SIMILAR PATTERNS OF AMINO ACIDS FOR 6BXL_B_SAMB401_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eye DIHYDROPTEROATE
SYNTHASE I

(Mycobacterium
tuberculosis) 		PF00809
(Pterin_bind) 		5 LEU A 220
GLY A 217
SER A 241
ARG A 233
ASP A  21
 None
None
None
None
PMM  A 301 (-3.3A)
 1.41A 6bxlB-1eyeA:
undetectable		 6bxlB-1eyeA:
22.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gff BACTERIOPHAGE G4
CAPSID PROTEINS GPF,
GPG, GPJ

(Escherichia
virus G4) 		PF02305
(Phage_F) 		5 LEU 1 365
GLY 1 367
SER 1 256
GLN 1 259
ARG 1  55
 None
 1.41A 6bxlB-1gff1:
undetectable		 6bxlB-1gff1:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jr1 INOSINE-5'-MONOPHOSP
HATE DEHYDROGENASE 2

(Cricetulus
griseus) 		PF00478
(IMPDH)
PF00571
(CBS) 		5 LEU A 273
VAL A 350
ARG A 322
VAL A 323
ASP A 364
 None
None
MOA  A1332 (-3.6A)
None
IMP  A1331 (-2.8A)
 1.39A 6bxlB-1jr1A:
undetectable		 6bxlB-1jr1A:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jzt HYPOTHETICAL 27.5
KDA PROTEIN IN
SPX19-GCR2
INTERGENIC REGION

(Saccharomyces
cerevisiae) 		PF03853
(YjeF_N) 		5 LEU A  34
GLY A 219
VAL A 137
VAL A 172
ASP A 173
 None
 1.36A 6bxlB-1jztA:
2.9		 6bxlB-1jztA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p22 F-BOX/WD-REPEAT
PROTEIN 1A

(Homo sapiens) 		PF00400
(WD40)
PF12937
(F-box-like) 		5 LEU A 313
VAL A 393
ARG A 354
VAL A 396
ASP A 397
 None
 1.38A 6bxlB-1p22A:
undetectable		 6bxlB-1p22A:
21.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qr5 PHOSPHOCARRIER
PROTEIN HPR

(Staphylococcus
carnosus) 		PF00381
(PTS-HPr) 		5 LEU A  86
GLY A  85
SER A  46
VAL A  50
VAL A  55
 None
 1.36A 6bxlB-1qr5A:
undetectable		 6bxlB-1qr5A:
13.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0p INTEGRIN ALPHA-L

(Homo sapiens) 		PF00092
(VWA) 		5 LEU A 142
GLY A 138
HIS A 201
VAL A 133
VAL A 171
 None
 1.28A 6bxlB-1t0pA:
3.0		 6bxlB-1t0pA:
18.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tj5 SUCROSE-PHOSPHATASE

(Synechocystis
sp. PCC 6803) 		PF05116
(S6PP) 		5 LEU A 234
GLY A 231
GLN A  25
VAL A  55
VAL A  15
 None
 1.31A 6bxlB-1tj5A:
undetectable		 6bxlB-1tj5A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 LEU B 165
GLY B 163
VAL B  11
VAL B 187
ASP B 188
 None
 1.26A 6bxlB-1tqyB:
undetectable		 6bxlB-1tqyB:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tqy ACTINORHODIN
POLYKETIDE PUTATIVE
BETA-KETOACYL
SYNTHASE 2

(Streptomyces
coelicolor) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 LEU B 165
GLY B 164
VAL B  11
VAL B 187
ASP B 188
 None
 0.99A 6bxlB-1tqyB:
undetectable		 6bxlB-1tqyB:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1x42 HYPOTHETICAL PROTEIN
PH0459

(Pyrococcus
horikoshii) 		PF13419
(HAD_2) 		5 LEU A  14
GLY A  11
VAL A   5
VAL A 178
ASP A 185
 None
 1.24A 6bxlB-1x42A:
undetectable		 6bxlB-1x42A:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfu CALMODULIN-SENSITIVE
ADENYLATE CYCLASE

(Bacillus
anthracis) 		PF03497
(Anthrax_toxA)
PF07737
(ATLF) 		5 LEU A 549
GLY A 578
VAL A 564
VAL A 574
ASP A 491
 None
None
None
None
MG  A 900 (-2.4A)
 1.30A 6bxlB-1xfuA:
undetectable		 6bxlB-1xfuA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zef ALKALINE PHOSPHATASE

(Homo sapiens) 		PF00245
(Alk_phosphatase) 		5 GLY A  93
SER A  80
GLN A 455
VAL A 437
ASP A 316
 SEP  A  92 ( 2.4A)
None
None
None
ZN  A 901 ( 1.9A)
 1.23A 6bxlB-1zefA:
undetectable		 6bxlB-1zefA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bw3 TRANSPOSASE
TRANSPOSASE

(Musca
domestica;
Musca domestica) 		PF05699
(Dimer_Tnp_hAT)
PF10683
(DBD_Tnp_Hermes)
PF10683
(DBD_Tnp_Hermes) 		5 SER B 148
VAL B 151
ARG A 107
VAL A 102
ASP A 105
 None
 1.41A 6bxlB-2bw3B:
undetectable		 6bxlB-2bw3B:
13.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cbf COBALT-PRECORRIN-4
TRANSMETHYLASE

(Bacillus
megaterium) 		PF00590
(TP_methylase) 		5 GLY A  31
SER A  65
VAL A  50
VAL A  99
ASP A  54
 None
 1.40A 6bxlB-2cbfA:
2.0		 6bxlB-2cbfA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0o DIOL
DEHYDRATASE-REACTIVA
TING FACTOR LARGE
SUBUNIT

(Klebsiella
oxytoca) 		PF08841
(DDR) 		5 LEU A 600
GLY A 597
VAL A  57
VAL A  16
ASP A   8
 None
None
None
None
MG  A1003 ( 4.1A)
 1.04A 6bxlB-2d0oA:
undetectable		 6bxlB-2d0oA:
21.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d5l DIPEPTIDYL
AMINOPEPTIDASE IV,
PUTATIVE

(Porphyromonas
gingivalis) 		PF00326
(Peptidase_S9)
PF00930
(DPPIV_N) 		5 LEU A 670
GLY A 668
VAL A 583
VAL A 619
ASP A 618
 None
 1.27A 6bxlB-2d5lA:
undetectable		 6bxlB-2d5lA:
19.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ipi ACLACINOMYCIN
OXIDOREDUCTASE
(AKNOX)

(Streptomyces
galilaeus) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 GLY A  60
GLN A  55
VAL A  14
VAL A  39
ASP A  38
 None
 1.31A 6bxlB-2ipiA:
undetectable		 6bxlB-2ipiA:
22.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j86 PROTEIN
SERINE-THREONINE
PHOSPHATASE

(Synechococcus
elongatus) 		PF13672
(PP2C_2) 		5 GLY A 228
SER A 192
VAL A 235
VAL A 221
ASP A 222
 None
 1.36A 6bxlB-2j86A:
undetectable		 6bxlB-2j86A:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oi6 BIFUNCTIONAL PROTEIN
GLMU

(Escherichia
coli) 		PF00132
(Hexapep)
PF12804
(NTP_transf_3) 		5 LEU A 339
GLY A 356
VAL A 415
VAL A 401
ASP A 400
 None
 1.34A 6bxlB-2oi6A:
undetectable		 6bxlB-2oi6A:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rkv TRICHOTHECENE
3-O-ACETYLTRANSFERAS
E

(Fusarium
graminearum) 		PF02458
(Transferase) 		5 TYR A 388
LEU A 392
GLY A 391
ARG A 176
ASP A 178
 None
 1.31A 6bxlB-2rkvA:
undetectable		 6bxlB-2rkvA:
23.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2whx SERINE
PROTEASE/NTPASE/HELI
CASE NS3

(Dengue virus) 		PF00949
(Peptidase_S7)
PF07652
(Flavi_DEAD) 		5 GLY A 253
HIS A 251
VAL A 208
VAL A 257
ASP A 258
 None
 1.24A 6bxlB-2whxA:
3.5		 6bxlB-2whxA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wu5 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT

(Escherichia
coli) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 TYR A 150
LEU A 145
GLY A 142
SER A  37
VAL A  39
 None
None
None
FAD  A 601 (-2.7A)
FAD  A 601 (-4.1A)
 1.37A 6bxlB-2wu5A:
3.3		 6bxlB-2wu5A:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Thermosynechococcus
elongatus) 		PF00148
(Oxidored_nitro) 		5 LEU A 205
GLY A 203
SER A  37
VAL A 102
VAL A 150
 None
 1.38A 6bxlB-2xdqA:
2.4		 6bxlB-2xdqA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xdq LIGHT-INDEPENDENT
PROTOCHLOROPHYLLIDE
REDUCTASE SUBUNIT N

(Thermosynechococcus
elongatus) 		PF00148
(Oxidored_nitro) 		5 LEU A 205
GLY A 203
SER A  37
VAL A 150
ASP A 148
 None
 1.40A 6bxlB-2xdqA:
2.4		 6bxlB-2xdqA:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xsg CCMAN5

(Cellulosimicrobium
cellulans) 		PF07971
(Glyco_hydro_92) 		5 TYR A 365
GLY A 743
VAL A 689
VAL A 736
ASP A 737
 None
 1.13A 6bxlB-2xsgA:
undetectable		 6bxlB-2xsgA:
16.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y3s TAML

(Streptomyces
sp. 307-9) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 GLY A 190
HIS A 491
VAL A 167
VAL A 157
ASP A 484
 FAD  A 600 (-4.0A)
FAD  A 600 ( 4.6A)
None
None
None
 1.40A 6bxlB-2y3sA:
undetectable		 6bxlB-2y3sA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bry TBUX

(Ralstonia
pickettii) 		PF03349
(Toluene_X) 		5 LEU A  39
GLY A  38
HIS A 145
SER A  47
ARG A  90
 None
 1.29A 6bxlB-3bryA:
undetectable		 6bxlB-3bryA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c0b CONSERVED ARCHAEAL
PROTEIN Q6M145

(Methanococcus
maripaludis) 		PF01968
(Hydantoinase_A) 		5 LEU A 284
GLY A 135
VAL A 279
VAL A 132
ASP A 140
 None
 1.12A 6bxlB-3c0bA:
undetectable		 6bxlB-3c0bA:
22.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8f PYRUVATE
FORMATE-LYASE
1-ACTIVATING ENZYME

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF13353
(Fer4_12) 		5 LEU A 204
GLY A 205
HIS A 207
CYH A  36
ASP A  40
 None
None
None
SF4  A 500 (-2.2A)
None
 1.36A 6bxlB-3c8fA:
undetectable		 6bxlB-3c8fA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ctz XAA-PRO
AMINOPEPTIDASE 1

(Homo sapiens) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		5 HIS A 485
VAL A 565
ARG A 535
VAL A 427
ASP A 415
 P6G  A 628 (-3.5A)
None
P6G  A 628 ( 4.3A)
None
MN  A 625 (-1.9A)
 1.32A 6bxlB-3ctzA:
undetectable		 6bxlB-3ctzA:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gcf TERMINAL OXYGENASE
COMPONENT OF
CARBAZOLE
1,9A-DIOXYGENASE

(Nocardioides
aromaticivorans) 		PF00355
(Rieske)
PF11723
(Aromatic_hydrox) 		5 LEU A 179
GLY A 180
HIS A 298
VAL A 229
VAL A 268
 None
 1.26A 6bxlB-3gcfA:
undetectable		 6bxlB-3gcfA:
24.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jqy POLYSIALIC ACID
O-ACETYLTRANSFERASE

(Escherichia
coli) 		no annotation 5 LEU B  75
GLY B  96
VAL B 172
VAL B 139
ASP B 138
 None
 1.09A 6bxlB-3jqyB:
undetectable		 6bxlB-3jqyB:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 1

(Homo sapiens) 		PF00899
(ThiF) 		5 LEU A  28
GLY A  27
SER A  37
ARG A 321
ASP A 322
 None
 1.29A 6bxlB-3kydA:
2.6		 6bxlB-3kydA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kyd SUMO-ACTIVATING
ENZYME SUBUNIT 1

(Homo sapiens) 		PF00899
(ThiF) 		5 LEU A  44
GLY A  43
VAL A 302
VAL A 158
ASP A 157
 None
 1.29A 6bxlB-3kydA:
2.6		 6bxlB-3kydA:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2z BIRA BIFUNCTIONAL
PROTEIN

(Mycobacterium
tuberculosis) 		PF02237
(BPL_C)
PF03099
(BPL_LplA_LipB) 		5 LEU A 217
GLY A 125
VAL A 155
VAL A 109
ASP A 111
 None
 1.36A 6bxlB-3l2zA:
undetectable		 6bxlB-3l2zA:
22.48
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lzd DPH2

(Pyrococcus
horikoshii) 		PF01866
(Diphthamide_syn) 		11 LEU A 161
GLY A 162
HIS A 184
SER A 236
LYS A 238
GLN A 241
VAL A 269
CYH A 287
ARG A 289
VAL A 290
ASP A 293
 SO4  A 344 (-3.8A)
SO4  A 344 (-3.5A)
SO4  A 344 (-4.2A)
None
None
SF4  A 343 ( 4.4A)
None
SF4  A 343 (-2.3A)
SO4  A 344 (-4.0A)
None
None
 0.59A 6bxlB-3lzdA:
50.5		 6bxlB-3lzdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lzd DPH2

(Pyrococcus
horikoshii) 		PF01866
(Diphthamide_syn) 		9 TYR A  56
LEU A 161
GLY A 162
HIS A 184
LYS A 238
GLN A 241
CYH A 287
ARG A 289
ASP A 293
 None
SO4  A 344 (-3.8A)
SO4  A 344 (-3.5A)
SO4  A 344 (-4.2A)
None
SF4  A 343 ( 4.4A)
SF4  A 343 (-2.3A)
SO4  A 344 (-4.0A)
None
 0.82A 6bxlB-3lzdA:
50.5		 6bxlB-3lzdA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qwu DNA LIGASE

(Aquifex
aeolicus) 		PF09414
(RNA_ligase) 		5 LEU A  95
GLY A  99
VAL A   7
ARG A  28
VAL A  16
 None
 1.39A 6bxlB-3qwuA:
undetectable		 6bxlB-3qwuA:
23.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r3s OXIDOREDUCTASE

(Salmonella
enterica) 		PF13561
(adh_short_C2) 		5 GLY A  99
VAL A  54
ARG A 100
VAL A  76
ASP A  75
 None
 1.34A 6bxlB-3r3sA:
2.3		 6bxlB-3r3sA:
24.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rq0 GLYCOSYL HYDROLASES
FAMILY PROTEIN 16

(Mycolicibacterium
smegmatis) 		PF00722
(Glyco_hydro_16) 		5 GLY A 174
SER A 220
VAL A 216
VAL A 168
ASP A 152
 PG4  A 274 ( 4.5A)
None
None
None
GOL  A 278 (-3.8A)
 1.20A 6bxlB-3rq0A:
undetectable		 6bxlB-3rq0A:
21.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rsc CALG2

(Micromonospora
echinospora) 		PF04101
(Glyco_tran_28_C) 		5 LEU A 336
GLY A 337
VAL A 297
VAL A 359
ASP A 362
 None
 1.07A 6bxlB-3rscA:
2.8		 6bxlB-3rscA:
24.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slc ACETATE KINASE

(Salmonella
enterica) 		PF00871
(Acetate_kinase) 		5 TYR A 162
GLY A 231
GLN A 155
ARG A 178
ASP A 227
 None
 1.23A 6bxlB-3slcA:
undetectable		 6bxlB-3slcA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3slc ACETATE KINASE

(Salmonella
enterica) 		PF00871
(Acetate_kinase) 		5 TYR A 162
LEU A 232
GLY A 231
ARG A 178
ASP A 227
 None
 1.11A 6bxlB-3slcA:
undetectable		 6bxlB-3slcA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swd UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Escherichia
coli) 		PF00275
(EPSP_synthase) 		5 TYR A 393
LEU A  47
GLY A 398
VAL A 389
ASP A 369
 None
 1.38A 6bxlB-3swdA:
undetectable		 6bxlB-3swdA:
24.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3swe UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE

(Haemophilus
influenzae) 		PF00275
(EPSP_synthase) 		5 TYR A 395
LEU A  47
GLY A 400
VAL A 391
ASP A 371
 GOL  A 506 (-4.9A)
None
None
None
None
 1.41A 6bxlB-3sweA:
undetectable		 6bxlB-3sweA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t34 DYNAMIN-RELATED
PROTEIN 1A, LINKER,
DYNAMIN-RELATED
PROTEIN 1A

(Arabidopsis
thaliana) 		PF00350
(Dynamin_N)
PF01031
(Dynamin_M) 		5 TYR A 169
LEU A 146
GLY A 145
VAL A 124
ASP A 142
 None
None
ALF  A1001 (-3.5A)
None
MG  A1002 ( 3.9A)
 1.38A 6bxlB-3t34A:
undetectable		 6bxlB-3t34A:
24.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tqr PHOSPHORIBOSYLGLYCIN
AMIDE
FORMYLTRANSFERASE

(Coxiella
burnetii) 		PF00551
(Formyl_trans_N) 		5 LEU A 158
GLY A 137
HIS A 136
VAL A 184
VAL A 140
 None
 1.28A 6bxlB-3tqrA:
1.8		 6bxlB-3tqrA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3twd BIFUNCTIONAL PROTEIN
GLMU

(Escherichia
coli) 		PF00132
(Hexapep) 		5 LEU A 339
GLY A 356
VAL A 415
VAL A 401
ASP A 400
 None
 1.36A 6bxlB-3twdA:
undetectable		 6bxlB-3twdA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uaq LBPB B-LOBE

(Moraxella bovis) 		PF01298
(TbpB_B_D)
PF17484
(TbpB_A) 		5 TYR A 156
LEU A  55
GLY A  56
VAL A 121
ASP A 160
 None
 1.11A 6bxlB-3uaqA:
undetectable		 6bxlB-3uaqA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vgf MALTO-OLIGOSYLTREHAL
OSE TREHALOHYDROLASE

(Sulfolobus
solfataricus) 		PF00128
(Alpha-amylase)
PF09071
(Alpha-amyl_C) 		5 TYR A  56
LEU A  32
GLY A  31
VAL A  11
VAL A  50
 None
 1.32A 6bxlB-3vgfA:
undetectable		 6bxlB-3vgfA:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vnk XYLOSE ISOMERASE
DOMAIN PROTEIN TIM
BARREL

([Clostridium]
cellulolyticum) 		PF01261
(AP_endonuc_2) 		5 TYR A 204
LEU A 182
VAL A 173
VAL A 178
ASP A 146
 None
 1.23A 6bxlB-3vnkA:
undetectable		 6bxlB-3vnkA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4arc LEUCINE--TRNA LIGASE

(Escherichia
coli) 		PF00133
(tRNA-synt_1)
PF08264
(Anticodon_1)
PF13603
(tRNA-synt_1_2) 		6 LEU A 115
GLY A 116
HIS A 767
GLN A  75
VAL A  73
ASP A 783
 None
 1.47A 6bxlB-4arcA:
2.1		 6bxlB-4arcA:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d9r COMPLEMENT FACTOR D

(Homo sapiens) 		PF00089
(Trypsin) 		5 GLY A  19
SER A 215
VAL A 213
VAL A 138
ASP A 137
 None
 1.32A 6bxlB-4d9rA:
undetectable		 6bxlB-4d9rA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewp 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Micrococcus
luteus) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 GLY A 140
HIS A   8
VAL A 147
VAL A 145
ASP A  85
 None
 1.31A 6bxlB-4ewpA:
1.8		 6bxlB-4ewpA:
24.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fye SIDF, INHIBITOR OF
GROWTH FAMILY,
MEMBER 3

(Legionella
pneumophila) 		no annotation 5 LEU A 548
HIS A 549
GLN A 541
VAL A 497
ASP A 384
 None
 1.14A 6bxlB-4fyeA:
3.4		 6bxlB-4fyeA:
20.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g9y PCAV TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF13463
(HTH_27) 		5 LEU A  92
GLY A  49
GLN A  52
VAL A  69
VAL A  40
 None
 1.39A 6bxlB-4g9yA:
undetectable		 6bxlB-4g9yA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gs1 DYP-TYPE PEROXIDASE

(Thermobifida
cellulosilytica) 		PF04261
(Dyp_perox) 		5 LEU A 372
GLY A 354
SER A 273
VAL A 256
VAL A 351
 None
 1.39A 6bxlB-4gs1A:
undetectable		 6bxlB-4gs1A:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gxw ADENOSINE DEAMINASE

(Burkholderia
ambifaria) 		PF00962
(A_deaminase) 		5 GLY A 337
VAL A 230
ARG A 237
VAL A 238
ASP A 239
 None
 1.29A 6bxlB-4gxwA:
undetectable		 6bxlB-4gxwA:
22.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvm TLMII

(Streptoalloteichus
hindustanus) 		PF00668
(Condensation) 		5 GLY A  19
SER A 275
VAL A 298
VAL A 335
ASP A 334
 None
 1.22A 6bxlB-4hvmA:
undetectable		 6bxlB-4hvmA:
21.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iig BETA-GLUCOSIDASE 1

(Aspergillus
aculeatus) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 LEU A 263
GLY A 294
VAL A  60
VAL A 330
ASP A 332
 None
 1.35A 6bxlB-4iigA:
4.2		 6bxlB-4iigA:
17.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nox EUKARYOTIC
TRANSLATION
INITIATION FACTOR 3
SUBUNIT B

(Chaetomium
thermophilum) 		PF08662
(eIF2A) 		5 GLY A 581
HIS A 603
VAL A 594
VAL A 585
ASP A 584
 None
 1.05A 6bxlB-4noxA:
undetectable		 6bxlB-4noxA:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pq9 BETA-1,3-GLUCANASE

(Mycobacterium
marinum) 		PF00722
(Glyco_hydro_16) 		5 GLY A 166
SER A 212
VAL A 208
VAL A 160
ASP A 144
 None
None
None
None
BTB  A 303 (-3.8A)
 1.18A 6bxlB-4pq9A:
undetectable		 6bxlB-4pq9A:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qg5 PUTATIVE
PHOSPHOGLUCOMUTASE

(Leishmania
major) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		5 TYR A 132
LEU A  89
GLY A  56
SER A  73
VAL A  35
 None
 1.36A 6bxlB-4qg5A:
undetectable		 6bxlB-4qg5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnc ESTERASE

(Rhodococcus sp.
ECU1013) 		PF12697
(Abhydrolase_6) 		5 TYR A 110
LEU A 105
GLY A 103
VAL A  85
VAL A  28
 None
 1.38A 6bxlB-4rncA:
undetectable		 6bxlB-4rncA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rnc ESTERASE

(Rhodococcus sp.
ECU1013) 		PF12697
(Abhydrolase_6) 		5 TYR A 110
LEU A 105
GLY A 104
VAL A  85
VAL A  28
 None
 1.09A 6bxlB-4rncA:
undetectable		 6bxlB-4rncA:
25.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rtf CHAPERONE PROTEIN
DNAK

(Mycobacterium
tuberculosis) 		PF00012
(HSP70) 		5 GLY D  10
SER D 179
VAL D 168
VAL D 313
ASP D 342
 ATP  D 601 (-3.0A)
None
None
None
None
 1.35A 6bxlB-4rtfD:
undetectable		 6bxlB-4rtfD:
24.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s2t PROTEIN APP-1

(Caenorhabditis
elegans) 		PF00557
(Peptidase_M24)
PF01321
(Creatinase_N)
PF16188
(Peptidase_M24_C)
PF16189
(Creatinase_N_2) 		5 HIS P 483
VAL P 562
ARG P 534
VAL P 425
ASP P 413
 None
None
None
None
ZN  P 701 ( 2.2A)
 1.40A 6bxlB-4s2tP:
undetectable		 6bxlB-4s2tP:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wiw GLYCOSIDE HYDROLASE
FAMILY 18

(Desulfitobacterium
hafniense) 		PF00704
(Glyco_hydro_18) 		5 TYR A 348
GLY A 669
SER A 345
GLN A 347
VAL A 663
 None
 1.31A 6bxlB-4wiwA:
undetectable		 6bxlB-4wiwA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xdq GLYCOSIDE HYDROLASE
FAMILY PROTEIN

(Mycolicibacterium
thermoresistibile) 		PF00722
(Glyco_hydro_16) 		5 GLY A 167
SER A 213
VAL A 209
VAL A 161
ASP A 145
 None
None
None
None
EDO  A 307 ( 4.3A)
 1.18A 6bxlB-4xdqA:
undetectable		 6bxlB-4xdqA:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		5 LEU A 542
GLY A 541
SER A 564
VAL A 568
ARG A 544
 None
 1.33A 6bxlB-4xi2A:
undetectable		 6bxlB-4xi2A:
24.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y7d ALPHA/BETA HYDROLASE
FOLD PROTEIN

(Nakamurella
multipartita) 		PF00561
(Abhydrolase_1) 		5 TYR A  68
SER A 109
GLN A  82
VAL A  36
ASP A  23
 None
 1.25A 6bxlB-4y7dA:
1.9		 6bxlB-4y7dA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b2g ENDOLYSIN,CLAUDIN-4

(Homo sapiens;
Escherichia
virus T4) 		PF00822
(PMP22_Claudin)
PF00959
(Phage_lysozyme) 		5 LEU A1176
GLY A1340
SER A1250
VAL A1253
VAL A1287
 None
 1.38A 6bxlB-5b2gA:
undetectable		 6bxlB-5b2gA:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5by6 THYMIDYLATE SYNTHASE

(Trichinella
spiralis) 		PF00303
(Thymidylat_synt) 		5 GLY A 214
HIS A 255
SER A 223
VAL A  78
VAL A  73
 None
 1.37A 6bxlB-5by6A:
undetectable		 6bxlB-5by6A:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo sapiens) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		5 HIS A 203
SER A 324
GLN A 252
VAL A 288
ASP A 286
 None
 1.38A 6bxlB-5clwA:
undetectable		 6bxlB-5clwA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5do7 ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
8

(Homo sapiens) 		PF00005
(ABC_tran)
PF01061
(ABC2_membrane) 		5 TYR B 479
LEU B 486
GLY B 485
SER B 222
VAL B 151
 None
 1.30A 6bxlB-5do7B:
undetectable		 6bxlB-5do7B:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dvh PCPI-3

(Solanum
tuberosum) 		PF00197
(Kunitz_legume) 		5 TYR A 150
VAL A 115
ARG A 149
VAL A 167
ASP A 166
 None
 1.37A 6bxlB-5dvhA:
undetectable		 6bxlB-5dvhA:
18.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dxd PUTATIVE
BETA-GLUCANASE

(Mycobacteroides
abscessus) 		PF00722
(Glyco_hydro_16) 		5 GLY A 165
SER A 211
VAL A 207
VAL A 159
ASP A 143
 None
 1.18A 6bxlB-5dxdA:
undetectable		 6bxlB-5dxdA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fhz ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3

(Homo sapiens) 		PF00171
(Aldedh) 		5 SER A 399
LYS A 378
VAL A 331
CYH A 381
VAL A 335
 None
 1.39A 6bxlB-5fhzA:
2.9		 6bxlB-5fhzA:
23.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fjj BETA-GLUCOSIDASE

(Aspergillus
oryzae) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		5 LEU A 264
GLY A 295
VAL A  61
VAL A 331
ASP A 333
 None
 1.36A 6bxlB-5fjjA:
3.7		 6bxlB-5fjjA:
18.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA

(Homo sapiens) 		no annotation 5 LEU B 348
GLY B 349
VAL B 320
CYH B 353
VAL B 301
 None
 1.33A 6bxlB-5iz5B:
undetectable		 6bxlB-5iz5B:
19.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jb3 30S RIBOSOMAL
PROTEIN S10

(Pyrococcus
abyssi) 		PF00338
(Ribosomal_S10) 		5 LEU L  72
VAL L  90
ARG L  71
VAL L  19
ASP L  17
 None
None
G  21112 ( 4.0A)
None
G  21112 ( 4.7A)
 1.25A 6bxlB-5jb3L:
undetectable		 6bxlB-5jb3L:
16.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jjq AMP-DEPENDENT
SYNTHETASE AND
LIGASE

(Streptomyces
sp. ML694-90F3) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 GLY A 341
HIS A 342
VAL A 331
VAL A 327
ASP A 326
 None
 1.28A 6bxlB-5jjqA:
3.4		 6bxlB-5jjqA:
22.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jkn PROTEIN FAM63A

(Homo sapiens) 		PF04424
(MINDY_DUB) 		5 LEU A 281
GLY A 280
SER A 246
VAL A 242
VAL A 253
 None
 1.17A 6bxlB-5jknA:
undetectable		 6bxlB-5jknA:
20.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvh 50S RIBOSOMAL
PROTEIN L13

(Deinococcus
radiodurans) 		PF00572
(Ribosomal_L13) 		5 HIS G  66
VAL G  82
ARG G  61
VAL G  80
ASP G  78
 None
 1.28A 6bxlB-5jvhG:
undetectable		 6bxlB-5jvhG:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		5 GLY A 485
HIS A 487
LYS A 498
CYH A 482
ASP A 533
 None
 1.30A 6bxlB-5l46A:
3.5		 6bxlB-5l46A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdn DNA POLYMERASE

(Pyrobaculum
calidifontis) 		PF00136
(DNA_pol_B)
PF03104
(DNA_pol_B_exo1) 		5 GLY A 723
VAL A 735
ARG A 728
VAL A 719
ASP A 742
 None
 1.29A 6bxlB-5mdnA:
undetectable		 6bxlB-5mdnA:
18.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mu7 COATOMER SUBUNIT
BETA

(Chaetomium
thermophilum) 		PF01602
(Adaptin_N) 		5 TYR A 375
VAL A 325
ARG A 335
VAL A 333
ASP A 332
 None
 1.39A 6bxlB-5mu7A:
undetectable		 6bxlB-5mu7A:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n4a INTRAFLAGELLAR
TRANSPORT PROTEIN 80

(Chlamydomonas
reinhardtii) 		no annotation 5 LEU A 110
HIS A  61
VAL A 189
VAL A 192
ASP A 193
 None
 1.31A 6bxlB-5n4aA:
undetectable		 6bxlB-5n4aA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum) 		no annotation 5 GLY A1029
SER A 901
LYS A 921
GLN A 937
ASP A1032
 None
 1.35A 6bxlB-5ngyA:
undetectable		 6bxlB-5ngyA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nue MALATE DEHYDROGENASE
1, CYTOPLASMIC

(Arabidopsis
thaliana) 		no annotation 5 LEU A 260
GLY A 261
SER A 154
VAL A 272
VAL A 290
 None
 1.41A 6bxlB-5nueA:
3.0		 6bxlB-5nueA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5umg DIHYDROPTEROATE
SYNTHASE

(Klebsiella
pneumoniae) 		PF00809
(Pterin_bind) 		5 TYR A 281
LEU A 204
GLY A 205
HIS A 208
ARG A 280
 None
 1.35A 6bxlB-5umgA:
undetectable		 6bxlB-5umgA:
24.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v44 SACSIN

(Homo sapiens) 		no annotation 5 GLY A 325
VAL A 330
ARG A 321
VAL A 320
ASP A 134
 None
None
GOL  A 403 ( 4.9A)
None
None
 1.40A 6bxlB-5v44A:
undetectable		 6bxlB-5v44A:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wdu BNAB 35O22 FAB LIGHT
CHAIN

(Homo sapiens) 		no annotation 5 TYR I  86
GLY I  64
SER I   7
VAL I  11
VAL I  19
 None
 1.04A 6bxlB-5wduI:
undetectable		 6bxlB-5wduI:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
US5

(Toxoplasma
gondii) 		PF00333
(Ribosomal_S5)
PF03719
(Ribosomal_S5_C) 		5 LEU C 196
GLY C 197
SER C 143
VAL C 112
ASP C  87
 None
 1.36A 6bxlB-5xxuC:
undetectable		 6bxlB-5xxuC:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bwe PUTATIVE FIMBRIAL
ASSOCIATED
SORTASE-LIKE PROTEIN

(Corynebacterium
diphtheriae) 		no annotation 5 LEU A 208
VAL A 175
ARG A 235
VAL A 194
ASP A 195
 None
 0.99A 6bxlB-6bweA:
undetectable		 6bxlB-6bweA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bxn DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2

(Candidatus
Methanoperedens
nitroreducens) 		no annotation 10 LEU A 157
GLY A 158
HIS A 180
SER A 232
LYS A 234
GLN A 237
VAL A 265
CYH A 283
ARG A 285
ASP A 289
 SAM  A 901 (-3.8A)
SF4  A 900 ( 3.6A)
SAM  A 901 (-4.2A)
SAM  A 901 ( 3.9A)
SAM  A 901 (-4.9A)
SAM  A 901 (-3.0A)
SAM  A 901 (-4.0A)
SF4  A 900 ( 2.2A)
SAM  A 901 (-4.1A)
SAM  A 901 (-3.9A)
 0.54A 6bxlB-6bxnA:
13.6		 6bxlB-6bxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ck9 35O22 SCFV LIGHT
CHAIN PORTION

(Homo sapiens) 		no annotation 5 TYR E  86
GLY E  64
SER E   7
VAL E  11
VAL E  19
 None
 1.33A 6bxlB-6ck9E:
undetectable		 6bxlB-6ck9E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE ALPHA
CHAIN, MITOCHONDRIAL

(Trypanosoma
brucei) 		no annotation 5 LEU A 119
GLY A 120
SER A 218
VAL A 226
VAL A 115
 None
 1.33A 6bxlB-6f5dA:
3.4		 6bxlB-6f5dA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ghd


(;
) 		no annotation
no annotation 		5 TYR G  34
VAL D  51
ARG G  31
VAL G  27
ASP G   9
 None
 1.21A 6bxlB-6ghdG:
undetectable		 6bxlB-6ghdG:
undetectable