SIMILAR PATTERNS OF AMINO ACIDS FOR 6BRD_B_RFPB502

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a2o CHEB METHYLESTERASE

(Salmonella
enterica) 		PF00072
(Response_reg)
PF01339
(CheB_methylest) 		5 GLY A 230
PHE A 104
THR A 168
GLY A 167
GLY A 166
 None
 1.12A 6brdB-1a2oA:
undetectable		 6brdB-1a2oA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bdg HEXOKINASE

(Schistosoma
mansoni) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 GLY A 179
VAL A 180
PHE A 154
THR A 172
GLY A 174
 None
None
None
GLC  A 501 (-2.7A)
None
 1.21A 6brdB-1bdgA:
0.0		 6brdB-1bdgA:
10.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dab P.69 PERTACTIN

(Bordetella
pertussis) 		PF03212
(Pertactin) 		5 HIS A 150
GLY A 243
VAL A 240
GLY A 127
GLY A 147
 None
 1.22A 6brdB-1dabA:
undetectable		 6brdB-1dabA:
10.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e9y UREASE SUBUNIT BETA

(Helicobacter
pylori) 		PF00449
(Urease_alpha)
PF01979
(Amidohydro_1) 		5 PHE B 195
VAL B 369
THR B 171
GLY B 159
GLY B 160
 None
None
KCX  B 219 ( 3.0A)
None
None
 1.01A 6brdB-1e9yB:
undetectable		 6brdB-1e9yB:
10.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1eww ANTIFREEZE PROTEIN

(Choristoneura
fumiferana) 		PF05264
(CfAFP) 		5 GLY A  44
VAL A  45
THR A  53
GLY A  54
GLY A  71
 None
 1.04A 6brdB-1ewwA:
undetectable		 6brdB-1ewwA:
14.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3n 3-OXOACYL-(ACYL-CARR
IER PROTEIN)
SYNTHASE II

(Thermus
thermophilus) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 GLY A   8
VAL A   6
PHE A 405
GLY A 164
GLY A 344
 None
 1.21A 6brdB-1j3nA:
0.0		 6brdB-1j3nA:
11.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jkm BREFELDIN A ESTERASE

(Bacillus
subtilis) 		PF07859
(Abhydrolase_3) 		5 PHE A  40
GLY A 339
VAL A 337
PHE A  29
GLY A  41
 None
 1.06A 6brdB-1jkmA:
0.8		 6brdB-1jkmA:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA

(Paracoccus
denitrificans) 		PF00115
(COX1) 		5 HIS A 411
GLY A 286
THR A 384
GLY A 387
GLY A 386
 HEA  A 602 (-3.4A)
None
HEA  A 602 ( 4.7A)
HEA  A 602 (-3.3A)
None
 1.22A 6brdB-1qleA:
0.0		 6brdB-1qleA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qle CYTOCHROME C OXIDASE
POLYPEPTIDE I-BETA

(Paracoccus
denitrificans) 		PF00115
(COX1) 		5 HIS A 411
GLY A 423
THR A 384
GLY A 387
GLY A 386
 HEA  A 602 (-3.4A)
None
HEA  A 602 ( 4.7A)
HEA  A 602 (-3.3A)
None
 1.16A 6brdB-1qleA:
0.0		 6brdB-1qleA:
9.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w18 LEVANSUCRASE

(Gluconacetobacter
diazotrophicus) 		PF02435
(Glyco_hydro_68) 		5 PHE A 180
VAL A 240
PHE A 282
GLY A 200
GLY A 201
 None
 1.11A 6brdB-1w18A:
undetectable		 6brdB-1w18A:
12.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ybe NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE

(Agrobacterium
tumefaciens) 		PF04095
(NAPRTase) 		5 PHE A 429
VAL A 305
PHE A 311
THR A 294
GLY A 293
 None
 1.06A 6brdB-1ybeA:
undetectable		 6brdB-1ybeA:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yr2 PROLYL
OLIGOPEPTIDASE

(Novosphingobium
capsulatum) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		5 PHE A 498
GLY A 582
VAL A 584
GLY A 497
GLY A 527
 None
 1.19A 6brdB-1yr2A:
undetectable		 6brdB-1yr2A:
8.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yzy HYPOTHETICAL PROTEIN
HI1011

(Haemophilus
influenzae) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		5 GLY A  90
ARG A  50
THR A 217
GLY A 218
GLY A 219
 None
 1.14A 6brdB-1yzyA:
undetectable		 6brdB-1yzyA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cmt PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
E

(Schistosoma
mansoni) 		PF00160
(Pro_isomerase) 		5 GLY A 103
VAL A 139
GLY A  71
GLY A  72
MET A 149
 None
 0.93A 6brdB-2cmtA:
undetectable		 6brdB-2cmtA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT E

(Methanothermobacter
thermautotrophicus) 		PF02637
(GatB_Yqey)
PF02934
(GatB_N)
PF02938
(GAD) 		5 GLY C 170
VAL C 171
THR C 127
GLY C 128
GLY C 129
 None
 1.05A 6brdB-2d6fC:
0.9		 6brdB-2d6fC:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eij CYTOCHROME C OXIDASE
SUBUNIT 1

(Bos taurus) 		PF00115
(COX1) 		5 HIS A 376
GLY A 250
THR A 349
GLY A 352
GLY A 351
 HEA  A 516 (-3.3A)
None
HEA  A 516 ( 4.2A)
HEA  A 516 (-3.5A)
None
 1.10A 6brdB-2eijA:
undetectable		 6brdB-2eijA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fel 3-CARBOXY-CIS,CIS-MU
CONATE LACTONIZING
ENZYME

(Agrobacterium
tumefaciens) 		PF00206
(Lyase_1) 		5 GLY A 314
ARG A 231
THR A 107
GLY A 196
GLY A 195
 None
 1.21A 6brdB-2felA:
undetectable		 6brdB-2felA:
12.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gdu SUCROSE
PHOSPHORYLASE

(Bifidobacterium
adolescentis) 		PF00128
(Alpha-amylase)
PF09244
(DUF1964) 		5 HIS A 234
PHE A 253
ARG A 365
GLY A 381
GLY A 293
 SUC  A2064 (-3.9A)
None
None
None
None
 1.09A 6brdB-2gduA:
undetectable		 6brdB-2gduA:
10.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hyk BETA-1,3-GLUCANASE

(Nocardiopsis
sp. F96) 		PF00722
(Glyco_hydro_16) 		5 HIS A 142
ARG A 132
GLY A 222
GLY A 149
GLY A 148
 GOL  A 249 ( 4.1A)
None
None
None
GOL  A 250 ( 3.4A)
 0.99A 6brdB-2hykA:
undetectable		 6brdB-2hykA:
18.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nzt HEXOKINASE-2

(Homo sapiens) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		5 GLY A 179
VAL A 180
PHE A 154
THR A 172
GLY A 174
 None
None
None
GLC  A1001 (-2.7A)
None
 1.12A 6brdB-2nztA:
undetectable		 6brdB-2nztA:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ood BLR3880 PROTEIN

(Bradyrhizobium
diazoefficiens) 		PF01979
(Amidohydro_1) 		5 GLY A 330
VAL A 327
PHE A 123
THR A 132
GLY A 131
 None
 1.17A 6brdB-2oodA:
undetectable		 6brdB-2oodA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qm1 GLUCOKINASE

(Enterococcus
faecalis) 		PF00480
(ROK) 		5 GLY A 192
VAL A 193
PHE A 226
GLY A 267
GLY A 266
 None
 1.20A 6brdB-2qm1A:
undetectable		 6brdB-2qm1A:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qne PUTATIVE
METHYLTRANSFERASE

(Desulfitobacterium
hafniense) 		PF06253
(MTTB) 		5 GLY A 132
PHE A 361
THR A 346
GLY A 312
GLY A 313
 EDO  A 477 (-3.2A)
None
None
None
None
 1.11A 6brdB-2qneA:
undetectable		 6brdB-2qneA:
8.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v4j SULFITE REDUCTASE,
DISSIMILATORY-TYPE
SUBUNIT BETA

(Desulfovibrio
vulgaris) 		PF01077
(NIR_SIR)
PF03460
(NIR_SIR_ferr) 		5 GLY B 138
ARG B  98
VAL B 139
GLY B 286
GLY B 287
 None
SH0  A 503 (-3.9A)
None
None
None
 0.98A 6brdB-2v4jB:
undetectable		 6brdB-2v4jB:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2v9y PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
CYCLO-LIGASE

(Homo sapiens) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		5 GLY A 618
THR A 682
GLY A 683
GLY A 684
MET A 519
 None
 1.04A 6brdB-2v9yA:
undetectable		 6brdB-2v9yA:
14.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2woc ADP-RIBOSYL-[DINITRO
GEN REDUCTASE]
GLYCOHYDROLASE

(Rhodospirillum
rubrum) 		PF03747
(ADP_ribosyl_GH) 		5 GLY A 248
VAL A 238
THR A  46
GLY A  47
GLY A  48
 None
 1.06A 6brdB-2wocA:
undetectable		 6brdB-2wocA:
15.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xn1 ALPHA-GALACTOSIDASE

(Lactobacillus
acidophilus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		5 HIS A 203
ARG A 377
GLY A 372
GLY A 532
GLY A 533
 GOL  A1734 ( 4.4A)
None
None
GOL  A1734 ( 3.3A)
TRS  A1733 (-4.4A)
 1.17A 6brdB-2xn1A:
undetectable		 6brdB-2xn1A:
7.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xt0 HALOALKANE
DEHALOGENASE

(Plesiocystis
pacifica) 		PF00561
(Abhydrolase_1) 		5 MET A  65
VAL A 280
GLY A 126
GLY A 125
MET A 257
 None
 0.98A 6brdB-2xt0A:
undetectable		 6brdB-2xt0A:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y9x LECTIN-LIKE FOLD
PROTEIN
POLYPHENOL OXIDASE

(Agaricus
bisporus) 		PF00264
(Tyrosinase)
no annotation 		5 HIS A 251
GLY E  13
VAL E 150
THR A  87
GLY A 245
 None
 1.02A 6brdB-2y9xA:
undetectable		 6brdB-2y9xA:
10.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yfn ALPHA-GALACTOSIDASE-
SUCROSE KINASE AGASK

([Ruminococcus]
gnavus) 		PF02065
(Melibiase)
PF16874
(Glyco_hydro_36C)
PF16875
(Glyco_hydro_36N) 		5 HIS A 199
ARG A 373
GLY A 368
GLY A 520
GLY A 521
 None
 1.18A 6brdB-2yfnA:
undetectable		 6brdB-2yfnA:
8.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cmb ACETOACETATE
DECARBOXYLASE

(Methanoculleus
marisnigri) 		PF06314
(ADC) 		5 GLY A 114
THR A   9
GLY A  19
GLY A  18
MET A 258
 P33  A 269 ( 4.5A)
None
None
None
None
 1.02A 6brdB-3cmbA:
undetectable		 6brdB-3cmbA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cyv UROPORPHYRINOGEN
DECARBOXYLASE

(Shigella
flexneri) 		PF01208
(URO-D) 		5 ARG A  27
GLY A 328
THR A 249
GLY A 211
GLY A 212
 None
 1.21A 6brdB-3cyvA:
undetectable		 6brdB-3cyvA:
14.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dl0 ADENYLATE KINASE

(Bacillus
subtilis) 		PF00406
(ADK)
PF05191
(ADK_lid) 		5 HIS A  28
VAL A 115
THR A  15
GLY A  14
GLY A  17
 None
None
AP5  A 218 (-3.6A)
AP5  A 218 (-3.7A)
None
 1.19A 6brdB-3dl0A:
undetectable		 6brdB-3dl0A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g8m SERINE
HYDROXYMETHYLTRANSFE
RASE

(Escherichia
coli) 		PF00464
(SHMT) 		5 HIS A 129
PHE A 198
VAL A 208
GLY A 172
GLY A 173
 None
 1.13A 6brdB-3g8mA:
undetectable		 6brdB-3g8mA:
13.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ij3 CYTOSOL
AMINOPEPTIDASE

(Coxiella
burnetii) 		PF00883
(Peptidase_M17) 		5 HIS A 255
ARG A 341
GLY A 338
GLY A 252
GLY A 251
 None
SO4  A 461 ( 3.6A)
None
None
None
 1.10A 6brdB-3ij3A:
undetectable		 6brdB-3ij3A:
10.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n2x UNCHARACTERIZED
PROTEIN YAGE

(Escherichia
coli) 		PF00701
(DHDPS) 		5 GLY A 240
VAL A 242
PHE A 208
GLY A 214
GLY A 215
 None
 1.15A 6brdB-3n2xA:
undetectable		 6brdB-3n2xA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3omn CYTOCHROME C
OXIDASE, AA3 TYPE,
SUBUNIT I

(Rhodobacter
sphaeroides) 		PF00115
(COX1) 		5 HIS A 419
GLY A 431
THR A 392
GLY A 395
GLY A 394
 HEA  A   2 (-3.2A)
None
HEA  A   2 ( 3.9A)
HEA  A   2 (-3.4A)
None
 1.08A 6brdB-3omnA:
undetectable		 6brdB-3omnA:
9.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p5m ENOYL-COA
HYDRATASE/ISOMERASE

(Mycobacterium
avium) 		PF00378
(ECH_1) 		5 PHE A 233
GLY A  62
VAL A 100
THR A 126
GLY A 129
 None
 1.18A 6brdB-3p5mA:
undetectable		 6brdB-3p5mA:
14.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sft CHEMOTAXIS RESPONSE
REGULATOR
PROTEIN-GLUTAMATE
METHYLESTERASE

(Thermotoga
maritima) 		PF01339
(CheB_methylest) 		5 GLY A 290
VAL A 321
THR A 303
GLY A 302
GLY A 301
 None
 0.96A 6brdB-3sftA:
undetectable		 6brdB-3sftA:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sze SERINE PROTEASE ESPP

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		5 GLY A 668
VAL A 648
THR A 705
GLY A 706
GLY A 707
 None
 1.20A 6brdB-3szeA:
undetectable		 6brdB-3szeA:
6.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3uma HYPOTHETICAL
PEROXIREDOXIN
PROTEIN

(Sinorhizobium
meliloti) 		PF08534
(Redoxin) 		5 GLY A  43
VAL A  41
PHE A  39
GLY A  91
GLY A  92
 None
 1.08A 6brdB-3umaA:
undetectable		 6brdB-3umaA:
19.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vta CUCUMISIN

(Cucumis melo) 		PF00082
(Peptidase_S8) 		5 ARG A 332
GLY A 226
THR A 211
GLY A 232
GLY A 214
 None
 1.21A 6brdB-3vtaA:
undetectable		 6brdB-3vtaA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ain GLYCINE BETAINE
TRANSPORTER BETP

(Corynebacterium
glutamicum) 		PF02028
(BCCT) 		6 GLY A 201
VAL A 200
PHE A 529
THR A 246
GLY A 249
MET A 479
 None
 1.35A 6brdB-4ainA:
undetectable		 6brdB-4ainA:
10.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		5 GLY B2947
PHE B3144
GLY B2938
GLY B2937
MET B3103
 None
 1.15A 6brdB-4bedB:
undetectable		 6brdB-4bedB:
4.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bhl ARGININE KINASE

(Litopenaeus
vannamei) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 VAL A 250
PHE A 104
THR A 277
GLY A 276
GLY A 266
 None
 0.99A 6brdB-4bhlA:
1.0		 6brdB-4bhlA:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ccy CARBOXYLESTERASE
YBFK

(Bacillus
subtilis) 		PF12697
(Abhydrolase_6) 		5 HIS B  62
GLY B 220
PHE B 162
GLY B  64
GLY B  63
 None
 1.17A 6brdB-4ccyB:
undetectable		 6brdB-4ccyB:
14.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d4p PROTEIN ATS1,
DIPHTHAMIDE
BIOSYNTHESIS PROTEIN
3

(Saccharomyces
cerevisiae) 		PF00415
(RCC1)
PF05207
(zf-CSL) 		5 GLY A  59
VAL A  83
PHE A 118
THR A  98
GLY A 113
 None
 1.13A 6brdB-4d4pA:
undetectable		 6brdB-4d4pA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e0t CYCLIC DIPEPTIDE
N-PRENYLTRANSFERASE

(Aspergillus
fumigatus) 		PF11991
(Trp_DMAT) 		5 GLY A  95
VAL A 135
THR A 108
GLY A 111
GLY A 110
 None
None
EDO  A 603 (-4.6A)
None
None
 1.08A 6brdB-4e0tA:
undetectable		 6brdB-4e0tA:
12.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g4i 4-O-METHYL-GLUCURONO
YL METHYLESTERASE

(Thermothelomyces
thermophila) 		no annotation 5 GLY A 337
MET A 320
THR A 210
GLY A 211
GLY A 216
 None
 1.16A 6brdB-4g4iA:
undetectable		 6brdB-4g4iA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjl NAPHTHALENE
1,2-DIOXYGENASE
SUBUNIT ALPHA

(Pseudomonas sp.
C18) 		PF00355
(Rieske)
PF00848
(Ring_hydroxyl_A) 		5 HIS A 261
GLY A 178
PHE A 147
THR A 308
GLY A 311
 None
 1.11A 6brdB-4hjlA:
undetectable		 6brdB-4hjlA:
11.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i3f SERINE HYDROLASE
CCSP0084

(Cycloclasticus
sp. P1) 		PF12697
(Abhydrolase_6) 		5 GLY A 131
VAL A 130
THR A 201
GLY A 200
GLY A 199
 None
 1.22A 6brdB-4i3fA:
undetectable		 6brdB-4i3fA:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ip4 MANDELATE
RACEMASE/MUCONATE
LACTONIZING
ENZYME-LIKE PROTEIN

(Ruegeria sp.
TM1040) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 GLY A  69
VAL A  72
PHE A  87
GLY A 328
GLY A 327
 None
 1.12A 6brdB-4ip4A:
undetectable		 6brdB-4ip4A:
12.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrm 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Vibrio cholerae) 		no annotation 5 GLY D  10
VAL D   8
PHE D 411
GLY D 167
GLY D 348
 None
 1.21A 6brdB-4jrmD:
undetectable		 6brdB-4jrmD:
11.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3j HEPATOCYTE GROWTH
FACTOR
HEPATOCYTE GROWTH
FACTOR BETA CHAIN

(Homo sapiens) 		PF00089
(Trypsin)
PF01403
(Sema)
PF01437
(PSI) 		5 HIS A 517
GLY B 225
MET B 227
ARG B 218
GLY A 618
 None
 1.08A 6brdB-4k3jA:
undetectable		 6brdB-4k3jA:
17.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5r OXYGENASE

(Streptomyces
argillaceus) 		PF01494
(FAD_binding_3) 		5 HIS A  57
ARG A 225
PHE A 272
GLY A 302
MET A 357
 None
None
FAD  A 601 ( 4.2A)
FAD  A 601 (-3.4A)
None
 0.99A 6brdB-4k5rA:
53.0		 6brdB-4k5rA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5r OXYGENASE

(Streptomyces
argillaceus) 		PF01494
(FAD_binding_3) 		5 HIS A  57
ARG A 225
VAL A 214
GLY A 302
MET A 357
 None
None
None
FAD  A 601 (-3.4A)
None
 0.97A 6brdB-4k5rA:
53.0		 6brdB-4k5rA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5r OXYGENASE

(Streptomyces
argillaceus) 		PF01494
(FAD_binding_3) 		5 HIS A  57
VAL A 214
GLY A 301
GLY A 302
MET A 357
 None
None
None
FAD  A 601 (-3.4A)
None
 0.64A 6brdB-4k5rA:
53.0		 6brdB-4k5rA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k5r OXYGENASE

(Streptomyces
argillaceus) 		PF01494
(FAD_binding_3) 		6 HIS A  57
VAL A 227
PHE A 272
GLY A 301
GLY A 302
MET A 357
 None
None
FAD  A 601 ( 4.2A)
None
FAD  A 601 (-3.4A)
None
 0.80A 6brdB-4k5rA:
53.0		 6brdB-4k5rA:
12.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l1k D-ALANINE--D-ALANINE
LIGASE

(Xanthomonas
oryzae) 		PF01820
(Dala_Dala_lig_N)
PF07478
(Dala_Dala_lig_C) 		5 HIS A  17
GLY A  75
VAL A  76
GLY A  12
GLY A  11
 None
 1.08A 6brdB-4l1kA:
undetectable		 6brdB-4l1kA:
11.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mst CLASS I CHITINASE

(Hevea
brasiliensis) 		PF00182
(Glyco_hydro_19) 		5 GLY A 240
VAL A 243
PHE A 292
THR A 229
GLY A 230
 None
 0.92A 6brdB-4mstA:
undetectable		 6brdB-4mstA:
15.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nen INTEGRIN ALPHA-X
INTEGRIN BETA-2

(Homo sapiens) 		PF00092
(VWA)
PF00362
(Integrin_beta)
PF01839
(FG-GAP)
PF07965
(Integrin_B_tail)
PF08441
(Integrin_alpha2)
PF17205
(PSI_integrin) 		5 GLY B 283
VAL B 282
PHE B 245
THR A 411
GLY A 412
 None
 1.01A 6brdB-4nenB:
undetectable		 6brdB-4nenB:
8.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o89 RNA 3'-TERMINAL
PHOSPHATE CYCLASE

(Pyrococcus
horikoshii) 		PF01137
(RTC)
PF05189
(RTC_insert) 		5 GLY A 166
ARG A 116
THR A 121
GLY A 120
GLY A 119
 None
 1.11A 6brdB-4o89A:
undetectable		 6brdB-4o89A:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oe7 PROBABLE
2-KETO-3-DEOXY-GALAC
TONATE ALDOLASE YAGE

(Escherichia
coli) 		PF00701
(DHDPS) 		5 GLY A 240
VAL A 242
PHE A 208
GLY A 214
GLY A 215
 None
 1.15A 6brdB-4oe7A:
undetectable		 6brdB-4oe7A:
15.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ppz SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Neisseria
meningitidis) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 GLY A  67
VAL A 162
THR A 326
GLY A 325
GLY A 324
 None
None
None
PO4  A 603 ( 3.7A)
None
 1.20A 6brdB-4ppzA:
2.7		 6brdB-4ppzA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ppz SUCCINYL-DIAMINOPIME
LATE DESUCCINYLASE

(Neisseria
meningitidis) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		5 GLY A 163
VAL A 162
THR A 326
GLY A 325
GLY A 324
 None
None
None
PO4  A 603 ( 3.7A)
None
 1.06A 6brdB-4ppzA:
2.7		 6brdB-4ppzA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qtf L,D-TRANSPEPTIDASE
LDTB

(Mycobacterium
tuberculosis) 		PF03734
(YkuD) 		5 GLY A 332
VAL A 333
THR A 384
GLY A 383
GLY A 382
 3V5  A 502 (-3.3A)
3V5  A 502 ( 4.9A)
None
None
None
 1.22A 6brdB-4qtfA:
undetectable		 6brdB-4qtfA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4txg CHITINASE

(Chromobacterium
violaceum) 		PF00704
(Glyco_hydro_18)
PF06483
(ChiC) 		5 PHE A 330
GLY A 289
THR A 258
GLY A 259
GLY A 260
 None
 0.93A 6brdB-4txgA:
undetectable		 6brdB-4txgA:
7.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uar PROTEIN CBBY

(Rhodobacter
sphaeroides) 		PF13419
(HAD_2) 		5 HIS A  75
GLY A  11
THR A  49
GLY A  50
GLY A  51
 None
None
None
GOL  A 301 (-3.4A)
GOL  A 301 ( 4.7A)
 1.10A 6brdB-4uarA:
undetectable		 6brdB-4uarA:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd1 ACETOACETATE-COA
LIGASE

(Streptomyces
lividans) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C)
PF16177
(ACAS_N) 		5 HIS A 265
ARG A 227
THR A 166
GLY A 171
GLY A 170
 None
 1.18A 6brdB-4wd1A:
undetectable		 6brdB-4wd1A:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wia PUTATIVE
FLAGELLA-RELATED
PROTEIN H

(Methanocaldococcus
jannaschii) 		PF06745
(ATPase) 		5 ARG A  46
PHE A  51
GLY A  21
GLY A  22
MET A 182
 None
 1.12A 6brdB-4wiaA:
undetectable		 6brdB-4wiaA:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x33 PROTEIN ATS1

(Saccharomyces
cerevisiae) 		PF00415
(RCC1) 		5 GLY B  59
VAL B  83
PHE B 118
THR B  98
GLY B 113
 None
 1.18A 6brdB-4x33B:
undetectable		 6brdB-4x33B:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xn3 TAIL SPIKE PROTEIN

(Salmonella
virus HK620) 		no annotation 5 GLY A 285
VAL A 286
THR A 297
GLY A 298
GLY A 265
 None
 1.20A 6brdB-4xn3A:
undetectable		 6brdB-4xn3A:
8.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yly PEPTIDYL-TRNA
HYDROLASE

(Staphylococcus
aureus) 		PF01195
(Pept_tRNA_hydro) 		5 GLY A   6
VAL A  88
PHE A 126
GLY A 110
GLY A 109
 None
 1.14A 6brdB-4ylyA:
2.8		 6brdB-4ylyA:
16.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c0p ENDO-ARABINASE

(Bacteroides
thetaiotaomicron) 		PF04616
(Glyco_hydro_43) 		5 HIS A 302
GLY A 217
VAL A 216
GLY A 284
GLY A 285
 None
 1.13A 6brdB-5c0pA:
undetectable		 6brdB-5c0pA:
13.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eeb ALDEHYDE
DEHYDROGENASE

(Pyrobaculum
ferrireducens) 		PF00171
(Aldedh) 		5 GLY A 187
VAL A 185
THR A  93
GLY A  98
GLY A  97
 None
 1.13A 6brdB-5eebA:
undetectable		 6brdB-5eebA:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f7u CYCLOALTERNAN-FORMIN
G ENZYME

(Listeria
monocytogenes) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2)
PF16338
(DUF4968)
PF16990
(CBM_35) 		5 PHE A 393
GLY A 561
VAL A 482
THR A 423
GLY A 394
 None
 1.22A 6brdB-5f7uA:
undetectable		 6brdB-5f7uA:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5it1 PUTATIVE CYTOCHROME
P450

(Streptomyces
peucetius) 		PF00067
(p450) 		5 GLY A 156
ARG A 161
VAL A 157
GLY A 190
GLY A 191
 None
None
None
2OH  A 402 ( 4.6A)
None
 1.12A 6brdB-5it1A:
undetectable		 6brdB-5it1A:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5j47 LARGE T ANTIGEN

(Human
polyomavirus 2) 		PF06431
(Polyoma_lg_T_C) 		5 PHE A 377
ARG A 596
PHE A 315
GLY A 378
GLY A 381
 None
 1.06A 6brdB-5j47A:
undetectable		 6brdB-5j47A:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhk LEUCINE
AMINOPEPTIDASE 2,
CHLOROPLASTIC

(Streptomyces
sp. BC16019) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 GLY A 134
ARG A 102
THR A 482
GLY A 481
GLY A 480
 None
 1.10A 6brdB-5lhkA:
undetectable		 6brdB-5lhkA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE

(Homo sapiens) 		PF00264
(Tyrosinase) 		5 HIS A 381
PHE A 400
THR A 387
GLY A 388
GLY A 389
 ZN  A 511 ( 3.3A)
ZN  A 511 ( 4.7A)
None
None
0TR  A 513 (-3.8A)
 0.95A 6brdB-5m8tA:
undetectable		 6brdB-5m8tA:
11.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mrw POTASSIUM-TRANSPORTI
NG ATPASE KDPC
SUBUNIT

(Escherichia
coli) 		PF02669
(KdpC) 		5 GLY C  67
ARG C 101
THR C  72
GLY C  83
GLY C  84
 None
 1.16A 6brdB-5mrwC:
undetectable		 6brdB-5mrwC:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nqa POLYPEPTIDE
N-ACETYLGALACTOSAMIN
YLTRANSFERASE 4

(Homo sapiens) 		no annotation 5 HIS A 287
GLY A 350
VAL A 345
GLY A 276
GLY A 277
 None
None
None
None
EDO  A 603 (-4.7A)
 0.89A 6brdB-5nqaA:
undetectable		 6brdB-5nqaA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nvm EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E
TYPE 2

(Homo sapiens) 		PF01652
(IF4E) 		5 HIS A 217
VAL A 162
THR A 186
GLY A 132
GLY A 133
 None
 1.20A 6brdB-5nvmA:
2.1		 6brdB-5nvmA:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u8e ARGININE KINASE

(Polybetes
pythagoricus) 		PF00217
(ATP-gua_Ptrans)
PF02807
(ATP-gua_PtransN) 		5 VAL A 250
PHE A 104
THR A 277
GLY A 276
GLY A 266
 None
 0.93A 6brdB-5u8eA:
1.0		 6brdB-5u8eA:
11.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uan RETINOIC ACID
RECEPTOR BETA

(Homo sapiens) 		no annotation 5 PHE B 104
GLY B 145
VAL B  95
GLY B 103
GLY B 100
 None
 1.21A 6brdB-5uanB:
undetectable		 6brdB-5uanB:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vfd BETA-LACTAMASE

(Acinetobacter
baumannii) 		PF00905
(Transpeptidase) 		5 PHE A 182
GLY A 230
VAL A 229
THR A 175
GLY A 155
 None
 1.18A 6brdB-5vfdA:
undetectable		 6brdB-5vfdA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xi0 ENOYL-[ACYL-CARRIER-
PROTEIN] REDUCTASE
[NADH]

(Aliivibrio
fischeri) 		no annotation 5 GLY A  71
VAL A  46
THR A  60
GLY A  64
GLY A  65
 None
 0.95A 6brdB-5xi0A:
3.5		 6brdB-5xi0A:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yb7 L-AMINO ACID
OXIDASE/MONOOXYGENAS
E

(Pseudomonas sp.
AIU 813) 		no annotation 5 GLY A 263
VAL A 261
PHE A 110
GLY A  80
GLY A  81
 None
None
None
None
FAD  A 601 (-3.0A)
 0.97A 6brdB-5yb7A:
10.4		 6brdB-5yb7A:
23.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zji PHOTOSYSTEM I
REACTION CENTER
SUBUNIT VI,
CHLOROPLASTIC
PHOTOSYSTEM I
REACTION CENTER
SUBUNIT XI

(Zea mays) 		no annotation 5 PHE H  94
GLY L 133
THR L 183
GLY L 184
GLY L 185
 None
BCR  L 301 ( 4.7A)
None
None
None
 0.93A 6brdB-5zjiH:
undetectable		 6brdB-5zjiH:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aun PLA2G6, IPLA2BETA

(Cricetulus
griseus) 		no annotation 6 GLY A 485
VAL A 486
PHE A 509
THR A 466
GLY A 467
GLY A 468
 None
 1.41A 6brdB-6aunA:
undetectable		 6brdB-6aunA:
20.21
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6c7s PUTATIVE RIFAMPIN
MONOOXYGENASE

(Nocardia
farcinica) 		no annotation 5 HIS A  46
ARG A 351
THR A 284
GLY A 285
GLY A 286
 None
None
RFH  A 502 (-4.0A)
RFH  A 502 (-3.4A)
FAD  A 501 ( 3.3A)
 1.16A 6brdB-6c7sA:
63.3		 6brdB-6c7sA:
74.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6c7s PUTATIVE RIFAMPIN
MONOOXYGENASE

(Nocardia
farcinica) 		no annotation 8 HIS A  46
PHE A  74
ARG A 196
GLY A 203
PHE A 256
THR A 284
GLY A 285
GLY A 286
 None
RFH  A 502 (-3.4A)
RFH  A 502 (-3.1A)
RFH  A 502 (-3.6A)
RFH  A 502 (-4.4A)
RFH  A 502 (-4.0A)
RFH  A 502 (-3.4A)
FAD  A 501 ( 3.3A)
 0.50A 6brdB-6c7sA:
63.3		 6brdB-6c7sA:
74.03
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6c7s PUTATIVE RIFAMPIN
MONOOXYGENASE

(Nocardia
farcinica) 		no annotation 7 HIS A  46
PHE A  74
ARG A 196
GLY A 203
PHE A 256
THR A 284
GLY A 286
 None
RFH  A 502 (-3.4A)
RFH  A 502 (-3.1A)
RFH  A 502 (-3.6A)
RFH  A 502 (-4.4A)
RFH  A 502 (-4.0A)
FAD  A 501 ( 3.3A)
 1.17A 6brdB-6c7sA:
63.3		 6brdB-6c7sA:
74.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d0n CLC-TYPE
FLUORIDE/PROTON
ANTIPORTER

(Enterococcus
casseliflavus) 		no annotation 5 HIS A 109
GLY A 153
PHE A 353
GLY A 116
MET A  79
 None
 1.20A 6brdB-6d0nA:
undetectable		 6brdB-6d0nA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f5d ATP SYNTHASE SUBUNIT
BETA

(Trypanosoma
brucei) 		no annotation 5 VAL D  81
PHE D  28
THR D  37
GLY D  86
GLY D  85
 None
 1.18A 6brdB-6f5dD:
undetectable		 6brdB-6f5dD:
20.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6g2j NADH DEHYDROGENASE
[UBIQUINONE]
FLAVOPROTEIN 1,
MITOCHONDRIAL

(Mus musculus) 		no annotation 5 PHE F 242
GLY F 121
VAL F 124
GLY F 239
GLY F 238
 None
 1.18A 6brdB-6g2jF:
undetectable		 6brdB-6g2jF:
26.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a6d THERMOSOME (BETA
SUBUNIT)

(Thermoplasma
acidophilum) 		PF00118
(Cpn60_TCP1) 		4 GLN B 110
MET B  80
ARG B 515
PRO B 119
 None
 1.24A 6brdB-1a6dB:
0.7		 6brdB-1a6dB:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dm3 BIOSYNTHETIC
THIOLASE ACETYLATED
AT CYS89

(Zoogloea
ramigera) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 GLN A  56
LEU A  30
ARG A  12
PRO A 349
 None
 1.33A 6brdB-1dm3A:
0.0		 6brdB-1dm3A:
11.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ewr DNA MISMATCH REPAIR
PROTEIN MUTS

(Thermus
aquaticus) 		PF00488
(MutS_V)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		4 GLN A 289
VAL A 529
LEU A 257
PRO A 295
 None
 1.07A 6brdB-1ewrA:
0.0		 6brdB-1ewrA:
8.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f0k UDP-N-ACETYLGLUCOSAM
INE-N-ACETYLMURAMYL-
(PENTAPEPTIDE)
PYROPHOSPHORYL-UNDEC
APRENOL
N-ACETYLGLUCOSAMINE
TRANSFERASE

(Escherichia
coli) 		PF03033
(Glyco_transf_28)
PF04101
(Glyco_tran_28_C) 		4 VAL A 167
LEU A 328
ARG A 333
PRO A 276
 None
 1.29A 6brdB-1f0kA:
1.1		 6brdB-1f0kA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hvy THYMIDYLATE SYNTHASE

(Homo sapiens) 		PF00303
(Thymidylat_synt) 		4 GLN A  32
LEU A  74
ARG A 271
PRO A 273
 None
 1.21A 6brdB-1hvyA:
0.0		 6brdB-1hvyA:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ion PROBABLE CELL
DIVISION INHIBITOR
MIND

(Pyrococcus
horikoshii) 		PF13614
(AAA_31) 		4 VAL A  49
LEU A 101
ARG A 126
PRO A 120
 None
 1.32A 6brdB-1ionA:
0.0		 6brdB-1ionA:
18.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmz AMINE DEHYDROGENASE

(Pseudomonas
putida) 		PF08992
(QH-AmDH_gamma)
PF09098
(Dehyd-heme_bind)
PF09099
(Qn_am_d_aIII)
PF09100
(Qn_am_d_aIV)
PF14930
(Qn_am_d_aII) 		4 VAL A 386
LEU A  38
ARG A  43
PRO G  76
 None
None
HEC  A1002 ( 3.0A)
None
 1.27A 6brdB-1jmzA:
0.0		 6brdB-1jmzA:
12.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k77 HYPOTHETICAL PROTEIN
YGBM

(Escherichia
coli) 		PF01261
(AP_endonuc_2) 		4 GLN A 158
VAL A 165
LEU A 189
ARG A 194
 None
 1.16A 6brdB-1k77A:
0.0		 6brdB-1k77A:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1l4i SFAE PROTEIN

(Escherichia
coli) 		PF00345
(PapD_N)
PF02753
(PapD_C) 		4 VAL A  18
MET A 166
ARG A  79
PRO A 117
 None
 1.26A 6brdB-1l4iA:
0.0		 6brdB-1l4iA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nne DNA MISMATCH REPAIR
PROTEIN MUTS

(Thermus
aquaticus) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05190
(MutS_IV)
PF05192
(MutS_III) 		4 GLN A 289
VAL A 529
LEU A 257
PRO A 295
 None
 1.25A 6brdB-1nneA:
undetectable		 6brdB-1nneA:
7.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ozh ACETOLACTATE
SYNTHASE, CATABOLIC

(Klebsiella
pneumoniae) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		4 GLN A  28
VAL A 102
LEU A 463
ARG A  55
 None
 1.21A 6brdB-1ozhA:
undetectable		 6brdB-1ozhA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p22 F-BOX/WD-REPEAT
PROTEIN 1A

(Homo sapiens) 		PF00400
(WD40)
PF12937
(F-box-like) 		4 GLN A 437
VAL A 395
LEU A 497
ARG A 464
 None
 1.03A 6brdB-1p22A:
undetectable		 6brdB-1p22A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1pie GALACTOKINASE

(Lactococcus
lactis) 		PF00288
(GHMP_kinases_N)
PF08544
(GHMP_kinases_C)
PF10509
(GalKase_gal_bdg) 		4 GLN A 165
VAL A 158
MET A 207
ARG A  36
 None
None
None
PO4  A 401 ( 3.5A)
 1.25A 6brdB-1pieA:
0.1		 6brdB-1pieA:
12.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qmh RNA 3'-TERMINAL
PHOSPHATE CYCLASE

(Escherichia
coli) 		PF01137
(RTC)
PF05189
(RTC_insert) 		4 VAL A 121
LEU A 197
ARG A 249
PRO A 132
 None
 1.28A 6brdB-1qmhA:
undetectable		 6brdB-1qmhA:
13.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rgy BETA-LACTAMASE

(Citrobacter
freundii) 		PF00144
(Beta-lactamase) 		4 GLN A 267
VAL A 313
LEU A 107
PRO A 304
 None
 1.17A 6brdB-1rgyA:
undetectable		 6brdB-1rgyA:
15.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sma MALTOGENIC AMYLASE

(Thermus sp.
IM6501) 		PF00128
(Alpha-amylase)
PF02903
(Alpha-amylase_N)
PF16657
(Malt_amylase_C) 		4 GLN A 127
VAL A 132
ARG A 367
PRO A 409
 None
 1.30A 6brdB-1smaA:
undetectable		 6brdB-1smaA:
9.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t8q GLYCEROPHOSPHORYL
DIESTER
PHOSPHODIESTERASE,
PERIPLASMIC

(Escherichia
coli) 		PF03009
(GDPD) 		4 GLN A 208
VAL A  76
LEU A 215
PRO A 175
 GOL  A1605 ( 4.5A)
None
None
None
 1.20A 6brdB-1t8qA:
undetectable		 6brdB-1t8qA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v7v CHITOBIOSE
PHOSPHORYLASE

(Vibrio
proteolyticus) 		PF06165
(Glyco_transf_36)
PF17167
(Glyco_hydro_36) 		4 GLN A 353
VAL A 329
LEU A 507
PRO A 433
 None
 1.10A 6brdB-1v7vA:
undetectable		 6brdB-1v7vA:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vpb PUTATIVE MODULATOR
OF DNA GYRASE

(Bacteroides
thetaiotaomicron) 		PF01523
(PmbA_TldD) 		4 VAL A 400
LEU A 349
MET A 342
ARG A 419
 None
 0.91A 6brdB-1vpbA:
undetectable		 6brdB-1vpbA:
11.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygu LEUKOCYTE COMMON
ANTIGEN

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 GLN A1094
VAL A1119
LEU A1039
ARG A1145
 None
 1.27A 6brdB-1yguA:
undetectable		 6brdB-1yguA:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2aaz THYMIDYLATE SYNTHASE

(Cryptococcus
neoformans) 		PF00303
(Thymidylat_synt) 		4 GLN A  22
LEU A  66
ARG A 272
PRO A 274
 None
 1.09A 6brdB-2aazA:
undetectable		 6brdB-2aazA:
14.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ahw PUTATIVE ENZYME YDIF

(Escherichia
coli) 		PF01144
(CoA_trans) 		4 GLN A 225
VAL A  15
LEU A  41
ARG A 241
 None
 1.16A 6brdB-2ahwA:
undetectable		 6brdB-2ahwA:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bll PROTEIN YFBG

(Escherichia
coli) 		PF01370
(Epimerase) 		4 GLN A 533
VAL A 603
ARG A 510
PRO A 395
 None
 1.33A 6brdB-2bllA:
undetectable		 6brdB-2bllA:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d0j GALACTOSYLGALACTOSYL
XYLOSYLPROTEIN
3-BETA-GLUCURONOSYLT
RANSFERASE 2

(Homo sapiens) 		PF03360
(Glyco_transf_43) 		4 GLN A 279
VAL A 249
ARG A 235
PRO A 239
 None
 1.18A 6brdB-2d0jA:
undetectable		 6brdB-2d0jA:
16.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2de0 ALPHA-(1,6)-FUCOSYLT
RANSFERASE

(Homo sapiens) 		PF14604
(SH3_9) 		4 GLN X 480
VAL X 319
MET X 232
ARG X 337
 None
 1.32A 6brdB-2de0X:
undetectable		 6brdB-2de0X:
13.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fk7 METHOXY MYCOLIC ACID
SYNTHASE 4

(Mycobacterium
tuberculosis) 		PF02353
(CMAS) 		4 GLN A  36
VAL A  27
LEU A  54
ARG A 246
 None
 1.28A 6brdB-2fk7A:
undetectable		 6brdB-2fk7A:
13.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h2q BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Trypanosoma
cruzi) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 GLN A 239
LEU A 282
ARG A 479
PRO A 481
 None
 1.15A 6brdB-2h2qA:
undetectable		 6brdB-2h2qA:
10.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ime 2-HYDROXYCHROMENE-2-
CARBOXYLATE
ISOMERASE

(Pseudomonas
putida) 		PF01323
(DSBA) 		4 GLN A  19
VAL A 106
MET A 191
ARG A 183
 None
 1.13A 6brdB-2imeA:
undetectable		 6brdB-2imeA:
16.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2is5 HYPOTHETICAL PROTEIN

(Neisseria
meningitidis) 		PF05838
(Glyco_hydro_108)
PF09374
(PG_binding_3) 		4 GLN A  80
VAL A  12
LEU A 125
PRO A  74
 None
 1.06A 6brdB-2is5A:
undetectable		 6brdB-2is5A:
18.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ogs THERMOSTABLE
CARBOXYLESTERASE
EST50

(Geobacillus
stearothermophilus) 		PF00135
(COesterase) 		4 VAL A 273
LEU A 284
ARG A 282
PRO A 230
 VAL  A 273 ( 0.6A)
LEU  A 284 ( 0.6A)
ARG  A 282 ( 0.6A)
PRO  A 230 ( 1.1A)
 1.16A 6brdB-2ogsA:
undetectable		 6brdB-2ogsA:
11.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pa5 TYROSINE-PROTEIN
PHOSPHATASE
NON-RECEPTOR TYPE 9

(Homo sapiens) 		PF00102
(Y_phosphatase) 		4 VAL A 512
LEU A 434
ARG A 423
PRO A 417
 None
 1.33A 6brdB-2pa5A:
undetectable		 6brdB-2pa5A:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pqd 3-PHOSPHOSHIKIMATE
1-CARBOXYVINYLTRANSF
ERASE

(Agrobacterium
sp.) 		PF00275
(EPSP_synthase) 		4 VAL A 421
LEU A 379
MET A 284
ARG A 382
 None
 1.33A 6brdB-2pqdA:
undetectable		 6brdB-2pqdA:
14.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qf7 PYRUVATE CARBOXYLASE
PROTEIN

(Rhizobium etli) 		PF00289
(Biotin_carb_N)
PF00364
(Biotin_lipoyl)
PF00682
(HMGL-like)
PF02436
(PYC_OADA)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 GLN A 351
VAL A 311
LEU A 438
ARG A 424
 None
 1.11A 6brdB-2qf7A:
undetectable		 6brdB-2qf7A:
6.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qz6 BETA-LACTAMASE

(Pseudomonas
fluorescens) 		PF00144
(Beta-lactamase) 		4 GLN A 267
VAL A 313
LEU A 107
PRO A 304
 None
 1.27A 6brdB-2qz6A:
undetectable		 6brdB-2qz6A:
13.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r94 2-KETO-3-DEOXY-(6-PH
OSPHO-)GLUCONATE
ALDOLASE

(Thermoproteus
tenax) 		PF00701
(DHDPS) 		4 GLN A  90
VAL A 214
LEU A 102
ARG A 109
 None
 1.18A 6brdB-2r94A:
undetectable		 6brdB-2r94A:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rgh ALPHA-GLYCEROPHOSPHA
TE OXIDASE

(Streptococcus
sp.) 		PF01266
(DAO)
PF16901
(DAO_C) 		4 GLN A 465
VAL A  35
ARG A  86
PRO A  97
 None
 1.19A 6brdB-2rghA:
undetectable		 6brdB-2rghA:
11.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xe4 OLIGOPEPTIDASE B

(Leishmania
major) 		PF00326
(Peptidase_S9)
PF02897
(Peptidase_S9_N) 		4 GLN A 713
VAL A 596
MET A 503
PRO A 513
 PGR  A1742 ( 3.2A)
None
PGR  A1764 ( 3.5A)
None
 1.21A 6brdB-2xe4A:
undetectable		 6brdB-2xe4A:
6.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xym RNA-DIRECTED RNA
POLYMERASE

(Hepacivirus C) 		PF00998
(RdRP_3) 		4 GLN A 414
VAL A 454
LEU A 384
PRO A 417
 None
 1.07A 6brdB-2xymA:
1.4		 6brdB-2xymA:
9.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yq1 ORF73

(Murid
gammaherpesvirus
4) 		no annotation 4 GLN A 190
VAL A 221
LEU A 139
ARG A 148
 None
 1.17A 6brdB-2yq1A:
undetectable		 6brdB-2yq1A:
22.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yx0 RADICAL SAM ENZYME

(Pyrococcus
horikoshii) 		PF04055
(Radical_SAM)
PF08608
(Wyosine_form) 		4 GLN A  73
MET A 159
ARG A 169
PRO A 142
 None
 1.13A 6brdB-2yx0A:
undetectable		 6brdB-2yx0A:
12.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zc7 BETA-LACTAMASE ACT-1

(Klebsiella
pneumoniae) 		PF00144
(Beta-lactamase) 		4 GLN A 267
VAL A 313
LEU A 107
PRO A 304
 None
 1.05A 6brdB-2zc7A:
0.0		 6brdB-2zc7A:
10.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zj9 AMPC

(Escherichia
coli) 		PF00144
(Beta-lactamase) 		4 GLN A 267
VAL A 313
LEU A 107
PRO A 304
 IPA  A 362 ( 4.6A)
None
None
None
 1.04A 6brdB-2zj9A:
undetectable		 6brdB-2zj9A:
14.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zws NEUTRAL CERAMIDASE

(Pseudomonas
aeruginosa) 		PF04734
(Ceramidase_alk)
PF17048
(Ceramidse_alk_C) 		4 GLN A 396
VAL A 302
LEU A 405
ARG A 421
 None
 1.33A 6brdB-2zwsA:
undetectable		 6brdB-2zwsA:
8.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a8u OMEGA-AMINO
ACID--PYRUVATE
AMINOTRANSFERASE

(Pseudomonas
putida) 		PF00202
(Aminotran_3) 		4 VAL X 279
LEU X 187
ARG X 378
PRO X 197
 None
 1.33A 6brdB-3a8uX:
undetectable		 6brdB-3a8uX:
10.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b70 ENOYL REDUCTASE

(Aspergillus
terreus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 GLN A 104
VAL A  43
MET A  55
PRO A  30
 None
 1.17A 6brdB-3b70A:
undetectable		 6brdB-3b70A:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bby UNCHARACTERIZED
GST-LIKE PROTEIN
YFCF

(Escherichia
coli) 		PF13417
(GST_N_3)
PF14834
(GST_C_4) 		4 GLN A 196
VAL A  24
LEU A 153
ARG A 101
 None
 1.30A 6brdB-3bbyA:
undetectable		 6brdB-3bbyA:
17.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eb0 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Cryptosporidium
parvum) 		PF00069
(Pkinase) 		4 VAL A 127
LEU A 328
ARG A 152
PRO A 351
 None
 1.32A 6brdB-3eb0A:
undetectable		 6brdB-3eb0A:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3go1 FAB 268-D, LIGHT
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		4 GLN L  89
LEU L  46
ARG L  37
PRO L  44
 None
 1.26A 6brdB-3go1L:
undetectable		 6brdB-3go1L:
14.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibr BACTERIOPHYTOCHROME

(Pseudomonas
aeruginosa) 		PF00360
(PHY)
PF01590
(GAF)
PF08446
(PAS_2) 		4 VAL A 303
MET A 154
ARG A 289
PRO A 207
 None
 1.31A 6brdB-3ibrA:
undetectable		 6brdB-3ibrA:
9.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il0 XAA-PRO
AMINOPEPTIDASE
AMINOPEPTIDASE P

(Streptococcus
thermophilus) 		PF01321
(Creatinase_N) 		4 GLN A 117
VAL A  97
LEU A  12
ARG A  48
 None
None
None
GOL  A 129 (-3.7A)
 1.26A 6brdB-3il0A:
undetectable		 6brdB-3il0A:
19.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k2w BETAINE-ALDEHYDE
DEHYDROGENASE

(Pseudoalteromonas
atlantica) 		PF00171
(Aldedh) 		4 GLN A 327
LEU A 278
ARG A 281
PRO A 374
 None
 1.28A 6brdB-3k2wA:
undetectable		 6brdB-3k2wA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kgb THYMIDYLATE SYNTHASE
1/2

(Encephalitozoon
cuniculi) 		PF00303
(Thymidylat_synt) 		4 GLN A  11
LEU A  54
ARG A 250
PRO A 252
 None
 1.12A 6brdB-3kgbA:
undetectable		 6brdB-3kgbA:
16.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3khw POLYMERASE PB2

(Influenza A
virus) 		PF00604
(Flu_PB2) 		4 VAL A 667
LEU A 571
MET A 603
ARG A 597
 None
 1.31A 6brdB-3khwA:
undetectable		 6brdB-3khwA:
21.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kjr DIHYDROFOLATE
REDUCTASE/THYMIDYLAT
E SYNTHASE

(Babesia bovis) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 GLN A 230
LEU A 272
ARG A 469
PRO A 471
 None
 1.20A 6brdB-3kjrA:
undetectable		 6brdB-3kjrA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n26 AMINO ACID ABC
TRANSPORTER,
PERIPLASMIC AMINO
ACID-BINDING PROTEIN

(Chlamydia
pneumoniae) 		PF00497
(SBP_bac_3) 		4 VAL A 171
LEU A 207
ARG A 204
PRO A 187
 None
 1.15A 6brdB-3n26A:
undetectable		 6brdB-3n26A:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ndn O-SUCCINYLHOMOSERINE
SULFHYDRYLASE

(Mycobacterium
tuberculosis) 		PF01053
(Cys_Met_Meta_PP) 		4 GLN A 172
VAL A 384
LEU A 174
PRO A 305
 None
 1.26A 6brdB-3ndnA:
undetectable		 6brdB-3ndnA:
11.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3okx YAEB-LIKE PROTEIN
RPA0152

(Rhodopseudomonas
palustris) 		PF01980
(UPF0066) 		4 VAL A 140
LEU A  37
ARG A  82
PRO A 105
 None
SAM  A 201 (-4.5A)
None
SAM  A 201 (-3.8A)
 1.08A 6brdB-3okxA:
undetectable		 6brdB-3okxA:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pb0 DIHYDRODIPICOLINATE
SYNTHASE

(Thermotoga
maritima) 		PF00701
(DHDPS) 		4 GLN A  30
VAL A  72
LEU A 259
PRO A  12
 None
 1.26A 6brdB-3pb0A:
undetectable		 6brdB-3pb0A:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pk0 SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE SDR

(Mycolicibacterium
smegmatis) 		PF13561
(adh_short_C2) 		4 GLN A 124
VAL A  65
LEU A 175
ARG A 137
 None
 1.17A 6brdB-3pk0A:
undetectable		 6brdB-3pk0A:
18.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rih SHORT CHAIN
DEHYDROGENASE OR
REDUCTASE

(Mycobacteroides
abscessus) 		PF13561
(adh_short_C2) 		4 GLN A 137
VAL A  78
LEU A 188
ARG A 150
 EDO  A 278 (-3.8A)
None
None
None
 1.33A 6brdB-3rihA:
undetectable		 6brdB-3rihA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3t05 PYRUVATE KINASE

(Staphylococcus
aureus) 		PF00224
(PK)
PF00391
(PEP-utilizers)
PF02887
(PK_C) 		4 VAL A   7
LEU A 233
ARG A 204
PRO A 218
 None
 1.14A 6brdB-3t05A:
undetectable		 6brdB-3t05A:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3thw DNA MISMATCH REPAIR
PROTEIN MSH3

(Homo sapiens) 		PF00488
(MutS_V)
PF01624
(MutS_I)
PF05188
(MutS_II)
PF05192
(MutS_III) 		4 GLN B 899
VAL B 857
LEU B 997
MET B 526
 None
 1.23A 6brdB-3thwB:
undetectable		 6brdB-3thwB:
6.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7v BETA-GALACTOSIDASE

(Caulobacter
vibrioides) 		PF02449
(Glyco_hydro_42) 		4 VAL A 123
LEU A 333
ARG A 338
PRO A 319
 None
 1.33A 6brdB-3u7vA:
undetectable		 6brdB-3u7vA:
9.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um6 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 GLN A 327
LEU A 369
ARG A 566
PRO A 568
 None
 1.24A 6brdB-3um6A:
undetectable		 6brdB-3um6A:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wwx S12 FAMILY PEPTIDASE

(Streptomyces
sp. 82F2) 		PF00144
(Beta-lactamase) 		4 GLN A  98
VAL A 206
LEU A 287
MET A 273
 None
 1.27A 6brdB-3wwxA:
0.1		 6brdB-3wwxA:
13.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zz1 BETA-D-GLUCOSIDE
GLUCOHYDROLASE

(Trichoderma
reesei) 		PF00933
(Glyco_hydro_3)
PF01915
(Glyco_hydro_3_C)
PF14310
(Fn3-like) 		4 VAL A 529
LEU A 514
ARG A 324
PRO A 506
 None
 1.19A 6brdB-3zz1A:
undetectable		 6brdB-3zz1A:
9.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a6u OMEGA TRANSAMINASE

(Chromobacterium
violaceum) 		PF00202
(Aminotran_3) 		4 GLN A 380
VAL A 236
LEU A 439
ARG A 366
 None
 1.14A 6brdB-4a6uA:
undetectable		 6brdB-4a6uA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a7w URIDYLATE KINASE

(Helicobacter
pylori) 		PF00696
(AA_kinase) 		4 VAL A 228
LEU A 125
MET A  90
ARG A 151
 None
 1.21A 6brdB-4a7wA:
undetectable		 6brdB-4a7wA:
22.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f1r CATABOLITE
REPRESSION CONTROL
PROTEIN

(Pseudomonas
aeruginosa) 		PF03372
(Exo_endo_phos) 		4 GLN A  96
VAL A  30
LEU A  83
ARG A  93
 None
 1.33A 6brdB-4f1rA:
undetectable		 6brdB-4f1rA:
14.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4i7u DIHYDRODIPICOLINATE
SYNTHASE

(Agrobacterium
sp. H13-3) 		PF00701
(DHDPS) 		4 GLN A  31
VAL A  73
LEU A 257
PRO A  12
 None
 1.24A 6brdB-4i7uA:
undetectable		 6brdB-4i7uA:
14.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jbb PUTATIVE GLUTATHIONE
S-TRANSFERASE

(Klebsiella
pneumoniae) 		PF13417
(GST_N_3)
PF14834
(GST_C_4) 		4 GLN A 196
VAL A  24
LEU A 153
ARG A 101
 None
 1.18A 6brdB-4jbbA:
undetectable		 6brdB-4jbbA:
21.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ldp NDP-FOROSAMYLTRANSFE
RASE

(Saccharopolyspora
spinosa) 		PF06722
(DUF1205) 		4 VAL A  53
LEU A 184
ARG A 149
PRO A 137
 None
 1.33A 6brdB-4ldpA:
undetectable		 6brdB-4ldpA:
11.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m8u OLIGO-1,6-GLUCOSIDAS
E 1

(Bacillus
subtilis) 		PF00128
(Alpha-amylase)
PF16657
(Malt_amylase_C) 		4 GLN A  12
VAL A 253
MET A  80
ARG A  90
 None
 1.25A 6brdB-4m8uA:
undetectable		 6brdB-4m8uA:
9.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mbg CAAX
FARNESYLTRANSFERASE
ALPHA SUBUNIT RAM2

(Aspergillus
fumigatus) 		PF01239
(PPTA) 		4 GLN A 235
VAL A 227
ARG A 245
PRO A 247
 None
 1.27A 6brdB-4mbgA:
undetectable		 6brdB-4mbgA:
13.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o38 CYCLIN-G-ASSOCIATED
KINASE

(Homo sapiens) 		PF00069
(Pkinase) 		4 GLN A 154
VAL A 322
LEU A 179
MET A 295
 None
 1.29A 6brdB-4o38A:
undetectable		 6brdB-4o38A:
11.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o99 ACETYL-COA
ACETYLTRANSFERASE

(Cupriavidus
necator) 		PF00108
(Thiolase_N)
PF02803
(Thiolase_C) 		4 GLN A  55
LEU A  29
ARG A  11
PRO A 350
 None
 1.31A 6brdB-4o99A:
undetectable		 6brdB-4o99A:
12.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pii N-GLYCOSYLASE/DNA
LYASE

(Pyrococcus
furiosus) 		PF09171
(AGOG) 		4 VAL A 204
LEU A 222
ARG A  25
PRO A 215
 None
 1.27A 6brdB-4piiA:
undetectable		 6brdB-4piiA:
13.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rcn LONG-CHAIN ACYL-COA
CARBOXYLASE

(Mycobacterium
avium) 		PF00289
(Biotin_carb_N)
PF01039
(Carboxyl_trans)
PF02785
(Biotin_carb_C)
PF02786
(CPSase_L_D2) 		4 GLN A 825
VAL A 767
LEU A 834
PRO A 894
 None
 1.05A 6brdB-4rcnA:
undetectable		 6brdB-4rcnA:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rh7 GREEN FLUORESCENT
PROTEIN/CYTOPLASMIC
DYNEIN 2 HEAVY CHAIN
1

(Homo sapiens;
synthetic
construct) 		PF03028
(Dynein_heavy)
PF07728
(AAA_5)
PF08393
(DHC_N2)
PF12774
(AAA_6)
PF12775
(AAA_7)
PF12777
(MT)
PF12780
(AAA_8)
PF12781
(AAA_9) 		4 VAL A1484
LEU A1705
MET A1634
ARG A1708
 None
 1.24A 6brdB-4rh7A:
undetectable		 6brdB-4rh7A:
2.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tx2 NON-RIBOSOMAL
PEPTIDE SYNTHETASE

(Actinoplanes
teichomyceticus) 		PF00668
(Condensation) 		4 GLN B 264
VAL B 365
LEU B 312
ARG B 273
 None
 1.28A 6brdB-4tx2B:
1.3		 6brdB-4tx2B:
11.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgt FRQ-INTERACTING RNA
HELICASE

(Neurospora
crassa) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF08148
(DSHCT)
PF13234
(rRNA_proc-arch) 		4 GLN A 185
VAL A 200
ARG A 175
PRO A 173
 None
 1.21A 6brdB-4xgtA:
undetectable		 6brdB-4xgtA:
5.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xsc THYMIDYLATE SYNTHASE

(Human
alphaherpesvirus
3) 		PF00303
(Thymidylat_synt) 		4 GLN A  20
LEU A  62
ARG A 259
PRO A 261
 None
 1.31A 6brdB-4xscA:
undetectable		 6brdB-4xscA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bxi NUCLEOSIDE
DIPHOSPHATE KINASE

(Toxoplasma
gondii) 		PF00334
(NDK) 		4 GLN A  32
VAL A 152
LEU A 106
ARG A  90
 None
None
None
BCT  A 201 ( 4.9A)
 1.17A 6brdB-5bxiA:
undetectable		 6brdB-5bxiA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gw5 T-COMPLEX PROTEIN 1
SUBUNIT ALPHA

(Saccharomyces
cerevisiae) 		PF00118
(Cpn60_TCP1) 		4 VAL a 517
LEU a 455
ARG a 478
PRO a 459
 None
 1.28A 6brdB-5gw5a:
undetectable		 6brdB-5gw5a:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h3a ORF70

(Human
gammaherpesvirus
8) 		PF00303
(Thymidylat_synt) 		4 GLN A  56
LEU A  98
ARG A 295
PRO A 297
 None
 1.15A 6brdB-5h3aA:
undetectable		 6brdB-5h3aA:
15.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k5z PARA

(Sulfolobus sp.
NOB8H2) 		PF13614
(AAA_31) 		4 GLN A  48
LEU A  60
MET A 111
PRO A 101
 None
 1.20A 6brdB-5k5zA:
undetectable		 6brdB-5k5zA:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k9n POLYAMINE N
ACETYLTRANSFERASE

(Drosophila
melanogaster) 		PF00583
(Acetyltransf_1) 		4 GLN A 210
VAL A 110
MET A 147
PRO A  35
 None
 1.28A 6brdB-5k9nA:
undetectable		 6brdB-5k9nA:
18.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5koh NITROGENASE FEMO
BETA SUBUNIT PROTEIN
NIFK

(Gluconacetobacter
diazotrophicus) 		PF00148
(Oxidored_nitro)
PF11844
(DUF3364) 		4 VAL B 472
LEU B  72
ARG B 104
PRO B 460
 None
 1.30A 6brdB-5kohB:
undetectable		 6brdB-5kohB:
9.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kyu PROTEIN TRANSPORT
PROTEIN SEC24D

(Homo sapiens) 		PF00626
(Gelsolin)
PF04810
(zf-Sec23_Sec24)
PF04811
(Sec23_trunk)
PF04815
(Sec23_helical)
PF08033
(Sec23_BS) 		4 GLN B 653
VAL B 633
LEU B 799
PRO B 614
 None
 1.18A 6brdB-5kyuB:
undetectable		 6brdB-5kyuB:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nn8 LYSOSOMAL
ALPHA-GLUCOSIDASE

(Homo sapiens) 		no annotation 4 GLN A 553
VAL A 547
LEU A 476
PRO A 522
 None
 1.29A 6brdB-5nn8A:
undetectable		 6brdB-5nn8A:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o9w THEBAINE
6-O-DEMETHYLASE

(Papaver
somniferum) 		no annotation 4 VAL A 299
LEU A   9
MET A 115
PRO A  30
 None
 1.22A 6brdB-5o9wA:
undetectable		 6brdB-5o9wA:
20.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t0l BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Toxoplasma
gondii) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 GLN A 326
LEU A 368
ARG A 566
PRO A 568
 None
 1.13A 6brdB-5t0lA:
undetectable		 6brdB-5t0lA:
8.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ty0 ELONGATION FACTOR G

(Legionella
pneumophila) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2) 		4 VAL A 180
LEU A 284
ARG A 135
PRO A 261
 None
 1.20A 6brdB-5ty0A:
undetectable		 6brdB-5ty0A:
11.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vef SERINE/THREONINE-PRO
TEIN KINASE PAK 4

(Homo sapiens) 		no annotation 4 VAL A 476
LEU A 308
MET A 395
ARG A 371
 SEP  A 474 ( 4.4A)
None
M77  A 601 ( 2.9A)
None
 0.99A 6brdB-5vefA:
1.2		 6brdB-5vefA:
13.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgl SOLUBLE
ACETYLCHOLINE
RECEPTOR

(Aplysia
californica) 		no annotation 4 VAL A  97
LEU A 154
ARG A  57
PRO A  86
 None
 1.26A 6brdB-5xglA:
undetectable		 6brdB-5xglA:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xgl SOLUBLE
ACETYLCHOLINE
RECEPTOR

(Aplysia
californica) 		no annotation 4 VAL A  99
LEU A 154
ARG A  57
PRO A  86
 None
 1.17A 6brdB-5xglA:
undetectable		 6brdB-5xglA:
18.39
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6c7s PUTATIVE RIFAMPIN
MONOOXYGENASE

(Nocardia
farcinica) 		no annotation 4 VAL A  93
LEU A 176
ARG A 201
PRO A 283
 None
FAD  A 501 ( 4.6A)
None
RFH  A 502 ( 4.2A)
 0.53A 6brdB-6c7sA:
63.3		 6brdB-6c7sA:
74.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d6u GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
BETA-2,GAMMA-AMINOBU
TYRIC ACID RECEPTOR
SUBUNIT BETA-2
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
GAMMA-2,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT GAMMA-2

(Homo sapiens) 		no annotation 4 VAL A  16
LEU E  87
ARG E  85
PRO E  44
 None
 1.27A 6brdB-6d6uA:
undetectable		 6brdB-6d6uA:
14.46