277
ASP A 158
 None
 1.19A 6bxmA-2j6iA:
3.2		 6bxmA-2j6iA:
21.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o2z HYPOTHETICAL PROTEIN

(Bacillus
halodurans) 		PF01933
(UPF0052) 		5 LEU A  93
GLY A  91
SER A 129
VAL A  35
ARG A  58
 None
None
None
None
SO4  A 323 (-3.8A)
 1.26A 6bxmA-2o2zA:
undetectable		 6bxmA-2o2zA:
22.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qm3 PREDICTED
METHYLTRANSFERASE

(Pyrococcus
furiosus) 		PF01861
(DUF43) 		5 LEU A 155
GLY A 156
LEU A 140
VAL A 138
ASP A 159
 None
None
None
None
CA  A 350 ( 4.5A)
 1.26A 6bxmA-2qm3A:
3.2		 6bxmA-2qm3A:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qq4 IRON-SULFUR CLUSTER
BIOSYNTHESIS PROTEIN
ISCU

(Thermus
thermophilus) 		PF01592
(NifU_N) 		5 GLY A  40
LEU A 119
VAL A 116
CYH A 125
ILE A  66
 None
None
None
ZN  A 139 (-2.3A)
None
 1.21A 6bxmA-2qq4A:
undetectable		 6bxmA-2qq4A:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v5i SALMONELLA
TYPHIMURIUM DB7155
BACTERIOPHAGE DET7
TAILSPIKE

(unidentified
phage) 		PF09251
(PhageP22-tail) 		5 PHE A 353
VAL A 315
ARG A 330
ILE A 309
ASP A 308
 None
 1.17A 6bxmA-2v5iA:
undetectable		 6bxmA-2v5iA:
18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2we8 XANTHINE
DEHYDROGENASE

(Mycolicibacterium
smegmatis) 		PF02625
(XdhC_CoxI)
PF13478
(XdhC_C) 		5 LEU A 327
LEU A 208
VAL A 274
ARG A 329
ASP A 297
 None
 0.93A 6bxmA-2we8A:
3.3		 6bxmA-2we8A:
23.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1

(Gracilariopsis
lemaneiformis) 		PF01055
(Glyco_hydro_31) 		6 LEU A 409
GLY A 371
VAL A 719
ARG A 729
ILE A 695
ASP A 694
 None
 1.47A 6bxmA-2x2iA:
undetectable		 6bxmA-2x2iA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3asa LL-DIAMINOPIMELATE
AMINOTRANSFERASE

(Chlamydia
trachomatis) 		PF00155
(Aminotran_1_2) 		5 PHE A 370
LEU A 373
GLY A  41
LEU A 386
ILE A  36
 None
 1.12A 6bxmA-3asaA:
2.5		 6bxmA-3asaA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3axy 14-3-3-LIKE PROTEIN
GF14-C

(Oryza sativa) 		PF00244
(14-3-3) 		5 GLY C 173
SER C 113
LEU C 109
VAL C 110
ASP C 128
 None
 1.22A 6bxmA-3axyC:
undetectable		 6bxmA-3axyC:
21.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3clh 3-DEHYDROQUINATE
SYNTHASE

(Helicobacter
pylori) 		PF01761
(DHQ_synthase) 		5 LEU A 247
GLY A 249
LEU A 199
ILE A 175
ASP A 126
 None
None
None
None
NAD  A 400 (-3.6A)
 1.23A 6bxmA-3clhA:
4.3		 6bxmA-3clhA:
24.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dy5 ALLENE OXIDE
SYNTHASE-LIPOXYGENAS
E PROTEIN

(Plexaura
homomalla) 		PF00305
(Lipoxygenase)
PF01477
(PLAT) 		5 LEU A 817
GLY A 818
ARG A 692
ILE A 691
ASP A 690
 None
 1.24A 6bxmA-3dy5A:
undetectable		 6bxmA-3dy5A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e74 ALLANTOINASE

(Escherichia
coli) 		PF01979
(Amidohydro_1) 		5 PHE A 109
LEU A  96
LEU A 449
VAL A 142
ASP A 101
 None
 1.25A 6bxmA-3e74A:
undetectable		 6bxmA-3e74A:
23.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fxg RHAMNONATE
DEHYDRATASE

(Fusarium
graminearum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 LEU A 110
LEU A  91
VAL A  92
ILE A 135
ASP A 136
 None
 1.07A 6bxmA-3fxgA:
undetectable		 6bxmA-3fxgA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gs9 PROTEIN GP18

(Listeria
monocytogenes) 		PF06605
(Prophage_tail) 		5 LEU A  82
SER A  59
VAL A  70
ILE A  86
ASP A  85
 None
None
None
None
MLY  A  41 ( 3.9A)
 1.23A 6bxmA-3gs9A:
undetectable		 6bxmA-3gs9A:
23.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhs PHENOLOXIDASE
SUBUNIT 1

(Manduca sexta) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		5 PHE B 151
LEU B 459
GLY B 460
GLN B 279
ASP B  13
 None
 1.14A 6bxmA-3hhsB:
undetectable		 6bxmA-3hhsB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iv3 TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2

(Streptococcus
mutans) 		PF01791
(DeoC) 		5 GLY A  30
SER A 284
LEU A  55
VAL A  56
ASP A  70
 None
 1.15A 6bxmA-3iv3A:
undetectable		 6bxmA-3iv3A:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jrk TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 2

(Streptococcus
pyogenes) 		PF01791
(DeoC) 		5 GLY A  26
SER A 280
LEU A  51
VAL A  52
ASP A  66
 GOL  A 323 ( 4.3A)
None
None
None
None
 1.10A 6bxmA-3jrkA:
undetectable		 6bxmA-3jrkA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k40 AROMATIC-L-AMINO-ACI
D DECARBOXYLASE

(Drosophila
melanogaster) 		PF00282
(Pyridoxal_deC) 		5 LEU A 350
GLY A 351
GLN A 145
LEU A 153
ARG A 352
 None
 1.09A 6bxmA-3k40A:
2.5		 6bxmA-3k40A:
22.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lp9 LS-24

(Lathyrus
sativus) 		PF00045
(Hemopexin) 		5 GLY A 100
LEU A 134
CYH A  83
ILE A 104
ASP A 106
 None
 0.85A 6bxmA-3lp9A:
undetectable		 6bxmA-3lp9A:
20.30
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lzd DPH2

(Pyrococcus
horikoshii) 		PF01866
(Diphthamide_syn) 		8 LEU A 161
GLY A 162
SER A 236
LYS A 238
GLN A 241
VAL A 269
CYH A 287
ARG A 289
 SO4  A 344 (-3.8A)
SO4  A 344 (-3.5A)
None
None
SF4  A 343 ( 4.4A)
None
SF4  A 343 (-2.3A)
SO4  A 344 (-4.0A)
 0.56A 6bxmA-3lzdA:
20.1		 6bxmA-3lzdA:
38.44
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lzd DPH2

(Pyrococcus
horikoshii) 		PF01866
(Diphthamide_syn) 		7 LEU A 161
GLY A 162
SER A 236
LYS A 238
VAL A 269
ARG A 289
ASP A 293
 SO4  A 344 (-3.8A)
SO4  A 344 (-3.5A)
None
None
None
SO4  A 344 (-4.0A)
None
 0.87A 6bxmA-3lzdA:
20.1		 6bxmA-3lzdA:
38.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3) 		5 LEU A 521
GLY A 522
LEU A 436
ILE A 409
ASP A 410
 None
 1.14A 6bxmA-3mcaA:
2.7		 6bxmA-3mcaA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mv3 COATOMER SUBUNIT
ALPHA

(Saccharomyces
cerevisiae) 		PF06957
(COPI_C) 		5 LEU A 987
GLY A 986
LEU A 914
VAL A 915
ILE A 946
 None
 1.11A 6bxmA-3mv3A:
undetectable		 6bxmA-3mv3A:
23.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3myo TAGATOSE
1,6-DIPHOSPHATE
ALDOLASE 1

(Streptococcus
pyogenes) 		PF01791
(DeoC) 		5 GLY A  29
SER A 283
LEU A  54
VAL A  55
ASP A  69
 None
 1.16A 6bxmA-3myoA:
undetectable		 6bxmA-3myoA:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxx CARVEOL
DEHYDROGENASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		5 GLY A  66
VAL A  11
ARG A  67
ILE A  33
ASP A  32
 None
 1.22A 6bxmA-3pxxA:
2.5		 6bxmA-3pxxA:
23.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t7c CARVEOL
DEHYDROGENASE

(Mycobacterium
avium) 		PF13561
(adh_short_C2) 		5 GLY A  67
LEU A 101
ARG A  68
ILE A  34
ASP A  33
 None
 1.06A 6bxmA-3t7cA:
undetectable		 6bxmA-3t7cA:
22.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tdf DIHYDRODIPICOLINATE
SYNTHASE

(Acinetobacter
baumannii) 		PF00701
(DHDPS) 		5 LEU A 101
GLY A  76
LEU A  27
VAL A  28
ILE A  63
 None
 1.26A 6bxmA-3tdfA:
undetectable		 6bxmA-3tdfA:
24.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqh QUINONE
OXIDOREDUCTASE

(Coxiella
burnetii) 		PF08240
(ADH_N)
PF13602
(ADH_zinc_N_2) 		5 GLY A 160
GLN A 168
LEU A 278
VAL A 279
ILE A 286
 NDP  A 500 (-3.6A)
None
None
None
None
 1.20A 6bxmA-3tqhA:
4.9		 6bxmA-3tqhA:
23.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ttg PUTATIVE
AMINOMETHYLTRANSFERA
SE

(Leptospirillum
rubarum) 		PF01571
(GCV_T)
PF08669
(GCV_T_C) 		5 PHE A 176
LEU A 144
GLY A 147
SER A  23
ASP A 174
 None
 1.26A 6bxmA-3ttgA:
undetectable		 6bxmA-3ttgA:
21.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ue3 SEPTUM FORMATION,
PENICILLIN BINDING
PROTEIN 3,
PEPTIDOGLYCAN
SYNTHETASE

(Acinetobacter
sp. ATCC 27244) 		PF00905
(Transpeptidase)
PF03717
(PBP_dimer) 		5 LEU A 547
GLY A 527
LEU A 499
VAL A 498
ILE A 387
 None
 1.18A 6bxmA-3ue3A:
undetectable		 6bxmA-3ue3A:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uet ALPHA-1,3/4-FUCOSIDA
SE

(Bifidobacterium
longum) 		PF01120
(Alpha_L_fucos) 		5 LEU A 311
GLY A 315
LEU A 395
ARG A 444
ILE A 408
 None
 1.24A 6bxmA-3uetA:
undetectable		 6bxmA-3uetA:
20.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ux8 EXCINUCLEASE ABC, A
SUBUNIT

(Geobacillus sp.
Y412MC52) 		PF00005
(ABC_tran) 		5 GLY A 813
VAL A 890
ARG A 866
ILE A 864
ASP A 862
 None
 0.97A 6bxmA-3ux8A:
undetectable		 6bxmA-3ux8A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bas ADP-RIBOSYLATION
FACTOR, PUTATIVE
(SMALL GTPASE,
PUTATIVE)

(Trypanosoma
brucei) 		PF00025
(Arf) 		5 LEU A 173
GLY A 169
LEU A 142
VAL A 139
ILE A 155
 None
 1.22A 6bxmA-4basA:
2.5		 6bxmA-4basA:
22.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4etp SPINDLE POLE
BODY-ASSOCIATED
PROTEIN VIK1

(Saccharomyces
cerevisiae) 		PF16796
(Microtub_bd) 		5 LEU B 479
LEU B 604
VAL B 603
ILE B 514
ASP B 571
 None
 1.13A 6bxmA-4etpB:
undetectable		 6bxmA-4etpB:
20.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gkp SPINDLE POLE
BODY-ASSOCIATED
PROTEIN VIK1

([Candida]
glabrata) 		PF16796
(Microtub_bd) 		5 LEU A 425
LEU A 544
VAL A 543
ILE A 461
ASP A 511
 None
 1.12A 6bxmA-4gkpA:
undetectable		 6bxmA-4gkpA:
22.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gys ALLOPHANATE
HYDROLASE

(Granulibacter
bethesdensis) 		PF01425
(Amidase) 		5 LEU A 113
GLY A 114
VAL A 207
ILE A  77
ASP A  75
 None
 1.14A 6bxmA-4gysA:
undetectable		 6bxmA-4gysA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hxq ARGINASE-1

(Homo sapiens) 		PF00491
(Arginase) 		5 LEU A  31
SER A 107
VAL A  84
ILE A  11
ASP A  49
 None
 1.18A 6bxmA-4hxqA:
2.1		 6bxmA-4hxqA:
24.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4il5 CYSTEINE SYNTHASE

(Entamoeba
histolytica) 		PF00291
(PALP) 		5 GLY A  23
SER A 189
VAL A 187
ILE A 176
ASP A 179
 None
 1.24A 6bxmA-4il5A:
2.8		 6bxmA-4il5A:
25.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jiv PUTATIVE
UNCHARACTERIZED
PROTEIN

(Vibrio cholerae) 		PF05488
(PAAR_motif) 		5 GLY D  94
VAL D   6
ARG D  74
ILE D   5
ASP D  77
 None
 1.23A 6bxmA-4jivD:
undetectable		 6bxmA-4jivD:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jw1 EFFECTOR PROTEIN B

(Legionella
pneumophila) 		no annotation 5 LEU A  55
GLY A  54
LEU A  93
VAL A  94
ILE A  75
 None
 0.90A 6bxmA-4jw1A:
undetectable		 6bxmA-4jw1A:
19.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k90 EXTRACELLULAR
METALLOPROTEINASE
MEP

(Aspergillus
fumigatus) 		PF02128
(Peptidase_M36) 		5 GLY A 613
VAL A 567
ARG A 584
ILE A 587
ASP A 585
 None
None
None
None
NAG  B 302 ( 3.0A)
 1.25A 6bxmA-4k90A:
undetectable		 6bxmA-4k90A:
22.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mzy NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Enterococcus
faecalis) 		PF04095
(NAPRTase) 		5 LEU A 158
GLY A 314
VAL A 275
ILE A 263
ASP A 264
 None
None
None
None
FMT  A 520 ( 4.5A)
 1.11A 6bxmA-4mzyA:
undetectable		 6bxmA-4mzyA:
23.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0i GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A,
MITOCHONDRIAL

(Saccharomyces
cerevisiae) 		PF01425
(Amidase) 		5 LEU A  92
GLY A  93
VAL A 189
ILE A  55
ASP A  53
 None
 1.13A 6bxmA-4n0iA:
undetectable		 6bxmA-4n0iA:
19.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rtf CHAPERONE PROTEIN
DNAK

(Mycobacterium
tuberculosis) 		PF00012
(HSP70) 		5 LEU D 351
GLY D 348
LEU D 139
ILE D 116
ASP D   8
 None
None
None
None
ATP  D 601 (-3.6A)
 1.24A 6bxmA-4rtfD:
undetectable		 6bxmA-4rtfD:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u4p STRUCTURAL
MAINTENANCE OF
CHROMOSOMES PROTEIN
4

(Homo sapiens) 		PF06470
(SMC_hinge) 		5 GLY B 597
LYS B 607
VAL B 645
ILE B 643
ASP B 641
 None
 1.14A 6bxmA-4u4pB:
undetectable		 6bxmA-4u4pB:
22.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uds MBDR REGULATOR

(Azoarcus sp.
CIB) 		PF00440
(TetR_N) 		5 LEU A 113
VAL A 111
ARG A 138
ILE A  74
ASP A  76
 None
 1.24A 6bxmA-4udsA:
undetectable		 6bxmA-4udsA:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wbt PROBABLE
HISTIDINOL-PHOSPHATE
AMINOTRANSFERASE

(Sinorhizobium
meliloti) 		PF00155
(Aminotran_1_2) 		5 LEU A 116
GLY A 117
LEU A 191
VAL A 192
ASP A 166
 None
 1.20A 6bxmA-4wbtA:
2.3		 6bxmA-4wbtA:
25.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wwx V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1

(Mus musculus) 		PF12940
(RAG1) 		5 PHE B 557
LEU B 672
VAL B 532
ILE B 535
ASP B 536
 None
 1.20A 6bxmA-4wwxB:
undetectable		 6bxmA-4wwxB:
20.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wy9 PUTATIVE MCP-TYPE
SIGNAL TRANSDUCTION
PROTEIN

(Campylobacter
jejuni) 		PF02743
(dCache_1) 		5 GLY A 181
SER A  72
LYS A  69
ILE A 167
ASP A 166
 CL  A 402 ( 4.1A)
None
None
None
None
 1.18A 6bxmA-4wy9A:
undetectable		 6bxmA-4wy9A:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 542
GLY A 541
SER A 564
VAL A 568
ARG A 544
 None
 1.22A 6bxmA-4xi2A:
undetectable		 6bxmA-4xi2A:
20.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xoq COENZYME
F420:L-GLUTAMATE
LIGASE

(Mycobacterium
tuberculosis) 		PF00881
(Nitroreductase) 		5 LEU A 388
GLY A 394
SER A 400
LEU A 310
ILE A 340
 None
None
F42  A 501 (-4.9A)
None
None
 1.15A 6bxmA-4xoqA:
undetectable		 6bxmA-4xoqA:
20.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zwj CHIMERA PROTEIN OF
HUMAN RHODOPSIN,
MOUSE S-ARRESTIN,
AND T4 ENDOLYSIN

(Homo sapiens;
Mus musculus;
Escherichia
virus T4) 		PF00001
(7tm_1)
PF00339
(Arrestin_N)
PF00959
(Phage_lysozyme)
PF02752
(Arrestin_C)
PF10413
(Rhodopsin_N) 		5 GLY A2298
VAL A2150
ARG A2176
ILE A2175
ASP A2031
 None
 1.22A 6bxmA-4zwjA:
undetectable		 6bxmA-4zwjA:
16.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a42 UNCHARACTERIZED
LIPOPROTEIN YFHM

(Escherichia
coli) 		PF00207
(A2M)
PF01835
(A2M_N)
PF07703
(A2M_N_2)
PF11974
(MG1) 		5 PHE A 200
LEU A 289
GLY A 266
LEU A 229
ARG A 201
 None
 1.16A 6bxmA-5a42A:
undetectable		 6bxmA-5a42A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4x REELIN

(Mus musculus) 		PF07974
(EGF_2) 		5 PHE A2457
GLY A2405
LEU A2446
ARG A2456
ASP A2370
 None
 1.09A 6bxmA-5b4xA:
undetectable		 6bxmA-5b4xA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b4x REELIN

(Mus musculus) 		PF07974
(EGF_2) 		5 PHE A2639
GLY A2604
LEU A2628
ARG A2638
ASP A2567
 None
 1.16A 6bxmA-5b4xA:
undetectable		 6bxmA-5b4xA:
17.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5daj NALD

(Pseudomonas
aeruginosa) 		PF00440
(TetR_N)
PF08361
(TetR_C_2) 		5 PHE A 144
LEU A 201
VAL A 202
CYH A 149
ARG A 146
 None
 1.16A 6bxmA-5dajA:
undetectable		 6bxmA-5dajA:
20.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7p CELL DIVISION
CONTROL PROTEIN
CDC48

(Mycolicibacterium
smegmatis) 		PF00004
(AAA)
PF02359
(CDC48_N) 		5 LEU A 640
LEU A 570
ARG A 644
ILE A 617
ASP A 615
 None
 1.09A 6bxmA-5e7pA:
2.4		 6bxmA-5e7pA:
17.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jo9 RIBITOL
2-DEHYDROGENASE

(Bradyrhizobium
japonicum) 		PF00106
(adh_short) 		5 SER A  23
LEU A 222
VAL A 218
ILE A 181
ASP A 232
 None
 1.25A 6bxmA-5jo9A:
3.0		 6bxmA-5jo9A:
20.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m5p PRE-MRNA-SPLICING
HELICASE BRR2

(Saccharomyces
cerevisiae) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		5 LEU A 824
GLY A 823
LEU A 731
VAL A 730
ILE A 740
 None
 1.07A 6bxmA-5m5pA:
2.2		 6bxmA-5m5pA:
11.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mb4 GLCNAC SPECIFIC
LECTIN

(Psathyrella) 		PF13517
(VCBS) 		5 GLY A 295
SER A   6
LEU A 172
ILE A 231
ASP A 241
 None
None
None
None
NA  A 503 (-2.7A)
 1.20A 6bxmA-5mb4A:
undetectable		 6bxmA-5mb4A:
21.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkk MULTIDRUG RESISTANCE
ABC TRANSPORTER
ATP-BINDING AND
PERMEASE PROTEIN

(Thermus
thermophilus) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 LEU A 504
GLY A 500
SER A 557
GLN A 537
ASP A 529
 None
 1.25A 6bxmA-5mkkA:
undetectable		 6bxmA-5mkkA:
20.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mqp GLYCOSIDE HYDROLASE
BT_1002

(Bacteroides
thetaiotaomicron) 		no annotation 5 PHE A 455
LEU A 420
ARG A 413
ILE A 415
ASP A 389
 None
 1.25A 6bxmA-5mqpA:
undetectable		 6bxmA-5mqpA:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nd1 CAPSID PROTEIN

(Rosellinia
necatrix
quadrivirus 1) 		no annotation 5 PHE B 824
LEU B 120
VAL B 857
CYH B 827
ILE B 101
 None
 1.25A 6bxmA-5nd1B:
undetectable		 6bxmA-5nd1B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o3w PEPTIDE CYCLASE 1

(Gypsophila
vaccaria) 		no annotation 5 GLY A 189
SER A 179
VAL A 176
ILE A 158
ASP A 171
 None
 1.21A 6bxmA-5o3wA:
undetectable		 6bxmA-5o3wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o7g ALPHA/BETA HYDROLASE
FAMILY PROTEIN

(Bacillus
coagulans) 		no annotation 5 LEU A 134
GLY A 133
GLN A  33
VAL A  99
ILE A  31
 None
 1.05A 6bxmA-5o7gA:
2.0		 6bxmA-5o7gA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy5 ARYL HYDROCARBON
RECEPTOR NUCLEAR
TRANSLOCATOR
NEURONAL PAS
DOMAIN-CONTAINING
PROTEIN 1

(Mus musculus;
Mus musculus) 		PF00010
(HLH)
PF00989
(PAS)
PF14598
(PAS_11)
PF00010
(HLH)
PF00989
(PAS)
PF08447
(PAS_3) 		5 LEU B 172
SER A 157
GLN B 174
LEU B  72
ILE B  78
 None
 1.20A 6bxmA-5sy5B:
undetectable		 6bxmA-5sy5B:
21.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vni PROTEIN TRANSPORT
PROTEIN SEC23A
PROTEIN TRANSPORT
PROTEIN SEC24A

(Homo sapiens;
Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS)
PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		5 PHE A 189
SER A 269
LEU A 200
ARG A 190
ASP B 575
 None
 1.01A 6bxmA-5vniA:
undetectable		 6bxmA-5vniA:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xdr PRE-MRNA-SPLICING
FACTOR ATP-DEPENDENT
RNA HELICASE DHX15

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF04408
(HA2)
PF07717
(OB_NTP_bind) 		5 GLY A 163
SER A 420
VAL A 418
ILE A 430
ASP A 431
 ADP  A 801 (-3.7A)
None
None
None
ADP  A 801 (-2.5A)
 1.19A 6bxmA-5xdrA:
2.8		 6bxmA-5xdrA:
20.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xya -

(-) 		no annotation 5 GLY A1313
SER A1384
VAL A1376
ARG A1379
ILE A1317
 None
 1.24A 6bxmA-5xyaA:
1.5		 6bxmA-5xyaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yat MITOCHONDRIAL
ALCOHOL
DEHYDROGENASE
ISOZYME III

(Komagataella
phaffii) 		no annotation 5 GLY A 186
LEU A 237
VAL A 234
ILE A 203
ASP A 204
 None
 1.08A 6bxmA-5yatA:
3.3		 6bxmA-5yatA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z2e DIHYDRODIPICOLINATE
REDUCTASE

(Paenisporosarcina
sp. TG-14) 		no annotation 5 PHE A  72
LEU A 119
GLY A 120
VAL A  81
ILE A  97
 None
 1.05A 6bxmA-5z2eA:
3.6		 6bxmA-5z2eA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z7h LYSR FAMILY
TRANSCRIPTIONAL
REGULATOR

(Staphylococcus
aureus) 		no annotation 5 LEU A 177
GLY A 225
SER A 238
GLN A 241
ILE A 221
 None
 1.23A 6bxmA-5z7hA:
3.4		 6bxmA-5z7hA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bxn DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2

(Candidatus
Methanoperedens
nitroreducens) 		no annotation 12 PHE A  58
LEU A 157
GLY A 158
SER A 232
LYS A 234
GLN A 237
LEU A 264
VAL A 265
CYH A 283
ARG A 285
ILE A 286
ASP A 289
 SAM  A 901 ( 3.5A)
SAM  A 901 (-3.8A)
SF4  A 900 ( 3.6A)
SAM  A 901 ( 3.9A)
SAM  A 901 (-4.9A)
SAM  A 901 (-3.0A)
SAM  A 901 (-4.5A)
SAM  A 901 (-4.0A)
SF4  A 900 ( 2.2A)
SAM  A 901 (-4.1A)
SAM  A 901 (-4.7A)
SAM  A 901 (-3.9A)
 0.22A 6bxmA-6bxnA:
41.7		 6bxmA-6bxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cg0 V(D)J
RECOMBINATION-ACTIVA
TING PROTEIN 1

(Mus musculus) 		no annotation 5 LEU A 657
SER A 561
VAL A 532
ILE A 535
ASP A 536
 None
 1.01A 6bxmA-6cg0A:
undetectable		 6bxmA-6cg0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gjt -

(-) 		no annotation 5 LEU A 216
GLY A 215
LEU A 164
VAL A 165
ILE A 211
 None
 1.17A 6bxmA-6gjtA:
undetectable		 6bxmA-6gjtA:
undetectable