SIMILAR PATTERNS OF AMINO ACIDS FOR 6BSD_A_1N1A901_0

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k2p TYROSINE-PROTEIN
KINASE BTK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 416
ALA A 428
LYS A 430
THR A 474
TYR A 476
MET A 477
GLY A 480
LEU A 528
 None
 0.69A 6bsdA-1k2pA:
23.4		 6bsdA-1k2pA:
15.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k9a CARBOXYL-TERMINAL
SRC KINASE

(Rattus
norvegicus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		10 VAL A 209
ALA A 220
LYS A 222
GLU A 236
MET A 240
THR A 266
TYR A 268
MET A 269
GLY A 272
LEU A 321
 None
 0.73A 6bsdA-1k9aA:
28.7		 6bsdA-1k9aA:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luf MUSCLE-SPECIFIC
TYROSINE KINASE
RECEPTOR MUSK

(Rattus
norvegicus) 		PF07714
(Pkinase_Tyr) 		8 VAL A 588
ALA A 606
LYS A 608
TYR A 656
MET A 657
GLY A 660
LEU A 731
ASP A 742
 None
 1.16A 6bsdA-1lufA:
28.2		 6bsdA-1lufA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1opk PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		9 VAL A 275
ALA A 288
LYS A 290
GLU A 305
MET A 309
THR A 334
MET A 337
GLY A 340
LEU A 389
 P16  A   2 (-4.5A)
P16  A   2 (-3.4A)
P16  A   2 (-4.5A)
P16  A   2 (-4.2A)
P16  A   2 (-3.3A)
P16  A   2 (-3.7A)
None
P16  A   2 (-3.4A)
P16  A   2 (-4.4A)
 0.53A 6bsdA-1opkA:
29.6		 6bsdA-1opkA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1py5 TGF-BETA RECEPTOR
TYPE I

(Homo sapiens) 		PF00069
(Pkinase)
PF08515
(TGF_beta_GS) 		7 VAL A 219
ALA A 230
LYS A 232
GLU A 245
TYR A 282
GLY A 286
LEU A 340
 PY1  A 700 ( 4.7A)
PY1  A 700 (-3.5A)
PY1  A 700 (-3.9A)
PY1  A 700 ( 4.9A)
PY1  A 700 (-4.6A)
PY1  A 700 (-3.6A)
PY1  A 700 (-4.4A)
 0.68A 6bsdA-1py5A:
24.5		 6bsdA-1py5A:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t46 HOMO SAPIENS V-KIT
HARDY-ZUCKERMAN 4
FELINE SARCOMA VIRAL
ONCOGENE HOMOLOG

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 603
ALA A 621
LYS A 623
GLU A 640
THR A 670
TYR A 672
GLY A 676
LEU A 799
 STI  A   3 ( 4.6A)
STI  A   3 (-3.5A)
STI  A   3 (-3.7A)
STI  A   3 (-3.6A)
STI  A   3 (-3.2A)
STI  A   3 ( 4.0A)
STI  A   3 ( 3.8A)
STI  A   3 (-4.4A)
 0.52A 6bsdA-1t46A:
27.8		 6bsdA-1t46A:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u59 TYROSINE-PROTEIN
KINASE ZAP-70

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 352
ALA A 367
LYS A 369
GLU A 386
MET A 390
GLY A 420
LEU A 468
 STU  A 100 (-4.8A)
STU  A 100 (-3.2A)
STU  A 100 ( 4.7A)
None
None
STU  A 100 (-3.5A)
STU  A 100 (-4.5A)
 0.69A 6bsdA-1u59A:
28.5		 6bsdA-1u59A:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u5q SERINE/THREONINE
PROTEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		8 VAL A  42
ALA A  55
LYS A  57
GLU A  76
ILE A  89
TYR A 107
GLY A 110
LEU A 158
 None
 0.54A 6bsdA-1u5qA:
23.1		 6bsdA-1u5qA:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zlt SERINE/THREONINE-PRO
TEIN KINASE CHK1

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  23
ALA A  36
LYS A  38
GLU A  55
TYR A  86
GLY A  90
LEU A 137
 HYM  A 400 (-4.3A)
HYM  A 400 (-3.5A)
HYM  A 400 (-3.2A)
None
HYM  A 400 (-4.7A)
None
HYM  A 400 (-4.5A)
 0.60A 6bsdA-1zltA:
20.8		 6bsdA-1zltA:
15.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dq7 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FYN

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 VAL X  25
ALA X  37
LYS X  39
GLU X  54
MET X  58
THR X  82
TYR X  84
MET X  85
GLY X  88
LEU X 137
 STU  X 902 ( 4.8A)
STU  X 902 (-3.1A)
STU  X 902 (-3.1A)
STU  X 902 ( 4.4A)
None
STU  X 902 (-4.1A)
STU  X 902 (-4.6A)
None
STU  X 902 (-3.5A)
STU  X 902 (-4.4A)
 0.67A 6bsdA-2dq7X:
30.4		 6bsdA-2dq7X:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gcd SERINE/THREONINE-PRO
TEIN KINASE TAO2

(Rattus
norvegicus) 		PF00069
(Pkinase) 		8 VAL A  42
ALA A  55
LYS A  57
GLU A  76
ILE A  89
TYR A 107
GLY A 110
LEU A 158
 STU  A 400 ( 4.8A)
STU  A 400 (-3.2A)
STU  A 400 ( 4.5A)
None
STU  A 400 ( 4.5A)
STU  A 400 (-4.5A)
STU  A 400 (-3.4A)
STU  A 400 ( 4.6A)
 0.68A 6bsdA-2gcdA:
24.0		 6bsdA-2gcdA:
14.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 VAL A 281
ALA A 293
LYS A 295
THR A 338
TYR A 340
MET A 341
LEU A 393
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.7A)
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
None
H8H  A 534 (-4.5A)
 0.59A 6bsdA-2h8hA:
28.9		 6bsdA-2h8hA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h8h PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE SRC

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 VAL A 281
ALA A 293
THR A 338
TYR A 340
MET A 341
GLY A 344
LEU A 393
 H8H  A 534 (-4.4A)
H8H  A 534 (-3.2A)
H8H  A 534 (-3.1A)
H8H  A 534 (-4.3A)
None
H8H  A 534 (-3.3A)
H8H  A 534 (-4.5A)
 0.40A 6bsdA-2h8hA:
28.9		 6bsdA-2h8hA:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hen EPHRIN TYPE-B
RECEPTOR 2

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		8 VAL A 643
ALA A 659
MET A 682
ILE A 691
THR A 707
MET A 710
GLY A 713
LEU A 761
 ADP  A 400 ( 4.4A)
ADP  A 400 (-3.2A)
None
None
ADP  A 400 (-4.7A)
None
ADP  A 400 ( 4.2A)
ADP  A 400 ( 4.7A)
 0.98A 6bsdA-2henA:
30.6		 6bsdA-2henA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hk5 TYROSINE-PROTEIN
KINASE HCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 259
ALA A 271
LYS A 273
GLU A 288
MET A 292
THR A 316
MET A 319
GLY A 322
LEU A 371
 1BM  A 499 ( 4.8A)
1BM  A 499 (-3.6A)
1BM  A 499 (-3.8A)
1BM  A 499 (-3.2A)
1BM  A 499 ( 3.8A)
1BM  A 499 (-3.2A)
None
1BM  A 499 (-3.5A)
1BM  A 499 (-4.4A)
 0.81A 6bsdA-2hk5A:
30.0		 6bsdA-2hk5A:
16.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hz0 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 256
ALA A 269
LYS A 271
GLU A 286
MET A 290
THR A 315
MET A 318
GLY A 321
LEU A 370
 GIN  A 600 ( 4.7A)
GIN  A 600 (-3.1A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.6A)
GIN  A 600 (-3.2A)
GIN  A 600 (-3.4A)
None
None
GIN  A 600 (-4.7A)
 0.58A 6bsdA-2hz0A:
29.9		 6bsdA-2hz0A:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j0j FOCAL ADHESION
KINASE 1

(Gallus gallus) 		PF00373
(FERM_M)
PF07714
(Pkinase_Tyr) 		7 VAL A 436
ALA A 452
LYS A 454
GLU A 471
MET A 475
GLY A 505
LEU A 553
 4ST  A1687 ( 4.8A)
4ST  A1687 (-3.3A)
4ST  A1687 (-3.4A)
4ST  A1687 ( 4.6A)
None
4ST  A1687 (-3.2A)
4ST  A1687 (-4.4A)
 0.61A 6bsdA-2j0jA:
30.4		 6bsdA-2j0jA:
9.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 259
ALA A 271
GLU A 288
MET A 292
THR A 316
TYR A 318
MET A 319
GLY A 322
LEU A 371
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.7A)
1N8  A 501 ( 4.4A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 4.3A)
 0.79A 6bsdA-2og8A:
30.3		 6bsdA-2og8A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2og8 PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE LCK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 259
ALA A 271
LYS A 273
GLU A 288
MET A 292
THR A 316
TYR A 318
GLY A 322
LEU A 371
 None
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.4A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.6A)
1N8  A 501 ( 3.3A)
1N8  A 501 ( 3.7A)
1N8  A 501 ( 3.5A)
1N8  A 501 ( 4.3A)
 0.83A 6bsdA-2og8A:
30.3		 6bsdA-2og8A:
15.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogv MACROPHAGE
COLONY-STIMULATING
FACTOR 1 RECEPTOR
PRECURSOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 596
ALA A 614
GLU A 633
MET A 637
THR A 663
TYR A 665
GLY A 669
LEU A 785
 None
 0.84A 6bsdA-2ogvA:
31.7		 6bsdA-2ogvA:
13.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2phk PHOSPHORYLASE KINASE

(Oryctolagus
cuniculus) 		PF00069
(Pkinase) 		8 VAL A  33
ALA A  46
LYS A  48
GLU A  73
ILE A  87
MET A 106
GLY A 109
LEU A 156
 ATP  A 381 (-4.1A)
ATP  A 381 (-3.5A)
ATP  A 381 (-3.2A)
None
None
None
None
ATP  A 381 ( 4.8A)
 0.49A 6bsdA-2phkA:
22.0		 6bsdA-2phkA:
14.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2psq FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 495
ALA A 515
GLU A 534
MET A 538
ILE A 548
TYR A 566
GLY A 570
LEU A 633
 None
 0.80A 6bsdA-2psqA:
30.1		 6bsdA-2psqA:
15.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 ALA A 651
MET A 674
ILE A 683
THR A 699
MET A 702
GLY A 705
LEU A 753
 PTR  A 701 ( 4.7A)
None
None
None
PTR  A 701 ( 3.5A)
None
None
 0.74A 6bsdA-2qobA:
23.9		 6bsdA-2qobA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qob EPHRIN RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 635
ALA A 651
ILE A 683
THR A 699
MET A 702
GLY A 705
LEU A 753
 BME  A   1 (-4.9A)
PTR  A 701 ( 4.7A)
None
None
PTR  A 701 ( 3.5A)
None
None
 0.68A 6bsdA-2qobA:
23.9		 6bsdA-2qobA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r2p EPHRIN TYPE-A
RECEPTOR 5

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		10 VAL A 689
ALA A 705
GLU A 724
MET A 728
ILE A 737
THR A 753
TYR A 755
MET A 756
GLY A 759
LEU A 807
 None
 0.97A 6bsdA-2r2pA:
31.0		 6bsdA-2r2pA:
15.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r4b RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 732
ALA A 749
LYS A 751
THR A 796
MET A 799
GLY A 802
LEU A 850
 GW7  A   1 ( 4.8A)
GW7  A   1 (-3.3A)
GW7  A   1 (-3.9A)
GW7  A   1 (-4.0A)
None
GW7  A   1 (-3.6A)
GW7  A   1 (-4.2A)
 0.69A 6bsdA-2r4bA:
28.2		 6bsdA-2r4bA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v55 RHO-ASSOCIATED
PROTEIN KINASE 1

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  90
ALA A 103
LYS A 105
GLU A 124
TYR A 155
MET A 156
GLY A 159
LEU A 205
 None
ANP  A1480 ( 3.9A)
ANP  A1480 (-3.4A)
None
ANP  A1480 ( 4.9A)
None
None
ANP  A1480 ( 4.7A)
 0.86A 6bsdA-2v55A:
17.9		 6bsdA-2v55A:
10.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  34
ALA A  47
LYS A  49
GLU A  66
TYR A  97
GLY A 101
LEU A 147
 J60  A1294 ( 4.9A)
J60  A1294 (-3.3A)
None
None
J60  A1294 (-4.5A)
J60  A1294 ( 3.8A)
J60  A1294 (-4.8A)
 0.69A 6bsdA-2xikA:
17.7		 6bsdA-2xikA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xyu EPHRIN TYPE-A
RECEPTOR 4,

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		10 VAL A 635
ALA A 651
LYS A 653
MET A 674
ILE A 683
THR A 699
TYR A 701
MET A 702
GLY A 705
LEU A 753
 Q9G  A1898 ( 4.7A)
Q9G  A1898 (-3.2A)
Q9G  A1898 (-4.8A)
Q9G  A1898 (-3.9A)
Q9G  A1898 ( 4.9A)
Q9G  A1898 (-3.5A)
Q9G  A1898 (-4.8A)
None
Q9G  A1898 ( 3.8A)
Q9G  A1898 (-4.3A)
 0.62A 6bsdA-2xyuA:
31.5		 6bsdA-2xyuA:
15.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y7j PHOSPHORYLASE B
KINASE GAMMA
CATALYTIC CHAIN,
TESTIS/LIVER ISOFORM

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  38
ALA A  51
LYS A  53
ILE A  91
MET A 110
GLY A 113
LEU A 160
 None
B49  A1294 (-3.2A)
None
B49  A1294 ( 4.6A)
None
B49  A1294 (-3.6A)
B49  A1294 (-4.4A)
 0.38A 6bsdA-2y7jA:
23.3		 6bsdA-2y7jA:
11.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b2t FIBROBLAST GROWTH
FACTOR RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 495
ALA A 515
LYS A 517
MET A 538
ILE A 548
TYR A 566
GLY A 570
LEU A 633
 M33  A1996 ( 4.7A)
M33  A1996 (-3.3A)
M33  A1996 ( 4.5A)
None
None
M33  A1996 ( 4.7A)
M33  A1996 ( 4.8A)
M33  A1996 (-4.5A)
 0.80A 6bsdA-3b2tA:
25.1		 6bsdA-3b2tA:
12.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 545
TYR A 563
GLY A 567
LEU A 630
 None
C4F  A   1 (-3.3A)
None
C4F  A   1 ( 3.7A)
C4F  A   1 ( 4.0A)
None
None
C4F  A   1 (-4.6A)
 0.90A 6bsdA-3c4fA:
26.0		 6bsdA-3c4fA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4f BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 492
ALA A 512
LYS A 514
GLU A 531
ILE A 545
TYR A 563
GLY A 567
LEU A 630
 None
C4F  A   1 (-3.3A)
None
None
C4F  A   1 ( 4.0A)
None
None
C4F  A   1 (-4.6A)
 0.91A 6bsdA-3c4fA:
26.0		 6bsdA-3c4fA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d7u TYROSINE-PROTEIN
KINASE CSK

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 VAL A 209
ALA A 220
LYS A 222
GLU A 236
MET A 240
THR A 266
TYR A 268
MET A 269
GLY A 272
LEU A 321
 None
 0.73A 6bsdA-3d7uA:
29.7		 6bsdA-3d7uA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gp0 MITOGEN-ACTIVATED
PROTEIN KINASE 11

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  38
ALA A  51
LYS A  53
GLU A  71
ILE A  84
THR A 106
MET A 109
 NIL  A   1 ( 4.7A)
NIL  A   1 (-3.7A)
None
NIL  A   1 (-3.7A)
NIL  A   1 (-4.4A)
NIL  A   1 (-3.3A)
None
 0.69A 6bsdA-3gp0A:
21.4		 6bsdA-3gp0A:
12.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hng VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 841
ALA A 859
LYS A 861
GLU A 878
TYR A 911
GLY A 915
LEU A1029
 8ST  A2001 ( 4.6A)
8ST  A2001 ( 3.8A)
8ST  A2001 (-4.0A)
8ST  A2001 (-3.7A)
8ST  A2001 (-4.9A)
None
None
 0.65A 6bsdA-3hngA:
32.0		 6bsdA-3hngA:
13.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kul EPHRIN TYPE-A
RECEPTOR 8

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		11 VAL A 649
ALA A 665
LYS A 667
GLU A 684
MET A 688
ILE A 697
THR A 713
TYR A 715
MET A 716
GLY A 719
LEU A 767
 None
None
None
None
None
None
None
GOL  A 403 (-4.1A)
None
GOL  A 403 (-3.4A)
None
 0.84A 6bsdA-3kulA:
26.2		 6bsdA-3kulA:
12.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mdy BONE MORPHOGENETIC
PROTEIN RECEPTOR
TYPE-1B

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF08515
(TGF_beta_GS) 		8 VAL A 218
ALA A 229
LYS A 231
GLU A 244
THR A 279
TYR A 281
GLY A 285
LEU A 339
 LDN  A   1 ( 4.8A)
LDN  A   1 (-3.6A)
None
None
LDN  A   1 (-3.8A)
LDN  A   1 ( 4.8A)
LDN  A   1 (-3.3A)
LDN  A   1 (-4.5A)
 0.41A 6bsdA-3mdyA:
23.9		 6bsdA-3mdyA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mvj CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  57
ALA A  70
LYS A  72
GLU A  91
TYR A 122
GLY A 126
LEU A 173
 XFE  A 351 ( 4.5A)
XFE  A 351 (-3.2A)
None
None
None
None
XFE  A 351 (-4.6A)
 0.61A 6bsdA-3mvjA:
20.3		 6bsdA-3mvjA:
9.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3my0 SERINE/THREONINE-PRO
TEIN KINASE RECEPTOR
R3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 216
ALA A 227
LYS A 229
THR A 277
TYR A 279
GLY A 283
LEU A 337
 LDN  A 600 (-4.5A)
LDN  A 600 (-3.2A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.0A)
LDN  A 600 (-4.7A)
LDN  A 600 (-3.3A)
LDN  A 600 (-4.6A)
 0.67A 6bsdA-3my0A:
23.9		 6bsdA-3my0A:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nuu PKB-LIKE

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  96
ALA A 109
LYS A 111
GLU A 130
MET A 134
TYR A 161
GLY A 165
LEU A 212
 JOZ  A 361 ( 4.7A)
JOZ  A 361 (-3.4A)
SO4  A   5 (-2.8A)
SO4  A   5 (-3.1A)
None
None
None
None
 0.70A 6bsdA-3nuuA:
22.8		 6bsdA-3nuuA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nyo G PROTEIN-COUPLED
RECEPTOR KINASE 6

(Homo sapiens) 		PF00069
(Pkinase)
PF00615
(RGS) 		7 VAL A 200
ALA A 213
LYS A 215
GLU A 234
MET A 266
GLY A 269
LEU A 318
 AMP  A 577 (-4.3A)
AMP  A 577 (-3.4A)
AMP  A 577 (-2.8A)
None
None
None
AMP  A 577 (-4.8A)
 0.73A 6bsdA-3nyoA:
20.8		 6bsdA-3nyoA:
9.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oht P38A

(Salmo salar) 		PF00069
(Pkinase) 		8 VAL A  39
ALA A  52
LYS A  54
GLU A  72
ILE A  85
THR A 107
GLY A 111
ASP A 169
 1N1  A1000 (-4.6A)
1N1  A1000 (-3.7A)
1N1  A1000 (-4.5A)
1N1  A1000 (-4.2A)
1N1  A1000 ( 4.1A)
1N1  A1000 (-3.3A)
1N1  A1000 (-4.7A)
1N1  A1000 (-3.4A)
 0.73A 6bsdA-3ohtA:
8.3		 6bsdA-3ohtA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oht P38A

(Salmo salar) 		PF00069
(Pkinase) 		8 VAL A  39
ALA A  52
LYS A  54
GLU A  72
ILE A  85
THR A 107
MET A 110
ASP A 169
 1N1  A1000 (-4.6A)
1N1  A1000 (-3.7A)
1N1  A1000 (-4.5A)
1N1  A1000 (-4.2A)
1N1  A1000 ( 4.1A)
1N1  A1000 (-3.3A)
None
1N1  A1000 (-3.4A)
 0.60A 6bsdA-3ohtA:
8.3		 6bsdA-3ohtA:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pp0 RECEPTOR
TYROSINE-PROTEIN
KINASE ERBB-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 734
ALA A 751
LYS A 753
THR A 798
MET A 801
GLY A 804
LEU A 852
 03Q  A   1 (-4.5A)
03Q  A   1 (-3.1A)
03Q  A   1 (-4.7A)
03Q  A   1 (-4.1A)
None
03Q  A   1 ( 3.9A)
03Q  A   1 (-4.4A)
 0.46A 6bsdA-3pp0A:
28.4		 6bsdA-3pp0A:
12.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		8 ALA A 576
LYS A 578
GLU A 596
MET A 600
THR A 625
TYR A 627
GLY A 631
LEU A 683
 STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
None
None
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.61A 6bsdA-3ppzA:
27.6		 6bsdA-3ppzA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		7 VAL A 565
ALA A 576
LYS A 578
THR A 625
TYR A 627
GLY A 631
LEU A 683
 STU  A   1 (-4.9A)
STU  A   1 (-3.3A)
STU  A   1 (-3.5A)
STU  A   1 (-4.1A)
STU  A   1 (-4.4A)
STU  A   1 (-3.2A)
STU  A   1 (-4.3A)
 0.59A 6bsdA-3ppzA:
27.6		 6bsdA-3ppzA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sxs CYTOPLASMIC
TYROSINE-PROTEIN
KINASE BMX

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 431
ALA A 443
MET A 464
THR A 489
TYR A 491
GLY A 495
LEU A 543
 PP2  A   1 (-4.5A)
PP2  A   1 (-3.2A)
PP2  A   1 ( 4.3A)
PP2  A   1 (-3.3A)
PP2  A   1 ( 4.9A)
PP2  A   1 ( 4.2A)
PP2  A   1 (-4.6A)
 0.67A 6bsdA-3sxsA:
29.3		 6bsdA-3sxsA:
16.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 492
ALA A 512
LYS A 514
GLU A 531
MET A 535
ILE A 545
GLY A 567
LEU A 630
 07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-4.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.8A)
07J  A   1 (-3.8A)
07J  A   1 (-3.7A)
07J  A   1 ( 4.4A)
 0.78A 6bsdA-3tt0A:
30.8		 6bsdA-3tt0A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tt0 BASIC FIBROBLAST
GROWTH FACTOR
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 492
ALA A 512
LYS A 514
GLU A 531
MET A 535
TYR A 563
GLY A 567
LEU A 630
 07J  A   1 (-4.0A)
07J  A   1 (-3.5A)
07J  A   1 (-4.5A)
07J  A   1 (-3.8A)
07J  A   1 (-3.8A)
07J  A   1 (-4.7A)
07J  A   1 (-3.7A)
07J  A   1 ( 4.4A)
 0.71A 6bsdA-3tt0A:
30.8		 6bsdA-3tt0A:
14.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v5q NT-3 GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 552
ALA A 570
LYS A 572
TYR A 619
MET A 620
GLY A 623
LEU A 686
 None
0F4  A 902 (-3.2A)
0F4  A 902 (-4.0A)
0F4  A 902 (-4.2A)
None
0F4  A 902 (-3.4A)
0F4  A 902 (-4.5A)
 0.69A 6bsdA-3v5qA:
28.2		 6bsdA-3v5qA:
14.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zfx EPHRIN TYPE-B
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 633
ALA A 649
GLU A 668
MET A 672
ILE A 681
THR A 697
MET A 700
GLY A 703
LEU A 751
 None
 0.89A 6bsdA-3zfxA:
30.1		 6bsdA-3zfxA:
17.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4at3 BDNF/NT-3 GROWTH
FACTORS RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 568
ALA A 586
LYS A 588
TYR A 635
MET A 636
GLY A 639
LEU A 699
 None
LTI  A1839 (-3.3A)
None
LTI  A1839 (-4.7A)
None
LTI  A1839 (-3.4A)
LTI  A1839 (-4.2A)
 0.62A 6bsdA-4at3A:
31.7		 6bsdA-4at3A:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw2 SERINE/THREONINE-PRO
TEIN KINASE MRCK
ALPHA

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 VAL A  91
ALA A 104
LYS A 106
GLU A 125
TYR A 156
GLY A 160
LEU A 208
 None
EDO  A1420 (-3.4A)
EDO  A1419 (-3.3A)
EDO  A1419 (-3.0A)
EDO  A1420 (-4.9A)
None
EDO  A1420 ( 4.8A)
 0.50A 6bsdA-4aw2A:
19.3		 6bsdA-4aw2A:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 105
ALA A 121
LYS A 123
MET A 144
ILE A 153
THR A 169
MET A 172
LEU A 223
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
30K  A1365 (-3.8A)
None
None
30K  A1365 (-3.8A)
None
30K  A1365 (-4.5A)
 0.90A 6bsdA-4aw5A:
30.9		 6bsdA-4aw5A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aw5 EPHRIN TYPE-B
RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 105
ALA A 121
MET A 144
ILE A 153
THR A 169
MET A 172
GLY A 175
LEU A 223
 30K  A1365 ( 4.6A)
30K  A1365 (-3.2A)
None
None
30K  A1365 (-3.8A)
None
30K  A1365 (-3.5A)
30K  A1365 (-4.5A)
 0.85A 6bsdA-4aw5A:
30.9		 6bsdA-4aw5A:
20.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c0t LIKELY PROTEIN
KINASE

(Candida
albicans) 		PF00069
(Pkinase) 		8 VAL A 254
ALA A 267
LYS A 269
GLU A 288
ILE A 302
TYR A 320
GLY A 324
LEU A 371
 None
 0.76A 6bsdA-4c0tA:
21.5		 6bsdA-4c0tA:
6.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cfh 5'-AMP-ACTIVATED
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA-1

(Rattus
norvegicus) 		PF00069
(Pkinase)
PF16579
(AdenylateSensor) 		7 VAL A  30
ALA A  43
LYS A  45
GLU A  64
TYR A  95
GLY A  99
LEU A 146
 None
STU  A1550 (-3.1A)
STU  A1550 (-3.6A)
None
STU  A1550 (-4.5A)
STU  A1550 (-3.4A)
STU  A1550 (-4.3A)
 0.64A 6bsdA-4cfhA:
14.8		 6bsdA-4cfhA:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 ALA A 653
LYS A 655
GLU A 672
MET A 676
ILE A 685
THR A 701
TYR A 703
MET A 704
GLY A 707
LEU A 773
 DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.5A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.0A)
None
None
DI1  A1000 (-4.5A)
 0.65A 6bsdA-4ckrA:
38.5		 6bsdA-4ckrA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ckr EPITHELIAL DISCOIDIN
DOMAIN-CONTAINING
RECEPTOR 1

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		10 VAL A 624
ALA A 653
LYS A 655
GLU A 672
MET A 676
ILE A 685
THR A 701
TYR A 703
MET A 704
LEU A 773
 DI1  A1000 (-4.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-3.9A)
DI1  A1000 (-3.8A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.5A)
DI1  A1000 (-3.6A)
DI1  A1000 (-4.0A)
None
DI1  A1000 (-4.5A)
 0.73A 6bsdA-4ckrA:
38.5		 6bsdA-4ckrA:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crs SERINE/THREONINE-PRO
TEIN KINASE N2

(Homo sapiens) 		PF00069
(Pkinase)
PF00433
(Pkinase_C) 		7 VAL A 671
ALA A 684
LYS A 686
GLU A 705
TYR A 739
GLY A 743
LEU A 789
 AGS  A1985 (-4.6A)
AGS  A1985 (-3.5A)
AGS  A1985 (-3.0A)
None
None
None
AGS  A1985 (-4.8A)
 0.69A 6bsdA-4crsA:
20.3		 6bsdA-4crsA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gl9 TYROSINE-PROTEIN
KINASE

(Mus musculus) 		PF07714
(Pkinase_Tyr) 		7 VAL A 863
ALA A 880
LYS A 882
GLU A 898
TYR A 931
GLY A 935
LEU A 983
 None
IZA  A2001 (-3.4A)
IZA  A2001 ( 4.7A)
None
None
IZA  A2001 (-3.3A)
IZA  A2001 ( 4.7A)
 0.67A 6bsdA-4gl9A:
28.5		 6bsdA-4gl9A:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hvi TYROSINE-PROTEIN
KINASE JAK3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 836
ALA A 853
LYS A 855
GLU A 871
TYR A 904
GLY A 908
LEU A 956
 19S  A1201 (-4.4A)
19S  A1201 (-3.3A)
19S  A1201 (-3.5A)
None
19S  A1201 (-4.7A)
19S  A1201 ( 3.8A)
19S  A1201 (-4.5A)
 0.31A 6bsdA-4hviA:
29.1		 6bsdA-4hviA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k33 FIBROBLAST GROWTH
FACTOR RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 486
ALA A 506
LYS A 508
GLU A 525
MET A 529
ILE A 539
TYR A 557
GLY A 561
LEU A 624
 ACP  A 801 (-4.2A)
ACP  A 801 (-3.3A)
ACP  A 801 (-2.7A)
ACP  A 801 ( 4.8A)
None
None
None
ACP  A 801 ( 4.6A)
ACP  A 801 (-4.4A)
 0.78A 6bsdA-4k33A:
26.2		 6bsdA-4k33A:
13.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l52 MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE 7,
TGF-BETA-ACTIVATED
KINASE 1 AND
MAP3K7-BINDING
PROTEIN 1 CHIMERA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A  50
ALA A  61
LYS A  63
GLU A  77
TYR A 106
GLY A 110
LEU A 163
 1UL  A 501 ( 4.9A)
1UL  A 501 (-3.1A)
None
None
1UL  A 501 (-4.1A)
1UL  A 501 ( 3.7A)
1UL  A 501 (-4.3A)
 0.45A 6bsdA-4l52A:
18.3		 6bsdA-4l52A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o27 SERINE/THREONINE-PRO
TEIN KINASE 24

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL B  38
ALA B  51
LYS B  53
GLU B  70
TYR B 101
GLY B 105
LEU B 151
 ADP  B 500 (-4.5A)
ADP  B 500 (-3.3A)
ADP  B 500 (-3.1A)
None
ADP  B 500 ( 4.7A)
None
ADP  B 500 (-4.7A)
 0.62A 6bsdA-4o27B:
18.3		 6bsdA-4o27B:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		8 VAL A  54
ALA A  67
LYS A  69
GLU A  85
MET A  89
THR A 123
GLY A 128
LEU A 180
 None
SIN  A 401 ( 3.7A)
None
None
None
None
SIN  A 401 (-3.5A)
SIN  A 401 ( 4.5A)
 0.79A 6bsdA-4o38A:
19.4		 6bsdA-4o38A:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oli NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 911
ALA A 928
LYS A 930
GLU A 947
TYR A 980
GLY A 984
LEU A1030
 2TT  A1202 (-4.5A)
2TT  A1202 ( 3.9A)
None
None
2TT  A1202 (-4.6A)
2TT  A1202 (-3.4A)
2TT  A1202 (-4.4A)
 0.61A 6bsdA-4oliA:
25.5		 6bsdA-4oliA:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2k EPHRIN TYPE-A
RECEPTOR 2

(Homo sapiens) 		PF07714
(Pkinase_Tyr)
PF14575
(EphA2_TM) 		7 VAL A 627
ALA A 644
THR A 692
TYR A 694
MET A 695
GLY A 698
LEU A 746
 None
 0.58A 6bsdA-4p2kA:
31.2		 6bsdA-4p2kA:
12.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qny MITOGEN ACTIVATED
PROTEIN KINASE,
PUTATIVE

(Leishmania
donovani) 		PF00069
(Pkinase) 		7 VAL A  35
ALA A  49
LYS A  51
GLU A  70
ILE A  83
MET A 107
LEU A 156
 ANP  A 402 (-4.3A)
ANP  A 402 (-3.3A)
ANP  A 402 (-2.8A)
ANP  A 402 (-3.0A)
ANP  A 402 (-4.8A)
None
ANP  A 402 (-4.6A)
 0.64A 6bsdA-4qnyA:
20.9		 6bsdA-4qnyA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rt7 RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 624
ALA A 642
LYS A 644
GLU A 661
TYR A 693
GLY A 697
LEU A 818
 None
P30  A1001 (-3.4A)
P30  A1001 (-3.4A)
P30  A1001 (-3.6A)
P30  A1001 (-4.1A)
P30  A1001 (-3.4A)
P30  A1001 (-4.6A)
 0.54A 6bsdA-4rt7A:
28.0		 6bsdA-4rt7A:
12.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		9 ALA A  35
LYS A  37
GLU A  52
MET A  56
THR A  81
TYR A  83
MET A  84
GLY A  87
LEU A 136
 ACP  A1264 (-2.9A)
None
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
None
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.92A 6bsdA-4ueuA:
29.9		 6bsdA-4ueuA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		9 VAL A  22
ALA A  35
LYS A  37
GLU A  52
THR A  81
TYR A  83
MET A  84
GLY A  87
LEU A 136
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 (-4.5A)
ACP  A1264 ( 4.5A)
None
ACP  A1264 (-3.5A)
ACP  A1264 ( 4.8A)
 0.86A 6bsdA-4ueuA:
29.9		 6bsdA-4ueuA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ueu TYROSINE KINASE AS -
A COMMON ANCESTOR OF
SRC AND ABL

(synthetic
construct) 		PF07714
(Pkinase_Tyr) 		8 VAL A  22
ALA A  35
LYS A  37
GLU A  52
TYR A  83
MET A  84
LEU A 136
ASP A 147
 ACP  A1264 (-4.7A)
ACP  A1264 (-2.9A)
None
None
ACP  A1264 ( 4.5A)
None
ACP  A1264 ( 4.8A)
None
 1.32A 6bsdA-4ueuA:
29.9		 6bsdA-4ueuA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wb7 DNAJ HOMOLOG
SUBFAMILY B MEMBER
1,CAMP-DEPENDENT
PROTEIN KINASE
CATALYTIC SUBUNIT
ALPHA

(Homo sapiens) 		PF00069
(Pkinase)
PF00226
(DnaJ) 		7 VAL A 112
ALA A 125
LYS A 127
GLU A 146
TYR A 177
GLY A 181
LEU A 228
 ATP  A 501 (-4.0A)
ATP  A 501 (-3.4A)
ATP  A 501 (-2.6A)
None
None
None
ATP  A 501 (-4.5A)
 0.53A 6bsdA-4wb7A:
20.3		 6bsdA-4wb7A:
9.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xcu FIBROBLAST GROWTH
FACTOR RECEPTOR 4

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 481
ALA A 501
LYS A 503
GLU A 520
MET A 524
ILE A 534
GLY A 556
LEU A 619
 40M  A1002 ( 4.5A)
40M  A1002 ( 4.1A)
40M  A1002 (-4.0A)
40M  A1002 (-3.7A)
40M  A1002 (-3.8A)
40M  A1002 (-4.0A)
40M  A1002 ( 3.7A)
40M  A1002 (-4.5A)
 0.87A 6bsdA-4xcuA:
30.2		 6bsdA-4xcuA:
15.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xey TYROSINE-PROTEIN
KINASE ABL1

(Homo sapiens) 		no annotation 7 VAL B 275
ALA B 288
MET B 309
THR B 334
MET B 337
GLY B 340
LEU B 389
 1N1  B 601 ( 4.9A)
1N1  B 601 (-3.5A)
1N1  B 601 (-3.7A)
1N1  B 601 (-3.3A)
None
1N1  B 601 (-3.5A)
1N1  B 601 (-4.3A)
 0.57A 6bsdA-4xeyB:
24.3		 6bsdA-4xeyB:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xi2 TYROSINE-PROTEIN
KINASE BTK

(Mus musculus) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07714
(Pkinase_Tyr) 		7 VAL A 416
ALA A 428
THR A 474
TYR A 476
MET A 477
GLY A 480
LEU A 528
 None
 0.73A 6bsdA-4xi2A:
25.3		 6bsdA-4xi2A:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xuf RECEPTOR-TYPE
TYROSINE-PROTEIN
KINASE FLT3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 624
ALA A 642
LYS A 644
GLU A 661
TYR A 693
GLY A 697
LEU A 818
 P30  A1001 ( 4.8A)
P30  A1001 (-3.5A)
P30  A1001 ( 4.0A)
P30  A1001 (-3.1A)
P30  A1001 ( 4.4A)
P30  A1001 (-3.5A)
P30  A1001 (-4.3A)
 0.41A 6bsdA-4xufA:
31.8		 6bsdA-4xufA:
14.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y93 NON-SPECIFIC
PROTEIN-TYROSINE
KINASE,NON-SPECIFIC
PROTEIN-TYROSINE
KINASE

(Bos taurus) 		PF00169
(PH)
PF00779
(BTK)
PF07714
(Pkinase_Tyr) 		7 VAL A 416
ALA A 428
THR A 474
TYR A 476
MET A 477
GLY A 480
LEU A 528
 746  A 702 ( 4.3A)
746  A 702 (-2.4A)
746  A 702 (-3.7A)
746  A 702 (-4.4A)
None
746  A 702 (-3.6A)
746  A 702 (-4.4A)
 0.35A 6bsdA-4y93A:
29.9		 6bsdA-4y93A:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yff SERINE/THREONINE-PRO
TEIN KINASE TNNI3K

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 477
ALA A 488
LYS A 490
GLU A 509
ILE A 522
THR A 539
TYR A 541
GLY A 545
LEU A 595
 None
4CV  A 801 (-3.5A)
4CV  A 801 (-3.9A)
None
4CV  A 801 ( 4.2A)
4CV  A 801 (-2.8A)
4CV  A 801 (-3.9A)
4CV  A 801 ( 4.0A)
4CV  A 801 (-4.4A)
 0.75A 6bsdA-4yffA:
23.4		 6bsdA-4yffA:
15.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 492
ALA A 512
GLU A 531
MET A 535
ILE A 545
TYR A 563
GLY A 567
LEU A 630
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 ( 3.3A)
38O  A1769 (-4.2A)
38O  A1769 (-3.4A)
38O  A1769 (-4.6A)
 0.82A 6bsdA-5a46A:
31.0		 6bsdA-5a46A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a46 FIBROBLAST GROWTH
FACTOR RECEPTOR 1
(FMS-RELATED
TYROSINE KINASE 2,
PFEIFFER SYNDROME),
ISOFORM CRA_B

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 492
ALA A 512
LYS A 514
GLU A 531
MET A 535
ILE A 545
TYR A 563
GLY A 567
 38O  A1769 (-4.5A)
38O  A1769 (-3.6A)
38O  A1769 ( 3.1A)
EDO  A1766 (-4.1A)
EDO  A1766 (-3.5A)
38O  A1769 ( 3.3A)
38O  A1769 (-4.2A)
38O  A1769 (-3.4A)
 0.87A 6bsdA-5a46A:
31.0		 6bsdA-5a46A:
13.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e8y TGF-BETA RECEPTOR
TYPE-2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		7 VAL A 258
ALA A 275
LYS A 277
GLU A 290
THR A 325
GLY A 331
LEU A 386
 STU  A 601 (-4.0A)
STU  A 601 (-3.1A)
STU  A 601 (-2.4A)
STU  A 601 ( 3.8A)
STU  A 601 ( 3.7A)
STU  A 601 (-3.5A)
STU  A 601 (-3.9A)
 0.60A 6bsdA-5e8yA:
24.2		 6bsdA-5e8yA:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5es1 MAP/MICROTUBULE
AFFINITY-REGULATING
KINASE 4

(Homo sapiens) 		PF00069
(Pkinase)
PF00627
(UBA) 		7 VAL A  70
ALA A  83
LYS A  85
GLU A 103
TYR A 134
GLY A 138
LEU A 185
 5RC  A4000 (-4.6A)
5RC  A4000 (-3.6A)
5RC  A4000 (-2.8A)
None
5RC  A4000 (-4.5A)
5RC  A4000 (-3.3A)
None
 0.72A 6bsdA-5es1A:
22.0		 6bsdA-5es1A:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f1z NON-RECEPTOR
TYROSINE-PROTEIN
KINASE TYK2

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 911
ALA A 928
LYS A 930
GLU A 947
ILE A 960
TYR A 980
GLY A 984
LEU A1030
 5U3  A1200 ( 4.4A)
5U3  A1200 (-3.5A)
None
None
5U3  A1200 (-4.6A)
5U3  A1200 (-4.5A)
5U3  A1200 (-3.2A)
5U3  A1200 (-4.4A)
 0.70A 6bsdA-5f1zA:
27.4		 6bsdA-5f1zA:
13.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5grn PLATELET-DERIVED
GROWTH FACTOR
RECEPTOR ALPHA

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		9 VAL A 607
ALA A 625
LYS A 627
GLU A 644
MET A 648
THR A 674
TYR A 676
GLY A 680
LEU A 825
 748  A1001 ( 4.7A)
748  A1001 (-3.7A)
748  A1001 (-4.0A)
748  A1001 (-3.3A)
748  A1001 (-3.4A)
748  A1001 (-3.2A)
748  A1001 (-4.0A)
748  A1001 ( 4.0A)
748  A1001 (-4.3A)
 0.60A 6bsdA-5grnA:
26.3		 6bsdA-5grnA:
12.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  65
ALA A  77
LYS A  79
GLU A  95
MET A  99
GLY A 136
LEU A 187
 IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
None
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.73A 6bsdA-5i3oA:
21.4		 6bsdA-5i3oA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i3o BMP-2-INDUCIBLE
PROTEIN KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  65
ALA A  77
LYS A  79
MET A  99
TYR A 132
GLY A 136
LEU A 187
 IDV  A 401 (-4.6A)
IDV  A 401 (-3.6A)
IDV  A 401 ( 4.8A)
None
IDV  A 401 (-3.5A)
IDV  A 401 (-3.4A)
IDV  A 401 (-4.4A)
 0.67A 6bsdA-5i3oA:
21.4		 6bsdA-5i3oA:
11.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j5t MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE KINASE
3

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A  30
ALA A  43
LYS A  45
GLU A  61
MET A  65
GLY A  96
LEU A 143
 6G2  A 901 ( 4.9A)
6G2  A 901 (-3.2A)
6G2  A 901 ( 3.9A)
None
None
6G2  A 901 (-3.6A)
6G2  A 901 (-4.7A)
 0.55A 6bsdA-5j5tA:
20.9		 6bsdA-5j5tA:
13.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j9z EPIDERMAL GROWTH
FACTOR RECEPTOR

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 726
ALA A 743
LYS A 745
GLU A 762
MET A 766
MET A 793
GLY A 796
LEU A 844
 6HJ  A1101 ( 4.7A)
6HJ  A1101 (-3.1A)
6HJ  A1101 (-4.2A)
6HJ  A1101 ( 4.2A)
6HJ  A1101 ( 4.1A)
None
6HJ  A1101 ( 4.5A)
6HJ  A1101 ( 4.8A)
 0.79A 6bsdA-5j9zA:
29.6		 6bsdA-5j9zA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kbr SERINE/THREONINE-PRO
TEIN KINASE PAK 1

(Homo sapiens) 		PF00069
(Pkinase) 		7 VAL A 284
ALA A 297
GLU A 315
MET A 319
TYR A 346
GLY A 350
LEU A 396
 IPW  A 601 (-4.2A)
IPW  A 601 (-3.5A)
IPW  A 601 (-3.9A)
IPW  A 601 (-4.1A)
IPW  A 601 (-4.5A)
IPW  A 601 ( 3.8A)
IPW  A 601 (-4.5A)
 0.72A 6bsdA-5kbrA:
21.1		 6bsdA-5kbrA:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l6o EPHRIN TYPE-B
RECEPTOR 3

(Homo sapiens) 		PF07714
(Pkinase_Tyr) 		8 VAL A 647
ALA A 663
LYS A 665
MET A 686
ILE A 695
THR A 711
MET A 714
LEU A 765
 None
6P6  A1001 (-3.3A)
None
6P6  A1001 ( 4.2A)
None
6P6  A1001 (-3.5A)
None
6P6  A1001 (-4.5A)
 0.73A 6bsdA-5l6oA:
31.9		 6bsdA-5l6oA:
17.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvt MATERNAL EMBRYONIC
LEUCINE ZIPPER
KINASE

(Homo sapiens) 		no annotation 8 VAL A  25
ALA A  38
LYS A  40
GLU A  57
TYR A  88
GLY A  92
LEU A 139
ASP A 150
 7LV  A 401 ( 4.6A)
7LV  A 401 (-3.4A)
7LV  A 401 (-3.0A)
7LV  A 401 (-3.5A)
7LV  A 401 (-4.6A)
None
7LV  A 401 (-4.9A)
7LV  A 401 (-4.2A)
 1.39A 6bsdA-5tvtA:
21.9		 6bsdA-5tvtA:
15.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w5j RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 2

(Homo sapiens) 		no annotation 7 VAL A  32
ALA A  45
THR A  95
TYR A  97
MET A  98
GLY A 101
LEU A 153
 9WS  A 401 ( 4.6A)
9WS  A 401 (-3.3A)
9WS  A 401 (-3.2A)
None
None
9WS  A 401 ( 4.3A)
9WS  A 401 (-4.6A)
 0.34A 6bsdA-5w5jA:
22.4		 6bsdA-5w5jA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4

(Mus musculus) 		no annotation 9 VAL A  36
ALA A  49
LYS A  51
GLU A  69
MET A  73
TYR A  98
MET A  99
GLY A 102
LEU A 150
 VX6  A 402 (-4.6A)
VX6  A 402 (-3.2A)
VX6  A 402 (-4.9A)
VX6  A 402 (-4.4A)
None
VX6  A 402 (-4.3A)
None
VX6  A 402 (-3.5A)
VX6  A 402 (-4.4A)
 0.87A 6bsdA-5wnmA:
25.8		 6bsdA-5wnmA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wnm RECEPTOR-INTERACTING
SERINE/THREONINE-PRO
TEIN KINASE 4

(Mus musculus) 		no annotation 8 VAL A  36
ALA A  49
LYS A  51
GLU A  69
TYR A  98
MET A  99
LEU A 150
ASP A 161
 VX6  A 402 (-4.6A)
VX6  A 402 (-3.2A)
VX6  A 402 (-4.9A)
VX6  A 402 (-4.4A)
VX6  A 402 (-4.3A)
None
VX6  A 402 (-4.4A)
VX6  A 402 (-4.3A)
 1.45A 6bsdA-5wnmA:
25.8		 6bsdA-5wnmA:
22.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wno RECEPTOR
TYROSINE-PROTEIN
KINASE LET-23

(Caenorhabditis
elegans) 		no annotation 7 VAL A 899
ALA A 917
LYS A 919
THR A 963
TYR A 965
GLY A 969
LEU A1017
 ANP  A1201 (-4.4A)
ANP  A1201 (-3.3A)
ANP  A1201 (-3.8A)
ANP  A1201 (-3.9A)
ANP  A1201 (-4.4A)
ANP  A1201 ( 4.6A)
ANP  A1201 (-4.7A)
 0.46A 6bsdA-5wnoA:
25.9		 6bsdA-5wnoA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6b3e CYCLIN-DEPENDENT
KINASE 12

(Homo sapiens) 		no annotation 7 VAL A 741
ALA A 754
LYS A 756
GLU A 774
TYR A 815
MET A 816
LEU A 866
 None
CJM  A1102 (-3.1A)
None
None
CJM  A1102 (-4.1A)
None
CJM  A1102 (-4.4A)
 0.50A 6bsdA-6b3eA:
22.3		 6bsdA-6b3eA:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f3d INTERLEUKIN-1
RECEPTOR-ASSOCIATED
KINASE 4

(Homo sapiens) 		no annotation 7 VAL A 200
ALA A 211
LYS A 213
TYR A 264
MET A 265
GLY A 268
LEU A 318
 CJT  A 502 ( 4.8A)
CJT  A 502 (-3.4A)
CJT  A 502 (-3.0A)
CJT  A 502 (-4.5A)
CJT  A 502 (-4.9A)
CJT  A 502 ( 4.3A)
CJT  A 502 (-4.7A)
 0.43A 6bsdA-6f3dA:
22.5		 6bsdA-6f3dA:
17.24