SIMILAR PATTERNS OF AMINO ACIDS FOR 6BQG_A_ERMA1201_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site

Query pattern: Residues from known binding site for annotated drug that match the hit pattern


(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism
Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1civ NADP-MALATE
DEHYDROGENASE


(Flaveria
bidentis)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 SER A  81
VAL A 167
ALA A  87
SER A 275
GLU A 384
NAP  A 386 (-3.0A)
NAP  A 386 (-4.7A)
None
NAP  A 386 ( 4.6A)
NAP  A 386 (-3.9A)
1.14A 6bqgA-1civA:
undetectable
6bqgA-1civA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1di6 MOLYBDENUM COFACTOR
BIOSYNTHETIC ENZYME


(Escherichia
coli)
PF00994
(MoCF_biosynth)
5 VAL A  91
VAL A 120
GLY A 100
ASN A 131
VAL A  70
None
1.18A 6bqgA-1di6A:
undetectable
6bqgA-1di6A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz7 LIPASE 2

(Diutina rugosa)
PF00135
(COesterase)
5 SER A 241
VAL A  81
GLY A 123
ALA A 210
PHE A 345
None
1.18A 6bqgA-1gz7A:
undetectable
6bqgA-1gz7A:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hk7 HEAT SHOCK PROTEIN
HSP82


(Saccharomyces
cerevisiae)
PF00183
(HSP90)
5 VAL A 365
ALA A 327
PHE A 417
GLU A 402
ASN A 405
None
0.95A 6bqgA-1hk7A:
undetectable
6bqgA-1hk7A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iy8 LEVODIONE REDUCTASE

(Leifsonia
aquatica)
PF13561
(adh_short_C2)
5 GLY A  24
ALA A  28
PHE A  97
ASN A  99
VAL A 148
NAD  A1268 (-3.3A)
None
None
NAD  A1268 (-3.3A)
None
1.12A 6bqgA-1iy8A:
0.6
6bqgA-1iy8A:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmz AMINE DEHYDROGENASE

(Pseudomonas
putida)
no annotation 5 ASP B  66
VAL B  59
GLY B 135
ASN B  77
ASN B  21
None
1.18A 6bqgA-1jmzB:
undetectable
6bqgA-1jmzB:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luj CATENIN BETA-1

(Homo sapiens)
PF00514
(Arm)
5 GLY A 319
ALA A 323
ASN A 353
SER A 352
VAL A 346
None
0.94A 6bqgA-1lujA:
undetectable
6bqgA-1lujA:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9i MANGANESE CATALASE

(Lactobacillus
plantarum)
PF05067
(Mn_catalase)
5 SER A 134
VAL A 145
GLY A  46
ALA A  48
GLU A 190
None
1.21A 6bqgA-1o9iA:
2.6
6bqgA-1o9iA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oxj RNA-BINDING PROTEIN
SMAUG


(Drosophila
melanogaster)
PF00536
(SAM_1)
PF09246
(PHAT)
5 VAL A 732
VAL A 713
PHE A 706
GLU A 679
VAL A 685
None
1.06A 6bqgA-1oxjA:
undetectable
6bqgA-1oxjA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r1a HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP3)


(Rhinovirus A)
PF00073
(Rhv)
5 VAL 3  55
GLY 3 187
ALA 3 186
PHE 3 115
VAL 3 213
None
1.19A 6bqgA-1r1a3:
undetectable
6bqgA-1r1a3:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE


(Escherichia
coli)
PF00202
(Aminotran_3)
5 VAL A 241
GLY A 244
ALA A 253
GLU A 116
VAL A 204
PMP  A1271 ( 4.1A)
None
None
None
None
1.12A 6bqgA-1szsA:
undetectable
6bqgA-1szsA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0b THUA-LIKE PROTEIN

(Geobacillus
stearothermophilus)
PF06283
(ThuA)
5 VAL A 210
ALA A 217
PHE A 169
GLU A 148
VAL A 132
None
1.13A 6bqgA-1t0bA:
undetectable
6bqgA-1t0bA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE


(Mycobacterium
tuberculosis)
PF13561
(adh_short_C2)
5 GLY A  26
ALA A  30
ASN A  24
SER A  49
GLU A  59
NAP  A1249 (-3.4A)
None
NAP  A1249 (-3.3A)
NAP  A1249 ( 4.4A)
None
1.17A 6bqgA-1uznA:
undetectable
6bqgA-1uznA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wiu TWITCHIN 18TH IGSF
MODULE


(Caenorhabditis
elegans)
PF07679
(I-set)
5 ASP A  69
GLY A  39
ALA A  43
GLU A  23
ASN A  21
None
1.17A 6bqgA-1wiuA:
undetectable
6bqgA-1wiuA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfi UNKNOWN PROTEIN

(Arabidopsis
thaliana)
PF01937
(DUF89)
5 VAL A 301
GLY A 290
PHE A 218
SER A 309
VAL A 317
None
1.12A 6bqgA-1xfiA:
2.6
6bqgA-1xfiA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xi6 EXTRAGENIC
SUPPRESSOR


(Pyrococcus
furiosus)
PF00459
(Inositol_P)
6 SER A 153
VAL A 142
GLY A 186
ALA A 187
ASN A 241
GLU A 243
None
1.49A 6bqgA-1xi6A:
undetectable
6bqgA-1xi6A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytk NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE FROM
THERMOPLASMA
ACIDOPHILUM


(Thermoplasma
acidophilum)
PF01729
(QRPTase_C)
5 GLY A  56
ALA A 116
PHE A 303
GLU A  41
VAL A  44
None
1.13A 6bqgA-1ytkA:
undetectable
6bqgA-1ytkA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cg9 ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82


(Saccharomyces
cerevisiae)
PF00183
(HSP90)
PF02518
(HATPase_c)
5 VAL A 365
ALA A 327
PHE A 417
GLU A 402
ASN A 405
None
1.02A 6bqgA-2cg9A:
undetectable
6bqgA-2cg9A:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cge ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82


(Saccharomyces
cerevisiae)
PF00183
(HSP90)
5 VAL A 365
ALA A 327
PHE A 417
GLU A 402
ASN A 405
None
1.00A 6bqgA-2cgeA:
2.3
6bqgA-2cgeA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0p ENDOGLUCANASE

(Ruminiclostridium
thermocellum)
PF12891
(Glyco_hydro_44)
5 GLY A 370
ALA A 373
PHE A 391
ASN A 397
SER A 396
None
1.14A 6bqgA-2e0pA:
undetectable
6bqgA-2e0pA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e54 ACETYLORNITHINE
AMINOTRANSFERASE


(Thermotoga
maritima)
PF00202
(Aminotran_3)
5 VAL A 375
VAL A 350
ALA A 353
PHE A 330
VAL A 316
None
None
None
None
NA  A1004 (-4.4A)
1.20A 6bqgA-2e54A:
undetectable
6bqgA-2e54A:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9t PANTOTHENATE KINASE

(Pseudomonas
aeruginosa)
PF03309
(Pan_kinase)
5 SER A  81
VAL A 237
GLY A 240
ALA A 244
ASN A   9
None
1.08A 6bqgA-2f9tA:
undetectable
6bqgA-2f9tA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6e D-ARABINOSE
1-DEHYDROGENASE


(Sulfolobus
solfataricus)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 SER A 276
VAL A 246
GLY A 269
ASN A 177
GLU A 222
None
1.13A 6bqgA-2h6eA:
undetectable
6bqgA-2h6eA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnh DNA POLYMERASE III
ALPHA SUBUNIT


(Escherichia
coli)
PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6)
5 VAL A 404
GLY A 361
ALA A 763
SER A 351
GLU A 346
None
1.11A 6bqgA-2hnhA:
undetectable
6bqgA-2hnhA:
7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iz7 MOCO CARRIER PROTEIN

(Chlamydomonas
reinhardtii)
no annotation 5 VAL A 153
GLY A 155
ALA A 159
GLU A  52
VAL A  10
None
1.16A 6bqgA-2iz7A:
undetectable
6bqgA-2iz7A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ji9 OXALYL-COA
DECARBOXYLASE


(Oxalobacter
formigenes)
PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N)
5 VAL A 330
VAL A 237
GLY A 241
ALA A 343
VAL A 303
None
1.14A 6bqgA-2ji9A:
undetectable
6bqgA-2ji9A:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jir PERIPLASMIC NITRATE
REDUCTASE


(Desulfovibrio
desulfuricans)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4)
5 GLY A 356
ALA A 358
GLU A 518
ASN A 516
VAL A 495
None
1.04A 6bqgA-2jirA:
undetectable
6bqgA-2jirA:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjf L-LYSINE EPSILON
AMINOTRANSFERASE


(Mycobacterium
tuberculosis)
PF00202
(Aminotran_3)
5 VAL A 273
GLY A 276
ALA A 285
GLU A 133
VAL A 236
None
1.00A 6bqgA-2jjfA:
undetectable
6bqgA-2jjfA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pb0 ACETYLORNITHINE/SUCC
INYLDIAMINOPIMELATE
AMINOTRANSFERASE


(Salmonella
enterica)
PF00202
(Aminotran_3)
5 VAL A 228
GLY A 231
ALA A 240
GLU A 113
VAL A 191
PLP  A 555 (-4.3A)
None
None
None
None
1.11A 6bqgA-2pb0A:
undetectable
6bqgA-2pb0A:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pwz MALATE DEHYDROGENASE

(Escherichia
coli)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 SER A  31
GLY A  13
ALA A   8
GLU A 250
VAL A  72
None
1.20A 6bqgA-2pwzA:
undetectable
6bqgA-2pwzA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvp UNCHARACTERIZED
PROTEIN


(Shewanella
amazonensis)
PF04952
(AstE_AspA)
5 ALA A 237
PHE A 265
SER A 243
ASN A 263
VAL A 266
None
1.12A 6bqgA-2qvpA:
undetectable
6bqgA-2qvpA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vcy TRANS-2-ENOYL-COA
REDUCTASE


(Homo sapiens)
PF00107
(ADH_zinc_N)
PF08240
(ADH_N)
5 VAL A 196
GLY A 108
ALA A  79
ASN A  83
SER A  85
None
None
None
SO4  A1377 ( 4.9A)
None
1.15A 6bqgA-2vcyA:
undetectable
6bqgA-2vcyA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vn7 GLUCOAMYLASE

(Trichoderma
reesei)
PF00686
(CBM_20)
PF00723
(Glyco_hydro_15)
5 SER A 252
GLY A 308
ALA A 324
SER A 291
VAL A 284
None
1.19A 6bqgA-2vn7A:
3.6
6bqgA-2vn7A:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5f ENDO-1,4-BETA-XYLANA
SE Y


(Ruminiclostridium
thermocellum)
PF00331
(Glyco_hydro_10)
PF02018
(CBM_4_9)
5 SER A 118
VAL A  37
GLY A  93
ALA A 155
ASN A 264
None
1.10A 6bqgA-2w5fA:
undetectable
6bqgA-2w5fA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5d PROBABLE
AMINOTRANSFERASE


(Pseudomonas
aeruginosa)
PF00155
(Aminotran_1_2)
5 ASP A 370
GLY A 363
ASN A 129
SER A 148
VAL A 152
None
0.86A 6bqgA-2x5dA:
undetectable
6bqgA-2x5dA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjq CEL44C

(Paenibacillus
polymyxa)
PF12891
(Glyco_hydro_44)
5 ASP A 282
GLY A  29
ALA A  42
ASN A  31
ASN A  48
None
None
None
None
OXZ  A1518 (-3.5A)
1.15A 6bqgA-2yjqA:
undetectable
6bqgA-2yjqA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2b DIHYDROOROTASE

(Escherichia
coli)
PF01979
(Amidohydro_1)
5 VAL A 235
PHE A 272
SER A 230
GLU A 226
VAL A 271
None
1.01A 6bqgA-2z2bA:
undetectable
6bqgA-2z2bA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6h CATENIN BETA-1

(Homo sapiens)
PF00514
(Arm)
5 GLY A 319
ALA A 323
ASN A 353
SER A 352
VAL A 346
None
0.88A 6bqgA-2z6hA:
undetectable
6bqgA-2z6hA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ztu D(-)-3-HYDROXYBUTYRA
TE DEHYDROGENASE


(Pseudomonas
fragi)
PF13561
(adh_short_C2)
5 VAL A  45
GLY A  48
ALA A  50
ASN A  90
VAL A   9
None
None
None
NAD  A 300 (-3.2A)
None
1.12A 6bqgA-2ztuA:
undetectable
6bqgA-2ztuA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bb9 PUTATIVE ORPHAN
PROTEIN


(Shewanella
frigidimarina)
PF13474
(SnoaL_3)
5 SER A 108
VAL A  50
VAL A  34
GLY A  32
VAL A 144
None
1.14A 6bqgA-3bb9A:
undetectable
6bqgA-3bb9A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e74 ALLANTOINASE

(Escherichia
coli)
PF01979
(Amidohydro_1)
5 VAL A 431
GLY A 429
ALA A 386
PHE A 390
GLU A 436
None
1.08A 6bqgA-3e74A:
undetectable
6bqgA-3e74A:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efe THIJ/PFPI FAMILY
PROTEIN


(Bacillus
anthracis)
PF01965
(DJ-1_PfpI)
5 GLY A  80
ALA A 112
PHE A 170
GLU A  25
VAL A 174
None
1.19A 6bqgA-3efeA:
undetectable
6bqgA-3efeA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN


(Escherichia
coli)
PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N)
5 ASP A 263
SER A 240
VAL A 578
ALA A 575
ASN A 798
None
None
MGD  A1246 (-3.9A)
None
None
1.19A 6bqgA-3egwA:
undetectable
6bqgA-3egwA:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqn GLUCAN
1,3-BETA-GLUCOSIDASE


(Phanerochaete
chrysosporium)
PF12708
(Pectate_lyase_3)
5 SER A 609
VAL A 668
VAL A 676
GLY A 628
PHE A 681
None
1.20A 6bqgA-3eqnA:
undetectable
6bqgA-3eqnA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euk CHROMOSOME PARTITION
PROTEIN MUKE


([Haemophilus]
ducreyi)
PF04288
(MukE)
5 VAL L  97
VAL L 154
GLY L 156
PHE L 178
GLU L 122
None
1.20A 6bqgA-3eukL:
undetectable
6bqgA-3eukL:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fqd 5'-3'
EXORIBONUCLEASE 2


(Schizosaccharomyces
pombe)
PF03159
(XRN_N)
5 VAL A 327
VAL A 624
GLY A 620
ASN A 335
VAL A 333
None
1.18A 6bqgA-3fqdA:
undetectable
6bqgA-3fqdA:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdf PROBABLE
NADP-DEPENDENT
MANNITOL
DEHYDROGENASE


(Cladosporium
herbarum)
PF13561
(adh_short_C2)
5 GLY A  27
ALA A  28
SER A  87
GLU A  89
VAL A  95
None
1.17A 6bqgA-3gdfA:
undetectable
6bqgA-3gdfA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ik2 ENDOGLUCANASE A

(Clostridium
acetobutylicum)
PF12891
(Glyco_hydro_44)
5 ASP A 275
GLY A  22
ALA A  34
ASN A  24
ASN A  40
None
1.19A 6bqgA-3ik2A:
undetectable
6bqgA-3ik2A:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nbh RECQ-MEDIATED GENOME
INSTABILITY PROTEIN
2


(Homo sapiens)
PF16100
(RMI2)
6 VAL B 139
VAL B  58
GLY B 106
ALA B 119
PHE B  81
GLU B  28
None
1.32A 6bqgA-3nbhB:
undetectable
6bqgA-3nbhB:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oks 4-AMINOBUTYRATE
TRANSAMINASE


(Mycolicibacterium
smegmatis)
PF00202
(Aminotran_3)
5 VAL A 265
GLY A 268
ALA A 277
GLU A 132
VAL A 228
LLP  A 292 ( 4.2A)
None
None
None
None
1.13A 6bqgA-3oksA:
undetectable
6bqgA-3oksA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqn CATABOLITE CONTROL
PROTEIN A


(Bacillus
subtilis)
PF00356
(LacI)
PF13377
(Peripla_BP_3)
5 VAL A  52
GLY A  55
ALA A  57
ASN A  50
ASN A   3
None
1.17A 6bqgA-3oqnA:
undetectable
6bqgA-3oqnA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4c HYDROLASE, HALOACID
DEHALOGENASE-LIKE
HYDROLASE


(Bacteroides
thetaiotaomicron)
PF08282
(Hydrolase_3)
5 VAL A   9
VAL A 243
GLY A 247
GLU A  52
VAL A  56
SO4  A 260 (-3.7A)
None
None
None
None
1.08A 6bqgA-3r4cA:
undetectable
6bqgA-3r4cA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rre PUTATIVE
UNCHARACTERIZED
PROTEIN


(Thermotoga
maritima)
PF01256
(Carb_kinase)
PF03853
(YjeF_N)
5 VAL A  58
GLY A  56
ALA A 115
PHE A 172
ASN A 195
None
None
None
GOL  A 496 ( 4.7A)
None
1.16A 6bqgA-3rreA:
undetectable
6bqgA-3rreA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tcl CH04 HEAVY CHAIN FAB

(Homo sapiens)
no annotation 5 VAL H 211
GLY H 157
ALA H 158
SER H 180
VAL H 184
None
1.01A 6bqgA-3tclH:
undetectable
6bqgA-3tclH:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v10 RHUSIOPATHIAE
SURFACE PROTEIN B


(Erysipelothrix
rhusiopathiae)
PF05737
(Collagen_bind)
5 VAL A  72
GLY A 344
ALA A 106
PHE A 130
GLU A  36
None
0.97A 6bqgA-3v10A:
undetectable
6bqgA-3v10A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zrp SERINE-PYRUVATE
AMINOTRANSFERASE
(AGXT)


(Sulfolobus
solfataricus)
PF00266
(Aminotran_5)
6 SER A 203
VAL A 173
GLY A  49
ALA A  50
SER A 167
VAL A 161
None
1.48A 6bqgA-3zrpA:
undetectable
6bqgA-3zrpA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crm TRANSLATION
INITIATION FACTOR
RLI1


(Saccharomyces
cerevisiae)
PF00005
(ABC_tran)
PF00037
(Fer4)
PF04068
(RLI)
5 SER P 249
VAL P 524
GLY P 224
ASN P 387
VAL P 254
None
None
None
ADP  P1612 (-3.6A)
None
1.10A 6bqgA-4crmP:
undetectable
6bqgA-4crmP:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecm GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E


(Bacillus
anthracis)
PF00483
(NTP_transferase)
5 VAL A  79
GLY A 107
ALA A  37
GLU A  56
VAL A  62
None
DAU  A 301 ( 4.0A)
None
None
None
1.18A 6bqgA-4ecmA:
undetectable
6bqgA-4ecmA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ee8 PRENYLTRANSFERASE

(Streptomyces
cinnamonensis)
PF11468
(PTase_Orf2)
5 GLY A 192
ALA A 195
PHE A 233
SER A 216
VAL A 221
None
0.99A 6bqgA-4ee8A:
undetectable
6bqgA-4ee8A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ee8 PRENYLTRANSFERASE

(Streptomyces
cinnamonensis)
PF11468
(PTase_Orf2)
5 VAL A 187
GLY A 192
ALA A 195
PHE A 233
VAL A 221
None
1.16A 6bqgA-4ee8A:
undetectable
6bqgA-4ee8A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgs PROBABLE
DEHYDROGENASE
PROTEIN


(Rhizobium etli)
PF13561
(adh_short_C2)
5 GLY A  18
ALA A  22
PHE A  86
ASN A  88
VAL A 134
None
1.17A 6bqgA-4fgsA:
undetectable
6bqgA-4fgsA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fn5 ELONGATION FACTOR G
1


(Pseudomonas
aeruginosa)
PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II)
5 VAL A 262
ALA A 109
PHE A 113
GLU A 156
VAL A 119
None
1.17A 6bqgA-4fn5A:
undetectable
6bqgA-4fn5A:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hcj THIJ/PFPI DOMAIN
PROTEIN


(Brachyspira
murdochii)
PF01965
(DJ-1_PfpI)
5 VAL A  73
GLY A 107
PHE A 162
GLU A  29
VAL A 166
None
1.10A 6bqgA-4hcjA:
undetectable
6bqgA-4hcjA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hnl MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME


(Enterococcus
gallinarum)
PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C)
5 ASP A   8
GLY A  34
ALA A  96
PHE A  12
GLU A 372
None
1.16A 6bqgA-4hnlA:
undetectable
6bqgA-4hnlA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hx6 OXIDOREDUCTASE

(Streptomyces
globisporus)
PF01613
(Flavin_Reduct)
5 SER A 118
VAL A  83
VAL A  59
GLY A 148
ALA A 133
None
1.11A 6bqgA-4hx6A:
undetectable
6bqgA-4hx6A:
19.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562


(Escherichia
coli;
Homo sapiens)
PF00001
(7tm_1)
PF07361
(Cytochrom_B562)
7 ASP A 135
SER A 139
GLY A 221
ALA A 225
PHE A 340
ASN A 344
VAL A 366
ERM  A2001 (-3.2A)
ERM  A2001 (-3.6A)
ERM  A2001 ( 4.3A)
ERM  A2001 (-3.4A)
ERM  A2001 (-4.3A)
ERM  A2001 (-4.3A)
ERM  A2001 ( 4.2A)
0.44A 6bqgA-4ib4A:
36.4
6bqgA-4ib4A:
62.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562


(Escherichia
coli;
Homo sapiens)
PF00001
(7tm_1)
PF07361
(Cytochrom_B562)
7 ASP A 135
SER A 139
VAL A 208
GLY A 221
ALA A 225
PHE A 340
VAL A 366
ERM  A2001 (-3.2A)
ERM  A2001 (-3.6A)
ERM  A2001 (-4.0A)
ERM  A2001 ( 4.3A)
ERM  A2001 (-3.4A)
ERM  A2001 (-4.3A)
ERM  A2001 ( 4.2A)
0.48A 6bqgA-4ib4A:
36.4
6bqgA-4ib4A:
62.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4keq 4-PYRIDOXOLACTONASE

(Mesorhizobium
japonicum)
PF00753
(Lactamase_B)
5 GLY A 103
PHE A  97
ASN A  94
GLU A 165
VAL A 120
None
None
None
None
GOL  A 305 (-3.8A)
1.08A 6bqgA-4keqA:
undetectable
6bqgA-4keqA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m62 T117

(synthetic
construct)
PF00359
(PTS_EIIA_2)
5 VAL S  88
VAL S  71
GLY S  63
ALA S 100
VAL S 126
None
0.98A 6bqgA-4m62S:
undetectable
6bqgA-4m62S:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mch URIDINE
PHOSPHORYLASE


(Aliivibrio
fischeri)
PF01048
(PNP_UDP_1)
5 ASP A 179
SER A 154
VAL A 105
GLY A 150
PHE A 186
None
1.14A 6bqgA-4mchA:
undetectable
6bqgA-4mchA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mch URIDINE
PHOSPHORYLASE


(Aliivibrio
fischeri)
PF01048
(PNP_UDP_1)
5 ASP A 179
VAL A  88
VAL A 105
GLY A 150
PHE A 186
None
1.18A 6bqgA-4mchA:
undetectable
6bqgA-4mchA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ni5 OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN


(Brucella suis)
PF13561
(adh_short_C2)
5 GLY A  16
ALA A  20
PHE A  86
ASN A  88
VAL A 136
None
1.14A 6bqgA-4ni5A:
undetectable
6bqgA-4ni5A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4om9 SERINE PROTEASE PET

(Escherichia
coli)
PF02395
(Peptidase_S6)
5 VAL A 477
GLY A 475
ALA A 445
GLU A 460
ASN A 437
None
1.18A 6bqgA-4om9A:
undetectable
6bqgA-4om9A:
6.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2i MKIAA0254 PROTEIN

(Mus musculus)
PF00787
(PX)
5 VAL A 611
GLY A 613
GLU A 650
ASN A 653
VAL A 657
None
1.13A 6bqgA-4p2iA:
2.3
6bqgA-4p2iA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p3i P DOMAIN OF VP1

(Norwalk virus)
PF00915
(Calici_coat)
PF08435
(Calici_coat_C)
5 VAL A 525
VAL A 427
PHE A 510
GLU A 482
ASN A 479
None
1.13A 6bqgA-4p3iA:
undetectable
6bqgA-4p3iA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pwy CALMODULIN-LYSINE
N-METHYLTRANSFERASE


(Homo sapiens)
PF10294
(Methyltransf_16)
5 VAL A 125
VAL A  89
GLY A  76
GLU A 132
ASN A  69
None
None
UNX  A 418 ( 3.5A)
UNX  A 420 ( 3.3A)
UNX  A 421 ( 3.9A)
1.14A 6bqgA-4pwyA:
undetectable
6bqgA-4pwyA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qme AMINOPEPTIDASE N

(Neisseria
meningitidis)
PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C)
5 GLY A 292
ALA A 229
PHE A 246
ASN A 265
ASN A 154
None
1.16A 6bqgA-4qmeA:
2.0
6bqgA-4qmeA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpy COMPLEMENT C1Q-LIKE
PROTEIN 2


(Mus musculus)
PF00386
(C1q)
5 VAL A  24
GLY A  21
ALA A 118
ASN A  33
VAL A  13
None
1.13A 6bqgA-4qpyA:
undetectable
6bqgA-4qpyA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2


(Yersinia pestis)
PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C)
5 VAL A 167
GLY A 171
ALA A 174
PHE A 409
VAL A 354
None
1.13A 6bqgA-4r8eA:
undetectable
6bqgA-4r8eA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rf3 NADPH DEPENDENT
R-SPECIFIC ALCOHOL
DEHYDROGENASE


(Lactobacillus
kefiri)
PF13561
(adh_short_C2)
5 GLY A 117
ALA A  64
ASN A 140
SER A 167
GLU A 242
None
1.20A 6bqgA-4rf3A:
undetectable
6bqgA-4rf3A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgk UNCHARACTERIZED
PROTEIN


(Yersinia pestis)
PF07350
(DUF1479)
5 VAL A  89
GLY A 329
ALA A 260
PHE A 333
ASN A 160
None
1.21A 6bqgA-4rgkA:
undetectable
6bqgA-4rgkA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxt SUGAR ABC
TRANSPORTER


(Agrobacterium
tumefaciens)
PF13407
(Peripla_BP_4)
5 SER A  46
VAL A 275
GLY A 237
ALA A 207
ASN A 139
None
1.11A 6bqgA-4rxtA:
undetectable
6bqgA-4rxtA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uup MALATE DEHYDROGENASE

(synthetic
construct)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 ASP A  81
VAL A  68
GLY A  66
ALA A  65
GLU A  74
None
1.20A 6bqgA-4uupA:
undetectable
6bqgA-4uupA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xaa PUTATIVE OXYGENASE

(Streptomyces
viridochromogenes)
PF05721
(PhyH)
5 VAL A 131
GLY A 158
PHE A  15
GLU A 213
VAL A 100
None
1.13A 6bqgA-4xaaA:
undetectable
6bqgA-4xaaA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A


(Thermotoga
maritima)
PF07992
(Pyr_redox_2)
PF14691
(Fer4_20)
5 VAL B 213
VAL B 229
ALA B 451
GLU B 402
ASN B 396
FAD  B 503 (-3.9A)
None
None
None
None
1.10A 6bqgA-4yryB:
1.4
6bqgA-4yryB:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zd6 HALOHYDRIN EPOXIDASE
B


(Corynebacterium
sp.)
PF13561
(adh_short_C2)
5 SER A 118
VAL A 188
GLY A 223
PHE A 170
GLU A 179
None
None
None
CL  A 301 (-4.8A)
None
1.09A 6bqgA-4zd6A:
undetectable
6bqgA-4zd6A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dte MONOSACCHARIDE-TRANS
PORTING ATPASE


(Actinobacillus
succinogenes)
PF13407
(Peripla_BP_4)
5 VAL A 261
VAL A 234
GLY A 232
ALA A 205
ASN A 150
None
1.12A 6bqgA-5dteA:
undetectable
6bqgA-5dteA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ep8 PYRIMIDINE-NUCLEOSID
E PHOSPHORYLASE


(Bacillus
subtilis)
PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C)
5 SER A 110
GLY A 192
ALA A 191
PHE A 139
ASN A 315
SER  A 110 (-0.0A)
GLY  A 192 ( 0.0A)
ALA  A 191 ( 0.0A)
PHE  A 139 ( 1.3A)
ASN  A 315 ( 0.6A)
1.19A 6bqgA-5ep8A:
undetectable
6bqgA-5ep8A:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqi SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 1


(Homo sapiens)
PF00083
(Sugar_tr)
5 VAL A 165
GLY A 167
ALA A 171
ASN A 317
VAL A 290
None
1.12A 6bqgA-5eqiA:
2.1
6bqgA-5eqiA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lu4 PYRUVATE, PHOSPHATE
DIKINASE,
CHLOROPLASTIC


(Flaveria
trinervia)
PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C)
5 GLY A 557
ALA A 555
SER A 767
GLU A 748
ASN A 771
None
None
None
MG  A 904 ( 2.7A)
PYR  A 903 (-3.8A)
1.05A 6bqgA-5lu4A:
undetectable
6bqgA-5lu4A:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE


(Homo sapiens)
PF00264
(Tyrosinase)
5 ASP A 212
SER A 214
ASN A 378
SER A 374
VAL A 391
None
None
0TR  A 513 ( 4.4A)
None
0TR  A 513 (-3.8A)
1.12A 6bqgA-5m8tA:
undetectable
6bqgA-5m8tA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdh MALATE DEHYDROGENASE

(Sus scrofa)
PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C)
5 SER A 152
VAL A  86
GLY A 129
ALA A 132
VAL A 253
None
NAD  A 334 (-4.5A)
NAD  A 334 (-3.6A)
NAD  A 334 ( 4.4A)
None
0.91A 6bqgA-5mdhA:
undetectable
6bqgA-5mdhA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1


(Synechocystis
sp. PCC 6803)
no annotation 5 ASP 1 589
SER 1 586
VAL 1 402
GLY 1 405
ALA 1 409
None
None
CLA  1 830 ( 4.7A)
BCR  1 848 ( 3.9A)
None
1.12A 6bqgA-5oy01:
1.7
6bqgA-5oy01:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
11
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2


(Homo sapiens)
no annotation 5 SER i 146
VAL V 141
ASN i 273
GLU i 268
VAL i 193
None
1.17A 6bqgA-5xtci:
2.4
6bqgA-5xtci:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z7r SHORT-CHAIN-ENOYL-CO
A HYDRATASE


(Clostridium
acetobutylicum)
no annotation 5 VAL A   6
VAL A  63
GLY A  65
PHE A  90
VAL A  89
None
1.03A 6bqgA-5z7rA:
undetectable
6bqgA-5z7rA:
24.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562


(Escherichia
coli;
Homo sapiens)
no annotation 9 ASP A 134
SER A 138
VAL A 208
VAL A 215
ALA A 222
PHE A 327
ASN A 331
ASN A 351
VAL A 354
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
None
E2J  A1201 (-4.6A)
E2J  A1201 ( 3.8A)
E2J  A1201 (-4.6A)
None
E2J  A1201 (-3.8A)
E2J  A1201 (-4.6A)
0.97A 6bqgA-6bqhA:
36.0
6bqgA-6bqhA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562


(Escherichia
coli;
Homo sapiens)
no annotation 9 ASP A 134
SER A 138
VAL A 208
VAL A 215
ALA A 222
PHE A 327
ASN A 331
GLU A 347
VAL A 354
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
None
E2J  A1201 (-4.6A)
E2J  A1201 ( 3.8A)
E2J  A1201 (-4.6A)
None
None
E2J  A1201 (-4.6A)
1.12A 6bqgA-6bqhA:
36.0
6bqgA-6bqhA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562


(Escherichia
coli;
Homo sapiens)
no annotation 7 ASP A 134
SER A 138
VAL A 208
VAL A 215
GLY A 218
ALA A 222
ASN A 351
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
None
E2J  A1201 (-4.6A)
E2J  A1201 (-3.1A)
E2J  A1201 ( 3.8A)
E2J  A1201 (-3.8A)
0.83A 6bqgA-6bqhA:
36.0
6bqgA-6bqhA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562


(Escherichia
coli;
Homo sapiens)
no annotation 7 ASP A 134
SER A 138
VAL A 208
VAL A 215
GLY A 218
ALA A 222
GLU A 347
E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
None
E2J  A1201 (-4.6A)
E2J  A1201 (-3.1A)
E2J  A1201 ( 3.8A)
None
1.03A 6bqgA-6bqhA:
36.0
6bqgA-6bqhA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eu6 AMMONIUM TRANSPORTER

(Candidatus
Kuenenia
stuttgartiensis)
no annotation 5 ASP A  50
VAL A 102
VAL A 170
GLY A 174
ALA A 178
NH4  A 505 (-2.8A)
None
None
None
None
1.04A 6bqgA-6eu6A:
2.0
6bqgA-6eu6A:
24.44