SIMILAR PATTERNS OF AMINO ACIDS FOR 6BRD_B_RFPB502_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2o CHEB METHYLESTERASE

(Salmonella
enterica)
PF00072
(Response_reg)
PF01339
(CheB_methylest)
5 GLY A 230
PHE A 104
THR A 168
GLY A 167
GLY A 166
None
1.12A 6brdB-1a2oA:
undetectable
6brdB-1a2oA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bdg HEXOKINASE

(Schistosoma
mansoni)
PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2)
5 GLY A 179
VAL A 180
PHE A 154
THR A 172
GLY A 174
None
None
None
GLC  A 501 (-2.7A)
None
1.21A 6brdB-1bdgA:
0.0
6brdB-1bdgA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dab P.69 PERTACTIN

(Bordetella
pertussis)
PF03212
(Pertactin)
5 HIS A 150
GLY A 243
VAL A 240
GLY A 127
GLY A 147
None
1.22A 6brdB-1dabA:
undetectable
6brdB-1dabA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e9y UREASE SUBUNIT BETA

(Helicobacter
pylori)
PF00449
(Urease_alpha)
PF01979
(Amidohydro_1)
5 PHE B 195
VAL B 369
THR B 171
GLY B 159
GLY B 160
None
None
KCX  B 219 ( 3.0A)
None
None
1.01A 6brdB-1e9yB:
undetectable
6brdB-1e9yB:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eww ANTIFREEZE PROTEIN

(Choristoneura
fumiferana)
PF05264
(CfAFP)
5 GLY A  44
VAL A  45
THR A  53
GLY A  54
GLY A  71
None
1.04A 6brdB-1ewwA:
undetectable
6brdB-1ewwA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3n 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE II


(Thermus
thermophilus)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 GLY A   8
VAL A   6
PHE A 405
GLY A 164
GLY A 344
None
1.21A 6brdB-1j3nA:
0.0
6brdB-1j3nA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jkm BREFELDIN A ESTERASE

(Bacillus
subtilis)
PF07859
(Abhydrolase_3)
5 PHE A  40
GLY A 339
VAL A 337
PHE A  29
GLY A  41
None
1.06A 6brdB-1jkmA:
0.8
6brdB-1jkmA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA


(Paracoccus
denitrificans)
PF00115
(COX1)
5 HIS A 411
GLY A 286
THR A 384
GLY A 387
GLY A 386
HEA  A 602 (-3.4A)
None
HEA  A 602 ( 4.7A)
HEA  A 602 (-3.3A)
None
1.22A 6brdB-1qleA:
0.0
6brdB-1qleA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA


(Paracoccus
denitrificans)
PF00115
(COX1)
5 HIS A 411
GLY A 423
THR A 384
GLY A 387
GLY A 386
HEA  A 602 (-3.4A)
None
HEA  A 602 ( 4.7A)
HEA  A 602 (-3.3A)
None
1.16A 6brdB-1qleA:
0.0
6brdB-1qleA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w18 LEVANSUCRASE

(Gluconacetobacter
diazotrophicus)
PF02435
(Glyco_hydro_68)
5 PHE A 180
VAL A 240
PHE A 282
GLY A 200
GLY A 201
None
1.11A 6brdB-1w18A:
undetectable
6brdB-1w18A:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE


(Agrobacterium
tumefaciens)
PF04095
(NAPRTase)
5 PHE A 429
VAL A 305
PHE A 311
THR A 294
GLY A 293
None
1.06A 6brdB-1ybeA:
undetectable
6brdB-1ybeA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr2 PROLYL
OLIGOPEPTIDASE


(Novosphingobium
capsulatum)
PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N)
5 PHE A 498
GLY A 582
VAL A 584
GLY A 497
GLY A 527
None
1.19A 6brdB-1yr2A:
undetectable
6brdB-1yr2A:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzy HYPOTHETICAL PROTEIN
HI1011


(Haemophilus
influenzae)
PF07005
(DUF1537)
PF17042
(DUF1357_C)
5 GLY A  90
ARG A  50
THR A 217
GLY A 218
GLY A 219
None
1.14A 6brdB-1yzyA:
undetectable
6brdB-1yzyA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cmt PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
E


(Schistosoma
mansoni)
PF00160
(Pro_isomerase)
5 GLY A 103
VAL A 139
GLY A  71
GLY A  72
MET A 149
None
0.93A 6brdB-2cmtA:
undetectable
6brdB-2cmtA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E


(Methanothermobacter
thermautotrophicus)
PF02637
(GatB_Yqey)
PF02934
(GatB_N)
PF02938
(GAD)
5 GLY C 170
VAL C 171
THR C 127
GLY C 128
GLY C 129
None
1.05A 6brdB-2d6fC:
0.9
6brdB-2d6fC:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eij CYTOCHROME C OXIDASE
SUBUNIT 1


(Bos taurus)
PF00115
(COX1)
5 HIS A 376
GLY A 250
THR A 349
GLY A 352
GLY A 351
HEA  A 516 (-3.3A)
None
HEA  A 516 ( 4.2A)
HEA  A 516 (-3.5A)
None
1.10A 6brdB-2eijA:
undetectable
6brdB-2eijA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fel 3-CARBOXY-CIS,CIS-MU
CONATE LACTONIZING
ENZYME


(Agrobacterium
tumefaciens)
PF00206
(Lyase_1)
5 GLY A 314
ARG A 231
THR A 107
GLY A 196
GLY A 195
None
1.21A 6brdB-2felA:
undetectable
6brdB-2felA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdu SUCROSE
PHOSPHORYLASE


(Bifidobacterium
adolescentis)
PF00128
(Alpha-amylase)
PF09244
(DUF1964)
5 HIS A 234
PHE A 253
ARG A 365
GLY A 381
GLY A 293
SUC  A2064 (-3.9A)
None
None
None
None
1.09A 6brdB-2gduA:
undetectable
6brdB-2gduA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hyk BETA-1,3-GLUCANASE

(Nocardiopsis
sp. F96)
PF00722
(Glyco_hydro_16)
5 HIS A 142
ARG A 132
GLY A 222
GLY A 149
GLY A 148
GOL  A 249 ( 4.1A)
None
None
None
GOL  A 250 ( 3.4A)
0.99A 6brdB-2hykA:
undetectable
6brdB-2hykA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzt HEXOKINASE-2

(Homo sapiens)
PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2)
5 GLY A 179
VAL A 180
PHE A 154
THR A 172
GLY A 174
None
None
None
GLC  A1001 (-2.7A)
None
1.12A 6brdB-2nztA:
undetectable
6brdB-2nztA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ood BLR3880 PROTEIN

(Bradyrhizobium
diazoefficiens)
PF01979
(Amidohydro_1)
5 GLY A 330
VAL A 327
PHE A 123
THR A 132
GLY A 131
None
1.17A 6brdB-2oodA:
undetectable
6brdB-2oodA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qm1 GLUCOKINASE

(Enterococcus
faecalis)
PF00480
(ROK)
5 GLY A 192
VAL A 193
PHE A 226
GLY A 267
GLY A 266
None
1.20A 6brdB-2qm1A:
undetectable
6brdB-2qm1A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qne PUTATIVE
METHYLTRANSFERASE


(Desulfitobacterium
hafniense)
PF06253
(MTTB)
5 GLY A 132
PHE A 361
THR A 346
GLY A 312
GLY A 313
EDO  A 477 (-3.2A)
None
None
None
None
1.11A 6brdB-2qneA:
undetectable
6brdB-2qneA:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA


(Desulfovibrio
vulgaris)
PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr)
5 GLY B 138
ARG B  98
VAL B 139
GLY B 286
GLY B 287
None
SH0  A 503 (-3.9A)
None
None
None
0.98A 6brdB-2v4jB:
undetectable
6brdB-2v4jB:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9y PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE


(Homo sapiens)
PF00586
(AIRS)
PF02769
(AIRS_C)
5 GLY A 618
THR A 682
GLY A 683
GLY A 684
MET A 519
None
1.04A 6brdB-2v9yA:
undetectable
6brdB-2v9yA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2woc ADP-RIBOSYL-[DINITRO
GEN REDUCTASE]
GLYCOHYDROLASE


(Rhodospirillum
rubrum)
PF03747
(ADP_ribosyl_GH)
5 GLY A 248
VAL A 238
THR A  46
GLY A  47
GLY A  48
None
1.06A 6brdB-2wocA:
undetectable
6brdB-2wocA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xn1 ALPHA-GALACTOSIDASE

(Lactobacillus
acidophilus)
PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N)
5 HIS A 203
ARG A 377
GLY A 372
GLY A 532
GLY A 533
GOL  A1734 ( 4.4A)
None
None
GOL  A1734 ( 3.3A)
TRS  A1733 (-4.4A)
1.17A 6brdB-2xn1A:
undetectable
6brdB-2xn1A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt0 HALOALKANE
DEHALOGENASE


(Plesiocystis
pacifica)
PF00561
(Abhydrolase_1)
5 MET A  65
VAL A 280
GLY A 126
GLY A 125
MET A 257
None
0.98A 6brdB-2xt0A:
undetectable
6brdB-2xt0A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9x LECTIN-LIKE FOLD
PROTEIN
POLYPHENOL OXIDASE


(Agaricus
bisporus)
PF00264
(Tyrosinase)
no annotation
5 HIS A 251
GLY E  13
VAL E 150
THR A  87
GLY A 245
None
1.02A 6brdB-2y9xA:
undetectable
6brdB-2y9xA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK


([Ruminococcus]
gnavus)
PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N)
5 HIS A 199
ARG A 373
GLY A 368
GLY A 520
GLY A 521
None
1.18A 6brdB-2yfnA:
undetectable
6brdB-2yfnA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmb ACETOACETATE
DECARBOXYLASE


(Methanoculleus
marisnigri)
PF06314
(ADC)
5 GLY A 114
THR A   9
GLY A  19
GLY A  18
MET A 258
P33  A 269 ( 4.5A)
None
None
None
None
1.02A 6brdB-3cmbA:
undetectable
6brdB-3cmbA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cyv UROPORPHYRINOGEN
DECARBOXYLASE


(Shigella
flexneri)
PF01208
(URO-D)
5 ARG A  27
GLY A 328
THR A 249
GLY A 211
GLY A 212
None
1.21A 6brdB-3cyvA:
undetectable
6brdB-3cyvA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dl0 ADENYLATE KINASE

(Bacillus
subtilis)
PF00406
(ADK)
PF05191
(ADK_lid)
5 HIS A  28
VAL A 115
THR A  15
GLY A  14
GLY A  17
None
None
AP5  A 218 (-3.6A)
AP5  A 218 (-3.7A)
None
1.19A 6brdB-3dl0A:
undetectable
6brdB-3dl0A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8m SERINE
HYDROXYMETHYLTRANSFE
RASE


(Escherichia
coli)
PF00464
(SHMT)
5 HIS A 129
PHE A 198
VAL A 208
GLY A 172
GLY A 173
None
1.13A 6brdB-3g8mA:
undetectable
6brdB-3g8mA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ij3 CYTOSOL
AMINOPEPTIDASE


(Coxiella
burnetii)
PF00883
(Peptidase_M17)
5 HIS A 255
ARG A 341
GLY A 338
GLY A 252
GLY A 251
None
SO4  A 461 ( 3.6A)
None
None
None
1.10A 6brdB-3ij3A:
undetectable
6brdB-3ij3A:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2x UNCHARACTERIZED
PROTEIN YAGE


(Escherichia
coli)
PF00701
(DHDPS)
5 GLY A 240
VAL A 242
PHE A 208
GLY A 214
GLY A 215
None
1.15A 6brdB-3n2xA:
undetectable
6brdB-3n2xA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I


(Rhodobacter
sphaeroides)
PF00115
(COX1)
5 HIS A 419
GLY A 431
THR A 392
GLY A 395
GLY A 394
HEA  A   2 (-3.2A)
None
HEA  A   2 ( 3.9A)
HEA  A   2 (-3.4A)
None
1.08A 6brdB-3omnA:
undetectable
6brdB-3omnA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5m ENOYL-COA
HYDRATASE/ISOMERASE


(Mycobacterium
avium)
PF00378
(ECH_1)
5 PHE A 233
GLY A  62
VAL A 100
THR A 126
GLY A 129
None
1.18A 6brdB-3p5mA:
undetectable
6brdB-3p5mA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sft CHEMOTAXIS RESPONSE
REGULATOR
PROTEIN-GLUTAMATE
METHYLESTERASE


(Thermotoga
maritima)
PF01339
(CheB_methylest)
5 GLY A 290
VAL A 321
THR A 303
GLY A 302
GLY A 301
None
0.96A 6brdB-3sftA:
undetectable
6brdB-3sftA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sze SERINE PROTEASE ESPP

(Escherichia
coli)
PF02395
(Peptidase_S6)
5 GLY A 668
VAL A 648
THR A 705
GLY A 706
GLY A 707
None
1.20A 6brdB-3szeA:
undetectable
6brdB-3szeA:
6.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uma HYPOTHETICAL
PEROXIREDOXIN
PROTEIN


(Sinorhizobium
meliloti)
PF08534
(Redoxin)
5 GLY A  43
VAL A  41
PHE A  39
GLY A  91
GLY A  92
None
1.08A 6brdB-3umaA:
undetectable
6brdB-3umaA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vta CUCUMISIN

(Cucumis melo)
PF00082
(Peptidase_S8)
5 ARG A 332
GLY A 226
THR A 211
GLY A 232
GLY A 214
None
1.21A 6brdB-3vtaA:
undetectable
6brdB-3vtaA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ain GLYCINE BETAINE
TRANSPORTER BETP


(Corynebacterium
glutamicum)
PF02028
(BCCT)
6 GLY A 201
VAL A 200
PHE A 529
THR A 246
GLY A 249
MET A 479
None
1.35A 6brdB-4ainA:
undetectable
6brdB-4ainA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata)
PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s)
5 GLY B2947
PHE B3144
GLY B2938
GLY B2937
MET B3103
None
1.15A 6brdB-4bedB:
undetectable
6brdB-4bedB:
4.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhl ARGININE KINASE

(Litopenaeus
vannamei)
PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN)
5 VAL A 250
PHE A 104
THR A 277
GLY A 276
GLY A 266
None
0.99A 6brdB-4bhlA:
1.0
6brdB-4bhlA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccy CARBOXYLESTERASE
YBFK


(Bacillus
subtilis)
PF12697
(Abhydrolase_6)
5 HIS B  62
GLY B 220
PHE B 162
GLY B  64
GLY B  63
None
1.17A 6brdB-4ccyB:
undetectable
6brdB-4ccyB:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d4p PROTEIN ATS1,
DIPHTHAMIDE
BIOSYNTHESIS PROTEIN
3


(Saccharomyces
cerevisiae)
PF00415
(RCC1)
PF05207
(zf-CSL)
5 GLY A  59
VAL A  83
PHE A 118
THR A  98
GLY A 113
None
1.13A 6brdB-4d4pA:
undetectable
6brdB-4d4pA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e0t CYCLIC DIPEPTIDE
N-PRENYLTRANSFERASE


(Aspergillus
fumigatus)
PF11991
(Trp_DMAT)
5 GLY A  95
VAL A 135
THR A 108
GLY A 111
GLY A 110
None
None
EDO  A 603 (-4.6A)
None
None
1.08A 6brdB-4e0tA:
undetectable
6brdB-4e0tA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE


(Thermothelomyces
thermophila)
no annotation 5 GLY A 337
MET A 320
THR A 210
GLY A 211
GLY A 216
None
1.16A 6brdB-4g4iA:
undetectable
6brdB-4g4iA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjl NAPHTHALENE
1,2-DIOXYGENASE
SUBUNIT ALPHA


(Pseudomonas sp.
C18)
PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A)
5 HIS A 261
GLY A 178
PHE A 147
THR A 308
GLY A 311
None
1.11A 6brdB-4hjlA:
undetectable
6brdB-4hjlA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3f SERINE HYDROLASE
CCSP0084


(Cycloclasticus
sp. P1)
PF12697
(Abhydrolase_6)
5 GLY A 131
VAL A 130
THR A 201
GLY A 200
GLY A 199
None
1.22A 6brdB-4i3fA:
undetectable
6brdB-4i3fA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ip4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN


(Ruegeria sp.
TM1040)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 GLY A  69
VAL A  72
PHE A  87
GLY A 328
GLY A 327
None
1.12A 6brdB-4ip4A:
undetectable
6brdB-4ip4A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2


(Vibrio cholerae)
no annotation 5 GLY D  10
VAL D   8
PHE D 411
GLY D 167
GLY D 348
None
1.21A 6brdB-4jrmD:
undetectable
6brdB-4jrmD:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3j HEPATOCYTE GROWTH
FACTOR
HEPATOCYTE GROWTH
FACTOR BETA CHAIN


(Homo sapiens)
PF00089
(Trypsin)
PF01403
(Sema)
PF01437
(PSI)
5 HIS A 517
GLY B 225
MET B 227
ARG B 218
GLY A 618
None
1.08A 6brdB-4k3jA:
undetectable
6brdB-4k3jA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5r OXYGENASE

(Streptomyces
argillaceus)
PF01494
(FAD_binding_3)
5 HIS A  57
ARG A 225
PHE A 272
GLY A 302
MET A 357
None
None
FAD  A 601 ( 4.2A)
FAD  A 601 (-3.4A)
None
0.99A 6brdB-4k5rA:
53.0
6brdB-4k5rA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5r OXYGENASE

(Streptomyces
argillaceus)
PF01494
(FAD_binding_3)
5 HIS A  57
ARG A 225
VAL A 214
GLY A 302
MET A 357
None
None
None
FAD  A 601 (-3.4A)
None
0.97A 6brdB-4k5rA:
53.0
6brdB-4k5rA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5r OXYGENASE

(Streptomyces
argillaceus)
PF01494
(FAD_binding_3)
5 HIS A  57
VAL A 214
GLY A 301
GLY A 302
MET A 357
None
None
None
FAD  A 601 (-3.4A)
None
0.64A 6brdB-4k5rA:
53.0
6brdB-4k5rA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5r OXYGENASE

(Streptomyces
argillaceus)
PF01494
(FAD_binding_3)
6 HIS A  57
VAL A 227
PHE A 272
GLY A 301
GLY A 302
MET A 357
None
None
FAD  A 601 ( 4.2A)
None
FAD  A 601 (-3.4A)
None
0.80A 6brdB-4k5rA:
53.0
6brdB-4k5rA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1k D-ALANINE--D-ALANINE
LIGASE


(Xanthomonas
oryzae)
PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C)
5 HIS A  17
GLY A  75
VAL A  76
GLY A  12
GLY A  11
None
1.08A 6brdB-4l1kA:
undetectable
6brdB-4l1kA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mst CLASS I CHITINASE

(Hevea
brasiliensis)
PF00182
(Glyco_hydro_19)
5 GLY A 240
VAL A 243
PHE A 292
THR A 229
GLY A 230
None
0.92A 6brdB-4mstA:
undetectable
6brdB-4mstA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nen INTEGRIN ALPHA-X
INTEGRIN BETA-2


(Homo sapiens)
PF00092
(VWA)
PF00362
(Integrin_beta)
PF01839
(FG-GAP)
PF07965
(Integrin_B_tail)
PF08441
(Integrin_alpha2)
PF17205
(PSI_integrin)
5 GLY B 283
VAL B 282
PHE B 245
THR A 411
GLY A 412
None
1.01A 6brdB-4nenB:
undetectable
6brdB-4nenB:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o89 RNA 3'-TERMINAL
PHOSPHATE CYCLASE


(Pyrococcus
horikoshii)
PF01137
(RTC)
PF05189
(RTC_insert)
5 GLY A 166
ARG A 116
THR A 121
GLY A 120
GLY A 119
None
1.11A 6brdB-4o89A:
undetectable
6brdB-4o89A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oe7 PROBABLE
2-KETO-3-DEOXY-GALAC
TONATE ALDOLASE YAGE


(Escherichia
coli)
PF00701
(DHDPS)
5 GLY A 240
VAL A 242
PHE A 208
GLY A 214
GLY A 215
None
1.15A 6brdB-4oe7A:
undetectable
6brdB-4oe7A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ppz SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE


(Neisseria
meningitidis)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
5 GLY A  67
VAL A 162
THR A 326
GLY A 325
GLY A 324
None
None
None
PO4  A 603 ( 3.7A)
None
1.20A 6brdB-4ppzA:
2.7
6brdB-4ppzA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ppz SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE


(Neisseria
meningitidis)
PF01546
(Peptidase_M20)
PF07687
(M20_dimer)
5 GLY A 163
VAL A 162
THR A 326
GLY A 325
GLY A 324
None
None
None
PO4  A 603 ( 3.7A)
None
1.06A 6brdB-4ppzA:
2.7
6brdB-4ppzA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtf L,D-TRANSPEPTIDASE
LDTB


(Mycobacterium
tuberculosis)
PF03734
(YkuD)
5 GLY A 332
VAL A 333
THR A 384
GLY A 383
GLY A 382
3V5  A 502 (-3.3A)
3V5  A 502 ( 4.9A)
None
None
None
1.22A 6brdB-4qtfA:
undetectable
6brdB-4qtfA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txg CHITINASE

(Chromobacterium
violaceum)
PF00704
(Glyco_hydro_18)
PF06483
(ChiC)
5 PHE A 330
GLY A 289
THR A 258
GLY A 259
GLY A 260
None
0.93A 6brdB-4txgA:
undetectable
6brdB-4txgA:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uar PROTEIN CBBY

(Rhodobacter
sphaeroides)
PF13419
(HAD_2)
5 HIS A  75
GLY A  11
THR A  49
GLY A  50
GLY A  51
None
None
None
GOL  A 301 (-3.4A)
GOL  A 301 ( 4.7A)
1.10A 6brdB-4uarA:
undetectable
6brdB-4uarA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd1 ACETOACETATE-COA
LIGASE


(Streptomyces
lividans)
PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N)
5 HIS A 265
ARG A 227
THR A 166
GLY A 171
GLY A 170
None
1.18A 6brdB-4wd1A:
undetectable
6brdB-4wd1A:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wia PUTATIVE
FLAGELLA-RELATED
PROTEIN H


(Methanocaldococcus
jannaschii)
PF06745
(ATPase)
5 ARG A  46
PHE A  51
GLY A  21
GLY A  22
MET A 182
None
1.12A 6brdB-4wiaA:
undetectable
6brdB-4wiaA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x33 PROTEIN ATS1

(Saccharomyces
cerevisiae)
PF00415
(RCC1)
5 GLY B  59
VAL B  83
PHE B 118
THR B  98
GLY B 113
None
1.18A 6brdB-4x33B:
undetectable
6brdB-4x33B:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xn3 TAIL SPIKE PROTEIN

(Salmonella
virus HK620)
no annotation 5 GLY A 285
VAL A 286
THR A 297
GLY A 298
GLY A 265
None
1.20A 6brdB-4xn3A:
undetectable
6brdB-4xn3A:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yly PEPTIDYL-TRNA
HYDROLASE


(Staphylococcus
aureus)
PF01195
(Pept_tRNA_hydro)
5 GLY A   6
VAL A  88
PHE A 126
GLY A 110
GLY A 109
None
1.14A 6brdB-4ylyA:
2.8
6brdB-4ylyA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c0p ENDO-ARABINASE

(Bacteroides
thetaiotaomicron)
PF04616
(Glyco_hydro_43)
5 HIS A 302
GLY A 217
VAL A 216
GLY A 284
GLY A 285
None
1.13A 6brdB-5c0pA:
undetectable
6brdB-5c0pA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eeb ALDEHYDE
DEHYDROGENASE


(Pyrobaculum
ferrireducens)
PF00171
(Aldedh)
5 GLY A 187
VAL A 185
THR A  93
GLY A  98
GLY A  97
None
1.13A 6brdB-5eebA:
undetectable
6brdB-5eebA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7u CYCLOALTERNAN-FORMIN
G ENZYME


(Listeria
monocytogenes)
PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF16990
(CBM_35)
5 PHE A 393
GLY A 561
VAL A 482
THR A 423
GLY A 394
None
1.22A 6brdB-5f7uA:
undetectable
6brdB-5f7uA:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it1 PUTATIVE CYTOCHROME
P450


(Streptomyces
peucetius)
PF00067
(p450)
5 GLY A 156
ARG A 161
VAL A 157
GLY A 190
GLY A 191
None
None
None
2OH  A 402 ( 4.6A)
None
1.12A 6brdB-5it1A:
undetectable
6brdB-5it1A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j47 LARGE T ANTIGEN

(Human
polyomavirus 2)
PF06431
(Polyoma_lg_T_C)
5 PHE A 377
ARG A 596
PHE A 315
GLY A 378
GLY A 381
None
1.06A 6brdB-5j47A:
undetectable
6brdB-5j47A:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhk LEUCINE
AMINOPEPTIDASE 2,
CHLOROPLASTIC


(Streptomyces
sp. BC16019)
PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N)
5 GLY A 134
ARG A 102
THR A 482
GLY A 481
GLY A 480
None
1.10A 6brdB-5lhkA:
undetectable
6brdB-5lhkA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE


(Homo sapiens)
PF00264
(Tyrosinase)
5 HIS A 381
PHE A 400
THR A 387
GLY A 388
GLY A 389
ZN  A 511 ( 3.3A)
ZN  A 511 ( 4.7A)
None
None
0TR  A 513 (-3.8A)
0.95A 6brdB-5m8tA:
undetectable
6brdB-5m8tA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE KDPC
SUBUNIT


(Escherichia
coli)
PF02669
(KdpC)
5 GLY C  67
ARG C 101
THR C  72
GLY C  83
GLY C  84
None
1.16A 6brdB-5mrwC:
undetectable
6brdB-5mrwC:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4


(Homo sapiens)
no annotation 5 HIS A 287
GLY A 350
VAL A 345
GLY A 276
GLY A 277
None
None
None
None
EDO  A 603 (-4.7A)
0.89A 6brdB-5nqaA:
undetectable
6brdB-5nqaA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nvm EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
TYPE 2


(Homo sapiens)
PF01652
(IF4E)
5 HIS A 217
VAL A 162
THR A 186
GLY A 132
GLY A 133
None
1.20A 6brdB-5nvmA:
2.1
6brdB-5nvmA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8e ARGININE KINASE

(Polybetes
pythagoricus)
PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN)
5 VAL A 250
PHE A 104
THR A 277
GLY A 276
GLY A 266
None
0.93A 6brdB-5u8eA:
1.0
6brdB-5u8eA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uan RETINOIC ACID
RECEPTOR BETA


(Homo sapiens)
no annotation 5 PHE B 104
GLY B 145
VAL B  95
GLY B 103
GLY B 100
None
1.21A 6brdB-5uanB:
undetectable
6brdB-5uanB:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vfd BETA-LACTAMASE

(Acinetobacter
baumannii)
PF00905
(Transpeptidase)
5 PHE A 182
GLY A 230
VAL A 229
THR A 175
GLY A 155
None
1.18A 6brdB-5vfdA:
undetectable
6brdB-5vfdA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xi0 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]


(Aliivibrio
fischeri)
no annotation 5 GLY A  71
VAL A  46
THR A  60
GLY A  64
GLY A  65
None
0.95A 6brdB-5xi0A:
3.5
6brdB-5xi0A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E


(Pseudomonas sp.
AIU 813)
no annotation 5 GLY A 263
VAL A 261
PHE A 110
GLY A  80
GLY A  81
None
None
None
None
FAD  A 601 (-3.0A)
0.97A 6brdB-5yb7A:
10.4
6brdB-5yb7A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zji PHOTOSYSTEM I
REACTION CENTER
SUBUNIT VI,
CHLOROPLASTIC
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT XI


(Zea mays)
no annotation 5 PHE H  94
GLY L 133
THR L 183
GLY L 184
GLY L 185
None
BCR  L 301 ( 4.7A)
None
None
None
0.93A 6brdB-5zjiH:
undetectable
6brdB-5zjiH:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aun PLA2G6, IPLA2BETA

(Cricetulus
griseus)
no annotation 6 GLY A 485
VAL A 486
PHE A 509
THR A 466
GLY A 467
GLY A 468
None
1.41A 6brdB-6aunA:
undetectable
6brdB-6aunA:
20.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6c7s PUTATIVE RIFAMPIN
MONOOXYGENASE


(Nocardia
farcinica)
no annotation 5 HIS A  46
ARG A 351
THR A 284
GLY A 285
GLY A 286
None
None
RFH  A 502 (-4.0A)
RFH  A 502 (-3.4A)
FAD  A 501 ( 3.3A)
1.16A 6brdB-6c7sA:
63.3
6brdB-6c7sA:
74.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6c7s PUTATIVE RIFAMPIN
MONOOXYGENASE


(Nocardia
farcinica)
no annotation 8 HIS A  46
PHE A  74
ARG A 196
GLY A 203
PHE A 256
THR A 284
GLY A 285
GLY A 286
None
RFH  A 502 (-3.4A)
RFH  A 502 (-3.1A)
RFH  A 502 (-3.6A)
RFH  A 502 (-4.4A)
RFH  A 502 (-4.0A)
RFH  A 502 (-3.4A)
FAD  A 501 ( 3.3A)
0.50A 6brdB-6c7sA:
63.3
6brdB-6c7sA:
74.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6c7s PUTATIVE RIFAMPIN
MONOOXYGENASE


(Nocardia
farcinica)
no annotation 7 HIS A  46
PHE A  74
ARG A 196
GLY A 203
PHE A 256
THR A 284
GLY A 286
None
RFH  A 502 (-3.4A)
RFH  A 502 (-3.1A)
RFH  A 502 (-3.6A)
RFH  A 502 (-4.4A)
RFH  A 502 (-4.0A)
FAD  A 501 ( 3.3A)
1.17A 6brdB-6c7sA:
63.3
6brdB-6c7sA:
74.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER


(Enterococcus
casseliflavus)
no annotation 5 HIS A 109
GLY A 153
PHE A 353
GLY A 116
MET A  79
None
1.20A 6brdB-6d0nA:
undetectable
6brdB-6d0nA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE SUBUNIT
BETA


(Trypanosoma
brucei)
no annotation 5 VAL D  81
PHE D  28
THR D  37
GLY D  86
GLY D  85
None
1.18A 6brdB-6f5dD:
undetectable
6brdB-6f5dD:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE]
FLAVOPROTEIN 1,
MITOCHONDRIAL


(Mus musculus)
no annotation 5 PHE F 242
GLY F 121
VAL F 124
GLY F 239
GLY F 238
None
1.18A 6brdB-6g2jF:
undetectable
6brdB-6g2jF:
26.14