SIMILAR PATTERNS OF AMINO ACIDS FOR 6BSG_A_EFZA601_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b04 PROTEIN (DNA LIGASE)

(Geobacillus
stearothermophilus) 		PF01653
(DNA_ligase_aden) 		5 LEU A 164
VAL A 220
TYR A 240
GLY A 222
TYR A 124
 None
 1.49A 6bsgA-1b04A:
undetectable		 6bsgA-1b04A:
11.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bmt METHIONINE SYNTHASE

(Escherichia
coli) 		PF02310
(B12-binding)
PF02607
(B12-binding_2) 		5 LEU A 831
VAL A 766
TYR A 775
GLY A 767
LEU A 800
 COB  A 122 (-4.4A)
COB  A 122 ( 4.6A)
None
None
None
 1.38A 6bsgA-1bmtA:
0.0		 6bsgA-1bmtA:
19.35
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1har HIV-1 REVERSE
TRANSCRIPTASE
(FINGERS AND PALM
SUBDOMAINS)

(Human
immunodeficiency
virus 1) 		PF00078
(RVT_1) 		5 LYS A 104
VAL A 179
TYR A 181
TYR A 188
GLY A 190
 None
 0.87A 6bsgA-1harA:
26.1		 6bsgA-1harA:
91.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i2l 4-AMINO-4-DEOXYCHORI
SMATE LYASE

(Escherichia
coli) 		PF01063
(Aminotran_4) 		5 LEU A 163
VAL A 244
VAL A 250
TRP A 181
LEU A 179
 None
 1.47A 6bsgA-1i2lA:
undetectable		 6bsgA-1i2lA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j2q PROTEASOME BETA
SUBUNIT

(Archaeoglobus
fulgidus) 		PF00227
(Proteasome) 		5 VAL H  49
VAL H  97
TYR H  95
GLY H  47
TYR H  35
 CIB  H1001 (-4.0A)
None
None
CIB  H1001 (-4.4A)
None
 1.44A 6bsgA-1j2qH:
undetectable		 6bsgA-1j2qH:
16.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7y METHIONINE SYNTHASE

(Escherichia
coli) 		PF02310
(B12-binding)
PF02607
(B12-binding_2)
PF02965
(Met_synt_B12) 		5 LEU A 831
VAL A 766
TYR A 775
GLY A 767
LEU A 800
 B12  A1248 (-4.3A)
B12  A1248 (-4.4A)
None
None
None
 1.35A 6bsgA-1k7yA:
1.4		 6bsgA-1k7yA:
10.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l6w FRUCTOSE-6-PHOSPHATE
ALDOLASE 1

(Escherichia
coli) 		PF00923
(TAL_FSA) 		5 LEU A  93
VAL A 128
VAL A  86
GLY A 108
LEU A 119
 None
 1.29A 6bsgA-1l6wA:
undetectable		 6bsgA-1l6wA:
17.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lfw PEPV

(Lactobacillus
delbrueckii) 		PF01546
(Peptidase_M20) 		5 LEU A 164
VAL A 173
TYR A 417
GLY A  83
LEU A 420
 None
 1.46A 6bsgA-1lfwA:
2.5		 6bsgA-1lfwA:
10.34
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1mu2 HIV-2 RT

(Human
immunodeficiency
virus 2) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		5 LEU A 100
LYS A 103
TRP A 229
LEU A 234
TYR A 318
 None
 1.04A 6bsgA-1mu2A:
29.6		 6bsgA-1mu2A:
63.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyp RIBONUCLEASE PH

(Bacillus
subtilis) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 201
 None
 1.48A 6bsgA-1oypA:
undetectable		 6bsgA-1oypA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oyp RIBONUCLEASE PH

(Bacillus
subtilis) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 219
 None
 1.14A 6bsgA-1oypA:
undetectable		 6bsgA-1oypA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qap QUINOLINIC ACID
PHOSPHORIBOSYLTRANSF
ERASE

(Salmonella
enterica) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		5 LEU A 148
VAL A 166
TYR A 137
GLY A 169
LEU A 141
 None
 1.44A 6bsgA-1qapA:
3.4		 6bsgA-1qapA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1udq RIBONUCLEASE PH

(Aquifex
aeolicus) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 LEU A 214
VAL A 164
VAL A 185
GLY A 165
LEU A 218
 None
 1.14A 6bsgA-1udqA:
undetectable		 6bsgA-1udqA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w78 FOLC BIFUNCTIONAL
PROTEIN

(Escherichia
coli) 		PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 VAL A 143
VAL A  95
TYR A  81
GLY A  79
LEU A 132
 None
 1.30A 6bsgA-1w78A:
undetectable		 6bsgA-1w78A:
12.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wdt ELONGATION FACTOR G
HOMOLOG

(Thermus
thermophilus) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		5 VAL A 503
VAL A 483
TYR A 508
TYR A 542
GLY A 540
 None
 1.43A 6bsgA-1wdtA:
4.2		 6bsgA-1wdtA:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yf2 TYPE I
RESTRICTION-MODIFICA
TION ENZYME, S
SUBUNIT

(Methanocaldococcus
jannaschii) 		PF01420
(Methylase_S) 		5 LEU A 368
VAL A 311
VAL A 308
GLY A 309
LEU A 327
 None
 1.23A 6bsgA-1yf2A:
undetectable		 6bsgA-1yf2A:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b4g DIHYDROOROTATE
DEHYDROGENASE

(Trypanosoma
brucei) 		PF01180
(DHO_dh) 		5 LEU A 231
VAL A 252
VAL A 226
GLY A 251
LEU A 260
 None
None
None
FMN  A1400 (-3.9A)
None
 1.34A 6bsgA-2b4gA:
undetectable		 6bsgA-2b4gA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4m GLYCOGEN
PHOSPHORYLASE

(Corynebacterium
callunae) 		PF00343
(Phosphorylase) 		5 LEU A 535
VAL A 688
TYR A 685
GLY A 690
LEU A 733
 None
 1.36A 6bsgA-2c4mA:
undetectable		 6bsgA-2c4mA:
7.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cf5 CINNAMYL ALCOHOL
DEHYDROGENASE

(Arabidopsis
thaliana) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 LEU A 189
VAL A 207
TYR A 229
GLY A 185
LEU A 224
 None
 1.48A 6bsgA-2cf5A:
undetectable		 6bsgA-2cf5A:
12.54
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		9 LEU A 100
LYS A 103
VAL A 106
VAL A 179
TYR A 181
GLY A 190
TRP A 229
LEU A 234
TYR A 318
 PC0  A 999 ( 3.9A)
None
PC0  A 999 ( 4.8A)
PC0  A 999 (-4.4A)
PC0  A 999 (-3.9A)
PC0  A 999 ( 4.8A)
PC0  A 999 ( 4.2A)
PC0  A 999 (-4.2A)
PC0  A 999 (-4.3A)
 0.81A 6bsgA-2hnzA:
35.8		 6bsgA-2hnzA:
98.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		9 LEU A 100
LYS A 103
VAL A 106
VAL A 179
TYR A 181
TYR A 188
GLY A 190
TRP A 229
TYR A 318
 PC0  A 999 ( 3.9A)
None
PC0  A 999 ( 4.8A)
PC0  A 999 (-4.4A)
PC0  A 999 (-3.9A)
PC0  A 999 (-4.1A)
PC0  A 999 ( 4.8A)
PC0  A 999 ( 4.2A)
PC0  A 999 (-4.3A)
 0.83A 6bsgA-2hnzA:
35.8		 6bsgA-2hnzA:
98.68
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2hnz REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H

(Human
immunodeficiency
virus 1) 		PF00075
(RNase_H)
PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		5 LEU A 100
LYS A 103
VAL A 179
TYR A 181
GLY A 190
 PC0  A 999 ( 3.9A)
None
PC0  A 999 (-4.4A)
PC0  A 999 (-3.9A)
PC0  A 999 ( 4.8A)
 1.46A 6bsgA-2hnzA:
35.8		 6bsgA-2hnzA:
98.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ix4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE

(Arabidopsis
thaliana) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 LEU A 130
VAL A 148
VAL A 230
GLY A 147
TYR A 196
 None
 1.26A 6bsgA-2ix4A:
undetectable		 6bsgA-2ix4A:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jbm NICOTINATE-NUCLEOTID
E PYROPHOSPHORYLASE

(Homo sapiens) 		PF01729
(QRPTase_C)
PF02749
(QRPTase_N) 		5 LEU A 110
VAL A 156
VAL A 149
TRP A  75
LEU A  56
 None
 1.32A 6bsgA-2jbmA:
4.0		 6bsgA-2jbmA:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6n ATP-DEPENDENT RNA
HELICASE DDX41

(Homo sapiens) 		PF00271
(Helicase_C) 		5 LEU A 545
VAL A 559
VAL A 412
TYR A 414
LEU A 566
 None
 1.27A 6bsgA-2p6nA:
undetectable		 6bsgA-2p6nA:
19.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjo BIFUNCTIONAL NMN
ADENYLYLTRANSFERASE/
NUDIX HYDROLASE

(Synechocystis
sp. PCC 6803) 		PF00293
(NUDIX)
PF01467
(CTP_transf_like) 		5 LEU A  27
VAL A  35
VAL A 107
TYR A  10
GLY A   8
 None
None
None
NAD  A 601 (-4.6A)
None
 1.10A 6bsgA-2qjoA:
undetectable		 6bsgA-2qjoA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vkp BTB/POZ
DOMAIN-CONTAINING
PROTEIN 6

(Homo sapiens) 		PF00651
(BTB) 		5 LEU A  66
VAL A  93
TYR A  91
GLY A  33
TYR A  70
 None
 1.17A 6bsgA-2vkpA:
undetectable		 6bsgA-2vkpA:
25.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wsm HYDROGENASE
EXPRESSION/FORMATION
PROTEIN (HYPB)

(Archaeoglobus
fulgidus) 		PF02492
(cobW) 		5 LEU A 113
VAL A  58
GLY A  55
TRP A 204
LEU A 208
 None
 1.48A 6bsgA-2wsmA:
undetectable		 6bsgA-2wsmA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yv4 HYPOTHETICAL PROTEIN
PH0435

(Pyrococcus
horikoshii) 		PF03481
(SUA5) 		5 LEU A 262
VAL A 271
VAL A 308
GLY A 270
LEU A 258
 None
 1.27A 6bsgA-2yv4A:
undetectable		 6bsgA-2yv4A:
26.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zns GLUTAMATE RECEPTOR,
IONOTROPIC KAINATE 1

(Homo sapiens) 		PF10613
(Lig_chan-Glu_bd) 		5 LEU A 452
VAL A 751
GLY A 750
LEU A 776
TYR A 448
 None
 1.11A 6bsgA-2znsA:
undetectable		 6bsgA-2znsA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3any ETHANOLAMINE
AMMONIA-LYASE HEAVY
CHAIN

(Escherichia
coli) 		PF06751
(EutB) 		5 LEU A 206
VAL A 189
VAL A 192
GLY A 191
TYR A 210
 None
 1.17A 6bsgA-3anyA:
undetectable		 6bsgA-3anyA:
9.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3aqu AT4G19810

(Arabidopsis
thaliana) 		PF00704
(Glyco_hydro_18) 		5 LEU A 130
VAL A  42
TYR A  82
TRP A 115
LEU A 113
 None
 1.41A 6bsgA-3aquA:
undetectable		 6bsgA-3aquA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b4t RIBONUCLEASE PH

(Mycobacterium
tuberculosis) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 LEU A 216
VAL A 166
VAL A 187
GLY A 167
LEU A 220
 None
 1.14A 6bsgA-3b4tA:
undetectable		 6bsgA-3b4tA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dd6 RIBONUCLEASE PH

(Bacillus
anthracis) 		PF01138
(RNase_PH)
PF03725
(RNase_PH_C) 		5 LEU A 215
VAL A 164
VAL A 186
GLY A 165
LEU A 219
 None
 1.15A 6bsgA-3dd6A:
undetectable		 6bsgA-3dd6A:
16.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3esr D,D-HEPTOSE
1,7-BISPHOSPHATE
PHOSPHATASE

(Escherichia
coli) 		PF13242
(Hydrolase_like) 		5 LEU A 199
TYR A 152
GLY A 155
TRP A 191
LEU A 193
 None
 1.45A 6bsgA-3esrA:
undetectable		 6bsgA-3esrA:
16.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ik2 ENDOGLUCANASE A

(Clostridium
acetobutylicum) 		PF12891
(Glyco_hydro_44) 		5 LEU A 371
VAL A 395
TYR A 355
GLY A 364
TYR A 402
 None
 1.41A 6bsgA-3ik2A:
undetectable		 6bsgA-3ik2A:
10.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l15 TRANSCRIPTIONAL
ENHANCER FACTOR
TEF-4

(Homo sapiens) 		no annotation 5 VAL A 252
VAL A 329
TYR A 327
TRP A 308
LEU A 306
 None
 1.49A 6bsgA-3l15A:
undetectable		 6bsgA-3l15A:
17.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l8e D,D-HEPTOSE
1,7-BISPHOSPHATE
PHOSPHATASE

(Escherichia
coli) 		PF13242
(Hydrolase_like) 		5 LEU A 179
TYR A 132
GLY A 135
TRP A 171
LEU A 173
 None
 1.47A 6bsgA-3l8eA:
undetectable		 6bsgA-3l8eA:
16.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nks PROTOPORPHYRINOGEN
OXIDASE

(Homo sapiens) 		PF01593
(Amino_oxidase) 		5 LEU A 401
VAL A 335
VAL A 367
GLY A 345
LEU A 105
 None
None
None
ACJ  A 478 (-3.6A)
None
 1.35A 6bsgA-3nksA:
undetectable		 6bsgA-3nksA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oaa ATP SYNTHASE SUBUNIT
BETA

(Escherichia
coli) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		5 LEU D 147
VAL D 157
VAL D 153
GLY D 154
LEU D 162
 None
ADP  D 600 (-4.0A)
ADP  D 600 (-4.6A)
ADP  D 600 (-3.0A)
None
 1.48A 6bsgA-3oaaD:
undetectable		 6bsgA-3oaaD:
10.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ta6 TRIOSEPHOSPHATE
ISOMERASE

(Mycobacterium
tuberculosis) 		PF00121
(TIM) 		5 LEU A 243
VAL A  43
VAL A 238
GLY A   9
LEU A  15
 None
 1.34A 6bsgA-3ta6A:
undetectable		 6bsgA-3ta6A:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tl8 EFFECTOR PROTEIN
HOPAB2

(Pseudomonas
syringae group
genomosp. 3) 		PF16847
(AvrPtoB_bdg) 		5 LEU B 344
VAL B 290
VAL B 324
GLY B 288
LEU B 348
 None
 1.42A 6bsgA-3tl8B:
undetectable		 6bsgA-3tl8B:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uit INAD-LIKE PROTEIN,
MAGUK P55 SUBFAMILY
MEMBER 5, PROTEIN
LIN-7 HOMOLOG B

(Homo sapiens;
Mus musculus;
Rattus
norvegicus) 		PF02828
(L27)
PF09045
(L27_2)
PF09060
(L27_N) 		5 LEU A 178
VAL A 185
VAL A 196
TYR A 253
GLY A 193
 None
 1.42A 6bsgA-3uitA:
undetectable		 6bsgA-3uitA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w4r CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18) 		5 LEU A 145
VAL A 128
VAL A 118
TYR A 114
LEU A 143
 None
 1.44A 6bsgA-3w4rA:
undetectable		 6bsgA-3w4rA:
10.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfz LACTO-N-BIOSE
PHOSPHORYLASE

(Bifidobacterium
longum) 		PF09508
(Lact_bio_phlase)
PF17385
(LBP_M)
PF17386
(LBP_C) 		5 LEU A 680
VAL A 665
VAL A 542
GLY A 541
LEU A 684
 None
 1.40A 6bsgA-3wfzA:
undetectable		 6bsgA-3wfzA:
7.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wl1 CHITINASE

(Ostrinia
furnacalis) 		PF00704
(Glyco_hydro_18) 		5 LEU A 145
VAL A 128
VAL A 118
TYR A 114
LEU A 143
 None
 1.43A 6bsgA-3wl1A:
undetectable		 6bsgA-3wl1A:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d4g APNAA1

(Planktothrix
agardhii) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 LEU A  71
VAL A  57
TYR A 151
GLY A  58
LEU A  75
 None
 1.39A 6bsgA-4d4gA:
undetectable		 6bsgA-4d4gA:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dlq LATROPHILIN-1

(Rattus
norvegicus) 		PF01825
(GPS)
PF02793
(HRM)
PF16489
(GAIN) 		5 LEU A 651
VAL A 679
VAL A 620
TRP A 636
LEU A 733
 None
 1.50A 6bsgA-4dlqA:
undetectable		 6bsgA-4dlqA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f92 U5 SMALL NUCLEAR
RIBONUCLEOPROTEIN
200 KDA HELICASE

(Homo sapiens) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		5 LEU B1597
VAL B1617
VAL B1632
GLY B1618
LEU B1590
 None
 1.42A 6bsgA-4f92B:
undetectable		 6bsgA-4f92B:
4.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jgg ESTERASE TESA

(Pseudomonas
aeruginosa) 		PF13472
(Lipase_GDSL_2) 		5 LEU A 176
VAL A  39
TYR A  35
TYR A  37
LEU A  67
 None
 1.27A 6bsgA-4jggA:
undetectable		 6bsgA-4jggA:
18.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m5p NADPH DEHYDROGENASE

(Scheffersomyces
stipitis) 		PF00724
(Oxidored_FMN) 		5 LEU A 165
VAL A 132
GLY A 116
LEU A 195
TYR A 170
 None
 1.40A 6bsgA-4m5pA:
undetectable		 6bsgA-4m5pA:
11.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pg6 HOMOSERINE
DEHYDROGENASE

(Staphylococcus
aureus) 		PF00742
(Homoserine_dh)
PF03447
(NAD_binding_3) 		5 LEU A   8
VAL A  14
VAL A 311
GLY A 307
LEU A  11
 None
ACT  A 503 ( 4.9A)
None
None
DMS  A 511 (-4.8A)
 1.50A 6bsgA-4pg6A:
undetectable		 6bsgA-4pg6A:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tpn PUTATIVE P450-LIKE
PROTEIN

(Streptomyces
scabiei) 		PF00067
(p450) 		5 LEU A 239
VAL A 211
VAL A 216
GLY A 156
LEU A 204
 None
 1.48A 6bsgA-4tpnA:
undetectable		 6bsgA-4tpnA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w7v CELLULASE

(Xanthomonas
citri) 		PF00150
(Cellulase) 		5 LEU A 263
VAL A   5
GLY A 275
TRP A 278
LEU A 308
 None
 1.03A 6bsgA-4w7vA:
undetectable		 6bsgA-4w7vA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wjs RSA4

(Chaetomium
thermophilum) 		PF00400
(WD40) 		5 LEU A 442
VAL A 449
GLY A 423
TRP A 454
LEU A 430
 None
 1.37A 6bsgA-4wjsA:
undetectable		 6bsgA-4wjsA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wsb POLYMERASE PB2

(Influenza A
virus) 		PF00604
(Flu_PB2) 		5 VAL C 672
GLY C 673
TRP C 557
LEU C 680
TYR C 658
 None
 1.16A 6bsgA-4wsbC:
undetectable		 6bsgA-4wsbC:
7.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xb0 SERINE/THREONINE-PRO
TEIN KINASE PLK2

(Homo sapiens) 		PF00659
(POLO_box) 		5 VAL A 527
VAL A 508
TYR A 510
TYR A 514
GLY A 517
 None
 1.42A 6bsgA-4xb0A:
undetectable		 6bsgA-4xb0A:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xii CHOLINESTERASE

(Homo sapiens) 		PF00135
(COesterase) 		5 LEU A 403
VAL A 319
VAL A 321
TYR A 500
GLY A 320
 None
 1.28A 6bsgA-4xiiA:
undetectable		 6bsgA-4xiiA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y9a TRIOSEPHOSPHATE
ISOMERASE

(Streptomyces
coelicolor) 		PF00121
(TIM) 		5 LEU A 247
VAL A  47
VAL A 242
GLY A  13
LEU A  19
 None
 1.29A 6bsgA-4y9aA:
undetectable		 6bsgA-4y9aA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yru NEURONAL CALCIUM
SENSOR 1

(Rattus
norvegicus) 		PF00036
(EF-hand_1)
PF13499
(EF-hand_7) 		5 LYS A 100
VAL A  91
GLY A  95
TRP A  30
LEU A  89
 None
 1.37A 6bsgA-4yruA:
undetectable		 6bsgA-4yruA:
21.59
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c24 HIV-1 REVERSE
TRANSCRIPTASE, P51
SUBUNIT

(Human
immunodeficiency
virus 1) 		PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		5 LYS B 103
VAL B 106
VAL B 179
TYR B 188
GLY B 190
 None
 1.06A 6bsgA-5c24B:
11.0		 6bsgA-5c24B:
98.67
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5c24 HIV-1 REVERSE
TRANSCRIPTASE, P51
SUBUNIT

(Human
immunodeficiency
virus 1) 		PF00078
(RVT_1)
PF06815
(RVT_connect)
PF06817
(RVT_thumb) 		5 LYS B 103
VAL B 179
TYR B 181
TYR B 188
GLY B 190
 None
 0.84A 6bsgA-5c24B:
11.0		 6bsgA-5c24B:
98.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e7p CELL DIVISION
CONTROL PROTEIN
CDC48

(Mycolicibacterium
smegmatis) 		PF00004
(AAA)
PF02359
(CDC48_N) 		5 LEU A 640
VAL A 522
TYR A 525
GLY A 627
LEU A 648
 None
 1.47A 6bsgA-5e7pA:
2.8		 6bsgA-5e7pA:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fg9 PROTEASOME SUBUNIT
BETA TYPE-2

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF12465
(Pr_beta_C) 		5 LEU H 154
VAL H  13
VAL H   4
GLY H   5
LEU H 146
 None
 1.48A 6bsgA-5fg9H:
undetectable		 6bsgA-5fg9H:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fg9 PROTEASOME SUBUNIT
BETA TYPE-2

(Saccharomyces
cerevisiae) 		PF00227
(Proteasome)
PF12465
(Pr_beta_C) 		5 LEU H 154
VAL H  13
VAL H   4
TYR H 124
LEU H 146
 None
 0.92A 6bsgA-5fg9H:
undetectable		 6bsgA-5fg9H:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fol LEUCYL-TRNA
SYNTHETASE

(Cryptosporidium
muris) 		no annotation 5 VAL A 362
TYR A 354
TYR A 358
GLY A 360
TYR A 539
 None
 1.50A 6bsgA-5folA:
undetectable		 6bsgA-5folA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5g51 DWV-VP3-P-DOMAIN

(Deformed wing
virus) 		no annotation 5 LEU A 364
VAL A 332
VAL A 286
GLY A 342
LEU A 358
 None
 1.34A 6bsgA-5g51A:
undetectable		 6bsgA-5g51A:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kuf GLUTAMATE RECEPTOR
IONOTROPIC, KAINATE
2

(Rattus
norvegicus) 		PF00060
(Lig_chan)
PF01094
(ANF_receptor)
PF10613
(Lig_chan-Glu_bd) 		5 LEU A 435
VAL A 735
GLY A 734
LEU A 760
TYR A 431
 None
 0.94A 6bsgA-5kufA:
undetectable		 6bsgA-5kufA:
6.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mg5 HYDROXYMETHYLGLUTARY
L-COA SYNTHASE

(Pseudomonas
protegens) 		no annotation 5 LEU A 288
VAL A 240
TYR A 238
GLY A 283
TYR A  11
 None
 1.36A 6bsgA-5mg5A:
undetectable		 6bsgA-5mg5A:
20.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ovn POL PROTEIN

(Feline
immunodeficiency
virus) 		no annotation 6 LEU A  99
LYS A 102
VAL A 105
GLY A 189
LEU A 233
TYR A 317
 None
 0.80A 6bsgA-5ovnA:
25.9		 6bsgA-5ovnA:
50.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ovn POL PROTEIN

(Feline
immunodeficiency
virus) 		no annotation 5 LYS B 102
VAL B 105
TYR B 180
TYR B 187
GLY B 189
 None
 0.93A 6bsgA-5ovnB:
10.5		 6bsgA-5ovnB:
57.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5sy1 STRA6

(Danio rerio) 		PF14752
(RBP_receptor) 		5 LEU A 196
VAL A  91
VAL A  96
GLY A  95
LEU A  89
 None
 1.19A 6bsgA-5sy1A:
undetectable		 6bsgA-5sy1A:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v41 POLYKETIDE SYNTHASE
PKS13 (TERMINATION
POLYKETIDE SYNTHASE)

(Mycobacterium
tuberculosis) 		PF00975
(Thioesterase) 		5 LEU A1518
VAL A1473
VAL A1456
GLY A1499
LEU A1529
 None
 1.23A 6bsgA-5v41A:
undetectable		 6bsgA-5v41A:
14.98