SIMILAR PATTERNS OF AMINO ACIDS FOR 6BQG_A_ERMA1201

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1civ NADP-MALATE
DEHYDROGENASE

(Flaveria
bidentis) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 SER A  81
VAL A 167
ALA A  87
SER A 275
GLU A 384
 NAP  A 386 (-3.0A)
NAP  A 386 (-4.7A)
None
NAP  A 386 ( 4.6A)
NAP  A 386 (-3.9A)
 1.14A 6bqgA-1civA:
undetectable		 6bqgA-1civA:
11.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1di6 MOLYBDENUM COFACTOR
BIOSYNTHETIC ENZYME

(Escherichia
coli) 		PF00994
(MoCF_biosynth) 		5 VAL A  91
VAL A 120
GLY A 100
ASN A 131
VAL A  70
 None
 1.18A 6bqgA-1di6A:
undetectable		 6bqgA-1di6A:
18.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gz7 LIPASE 2

(Diutina rugosa) 		PF00135
(COesterase) 		5 SER A 241
VAL A  81
GLY A 123
ALA A 210
PHE A 345
 None
 1.18A 6bqgA-1gz7A:
undetectable		 6bqgA-1gz7A:
9.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1hk7 HEAT SHOCK PROTEIN
HSP82

(Saccharomyces
cerevisiae) 		PF00183
(HSP90) 		5 VAL A 365
ALA A 327
PHE A 417
GLU A 402
ASN A 405
 None
 0.95A 6bqgA-1hk7A:
undetectable		 6bqgA-1hk7A:
15.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iy8 LEVODIONE REDUCTASE

(Leifsonia
aquatica) 		PF13561
(adh_short_C2) 		5 GLY A  24
ALA A  28
PHE A  97
ASN A  99
VAL A 148
 NAD  A1268 (-3.3A)
None
None
NAD  A1268 (-3.3A)
None
 1.12A 6bqgA-1iy8A:
0.6		 6bqgA-1iy8A:
15.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmz AMINE DEHYDROGENASE

(Pseudomonas
putida) 		no annotation 5 ASP B  66
VAL B  59
GLY B 135
ASN B  77
ASN B  21
 None
 1.18A 6bqgA-1jmzB:
undetectable		 6bqgA-1jmzB:
13.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1luj CATENIN BETA-1

(Homo sapiens) 		PF00514
(Arm) 		5 GLY A 319
ALA A 323
ASN A 353
SER A 352
VAL A 346
 None
 0.94A 6bqgA-1lujA:
undetectable		 6bqgA-1lujA:
9.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9i MANGANESE CATALASE

(Lactobacillus
plantarum) 		PF05067
(Mn_catalase) 		5 SER A 134
VAL A 145
GLY A  46
ALA A  48
GLU A 190
 None
 1.21A 6bqgA-1o9iA:
2.6		 6bqgA-1o9iA:
15.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1oxj RNA-BINDING PROTEIN
SMAUG

(Drosophila
melanogaster) 		PF00536
(SAM_1)
PF09246
(PHAT) 		5 VAL A 732
VAL A 713
PHE A 706
GLU A 679
VAL A 685
 None
 1.06A 6bqgA-1oxjA:
undetectable		 6bqgA-1oxjA:
16.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r1a HUMAN RHINOVIRUS 1A
COAT PROTEIN
(SUBUNIT VP3)

(Rhinovirus A) 		PF00073
(Rhv) 		5 VAL 3  55
GLY 3 187
ALA 3 186
PHE 3 115
VAL 3 213
 None
 1.19A 6bqgA-1r1a3:
undetectable		 6bqgA-1r1a3:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1szs 4-AMINOBUTYRATE
AMINOTRANSFERASE

(Escherichia
coli) 		PF00202
(Aminotran_3) 		5 VAL A 241
GLY A 244
ALA A 253
GLU A 116
VAL A 204
 PMP  A1271 ( 4.1A)
None
None
None
None
 1.12A 6bqgA-1szsA:
undetectable		 6bqgA-1szsA:
10.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t0b THUA-LIKE PROTEIN

(Geobacillus
stearothermophilus) 		PF06283
(ThuA) 		5 VAL A 210
ALA A 217
PHE A 169
GLU A 148
VAL A 132
 None
 1.13A 6bqgA-1t0bA:
undetectable		 6bqgA-1t0bA:
17.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1uzn 3-OXOACYL-[ACYL-CARR
IER PROTEIN]
REDUCTASE

(Mycobacterium
tuberculosis) 		PF13561
(adh_short_C2) 		5 GLY A  26
ALA A  30
ASN A  24
SER A  49
GLU A  59
 NAP  A1249 (-3.4A)
None
NAP  A1249 (-3.3A)
NAP  A1249 ( 4.4A)
None
 1.17A 6bqgA-1uznA:
undetectable		 6bqgA-1uznA:
16.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wiu TWITCHIN 18TH IGSF
MODULE

(Caenorhabditis
elegans) 		PF07679
(I-set) 		5 ASP A  69
GLY A  39
ALA A  43
GLU A  23
ASN A  21
 None
 1.17A 6bqgA-1wiuA:
undetectable		 6bqgA-1wiuA:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xfi UNKNOWN PROTEIN

(Arabidopsis
thaliana) 		PF01937
(DUF89) 		5 VAL A 301
GLY A 290
PHE A 218
SER A 309
VAL A 317
 None
 1.12A 6bqgA-1xfiA:
2.6		 6bqgA-1xfiA:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xi6 EXTRAGENIC
SUPPRESSOR

(Pyrococcus
furiosus) 		PF00459
(Inositol_P) 		6 SER A 153
VAL A 142
GLY A 186
ALA A 187
ASN A 241
GLU A 243
 None
 1.49A 6bqgA-1xi6A:
undetectable		 6bqgA-1xi6A:
13.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ytk NICOTINATE
PHOSPHORIBOSYLTRANSF
ERASE FROM
THERMOPLASMA
ACIDOPHILUM

(Thermoplasma
acidophilum) 		PF01729
(QRPTase_C) 		5 GLY A  56
ALA A 116
PHE A 303
GLU A  41
VAL A  44
 None
 1.13A 6bqgA-1ytkA:
undetectable		 6bqgA-1ytkA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cg9 ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82

(Saccharomyces
cerevisiae) 		PF00183
(HSP90)
PF02518
(HATPase_c) 		5 VAL A 365
ALA A 327
PHE A 417
GLU A 402
ASN A 405
 None
 1.02A 6bqgA-2cg9A:
undetectable		 6bqgA-2cg9A:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cge ATP-DEPENDENT
MOLECULAR CHAPERONE
HSP82

(Saccharomyces
cerevisiae) 		PF00183
(HSP90) 		5 VAL A 365
ALA A 327
PHE A 417
GLU A 402
ASN A 405
 None
 1.00A 6bqgA-2cgeA:
2.3		 6bqgA-2cgeA:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e0p ENDOGLUCANASE

(Ruminiclostridium
thermocellum) 		PF12891
(Glyco_hydro_44) 		5 GLY A 370
ALA A 373
PHE A 391
ASN A 397
SER A 396
 None
 1.14A 6bqgA-2e0pA:
undetectable		 6bqgA-2e0pA:
9.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e54 ACETYLORNITHINE
AMINOTRANSFERASE

(Thermotoga
maritima) 		PF00202
(Aminotran_3) 		5 VAL A 375
VAL A 350
ALA A 353
PHE A 330
VAL A 316
 None
None
None
None
NA  A1004 (-4.4A)
 1.20A 6bqgA-2e54A:
undetectable		 6bqgA-2e54A:
12.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9t PANTOTHENATE KINASE

(Pseudomonas
aeruginosa) 		PF03309
(Pan_kinase) 		5 SER A  81
VAL A 237
GLY A 240
ALA A 244
ASN A   9
 None
 1.08A 6bqgA-2f9tA:
undetectable		 6bqgA-2f9tA:
13.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h6e D-ARABINOSE
1-DEHYDROGENASE

(Sulfolobus
solfataricus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 SER A 276
VAL A 246
GLY A 269
ASN A 177
GLU A 222
 None
 1.13A 6bqgA-2h6eA:
undetectable		 6bqgA-2h6eA:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hnh DNA POLYMERASE III
ALPHA SUBUNIT

(Escherichia
coli) 		PF02811
(PHP)
PF07733
(DNA_pol3_alpha)
PF14579
(HHH_6) 		5 VAL A 404
GLY A 361
ALA A 763
SER A 351
GLU A 346
 None
 1.11A 6bqgA-2hnhA:
undetectable		 6bqgA-2hnhA:
7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2iz7 MOCO CARRIER PROTEIN

(Chlamydomonas
reinhardtii) 		no annotation 5 VAL A 153
GLY A 155
ALA A 159
GLU A  52
VAL A  10
 None
 1.16A 6bqgA-2iz7A:
undetectable		 6bqgA-2iz7A:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ji9 OXALYL-COA
DECARBOXYLASE

(Oxalobacter
formigenes) 		PF00205
(TPP_enzyme_M)
PF02775
(TPP_enzyme_C)
PF02776
(TPP_enzyme_N) 		5 VAL A 330
VAL A 237
GLY A 241
ALA A 343
VAL A 303
 None
 1.14A 6bqgA-2ji9A:
undetectable		 6bqgA-2ji9A:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jir PERIPLASMIC NITRATE
REDUCTASE

(Desulfovibrio
desulfuricans) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF04879
(Molybdop_Fe4S4) 		5 GLY A 356
ALA A 358
GLU A 518
ASN A 516
VAL A 495
 None
 1.04A 6bqgA-2jirA:
undetectable		 6bqgA-2jirA:
7.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jjf L-LYSINE EPSILON
AMINOTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00202
(Aminotran_3) 		5 VAL A 273
GLY A 276
ALA A 285
GLU A 133
VAL A 236
 None
 1.00A 6bqgA-2jjfA:
undetectable		 6bqgA-2jjfA:
10.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pb0 ACETYLORNITHINE/SUCC
INYLDIAMINOPIMELATE
AMINOTRANSFERASE

(Salmonella
enterica) 		PF00202
(Aminotran_3) 		5 VAL A 228
GLY A 231
ALA A 240
GLU A 113
VAL A 191
 PLP  A 555 (-4.3A)
None
None
None
None
 1.11A 6bqgA-2pb0A:
undetectable		 6bqgA-2pb0A:
9.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pwz MALATE DEHYDROGENASE

(Escherichia
coli) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 SER A  31
GLY A  13
ALA A   8
GLU A 250
VAL A  72
 None
 1.20A 6bqgA-2pwzA:
undetectable		 6bqgA-2pwzA:
14.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qvp UNCHARACTERIZED
PROTEIN

(Shewanella
amazonensis) 		PF04952
(AstE_AspA) 		5 ALA A 237
PHE A 265
SER A 243
ASN A 263
VAL A 266
 None
 1.12A 6bqgA-2qvpA:
undetectable		 6bqgA-2qvpA:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vcy TRANS-2-ENOYL-COA
REDUCTASE

(Homo sapiens) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 VAL A 196
GLY A 108
ALA A  79
ASN A  83
SER A  85
 None
None
None
SO4  A1377 ( 4.9A)
None
 1.15A 6bqgA-2vcyA:
undetectable		 6bqgA-2vcyA:
11.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vn7 GLUCOAMYLASE

(Trichoderma
reesei) 		PF00686
(CBM_20)
PF00723
(Glyco_hydro_15) 		5 SER A 252
GLY A 308
ALA A 324
SER A 291
VAL A 284
 None
 1.19A 6bqgA-2vn7A:
3.6		 6bqgA-2vn7A:
9.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w5f ENDO-1,4-BETA-XYLANA
SE Y

(Ruminiclostridium
thermocellum) 		PF00331
(Glyco_hydro_10)
PF02018
(CBM_4_9) 		5 SER A 118
VAL A  37
GLY A  93
ALA A 155
ASN A 264
 None
 1.10A 6bqgA-2w5fA:
undetectable		 6bqgA-2w5fA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x5d PROBABLE
AMINOTRANSFERASE

(Pseudomonas
aeruginosa) 		PF00155
(Aminotran_1_2) 		5 ASP A 370
GLY A 363
ASN A 129
SER A 148
VAL A 152
 None
 0.86A 6bqgA-2x5dA:
undetectable		 6bqgA-2x5dA:
12.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yjq CEL44C

(Paenibacillus
polymyxa) 		PF12891
(Glyco_hydro_44) 		5 ASP A 282
GLY A  29
ALA A  42
ASN A  31
ASN A  48
 None
None
None
None
OXZ  A1518 (-3.5A)
 1.15A 6bqgA-2yjqA:
undetectable		 6bqgA-2yjqA:
10.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z2b DIHYDROOROTASE

(Escherichia
coli) 		PF01979
(Amidohydro_1) 		5 VAL A 235
PHE A 272
SER A 230
GLU A 226
VAL A 271
 None
 1.01A 6bqgA-2z2bA:
undetectable		 6bqgA-2z2bA:
14.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2z6h CATENIN BETA-1

(Homo sapiens) 		PF00514
(Arm) 		5 GLY A 319
ALA A 323
ASN A 353
SER A 352
VAL A 346
 None
 0.88A 6bqgA-2z6hA:
undetectable		 6bqgA-2z6hA:
8.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ztu D(-)-3-HYDROXYBUTYRA
TE DEHYDROGENASE

(Pseudomonas
fragi) 		PF13561
(adh_short_C2) 		5 VAL A  45
GLY A  48
ALA A  50
ASN A  90
VAL A   9
 None
None
None
NAD  A 300 (-3.2A)
None
 1.12A 6bqgA-2ztuA:
undetectable		 6bqgA-2ztuA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bb9 PUTATIVE ORPHAN
PROTEIN

(Shewanella
frigidimarina) 		PF13474
(SnoaL_3) 		5 SER A 108
VAL A  50
VAL A  34
GLY A  32
VAL A 144
 None
 1.14A 6bqgA-3bb9A:
undetectable		 6bqgA-3bb9A:
18.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e74 ALLANTOINASE

(Escherichia
coli) 		PF01979
(Amidohydro_1) 		5 VAL A 431
GLY A 429
ALA A 386
PHE A 390
GLU A 436
 None
 1.08A 6bqgA-3e74A:
undetectable		 6bqgA-3e74A:
10.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3efe THIJ/PFPI FAMILY
PROTEIN

(Bacillus
anthracis) 		PF01965
(DJ-1_PfpI) 		5 GLY A  80
ALA A 112
PHE A 170
GLU A  25
VAL A 174
 None
 1.19A 6bqgA-3efeA:
undetectable		 6bqgA-3efeA:
20.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 ALPHA
CHAIN

(Escherichia
coli) 		PF00384
(Molybdopterin)
PF01568
(Molydop_binding)
PF14710
(Nitr_red_alph_N) 		5 ASP A 263
SER A 240
VAL A 578
ALA A 575
ASN A 798
 None
None
MGD  A1246 (-3.9A)
None
None
 1.19A 6bqgA-3egwA:
undetectable		 6bqgA-3egwA:
6.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqn GLUCAN
1,3-BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF12708
(Pectate_lyase_3) 		5 SER A 609
VAL A 668
VAL A 676
GLY A 628
PHE A 681
 None
 1.20A 6bqgA-3eqnA:
undetectable		 6bqgA-3eqnA:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3euk CHROMOSOME PARTITION
PROTEIN MUKE

([Haemophilus]
ducreyi) 		PF04288
(MukE) 		5 VAL L  97
VAL L 154
GLY L 156
PHE L 178
GLU L 122
 None
 1.20A 6bqgA-3eukL:
undetectable		 6bqgA-3eukL:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fqd 5'-3'
EXORIBONUCLEASE 2

(Schizosaccharomyces
pombe) 		PF03159
(XRN_N) 		5 VAL A 327
VAL A 624
GLY A 620
ASN A 335
VAL A 333
 None
 1.18A 6bqgA-3fqdA:
undetectable		 6bqgA-3fqdA:
6.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdf PROBABLE
NADP-DEPENDENT
MANNITOL
DEHYDROGENASE

(Cladosporium
herbarum) 		PF13561
(adh_short_C2) 		5 GLY A  27
ALA A  28
SER A  87
GLU A  89
VAL A  95
 None
 1.17A 6bqgA-3gdfA:
undetectable		 6bqgA-3gdfA:
14.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ik2 ENDOGLUCANASE A

(Clostridium
acetobutylicum) 		PF12891
(Glyco_hydro_44) 		5 ASP A 275
GLY A  22
ALA A  34
ASN A  24
ASN A  40
 None
 1.19A 6bqgA-3ik2A:
undetectable		 6bqgA-3ik2A:
9.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nbh RECQ-MEDIATED GENOME
INSTABILITY PROTEIN
2

(Homo sapiens) 		PF16100
(RMI2) 		6 VAL B 139
VAL B  58
GLY B 106
ALA B 119
PHE B  81
GLU B  28
 None
 1.32A 6bqgA-3nbhB:
undetectable		 6bqgA-3nbhB:
18.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oks 4-AMINOBUTYRATE
TRANSAMINASE

(Mycolicibacterium
smegmatis) 		PF00202
(Aminotran_3) 		5 VAL A 265
GLY A 268
ALA A 277
GLU A 132
VAL A 228
 LLP  A 292 ( 4.2A)
None
None
None
None
 1.13A 6bqgA-3oksA:
undetectable		 6bqgA-3oksA:
12.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oqn CATABOLITE CONTROL
PROTEIN A

(Bacillus
subtilis) 		PF00356
(LacI)
PF13377
(Peripla_BP_3) 		5 VAL A  52
GLY A  55
ALA A  57
ASN A  50
ASN A   3
 None
 1.17A 6bqgA-3oqnA:
undetectable		 6bqgA-3oqnA:
12.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r4c HYDROLASE, HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Bacteroides
thetaiotaomicron) 		PF08282
(Hydrolase_3) 		5 VAL A   9
VAL A 243
GLY A 247
GLU A  52
VAL A  56
 SO4  A 260 (-3.7A)
None
None
None
None
 1.08A 6bqgA-3r4cA:
undetectable		 6bqgA-3r4cA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rre PUTATIVE
UNCHARACTERIZED
PROTEIN

(Thermotoga
maritima) 		PF01256
(Carb_kinase)
PF03853
(YjeF_N) 		5 VAL A  58
GLY A  56
ALA A 115
PHE A 172
ASN A 195
 None
None
None
GOL  A 496 ( 4.7A)
None
 1.16A 6bqgA-3rreA:
undetectable		 6bqgA-3rreA:
11.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tcl CH04 HEAVY CHAIN FAB

(Homo sapiens) 		no annotation 5 VAL H 211
GLY H 157
ALA H 158
SER H 180
VAL H 184
 None
 1.01A 6bqgA-3tclH:
undetectable		 6bqgA-3tclH:
13.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v10 RHUSIOPATHIAE
SURFACE PROTEIN B

(Erysipelothrix
rhusiopathiae) 		PF05737
(Collagen_bind) 		5 VAL A  72
GLY A 344
ALA A 106
PHE A 130
GLU A  36
 None
 0.97A 6bqgA-3v10A:
undetectable		 6bqgA-3v10A:
14.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zrp SERINE-PYRUVATE
AMINOTRANSFERASE
(AGXT)

(Sulfolobus
solfataricus) 		PF00266
(Aminotran_5) 		6 SER A 203
VAL A 173
GLY A  49
ALA A  50
SER A 167
VAL A 161
 None
 1.48A 6bqgA-3zrpA:
undetectable		 6bqgA-3zrpA:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4crm TRANSLATION
INITIATION FACTOR
RLI1

(Saccharomyces
cerevisiae) 		PF00005
(ABC_tran)
PF00037
(Fer4)
PF04068
(RLI) 		5 SER P 249
VAL P 524
GLY P 224
ASN P 387
VAL P 254
 None
None
None
ADP  P1612 (-3.6A)
None
 1.10A 6bqgA-4crmP:
undetectable		 6bqgA-4crmP:
9.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ecm GLUCOSE-1-PHOSPHATE
THYMIDYLYLTRANSFERAS
E

(Bacillus
anthracis) 		PF00483
(NTP_transferase) 		5 VAL A  79
GLY A 107
ALA A  37
GLU A  56
VAL A  62
 None
DAU  A 301 ( 4.0A)
None
None
None
 1.18A 6bqgA-4ecmA:
undetectable		 6bqgA-4ecmA:
17.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ee8 PRENYLTRANSFERASE

(Streptomyces
cinnamonensis) 		PF11468
(PTase_Orf2) 		5 GLY A 192
ALA A 195
PHE A 233
SER A 216
VAL A 221
 None
 0.99A 6bqgA-4ee8A:
undetectable		 6bqgA-4ee8A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ee8 PRENYLTRANSFERASE

(Streptomyces
cinnamonensis) 		PF11468
(PTase_Orf2) 		5 VAL A 187
GLY A 192
ALA A 195
PHE A 233
VAL A 221
 None
 1.16A 6bqgA-4ee8A:
undetectable		 6bqgA-4ee8A:
15.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fgs PROBABLE
DEHYDROGENASE
PROTEIN

(Rhizobium etli) 		PF13561
(adh_short_C2) 		5 GLY A  18
ALA A  22
PHE A  86
ASN A  88
VAL A 134
 None
 1.17A 6bqgA-4fgsA:
undetectable		 6bqgA-4fgsA:
15.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fn5 ELONGATION FACTOR G
1

(Pseudomonas
aeruginosa) 		PF00009
(GTP_EFTU)
PF00679
(EFG_C)
PF03144
(GTP_EFTU_D2)
PF03764
(EFG_IV)
PF14492
(EFG_II) 		5 VAL A 262
ALA A 109
PHE A 113
GLU A 156
VAL A 119
 None
 1.17A 6bqgA-4fn5A:
undetectable		 6bqgA-4fn5A:
8.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hcj THIJ/PFPI DOMAIN
PROTEIN

(Brachyspira
murdochii) 		PF01965
(DJ-1_PfpI) 		5 VAL A  73
GLY A 107
PHE A 162
GLU A  29
VAL A 166
 None
 1.10A 6bqgA-4hcjA:
undetectable		 6bqgA-4hcjA:
19.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hnl MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME

(Enterococcus
gallinarum) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ASP A   8
GLY A  34
ALA A  96
PHE A  12
GLU A 372
 None
 1.16A 6bqgA-4hnlA:
undetectable		 6bqgA-4hnlA:
10.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hx6 OXIDOREDUCTASE

(Streptomyces
globisporus) 		PF01613
(Flavin_Reduct) 		5 SER A 118
VAL A  83
VAL A  59
GLY A 148
ALA A 133
 None
 1.11A 6bqgA-4hx6A:
undetectable		 6bqgA-4hx6A:
19.05
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		7 ASP A 135
SER A 139
GLY A 221
ALA A 225
PHE A 340
ASN A 344
VAL A 366
 ERM  A2001 (-3.2A)
ERM  A2001 (-3.6A)
ERM  A2001 ( 4.3A)
ERM  A2001 (-3.4A)
ERM  A2001 (-4.3A)
ERM  A2001 (-4.3A)
ERM  A2001 ( 4.2A)
 0.44A 6bqgA-4ib4A:
36.4		 6bqgA-4ib4A:
62.32
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		7 ASP A 135
SER A 139
VAL A 208
GLY A 221
ALA A 225
PHE A 340
VAL A 366
 ERM  A2001 (-3.2A)
ERM  A2001 (-3.6A)
ERM  A2001 (-4.0A)
ERM  A2001 ( 4.3A)
ERM  A2001 (-3.4A)
ERM  A2001 (-4.3A)
ERM  A2001 ( 4.2A)
 0.48A 6bqgA-4ib4A:
36.4		 6bqgA-4ib4A:
62.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4keq 4-PYRIDOXOLACTONASE

(Mesorhizobium
japonicum) 		PF00753
(Lactamase_B) 		5 GLY A 103
PHE A  97
ASN A  94
GLU A 165
VAL A 120
 None
None
None
None
GOL  A 305 (-3.8A)
 1.08A 6bqgA-4keqA:
undetectable		 6bqgA-4keqA:
14.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m62 T117

(synthetic
construct) 		PF00359
(PTS_EIIA_2) 		5 VAL S  88
VAL S  71
GLY S  63
ALA S 100
VAL S 126
 None
 0.98A 6bqgA-4m62S:
undetectable		 6bqgA-4m62S:
21.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mch URIDINE
PHOSPHORYLASE

(Aliivibrio
fischeri) 		PF01048
(PNP_UDP_1) 		5 ASP A 179
SER A 154
VAL A 105
GLY A 150
PHE A 186
 None
 1.14A 6bqgA-4mchA:
undetectable		 6bqgA-4mchA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mch URIDINE
PHOSPHORYLASE

(Aliivibrio
fischeri) 		PF01048
(PNP_UDP_1) 		5 ASP A 179
VAL A  88
VAL A 105
GLY A 150
PHE A 186
 None
 1.18A 6bqgA-4mchA:
undetectable		 6bqgA-4mchA:
13.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ni5 OXIDOREDUCTASE,
SHORT-CHAIN
DEHYDROGENASE/REDUCT
ASE FAMILY PROTEIN

(Brucella suis) 		PF13561
(adh_short_C2) 		5 GLY A  16
ALA A  20
PHE A  86
ASN A  88
VAL A 136
 None
 1.14A 6bqgA-4ni5A:
undetectable		 6bqgA-4ni5A:
14.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4om9 SERINE PROTEASE PET

(Escherichia
coli) 		PF02395
(Peptidase_S6) 		5 VAL A 477
GLY A 475
ALA A 445
GLU A 460
ASN A 437
 None
 1.18A 6bqgA-4om9A:
undetectable		 6bqgA-4om9A:
6.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p2i MKIAA0254 PROTEIN

(Mus musculus) 		PF00787
(PX) 		5 VAL A 611
GLY A 613
GLU A 650
ASN A 653
VAL A 657
 None
 1.13A 6bqgA-4p2iA:
2.3		 6bqgA-4p2iA:
15.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p3i P DOMAIN OF VP1

(Norwalk virus) 		PF00915
(Calici_coat)
PF08435
(Calici_coat_C) 		5 VAL A 525
VAL A 427
PHE A 510
GLU A 482
ASN A 479
 None
 1.13A 6bqgA-4p3iA:
undetectable		 6bqgA-4p3iA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pwy CALMODULIN-LYSINE
N-METHYLTRANSFERASE

(Homo sapiens) 		PF10294
(Methyltransf_16) 		5 VAL A 125
VAL A  89
GLY A  76
GLU A 132
ASN A  69
 None
None
UNX  A 418 ( 3.5A)
UNX  A 420 ( 3.3A)
UNX  A 421 ( 3.9A)
 1.14A 6bqgA-4pwyA:
undetectable		 6bqgA-4pwyA:
15.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qme AMINOPEPTIDASE N

(Neisseria
meningitidis) 		PF01433
(Peptidase_M1)
PF11940
(DUF3458)
PF17432
(DUF3458_C) 		5 GLY A 292
ALA A 229
PHE A 246
ASN A 265
ASN A 154
 None
 1.16A 6bqgA-4qmeA:
2.0		 6bqgA-4qmeA:
6.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qpy COMPLEMENT C1Q-LIKE
PROTEIN 2

(Mus musculus) 		PF00386
(C1q) 		5 VAL A  24
GLY A  21
ALA A 118
ASN A  33
VAL A  13
 None
 1.13A 6bqgA-4qpyA:
undetectable		 6bqgA-4qpyA:
21.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r8e 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 2

(Yersinia pestis) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 VAL A 167
GLY A 171
ALA A 174
PHE A 409
VAL A 354
 None
 1.13A 6bqgA-4r8eA:
undetectable		 6bqgA-4r8eA:
12.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rf3 NADPH DEPENDENT
R-SPECIFIC ALCOHOL
DEHYDROGENASE

(Lactobacillus
kefiri) 		PF13561
(adh_short_C2) 		5 GLY A 117
ALA A  64
ASN A 140
SER A 167
GLU A 242
 None
 1.20A 6bqgA-4rf3A:
undetectable		 6bqgA-4rf3A:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rgk UNCHARACTERIZED
PROTEIN

(Yersinia pestis) 		PF07350
(DUF1479) 		5 VAL A  89
GLY A 329
ALA A 260
PHE A 333
ASN A 160
 None
 1.21A 6bqgA-4rgkA:
undetectable		 6bqgA-4rgkA:
11.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxt SUGAR ABC
TRANSPORTER

(Agrobacterium
tumefaciens) 		PF13407
(Peripla_BP_4) 		5 SER A  46
VAL A 275
GLY A 237
ALA A 207
ASN A 139
 None
 1.11A 6bqgA-4rxtA:
undetectable		 6bqgA-4rxtA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uup MALATE DEHYDROGENASE

(synthetic
construct) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 ASP A  81
VAL A  68
GLY A  66
ALA A  65
GLU A  74
 None
 1.20A 6bqgA-4uupA:
undetectable		 6bqgA-4uupA:
14.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xaa PUTATIVE OXYGENASE

(Streptomyces
viridochromogenes) 		PF05721
(PhyH) 		5 VAL A 131
GLY A 158
PHE A  15
GLU A 213
VAL A 100
 None
 1.13A 6bqgA-4xaaA:
undetectable		 6bqgA-4xaaA:
17.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yry DIHYDROPYRIMIDINE
DEHYDROGENASE
SUBUNIT A

(Thermotoga
maritima) 		PF07992
(Pyr_redox_2)
PF14691
(Fer4_20) 		5 VAL B 213
VAL B 229
ALA B 451
GLU B 402
ASN B 396
 FAD  B 503 (-3.9A)
None
None
None
None
 1.10A 6bqgA-4yryB:
1.4		 6bqgA-4yryB:
8.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4zd6 HALOHYDRIN EPOXIDASE
B

(Corynebacterium
sp.) 		PF13561
(adh_short_C2) 		5 SER A 118
VAL A 188
GLY A 223
PHE A 170
GLU A 179
 None
None
None
CL  A 301 (-4.8A)
None
 1.09A 6bqgA-4zd6A:
undetectable		 6bqgA-4zd6A:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dte MONOSACCHARIDE-TRANS
PORTING ATPASE

(Actinobacillus
succinogenes) 		PF13407
(Peripla_BP_4) 		5 VAL A 261
VAL A 234
GLY A 232
ALA A 205
ASN A 150
 None
 1.12A 6bqgA-5dteA:
undetectable		 6bqgA-5dteA:
16.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ep8 PYRIMIDINE-NUCLEOSID
E PHOSPHORYLASE

(Bacillus
subtilis) 		PF00591
(Glycos_transf_3)
PF02885
(Glycos_trans_3N)
PF07831
(PYNP_C) 		5 SER A 110
GLY A 192
ALA A 191
PHE A 139
ASN A 315
 SER  A 110 (-0.0A)
GLY  A 192 ( 0.0A)
ALA  A 191 ( 0.0A)
PHE  A 139 ( 1.3A)
ASN  A 315 ( 0.6A)
 1.19A 6bqgA-5ep8A:
undetectable		 6bqgA-5ep8A:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5eqi SOLUTE CARRIER
FAMILY 2,
FACILITATED GLUCOSE
TRANSPORTER MEMBER 1

(Homo sapiens) 		PF00083
(Sugar_tr) 		5 VAL A 165
GLY A 167
ALA A 171
ASN A 317
VAL A 290
 None
 1.12A 6bqgA-5eqiA:
2.1		 6bqgA-5eqiA:
12.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lu4 PYRUVATE, PHOSPHATE
DIKINASE,
CHLOROPLASTIC

(Flaveria
trinervia) 		PF00391
(PEP-utilizers)
PF01326
(PPDK_N)
PF02896
(PEP-utilizers_C) 		5 GLY A 557
ALA A 555
SER A 767
GLU A 748
ASN A 771
 None
None
None
MG  A 904 ( 2.7A)
PYR  A 903 (-3.8A)
 1.05A 6bqgA-5lu4A:
undetectable		 6bqgA-5lu4A:
7.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m8t 5,6-DIHYDROXYINDOLE-
2-CARBOXYLIC ACID
OXIDASE

(Homo sapiens) 		PF00264
(Tyrosinase) 		5 ASP A 212
SER A 214
ASN A 378
SER A 374
VAL A 391
 None
None
0TR  A 513 ( 4.4A)
None
0TR  A 513 (-3.8A)
 1.12A 6bqgA-5m8tA:
undetectable		 6bqgA-5m8tA:
10.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdh MALATE DEHYDROGENASE

(Sus scrofa) 		PF00056
(Ldh_1_N)
PF02866
(Ldh_1_C) 		5 SER A 152
VAL A  86
GLY A 129
ALA A 132
VAL A 253
 None
NAD  A 334 (-4.5A)
NAD  A 334 (-3.6A)
NAD  A 334 ( 4.4A)
None
 0.91A 6bqgA-5mdhA:
undetectable		 6bqgA-5mdhA:
14.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oy0 PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A1

(Synechocystis
sp. PCC 6803) 		no annotation 5 ASP 1 589
SER 1 586
VAL 1 402
GLY 1 405
ALA 1 409
 None
None
CLA  1 830 ( 4.7A)
BCR  1 848 ( 3.9A)
None
 1.12A 6bqgA-5oy01:
1.7		 6bqgA-5oy01:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xtc NADH DEHYDROGENASE
[UBIQUINONE] 1 ALPHA
SUBCOMPLEX SUBUNIT
11
NADH-UBIQUINONE
OXIDOREDUCTASE CHAIN
2

(Homo sapiens) 		no annotation 5 SER i 146
VAL V 141
ASN i 273
GLU i 268
VAL i 193
 None
 1.17A 6bqgA-5xtci:
2.4		 6bqgA-5xtci:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z7r SHORT-CHAIN-ENOYL-CO
A HYDRATASE

(Clostridium
acetobutylicum) 		no annotation 5 VAL A   6
VAL A  63
GLY A  65
PHE A  90
VAL A  89
 None
 1.03A 6bqgA-5z7rA:
undetectable		 6bqgA-5z7rA:
24.10
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 9 ASP A 134
SER A 138
VAL A 208
VAL A 215
ALA A 222
PHE A 327
ASN A 331
ASN A 351
VAL A 354
 E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
None
E2J  A1201 (-4.6A)
E2J  A1201 ( 3.8A)
E2J  A1201 (-4.6A)
None
E2J  A1201 (-3.8A)
E2J  A1201 (-4.6A)
 0.97A 6bqgA-6bqhA:
36.0		 6bqgA-6bqhA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 9 ASP A 134
SER A 138
VAL A 208
VAL A 215
ALA A 222
PHE A 327
ASN A 331
GLU A 347
VAL A 354
 E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
None
E2J  A1201 (-4.6A)
E2J  A1201 ( 3.8A)
E2J  A1201 (-4.6A)
None
None
E2J  A1201 (-4.6A)
 1.12A 6bqgA-6bqhA:
36.0		 6bqgA-6bqhA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 7 ASP A 134
SER A 138
VAL A 208
VAL A 215
GLY A 218
ALA A 222
ASN A 351
 E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
None
E2J  A1201 (-4.6A)
E2J  A1201 (-3.1A)
E2J  A1201 ( 3.8A)
E2J  A1201 (-3.8A)
 0.83A 6bqgA-6bqhA:
36.0		 6bqgA-6bqhA:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6bqh 5-HYDROXYTRYPTAMINE
RECEPTOR 2C,SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		no annotation 7 ASP A 134
SER A 138
VAL A 208
VAL A 215
GLY A 218
ALA A 222
GLU A 347
 E2J  A1201 (-3.0A)
E2J  A1201 (-3.2A)
None
E2J  A1201 (-4.6A)
E2J  A1201 (-3.1A)
E2J  A1201 ( 3.8A)
None
 1.03A 6bqgA-6bqhA:
36.0		 6bqgA-6bqhA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eu6 AMMONIUM TRANSPORTER

(Candidatus
Kuenenia
stuttgartiensis) 		no annotation 5 ASP A  50
VAL A 102
VAL A 170
GLY A 174
ALA A 178
 NH4  A 505 (-2.8A)
None
None
None
None
 1.04A 6bqgA-6eu6A:
2.0		 6bqgA-6eu6A:
24.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bdg HEXOKINASE

(Schistosoma
mansoni) 		PF00349
(Hexokinase_1)
PF03727
(Hexokinase_2) 		4 VAL A 230
THR A 234
LEU A 443
VAL A 408
 None
 0.93A 6bqgA-1bdgA:
undetectable		 6bqgA-1bdgA:
9.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dj2 ADENYLOSUCCINATE
SYNTHETASE

(Arabidopsis
thaliana) 		PF00709
(Adenylsucc_synt) 		4 VAL A  86
THR A  84
LEU A 270
VAL A 276
 None
 0.94A 6bqgA-1dj2A:
0.0		 6bqgA-1dj2A:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dlm CATECHOL
1,2-DIOXYGENASE

(Acinetobacter
sp. ADP1) 		PF00775
(Dioxygenase_C)
PF04444
(Dioxygenase_N) 		4 VAL A 153
THR A 184
VAL A 263
LEU A 134
 None
 0.87A 6bqgA-1dlmA:
0.8		 6bqgA-1dlmA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f8w NADH PEROXIDASE

(Enterococcus
faecalis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 VAL A  91
THR A  77
VAL A 276
LEU A 251
 None
 0.99A 6bqgA-1f8wA:
undetectable		 6bqgA-1f8wA:
10.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gnw GLUTATHIONE
S-TRANSFERASE

(Arabidopsis
thaliana) 		PF00043
(GST_C)
PF02798
(GST_N) 		4 VAL A 198
THR A 202
LEU A 147
VAL A 113
 None
 1.01A 6bqgA-1gnwA:
2.8		 6bqgA-1gnwA:
19.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h2b ALCOHOL
DEHYDROGENASE

(Aeropyrum
pernix) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 VAL A 309
LEU A 198
VAL A 329
LEU A 205
 NAJ  A1361 (-3.7A)
NAJ  A1361 (-3.7A)
None
None
 0.84A 6bqgA-1h2bA:
undetectable		 6bqgA-1h2bA:
12.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1i7q ANTHRANILATE
SYNTHASE

(Serratia
marcescens) 		PF00425
(Chorismate_bind)
PF04715
(Anth_synt_I_N) 		4 VAL A 144
LEU A  80
VAL A  70
LEU A  73
 None
 0.98A 6bqgA-1i7qA:
0.0		 6bqgA-1i7qA:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jwa MOLYBDOPTERIN
BIOSYNTHESIS MOEB
PROTEIN

(Escherichia
coli) 		PF00899
(ThiF) 		4 VAL B 106
THR B 104
LEU B 110
LEU B 138
 None
 1.02A 6bqgA-1jwaB:
undetectable		 6bqgA-1jwaB:
12.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jx2 MYOSIN-2 HEAVY
CHAIN,DYNAMIN-A

(Dictyostelium
discoideum) 		PF00063
(Myosin_head)
PF02736
(Myosin_N) 		4 VAL A 989
THR A 991
LEU A1067
VAL A 916
 None
 1.02A 6bqgA-1jx2A:
2.0		 6bqgA-1jx2A:
5.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lqa TAS PROTEIN

(Escherichia
coli) 		PF00248
(Aldo_ket_red) 		4 VAL A  49
THR A  20
LEU A 126
LEU A  11
 None
 1.03A 6bqgA-1lqaA:
0.0		 6bqgA-1lqaA:
10.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lrk UDP-GLUCOSE
4-EPIMERASE

(Escherichia
coli) 		PF16363
(GDP_Man_Dehyd) 		4 VAL A  55
THR A  53
LEU A  64
LEU A 107
 None
 0.99A 6bqgA-1lrkA:
undetectable		 6bqgA-1lrkA:
13.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o9g RRNA
METHYLTRANSFERASE

(Streptomyces
viridochromogenes) 		PF11599
(AviRa) 		4 VAL A 238
LEU A 197
VAL A 154
LEU A 204
 None
 0.95A 6bqgA-1o9gA:
undetectable		 6bqgA-1o9gA:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qor QUINONE
OXIDOREDUCTASE

(Escherichia
coli) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		4 VAL A 128
LEU A 283
VAL A  86
LEU A 276
 None
 0.91A 6bqgA-1qorA:
undetectable		 6bqgA-1qorA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qpa LIGNIN PEROXIDASE

(Phanerochaete
chrysosporium) 		PF00141
(peroxidase)
PF11895
(Peroxidase_ext) 		4 VAL A 225
LEU A 240
VAL A 154
LEU A 173
 None
None
None
HEM  A 350 (-4.9A)
 1.03A 6bqgA-1qpaA:
undetectable		 6bqgA-1qpaA:
12.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1su7 CARBON MONOXIDE
DEHYDROGENASE 2

(Carboxydothermus
hydrogenoformans) 		PF03063
(Prismane) 		4 THR A 401
LEU A 495
VAL A 471
LEU A 504
 None
 1.01A 6bqgA-1su7A:
2.0		 6bqgA-1su7A:
8.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t34 ATRIAL NATRIURETIC
PEPTIDE RECEPTOR A

(Rattus
norvegicus) 		PF01094
(ANF_receptor) 		4 VAL A  93
THR A  97
VAL A  23
LEU A  50
 None
 1.00A 6bqgA-1t34A:
undetectable		 6bqgA-1t34A:
10.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t4k IMMUNOGLOBULIN IGG1,
HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		4 VAL B 109
THR B 107
LEU B  83
LEU B  63
 None
 1.02A 6bqgA-1t4kB:
undetectable		 6bqgA-1t4kB:
14.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w85 PYRUVATE
DEHYDROGENASE E1
COMPONENT, ALPHA
SUBUNIT

(Geobacillus
stearothermophilus) 		PF00676
(E1_dh) 		4 VAL A 241
THR A 263
LEU A  49
LEU A 296
 None
 1.01A 6bqgA-1w85A:
undetectable		 6bqgA-1w85A:
12.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wyt GLYCINE
DEHYDROGENASE
(DECARBOXYLATING)
SUBUNIT 1

(Thermus
thermophilus) 		PF02347
(GDC-P) 		4 VAL A 193
LEU A 181
VAL A 159
LEU A 178
 None
 1.02A 6bqgA-1wytA:
undetectable		 6bqgA-1wytA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xn4 RIBONUCLEASE MAR1

(Leishmania
major) 		PF00857
(Isochorismatase) 		4 VAL A 117
LEU A 134
VAL A  37
LEU A  20
 None
 0.99A 6bqgA-1xn4A:
undetectable		 6bqgA-1xn4A:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z6t APOPTOTIC PROTEASE
ACTIVATING FACTOR 1

(Homo sapiens) 		PF00619
(CARD)
PF00931
(NB-ARC) 		4 VAL A 442
THR A 446
VAL A 399
LEU A 415
 None
 0.97A 6bqgA-1z6tA:
3.4		 6bqgA-1z6tA:
10.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2bku IMPORTIN BETA-1
SUBUNIT

(Saccharomyces
cerevisiae) 		PF03810
(IBN_N)
PF13513
(HEAT_EZ) 		4 VAL B 535
THR B 532
VAL B 456
LEU B 503
 None
 0.98A 6bqgA-2bkuB:
2.6		 6bqgA-2bkuB:
7.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gsn PHOSPHODIESTERASE-NU
CLEOTIDE
PYROPHOSPHATASE

(Xanthomonas
citri) 		PF01663
(Phosphodiest) 		4 VAL A 288
THR A 284
LEU A 320
LEU A 306
 None
 0.99A 6bqgA-2gsnA:
undetectable		 6bqgA-2gsnA:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hgs PROTEIN (GLUTATHIONE
SYNTHETASE)

(Homo sapiens) 		PF03199
(GSH_synthase)
PF03917
(GSH_synth_ATP) 		4 VAL A 307
THR A 304
LEU A 320
LEU A 331
 None
 0.86A 6bqgA-2hgsA:
undetectable		 6bqgA-2hgsA:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hne L-FUCONATE
DEHYDRATASE

(Xanthomonas
campestris) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 THR A 177
LEU A 144
VAL A 331
LEU A 338
 None
 0.92A 6bqgA-2hneA:
undetectable		 6bqgA-2hneA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2jgd 2-OXOGLUTARATE
DEHYDROGENASE E1
COMPONENT

(Escherichia
coli) 		PF00676
(E1_dh)
PF02779
(Transket_pyr)
PF16870
(OxoGdeHyase_C) 		4 VAL A 254
THR A 251
LEU A 271
VAL A 520
 None
 0.95A 6bqgA-2jgdA:
undetectable		 6bqgA-2jgdA:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nq3 ITCHY HOMOLOG E3
UBIQUITIN PROTEIN
LIGASE

(Homo sapiens) 		PF00168
(C2) 		4 VAL A 116
LEU A 100
VAL A  45
LEU A 135
 None
CL  A 156 ( 4.8A)
None
None
 0.97A 6bqgA-2nq3A:
undetectable		 6bqgA-2nq3A:
14.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nty EMB|CAB41934.1

(Arabidopsis
thaliana) 		PF03759
(PRONE) 		4 VAL A  79
LEU A 110
VAL A 200
LEU A 117
 None
 1.03A 6bqgA-2ntyA:
undetectable		 6bqgA-2ntyA:
11.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oqh PUTATIVE ISOMERASE

(Streptomyces
coelicolor) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		4 VAL A 249
LEU A 283
VAL A 318
LEU A 296
 None
 0.98A 6bqgA-2oqhA:
undetectable		 6bqgA-2oqhA:
11.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pl3 PROBABLE
ATP-DEPENDENT RNA
HELICASE DDX10

(Homo sapiens) 		PF00270
(DEAD) 		4 VAL A 239
THR A 235
LEU A 219
LEU A 268
 None
 0.90A 6bqgA-2pl3A:
undetectable		 6bqgA-2pl3A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pma UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		PF05618
(Zn_protease) 		4 VAL A  75
THR A  77
LEU A 118
LEU A 145
 None
ACT  A 203 ( 3.8A)
None
None
 0.75A 6bqgA-2pmaA:
undetectable		 6bqgA-2pmaA:
19.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qm3 PREDICTED
METHYLTRANSFERASE

(Pyrococcus
furiosus) 		PF01861
(DUF43) 		4 VAL A   8
THR A  12
LEU A  55
VAL A  67
 None
 0.74A 6bqgA-2qm3A:
undetectable		 6bqgA-2qm3A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2uyo HYPOTHETICAL PROTEIN
ML2640

(Mycobacterium
leprae) 		PF04072
(LCM) 		4 VAL A 107
THR A 181
LEU A 162
LEU A 189
 None
 0.98A 6bqgA-2uyoA:
undetectable		 6bqgA-2uyoA:
10.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vqa SLL1358 PROTEIN

(Synechocystis
sp. PCC 6803) 		PF00190
(Cupin_1) 		4 VAL A 133
THR A 117
VAL A 344
LEU A 271
 ACT  A1396 (-3.9A)
None
None
None
 0.97A 6bqgA-2vqaA:
undetectable		 6bqgA-2vqaA:
12.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wst PUTATIVE FIBER
PROTEIN

(Porcine
mastadenovirus
B) 		PF00541
(Adeno_knob) 		4 VAL A 205
THR A 203
VAL A 117
LEU A 214
 None
 0.91A 6bqgA-2wstA:
undetectable		 6bqgA-2wstA:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xik SERINE/THREONINE
PROTEIN KINASE 25

(Homo sapiens) 		PF00069
(Pkinase) 		4 VAL A 247
LEU A 121
VAL A 146
LEU A 128
 None
 0.83A 6bqgA-2xikA:
2.4		 6bqgA-2xikA:
15.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ziu CROSSOVER JUNCTION
ENDONUCLEASE EME1
MUS81 PROTEIN

(Danio rerio;
Homo sapiens) 		PF02732
(ERCC4) 		4 VAL B 500
LEU B 510
VAL A 561
LEU A 604
 None
 1.02A 6bqgA-2ziuB:
undetectable		 6bqgA-2ziuB:
11.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ahr ERO1-LIKE PROTEIN
ALPHA

(Homo sapiens) 		PF04137
(ERO1) 		4 VAL A 152
THR A 156
LEU A 144
LEU A 181
 None
 0.98A 6bqgA-3ahrA:
2.4		 6bqgA-3ahrA:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bfn KINESIN-LIKE PROTEIN
KIF22

(Homo sapiens) 		PF00225
(Kinesin) 		4 VAL A 108
LEU A 270
VAL A 172
LEU A 116
 None
 0.86A 6bqgA-3bfnA:
undetectable		 6bqgA-3bfnA:
11.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fah ALDEHYDE
OXIDOREDUCTASE

(Desulfovibrio
gigas) 		PF00111
(Fer2)
PF01315
(Ald_Xan_dh_C)
PF01799
(Fer2_2)
PF02738
(Ald_Xan_dh_C2) 		4 VAL A  17
LEU A  31
VAL A  36
LEU A 201
 None
 1.02A 6bqgA-3fahA:
undetectable		 6bqgA-3fahA:
6.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g65 CHECKPOINT PROTEIN
HUS1

(Homo sapiens) 		PF04005
(Hus1) 		4 VAL C 169
THR C 165
LEU C 180
VAL C 261
 None
 1.02A 6bqgA-3g65C:
undetectable		 6bqgA-3g65C:
13.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hc1 UNCHARACTERIZED HDOD
DOMAIN PROTEIN

(Geobacter
sulfurreducens) 		PF08668
(HDOD) 		4 VAL A  32
LEU A 150
VAL A 156
LEU A 199
 None
 0.95A 6bqgA-3hc1A:
2.3		 6bqgA-3hc1A:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ide CAPSID PROTEIN VP2

(Infectious
pancreatic
necrosis virus) 		PF01766
(Birna_VP2) 		4 VAL A 275
LEU A 222
VAL A 216
LEU A 225
 None
 0.94A 6bqgA-3ideA:
undetectable		 6bqgA-3ideA:
11.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3k96 GLYCEROL-3-PHOSPHATE
DEHYDROGENASE
[NAD(P)+]

(Coxiella
burnetii) 		PF01210
(NAD_Gly3P_dh_N)
PF07479
(NAD_Gly3P_dh_C) 		4 VAL A  31
THR A  62
VAL A 144
LEU A  54
 None
 0.91A 6bqgA-3k96A:
1.1		 6bqgA-3k96A:
12.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lad DIHYDROLIPOAMIDE
DEHYDROGENASE

(Azotobacter
vinelandii) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 VAL A   6
THR A  29
VAL A 319
LEU A 285
 None
None
None
FAD  A 480 (-4.8A)
 1.01A 6bqgA-3ladA:
2.6		 6bqgA-3ladA:
10.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lbf PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Escherichia
coli) 		PF01135
(PCMT) 		4 VAL A 125
THR A 127
VAL A  64
LEU A  71
 None
 0.83A 6bqgA-3lbfA:
undetectable		 6bqgA-3lbfA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mc1 PREDICTED
PHOSPHATASE, HAD
FAMILY

(Clostridium
acetobutylicum) 		PF13419
(HAD_2) 		4 VAL A 105
THR A 107
LEU A  93
VAL A 205
 None
 1.01A 6bqgA-3mc1A:
undetectable		 6bqgA-3mc1A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n05 NH(3)-DEPENDENT
NAD(+) SYNTHETASE

(Streptomyces
avermitilis) 		PF00795
(CN_hydrolase)
PF02540
(NAD_synthase) 		4 THR A  28
LEU A 183
VAL A 149
LEU A   3
 None
 0.93A 6bqgA-3n05A:
undetectable		 6bqgA-3n05A:
11.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n28 PHOSPHOSERINE
PHOSPHATASE

(Vibrio cholerae) 		PF00702
(Hydrolase) 		4 VAL A 267
LEU A 186
VAL A  68
LEU A 104
 None
 0.97A 6bqgA-3n28A:
undetectable		 6bqgA-3n28A:
13.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nks PROTOPORPHYRINOGEN
OXIDASE

(Homo sapiens) 		PF01593
(Amino_oxidase) 		4 VAL A   6
THR A   4
LEU A 260
LEU A 442
 None
 0.99A 6bqgA-3nksA:
undetectable		 6bqgA-3nksA:
9.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oaa ATP SYNTHASE SUBUNIT
BETA

(Escherichia
coli) 		PF00006
(ATP-synt_ab)
PF02874
(ATP-synt_ab_N) 		4 VAL D 277
LEU D 221
VAL D 179
LEU D 239
 None
 0.95A 6bqgA-3oaaD:
undetectable		 6bqgA-3oaaD:
12.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pft FLAVIN REDUCTASE

(Mycolicibacterium
goodii) 		PF01613
(Flavin_Reduct) 		4 VAL A 133
THR A 131
LEU A  71
VAL A  34
 None
 0.92A 6bqgA-3pftA:
undetectable		 6bqgA-3pftA:
19.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pgv HALOACID
DEHALOGENASE-LIKE
HYDROLASE

(Klebsiella
pneumoniae) 		PF08282
(Hydrolase_3) 		4 VAL A 102
THR A 150
LEU A 133
LEU A 139
 None
 0.99A 6bqgA-3pgvA:
undetectable		 6bqgA-3pgvA:
13.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pmm PUTATIVE CYTOPLASMIC
PROTEIN

(Klebsiella
pneumoniae) 		PF07470
(Glyco_hydro_88) 		4 VAL A 173
THR A 168
VAL A 254
LEU A 243
 None
 0.93A 6bqgA-3pmmA:
undetectable		 6bqgA-3pmmA:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sfz APOPTOTIC PEPTIDASE
ACTIVATING FACTOR 1

(Mus musculus) 		PF00400
(WD40)
PF00931
(NB-ARC)
PF12894
(ANAPC4_WD40) 		4 VAL A 442
THR A 446
VAL A 399
LEU A 415
 None
GBL  A1251 (-3.6A)
None
None
 0.82A 6bqgA-3sfzA:
undetectable		 6bqgA-3sfzA:
4.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sto SERINE PROTEASE
INHIBITOR

(Schistosoma
haematobium) 		PF00079
(Serpin) 		4 VAL A 256
THR A 254
LEU A 272
LEU A  27
 None
 1.02A 6bqgA-3stoA:
undetectable		 6bqgA-3stoA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut3 PLASMINOGEN
ACTIVATOR INHIBITOR
1

(Homo sapiens) 		PF00079
(Serpin) 		4 VAL A  42
LEU A 286
VAL A  23
LEU A 293
 None
 0.95A 6bqgA-3ut3A:
undetectable		 6bqgA-3ut3A:
10.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vm7 ALPHA-AMYLASE

(Malbranchea
cinnamomea) 		PF00128
(Alpha-amylase)
PF09260
(DUF1966) 		4 THR A  87
LEU A 195
VAL A 230
LEU A 185
 None
 0.97A 6bqgA-3vm7A:
undetectable		 6bqgA-3vm7A:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vtr N-ACETYLGLUCOSAMINID
ASE

(Ostrinia
furnacalis) 		PF00728
(Glyco_hydro_20)
PF14845
(Glycohydro_20b2) 		4 VAL A 112
LEU A 182
VAL A 201
LEU A  65
 None
 0.99A 6bqgA-3vtrA:
undetectable		 6bqgA-3vtrA:
9.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wgc L-ALLO-THREONINE
ALDOLASE

(Aeromonas
jandaei) 		PF01212
(Beta_elim_lyase) 		4 VAL A 248
LEU A  48
VAL A 210
LEU A  41
 None
 0.87A 6bqgA-3wgcA:
undetectable		 6bqgA-3wgcA:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wlx LOW SPECIFICITY
L-THREONINE ALDOLASE

(Escherichia
coli) 		no annotation 4 VAL B 246
LEU B  46
VAL B 208
LEU B  39
 None
 1.02A 6bqgA-3wlxB:
undetectable		 6bqgA-3wlxB:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4aq1 SBSB PROTEIN

(Geobacillus
stearothermophilus) 		no annotation 4 VAL C 852
LEU C 890
VAL C 750
LEU C 761
 None
 1.03A 6bqgA-4aq1C:
undetectable		 6bqgA-4aq1C:
7.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b0s DEAMIDASE-DEPUPYLASE
DOP

(Acidothermus
cellulolyticus) 		PF03136
(Pup_ligase) 		5 VAL A 105
THR A 432
LEU A 258
VAL A 242
LEU A 265
 None
 1.36A 6bqgA-4b0sA:
undetectable		 6bqgA-4b0sA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b8w GDP-L-FUCOSE
SYNTHASE

(Homo sapiens) 		PF01370
(Epimerase) 		4 VAL A 168
THR A 166
LEU A 223
VAL A  26
 None
 1.00A 6bqgA-4b8wA:
undetectable		 6bqgA-4b8wA:
14.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bfr PHOSPHATIDYLINOSITOL
4,5-BISPHOSPHATE
3-KINASE CATALYTIC S
SUBUNIT BETA ISOFORM

(Mus musculus) 		PF00454
(PI3_PI4_kinase)
PF00613
(PI3Ka)
PF00792
(PI3K_C2)
PF00794
(PI3K_rbd) 		4 VAL A 439
LEU A 351
VAL A 362
LEU A 467
 None
 0.94A 6bqgA-4bfrA:
undetectable		 6bqgA-4bfrA:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d61 EUKARYOTIC PEPTIDE
CHAIN RELEASE FACTOR
GTP-BINDING SUBUNIT
ERF3A

(Homo sapiens) 		PF01201
(Ribosomal_S8e) 		4 VAL i 485
THR i 482
LEU i 433
LEU i 495
 None
 1.02A 6bqgA-4d61i:
undetectable		 6bqgA-4d61i:
11.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4evz HISF-LUCA

(synthetic
construct) 		PF00977
(His_biosynth) 		4 VAL A  65
THR A  61
LEU A  77
LEU A  93
 None
 1.03A 6bqgA-4evzA:
undetectable		 6bqgA-4evzA:
16.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ezg PUTATIVE
UNCHARACTERIZED
PROTEIN

(Listeria
monocytogenes) 		no annotation 4 THR A 185
LEU A 171
VAL A 199
LEU A 214
 None
 0.92A 6bqgA-4ezgA:
undetectable		 6bqgA-4ezgA:
15.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwg TTC1975 PEPTIDASE

(Meiothermus
taiwanensis) 		PF05362
(Lon_C)
PF13654
(AAA_32) 		4 VAL A 674
LEU A 585
VAL A 499
LEU A 502
 None
 0.98A 6bqgA-4fwgA:
undetectable		 6bqgA-4fwgA:
7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4hjh PHOSPHOMANNOMUTASE

(Brucella
melitensis) 		PF00408
(PGM_PMM_IV)
PF02878
(PGM_PMM_I)
PF02879
(PGM_PMM_II)
PF02880
(PGM_PMM_III) 		4 THR A 215
LEU A 190
VAL A 177
LEU A 204
 None
 1.03A 6bqgA-4hjhA:
undetectable		 6bqgA-4hjhA:
13.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4htf S-ADENOSYLMETHIONINE
-DEPENDENT
METHYLTRANSFERASE

(Escherichia
coli) 		PF13847
(Methyltransf_31) 		4 VAL B  69
LEU B 117
VAL B 121
LEU B 135
 None
None
SAM  B 301 ( 4.3A)
None
 0.89A 6bqgA-4htfB:
undetectable		 6bqgA-4htfB:
12.27
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4ib4 CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562

(Escherichia
coli;
Homo sapiens) 		PF00001
(7tm_1)
PF07361
(Cytochrom_B562) 		5 VAL A 136
THR A 140
LEU A 209
VAL A 348
LEU A 362
 ERM  A2001 (-3.8A)
ERM  A2001 (-3.9A)
ERM  A2001 (-3.7A)
ERM  A2001 ( 4.9A)
ERM  A2001 ( 4.1A)
 0.73A 6bqgA-4ib4A:
36.4		 6bqgA-4ib4A:
62.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4j57 THIOREDOXIN
REDUCTASE 2

(Plasmodium
falciparum) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		4 VAL A 358
LEU A 323
VAL A 169
LEU A 328
 None
FAD  A 601 (-4.9A)
None
None
 0.93A 6bqgA-4j57A:
3.2		 6bqgA-4j57A:
10.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k3w ENOYL-COA
HYDRATASE/ISOMERASE

(Marinobacter
hydrocarbonoclasticus) 		PF00378
(ECH_1) 		4 VAL A  20
THR A  22
LEU A 207
LEU A 132
 None
 0.66A 6bqgA-4k3wA:
undetectable		 6bqgA-4k3wA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l7v PROTEIN-L-ISOASPARTA
TE
O-METHYLTRANSFERASE

(Vibrio cholerae) 		PF01135
(PCMT) 		4 VAL A 125
THR A 127
VAL A  64
LEU A  71
 None
 0.85A 6bqgA-4l7vA:
undetectable		 6bqgA-4l7vA:
14.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4oe1 CHLOROPLAST
PENTATRICOPEPTIDE
REPEAT PROTEIN 10

(Zea mays) 		PF01535
(PPR)
PF12854
(PPR_1)
PF13041
(PPR_2)
PF13812
(PPR_3) 		4 VAL A 210
THR A 208
VAL A 157
LEU A 184
 U  C   2 ( 3.7A)
G  C   1 ( 3.9A)
None
None
 0.83A 6bqgA-4oe1A:
undetectable		 6bqgA-4oe1A:
6.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ov6 PROPROTEIN
CONVERTASE
SUBTILISIN/KEXIN
TYPE 9

(Homo sapiens) 		PF00082
(Peptidase_S8) 		4 VAL B 333
THR B 335
LEU B 268
VAL B 252
 None
 0.94A 6bqgA-4ov6B:
undetectable		 6bqgA-4ov6B:
12.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pir 5-HYDROXYTRYPTAMINE
RECEPTOR 3A

(Mus musculus) 		PF02931
(Neur_chan_LBD)
PF02932
(Neur_chan_memb) 		4 THR A  90
LEU A 129
VAL A 106
LEU A  99
 None
 1.01A 6bqgA-4pirA:
1.4		 6bqgA-4pirA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2c CRISPR-ASSOCIATED
HELICASE CAS3

(Thermobaculum
terrenum) 		PF00271
(Helicase_C) 		4 VAL A 506
LEU A 494
VAL A 456
LEU A 469
 None
 0.95A 6bqgA-4q2cA:
undetectable		 6bqgA-4q2cA:
6.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qj4 1-PHOSPHATIDYLINOSIT
OL 4,5-BISPHOSPHATE
PHOSPHODIESTERASE
BETA-3

(Homo sapiens) 		PF00168
(C2)
PF00387
(PI-PLC-Y)
PF00388
(PI-PLC-X)
PF09279
(EF-hand_like) 		4 VAL B 747
THR B 764
LEU B 825
LEU B 811
 None
 1.00A 6bqgA-4qj4B:
undetectable		 6bqgA-4qj4B:
6.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wj3 ASPARTYL/GLUTAMYL-TR
NA(ASN/GLN)
AMIDOTRANSFERASE
SUBUNIT B
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT A
GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT C

(Pseudomonas
aeruginosa) 		PF01425
(Amidase)
PF02637
(GatB_Yqey)
PF02686
(Glu-tRNAGln)
PF02934
(GatB_N) 		4 VAL A 239
LEU B 279
VAL B 282
LEU C  62
 None
 0.85A 6bqgA-4wj3A:
undetectable		 6bqgA-4wj3A:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xgj UNCHARACTERIZED
PROTEIN

(Pectobacterium
atrosepticum) 		PF07005
(DUF1537)
PF17042
(DUF1357_C) 		4 VAL A 275
THR A 273
LEU A 346
LEU A 373
 None
 0.81A 6bqgA-4xgjA:
undetectable		 6bqgA-4xgjA:
10.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bmq ERFK/YBIS/YCFS/YNHG
FAMILY PROTEIN

(Stackebrandtia
nassauensis) 		PF03734
(YkuD) 		4 VAL A 212
THR A 214
VAL A 200
LEU A 288
 None
 1.00A 6bqgA-5bmqA:
undetectable		 6bqgA-5bmqA:
12.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cef ASPARTATE-SEMIALDEHY
DE DEHYDROGENASE

(Cryptococcus
neoformans) 		PF01118
(Semialdhyde_dh)
PF02774
(Semialdhyde_dhC) 		4 VAL A 180
THR A 182
LEU A 165
VAL A 128
 None
EDO  A 401 (-3.9A)
None
None
 1.00A 6bqgA-5cefA:
undetectable		 6bqgA-5cefA:
11.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dn7 PROTEIN FAM179B

(Mus musculus) 		no annotation 4 VAL A 564
LEU A 530
VAL A 490
LEU A 536
 None
 0.97A 6bqgA-5dn7A:
undetectable		 6bqgA-5dn7A:
13.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ej1 PUTATIVE CELLULOSE
SYNTHASE

(Rhodobacter
sphaeroides) 		PF00535
(Glycos_transf_2)
PF03170
(BcsB)
PF03552
(Cellulose_synt)
PF07238
(PilZ) 		4 THR B 581
LEU A  76
VAL A  53
LEU B 702
 None
 0.87A 6bqgA-5ej1B:
undetectable		 6bqgA-5ej1B:
9.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5emi CELL WALL
HYDROLASE/AUTOLYSIN

(Nostoc
punctiforme) 		PF01520
(Amidase_3) 		4 VAL A 441
LEU A 539
VAL A 530
LEU A 567
 None
 0.50A 6bqgA-5emiA:
undetectable		 6bqgA-5emiA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fkc BETA-FRUCTOFURANOSID
ASE

(Xanthophyllomyces
dendrorhous) 		PF00251
(Glyco_hydro_32N)
PF08244
(Glyco_hydro_32C) 		4 VAL A 543
THR A 557
LEU A 613
LEU A 577
 None
 1.02A 6bqgA-5fkcA:
undetectable		 6bqgA-5fkcA:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fo1 RIBOFLAVIN
BIOSYNTHESIS PROTEIN
RIBF

(Corynebacterium
ammoniagenes) 		PF01687
(Flavokinase)
PF06574
(FAD_syn) 		4 VAL A 311
THR A 314
LEU A 204
LEU A 303
 None
 0.96A 6bqgA-5fo1A:
undetectable		 6bqgA-5fo1A:
13.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gq0 EPITHIOSPECIFIER
PROTEIN

(Arabidopsis
thaliana) 		no annotation 4 VAL B 232
THR B 230
LEU B 281
VAL B 249
 None
 0.64A 6bqgA-5gq0B:
undetectable		 6bqgA-5gq0B:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h02 GLYCINE SARCOSINE
N-METHYLTRANSFERASE

(Methanohalophilus
portucalensis) 		PF13649
(Methyltransf_25) 		4 THR A 240
LEU A 149
VAL A  66
LEU A 156
 None
 0.95A 6bqgA-5h02A:
undetectable		 6bqgA-5h02A:
14.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hp5 PROTEIN-ARGININE
DEIMINASE TYPE-1

(Homo sapiens) 		PF03068
(PAD)
PF08526
(PAD_N)
PF08527
(PAD_M) 		4 VAL A 280
THR A 276
VAL A 115
LEU A 199
 None
 0.99A 6bqgA-5hp5A:
undetectable		 6bqgA-5hp5A:
8.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ict GLUTAMATE RECEPTOR 1

(Drosophila
melanogaster) 		PF10613
(Lig_chan-Glu_bd) 		4 VAL A 227
THR A 229
LEU A  44
LEU A  20
 None
 0.84A 6bqgA-5ictA:
undetectable		 6bqgA-5ictA:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jvk UNCHARACTERIZED
PROTEIN

(Bacteroides
cellulosilyticus) 		no annotation 4 VAL A  44
THR A  46
VAL A 134
LEU A 383
 None
 1.00A 6bqgA-5jvkA:
undetectable		 6bqgA-5jvkA:
8.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jzb 4,5:9,10-DISECO-3-HY
DROXY-5,9,17-TRIOXOA
NDROSTA-1(10),2-DIEN
E-4-OATE HYDROLASE

(Mycobacterium
tuberculosis) 		PF12697
(Abhydrolase_6) 		4 THR A  12
LEU A 103
VAL A 108
LEU A  96
 None
 1.02A 6bqgA-5jzbA:
undetectable		 6bqgA-5jzbA:
14.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k70 PROTEIN SIDEKICK-2

(Mus musculus) 		PF07679
(I-set)
PF13927
(Ig_3) 		4 VAL A 111
THR A 147
VAL A 276
LEU A 227
 None
 0.95A 6bqgA-5k70A:
undetectable		 6bqgA-5k70A:
12.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lvt DNA-BINDING PROTEIN
HU

(Lactococcus
lactis) 		no annotation 4 VAL A  11
THR A  15
VAL A  32
LEU A  45
 None
 0.99A 6bqgA-5lvtA:
undetectable		 6bqgA-5lvtA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mz9 -

(-) 		no annotation 4 VAL A 737
THR A 739
LEU A 776
VAL A  30
 None
 1.03A 6bqgA-5mz9A:
undetectable		 6bqgA-5mz9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nsq AMINOPEPTIDASE,
PUTATIVE

(Trypanosoma
brucei) 		PF00883
(Peptidase_M17) 		4 VAL A 187
LEU A  64
VAL A  71
LEU A  56
 None
 0.89A 6bqgA-5nsqA:
1.2		 6bqgA-5nsqA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ntf AMINOPEPTIDASE

(Trypanosoma
cruzi) 		PF00883
(Peptidase_M17) 		5 VAL A 186
THR A 184
LEU A  64
VAL A  71
LEU A  56
 None
 1.33A 6bqgA-5ntfA:
undetectable		 6bqgA-5ntfA:
9.42