SIMILAR PATTERNS OF AMINO ACIDS FOR 6BP4_B_SAMB505
List of similar pattern of amino acids derived from ASSAM searchHit | Macromolecule/ Organism |
Pfam | Res. | Interface | HETATM | RMSD | Dali Z-score | Seq. Identity (%) | View | Dock | |
---|---|---|---|---|---|---|---|---|---|---|---|
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1ewi | REPLICATION PROTEINA (Homo sapiens) |
PF04057(Rep-A_N) | 5 | GLY A 49ILE A 10CYH A 77CYH A 75LEU A 25 | None | 1.49A | 6bp4B-1ewiA:undetectable | 6bp4B-1ewiA:15.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1k2f | SIAH-1A PROTEIN (Mus musculus) |
PF03145(Sina) | 5 | GLY A 213HIS A 147CYH A 128CYH A 130GLY A 139 | None ZN A 601 (-3.0A) ZN A 601 (-2.1A)BME A 550 (-2.1A)None | 1.27A | 6bp4B-1k2fA:undetectable | 6bp4B-1k2fA:20.14 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1mvh | CRYPTIC LOCIREGULATOR 4 (Schizosaccharomycespombe) |
PF00856(SET)PF05033(Pre-SET) | 5 | LYS A 338GLY A 339TRP A 340TYR A 381HIS A 410 | None | 0.88A | 6bp4B-1mvhA:34.9 | 6bp4B-1mvhA:100.00 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1peg | HISTONE H3METHYLTRANSFERASEDIM-5 (Neurosporacrassa) |
PF00856(SET)PF05033(Pre-SET) | 5 | GLY A 146TYR A 104CYH A 138CYH A 128GLY A 112 | NoneNone ZN A 2 (-2.3A) ZN A 2 ( 2.3A)None | 1.02A | 6bp4B-1pegA:28.3 | 6bp4B-1pegA:37.76 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1peg | HISTONE H3METHYLTRANSFERASEDIM-5 (Neurosporacrassa) |
PF00856(SET)PF05033(Pre-SET) | 8 | GLY A 160TRP A 161TYR A 204HIS A 242TYR A 283CYH A 306CYH A 308LEU A 317 | SAH A 319 ( 4.6A)SAH A 319 (-4.8A)SAH A 319 (-4.0A)SAH A 319 (-4.3A)SAH A 319 (-4.7A) ZN A 4 ( 2.3A) ZN A 4 (-2.2A)SAH A 319 (-3.9A) | 0.85A | 6bp4B-1pegA:28.3 | 6bp4B-1pegA:37.76 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 1peg | HISTONE H3METHYLTRANSFERASEDIM-5 (Neurosporacrassa) |
PF00856(SET)PF05033(Pre-SET) | 6 | GLY A 160TRP A 161TYR A 204HIS A 242TYR A 283CYH A 308 | SAH A 319 ( 4.6A)SAH A 319 (-4.8A)SAH A 319 (-4.0A)SAH A 319 (-4.3A)SAH A 319 (-4.7A) ZN A 4 (-2.2A) | 1.21A | 6bp4B-1pegA:28.3 | 6bp4B-1pegA:37.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1pk9 | PURINE NUCLEOSIDEPHOSPHORYLASE (Escherichiacoli) |
PF01048(PNP_UDP_1) | 5 | GLY A 89ILE A 199TYR A 186LEU A 153GLY A 106 | PO4 A 309 (-3.5A)NoneNoneNoneNone | 1.41A | 6bp4B-1pk9A:undetectable | 6bp4B-1pk9A:20.13 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1rrm | LACTALDEHYDEREDUCTASE (Escherichiacoli) |
PF00465(Fe-ADH) | 5 | ILE A 206HIS A 263CYH A 362LEU A 259GLY A 204 | None ZN A 387 ( 3.3A)FE2 A 388 (-2.4A)FE2 A 388 ( 4.1A)None | 1.43A | 6bp4B-1rrmA:undetectable | 6bp4B-1rrmA:19.80 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 1to6 | GLYCERATE KINASE (Neisseriameningitidis) |
PF02595(Gly_kinase) | 5 | ILE A 247TYR A 228CYH A 197LEU A 196GLY A 249 | None | 1.11A | 6bp4B-1to6A:undetectable | 6bp4B-1to6A:21.96 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2atp | T-CELL SURFACEGLYCOPROTEIN CD8ALPHA CHAINT-CELL SURFACEGLYCOPROTEIN CD8BETA CHAIN (Mus musculus;Mus musculus) |
PF07686(V-set)PF07686(V-set) | 5 | LYS B 103GLY B 100ILE A 105TYR B 32LEU A 39 | None | 1.09A | 6bp4B-2atpB:undetectable | 6bp4B-2atpB:15.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2dwu | GLUTAMATE RACEMASE (Bacillusanthracis) |
PF01177(Asp_Glu_race) | 5 | ILE A 185TYR A 130HIS A 146LEU A 176GLY A 117 | None | 1.32A | 6bp4B-2dwuA:undetectable | 6bp4B-2dwuA:21.16 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2e0p | ENDOGLUCANASE (Ruminiclostridiumthermocellum) |
PF12891(Glyco_hydro_44) | 5 | GLY A 229ILE A 227TYR A 104LEU A 106GLY A 180 | None | 1.34A | 6bp4B-2e0pA:undetectable | 6bp4B-2e0pA:19.54 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fzw | ALCOHOLDEHYDROGENASE CLASSIII CHI CHAIN (Homo sapiens) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | GLY A 178HIS A 66TYR A 92CYH A 44GLY A 172 | None ZN A 376 (-3.3A)None ZN A 376 (-2.4A)None | 1.48A | 6bp4B-2fzwA:undetectable | 6bp4B-2fzwA:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fzw | ALCOHOLDEHYDROGENASE CLASSIII CHI CHAIN (Homo sapiens) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | GLY A 178HIS A 66TYR A 92LEU A 67GLY A 172 | None ZN A 376 (-3.3A)NoneNoneNone | 1.43A | 6bp4B-2fzwA:undetectable | 6bp4B-2fzwA:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2fzw | ALCOHOLDEHYDROGENASE CLASSIII CHI CHAIN (Homo sapiens) |
PF00107(ADH_zinc_N)PF08240(ADH_N) | 5 | GLY A 201ILE A 175HIS A 66LEU A 67GLY A 172 | NAD A1377 (-3.8A)None ZN A 376 (-3.3A)NoneNone | 1.28A | 6bp4B-2fzwA:undetectable | 6bp4B-2fzwA:20.51 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2i00 | ACETYLTRANSFERASE,GNAT FAMILY (Enterococcusfaecalis) |
PF13527(Acetyltransf_9)PF13530(SCP2_2) | 5 | GLY A 64TRP A 65ILE A 75LEU A 57GLY A 96 | None | 1.39A | 6bp4B-2i00A:undetectable | 6bp4B-2i00A:21.73 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2kg5 | ARF-GAP, RHO-GAPDOMAIN, ANK REPEATAND PHDOMAIN-CONTAININGPROTEIN 3 (Homo sapiens) |
PF07647(SAM_2) | 5 | GLY A 73ILE A 69TYR A 41ARG A 75LEU A 79 | None | 1.40A | 6bp4B-2kg5A:undetectable | 6bp4B-2kg5A:16.50 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2pfk | 6-PHOSPHOFRUCTOKINASE ISOZYME I (Escherichiacoli) |
PF00365(PFK) | 5 | GLY A 268ILE A 137TYR A 106CYH A 119GLY A 101 | None | 1.10A | 6bp4B-2pfkA:undetectable | 6bp4B-2pfkA:22.19 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2r3a | HISTONE-LYSINEN-METHYLTRANSFERASESUV39H2 (Homo sapiens) |
PF00856(SET)PF05033(Pre-SET) | 8 | GLY A 151TRP A 152TYR A 193HIS A 220TYR A 261CYH A 287CYH A 289LEU A 298 | SAM A 304 (-3.5A)NoneSAM A 304 (-4.2A)SAM A 304 (-4.9A)SAM A 304 (-4.9A) ZN A 300 ( 2.3A) ZN A 300 ( 2.3A)SAM A 304 (-4.7A) | 0.63A | 6bp4B-2r3aA:29.3 | 6bp4B-2r3aA:38.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2r3a | HISTONE-LYSINEN-METHYLTRANSFERASESUV39H2 (Homo sapiens) |
PF00856(SET)PF05033(Pre-SET) | 6 | GLY A 151TRP A 152TYR A 193HIS A 220TYR A 261CYH A 289 | SAM A 304 (-3.5A)NoneSAM A 304 (-4.2A)SAM A 304 (-4.9A)SAM A 304 (-4.9A) ZN A 300 ( 2.3A) | 1.48A | 6bp4B-2r3aA:29.3 | 6bp4B-2r3aA:38.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2r3a | HISTONE-LYSINEN-METHYLTRANSFERASESUV39H2 (Homo sapiens) |
PF00856(SET)PF05033(Pre-SET) | 6 | GLY A 153TYR A 193HIS A 220TYR A 261CYH A 287CYH A 289 | NoneSAM A 304 (-4.2A)SAM A 304 (-4.9A)SAM A 304 (-4.9A) ZN A 300 ( 2.3A) ZN A 300 ( 2.3A) | 1.49A | 6bp4B-2r3aA:29.3 | 6bp4B-2r3aA:38.44 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2r3a | HISTONE-LYSINEN-METHYLTRANSFERASESUV39H2 (Homo sapiens) |
PF00856(SET)PF05033(Pre-SET) | 5 | GLY A 153TYR A 193HIS A 220TYR A 261CYH A 289 | NoneSAM A 304 (-4.2A)SAM A 304 (-4.9A)SAM A 304 (-4.9A) ZN A 300 ( 2.3A) | 1.17A | 6bp4B-2r3aA:29.3 | 6bp4B-2r3aA:38.44 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 2vx4 | CELLVIBRIO JAPONICUSMANNANASE CJMAN26C (Cellvibriojaponicus) |
PF02156(Glyco_hydro_26) | 5 | GLY A 164TYR A 189HIS A 156LEU A 129GLY A 120 | NoneNoneGOL A1420 ( 4.1A)GOL A1420 (-4.1A)None | 1.22A | 6bp4B-2vx4A:undetectable | 6bp4B-2vx4A:21.14 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2w5z | HISTONE-LYSINEN-METHYLTRANSFERASEHRX (Homo sapiens) |
PF00856(SET) | 6 | GLY A3840TYR A3883HIS A3907TYR A3944CYH A3957CYH A3959 | SAH A4971 ( 3.7A)NoneSAH A4971 (-4.7A)SAH A4971 (-4.9A) ZN A4970 ( 2.3A) ZN A4970 (-2.3A) | 0.67A | 6bp4B-2w5zA:12.0 | 6bp4B-2w5zA:30.26 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2w5z | HISTONE-LYSINEN-METHYLTRANSFERASEHRX (Homo sapiens) |
PF00856(SET) | 5 | GLY A3842TYR A3883HIS A3907TYR A3944CYH A3959 | NoneNoneSAH A4971 (-4.7A)SAH A4971 (-4.9A) ZN A4970 (-2.3A) | 1.35A | 6bp4B-2w5zA:12.0 | 6bp4B-2w5zA:30.26 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 2w5z | HISTONE-LYSINEN-METHYLTRANSFERASEHRX (Homo sapiens) |
PF00856(SET) | 5 | HIS A3907TYR A3944CYH A3957CYH A3959LEU A3968 | SAH A4971 (-4.7A)SAH A4971 (-4.9A) ZN A4970 ( 2.3A) ZN A4970 (-2.3A)SAH A4971 ( 4.9A) | 0.40A | 6bp4B-2w5zA:12.0 | 6bp4B-2w5zA:30.26 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3aka | PUTATIVE CALCIUMBINDING PROTEIN (Streptomycescoelicolor) |
PF13499(EF-hand_7)PF13833(EF-hand_8) | 5 | GLY A 42TYR A 54ARG A 49LEU A 53GLY A 50 | None | 1.32A | 6bp4B-3akaA:undetectable | 6bp4B-3akaA:19.53 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3bo5 | HISTONE-LYSINEN-METHYLTRANSFERASESETMAR (Homo sapiens) |
PF00856(SET)PF05033(Pre-SET) | 6 | GLY A 138TYR A 178HIS A 210TYR A 248CYH A 273CYH A 275 | NoneSAH A 305 (-4.0A)NoneSAH A 305 (-4.9A) ZN A 304 ( 2.3A) ZN A 304 ( 2.3A) | 1.33A | 6bp4B-3bo5A:26.0 | 6bp4B-3bo5A:32.92 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3bo5 | HISTONE-LYSINEN-METHYLTRANSFERASESETMAR (Homo sapiens) |
PF00856(SET)PF05033(Pre-SET) | 5 | GLY A 138TYR A 178HIS A 210TYR A 248CYH A 275 | NoneSAH A 305 (-4.0A)NoneSAH A 305 (-4.9A) ZN A 304 ( 2.3A) | 0.90A | 6bp4B-3bo5A:26.0 | 6bp4B-3bo5A:32.92 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3bo5 | HISTONE-LYSINEN-METHYLTRANSFERASESETMAR (Homo sapiens) |
PF00856(SET)PF05033(Pre-SET) | 9 | LYS A 135GLY A 136TRP A 137TYR A 178HIS A 210TYR A 248CYH A 273CYH A 275LEU A 284 | NoneSAH A 305 (-3.8A)NoneSAH A 305 (-4.0A)NoneSAH A 305 (-4.9A) ZN A 304 ( 2.3A) ZN A 304 ( 2.3A)SAH A 305 (-4.5A) | 0.50A | 6bp4B-3bo5A:26.0 | 6bp4B-3bo5A:32.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ctt | MALTASE-GLUCOAMYLASE (Homo sapiens) |
PF00088(Trefoil)PF01055(Glyco_hydro_31)PF16863(NtCtMGAM_N) | 5 | TRP A 674ILE A 554HIS A 538LEU A 540GLY A 556 | None | 1.36A | 6bp4B-3cttA:undetectable | 6bp4B-3cttA:17.17 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gdc | MULTICOPPER OXIDASE (Arthrobactersp. FB24) |
PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 5 | GLY A 138ILE A 162HIS A 104LEU A 141GLY A 160 | NoneNone CU A 303 ( 3.2A)NoneNone | 1.48A | 6bp4B-3gdcA:undetectable | 6bp4B-3gdcA:22.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3gdc | MULTICOPPER OXIDASE (Arthrobactersp. FB24) |
PF07731(Cu-oxidase_2)PF07732(Cu-oxidase_3) | 5 | GLY A 245ILE A 162HIS A 104LEU A 141GLY A 160 | NoneNone CU A 303 ( 3.2A)NoneNone | 1.35A | 6bp4B-3gdcA:undetectable | 6bp4B-3gdcA:22.78 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3git | CARBON MONOXIDEDEHYDROGENASE/ACETYL-COA SYNTHASESUBUNIT ALPHA (Moorellathermoacetica) |
PF03598(CdhC) | 5 | GLY A 638ILE A 635CYH A 506LEU A 527GLY A 646 | NoneNoneSF4 A 738 (-2.3A)SF4 A 738 (-4.0A)None | 1.46A | 6bp4B-3gitA:undetectable | 6bp4B-3gitA:20.27 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3iwk | AMINOALDEHYDEDEHYDROGENASE (Pisum sativum) |
PF00171(Aldedh) | 5 | LYS A 245GLY A 243ILE A 158HIS A 219GLY A 222 | NAD A 505 (-2.7A)NoneNoneNoneNAD A 505 (-3.8A) | 1.20A | 6bp4B-3iwkA:undetectable | 6bp4B-3iwkA:19.21 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3lpp | SUCRASE-ISOMALTASE (Homo sapiens) |
PF00088(Trefoil)PF01055(Glyco_hydro_31)PF16863(NtCtMGAM_N) | 5 | TRP A 703ILE A 583HIS A 567LEU A 569GLY A 585 | None | 1.39A | 6bp4B-3lppA:undetectable | 6bp4B-3lppA:14.93 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n71 | HISTONE LYSINEMETHYLTRANSFERASESMYD1 (Mus musculus) |
PF00856(SET)PF01753(zf-MYND) | 5 | GLY A 16HIS A 206TYR A 252CYH A 274CYH A 276 | NoneNoneSFG A 491 (-4.8A) ZN A 497 (-2.2A) ZN A 497 (-2.5A) | 0.94A | 6bp4B-3n71A:5.5 | 6bp4B-3n71A:18.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n71 | HISTONE LYSINEMETHYLTRANSFERASESMYD1 (Mus musculus) |
PF00856(SET)PF01753(zf-MYND) | 5 | LYS A 17GLY A 18HIS A 206TYR A 252CYH A 274 | SFG A 491 (-4.7A)SFG A 491 ( 4.2A)NoneSFG A 491 (-4.8A) ZN A 497 (-2.2A) | 0.85A | 6bp4B-3n71A:5.5 | 6bp4B-3n71A:18.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3n71 | HISTONE LYSINEMETHYLTRANSFERASESMYD1 (Mus musculus) |
PF00856(SET)PF01753(zf-MYND) | 5 | LYS A 17GLY A 18HIS A 206TYR A 252CYH A 274 | SFG A 491 (-4.7A)SFG A 491 ( 4.2A)NoneSFG A 491 (-4.8A) ZN A 497 (-2.2A) | 1.41A | 6bp4B-3n71A:5.5 | 6bp4B-3n71A:18.61 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ooi | HISTONE-LYSINEN-METHYLTRANSFERASE,H3 LYSINE-36 AND H4LYSINE-20 SPECIFIC (Homo sapiens) |
PF00856(SET) | 7 | GLY A 102TRP A 103TYR A 146HIS A 170CYH A 219CYH A 221LEU A 230 | SAM A 237 ( 3.7A)NoneSAM A 237 (-4.1A)SAM A 237 (-4.7A) ZN A 232 ( 2.3A) ZN A 232 (-2.3A)SAM A 237 (-4.8A) | 0.76A | 6bp4B-3ooiA:19.5 | 6bp4B-3ooiA:27.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ooi | HISTONE-LYSINEN-METHYLTRANSFERASE,H3 LYSINE-36 AND H4LYSINE-20 SPECIFIC (Homo sapiens) |
PF00856(SET) | 7 | GLY A 102TRP A 103TYR A 146HIS A 170TYR A 207CYH A 219CYH A 221 | SAM A 237 ( 3.7A)NoneSAM A 237 (-4.1A)SAM A 237 (-4.7A)None ZN A 232 ( 2.3A) ZN A 232 (-2.3A) | 0.38A | 6bp4B-3ooiA:19.5 | 6bp4B-3ooiA:27.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ooi | HISTONE-LYSINEN-METHYLTRANSFERASE,H3 LYSINE-36 AND H4LYSINE-20 SPECIFIC (Homo sapiens) |
PF00856(SET) | 6 | GLY A 102TRP A 103TYR A 146HIS A 170TYR A 207CYH A 221 | SAM A 237 ( 3.7A)NoneSAM A 237 (-4.1A)SAM A 237 (-4.7A)None ZN A 232 (-2.3A) | 1.32A | 6bp4B-3ooiA:19.5 | 6bp4B-3ooiA:27.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ooi | HISTONE-LYSINEN-METHYLTRANSFERASE,H3 LYSINE-36 AND H4LYSINE-20 SPECIFIC (Homo sapiens) |
PF00856(SET) | 5 | GLY A 104TYR A 146HIS A 170TYR A 207CYH A 221 | NoneSAM A 237 (-4.1A)SAM A 237 (-4.7A)None ZN A 232 (-2.3A) | 0.87A | 6bp4B-3ooiA:19.5 | 6bp4B-3ooiA:27.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3ooi | HISTONE-LYSINEN-METHYLTRANSFERASE,H3 LYSINE-36 AND H4LYSINE-20 SPECIFIC (Homo sapiens) |
PF00856(SET) | 5 | GLY A 104TYR A 146HIS A 170TYR A 207CYH A 221 | NoneSAM A 237 (-4.1A)SAM A 237 (-4.7A)None ZN A 232 (-2.3A) | 1.44A | 6bp4B-3ooiA:19.5 | 6bp4B-3ooiA:27.57 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ope | PROBABLEHISTONE-LYSINEN-METHYLTRANSFERASEASH1L (Homo sapiens) |
PF00856(SET) | 8 | LYS A2150GLY A2151TRP A2152TYR A2194HIS A2218TYR A2255CYH A2268CYH A2270 | NoneSAM A 7 (-3.4A)NoneSAM A 7 (-3.4A)NoneNone ZN A 1 ( 2.5A) ZN A 1 (-2.7A) | 0.57A | 6bp4B-3opeA:18.7 | 6bp4B-3opeA:30.07 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 3ope | PROBABLEHISTONE-LYSINEN-METHYLTRANSFERASEASH1L (Homo sapiens) |
PF00856(SET) | 7 | LYS A2150GLY A2151TRP A2152TYR A2194HIS A2218TYR A2255CYH A2270 | NoneSAM A 7 (-3.4A)NoneSAM A 7 (-3.4A)NoneNone ZN A 1 (-2.7A) | 1.38A | 6bp4B-3opeA:18.7 | 6bp4B-3opeA:30.07 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3p14 | L-RHAMNOSE ISOMERASE (Bacillushalodurans) |
PF06134(RhaA) | 5 | ILE A 95TYR A 96HIS A 113ARG A 106LEU A 109 | None | 1.21A | 6bp4B-3p14A:undetectable | 6bp4B-3p14A:20.05 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3plw | RECOMBINATIONENHANCEMENT FUNCTIONPROTEIN (Escherichiavirus P1) |
PF16786(RecA_dep_nuc) | 5 | ILE A 114HIS A 133CYH A 96CYH A 99LEU A 129 | None ZN A 188 (-3.2A) ZN A 188 (-2.3A) ZN A 188 (-2.2A)None | 1.27A | 6bp4B-3plwA:undetectable | 6bp4B-3plwA:19.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3thc | BETA-GALACTOSIDASE (Homo sapiens) |
PF01301(Glyco_hydro_35)PF13364(BetaGal_dom4_5) | 5 | GLY A 133ILE A 489TYR A 192TYR A 154LEU A 139 | None | 1.40A | 6bp4B-3thcA:undetectable | 6bp4B-3thcA:19.03 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 3zfx | EPHRIN TYPE-BRECEPTOR 1 (Homo sapiens) |
PF07714(Pkinase_Tyr) | 5 | GLY A 673ILE A 671TYR A 740HIS A 677TYR A 734 | None | 1.40A | 6bp4B-3zfxA:undetectable | 6bp4B-3zfxA:19.57 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4a3s | 6-PHOSPHOFRUCTOKINASE (Bacillussubtilis) |
PF00365(PFK) | 5 | GLY A 268ILE A 137TYR A 106CYH A 119GLY A 101 | None | 1.01A | 6bp4B-4a3sA:undetectable | 6bp4B-4a3sA:19.94 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 4fmu | HISTONE-LYSINEN-METHYLTRANSFERASESETD2 (Homo sapiens) |
PF00856(SET) | 8 | LYS A1560GLY A1561TRP A1562TYR A1605HIS A1629CYH A1678CYH A1680LEU A1689 | None0UM A1804 (-3.5A)None0UM A1804 (-4.2A)None ZN A1803 ( 2.2A) ZN A1803 (-2.2A)0UM A1804 (-4.8A) | 0.61A | 6bp4B-4fmuA:18.2 | 6bp4B-4fmuA:30.97 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4i4i | 6-PHOSPHOFRUCTOKINASE (Geobacillusstearothermophilus) |
PF00365(PFK) | 5 | GLY A 268ILE A 137TYR A 106CYH A 119GLY A 101 | None | 1.05A | 6bp4B-4i4iA:undetectable | 6bp4B-4i4iA:19.88 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4ijj | PUTATIVE C4-TYPEZINC FINGER PROTEIN,DKSA/TRAR FAMILY (Pseudomonasaeruginosa) |
PF01258(zf-dskA_traR) | 5 | ILE A 118TYR A 14ARG A 107LEU A 108GLY A 104 | NoneNoneSO4 A 201 ( 4.8A)NoneNone | 1.41A | 6bp4B-4ijjA:undetectable | 6bp4B-4ijjA:18.24 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4qeo | HISTONE-LYSINEN-METHYLTRANSFERASE,H3 LYSINE-9 SPECIFICSUVH4 (Arabidopsisthaliana) |
PF00856(SET)PF02182(SAD_SRA)PF05033(Pre-SET) | 9 | LYS A 456GLY A 457TRP A 458TYR A 493HIS A 552TYR A 593CYH A 612CYH A 614LEU A 623 | SAH A 801 (-4.7A)SAH A 801 (-3.6A)SAH A 801 (-4.9A)SAH A 801 (-4.0A)NoneNone ZN A 805 ( 2.4A) ZN A 805 ( 2.4A)None | 0.66A | 6bp4B-4qeoA:27.0 | 6bp4B-4qeoA:24.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4r9g | MBP1 (Caldanaerobiuspolysaccharolyticus) |
PF13416(SBP_bac_8) | 5 | GLY A 127ILE A 129TYR A 120LEU A 91GLY A 131 | None | 1.36A | 6bp4B-4r9gA:undetectable | 6bp4B-4r9gA:20.70 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z3n | PUTATIVE DRUG/SODIUMANTIPORTER (Escherichiacoli) |
PF01554(MatE) | 5 | GLY A 80ILE A 126TYR A 155LEU A 137GLY A 130 | OLC A 507 ( 3.8A)NoneNoneNoneNone | 1.31A | 6bp4B-4z3nA:undetectable | 6bp4B-4z3nA:20.08 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z4p | HISTONE-LYSINEN-METHYLTRANSFERASE2D (Homo sapiens) |
PF00856(SET) | 5 | GLY A5408HIS A5475CYH A5525CYH A5527GLY A5538 | SAH A5602 (-3.6A)None ZN A5601 ( 2.2A) ZN A5601 ( 2.2A)SAH A5602 ( 4.2A) | 0.95A | 6bp4B-4z4pA:13.7 | 6bp4B-4z4pA:22.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z4p | HISTONE-LYSINEN-METHYLTRANSFERASE2D (Homo sapiens) |
PF00856(SET) | 6 | GLY A5408TYR A5451HIS A5475TYR A5512CYH A5525CYH A5527 | SAH A5602 (-3.6A)SAH A5602 (-4.5A)NoneNone ZN A5601 ( 2.2A) ZN A5601 ( 2.2A) | 0.47A | 6bp4B-4z4pA:13.7 | 6bp4B-4z4pA:22.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 4z4p | HISTONE-LYSINEN-METHYLTRANSFERASE2D (Homo sapiens) |
PF00856(SET) | 5 | GLY A5410TYR A5451HIS A5475TYR A5512CYH A5527 | NoneSAH A5602 (-4.5A)NoneNone ZN A5601 ( 2.2A) | 0.89A | 6bp4B-4z4pA:13.7 | 6bp4B-4z4pA:22.95 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5d3i | STAPHYLOCOCCALSUPERANTIGEN-LIKEPROTEIN 3 (Staphylococcusaureus) |
PF02876(Stap_Strp_tox_C)PF09199(SSL_OB) | 5 | GLY B 284TYR B 138HIS B 275ARG B 268LEU B 271 | None | 1.38A | 6bp4B-5d3iB:undetectable | 6bp4B-5d3iB:22.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5dae | AAEL006007-PA (Aedes aegypti) |
PF00050(Kazal_1) | 5 | LYS A 20GLY A 16ILE A 32LEU A 36GLY A 37 | None | 1.37A | 6bp4B-5daeA:undetectable | 6bp4B-5daeA:10.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5e9q | GENOME POLYPROTEIN (Dengue virus) |
PF01728(FtsJ) | 5 | GLY A 58TRP A 87HIS A 53ARG A 84LEU A 45 | SAM A 301 (-3.2A)SAM A 301 (-3.6A)None5KY A 302 (-3.7A)None | 1.39A | 6bp4B-5e9qA:undetectable | 6bp4B-5e9qA:22.22 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ey9 | LONG-CHAIN-FATTY-ACID--AMP LIGASE FADD32 (Mycobacteriummarinum) |
PF00501(AMP-binding) | 5 | TRP A 420ILE A 483TYR A 469ARG A 482GLY A 481 | NoneNoneNone5SV A 701 (-3.9A)None | 1.47A | 6bp4B-5ey9A:undetectable | 6bp4B-5ey9A:18.76 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f59 | HISTONE-LYSINEN-METHYLTRANSFERASE2C (Homo sapiens) |
PF00856(SET) | 6 | GLY A4782TYR A4825HIS A4849TYR A4886CYH A4899CYH A4901 | SAH A5002 (-3.5A)SAH A5002 (-4.5A)SAH A5002 (-4.6A)None ZN A5001 ( 2.0A) ZN A5001 (-2.3A) | 0.59A | 6bp4B-5f59A:13.3 | 6bp4B-5f59A:22.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f59 | HISTONE-LYSINEN-METHYLTRANSFERASE2C (Homo sapiens) |
PF00856(SET) | 5 | GLY A4784TYR A4825HIS A4849TYR A4886CYH A4901 | NoneSAH A5002 (-4.5A)SAH A5002 (-4.6A)None ZN A5001 (-2.3A) | 1.47A | 6bp4B-5f59A:13.3 | 6bp4B-5f59A:22.56 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f6l | HISTONE-LYSINEN-METHYLTRANSFERASE2A (Homo sapiens) |
PF00856(SET) | 6 | GLY A3840HIS A3907TYR A3944CYH A3957CYH A3959LEU A3968 | SAH A4001 (-3.4A)SAH A4001 (-4.9A)SAH A4001 (-4.9A) ZN A4002 ( 2.3A) ZN A4002 (-2.3A)None | 0.71A | 6bp4B-5f6lA:12.7 | 6bp4B-5f6lA:26.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f6l | HISTONE-LYSINEN-METHYLTRANSFERASE2A (Homo sapiens) |
PF00856(SET) | 5 | GLY A3842TYR A3883HIS A3907TYR A3944CYH A3959 | NoneNoneSAH A4001 (-4.9A)SAH A4001 (-4.9A) ZN A4002 (-2.3A) | 1.49A | 6bp4B-5f6lA:12.7 | 6bp4B-5f6lA:26.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5f6l | HISTONE-LYSINEN-METHYLTRANSFERASE2A (Homo sapiens) |
PF00856(SET) | 6 | TYR A3883HIS A3907TYR A3944CYH A3957CYH A3959LEU A3968 | NoneSAH A4001 (-4.9A)SAH A4001 (-4.9A) ZN A4002 ( 2.3A) ZN A4002 (-2.3A)None | 0.62A | 6bp4B-5f6lA:12.7 | 6bp4B-5f6lA:26.33 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5hl4 | RING-HYDROXYLATINGDIOXYGENASE (Sinorhizobiummeliloti) |
PF00355(Rieske)PF00848(Ring_hydroxyl_A) | 5 | GLY A 90TYR A 113CYH A 94LEU A 136GLY A 135 | None | 1.15A | 6bp4B-5hl4A:undetectable | 6bp4B-5hl4A:20.79 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5i4d | SUPERANTIGEN-LIKEPROTEIN (Staphylococcusaureus) |
PF02876(Stap_Strp_tox_C)PF09199(SSL_OB) | 5 | GLY A 314TYR A 168HIS A 305ARG A 298LEU A 301 | None | 1.41A | 6bp4B-5i4dA:undetectable | 6bp4B-5i4dA:20.64 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5ikm | NS5 METHYLTRANSFERASE (Dengue virus) |
PF01728(FtsJ) | 5 | GLY A 58TRP A 87HIS A 53ARG A 84LEU A 45 | SAM A 311 (-3.3A)SAM A 311 (-3.5A)NoneSO4 A 303 (-3.2A)None | 1.44A | 6bp4B-5ikmA:undetectable | 6bp4B-5ikmA:21.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5kjm | N-LYSINEMETHYLTRANSFERASESMYD2 (Homo sapiens) |
PF00856(SET)PF01753(zf-MYND) | 5 | GLY A 16HIS A 207TYR A 240CYH A 262CYH A 264 | NoneNone6TM A 502 ( 3.6A) ZN A 505 (-2.3A) ZN A 505 (-2.4A) | 1.04A | 6bp4B-5kjmA:5.6 | 6bp4B-5kjmA:19.91 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lsu | HISTONE-LYSINEN-METHYLTRANSFERASENSD2 (Homo sapiens) |
PF00856(SET) | 8 | GLY A1074TRP A1075TYR A1118HIS A1142TYR A1179CYH A1191CYH A1193LEU A1202 | SAM A1304 ( 3.2A)NoneSAM A1304 (-3.8A)SAM A1304 (-4.6A)SAM A1304 (-4.1A) ZN A1301 ( 2.3A) ZN A1301 (-2.3A)SAM A1304 ( 4.7A) | 0.61A | 6bp4B-5lsuA:20.2 | 6bp4B-5lsuA:29.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lsu | HISTONE-LYSINEN-METHYLTRANSFERASENSD2 (Homo sapiens) |
PF00856(SET) | 6 | GLY A1074TRP A1075TYR A1118HIS A1142TYR A1179CYH A1193 | SAM A1304 ( 3.2A)NoneSAM A1304 (-3.8A)SAM A1304 (-4.6A)SAM A1304 (-4.1A) ZN A1301 (-2.3A) | 1.35A | 6bp4B-5lsuA:20.2 | 6bp4B-5lsuA:29.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lsu | HISTONE-LYSINEN-METHYLTRANSFERASENSD2 (Homo sapiens) |
PF00856(SET) | 5 | GLY A1076TYR A1118HIS A1142TYR A1179CYH A1193 | SAM A1304 ( 4.6A)SAM A1304 (-3.8A)SAM A1304 (-4.6A)SAM A1304 (-4.1A) ZN A1301 (-2.3A) | 0.90A | 6bp4B-5lsuA:20.2 | 6bp4B-5lsuA:29.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5lsu | HISTONE-LYSINEN-METHYLTRANSFERASENSD2 (Homo sapiens) |
PF00856(SET) | 5 | GLY A1076TYR A1118HIS A1142TYR A1179CYH A1193 | SAM A1304 ( 4.6A)SAM A1304 (-3.8A)SAM A1304 (-4.6A)SAM A1304 (-4.1A) ZN A1301 (-2.3A) | 1.44A | 6bp4B-5lsuA:20.2 | 6bp4B-5lsuA:29.04 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n2g | DNA POLYMERASE (Vaccinia virus) |
no annotation | 5 | ILE A 695TYR A 550TYR A 554ARG A 692GLY A 691 | None | 1.43A | 6bp4B-5n2gA:undetectable | 6bp4B-5n2gA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n4l | CERULOPLASMIN (Rattusnorvegicus) |
no annotation | 5 | GLY A 600TRP A 363HIS A 679CYH A 674GLY A 682 | None | 1.31A | 6bp4B-5n4lA:undetectable | 6bp4B-5n4lA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5n4l | CERULOPLASMIN (Rattusnorvegicus) |
no annotation | 5 | GLY A 600TRP A 363HIS A 679CYH A 674GLY A 683 | None | 1.43A | 6bp4B-5n4lA:undetectable | 6bp4B-5n4lA:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5oik | TRANSCRIPTIONELONGATION FACTORSPT4 (Homo sapiens) |
PF06093(Spt4) | 5 | TYR Y 85CYH Y 33CYH Y 36LEU Y 21GLY Y 83 | None ZN Y 201 (-2.3A) ZN Y 201 (-2.3A)NoneNone | 1.30A | 6bp4B-5oikY:undetectable | 6bp4B-5oikY:16.09 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5teg | N-LYSINEMETHYLTRANSFERASEKMT5A (Homo sapiens) |
PF00856(SET) | 5 | LYS A 226GLY A 227TYR A 271HIS A 299TYR A 336 | SAM A 401 (-4.6A)SAM A 401 ( 4.0A)SAM A 401 (-4.1A)NoneSAM A 401 (-4.8A) | 0.47A | 6bp4B-5tegA:12.0 | 6bp4B-5tegA:20.72 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tmh | POLYPROTEIN (Zika virus) |
PF00972(Flavi_NS5)PF01728(FtsJ) | 5 | GLY A 58TRP A 87HIS A 53ARG A 84LEU A 44 | SAH A1001 (-3.2A)SAH A1001 (-3.5A)NoneNoneNone | 1.43A | 6bp4B-5tmhA:undetectable | 6bp4B-5tmhA:16.98 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5tr3 | DIHYDROLIPOYLDEHYDROGENASE (Pseudomonasputida) |
PF02852(Pyr_redox_dim)PF07992(Pyr_redox_2) | 5 | GLY A 193ILE A 274CYH A 54LEU A 175GLY A 173 | NoneNoneFAD A 501 (-3.2A)NoneNone | 1.49A | 6bp4B-5tr3A:undetectable | 6bp4B-5tr3A:22.15 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5tuy | HISTONE-LYSINEN-METHYLTRANSFERASEEHMT2 (Homo sapiens) |
PF00856(SET)PF05033(Pre-SET) | 5 | GLY A1035TYR A 996CYH A1027CYH A1017GLY A1000 | NoneNone ZN A1501 (-1.9A) ZN A1501 ( 2.1A)None | 1.18A | 6bp4B-5tuyA:27.5 | 6bp4B-5tuyA:35.65 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5tuy | HISTONE-LYSINEN-METHYLTRANSFERASEEHMT2 (Homo sapiens) |
PF00856(SET)PF05033(Pre-SET) | 7 | GLY A1049TRP A1050TYR A1085HIS A1113TYR A1154CYH A1168CYH A1170 | SAM A1505 ( 3.9A)NoneSAM A1505 (-4.0A)SAM A1505 (-4.7A)SAM A1505 (-4.9A) ZN A1504 (-2.2A) ZN A1504 (-2.2A) | 0.41A | 6bp4B-5tuyA:27.5 | 6bp4B-5tuyA:35.65 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5tuy | HISTONE-LYSINEN-METHYLTRANSFERASEEHMT2 (Homo sapiens) |
PF00856(SET)PF05033(Pre-SET) | 6 | GLY A1049TRP A1050TYR A1085HIS A1113TYR A1154CYH A1170 | SAM A1505 ( 3.9A)NoneSAM A1505 (-4.0A)SAM A1505 (-4.7A)SAM A1505 (-4.9A) ZN A1504 (-2.2A) | 1.37A | 6bp4B-5tuyA:27.5 | 6bp4B-5tuyA:35.65 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5tuy | HISTONE-LYSINEN-METHYLTRANSFERASEEHMT2 (Homo sapiens) |
PF00856(SET)PF05033(Pre-SET) | 5 | GLY A1051TYR A1085HIS A1113TYR A1154CYH A1170 | NoneSAM A1505 (-4.0A)SAM A1505 (-4.7A)SAM A1505 (-4.9A) ZN A1504 (-2.2A) | 1.45A | 6bp4B-5tuyA:27.5 | 6bp4B-5tuyA:35.65 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5uos | METHYLMALONICACIDURIA ANDHOMOCYSTINURIA TYPEC PROTEIN (Homo sapiens) |
PF16690(MMACHC) | 5 | GLY A 162ILE A 101HIS A 86CYH A 82GLY A 88 | None171 A 304 (-4.4A)NoneNone171 A 304 ( 4.0A) | 0.85A | 6bp4B-5uosA:undetectable | 6bp4B-5uosA:21.27 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5vsd | HISTONE-LYSINEN-METHYLTRANSFERASEEHMT1 (Homo sapiens) |
PF00856(SET)PF05033(Pre-SET) | 7 | GLY A1137TRP A1138TYR A1173HIS A1201TYR A1242CYH A1256CYH A1258 | SAM A3001 (-3.6A)NoneSAM A3001 (-4.0A)SAM A3001 (-4.6A)SAM A3001 (-4.8A) ZN A3005 ( 2.4A) ZN A3005 (-2.3A) | 0.50A | 6bp4B-5vsdA:26.8 | 6bp4B-5vsdA:35.92 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5vsd | HISTONE-LYSINEN-METHYLTRANSFERASEEHMT1 (Homo sapiens) |
PF00856(SET)PF05033(Pre-SET) | 6 | GLY A1137TRP A1138TYR A1173HIS A1201TYR A1242CYH A1258 | SAM A3001 (-3.6A)NoneSAM A3001 (-4.0A)SAM A3001 (-4.6A)SAM A3001 (-4.8A) ZN A3005 (-2.3A) | 1.31A | 6bp4B-5vsdA:26.8 | 6bp4B-5vsdA:35.92 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5vsd | HISTONE-LYSINEN-METHYLTRANSFERASEEHMT1 (Homo sapiens) |
PF00856(SET)PF05033(Pre-SET) | 5 | GLY A1139TYR A1173HIS A1201TYR A1242CYH A1258 | NoneSAM A3001 (-4.0A)SAM A3001 (-4.6A)SAM A3001 (-4.8A) ZN A3005 (-2.3A) | 0.97A | 6bp4B-5vsdA:26.8 | 6bp4B-5vsdA:35.92 | ||
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target. | 5vsd | HISTONE-LYSINEN-METHYLTRANSFERASEEHMT1 (Homo sapiens) |
PF00856(SET)PF05033(Pre-SET) | 5 | GLY A1139TYR A1173HIS A1201TYR A1242CYH A1258 | NoneSAM A3001 (-4.0A)SAM A3001 (-4.6A)SAM A3001 (-4.8A) ZN A3005 (-2.3A) | 1.45A | 6bp4B-5vsdA:26.8 | 6bp4B-5vsdA:35.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5vvr | DNA REPAIR ANDRECOMBINATIONPROTEIN RAD26 (Saccharomycescerevisiae) |
no annotation | 5 | GLY M 736ILE M 708ARG M 711LEU M 714GLY M 710 | None | 1.39A | 6bp4B-5vvrM:undetectable | 6bp4B-5vvrM:13.92 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5wuj | FLAGELLAR M-RINGPROTEINFLAGELLAR MOTORSWITCH PROTEIN FLIG (Helicobacterpylori;Helicobacterpylori) |
no annotationno annotation | 5 | GLY B 30ILE B 27TYR A 530LEU B 68GLY B 64 | NoneGOL B 201 (-4.5A)NoneNoneNone | 1.24A | 6bp4B-5wujB:undetectable | 6bp4B-5wujB:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 5zcs | TARGET OF RAPAMYCINCOMPLEX SUBUNIT LST8 (Homo sapiens) |
no annotation | 5 | ILE C 304CYH C 244CYH C 238LEU C 258GLY C 302 | None | 1.45A | 6bp4B-5zcsC:undetectable | 6bp4B-5zcsC:undetectable | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cen | HISTONE-LYSINEN-METHYLTRANSFERASENSD3 (Homo sapiens) |
no annotation | 8 | GLY A1156TRP A1157TYR A1200HIS A1224TYR A1261CYH A1273CYH A1275LEU A1284 | SAM A1301 (-3.6A)NoneSAM A1301 (-3.9A)NoneSAM A1301 (-4.9A) ZN A1304 ( 2.3A) ZN A1304 (-2.3A)SAM A1301 (-4.6A) | 0.37A | 6bp4B-6cenA:19.6 | 6bp4B-6cenA:27.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cen | HISTONE-LYSINEN-METHYLTRANSFERASENSD3 (Homo sapiens) |
no annotation | 6 | GLY A1156TRP A1157TYR A1200HIS A1224TYR A1261CYH A1275 | SAM A1301 (-3.6A)NoneSAM A1301 (-3.9A)NoneSAM A1301 (-4.9A) ZN A1304 (-2.3A) | 1.46A | 6bp4B-6cenA:19.6 | 6bp4B-6cenA:27.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cen | HISTONE-LYSINEN-METHYLTRANSFERASENSD3 (Homo sapiens) |
no annotation | 6 | GLY A1158TYR A1200HIS A1224TYR A1261CYH A1273CYH A1275 | NoneSAM A1301 (-3.9A)NoneSAM A1301 (-4.9A) ZN A1304 ( 2.3A) ZN A1304 (-2.3A) | 1.39A | 6bp4B-6cenA:19.6 | 6bp4B-6cenA:27.42 | ||
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site. | 6cen | HISTONE-LYSINEN-METHYLTRANSFERASENSD3 (Homo sapiens) |
no annotation | 5 | GLY A1158TYR A1200HIS A1224TYR A1261CYH A1275 | NoneSAM A1301 (-3.9A)NoneSAM A1301 (-4.9A) ZN A1304 (-2.3A) | 0.94A | 6bp4B-6cenA:19.6 | 6bp4B-6cenA:27.42 |