SIMILAR PATTERNS OF AMINO ACIDS FOR 6BRD_C_RFPC502_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a0d XYLOSE ISOMERASE

(Geobacillus
stearothermophilus) 		PF01261
(AP_endonuc_2) 		5 GLY A 332
VAL A 292
PHE A 276
THR A 315
GLY A 363
 None
 0.79A 6brdC-1a0dA:
undetectable		 6brdC-1a0dA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ak2 ADENYLATE KINASE
ISOENZYME-2

(Bos taurus) 		PF00406
(ADK)
PF05191
(ADK_lid) 		5 VAL A  20
VAL A 126
MET A 116
ARG A 119
GLY A  16
 None
 1.17A 6brdC-1ak2A:
undetectable		 6brdC-1ak2A:
18.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1azz COLLAGENASE

(Leptuca
pugilator) 		PF00089
(Trypsin) 		5 VAL A 158
VAL A 160
GLY A 216
THR A 229
GLY A 211
 None
 1.17A 6brdC-1azzA:
undetectable		 6brdC-1azzA:
15.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bxc XYLOSE ISOMERASE

(Thermus
caldophilus) 		PF01261
(AP_endonuc_2) 		5 ARG A 187
GLY A 101
ARG A 111
THR A 147
GLY A 148
 None
 1.13A 6brdC-1bxcA:
undetectable		 6brdC-1bxcA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cg4 PROTEIN
(ADENYLOSUCCINATE
SYNTHETASE)

(Escherichia
coli) 		PF00709
(Adenylsucc_synt) 		5 VAL A 262
VAL A 259
GLY A  71
VAL A  72
PRO A  56
 None
 1.10A 6brdC-1cg4A:
undetectable		 6brdC-1cg4A:
13.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dcu FRUCTOSE-1,6-BISPHOS
PHATASE

(Pisum sativum) 		PF00316
(FBPase) 		5 VAL A 199
VAL A 206
GLY A 320
VAL A 327
PRO A 180
 None
 1.10A 6brdC-1dcuA:
undetectable		 6brdC-1dcuA:
11.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ded CYCLODEXTRIN
GLUCANOTRANSFERASE

(Bacillus sp.
1011) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		5 VAL A 231
GLY A 225
VAL A 223
PHE A 118
PRO A  79
 None
 1.00A 6brdC-1dedA:
undetectable		 6brdC-1dedA:
8.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gll GLYCEROL KINASE

(Escherichia
coli) 		no annotation 5 VAL Y  30
VAL Y  19
GLY Y 410
THR Y  13
GLY Y  12
 None
None
ACP  Y 601 ( 4.2A)
ACP  Y 601 (-3.4A)
ACP  Y 601 (-2.9A)
 1.04A 6brdC-1gllY:
undetectable		 6brdC-1gllY:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iir GLYCOSYLTRANSFERASE
GTFB

(Amycolatopsis
orientalis) 		PF03033
(Glyco_transf_28) 		5 VAL A 196
GLY A 338
VAL A 340
THR A 313
GLY A 312
 None
None
None
SO4  A1403 (-3.8A)
SO4  A1403 (-3.3A)
 0.81A 6brdC-1iirA:
0.8		 6brdC-1iirA:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j6u UDP-N-ACETYLMURAMATE
-ALANINE LIGASE MURC

(Thermotoga
maritima) 		PF01225
(Mur_ligase)
PF02875
(Mur_ligase_C)
PF08245
(Mur_ligase_M) 		5 VAL A 120
VAL A 273
ARG A 300
THR A 110
GLY A 109
 None
 1.13A 6brdC-1j6uA:
3.2		 6brdC-1j6uA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mty METHANE
MONOOXYGENASE
HYDROXYLASE

(Methylococcus
capsulatus) 		PF02332
(Phenol_Hydrox) 		5 VAL B 177
MET B  35
VAL D 154
PHE D 236
GLY D 113
 None
 1.04A 6brdC-1mtyB:
undetectable		 6brdC-1mtyB:
11.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ogy DIHEME CYTOCHROME C
NAPB MOLECULE:
NITRATE REDUCTASE
PERIPLASMIC NITRATE
REDUCTASE

(Rhodobacter
sphaeroides) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF03892
(NapB)
PF04879
(Molybdop_Fe4S4) 		5 VAL A 627
ARG B  83
PHE A 379
THR A  24
GLY A  25
 None
None
None
SF4  A1801 ( 4.2A)
SF4  A1801 ( 4.3A)
 1.10A 6brdC-1ogyA:
undetectable		 6brdC-1ogyA:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1poi GLUTACONATE COENZYME
A-TRANSFERASE

(Acidaminococcus
fermentans) 		PF01144
(CoA_trans) 		5 VAL A 105
ARG A 141
GLY A 135
THR A  48
GLY A  49
 None
 1.19A 6brdC-1poiA:
undetectable		 6brdC-1poiA:
13.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1scj SUBTILISIN E

(Bacillus
subtilis) 		PF00082
(Peptidase_S8)
PF05922
(Inhibitor_I9) 		5 VAL B 344
VAL A 138
GLY A 102
THR A 130
GLY A 131
 None
 1.15A 6brdC-1scjB:
undetectable		 6brdC-1scjB:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uxi MALATE DEHYDROGENASE

(Chloroflexus
aurantiacus) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 VAL A 276
VAL A 269
GLY A 174
VAL A 299
GLY A 256
 None
 1.15A 6brdC-1uxiA:
4.5		 6brdC-1uxiA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v0f ENDO-ALPHA-SIALIDASE

(Enterobacteria
phage K1F) 		PF12217
(End_beta_propel)
PF12218
(End_N_terminal)
PF12219
(End_tail_spike) 		5 VAL A 473
VAL A 457
GLY A 431
THR A 465
GLY A 466
 VAL  A 473 ( 0.6A)
VAL  A 457 ( 0.6A)
GLY  A 431 ( 0.0A)
THR  A 465 ( 0.9A)
GLY  A 466 ( 0.0A)
 1.08A 6brdC-1v0fA:
undetectable		 6brdC-1v0fA:
7.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ywq NITROREDUCTASE
FAMILY PROTEIN

(Bacillus cereus) 		PF00881
(Nitroreductase) 		5 VAL A  55
VAL A  98
GLY A 144
THR A  22
GLY A  94
 None
 1.03A 6brdC-1ywqA:
undetectable		 6brdC-1ywqA:
18.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c3d 2-OXOPROPYL-COM
REDUCTASE

(Xanthobacter
autotrophicus) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 VAL A 126
VAL A 206
GLY A 311
VAL A 220
GLY A 198
 None
 1.04A 6brdC-2c3dA:
8.4		 6brdC-2c3dA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c7b CARBOXYLESTERASE

(uncultured
archaeon) 		PF07859
(Abhydrolase_3) 		5 VAL A 162
VAL A 124
GLY A 215
MET A 187
GLY A  81
 None
 1.09A 6brdC-2c7bA:
undetectable		 6brdC-2c7bA:
15.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2drw D-AMINO ACID AMIDASE

(Ochrobactrum
anthropi) 		PF00144
(Beta-lactamase) 		5 VAL A 347
GLY A 243
PHE A 194
THR A 231
GLY A 202
 None
 1.20A 6brdC-2drwA:
undetectable		 6brdC-2drwA:
13.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fp7 GENOME POLYPROTEIN

(West Nile virus) 		PF00949
(Peptidase_S7) 		5 VAL B  22
VAL B  40
MET B  97
THR B 132
GLY B 133
 None
 1.09A 6brdC-2fp7B:
undetectable		 6brdC-2fp7B:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ggv NON-STRUCTURAL
PROTEIN 3

(West Nile virus) 		PF00949
(Peptidase_S7) 		5 VAL B  22
VAL B  40
MET B  97
THR B 132
GLY B 133
 None
 1.10A 6brdC-2ggvB:
undetectable		 6brdC-2ggvB:
16.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h88 SUCCINATE
DEHYDROGENASE
FLAVOPROTEIN SUBUNIT

(Gallus gallus) 		PF00890
(FAD_binding_2)
PF02910
(Succ_DH_flav_C) 		5 VAL A 363
VAL A 250
PHE A 177
THR A 213
GLY A 214
 None
None
FAD  A1001 ( 3.7A)
FAD  A1001 (-4.3A)
FAD  A1001 ( 3.7A)
 0.81A 6brdC-2h88A:
10.1		 6brdC-2h88A:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		5 VAL A 360
VAL A 387
GLY A 382
VAL A 380
GLY A 257
 None
 1.09A 6brdC-2jgdA:
undetectable		 6brdC-2jgdA:
6.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qc3 MALONYL COA-ACYL
CARRIER PROTEIN
TRANSACYLASE

(Mycobacterium
tuberculosis) 		PF00698
(Acyl_transf_1) 		5 VAL A 184
VAL A 134
PRO A 128
THR A 129
GLY A 130
 None
 1.11A 6brdC-2qc3A:
undetectable		 6brdC-2qc3A:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v40 ADENYLOSUCCINATE
SYNTHETASE ISOZYME 2

(Homo sapiens) 		PF00709
(Adenylsucc_synt) 		5 VAL A 293
VAL A 290
GLY A  98
VAL A  99
PRO A  83
 None
 1.16A 6brdC-2v40A:
undetectable		 6brdC-2v40A:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xf2 CATALASE

(Penicillium
janthinellum) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		5 VAL A 296
VAL A 301
VAL A 336
PHE A 132
GLY A 273
 None
 1.09A 6brdC-2xf2A:
undetectable		 6brdC-2xf2A:
10.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xzi EXTRACELLULAR
SIALIDASE/NEURAMINID
ASE, PUTATIVE

(Aspergillus
fumigatus) 		PF13088
(BNR_2) 		5 ARG A 230
GLY A 229
VAL A 219
THR A 278
GLY A 281
 NO2  A 505 (-3.1A)
None
None
GOL  A 503 (-4.1A)
None
 1.14A 6brdC-2xziA:
undetectable		 6brdC-2xziA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK

([Ruminococcus]
gnavus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		5 VAL A 319
VAL A 123
GLY A 248
VAL A 232
PHE A 217
 None
 1.16A 6brdC-2yfnA:
undetectable		 6brdC-2yfnA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cbo HISTONE-LYSINE
N-METHYLTRANSFERASE
SETD7

(Homo sapiens) 		PF00856
(SET) 		5 GLY A 127
VAL A 147
PHE A 182
PRO A 180
GLY A 178
 None
 1.11A 6brdC-3cboA:
undetectable		 6brdC-3cboA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cea MYO-INOSITOL
2-DEHYDROGENASE

(Lactobacillus
plantarum) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		5 VAL A 183
MET A 130
ARG A 131
PRO A 162
GLY A 242
 None
NAD  A 400 ( 3.3A)
None
None
None
 1.05A 6brdC-3ceaA:
undetectable		 6brdC-3ceaA:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d6e BETA-GLUCANASE

(Bacillus
licheniformis) 		PF00722
(Glyco_hydro_16) 		5 GLY A  50
MET A 168
VAL A  26
THR A  15
GLY A  16
 None
 1.02A 6brdC-3d6eA:
undetectable		 6brdC-3d6eA:
19.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dte IRRE PROTEIN

(Deinococcus
deserti) 		PF06114
(Peptidase_M78) 		5 VAL A 194
MET A 243
PRO A 139
THR A 140
GLY A 141
 None
 1.18A 6brdC-3dteA:
undetectable		 6brdC-3dteA:
12.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f0h AMINOTRANSFERASE

([Eubacterium]
rectale) 		PF00266
(Aminotran_5) 		5 VAL A 291
VAL A   6
MET A  65
ARG A  90
GLY A 320
 None
None
LLP  A 187 ( 3.8A)
LLP  A 187 ( 4.7A)
UNL  A 358 (-3.8A)
 1.09A 6brdC-3f0hA:
undetectable		 6brdC-3f0hA:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fn9 PUTATIVE
BETA-GALACTOSIDASE

(Bacteroides
fragilis) 		PF00703
(Glyco_hydro_2)
PF02836
(Glyco_hydro_2_C)
PF02837
(Glyco_hydro_2_N) 		5 VAL A 186
GLY A 104
VAL A 105
THR A 120
GLY A 119
 None
 1.03A 6brdC-3fn9A:
undetectable		 6brdC-3fn9A:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3heb RESPONSE REGULATOR
RECEIVER DOMAIN
PROTEIN (CHEY)

(Rhodospirillum
rubrum) 		PF00072
(Response_reg) 		5 VAL A  95
VAL A  66
GLY A  56
THR A  43
GLY A  42
 None
 1.14A 6brdC-3hebA:
undetectable		 6brdC-3hebA:
20.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hid ADENYLOSUCCINATE
SYNTHETASE

(Yersinia pestis) 		PF00709
(Adenylsucc_synt) 		5 VAL A 263
VAL A 260
GLY A  72
VAL A  73
PRO A  57
 None
 1.08A 6brdC-3hidA:
undetectable		 6brdC-3hidA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihv SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 VAL A 184
VAL A 160
MET A  58
VAL A  49
THR A 166
 None
 1.17A 6brdC-3ihvA:
undetectable		 6brdC-3ihvA:
11.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k8z NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 GLY A 136
VAL A 138
PHE A 181
PRO A 152
GLY A  81
 None
 1.20A 6brdC-3k8zA:
undetectable		 6brdC-3k8zA:
11.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k92 NAD-SPECIFIC
GLUTAMATE
DEHYDROGENASE

(Bacillus
subtilis) 		PF00208
(ELFV_dehydrog)
PF02812
(ELFV_dehydrog_N) 		5 GLY A 137
VAL A 139
PHE A 182
PRO A 153
GLY A  82
 None
 1.19A 6brdC-3k92A:
undetectable		 6brdC-3k92A:
12.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kv1 TRANSCRIPTIONAL
REPRESSOR

(Aliivibrio
fischeri) 		PF04198
(Sugar-bind) 		5 VAL A 221
GLY A 209
ARG A 204
VAL A 207
GLY A 154
 None
None
None
None
GOL  A 271 ( 3.8A)
 1.13A 6brdC-3kv1A:
undetectable		 6brdC-3kv1A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kv1 TRANSCRIPTIONAL
REPRESSOR

(Aliivibrio
fischeri) 		PF04198
(Sugar-bind) 		5 VAL A 242
VAL A 221
GLY A 209
VAL A 207
GLY A 154
 None
None
None
None
GOL  A 271 ( 3.8A)
 0.99A 6brdC-3kv1A:
undetectable		 6brdC-3kv1A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lvu ABC TRANSPORTER,
PERIPLASMIC
SUBSTRATE-BINDING
PROTEIN

(Ruegeria
pomeroyi) 		PF00496
(SBP_bac_5) 		5 MET A 315
ARG A 333
PRO A 389
THR A 392
GLY A 391
 None
 1.04A 6brdC-3lvuA:
undetectable		 6brdC-3lvuA:
20.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mca ELONGATION FACTOR 1
ALPHA-LIKE PROTEIN

(Schizosaccharomyces
pombe) 		PF00009
(GTP_EFTU)
PF03143
(GTP_EFTU_D3) 		5 VAL A 286
VAL A 181
GLY A 301
PHE A 293
GLY A 189
 None
 1.06A 6brdC-3mcaA:
undetectable		 6brdC-3mcaA:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mmp ELONGATION FACTOR TU
2, ELONGATION FACTOR
TS
RNA-DIRECTED RNA
POLYMERASE BETA
CHAIN

(Escherichia
coli;
Escherichia
virus Qbeta) 		PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
no annotation 		5 VAL A 234
GLY A1317
VAL A1383
PRO A1328
GLY G 486
 None
 1.08A 6brdC-3mmpA:
undetectable		 6brdC-3mmpA:
8.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pnr FALCIPAIN 2
PBICP-C

(Plasmodium
berghei;
Plasmodium
falciparum) 		PF00112
(Peptidase_C1)
PF09394
(Inhibitor_I42)
PF12628
(Inhibitor_I71) 		5 VAL A 150
VAL A 152
ARG B 336
GLY A 207
GLY A  40
 None
 1.08A 6brdC-3pnrA:
undetectable		 6brdC-3pnrA:
15.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ram HMRA PROTEIN

(Staphylococcus
aureus) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 VAL A 320
VAL A 141
GLY A 130
THR A  62
GLY A  63
 None
None
GOL  A 516 (-3.2A)
None
None
 1.19A 6brdC-3ramA:
undetectable		 6brdC-3ramA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpb RABPHILIN 3-A

(Rattus
norvegicus) 		PF00168
(C2) 		5 GLY A 642
VAL A 629
PHE A 607
PRO A 605
THR A 602
 None
 1.18A 6brdC-3rpbA:
undetectable		 6brdC-3rpbA:
17.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rrv ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		5 VAL A 107
VAL A 119
GLY A 168
ARG A 170
GLY A  66
 None
 1.00A 6brdC-3rrvA:
undetectable		 6brdC-3rrvA:
14.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s47 MANDELATE
RACEMASE/MUCONATE
LACTONIZING PROTEIN

(Clostridium
beijerinckii) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 VAL A  53
GLY A 318
VAL A 321
PHE A 115
THR A 290
 None
 1.20A 6brdC-3s47A:
undetectable		 6brdC-3s47A:
12.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3svt SHORT-CHAIN TYPE
DEHYDROGENASE/REDUCT
ASE

(Mycobacterium
ulcerans) 		PF13561
(adh_short_C2) 		5 VAL A  81
VAL A  78
MET A 171
GLY A 144
GLY A  38
 None
None
None
None
CL  A 279 ( 3.9A)
 1.08A 6brdC-3svtA:
3.9		 6brdC-3svtA:
17.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tu6 PSEUDOAZURIN (BLUE
COPPER PROTEIN)

(Sinorhizobium
meliloti) 		PF00127
(Copper-bind) 		5 VAL A  33
GLY A  50
VAL A 103
PRO A  97
GLY A  95
 None
 1.12A 6brdC-3tu6A:
undetectable		 6brdC-3tu6A:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uxm THYMIDYLATE KINASE

(Pseudomonas
aeruginosa) 		PF02223
(Thymidylate_kin) 		5 VAL A  91
VAL A   6
GLY A 196
ARG A  26
THR A  18
 None
 0.94A 6brdC-3uxmA:
undetectable		 6brdC-3uxmA:
21.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vmw PECTATE LYASE

(Bacillus sp.
N16-5) 		PF00544
(Pec_lyase_C) 		5 VAL A 181
MET A 218
PHE A 284
PRO A 264
GLY A 266
 None
 1.15A 6brdC-3vmwA:
undetectable		 6brdC-3vmwA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wgc L-ALLO-THREONINE
ALDOLASE

(Aeromonas
jandaei) 		PF01212
(Beta_elim_lyase) 		5 VAL A  38
GLY A 227
VAL A 226
THR A  61
GLY A  60
 None
None
None
PLG  A 401 (-3.8A)
PLG  A 401 (-3.2A)
 1.17A 6brdC-3wgcA:
undetectable		 6brdC-3wgcA:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whi SUBTILISIN E

(Bacillus
subtilis) 		PF00082
(Peptidase_S8)
PF05922
(Inhibitor_I9) 		5 VAL A  44
VAL A 228
GLY A 192
THR A 220
GLY A 221
 None
 1.09A 6brdC-3whiA:
undetectable		 6brdC-3whiA:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvr PGM1

(Streptomyces
cirratus) 		no annotation 5 VAL A   5
VAL A  38
GLY A  70
THR A  20
GLY A  21
 None
None
None
SO4  A 501 (-3.3A)
SO4  A 501 (-4.0A)
 1.19A 6brdC-3wvrA:
undetectable		 6brdC-3wvrA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x0v L-LYSINE OXIDASE

(Trichoderma
viride) 		PF01593
(Amino_oxidase) 		5 VAL A 364
GLY A  65
MET A  67
ARG A  68
THR A 370
 None
FAD  A 601 (-4.1A)
None
EPE  A 602 ( 3.1A)
None
 1.16A 6brdC-3x0vA:
2.2		 6brdC-3x0vA:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ap8 MOLYBDOPTERIN
SYNTHASE CATALYTIC
SUBUNIT

(Homo sapiens) 		PF02391
(MoaE) 		5 VAL A 103
VAL A 162
GLY A 126
THR A  77
GLY A  76
 None
 1.18A 6brdC-4ap8A:
1.0		 6brdC-4ap8A:
23.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cgt CYCLODEXTRIN
GLYCOSYLTRANSFERASE

(Bacillus
circulans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG)
PF02806
(Alpha-amylase_C) 		5 VAL A 231
GLY A 225
VAL A 223
PHE A 118
PRO A  79
 None
 1.09A 6brdC-4cgtA:
undetectable		 6brdC-4cgtA:
7.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fei HEAT SHOCK
PROTEIN-RELATED
PROTEIN

(Deinococcus
radiodurans) 		PF00011
(HSP20) 		5 GLY A 130
VAL A  69
PHE A 108
THR A  76
GLY A  75
 None
 1.14A 6brdC-4feiA:
undetectable		 6brdC-4feiA:
25.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fq7 MALEATE CIS-TRANS
ISOMERASE

(Pseudomonas
putida) 		no annotation 5 VAL A 135
VAL A 158
GLY A  92
MET A  87
GLY A 124
 None
 1.12A 6brdC-4fq7A:
undetectable		 6brdC-4fq7A:
15.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwt ELONGATION FACTOR
TS, ELONGATION
FACTOR TU, LINKER, Q
BETA REPLICASE

(Escherichia
coli;
Escherichia
virus Qbeta) 		PF00009
(GTP_EFTU)
PF00889
(EF_TS)
PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2)
PF03431
(RNA_replicase_B) 		5 VAL A 235
GLY A 602
VAL A 668
PRO A 613
GLY A1180
 None
 1.11A 6brdC-4fwtA:
undetectable		 6brdC-4fwtA:
4.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gj1 1-(5-PHOSPHORIBOSYL)
-5-[(5-PHOSPHORIBOSY
LAMINO)METHYLIDENEAM
INO]
IMIDAZOLE-4-CARBOXAM
IDE ISOMERASE

(Campylobacter
jejuni) 		PF00977
(His_biosynth) 		5 VAL A 127
VAL A 102
GLY A 203
VAL A 205
PHE A 232
 None
 1.04A 6brdC-4gj1A:
undetectable		 6brdC-4gj1A:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hiz ENDOSIALIDASE

(Enterobacteria
phage phi92) 		PF12217
(End_beta_propel)
PF12218
(End_N_terminal)
PF12219
(End_tail_spike) 		5 VAL A 305
VAL A 289
GLY A 263
THR A 297
GLY A 298
 None
None
None
SLB  A 801 ( 4.5A)
SLB  A 801 (-3.5A)
 1.05A 6brdC-4hizA:
undetectable		 6brdC-4hizA:
7.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hiz ENDOSIALIDASE

(Enterobacteria
phage phi92) 		PF12217
(End_beta_propel)
PF12218
(End_N_terminal)
PF12219
(End_tail_spike) 		5 VAL A 305
VAL A 289
GLY A 264
THR A 297
GLY A 298
 None
None
None
SLB  A 801 ( 4.5A)
SLB  A 801 (-3.5A)
 1.17A 6brdC-4hizA:
undetectable		 6brdC-4hizA:
7.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i9y E3 SUMO-PROTEIN
LIGASE RANBP2

(Homo sapiens) 		PF00160
(Pro_isomerase) 		5 VAL A  61
VAL A 113
GLY A 104
THR A  73
GLY A  72
 GOL  A 201 ( 4.9A)
GOL  A 201 ( 4.2A)
None
None
None
 1.10A 6brdC-4i9yA:
undetectable		 6brdC-4i9yA:
18.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcl CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Paenibacillus
macerans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		5 VAL A 231
GLY A 225
VAL A 223
PHE A 118
PRO A  79
 None
 0.93A 6brdC-4jclA:
undetectable		 6brdC-4jclA:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jcl CYCLOMALTODEXTRIN
GLUCANOTRANSFERASE

(Paenibacillus
macerans) 		PF00128
(Alpha-amylase)
PF00686
(CBM_20)
PF01833
(TIG) 		5 VAL A 231
GLY A 225
VAL A 223
PHE A 118
PRO A  79
 None
 1.19A 6brdC-4jclA:
undetectable		 6brdC-4jclA:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jnc BIFUNCTIONAL EPOXIDE
HYDROLASE 2

(Homo sapiens) 		PF00561
(Abhydrolase_1) 		5 VAL A 261
VAL A 330
GLY A 517
THR A 360
GLY A 338
 None
None
None
1LF  A 601 ( 4.0A)
None
 1.08A 6brdC-4jncA:
undetectable		 6brdC-4jncA:
13.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k7g 3-HYDROXYPROLINE
DEHYDRATSE

(Agrobacterium
vitis) 		PF05544
(Pro_racemase) 		5 VAL B 127
GLY B  19
PRO B 255
THR B 256
GLY B 257
 None
None
None
PYC  B 904 (-4.3A)
PYC  B 904 (-3.7A)
 1.12A 6brdC-4k7gB:
undetectable		 6brdC-4k7gB:
16.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ons CATENIN ALPHA-2
CATENIN BETA-1

(Mus musculus) 		PF01044
(Vinculin)
no annotation 		5 VAL A  35
VAL B 137
GLY A 100
THR A 122
GLY A 121
 None
 1.06A 6brdC-4onsA:
undetectable		 6brdC-4onsA:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p6v NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT C
NA(+)-TRANSLOCATING
NADH-QUINONE
REDUCTASE SUBUNIT D

(Vibrio cholerae) 		PF02508
(Rnf-Nqr)
PF04205
(FMN_bind) 		5 ARG D 152
PHE D 104
PRO C 174
THR C 173
GLY C 177
 None
None
None
FMN  C 301 (-3.2A)
FMN  C 301 ( 3.8A)
 1.17A 6brdC-4p6vD:
undetectable		 6brdC-4p6vD:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pdh TRAP DICARBOXYLATE
TRANSPORTER, DCTP
SUBUNIT

(Polaromonas sp.
JS666) 		PF03480
(DctP) 		5 VAL A 281
MET A 181
GLY A 102
VAL A 104
PHE A 142
 None
EAX  A 401 (-3.3A)
None
None
None
 1.08A 6brdC-4pdhA:
undetectable		 6brdC-4pdhA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uwq SULFUR OXIDATION
PROTEIN SOXB

(Thermus
thermophilus) 		PF02872
(5_nucleotid_C) 		5 VAL A 166
VAL A 168
GLY A 316
PHE A  57
GLY A  50
 None
 1.18A 6brdC-4uwqA:
undetectable		 6brdC-4uwqA:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xf5 TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL

(Chromohalobacter
salexigens) 		PF03480
(DctP) 		5 VAL A 144
GLY A  80
MET A 101
THR A  90
GLY A  89
 None
 0.94A 6brdC-4xf5A:
undetectable		 6brdC-4xf5A:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xg1 DIAMINOPIMELATE
DECARBOXYLASE

(Psychromonas
ingrahamii) 		PF00278
(Orn_DAP_Arg_deC)
PF02784
(Orn_Arg_deC_N) 		5 VAL A 369
VAL A 287
VAL A  68
THR A 379
GLY A 377
 None
 1.20A 6brdC-4xg1A:
undetectable		 6brdC-4xg1A:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zj8 HUMAN OX1R FUSION
PROTEIN TO P.ABYSII
GLYCOGEN SYNTHASE

(Homo sapiens;
Pyrococcus
abyssi) 		PF00001
(7tm_1)
PF00534
(Glycos_transf_1) 		5 VAL A1105
GLY A1047
ARG A1040
PRO A1123
GLY A1125
 None
 1.20A 6brdC-4zj8A:
undetectable		 6brdC-4zj8A:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5all SOLUBLE EPOXIDE
HYDROLASE

(Homo sapiens) 		PF00561
(Abhydrolase_1)
PF13419
(HAD_2) 		5 VAL A 261
VAL A 330
GLY A 517
THR A 360
GLY A 338
 None
None
None
SO4  A1550 ( 4.0A)
None
 1.09A 6brdC-5allA:
undetectable		 6brdC-5allA:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fya PATATIN-LIKE
PROTEIN, PLPD

(Pseudomonas
aeruginosa) 		PF01734
(Patatin) 		5 VAL A 175
VAL A 164
GLY A  26
MET A 222
GLY A  67
 None
 1.20A 6brdC-5fyaA:
undetectable		 6brdC-5fyaA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gxf ACRYLYL-COA
REDUCTASE ACUI

(Ruegeria
pomeroyi) 		PF00107
(ADH_zinc_N) 		5 VAL A  63
GLY A  70
VAL A  86
THR A  89
GLY A  90
 None
 1.17A 6brdC-5gxfA:
undetectable		 6brdC-5gxfA:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i1w CRMK

(Actinoalloteichus
sp. WH1-2216-6) 		PF01565
(FAD_binding_4)
PF08031
(BBE) 		5 VAL A  70
GLY A 126
VAL A 104
PHE A 119
GLY A 135
 FAD  A 601 (-4.5A)
None
None
None
None
 1.19A 6brdC-5i1wA:
undetectable		 6brdC-5i1wA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i4q ELONGATION FACTOR TU

(Escherichia
coli) 		PF03143
(GTP_EFTU_D3)
PF03144
(GTP_EFTU_D2) 		5 VAL C 392
VAL C 389
GLY C 290
THR C 339
GLY C 340
 None
 0.95A 6brdC-5i4qC:
undetectable		 6brdC-5i4qC:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ixm LPS-ASSEMBLY
LIPOPROTEIN LPTE

(Yersinia pestis) 		PF04390
(LptE) 		5 VAL B 100
VAL B  84
VAL B  41
PRO B  53
THR B  54
 None
 1.06A 6brdC-5ixmB:
undetectable		 6brdC-5ixmB:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5l3r CELL DIVISION
PROTEIN FTSY
HOMOLOG,
CHLOROPLASTIC
SIGNAL RECOGNITION
PARTICLE 54 KDA
PROTEIN,
CHLOROPLASTIC

(Arabidopsis
thaliana) 		PF00448
(SRP54)
PF02881
(SRP54_N) 		5 VAL B 332
VAL B 329
GLY B 175
THR A 300
GLY A 301
 None
None
GCP  B 401 (-4.1A)
None
None
 1.14A 6brdC-5l3rB:
undetectable		 6brdC-5l3rB:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5umu FACT COMPLEX SUBUNIT
SPT16

(Homo sapiens) 		no annotation 5 VAL A 868
VAL A 860
GLY A 896
ARG A 847
VAL A 848
 None
None
FMT  A1011 ( 4.3A)
None
None
 1.16A 6brdC-5umuA:
undetectable		 6brdC-5umuA:
24.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v8c TRANSCRIPTIONAL
REGULATOR

(Actinomyces
oris) 		no annotation 5 VAL A 135
MET A  88
VAL A  84
THR A 105
GLY A 104
 None
 1.15A 6brdC-5v8cA:
undetectable		 6brdC-5v8cA:
26.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9u THERMOSOME, ALPHA
SUBUNIT

(Carboxydothermus
hydrogenoformans) 		no annotation 5 VAL A 474
GLY A  39
MET A 430
THR A  89
GLY A  88
 ADP  A 601 (-4.7A)
None
ADP  A 601 (-4.1A)
ADP  A 601 (-4.5A)
ADP  A 601 (-3.2A)
 1.04A 6brdC-5x9uA:
undetectable		 6brdC-5x9uA:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnr ALYQ

(Persicobacter
sp. CCB-QB2) 		no annotation 5 VAL A 569
VAL A 416
GLY A 439
THR A 411
GLY A 412
 None
 1.13A 6brdC-5xnrA:
undetectable		 6brdC-5xnrA:
24.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5y5s PHOTOSYNTHETIC
REACTION CENTER H
SUBUNIT

(Thermochromatium
tepidum) 		no annotation 5 VAL H 184
VAL H 193
MET H 107
GLY H 246
GLY H 198
 None
 1.03A 6brdC-5y5sH:
undetectable		 6brdC-5y5sH:
19.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bo6 -

(-) 		no annotation 5 VAL A 132
VAL A  90
GLY A  17
PRO A 314
GLY A 316
 None
 1.15A 6brdC-6bo6A:
undetectable		 6brdC-6bo6A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c0d AMIDASE,
HYDANTOINASE/CARBAMO
YLASE FAMILY

(Paraburkholderia
phymatum) 		no annotation 5 VAL A 363
ARG A  43
GLY A  63
THR A 129
GLY A 128
 None
 1.18A 6brdC-6c0dA:
2.5		 6brdC-6c0dA:
26.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6c7s PUTATIVE RIFAMPIN
MONOOXYGENASE

(Nocardia
farcinica) 		no annotation 7 VAL A  71
ARG A 196
GLY A 203
PHE A 256
PRO A 283
THR A 284
GLY A 285
 None
RFH  A 502 (-3.1A)
RFH  A 502 (-3.6A)
RFH  A 502 (-4.4A)
RFH  A 502 ( 4.2A)
RFH  A 502 (-4.0A)
RFH  A 502 (-3.4A)
 0.90A 6brdC-6c7sA:
58.2		 6brdC-6c7sA:
74.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6c7s PUTATIVE RIFAMPIN
MONOOXYGENASE

(Nocardia
farcinica) 		no annotation 6 VAL A  71
GLY A 203
PHE A 256
PRO A 283
THR A 284
GLY A 285
 None
RFH  A 502 (-3.6A)
RFH  A 502 (-4.4A)
RFH  A 502 ( 4.2A)
RFH  A 502 (-4.0A)
RFH  A 502 (-3.4A)
 1.23A 6brdC-6c7sA:
58.2		 6brdC-6c7sA:
74.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6c7s PUTATIVE RIFAMPIN
MONOOXYGENASE

(Nocardia
farcinica) 		no annotation 6 VAL A  71
GLY A 203
PHE A 256
PRO A 283
THR A 284
GLY A 286
 None
RFH  A 502 (-3.6A)
RFH  A 502 (-4.4A)
RFH  A 502 ( 4.2A)
RFH  A 502 (-4.0A)
FAD  A 501 ( 3.3A)
 1.37A 6brdC-6c7sA:
58.2		 6brdC-6c7sA:
74.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6dcl HETEROGENEOUS
NUCLEAR
RIBONUCLEOPROTEIN A1

(Homo sapiens) 		no annotation 5 GLY A 110
VAL A 109
PHE A 125
THR A 169
GLY A 172
 U  D   8 ( 3.4A)
None
None
None
None
 1.16A 6brdC-6dclA:
undetectable		 6brdC-6dclA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fyd PUTATIVE
FAD-DEPENDENT
OXYGENASE ENCM

(Streptomyces
maritimus) 		no annotation 5 VAL A 139
GLY A 195
VAL A 191
THR A 202
GLY A 113
 FAD  A 600 (-4.4A)
None
None
None
FAD  A 600 (-3.8A)
 1.17A 6brdC-6fydA:
0.9		 6brdC-6fydA:
17.07