SIMILAR PATTERNS OF AMINO ACIDS FOR 6BTX_A_EDTA503_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cjy PROTEIN (CYTOSOLIC
PHOSPHOLIPASE A2)

(Homo sapiens) 		PF00168
(C2)
PF01735
(PLA2_B) 		4 TRP A 393
SER A 550
GLY A 196
LEU A 560
 None
 0.98A 6btxA-1cjyA:
0.0		 6btxA-1cjyA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ems NIT-FRAGILE
HISTIDINE TRIAD
FUSION PROTEIN

(Caenorhabditis
elegans) 		PF00795
(CN_hydrolase)
PF01230
(HIT) 		4 SER A  93
HIS A 112
GLY A  95
LEU A 164
 None
 1.02A 6btxA-1emsA:
0.0		 6btxA-1emsA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1imv PIGMENT
EPITHELIUM-DERIVED
FACTOR

(Homo sapiens) 		PF00079
(Serpin) 		4 SER A  61
SER A  64
GLY A 189
LEU A 116
 None
 1.14A 6btxA-1imvA:
0.0		 6btxA-1imvA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1itu RENAL DIPEPTIDASE

(Homo sapiens) 		PF01244
(Peptidase_M19) 		4 TRP A  25
SER A  66
HIS A 152
GLY A 126
 CIL  A 451 ( 4.4A)
ZN  A 401 ( 3.7A)
CIL  A 451 (-4.0A)
None
 1.03A 6btxA-1ituA:
undetectable		 6btxA-1ituA:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2q PROTEASOME ALPHA
SUBUNIT

(Archaeoglobus
fulgidus) 		PF00227
(Proteasome)
PF10584
(Proteasome_A_N) 		4 SER A 135
SER A  79
GLY A  34
LEU A 137
 None
 1.10A 6btxA-1j2qA:
0.0		 6btxA-1j2qA:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lml LEISHMANOLYSIN

(Leishmania
major) 		PF01457
(Peptidase_M8) 		4 SER A 418
SER A 421
GLY A 423
LEU A 257
 None
 1.15A 6btxA-1lmlA:
0.0		 6btxA-1lmlA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1m6s L-ALLO-THREONINE
ALDOLASE

(Thermotoga
maritima) 		PF01212
(Beta_elim_lyase) 		4 SER A 192
SER A  65
GLY A  61
LEU A 131
 None
 0.76A 6btxA-1m6sA:
0.0		 6btxA-1m6sA:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ml4 ASPARTATE
TRANSCARBAMOYLASE

(Pyrococcus
abyssi) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 SER A  55
HIS A 135
GLY A 129
ARG A 297
 PAL  A 385 (-2.6A)
PAL  A 385 (-3.9A)
None
None
 1.10A 6btxA-1ml4A:
0.0		 6btxA-1ml4A:
24.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ms8 TRANS-SIALIDASE

(Trypanosoma
cruzi) 		PF13385
(Laminin_G_3)
PF13859
(BNR_3) 		4 SER A 598
SER A 498
GLY A 496
LEU A 500
 None
 1.10A 6btxA-1ms8A:
undetectable		 6btxA-1ms8A:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nd1 BAP1

(Bothrops asper) 		PF01421
(Reprolysin) 		4 SER A 122
GLY A 115
ARG A  82
LEU A  87
 None
 1.11A 6btxA-1nd1A:
0.3		 6btxA-1nd1A:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pg5 ASPARTATE
CARBAMOYLTRANSFERASE

(Sulfolobus
acidocaldarius) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 SER A  49
HIS A 129
GLY A 123
ARG A 289
 None
 1.10A 6btxA-1pg5A:
undetectable		 6btxA-1pg5A:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q1l CHORISMATE SYNTHASE

(Aquifex
aeolicus) 		PF01264
(Chorismate_synt) 		4 SER A 357
SER A 162
HIS A 191
GLY A 161
 None
 0.94A 6btxA-1q1lA:
undetectable		 6btxA-1q1lA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qax PROTEIN
(3-HYDROXY-3-METHYLG
LUTARYL-COENZYME A
REDUCTASE)

(Pseudomonas
mevalonii) 		PF00368
(HMG-CoA_red) 		4 TRP A 307
SER A 303
GLY A 268
ARG A 261
 None
None
HMG  A1002 (-3.5A)
HMG  A1002 (-3.0A)
 1.07A 6btxA-1qaxA:
undetectable		 6btxA-1qaxA:
24.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qgr PROTEIN (IMPORTIN
BETA SUBUNIT)

(Homo sapiens) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		4 HIS A 803
GLY A 806
ARG A 762
LEU A 758
 None
 1.03A 6btxA-1qgrA:
0.7		 6btxA-1qgrA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t61 TYPE IV COLLAGEN

(Bos taurus) 		PF01413
(C4) 		4 SER A 154
HIS A 146
GLY A 153
LEU A  47
 None
 1.11A 6btxA-1t61A:
undetectable		 6btxA-1t61A:
19.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlv ORNITHINE
CARBAMOYLTRANSFERASE

(Thermotoga
maritima) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 SER A  57
HIS A 135
GLY A 129
ARG A 300
 PO4  A 314 (-2.7A)
PO4  A 314 (-4.1A)
None
PO4  A 314 (-3.2A)
 1.11A 6btxA-1vlvA:
undetectable		 6btxA-1vlvA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w5d PENICILLIN-BINDING
PROTEIN

(Bacillus
subtilis) 		PF02113
(Peptidase_S13) 		4 SER A  53
SER A 422
GLY A 423
LEU A 438
 None
 1.10A 6btxA-1w5dA:
undetectable		 6btxA-1w5dA:
23.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z8w PYRROLIDONE-CARBOXYL
ATE PEPTIDASE

(Pyrococcus
furiosus) 		PF01470
(Peptidase_C15) 		4 SER A 162
HIS A  66
GLY A 163
LEU A  56
 None
 1.09A 6btxA-1z8wA:
undetectable		 6btxA-1z8wA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2be7 ASPARTATE
CARBAMOYLTRANSFERASE
CATALYTIC CHAIN

(Moritella
profunda) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 SER A  59
HIS A 134
GLY A 127
LEU A 140
 None
 0.92A 6btxA-2be7A:
undetectable		 6btxA-2be7A:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4n PROTEIN NAGD

(Escherichia
coli) 		PF13242
(Hydrolase_like)
PF13344
(Hydrolase_6) 		4 SER A 243
SER A 222
HIS A  16
GLY A  12
 None
None
None
MG  A1251 ( 4.6A)
 1.13A 6btxA-2c4nA:
undetectable		 6btxA-2c4nA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dct HYPOTHETICAL PROTEIN
TTHA0104

(Thermus
thermophilus) 		PF07883
(Cupin_2) 		4 SER A  49
HIS A  46
GLY A  48
LEU A  29
 None
 1.10A 6btxA-2dctA:
undetectable		 6btxA-2dctA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2erq VASCULAR
APOPTOSIS-INDUCING
PROTEIN 1

(Crotalus atrox) 		PF00200
(Disintegrin)
PF01421
(Reprolysin)
PF08516
(ADAM_CR) 		4 SER A 315
GLY A 308
ARG A 275
LEU A 280
 None
 1.14A 6btxA-2erqA:
undetectable		 6btxA-2erqA:
23.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gt1 LIPOPOLYSACCHARIDE
HEPTOSYLTRANSFERASE-
1

(Escherichia
coli) 		PF01075
(Glyco_transf_9) 		4 SER A 259
SER A 265
HIS A 266
GLY A 263
 None
 1.05A 6btxA-2gt1A:
undetectable		 6btxA-2gt1A:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gy7 ANGIOPOIETIN-2

(Homo sapiens) 		PF00147
(Fibrinogen_C) 		4 SER A 415
SER A 385
GLY A 408
LEU A 375
 None
 1.07A 6btxA-2gy7A:
undetectable		 6btxA-2gy7A:
18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iou MAJOR TROPISM
DETERMINANT P1

(Bordetella
virus BPP1) 		no annotation 4 TRP A 345
SER A 270
SER A 351
GLY A 342
 None
 0.92A 6btxA-2iouA:
undetectable		 6btxA-2iouA:
23.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iuw ALKYLATED REPAIR
PROTEIN ALKB HOMOLOG
3

(Homo sapiens) 		PF13532
(2OG-FeII_Oxy_2) 		4 SER A 206
SER A 208
GLY A 242
ARG A 269
 AKG  A 700 ( 4.1A)
AKG  A 700 ( 4.8A)
None
AKG  A 700 (-2.9A)
 1.05A 6btxA-2iuwA:
undetectable		 6btxA-2iuwA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qna IMPORTIN SUBUNIT
BETA-1

(Homo sapiens) 		PF13513
(HEAT_EZ) 		4 HIS A 803
GLY A 806
ARG A 762
LEU A 758
 None
 1.07A 6btxA-2qnaA:
1.1		 6btxA-2qnaA:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4j AEROBIC
GLYCEROL-3-PHOSPHATE
DEHYDROGENASE

(Escherichia
coli) 		PF01266
(DAO)
PF16901
(DAO_C) 		4 HIS A  80
GLY A 422
ARG A 150
LEU A 153
 None
 1.05A 6btxA-2r4jA:
undetectable		 6btxA-2r4jA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y24 XYLANASE

(Dickeya
chrysanthemi) 		PF02055
(Glyco_hydro_30)
PF17189
(Glyco_hydro_30C) 		4 SER A 161
HIS A 230
GLY A 229
ARG A  81
 None
None
None
XYP  A1001 ( 4.9A)
 1.03A 6btxA-2y24A:
undetectable		 6btxA-2y24A:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a0g HEMOGLOBIN SUBUNIT
BETA

(Cavia porcellus) 		PF00042
(Globin) 		4 SER B  70
HIS B  63
GLY B  64
LEU B  88
 HEM  B 401 ( 3.8A)
OXY  B 501 ( 4.1A)
None
HEM  B 401 ( 4.7A)
 1.12A 6btxA-3a0gB:
undetectable		 6btxA-3a0gB:
17.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a18 ALDOXIME DEHYDRATASE

(Rhodococcus
erythropolis) 		PF13816
(Dehydratase_hem) 		4 SER A 174
GLY A 173
ARG A 178
LEU A 145
 HEM  A 354 (-2.9A)
HEM  A 354 (-3.7A)
HEM  A 354 ( 4.2A)
BXO  A 355 ( 4.7A)
 1.04A 6btxA-3a18A:
undetectable		 6btxA-3a18A:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bi3 ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB

(Escherichia
coli) 		PF13532
(2OG-FeII_Oxy_2) 		4 SER A 145
SER A 147
GLY A 173
ARG A 204
 AKG  A 302 ( 3.8A)
AKG  A 302 ( 4.7A)
None
AKG  A 302 (-2.8A)
 0.97A 6btxA-3bi3A:
undetectable		 6btxA-3bi3A:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3btz ALPHA-KETOGLUTARATE-
DEPENDENT
DIOXYGENASE ALKB
HOMOLOG 2

(Homo sapiens) 		PF13532
(2OG-FeII_Oxy_2) 		4 SER A 186
SER A 188
GLY A 221
ARG A 248
 None
 0.90A 6btxA-3btzA:
undetectable		 6btxA-3btzA:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3j ENHANCER OF
MRNA-DECAPPING
PROTEIN 3

(Homo sapiens) 		PF03853
(YjeF_N)
PF09532
(FDF) 		4 SER A 352
HIS A 356
GLY A 309
ARG A 355
 None
 1.12A 6btxA-3d3jA:
undetectable		 6btxA-3d3jA:
22.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d3k ENHANCER OF
MRNA-DECAPPING
PROTEIN 3

(Homo sapiens) 		PF03853
(YjeF_N) 		4 SER A 352
HIS A 356
GLY A 309
LEU A 384
 None
 0.72A 6btxA-3d3kA:
undetectable		 6btxA-3d3kA:
20.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6n ASPARTATE
CARBAMOYLTRANSFERASE

(Aquifex
aeolicus) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 SER B  45
HIS B 126
GLY B 120
ARG B 282
 FLC  B 292 ( 4.5A)
FLC  B 292 (-4.0A)
None
None
 1.04A 6btxA-3d6nB:
undetectable		 6btxA-3d6nB:
22.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efm FERRIC ALCALIGIN
SIDEROPHORE RECEPTOR

(Bordetella
pertussis) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		4 SER A 318
SER A 316
HIS A 314
GLY A 333
 None
 1.11A 6btxA-3efmA:
undetectable		 6btxA-3efmA:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f0n MEVALONATE
PYROPHOSPHATE
DECARBOXYLASE

(Mus musculus) 		PF00288
(GHMP_kinases_N) 		4 SER A 127
SER A 156
GLY A 157
ARG A  78
 None
PO4  A 401 (-2.5A)
PO4  A 401 (-3.6A)
PO4  A 401 (-2.9A)
 1.01A 6btxA-3f0nA:
undetectable		 6btxA-3f0nA:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gbo ZINC
METALLOPROTEINASE
BMOOMPALFA-I

(Bothrops
moojeni) 		PF01421
(Reprolysin) 		4 SER A 120
GLY A 113
ARG A  80
LEU A  85
 None
 1.04A 6btxA-3gboA:
undetectable		 6btxA-3gboA:
19.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ipl 2-SUCCINYLBENZOATE--
COA LIGASE

(Staphylococcus
aureus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 SER A 310
SER A 218
GLY A 216
ARG A 222
 None
 1.12A 6btxA-3iplA:
undetectable		 6btxA-3iplA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4r UNCHARACTERIZED
PROTEIN

(Thermoplasma
acidophilum) 		PF00596
(Aldolase_II) 		4 SER A 111
HIS A 129
GLY A  35
LEU A 116
 None
ZN  A 220 (-3.3A)
None
None
 0.81A 6btxA-3m4rA:
undetectable		 6btxA-3m4rA:
20.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n5m ADENOSYLMETHIONINE-8
-AMINO-7-OXONONANOAT
E AMINOTRANSFERASE

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		4 SER A  60
SER A 285
GLY A 282
LEU A  67
 None
 1.09A 6btxA-3n5mA:
undetectable		 6btxA-3n5mA:
19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rwk INULINASE

(Aspergillus
ficuum) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 SER X 321
HIS X 447
GLY X 294
ARG X 431
 MAN  X 519 (-4.9A)
None
None
None
 0.90A 6btxA-3rwkX:
undetectable		 6btxA-3rwkX:
24.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s2j DIPEPTIDASE

(Streptomyces
coelicolor) 		PF01244
(Peptidase_M19) 		4 TRP A  25
SER A  66
HIS A 150
GLY A 124
 L3A  A 401 (-4.4A)
ZN  A 402 ( 3.9A)
EDO  A 409 ( 3.7A)
None
 1.06A 6btxA-3s2jA:
undetectable		 6btxA-3s2jA:
24.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3txx PUTRESCINE
CARBAMOYLTRANSFERASE

(Enterococcus
faecalis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 SER A  52
HIS A 130
GLY A 124
ARG A 297
 SO4  A 340 (-3.0A)
None
None
None
 1.15A 6btxA-3txxA:
1.2		 6btxA-3txxA:
22.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v10 RHUSIOPATHIAE
SURFACE PROTEIN B

(Erysipelothrix
rhusiopathiae) 		PF05737
(Collagen_bind) 		4 SER A  91
SER A 124
HIS A 125
GLY A 123
 None
 1.15A 6btxA-3v10A:
undetectable		 6btxA-3v10A:
19.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3va8 PROBABLE DEHYDRATASE

(Fusarium
graminearum) 		PF13378
(MR_MLE_C) 		4 SER A 291
SER A 302
GLY A 298
LEU A 341
 None
 1.14A 6btxA-3va8A:
undetectable		 6btxA-3va8A:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vsc PROTEIN CYSO

(Aeropyrum
pernix) 		PF00291
(PALP) 		4 SER A 341
SER A 259
HIS A 265
GLY A 258
 PLP  A 401 (-2.6A)
PLP  A 401 (-3.4A)
PLP  A 401 (-3.9A)
None
 1.08A 6btxA-3vscA:
undetectable		 6btxA-3vscA:
23.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w08 ALDOXIME DEHYDRATASE

(Pseudomonas
chlororaphis) 		PF13816
(Dehydratase_hem) 		4 SER A 174
GLY A 173
ARG A 178
LEU A 145
 HEM  A 501 (-3.1A)
HEM  A 501 (-3.7A)
HEM  A 501 ( 4.3A)
None
 1.05A 6btxA-3w08A:
undetectable		 6btxA-3w08A:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wd8 TYPE III POLYKETIDE
SYNTHASE QUINOLONE
SYNTHASE

(Citrus x
microcarpa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		4 SER A 341
HIS A 303
GLY A 339
LEU A 331
 None
 0.91A 6btxA-3wd8A:
undetectable		 6btxA-3wd8A:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a29 ENGINEERED
RETRO-ALDOL ENZYME
RA95.0

(synthetic
construct) 		PF00218
(IGPS) 		4 SER A  56
SER A 234
GLY A 212
ARG A 238
 MLT  A 300 (-3.8A)
MLT  A 300 (-3.0A)
MLT  A 300 (-2.8A)
None
 1.15A 6btxA-4a29A:
undetectable		 6btxA-4a29A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b0t PUP--PROTEIN LIGASE

(Corynebacterium
glutamicum) 		PF03136
(Pup_ligase) 		4 SER A 270
HIS A 165
GLY A 179
ARG A 163
 None
 1.04A 6btxA-4b0tA:
undetectable		 6btxA-4b0tA:
23.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7v TRANSKETOLASE

(Lactobacillus
salivarius) 		PF00456
(Transketolase_N)
PF02779
(Transket_pyr)
PF02780
(Transketolase_C) 		4 SER A 463
SER A 560
GLY A 559
LEU A 646
 None
 1.11A 6btxA-4c7vA:
undetectable		 6btxA-4c7vA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dyo ASPARTYL
AMINOPEPTIDASE

(Homo sapiens) 		PF02127
(Peptidase_M18) 		4 SER A 268
SER A 434
GLY A 450
LEU A 432
 None
 1.09A 6btxA-4dyoA:
undetectable		 6btxA-4dyoA:
23.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f0a PROTEIN WNT-8

(Xenopus laevis) 		PF00110
(wnt) 		4 SER B 244
HIS B 164
GLY B 247
LEU B 219
 None
 1.13A 6btxA-4f0aB:
1.8		 6btxA-4f0aB:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f2g ORNITHINE
CARBAMOYLTRANSFERASE
1

(Burkholderia
thailandensis) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 SER A  56
HIS A 134
GLY A 128
ARG A 292
 PO4  A 402 (-2.7A)
PO4  A 402 (-4.0A)
None
PO4  A 402 (-3.0A)
 1.15A 6btxA-4f2gA:
undetectable		 6btxA-4f2gA:
20.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3f SERINE HYDROLASE
CCSP0084

(Cycloclasticus
sp. P1) 		PF12697
(Abhydrolase_6) 		4 SER A  32
SER A 104
GLY A 107
LEU A 140
 CL  A 302 (-3.1A)
CL  A 302 (-3.0A)
None
None
 0.94A 6btxA-4i3fA:
undetectable		 6btxA-4i3fA:
23.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i9a QUINOLINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Sus scrofa) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		4 SER A 268
HIS A 160
GLY A 136
LEU A 220
 NCN  A 301 (-3.4A)
NCN  A 301 (-3.5A)
None
None
 1.08A 6btxA-4i9aA:
undetectable		 6btxA-4i9aA:
21.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iug BETA-GALACTOSIDASE A

(Aspergillus
oryzae) 		PF01301
(Glyco_hydro_35)
PF10435
(BetaGal_dom2)
PF13363
(BetaGal_dom3)
PF13364
(BetaGal_dom4_5) 		4 TRP A  48
SER A 295
GLY A 256
LEU A  53
 None
 1.14A 6btxA-4iugA:
undetectable		 6btxA-4iugA:
20.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv5 ASPARTATE
CARBAMOYLTRANSFERASE
, PUTATIVE

(Trypanosoma
cruzi) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 SER A  62
HIS A 141
GLY A 135
ARG A 318
 PO4  A 401 (-2.6A)
UNX  A 402 ( 4.2A)
None
None
 1.06A 6btxA-4iv5A:
undetectable		 6btxA-4iv5A:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4iv6 ACYL-COA
DEHYDROGENASE FADE3

(Mycolicibacterium
smegmatis) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		4 SER A 155
GLY A  87
ARG A 248
LEU A 357
 FDA  A 401 (-2.9A)
None
None
FDA  A 401 (-4.9A)
 0.91A 6btxA-4iv6A:
1.1		 6btxA-4iv6A:
24.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j4m ZINC-DEPENDENT
METALLOPROTEINASE

(Protobothrops
mucrosquamatus) 		PF01421
(Reprolysin) 		4 SER A 124
GLY A 117
ARG A  84
LEU A  89
 None
 1.14A 6btxA-4j4mA:
undetectable		 6btxA-4j4mA:
18.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kxb GLUTAMYL
AMINOPEPTIDASE

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		4 SER A 230
HIS A 222
GLY A 202
LEU A 104
 None
 1.12A 6btxA-4kxbA:
1.5		 6btxA-4kxbA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7e PROTEIN
BRASSINOSTEROID
INSENSITIVE 1

(Arabidopsis
thaliana) 		PF00560
(LRR_1)
PF08263
(LRRNT_2)
PF12799
(LRR_4)
PF13516
(LRR_6)
PF13855
(LRR_8) 		4 SER A 734
SER A 711
HIS A 687
GLY A 686
 None
 0.96A 6btxA-4m7eA:
undetectable		 6btxA-4m7eA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m7g TRYPSIN-LIKE
PROTEASE

(Saccharopolyspora
erythraea) 		PF00089
(Trypsin) 		4 SER A  69
SER A  56
GLY A  66
LEU A  31
 None
 1.06A 6btxA-4m7gA:
undetectable		 6btxA-4m7gA:
18.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4npl RNA DEMETHYLASE
ALKBH5

(Danio rerio) 		PF13532
(2OG-FeII_Oxy_2) 		4 SER A 148
SER A 150
GLY A 182
ARG A 208
 AKG  A 301 ( 4.6A)
AKG  A 301 ( 4.8A)
None
AKG  A 301 (-3.0A)
 0.99A 6btxA-4nplA:
undetectable		 6btxA-4nplA:
20.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nrq RNA DEMETHYLASE
ALKBH5

(Homo sapiens) 		PF13532
(2OG-FeII_Oxy_2) 		4 SER A 217
SER A 219
GLY A 251
ARG A 277
 PD2  A 301 ( 4.9A)
PD2  A 301 ( 4.5A)
None
PD2  A 301 (-2.7A)
 1.08A 6btxA-4nrqA:
undetectable		 6btxA-4nrqA:
19.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pdh TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Polaromonas sp.
JS666) 		PF03480
(DctP) 		4 SER A 237
HIS A 241
GLY A 240
LEU A 173
 None
 1.11A 6btxA-4pdhA:
undetectable		 6btxA-4pdhA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1l SNAKE VENOM
METALLOPROTEINASE
LEUCUROLYSIN-A

(Bothrops
leucurus) 		PF01421
(Reprolysin) 		4 SER A 122
GLY A 115
ARG A  82
LEU A  87
 EDO  A 304 ( 4.7A)
None
EDO  A 304 (-2.6A)
None
 1.10A 6btxA-4q1lA:
undetectable		 6btxA-4q1lA:
17.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q9a TAT PATHWAY SIGNAL
SEQUENCE DOMAIN
PROTEIN

(Parabacteroides
merdae) 		PF13472
(Lipase_GDSL_2) 		4 SER A  76
GLY A  60
ARG A 242
LEU A 239
 None
 1.13A 6btxA-4q9aA:
undetectable		 6btxA-4q9aA:
18.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlq BENZOATE-COENZYME A
LIGASE

(Rhodopseudomonas
palustris) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 SER A 337
HIS A 333
GLY A 327
LEU A 210
 None
3SK  A1000 ( 4.1A)
3SK  A1000 (-3.6A)
None
 1.14A 6btxA-4rlqA:
undetectable		 6btxA-4rlqA:
24.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt6 HEME/HEMOPEXIN-BINDI
NG PROTEIN

(Haemophilus
influenzae) 		PF05860
(Haemagg_act) 		4 SER A 410
SER A 385
GLY A 388
LEU A 362
 None
 0.94A 6btxA-4rt6A:
undetectable		 6btxA-4rt6A:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tma DNA GYRASE SUBUNIT B

(Escherichia
coli) 		PF00986
(DNA_gyraseB_C)
PF01751
(Toprim) 		4 SER B 504
HIS B 505
GLY B 503
LEU B 776
 None
 1.12A 6btxA-4tmaB:
undetectable		 6btxA-4tmaB:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uta BROADLY NEUTRALIZING
HUMAN ANTIBODY EDE1
C8 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 SER H 101
SER H  33
HIS H  35
GLY H  98
 None
 0.86A 6btxA-4utaH:
undetectable		 6btxA-4utaH:
21.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4v2i ESTERASE/LIPASE

(Thalassospira
sp. GB04J01) 		PF07859
(Abhydrolase_3) 		4 TRP A 216
SER A 158
GLY A 160
LEU A 257
 None
 1.03A 6btxA-4v2iA:
undetectable		 6btxA-4v2iA:
22.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x04 SOLUTE BINDING
PROTEIN

(Citrobacter
koseri) 		PF03480
(DctP) 		4 SER A 233
HIS A 235
GLY A 234
LEU A 167
 None
 1.05A 6btxA-4x04A:
undetectable		 6btxA-4x04A:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ajz 6-PHOSPHOFRUCTO-2-KI
NASE/FRUCTOSE-2,6-BI
SPHOSPHATASE 3

(Homo sapiens) 		PF00300
(His_Phos_1)
PF01591
(6PF2K) 		4 SER A 437
HIS A 253
GLY A 254
ARG A 252
 None
PHS  A1446 (-3.4A)
None
PHS  A1446 (-3.5A)
 1.16A 6btxA-5ajzA:
undetectable		 6btxA-5ajzA:
20.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ayn SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER)

(Bdellovibrio
bacteriovorus) 		PF06963
(FPN1) 		6 SER A 256
SER A 259
HIS A 261
GLY A 262
ARG A 348
LEU A 351
 None
 0.93A 6btxA-5aynA:
32.1		 6btxA-5aynA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ayn SOLUTE CARRIER
FAMILY 39
(IRON-REGULATED
TRANSPORTER)

(Bdellovibrio
bacteriovorus) 		PF06963
(FPN1) 		5 TRP A 254
SER A 259
HIS A 261
ARG A 348
LEU A 351
 None
 1.04A 6btxA-5aynA:
32.1		 6btxA-5aynA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cxp POSSIBLE XYLAN
DEGRADATION ENZYME
(GLYCOSYL HYDROLASE
FAMILY 30-LIKE
DOMAIN AND RICIN
B-LIKE DOMAIN)

(Clostridium
acetobutylicum) 		PF02055
(Glyco_hydro_30) 		4 SER A 137
HIS A 207
GLY A 206
ARG A  48
 None
None
None
P6G  A 622 ( 4.8A)
 1.07A 6btxA-5cxpA:
undetectable		 6btxA-5cxpA:
23.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f4o CAPSID PROTEIN VP1

(Norwalk virus) 		PF08435
(Calici_coat_C) 		4 SER A 359
SER A 356
GLY A 329
ARG A 372
 None
 1.09A 6btxA-5f4oA:
undetectable		 6btxA-5f4oA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hd2 PARASPORAL CRYSTAL
PROTEIN

(Bacillus
thuringiensis) 		PF03318
(ETX_MTX2) 		4 SER A 109
SER A 142
GLY A 101
LEU A 112
 None
 1.11A 6btxA-5hd2A:
undetectable		 6btxA-5hd2A:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1

(Homo sapiens) 		PF03068
(PAD)
PF08526
(PAD_N)
PF08527
(PAD_M) 		4 TRP A 349
SER A 405
HIS A 472
GLY A 471
 None
 1.15A 6btxA-5hp5A:
undetectable		 6btxA-5hp5A:
23.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hy7 PUTATIVE PRE-MRNA
SPLICING PROTEIN

(Chaetomium
thermophilum) 		PF03178
(CPSF_A)
PF10433
(MMS1_N) 		4 SER A 657
SER A 608
GLY A 627
LEU A 711
 None
 1.06A 6btxA-5hy7A:
undetectable		 6btxA-5hy7A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iz5 CYTOSOLIC
PHOSPHOLIPASE A2
DELTA

(Homo sapiens) 		no annotation 4 TRP B 527
SER B 602
GLY B 503
ARG B 601
 None
SO4  B 909 (-2.2A)
None
SO4  B 909 (-3.8A)
 1.06A 6btxA-5iz5B:
undetectable		 6btxA-5iz5B:
21.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l25 BORON TRANSPORTER 1

(Arabidopsis
thaliana) 		PF00955
(HCO3_cotransp) 		4 SER A 354
HIS A  82
GLY A  79
LEU A 339
 None
 1.06A 6btxA-5l25A:
2.7		 6btxA-5l25A:
21.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lbs BROADLY NEUTRALIZING
HUMAN ANTIBODY EDE1
C8

(Homo sapiens) 		PF07686
(V-set) 		4 SER H  97
SER H  33
HIS H  35
GLY H  94
 None
 0.84A 6btxA-5lbsH:
undetectable		 6btxA-5lbsH:
16.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mln ALCOHOL
DEHYDROGENASE 3

([Candida]
magnoliae) 		no annotation 4 SER A  37
SER A  13
GLY A  12
ARG A  14
 NAP  A 301 (-2.8A)
NAP  A 301 (-2.7A)
NAP  A 301 ( 4.7A)
NAP  A 301 (-3.0A)
 1.00A 6btxA-5mlnA:
undetectable		 6btxA-5mlnA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nnn CTATC

(Chaetomium
thermophilum) 		PF00185
(OTCace)
PF02729
(OTCace_N) 		4 SER A2008
HIS A2081
GLY A2074
LEU A2087
 None
 0.94A 6btxA-5nnnA:
undetectable		 6btxA-5nnnA:
23.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5olt -

(-) 		no annotation 4 SER A 244
HIS A 443
GLY A 444
LEU A 393
 ZN  A 601 ( 4.4A)
ZN  A 601 (-3.2A)
None
None
 0.98A 6btxA-5oltA:
undetectable		 6btxA-5oltA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tgt GLUTAMATE--TRNA
LIGASE

(Pseudomonas
aeruginosa) 		PF00749
(tRNA-synt_1c) 		4 TRP A 341
GLY A 370
ARG A 466
LEU A 462
 None
 1.00A 6btxA-5tgtA:
undetectable		 6btxA-5tgtA:
21.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5viy BG1 FAB HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 SER H  23
SER H   7
GLY H   8
ARG H 125
 None
 1.12A 6btxA-5viyH:
undetectable		 6btxA-5viyH:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5voh NADH OXIDASE

(Lactobacillus
brevis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 SER A 111
SER A 280
GLY A 278
LEU A 249
 FAD  A 501 (-4.5A)
None
FAD  A 501 (-3.0A)
None
 1.14A 6btxA-5vohA:
undetectable		 6btxA-5vohA:
22.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vqd BETA-GLUCOSIDE
PHOSPHORYLASE BGLX

(unidentified) 		no annotation 4 SER A 512
SER A 112
GLY A 115
ARG A  95
 None
 1.10A 6btxA-5vqdA:
0.9		 6btxA-5vqdA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wgx FLAVIN-DEPENDENT
HALOGENASE

(Malbranchea
aurantiaca) 		PF04820
(Trp_halogenase) 		4 TRP A 265
SER A  82
SER A 409
GLY A 411
 None
CL  A 717 (-3.9A)
CL  A 717 ( 3.0A)
FAD  A 701 (-3.2A)
 0.94A 6btxA-5wgxA:
undetectable		 6btxA-5wgxA:
22.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wzk PUMILIO HOMOLOG 23

(Arabidopsis
thaliana) 		no annotation 4 SER A 222
HIS A 223
GLY A 221
ARG A 226
 None
G  B   9 ( 3.3A)
None
C  B   8 ( 3.0A)
 1.09A 6btxA-5wzkA:
undetectable		 6btxA-5wzkA:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xoi OXIDOREDUCTASE,
2OG-FE OXYGENASE
FAMILY PROTEIN,
PUTATIVE, EXPRESSED

(Oryza sativa) 		no annotation 4 SER A 297
SER A 299
GLY A 325
ARG A 363
 SIN  A 401 ( 4.1A)
None
None
SIN  A 401 (-2.8A)
 1.03A 6btxA-5xoiA:
undetectable		 6btxA-5xoiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ypt STILBENECARBOXYLATE
SYNTHASE 1

(Marchantia
polymorpha) 		no annotation 4 SER A 343
HIS A 305
GLY A 341
LEU A 333
 None
 0.85A 6btxA-5yptA:
undetectable		 6btxA-5yptA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bdz DISINTEGRIN AND
METALLOPROTEINASE
DOMAIN-CONTAINING
PROTEIN 10

(Homo sapiens) 		no annotation 4 SER A 436
SER A 391
HIS A 387
GLY A 386
 None
None
ZN  A 705 (-4.0A)
None
 1.15A 6btxA-6bdzA:
undetectable		 6btxA-6bdzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c4g ASPARTIC PROTEASE
PM5

(Plasmodium
vivax) 		no annotation 4 SER A  85
SER A  87
HIS A 173
GLY A 187
 EDO  A 506 ( 4.1A)
None
None
None
 1.09A 6btxA-6c4gA:
undetectable		 6btxA-6c4gA:
undetectable