SIMILAR PATTERNS OF AMINO ACIDS FOR 6BXL_A_SAMA401

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6d THERMOSOME (ALPHA
SUBUNIT)

(Thermoplasma
acidophilum) 		PF00118
(Cpn60_TCP1) 		5 LEU A 107
GLY A 104
SER A  85
VAL A  38
ASP A  36
 None
 1.24A 6bxlA-1a6dA:
0.0		 6bxlA-1a6dA:
23.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dqw OROTIDINE
5'-PHOSPHATE
DECARBOXYLASE

(Saccharomyces
cerevisiae) 		PF00215
(OMPdecase) 		5 LEU A  65
SER A  81
LYS A  78
ASP A 117
ASP A  91
 None
 1.50A 6bxlA-1dqwA:
0.0		 6bxlA-1dqwA:
21.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eq2 ADP-L-GLYCERO-D-MANN
OHEPTOSE 6-EPIMERASE

(Escherichia
coli) 		PF01370
(Epimerase) 		5 TYR A 213
LEU A 235
GLY A 236
SER A 183
VAL A 295
 None
 1.47A 6bxlA-1eq2A:
0.0		 6bxlA-1eq2A:
23.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jc9 TECHYLECTIN-5A

(Tachypleus
tridentatus) 		PF00147
(Fibrinogen_C) 		5 LEU A 227
GLY A 239
HIS A 233
SER A 193
ASP A 200
 None
None
None
None
CA  A 301 (-2.6A)
 1.23A 6bxlA-1jc9A:
undetectable		 6bxlA-1jc9A:
20.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogo DEXTRANASE

(Talaromyces
minioluteus) 		PF03718
(Glyco_hydro_49)
PF17433
(Glyco_hydro_49N) 		5 GLY X  88
HIS X 416
SER X 320
GLN X 304
ASP X 317
 None
 1.39A 6bxlA-1ogoX:
undetectable		 6bxlA-1ogoX:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q6y HYPOTHETICAL PROTEIN
YFDW

(Escherichia
coli) 		PF02515
(CoA_transf_3) 		5 LEU A 179
GLY A 175
SER A  67
GLN A  26
ASP A 171
 None
None
None
None
COA  A 500 (-3.0A)
 1.40A 6bxlA-1q6yA:
2.8		 6bxlA-1q6yA:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1txg GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]

(Archaeoglobus
fulgidus) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		5 LEU A  76
SER A 189
LYS A 105
ASP A 250
VAL A 153
 None
None
SO4  A1003 (-2.7A)
SO4  A1003 ( 4.3A)
None
 1.33A 6bxlA-1txgA:
2.3		 6bxlA-1txgA:
25.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2myi EXODEOXYRIBONUCLEASE
III

(Pseudomonas sp.
Lz4W) 		PF03372
(Exo_endo_phos) 		5 LEU A 107
GLY A 147
SER A  72
ASP A  29
CYH A  32
 None
 1.32A 6bxlA-2myiA:
undetectable		 6bxlA-2myiA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p88 MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME
FAMILY PROTEIN

(Bacillus cereus) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A  24
GLN A 194
ASP A 224
VAL A  54
ASP A  52
 None
 1.44A 6bxlA-2p88A:
0.6		 6bxlA-2p88A:
24.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wnp FICOLIN-1

(Homo sapiens) 		PF00147
(Fibrinogen_C) 		5 LEU F 262
GLY F 274
HIS F 268
SER F 228
ASP F 235
 None
None
None
None
CA  F1298 (-2.6A)
 1.26A 6bxlA-2wnpF:
undetectable		 6bxlA-2wnpF:
18.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0i MALATE DEHYDROGENASE

(Archaeoglobus
fulgidus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 GLY A  33
SER A  91
LYS A  23
VAL A  52
ASP A  53
 None
None
None
None
NAI  A1000 (-2.8A)
 1.48A 6bxlA-2x0iA:
2.4		 6bxlA-2x0iA:
25.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8f PYRUVATE
FORMATE-LYASE
1-ACTIVATING ENZYME

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF13353
(Fer4_12) 		5 LEU A 204
GLY A 205
HIS A 207
CYH A  36
ASP A  40
 None
None
None
SF4  A 500 (-2.2A)
None
 1.23A 6bxlA-3c8fA:
undetectable		 6bxlA-3c8fA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c8f PYRUVATE
FORMATE-LYASE
1-ACTIVATING ENZYME

(Escherichia
coli) 		PF04055
(Radical_SAM)
PF13353
(Fer4_12) 		5 LEU A 204
GLY A 205
HIS A 207
SER A  76
ASP A  40
 None
None
None
MT2  A 501 ( 4.0A)
None
 1.21A 6bxlA-3c8fA:
undetectable		 6bxlA-3c8fA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ct7 D-ALLULOSE-6-PHOSPHA
TE 3-EPIMERASE

(Escherichia
coli) 		PF00834
(Ribul_P_3_epim) 		5 LEU A 199
GLY A 195
CYH A 176
VAL A 172
ASP A 173
 None
SO4  A 233 (-3.4A)
None
None
MG  A 232 (-3.0A)
 1.32A 6bxlA-3ct7A:
undetectable		 6bxlA-3ct7A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j9o INTRACELLULAR GROWTH
LOCUS PROTEIN A
INTRACELLULAR GROWTH
LOCUS PROTEIN B

(Francisella
tularensis;
Francisella
tularensis) 		PF05591
(T6SS_VipA)
PF05943
(VipB) 		5 LEU B 167
GLY B 168
ASP A  45
VAL B 125
ASP A  37
 None
 1.40A 6bxlA-3j9oB:
undetectable		 6bxlA-3j9oB:
20.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jru PROBABLE CYTOSOL
AMINOPEPTIDASE

(Xanthomonas
oryzae) 		no annotation 5 GLY B 347
SER B 334
LYS B 336
CYH B 352
ASP B 368
 CO3  B 491 (-3.1A)
None
None
None
None
 1.41A 6bxlA-3jruB:
2.2		 6bxlA-3jruB:
22.13
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lzd DPH2

(Pyrococcus
horikoshii) 		PF01866
(Diphthamide_syn) 		10 TYR A  56
LEU A 161
GLY A 162
HIS A 184
SER A 236
LYS A 238
GLN A 241
ASP A 268
CYH A 287
VAL A 290
 None
SO4  A 344 (-3.8A)
SO4  A 344 (-3.5A)
SO4  A 344 (-4.2A)
None
None
SF4  A 343 ( 4.4A)
None
SF4  A 343 (-2.3A)
None
 0.45A 6bxlA-3lzdA:
52.9		 6bxlA-3lzdA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3lzd DPH2

(Pyrococcus
horikoshii) 		PF01866
(Diphthamide_syn) 		10 TYR A  56
LEU A 161
GLY A 162
HIS A 184
SER A 236
LYS A 238
GLN A 241
CYH A 287
VAL A 290
ASP A 293
 None
SO4  A 344 (-3.8A)
SO4  A 344 (-3.5A)
SO4  A 344 (-4.2A)
None
None
SF4  A 343 ( 4.4A)
SF4  A 343 (-2.3A)
None
None
 0.46A 6bxlA-3lzdA:
52.9		 6bxlA-3lzdA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ojl CAP5O

(Staphylococcus
aureus) 		PF00984
(UDPG_MGDP_dh)
PF03720
(UDPG_MGDP_dh_C)
PF03721
(UDPG_MGDP_dh_N) 		5 GLY A  12
SER A  73
LYS A   2
VAL A  29
ASP A  30
 None
None
None
None
NAD  A 500 (-2.7A)
 1.50A 6bxlA-3ojlA:
2.8		 6bxlA-3ojlA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pm9 PUTATIVE
OXIDOREDUCTASE

(Rhodopseudomonas
palustris) 		PF01565
(FAD_binding_4)
PF02913
(FAD-oxidase_C) 		5 GLY A 386
HIS A 387
SER A 398
GLN A 344
ASP A 354
 None
UNL  A 477 ( 3.7A)
None
PO4  A 490 (-2.9A)
None
 1.49A 6bxlA-3pm9A:
undetectable		 6bxlA-3pm9A:
22.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpy ALGINATE LYASE,
FAMILY PL7

(Zobellia
galactanivorans) 		PF08787
(Alginate_lyase2) 		5 TYR A 420
LEU A 306
GLY A 315
GLN A 341
ASP A 336
 None
 1.23A 6bxlA-3zpyA:
undetectable		 6bxlA-3zpyA:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr4 26S PROTEASE
REGULATORY SUBUNIT 7
HOMOLOG

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		5 GLY H 253
GLN H 217
CYH H 259
VAL H 211
ASP H 210
 None
 1.44A 6bxlA-4cr4H:
undetectable		 6bxlA-4cr4H:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crm TRANSLATION
INITIATION FACTOR
RLI1

(Saccharomyces
cerevisiae) 		PF00005
(ABC_tran)
PF00037
(Fer4)
PF04068
(RLI) 		5 LEU P 108
GLY P 107
ASP P 527
VAL P 283
ASP P 285
 None
 1.17A 6bxlA-4crmP:
undetectable		 6bxlA-4crmP:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		5 TYR A 981
LEU A 940
GLY A 941
SER A 998
ASP A 979
 None
 1.43A 6bxlA-4hviA:
undetectable		 6bxlA-4hviA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l37 ARYLPHORIN

(Bombyx mori) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		5 TYR B 189
LEU B 172
GLY B 171
SER B 466
ASP B 462
 None
 1.43A 6bxlA-4l37B:
undetectable		 6bxlA-4l37B:
19.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pxd ALLANTOATE
AMIDOHYDROLASE

(Escherichia
coli) 		PF01546
(Peptidase_M20) 		5 GLY A  93
HIS A 190
GLN A  40
ASP A  57
VAL A 121
 None
1AL  A 502 (-4.3A)
None
None
None
 1.39A 6bxlA-4pxdA:
undetectable		 6bxlA-4pxdA:
21.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r84 SIALYLTRANSFERASE
0160

(Photobacterium
damselae) 		PF11477
(PM0188) 		5 TYR A 448
LEU A 485
GLY A 486
VAL A 493
ASP A 492
 None
 1.21A 6bxlA-4r84A:
undetectable		 6bxlA-4r84A:
23.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ah0 LIPASE

(Pelosinus
fermentans) 		no annotation 5 LEU A  38
GLY A  43
SER A 129
ASP A 330
CYH A 376
 None
 1.49A 6bxlA-5ah0A:
undetectable		 6bxlA-5ah0A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5clw 1,4-ALPHA-GLUCAN-BRA
NCHING ENZYME

(Homo sapiens) 		PF00128
(Alpha-amylase)
PF02806
(Alpha-amylase_C)
PF02922
(CBM_48) 		5 HIS A 203
SER A 324
GLN A 252
VAL A 288
ASP A 286
 None
 1.25A 6bxlA-5clwA:
undetectable		 6bxlA-5clwA:
19.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dir LIPOPROTEIN SIGNAL
PEPTIDASE

(Pseudomonas
aeruginosa) 		PF01252
(Peptidase_A8) 		5 TYR A 114
LEU A 106
GLY A 107
VAL A  21
ASP A  23
 None
 1.31A 6bxlA-5dirA:
undetectable		 6bxlA-5dirA:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fzp DISPASE
AUTOLYSIS-INDUCING
PROTEIN

(Streptomyces
mobaraensis) 		no annotation 5 TYR A 146
LEU A 179
GLY A 127
ASP A 142
VAL A 124
 None
 1.26A 6bxlA-5fzpA:
undetectable		 6bxlA-5fzpA:
20.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5isu LMO0135 PROTEIN

(Listeria
monocytogenes) 		PF00496
(SBP_bac_5) 		5 TYR A 334
LEU A 454
SER A 326
GLN A 475
ASP A 429
 None
 1.38A 6bxlA-5isuA:
undetectable		 6bxlA-5isuA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jm6 AMINOPEPTIDASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF02127
(Peptidase_M18) 		5 TYR A 161
LEU A 282
GLY A 177
ASP A 338
VAL A  68
 None
 1.45A 6bxlA-5jm6A:
undetectable		 6bxlA-5jm6A:
22.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kxi NEURONAL
ACETYLCHOLINE
RECEPTOR SUBUNIT
ALPHA-4

(Homo sapiens) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		5 TYR A 192
LEU A  42
GLY A  41
SER A 155
VAL A  38
 None
 1.49A 6bxlA-5kxiA:
undetectable		 6bxlA-5kxiA:
18.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		5 GLY A 485
HIS A 487
LYS A 498
ASP A 708
CYH A 482
 None
 1.25A 6bxlA-5l46A:
3.5		 6bxlA-5l46A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l46 DIMETHYLGLYCINE
DEHYDROGENASE,
MITOCHONDRIAL

(Homo sapiens) 		PF01266
(DAO)
PF01571
(GCV_T)
PF08669
(GCV_T_C)
PF16350
(FAO_M) 		5 HIS A 487
LYS A 498
ASP A 708
CYH A 482
ASP A 533
 None
 1.35A 6bxlA-5l46A:
3.5		 6bxlA-5l46A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mkk MULTIDRUG RESISTANCE
ABC TRANSPORTER
ATP-BINDING AND
PERMEASE PROTEIN

(Thermus
thermophilus) 		PF00005
(ABC_tran)
PF00664
(ABC_membrane) 		5 LEU A 504
GLY A 500
SER A 557
GLN A 537
ASP A 529
 None
 1.42A 6bxlA-5mkkA:
undetectable		 6bxlA-5mkkA:
21.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mr6 XIAF PROTEIN

(Streptomyces
sp.) 		PF08028
(Acyl-CoA_dh_2) 		5 TYR A 144
LEU A 149
GLY A 147
SER A 141
VAL A 122
 FAD  A 601 (-4.1A)
None
None
None
FAD  A 601 (-3.8A)
 1.43A 6bxlA-5mr6A:
undetectable		 6bxlA-5mr6A:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ngy DSR-M GLUCANSUCRASE
INACTIVE MUTANT
E715Q

(Leuconostoc
citreum) 		no annotation 5 GLY A1029
SER A 901
LYS A 921
GLN A 937
ASP A1032
 None
 1.37A 6bxlA-5ngyA:
undetectable		 6bxlA-5ngyA:
13.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v3s TWO-COMPONENT
INSECTICIDAL PROTEIN
16 KDA UNIT

(Alcaligenes
faecalis) 		PF06355
(Aegerolysin) 		5 LEU A  38
GLY A  85
GLN A  18
CYH A 103
ASP A 111
 None
 1.27A 6bxlA-5v3sA:
undetectable		 6bxlA-5v3sA:
17.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xj1 UNCHARACTERIZED RNA
METHYLTRANSFERASE
SP_1029

(Streptococcus
pneumoniae) 		no annotation 5 GLY A 261
SER A 205
GLN A 207
ASP A 273
ASP A 263
 None
 1.34A 6bxlA-5xj1A:
3.0		 6bxlA-5xj1A:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
US5

(Toxoplasma
gondii) 		PF00333
(Ribosomal_S5)
PF03719
(Ribosomal_S5_C) 		5 LEU C 196
GLY C 197
SER C 143
VAL C 112
ASP C  87
 None
 1.24A 6bxlA-5xxuC:
undetectable		 6bxlA-5xxuC:
19.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ykb TREHALOSE SYNTHASE

(Deinococcus
radiodurans) 		no annotation 5 LEU A  53
GLY A 100
SER A  59
ASP A  63
VAL A 103
 None
 1.25A 6bxlA-5ykbA:
undetectable		 6bxlA-5ykbA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yyl -

(-) 		no annotation 5 TYR A 276
LEU A 213
GLY A 212
SER A 306
ASP A 232
 None
 1.29A 6bxlA-5yylA:
undetectable		 6bxlA-5yylA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bxn DIPHTHAMIDE
BIOSYNTHESIS ENZYME
DPH2

(Candidatus
Methanoperedens
nitroreducens) 		no annotation 8 LEU A 157
GLY A 158
HIS A 180
SER A 232
LYS A 234
GLN A 237
CYH A 283
ASP A 289
 SAM  A 901 (-3.8A)
SF4  A 900 ( 3.6A)
SAM  A 901 (-4.2A)
SAM  A 901 ( 3.9A)
SAM  A 901 (-4.9A)
SAM  A 901 (-3.0A)
SF4  A 900 ( 2.2A)
SAM  A 901 (-3.9A)
 0.53A 6bxlA-6bxnA:
19.3		 6bxlA-6bxnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dgc ISC1926 TNPA
C-TERMINAL CATALYTIC
DOMAIN

(Sulfolobus sp.
L00 11) 		no annotation 5 LEU A 111
GLY A 110
ASP A  77
VAL A  73
ASP A 106
 None
 1.21A 6bxlA-6dgcA:
3.1		 6bxlA-6dgcA:
undetectable