SIMILAR PATTERNS OF AMINO ACIDS FOR 6BPY_A_ACTA408

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ad9 IGG CTM01 FAB (HEAVY
CHAIN)

(Homo sapiens) 		no annotation 3 PRO H 185
SER H 187
SER H 188
 None
 0.55A 6bpyA-1ad9H:
0.0		 6bpyA-1ad9H:
21.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1b8g PROTEIN
(1-AMINOCYCLOPROPANE
-1-CARBOXYLATE
SYNTHASE)

(Malus domestica) 		PF00155
(Aminotran_1_2) 		3 PRO A 394
SER A 396
SER A 397
 None
 0.69A 6bpyA-1b8gA:
0.0		 6bpyA-1b8gA:
20.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bbj IGG4-KAPPA B72.3 FAB
(HEAVY CHAIN)

(Homo sapiens;
Mus musculus) 		no annotation 3 PRO H 186
SER H 188
SER H 189
 None
 0.68A 6bpyA-1bbjH:
undetectable		 6bpyA-1bbjH:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bz7 PROTEIN (ANTIBODY
R24 (HEAVY CHAIN))

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PRO B 193
SER B 195
SER B 196
 None
 0.55A 6bpyA-1bz7B:
0.0		 6bpyA-1bz7B:
19.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c0i D-AMINO ACID OXIDASE

(Rhodotorula
toruloides) 		PF01266
(DAO) 		3 PRO A1119
SER A1120
SER A1121
 None
 0.65A 6bpyA-1c0iA:
8.7		 6bpyA-1c0iA:
22.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1c7o CYSTALYSIN

(Treponema
denticola) 		PF00155
(Aminotran_1_2) 		3 PRO A 375
SER A 376
SER A 377
 None
 0.70A 6bpyA-1c7oA:
0.0		 6bpyA-1c7oA:
22.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cly IGG FAB (HUMAN IGG1,
KAPPA)

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PRO H 194
SER H 196
SER H 197
 None
 0.27A 6bpyA-1clyH:
undetectable		 6bpyA-1clyH:
20.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1clz IGG FAB (IGG3,
KAPPA)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PRO H 194
SER H 195
SER H 196
 None
 0.64A 6bpyA-1clzH:
0.4		 6bpyA-1clzH:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fsk ANTIBODY HEAVY CHAIN
FAB

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PRO C 189
SER C 190
SER C 191
 None
 0.67A 6bpyA-1fskC:
0.0		 6bpyA-1fskC:
20.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ghf ANTI-ANTI-IDIOTYPE
GH1002 FAB FRAGMENT

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PRO H 186
SER H 187
SER H 188
 None
 0.68A 6bpyA-1ghfH:
undetectable		 6bpyA-1ghfH:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1gxs P-(S)-HYDROXYMANDELO
NITRILE LYASE CHAIN
B

(Sorghum bicolor) 		PF00450
(Peptidase_S10) 		3 PRO B 363
SER B 365
SER B 366
 None
 0.53A 6bpyA-1gxsB:
undetectable		 6bpyA-1gxsB:
16.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ibg IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PRO H 194
SER H 195
SER H 196
 None
 0.52A 6bpyA-1ibgH:
undetectable		 6bpyA-1ibgH:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ikf IGG1-KAPPA R45-45-11
FAB (HEAVY CHAIN)

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PRO H 197
SER H 198
SER H 199
 None
 0.70A 6bpyA-1ikfH:
undetectable		 6bpyA-1ikfH:
22.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jnn MONOCLONAL
ANTI-ESTRADIOL
17E12E5
IMMUNOGLOBULIN
GAMMA-1 CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PRO H 195
SER H 196
SER H 197
 None
 0.68A 6bpyA-1jnnH:
undetectable		 6bpyA-1jnnH:
21.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mco IGG1 MCG INTACT
ANTIBODY (HEAVY
CHAIN)

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PRO H 189
SER H 191
SER H 192
 None
 0.65A 6bpyA-1mcoH:
undetectable		 6bpyA-1mcoH:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o20 GAMMA-GLUTAMYL
PHOSPHATE REDUCTASE

(Thermotoga
maritima) 		PF00171
(Aldedh) 		3 PRO A 171
SER A 173
SER A 174
 None
 0.58A 6bpyA-1o20A:
2.1		 6bpyA-1o20A:
24.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t2s ARGONAUTE 2

(Drosophila
melanogaster) 		PF02170
(PAZ) 		3 PRO A  66
SER A  68
SER A  69
 None
 0.62A 6bpyA-1t2sA:
undetectable		 6bpyA-1t2sA:
17.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vge TR1.9 FAB

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PRO H 194
SER H 196
SER H 197
 None
 0.56A 6bpyA-1vgeH:
undetectable		 6bpyA-1vgeH:
23.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wfy REGULATOR OF
G-PROTEIN SIGNALING
14
RAP1/RAP2
INTERACTING PROTEIN

(Mus musculus) 		PF02196
(RBD) 		3 PRO A  74
SER A  76
SER A  77
 None
 0.65A 6bpyA-1wfyA:
undetectable		 6bpyA-1wfyA:
16.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ygp YEAST GLYCOGEN
PHOSPHORYLASE

(Saccharomyces
cerevisiae) 		PF00343
(Phosphorylase) 		3 PRO A 736
SER A 736
SER A 737
 None
 0.69A 6bpyA-1ygpA:
undetectable		 6bpyA-1ygpA:
18.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2b9b FUSION GLYCOPROTEIN
F0

(Mammalian
rubulavirus 5) 		PF00523
(Fusion_gly) 		3 PRO A 397
SER A 398
SER A 399
 None
 0.70A 6bpyA-2b9bA:
undetectable		 6bpyA-2b9bA:
20.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2cn3 BETA-1,4-XYLOGLUCAN
HYDROLASE

(Ruminiclostridium
thermocellum) 		PF02012
(BNR) 		3 PRO A 320
SER A 322
SER A 323
 None
 0.69A 6bpyA-2cn3A:
undetectable		 6bpyA-2cn3A:
19.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eoh ZINC FINGER PROTEIN
28 HOMOLOG

(Homo sapiens) 		no annotation 3 PRO A  43
SER A  44
SER A  45
 None
 0.66A 6bpyA-2eohA:
undetectable		 6bpyA-2eohA:
8.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fgw H52 FAB (HEAVY
CHAIN)

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PRO H 196
SER H 198
SER H 199
 None
 0.65A 6bpyA-2fgwH:
undetectable		 6bpyA-2fgwH:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ibb CG9211-PA

(Drosophila
melanogaster) 		PF00041
(fn3) 		3 PRO A 619
SER A 621
SER A 622
 None
 0.52A 6bpyA-2ibbA:
undetectable		 6bpyA-2ibbA:
20.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ri8 MANNOSYL-OLIGOSACCHA
RIDE
ALPHA-1,2-MANNOSIDAS
E

(Penicillium
citrinum) 		PF01532
(Glyco_hydro_47) 		3 PRO A1234
SER A1236
SER A1237
 None
 0.67A 6bpyA-2ri8A:
undetectable		 6bpyA-2ri8A:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vdw VACCINIA VIRUS
CAPPING ENZYME D1
SUBUNIT

(Vaccinia virus) 		PF03291
(Pox_MCEL) 		3 PRO A 733
SER A 734
SER A 735
 None
 0.62A 6bpyA-2vdwA:
undetectable		 6bpyA-2vdwA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vpj KELCH-LIKE PROTEIN
12

(Homo sapiens) 		PF01344
(Kelch_1) 		3 PRO A 364
SER A 345
SER A 344
 None
ACT  A1568 (-3.6A)
None
 0.62A 6bpyA-2vpjA:
undetectable		 6bpyA-2vpjA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xxl GRAM-POSITIVE
SPECIFIC SERINE
PROTEASE, ISOFORM B

(Drosophila
melanogaster) 		PF00089
(Trypsin)
PF12032
(CLIP) 		3 PRO A  44
SER A  46
SER A  47
 None
 0.51A 6bpyA-2xxlA:
undetectable		 6bpyA-2xxlA:
23.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eyf AD-2

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PRO B 197
SER B 199
SER B 200
 None
 0.48A 6bpyA-3eyfB:
undetectable		 6bpyA-3eyfB:
21.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hy8 PYRIDOXINE-5'-PHOSPH
ATE OXIDASE

(Homo sapiens) 		PF01243
(Putative_PNPOx)
PF10590
(PNP_phzG_C) 		3 PRO A 162
SER A 164
SER A 165
 PLP  A 350 (-4.4A)
None
PLP  A 350 (-3.1A)
 0.63A 6bpyA-3hy8A:
undetectable		 6bpyA-3hy8A:
21.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3i9g SONEPCIZUMAB
ANTIBODY FAB
FRAGMENT, HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PRO H 185
SER H 187
SER H 188
 None
 0.58A 6bpyA-3i9gH:
undetectable		 6bpyA-3i9gH:
18.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3le4 MICROPROCESSOR
COMPLEX SUBUNIT
DGCR8

(Homo sapiens) 		no annotation 3 PRO A 346
SER A 348
SER A 349
 None
 0.66A 6bpyA-3le4A:
undetectable		 6bpyA-3le4A:
11.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mlw HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 1006-15D
FAB HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PRO H 185
SER H 187
SER H 188
 None
 0.61A 6bpyA-3mlwH:
undetectable		 6bpyA-3mlwH:
21.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mnz ANTI-HIV-1 ANTIBODY
13H11 HEAVY CHAIN

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PRO B 194
SER B 196
SER B 197
 None
 0.49A 6bpyA-3mnzB:
undetectable		 6bpyA-3mnzB:
19.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n4x MONOPOLIN COMPLEX
SUBUNIT CSM1

(Saccharomyces
cerevisiae) 		PF12539
(Csm1) 		3 PRO A 164
SER A 166
SER A 167
 None
 0.61A 6bpyA-3n4xA:
undetectable		 6bpyA-3n4xA:
17.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nab FAB15 MUT6 HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PRO H 185
SER H 187
SER H 188
 None
 0.54A 6bpyA-3nabH:
undetectable		 6bpyA-3nabH:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzh 5F6 HEAVY CHAIN

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PRO H 189
SER H 191
SER H 192
 None
 0.47A 6bpyA-3nzhH:
undetectable		 6bpyA-3nzhH:
19.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3opy 6-PHOSPHOFRUCTO-1-KI
NASE ALPHA-SUBUNIT

(Komagataella
pastoris) 		PF00365
(PFK) 		3 PRO A 594
SER A 596
SER A 597
 None
 0.69A 6bpyA-3opyA:
2.4		 6bpyA-3opyA:
17.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qeh FAB FRAGMENT OF
HUMAN ANTI-HIV-1 ENV
ANTIBODY N12-I15,
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PRO A 185
SER A 187
SER A 188
 None
 0.56A 6bpyA-3qehA:
undetectable		 6bpyA-3qehA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qht MONOBODY YSMB-1

(synthetic
construct) 		PF00041
(fn3) 		3 PRO C  51
SER C  53
SER C  54
 None
 0.69A 6bpyA-3qhtC:
undetectable		 6bpyA-3qhtC:
13.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3s6h N-ACETYLGLUTAMATE
KINASE /
N-ACETYLGLUTAMATE
SYNTHASE

(Maricaulis
maris) 		PF00696
(AA_kinase)
PF04768
(NAT) 		3 PRO A 261
SER A 263
SER A 264
 None
 0.42A 6bpyA-3s6hA:
undetectable		 6bpyA-3s6hA:
23.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3teu FIBCON

(-) 		PF00041
(fn3) 		3 PRO A  51
SER A  53
SER A  54
 None
 0.67A 6bpyA-3teuA:
undetectable		 6bpyA-3teuA:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3u7g BIFUNCTIONAL
POLYNUCLEOTIDE
PHOSPHATASE/KINASE

(Mus musculus) 		PF08645
(PNK3P)
PF13671
(AAA_33) 		3 PRO A 354
SER A 356
SER A 357
 None
 0.69A 6bpyA-3u7gA:
undetectable		 6bpyA-3u7gA:
24.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ut3 PLASMINOGEN
ACTIVATOR INHIBITOR
1

(Homo sapiens) 		PF00079
(Serpin) 		3 PRO A 180
SER A 182
SER A 183
 None
 0.55A 6bpyA-3ut3A:
undetectable		 6bpyA-3ut3A:
22.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cni OLOKIZUMAB HEAVY
CHAIN, FAB PORTION

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PRO A 192
SER A 194
SER A 195
 None
 0.59A 6bpyA-4cniA:
undetectable		 6bpyA-4cniA:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d90 EGF-LIKE REPEAT AND
DISCOIDIN I-LIKE
DOMAIN-CONTAINING
PROTEIN 3

(Homo sapiens) 		PF00008
(EGF) 		3 PRO A  57
SER A  60
SER A  61
 None
 0.53A 6bpyA-4d90A:
undetectable		 6bpyA-4d90A:
15.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4f15 FAB FRAGMENT, HEAVY
CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PRO B 193
SER B 195
SER B 196
 None
 0.61A 6bpyA-4f15B:
undetectable		 6bpyA-4f15B:
22.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fp8 ANTIBODY C05, HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PRO H 185
SER H 187
SER H 188
 None
 0.55A 6bpyA-4fp8H:
undetectable		 6bpyA-4fp8H:
21.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fz8 FAB HEAVY CHAIN OF
HUMAN ANTI-HIV-1 ENV
ANTIBODY C11

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PRO H 185
SER H 187
SER H 188
 None
 0.61A 6bpyA-4fz8H:
undetectable		 6bpyA-4fz8H:
21.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jpw HEAVY CHAIN OF
ANTIBODY 12A21

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PRO H 185
SER H 187
SER H 188
 None
 0.67A 6bpyA-4jpwH:
undetectable		 6bpyA-4jpwH:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kuz ANTIBODY 4A5 HEAVY
CHAIN

(Homo sapiens;
Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PRO H 192
SER H 194
SER H 195
 None
 0.52A 6bpyA-4kuzH:
undetectable		 6bpyA-4kuzH:
22.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lly MUTATED PERTUZUMAB
FAB HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PRO A 191
SER A 193
SER A 194
 None
 0.61A 6bpyA-4llyA:
undetectable		 6bpyA-4llyA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o4y 2095-2 HEAVY CHAIN

(Homo sapiens;
Oryctolagus
cuniculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PRO H 186
SER H 188
SER H 189
 None
 0.42A 6bpyA-4o4yH:
undetectable		 6bpyA-4o4yH:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ocs CAP256-VRC26.10
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PRO H 185
SER H 187
SER H 188
 None
 0.68A 6bpyA-4ocsH:
undetectable		 6bpyA-4ocsH:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pln NEOGENIN

(Mus musculus) 		PF00041
(fn3) 		3 PRO C 832
SER C 833
SER C 834
 None
 0.65A 6bpyA-4plnC:
undetectable		 6bpyA-4plnC:
18.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4r12 PUTATIVE
UNCHARACTERIZED
PROTEIN

(Dictyostelium
purpureum) 		PF05450
(Nicastrin) 		3 PRO A 547
SER A 548
SER A 549
 None
 0.53A 6bpyA-4r12A:
1.2		 6bpyA-4r12A:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u5x RAC-LIKE GTP-BINDING
PROTEIN 1

(Oryza sativa) 		PF00071
(Ras) 		3 PRO A 137
SER A 139
SER A 140
 None
 0.60A 6bpyA-4u5xA:
undetectable		 6bpyA-4u5xA:
19.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xml HEAVY CHAIN OF HIV-1
GP120 V3-SPECIFIC
HUMAN MONOCLONAL
ANTIBODY 2424

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PRO H 185
SER H 187
SER H 188
 None
 0.69A 6bpyA-4xmlH:
undetectable		 6bpyA-4xmlH:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xyi KINETOCHORE PROTEIN
MIS16

(Schizosaccharomyces
japonicus) 		PF00400
(WD40)
PF12265
(CAF1C_H4-bd) 		3 PRO A 265
SER A 267
SER A 268
 None
 0.65A 6bpyA-4xyiA:
undetectable		 6bpyA-4xyiA:
21.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yc2 THE ANTIBODY A32 FAB
HEAVY CHAIN.

(Homo sapiens) 		no annotation 3 PRO H 185
SER H 187
SER H 188
 None
 0.60A 6bpyA-4yc2H:
undetectable		 6bpyA-4yc2H:
20.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z8t AVRRXO1-ORF1

(Xanthomonas
oryzae) 		no annotation 3 PRO A 192
SER A 219
SER A 218
 None
 0.63A 6bpyA-4z8tA:
undetectable		 6bpyA-4z8tA:
21.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5b64 PROTEIN KIF13B

(Mus musculus) 		PF12423
(KIF1B) 		3 PRO B 720
SER B 722
SER B 723
 None
 0.61A 6bpyA-5b64B:
undetectable		 6bpyA-5b64B:
15.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5brr TISSUE-TYPE
PLASMINOGEN
ACTIVATOR

(Homo sapiens) 		PF00089
(Trypsin) 		3 PRO E 164
SER E 165
SER E 166
 GOL  E 303 ( 4.6A)
None
GOL  E 303 ( 4.0A)
 0.69A 6bpyA-5brrE:
undetectable		 6bpyA-5brrE:
21.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dmg RB86 ANTIBODY FAB
FRAGMENT HEAVY CHAIN

(Oryctolagus
cuniculus) 		no annotation 3 PRO H1071
SER H1073
SER H1074
 None
 0.69A 6bpyA-5dmgH:
undetectable		 6bpyA-5dmgH:
20.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e94 ANTIBODY FAB
FRAGMENT HEAVY CHAIN

(Mus musculus) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PRO B 195
SER B 197
SER B 198
 None
 0.61A 6bpyA-5e94B:
undetectable		 6bpyA-5e94B:
21.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ew5 COLICIN-E9

(Escherichia
coli) 		PF03515
(Cloacin) 		3 PRO A 169
SER A 171
SER A 172
 None
 0.50A 6bpyA-5ew5A:
undetectable		 6bpyA-5ew5A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f9o CH235.9 HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PRO H 194
SER H 196
SER H 197
 None
 0.66A 6bpyA-5f9oH:
undetectable		 6bpyA-5f9oH:
19.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ies VRC01CHUGL2 FAB
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PRO H 185
SER H 187
SER H 188
 None
 0.68A 6bpyA-5iesH:
undetectable		 6bpyA-5iesH:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kw9 IGA(VH)-IGG(CH)
HEAVY CHAIN FAB
FRAGMENT

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PRO H 196
SER H 198
SER H 199
 None
 0.56A 6bpyA-5kw9H:
undetectable		 6bpyA-5kw9H:
21.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lfr MYELIN-ASSOCIATED
GLYCOPROTEIN

(Mus musculus) 		PF08205
(C2-set_2)
PF13927
(Ig_3) 		3 PRO A  27
SER A  28
SER A 133
 None
 0.63A 6bpyA-5lfrA:
undetectable		 6bpyA-5lfrA:
21.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5m59 PRE-MRNA SPLICING
HELICASE-LIKE
PROTEIN

(Chaetomium
thermophilum) 		PF00270
(DEAD)
PF00271
(Helicase_C)
PF02889
(Sec63) 		3 PRO A1198
SER A1200
SER A1201
 None
 0.54A 6bpyA-5m59A:
undetectable		 6bpyA-5m59A:
11.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5nbi DESIGN OF ANTIBODIES

(Escherichia
coli) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PRO H 193
SER H 195
SER H 196
 None
 0.58A 6bpyA-5nbiH:
undetectable		 6bpyA-5nbiH:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5o0l RETICULON-4 RECEPTOR

(Mus musculus) 		no annotation 3 PRO A  56
SER A  58
SER A  59
 None
 0.68A 6bpyA-5o0lA:
undetectable		 6bpyA-5o0lA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5szq PROTOCADHERIN
GAMMA-A4

(Mus musculus) 		PF00028
(Cadherin) 		3 PRO A 472
SER A 474
SER A 475
 None
 0.49A 6bpyA-5szqA:
undetectable		 6bpyA-5szqA:
20.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u3p DH511.4 FAB HEAVY
CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PRO H 185
SER H 187
SER H 188
 None
 0.65A 6bpyA-5u3pH:
undetectable		 6bpyA-5u3pH:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5v6m HEAVY CHAIN OF FAB
FRAGMENT OF RABBIT
ANTI-HIV1 GP120 V3
MAB 10A3

(Oryctolagus
cuniculus) 		no annotation 3 PRO H 181
SER H 183
SER H 184
 None
 0.50A 6bpyA-5v6mH:
undetectable		 6bpyA-5v6mH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vig FAB HEAVY CHAIN

(Homo sapiens) 		no annotation 3 PRO H 185
SER H 187
SER H 188
 None
 0.64A 6bpyA-5vigH:
undetectable		 6bpyA-5vigH:
19.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vta FAB HEAVY CHAIN

(Mus musculus) 		no annotation 3 PRO H 188
SER H 190
SER H 191
 None
 0.52A 6bpyA-5vtaH:
undetectable		 6bpyA-5vtaH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5w1k CR1-10 FAB HEAVY
CHAIN

(Homo sapiens) 		no annotation 3 PRO D 198
SER D 200
SER D 201
 None
 0.63A 6bpyA-5w1kD:
undetectable		 6bpyA-5w1kD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wb0 FUSION GLYCOPROTEIN
F0

(Human
metapneumovirus) 		no annotation 3 PRO F 441
SER F 443
SER F 444
 None
 0.65A 6bpyA-5wb0F:
undetectable		 6bpyA-5wb0F:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wb9 N60P23 FAB HEAVY
CHAIN

(Homo sapiens) 		no annotation 3 PRO H 192
SER H 194
SER H 195
 None
 0.65A 6bpyA-5wb9H:
undetectable		 6bpyA-5wb9H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wcd VRC315 04-1D02 FAB
HEAVY CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PRO H 196
SER H 198
SER H 199
 None
 0.48A 6bpyA-5wcdH:
undetectable		 6bpyA-5wcdH:
21.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xnr ALYQ

(Persicobacter
sp. CCB-QB2) 		no annotation 3 PRO A 386
SER A 388
SER A 389
 None
 0.63A 6bpyA-5xnrA:
undetectable		 6bpyA-5xnrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ygf GH18329P

(Drosophila
melanogaster) 		no annotation 3 PRO A 399
SER A 401
SER A 402
 None
 0.69A 6bpyA-5ygfA:
undetectable		 6bpyA-5ygfA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z7r SHORT-CHAIN-ENOYL-CO
A HYDRATASE

(Clostridium
acetobutylicum) 		no annotation 3 PRO A 185
SER A 126
SER A 125
 None
 0.67A 6bpyA-5z7rA:
undetectable		 6bpyA-5z7rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bck N49P7 FAB HEAVY
CHAIN OF N29P7 IGG

(Homo sapiens) 		no annotation 3 PRO H 185
SER H 187
SER H 188
 None
 0.70A 6bpyA-6bckH:
undetectable		 6bpyA-6bckH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bf4 VRC-PG05 FAB HEAVY
CHAIN

(Homo sapiens) 		no annotation 3 PRO B 185
SER B 187
SER B 188
 None
 0.60A 6bpyA-6bf4B:
undetectable		 6bpyA-6bf4B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bja ACETYL-COA
ACETYLTRANSFERASE A

(Ascaris suum) 		no annotation 3 PRO A  80
SER A  82
SER A  83
 None
 0.68A 6bpyA-6bjaA:
undetectable		 6bpyA-6bjaA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c26 DOLICHYL-DIPHOSPHOOL
IGOSACCHARIDE--PROTE
IN
GLYCOSYLTRANSFERASE
SUBUNIT 1

(Saccharomyces
cerevisiae) 		no annotation 3 PRO 1 442
SER 1 444
SER 1 445
 None
 0.54A 6bpyA-6c261:
undetectable		 6bpyA-6c261:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ca6 PCT64_35S HEAVY
CHAIN

(Homo sapiens) 		no annotation 3 PRO H 185
SER H 187
SER H 188
 None
 0.25A 6bpyA-6ca6H:
undetectable		 6bpyA-6ca6H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ca7 PCT64_13C HEAVY
CHAIN

(Homo sapiens) 		no annotation 3 PRO H 185
SER H 187
SER H 188
 None
 0.64A 6bpyA-6ca7H:
undetectable		 6bpyA-6ca7H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6d0k MONOBODY

(synthetic
construct) 		no annotation 3 PRO D  53
SER D  55
SER D  56
 None
 0.53A 6bpyA-6d0kD:
undetectable		 6bpyA-6d0kD:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoq DIPEPTIDYL PEPTIDASE
9

(Homo sapiens) 		no annotation 3 PRO A 341
SER A 343
SER A 344
 None
 0.63A 6bpyA-6eoqA:
undetectable		 6bpyA-6eoqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eyn -

(-) 		no annotation 3 PRO H 191
SER H 193
SER H 194
 None
 0.70A 6bpyA-6eynH:
undetectable		 6bpyA-6eynH:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6fc3 EUKARYOTIC
TRANSLATION
INITIATION FACTOR 4E

(Saccharomyces
cerevisiae) 		no annotation 3 PRO A 198
SER A 200
SER A 201
 None
 0.29A 6bpyA-6fc3A:
undetectable		 6bpyA-6fc3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gct NEUTRAL AMINO ACID
TRANSPORTER B(0)

(Homo sapiens) 		no annotation 3 PRO A 432
SER A 352
SER A 351
 None
 0.41A 6bpyA-6gctA:
undetectable		 6bpyA-6gctA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ghc -

(-) 		no annotation 3 PRO A 232
SER A 234
SER A 235
 None
 0.39A 6bpyA-6ghcA:
undetectable		 6bpyA-6ghcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
8fab IGG1-LAMBDA HIL FAB
(HEAVY CHAIN)

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PRO B 193
SER B 194
SER B 195
 None
 0.58A 6bpyA-8fabB:
undetectable		 6bpyA-8fabB:
21.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
8fab IGG1-LAMBDA HIL FAB
(HEAVY CHAIN)

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 PRO B 193
SER B 195
SER B 196
 None
 0.69A 6bpyA-8fabB:
undetectable		 6bpyA-8fabB:
21.87