SIMILAR PATTERNS OF AMINO ACIDS FOR 6BM5_A_SAMA1301

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k7y METHIONINE SYNTHASE

(Escherichia
coli) 		PF02310
(B12-binding)
PF02607
(B12-binding_2)
PF02965
(Met_synt_B12) 		11 ASP A 946
PRO A 949
ARG A1094
GLU A1097
ARG A1134
PRO A1135
ALA A1136
TYR A1139
PRO A1140
ALA A1141
TYR A1189
 None
None
B12  A1248 ( 4.9A)
B12  A1248 ( 4.8A)
None
None
B12  A1248 (-3.6A)
B12  A1248 ( 3.8A)
B12  A1248 ( 4.6A)
None
None
 0.84A 6bm5A-1k7yA:
48.9		 6bm5A-1k7yA:
99.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1k7y METHIONINE SYNTHASE

(Escherichia
coli) 		PF02310
(B12-binding)
PF02607
(B12-binding_2)
PF02965
(Met_synt_B12) 		6 ASP A 946
PRO A 949
ARG A1094
TYR A1139
PRO A1140
ALA A1191
 None
None
B12  A1248 ( 4.9A)
B12  A1248 ( 3.8A)
B12  A1248 ( 4.6A)
None
 1.37A 6bm5A-1k7yA:
48.9		 6bm5A-1k7yA:
99.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1msk COBALAMIN-DEPENDENT
METHIONINE SYNTHASE

(Escherichia
coli) 		PF02965
(Met_synt_B12) 		11 ASP A 946
PRO A 949
ARG A1094
GLU A1097
ARG A1134
PRO A1135
ALA A1136
TYR A1139
PRO A1140
ALA A1141
TYR A1189
 SAM  A1301 (-3.5A)
None
SAM  A1301 (-3.4A)
SAM  A1301 (-4.0A)
SAM  A1301 (-3.7A)
SAM  A1301 (-4.5A)
SAM  A1301 (-3.8A)
SAM  A1301 (-3.8A)
SAM  A1301 ( 4.1A)
SAM  A1301 (-3.1A)
SAM  A1301 (-4.1A)
 0.16A 6bm5A-1mskA:
50.7		 6bm5A-1mskA:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s7g NAD-DEPENDENT
DEACETYLASE 2

(Archaeoglobus
fulgidus) 		PF02146
(SIR2) 		5 ARG A 108
ALA A 109
TYR A  83
PRO A  80
ALA A  81
 None
 1.25A 6bm5A-1s7gA:
undetectable		 6bm5A-1s7gA:
22.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xdi RV3303C-LPDA

(Mycobacterium
tuberculosis) 		PF02852
(Pyr_redox_dim)
PF07992
(Pyr_redox_2) 		5 ASP A  46
ARG A 173
ALA A  13
ALA A  18
TYR A  15
 None
None
FAD  A 999 (-3.5A)
None
None
 1.25A 6bm5A-1xdiA:
0.0		 6bm5A-1xdiA:
20.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1yjk PEPTIDYL-GLYCINE
ALPHA-AMIDATING
MONOOXYGENASE

(Rattus
norvegicus) 		PF01082
(Cu2_monooxygen)
PF03712
(Cu2_monoox_C) 		5 PRO A 355
ALA A 273
TYR A 275
PRO A 276
ALA A 238
 None
None
None
None
GOL  A 701 (-3.7A)
 1.46A 6bm5A-1yjkA:
0.0		 6bm5A-1yjkA:
23.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zpu IRON TRANSPORT
MULTICOPPER OXIDASE
FET3

(Saccharomyces
cerevisiae) 		PF00394
(Cu-oxidase)
PF07731
(Cu-oxidase_2)
PF07732
(Cu-oxidase_3) 		5 PRO A 448
ARG A 463
PRO A 464
TYR A 431
PRO A 439
 None
 1.27A 6bm5A-1zpuA:
0.0		 6bm5A-1zpuA:
19.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2c4m GLYCOGEN
PHOSPHORYLASE

(Corynebacterium
callunae) 		PF00343
(Phosphorylase) 		5 ASP A 728
ARG A 569
ALA A 572
ALA A 563
TYR A 567
 None
 1.45A 6bm5A-2c4mA:
0.0		 6bm5A-2c4mA:
18.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkj SERINE
HYDROXYMETHYLTRANSFE
RASE

(Thermus
thermophilus) 		PF00464
(SHMT) 		5 ASP A  68
PRO A  56
ARG A  59
GLU A 261
ALA A 270
 None
 1.47A 6bm5A-2dkjA:
0.0		 6bm5A-2dkjA:
22.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hne L-FUCONATE
DEHYDRATASE

(Xanthomonas
campestris) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ASP A 324
PRO A 186
ALA A 187
TYR A 402
TYR A 185
 None
 1.28A 6bm5A-2hneA:
0.0		 6bm5A-2hneA:
20.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvu MALTOSE BINDING
PROTEIN/NEDD8-ACTIVA
TING ENZYME E1
CATALYTIC SUBUNIT
CHIMERA

(Homo sapiens) 		PF00899
(ThiF)
PF08825
(E2_bind)
PF13416
(SBP_bac_8) 		5 PRO B1134
GLU B1131
PRO B1255
ALA B1164
PRO B1160
 None
 1.40A 6bm5A-2nvuB:
undetectable		 6bm5A-2nvuB:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN

(Porphyromonas
gingivalis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		5 ASP A 178
PRO A 176
ARG A 182
PRO A  82
TYR A 117
 ASP  A 178 ( 0.6A)
PRO  A 176 ( 1.1A)
ARG  A 182 ( 0.6A)
PRO  A  82 ( 1.1A)
TYR  A 117 ( 1.3A)
 1.27A 6bm5A-2nvvA:
undetectable		 6bm5A-2nvvA:
21.19
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2o2k METHIONINE SYNTHASE

(Homo sapiens) 		PF02965
(Met_synt_B12) 		10 ASP A 974
PRO A 977
ARG A1132
GLU A1135
ARG A1172
PRO A1173
ALA A1174
TYR A1177
PRO A1178
TYR A1227
 None
 0.55A 6bm5A-2o2kA:
41.9		 6bm5A-2o2kA:
49.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2rdx MANDELATE
RACEMASE/MUCONATE
LACTONIZING ENZYME,
PUTATIVE

(Roseovarius
nubinhibens) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ASP A  12
ARG A 328
ALA A 300
PRO A 104
ALA A 103
 None
 1.15A 6bm5A-2rdxA:
undetectable		 6bm5A-2rdxA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vgq SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,MITOCHONDRIA
L
ANTIVIRAL-SIGNALING
PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF13416
(SBP_bac_8)
PF16739
(CARD_2) 		5 PRO A 133
GLU A 130
PRO A 254
ALA A 163
PRO A 159
 None
 1.45A 6bm5A-2vgqA:
undetectable		 6bm5A-2vgqA:
23.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vun ENAMIDASE

(Eubacterium
barkeri) 		PF01979
(Amidohydro_1) 		5 PRO A 102
ARG A 107
PRO A 173
ALA A 176
PRO A 215
 None
GOL  A1390 (-4.1A)
None
None
None
 1.41A 6bm5A-2vunA:
undetectable		 6bm5A-2vunA:
22.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2waa XYLAN ESTERASE,
PUTATIVE, AXE2C

(Cellvibrio
japonicus) 		PF13472
(Lipase_GDSL_2) 		5 ASP A  66
PRO A  74
ARG A 164
GLU A 165
ALA A 152
 None
 1.47A 6bm5A-2waaA:
undetectable		 6bm5A-2waaA:
22.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x2i ALPHA-1,4-GLUCAN
LYASE ISOZYME 1

(Gracilariopsis
lemaneiformis) 		PF01055
(Glyco_hydro_31) 		5 ASP A  96
PRO A  95
ARG A 187
PRO A 270
ALA A 268
 None
 1.28A 6bm5A-2x2iA:
undetectable		 6bm5A-2x2iA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xz3 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ENVELOPE
GLYCOPROTEIN

(Escherichia
coli;
Bovine leukemia
virus) 		PF00429
(TLV_coat)
PF13416
(SBP_bac_8) 		5 PRO A 159
GLU A 156
PRO A 280
ALA A 189
PRO A 185
 None
 1.44A 6bm5A-2xz3A:
undetectable		 6bm5A-2xz3A:
23.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a3c MALTOSE-BINDING
PERIPLASMIC PROTEIN,
LINKER,
MITOCHONDRIAL
INTERMEMBRANE SPACE
IMPORT AND ASSEMBLY
PROTEIN 40

(Escherichia
coli;
Saccharomyces
cerevisiae;
synthetic
construct) 		PF06747
(CHCH)
PF13416
(SBP_bac_8) 		5 PRO A 133
GLU A 130
PRO A 254
ALA A 163
PRO A 159
 None
 1.47A 6bm5A-3a3cA:
undetectable		 6bm5A-3a3cA:
23.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3auo DNA POLYMERASE BETA
FAMILY (X FAMILY)

(Thermus
thermophilus) 		PF14520
(HHH_5)
PF14716
(HHH_8)
PF14791
(DNA_pol_B_thumb) 		5 ASP A 529
ARG A 506
PRO A 376
ALA A 377
ALA A 381
 ZN  A 579 ( 4.1A)
ZN  A 579 ( 4.3A)
None
None
None
 1.19A 6bm5A-3auoA:
undetectable		 6bm5A-3auoA:
22.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bdz P450CIN

(Citrobacter
braakii) 		PF00067
(p450) 		5 PRO A 393
GLU A 378
PRO A  23
PRO A  27
ALA A  29
 None
 1.37A 6bm5A-3bdzA:
undetectable		 6bm5A-3bdzA:
24.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3csg MALTOSE-BINDING
PROTEIN MONOBODY YS1
FUSION

(Escherichia
coli) 		PF00041
(fn3)
PF13416
(SBP_bac_8) 		5 PRO A 133
GLU A 130
PRO A 254
ALA A 163
PRO A 159
 None
 1.46A 6bm5A-3csgA:
undetectable		 6bm5A-3csgA:
22.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dm0 MALTOSE-BINDING
PERIPLASMIC PROTEIN
FUSED WITH RACK1

(Escherichia
coli;
Arabidopsis
thaliana) 		PF00400
(WD40)
PF01547
(SBP_bac_1) 		5 PRO A 133
GLU A 130
PRO A 254
ALA A 163
PRO A 159
 None
 1.46A 6bm5A-3dm0A:
undetectable		 6bm5A-3dm0A:
19.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ehs FUSION PROTEIN OF
CRFR1 EXTRACELLULAR
DOMAIN AND MBP

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		5 PRO A-216
GLU A-219
PRO A -95
ALA A-186
PRO A-190
 None
 1.37A 6bm5A-3ehsA:
undetectable		 6bm5A-3ehsA:
23.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ein GLUTATHIONE
S-TRANSFERASE 1-1

(Drosophila
melanogaster) 		PF00043
(GST_C)
PF02798
(GST_N) 		5 ASP A 101
ARG A  67
TYR A 114
PRO A 115
TYR A 113
 None
GSH  A 210 (-3.6A)
None
None
None
 1.42A 6bm5A-3einA:
undetectable		 6bm5A-3einA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f5f MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HEPARAN SULFATE
2-O-SULFOTRANSFERASE
1

(Escherichia
coli;
Gallus gallus) 		PF03567
(Sulfotransfer_2)
PF13416
(SBP_bac_8) 		5 PRO A 133
GLU A 130
PRO A 254
ALA A 163
PRO A 159
 None
 1.40A 6bm5A-3f5fA:
undetectable		 6bm5A-3f5fA:
21.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4z MALTOSE-BINDING
PERIPLASMIC PROTEIN
FUSED WITH ALLERGEN
DERP7

(Escherichia
coli;
Dermatophagoides
pteronyssinus) 		PF13416
(SBP_bac_8)
PF16984
(Grp7_allergen) 		5 PRO A 133
GLU A 130
PRO A 254
ALA A 163
PRO A 159
 None
 1.41A 6bm5A-3h4zA:
undetectable		 6bm5A-3h4zA:
22.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l2j FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PARATHYROID
HORMONE/PARATHYROID
HORMONE-RELATED
PEPTIDE RECEPTOR

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		5 PRO A-211
GLU A-214
PRO A -90
ALA A-181
PRO A-185
 None
 1.45A 6bm5A-3l2jA:
undetectable		 6bm5A-3l2jA:
22.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m7d TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24) 		5 ARG A 308
PRO A 330
TYR A 331
PRO A 364
ALA A 367
 None
 1.45A 6bm5A-3m7dA:
undetectable		 6bm5A-3m7dA:
23.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3mp6 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,LINKER,SAGA-
ASSOCIATED FACTOR 29

(Escherichia
coli;
Saccharomyces
cerevisiae;
unidentified) 		PF07039
(DUF1325)
PF13416
(SBP_bac_8) 		5 PRO A 871
GLU A 868
PRO A 992
ALA A 901
PRO A 897
 None
 1.41A 6bm5A-3mp6A:
undetectable		 6bm5A-3mp6A:
22.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n94 FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND PITUITARY
ADENYLATE CYCLASE 1
RECEPTOR-SHORT

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF13416
(SBP_bac_8) 		5 PRO A-215
GLU A-218
PRO A -94
ALA A-185
PRO A-189
 None
 1.46A 6bm5A-3n94A:
undetectable		 6bm5A-3n94A:
23.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3o3u MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR

(Escherichia
coli;
Homo sapiens) 		PF08205
(C2-set_2)
PF13416
(SBP_bac_8) 		5 PRO N 133
GLU N 130
PRO N 254
ALA N 163
PRO N 159
 None
 1.43A 6bm5A-3o3uN:
undetectable		 6bm5A-3o3uN:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3oai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
MYELIN PROTEIN P0

(Escherichia
coli;
Homo sapiens) 		PF07686
(V-set)
PF13416
(SBP_bac_8) 		5 PRO A 133
GLU A 130
PRO A 254
ALA A 163
PRO A 159
 None
 1.47A 6bm5A-3oaiA:
undetectable		 6bm5A-3oaiA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ob4 MALTOSE ABC
TRANSPORTER
PERIPLASMIC PROTEIN,
ARAH 2

(Escherichia
coli;
Arachis
duranensis) 		PF00234
(Tryp_alpha_amyl)
PF13416
(SBP_bac_8) 		5 PRO A 133
GLU A 130
PRO A 254
ALA A 163
PRO A 159
 None
 1.44A 6bm5A-3ob4A:
undetectable		 6bm5A-3ob4A:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,GREEN
FLUORESCENT PROTEIN

(Escherichia
coli;
Aequorea
victoria) 		PF01353
(GFP)
PF01547
(SBP_bac_1)
PF13416
(SBP_bac_8) 		5 PRO A 133
GLU A 130
PRO A 502
ALA A 163
PRO A 159
 None
 1.45A 6bm5A-3osqA:
undetectable		 6bm5A-3osqA:
20.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3py7 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PAXILLIN
LD1,PROTEIN E6
CHIMERA

(Escherichia
coli;
Homo sapiens;
Deltapapillomavirus
4) 		PF00518
(E6)
PF01547
(SBP_bac_1) 		5 PRO A 134
GLU A 131
PRO A 255
ALA A 164
PRO A 160
 None
 1.35A 6bm5A-3py7A:
undetectable		 6bm5A-3py7A:
22.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sh5 LG3 PEPTIDE

(Homo sapiens) 		PF00054
(Laminin_G_1) 		5 PRO A  31
ARG A 122
PRO A 124
ALA A  84
TYR A  77
 None
 1.23A 6bm5A-3sh5A:
undetectable		 6bm5A-3sh5A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wai MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRANSMEMBRANE
OLIGOSACCHARYL
TRANSFERASE

(Escherichia
coli;
Archaeoglobus
fulgidus) 		PF13416
(SBP_bac_8) 		5 PRO A 133
GLU A 130
PRO A 254
ALA A 163
PRO A 159
 None
 1.44A 6bm5A-3waiA:
undetectable		 6bm5A-3waiA:
19.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wvo CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY

(Thermobifida
fusca) 		PF09481
(CRISPR_Cse1) 		5 GLU A 249
ARG A 232
PRO A 233
ALA A 234
ALA A  60
 None
 1.34A 6bm5A-3wvoA:
undetectable		 6bm5A-3wvoA:
20.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a04 T-BOX TRANSCRIPTION
FACTOR TBX1

(Homo sapiens) 		PF00907
(T-box) 		5 ASP A 121
GLU A 122
ALA A 287
PRO A 290
ALA A 292
 None
 1.46A 6bm5A-4a04A:
undetectable		 6bm5A-4a04A:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4avc LYSINE
ACETYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00027
(cNMP_binding)
PF13302
(Acetyltransf_3) 		5 ARG A 166
ARG A 159
ALA A 140
TYR A 204
ALA A 325
 None
 1.37A 6bm5A-4avcA:
undetectable		 6bm5A-4avcA:
21.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b3n MALTOSE-BINDING
PERIPLASMIC PROTEIN,
TRIPARTITE
MOTIF-CONTAINING
PROTEIN 5

(Escherichia
coli;
Macaca mulatta) 		PF00622
(SPRY)
PF01547
(SBP_bac_1) 		5 PRO A 133
GLU A 130
PRO A 254
ALA A 163
PRO A 159
 None
 1.41A 6bm5A-4b3nA:
undetectable		 6bm5A-4b3nA:
21.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4edq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MYOSIN-BINDI
NG PROTEIN C,
CARDIAC-TYPE
CHIMERIC PROTEIN

(Escherichia
coli;
Mus musculus) 		PF07679
(I-set)
PF13416
(SBP_bac_8) 		5 PRO A 134
GLU A 131
PRO A 255
ALA A 164
PRO A 160
 None
 1.41A 6bm5A-4edqA:
undetectable		 6bm5A-4edqA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4egc MALTOSE-BINDING
PERIPLASMIC PROTEIN,
HOMEOBOX PROTEIN
SIX1 CHIMERA

(Escherichia
coli;
Homo sapiens) 		PF00046
(Homeobox)
PF13416
(SBP_bac_8)
PF16878
(SIX1_SD) 		5 PRO A 133
GLU A 130
PRO A 254
ALA A 163
PRO A 159
 None
 1.42A 6bm5A-4egcA:
undetectable		 6bm5A-4egcA:
22.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4exk MALTOSE-BINDING
PERIPLASMIC PROTEIN,
UNCHARACTERIZED
PROTEIN CHIMERA

(Escherichia
coli;
Salmonella
enterica) 		PF13416
(SBP_bac_8)
PF16583
(ZirS_C) 		5 PRO A 133
GLU A 130
PRO A 254
ALA A 163
PRO A 159
 None
 1.34A 6bm5A-4exkA:
undetectable		 6bm5A-4exkA:
21.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gfj TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		5 ARG A 308
PRO A 330
TYR A 331
PRO A 364
ALA A 367
 None
 1.47A 6bm5A-4gfjA:
undetectable		 6bm5A-4gfjA:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4gis ENOLASE

(Vibrio harveyi) 		PF02746
(MR_MLE_N)
PF13378
(MR_MLE_C) 		5 ASP A  94
PRO A 289
PRO A 314
ALA A 317
PRO A 309
 None
None
None
None
GOL  A 404 (-4.3A)
 1.40A 6bm5A-4gisA:
undetectable		 6bm5A-4gisA:
21.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h1g MALTOSE BINDING
PROTEIN-CAKAR3 MOTOR
DOMAIN FUSION
PROTEIN

(Escherichia
coli;
Candida
albicans) 		PF00225
(Kinesin)
PF13416
(SBP_bac_8) 		5 PRO A-237
GLU A-240
PRO A-116
ALA A-207
PRO A-211
 None
 1.42A 6bm5A-4h1gA:
undetectable		 6bm5A-4h1gA:
19.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ifp MALTOSE-BINDING
PERIPLASMIC
PROTEIN,NACHT, LRR
AND PYD
DOMAINS-CONTAINING
PROTEIN 1

(Escherichia
coli;
Homo sapiens) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		5 PRO A 134
GLU A 131
PRO A 255
ALA A 164
PRO A 160
 None
 1.38A 6bm5A-4ifpA:
undetectable		 6bm5A-4ifpA:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irl MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NOVEL PROTEIN
SIMILAR TO
VERTEBRATE GUANYLATE
BINDING PROTEIN
FAMILY

(Escherichia
coli;
Danio rerio) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		5 PRO A 134
GLU A 131
PRO A 255
ALA A 164
PRO A 160
 None
 1.43A 6bm5A-4irlA:
undetectable		 6bm5A-4irlA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4irx SUGAR ABC
TRANSPORTER,
PERIPLASMIC
SUGAR-BINDING
PROTEIN

(Caulobacter
vibrioides) 		PF13407
(Peripla_BP_4) 		5 ASP A 248
ALA A 161
TYR A 157
PRO A 158
ALA A 159
 None
 0.94A 6bm5A-4irxA:
undetectable		 6bm5A-4irxA:
21.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kv3 CHIMERA FUSION
PROTEIN OF ESX-1
SECRETION SYSTEM
PROTEIN ECCD1 AND
MALTOSE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli;
Mycobacterium
tuberculosis) 		PF08817
(YukD)
PF13416
(SBP_bac_8) 		5 PRO A 134
GLU A 131
PRO A 255
ALA A 164
PRO A 160
 None
 1.41A 6bm5A-4kv3A:
undetectable		 6bm5A-4kv3A:
23.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4my2 MALTOSE-BINDING
PERIPLASMIC PROTEIN,
NORRIN FUSION
PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF00007
(Cys_knot)
PF13416
(SBP_bac_8) 		5 PRO A 135
GLU A 132
PRO A 256
ALA A 165
PRO A 161
 None
 1.44A 6bm5A-4my2A:
undetectable		 6bm5A-4my2A:
22.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n06 CRISPR-ASSOCIATED
ENDONUCLEASE CAS1 1

(Archaeoglobus
fulgidus) 		PF01867
(Cas_Cas1) 		5 PRO A 200
PRO A 233
ALA A 249
ALA A 235
TYR A 234
 None
 1.44A 6bm5A-4n06A:
undetectable		 6bm5A-4n06A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o2x MALTOSE-BINDING
PERIPLASMIC PROTEIN,
ATP-DEPENDENT CLP
PROTEASE ADAPTOR
PROTEIN CLPS
CONTAINING PROTEIN
CHIMERIC CONSTRUCT

(Escherichia
coli;
Plasmodium
falciparum) 		PF02617
(ClpS)
PF13416
(SBP_bac_8) 		5 PRO A 134
GLU A 131
PRO A 255
ALA A 164
PRO A 160
 None
 1.45A 6bm5A-4o2xA:
undetectable		 6bm5A-4o2xA:
21.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ozq CHIMERA OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND KINESIN FAMILY
MEMBER 14 PROTEIN

(Escherichia
coli;
Mus musculus) 		PF00225
(Kinesin)
PF13416
(SBP_bac_8) 		5 PRO A-237
GLU A-240
PRO A-116
ALA A-207
PRO A-211
 None
 1.36A 6bm5A-4ozqA:
undetectable		 6bm5A-4ozqA:
19.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p72 PHENYLALANINE--TRNA
LIGASE BETA SUBUNIT

(Pseudomonas
aeruginosa) 		PF01588
(tRNA_bind)
PF03147
(FDX-ACB)
PF03483
(B3_4)
PF03484
(B5) 		5 ARG A 467
PRO A 185
ALA A  12
PRO A 188
ALA A 187
 None
 1.31A 6bm5A-4p72A:
undetectable		 6bm5A-4p72A:
20.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pe2 MALTOSE ABC
TRANSPORTER
PERIPLASMIC
PROTEIN,PREPILIN-TYP
E N-TERMINAL
CLEAVAGE/METHYLATION
DOMAIN PROTEIN

(Escherichia
coli;
Clostridioides
difficile) 		PF13416
(SBP_bac_8) 		5 PRO A 133
GLU A 130
PRO A 254
ALA A 163
PRO A 159
 None
 1.41A 6bm5A-4pe2A:
undetectable		 6bm5A-4pe2A:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qsz MALTOSE-BINDING
PERIPLASMIC PROTEIN,
JMJC
DOMAIN-CONTAINING
PROTEIN 7 CHIMERA

(Escherichia
coli;
Mus musculus) 		PF13416
(SBP_bac_8)
PF13621
(Cupin_8) 		5 PRO A-238
GLU A-241
PRO A-117
ALA A-208
PRO A-212
 None
 1.47A 6bm5A-4qszA:
undetectable		 6bm5A-4qszA:
20.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qvh MALTOSE-BINDING
PERIPLASMIC PROTEIN,
4'-PHOSPHOPANTETHEIN
YL TRANSFERASE
CHIMERA

(Escherichia
coli;
Mycobacterium
tuberculosis) 		PF01648
(ACPS)
PF13416
(SBP_bac_8) 		5 PRO A 134
GLU A 131
PRO A 255
ALA A 164
PRO A 160
 None
 1.44A 6bm5A-4qvhA:
undetectable		 6bm5A-4qvhA:
20.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rwf MALTOSE TRANSPORTER
SUBUNIT, RECEPTOR
ACTIVITY-MODIFYING
PROTEIN 2,
CALCITONIN
GENE-RELATED PEPTIDE
TYPE 1 RECEPTOR
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF02793
(HRM)
PF04901
(RAMP)
PF13416
(SBP_bac_8) 		5 PRO A 135
GLU A 132
PRO A 256
ALA A 165
PRO A 161
 None
 1.41A 6bm5A-4rwfA:
undetectable		 6bm5A-4rwfA:
22.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4tsm MALTOSE-BINDING
PROTEIN, PILIN
CHIMERA

(Escherichia
coli;
Clostridioides
difficile) 		PF13416
(SBP_bac_8) 		5 PRO A 133
GLU A 130
PRO A 254
ALA A 163
PRO A 159
 None
 1.44A 6bm5A-4tsmA:
undetectable		 6bm5A-4tsmA:
23.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4u33 ALPHA-1,4-GLUCAN:MAL
TOSE-1-PHOSPHATE
MALTOSYLTRANSFERASE

(Mycobacterium
tuberculosis) 		PF00128
(Alpha-amylase)
PF11896
(DUF3416) 		5 PRO A 495
PRO A 590
ALA A 591
PRO A 616
ALA A 617
 None
 1.19A 6bm5A-4u33A:
undetectable		 6bm5A-4u33A:
18.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4whb PHENYLUREA HYDROLASE
B

(Mycolicibacterium
brisbanense) 		no annotation 5 ASP E 211
ALA E 319
PRO E 324
ALA E 326
TYR E 276
 None
 1.40A 6bm5A-4whbE:
undetectable		 6bm5A-4whbE:
22.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wxb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Streptococcus
thermophilus) 		PF00464
(SHMT) 		5 ASP A  66
PRO A  54
ARG A  57
GLU A 259
ALA A 268
 None
 1.42A 6bm5A-4wxbA:
undetectable		 6bm5A-4wxbA:
24.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xa2 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MBP-PILA: C

(Acinetobacter
baumannii;
Escherichia
coli) 		PF00114
(Pilin)
PF13416
(SBP_bac_8) 		5 PRO A 133
GLU A 130
PRO A 254
ALA A 163
PRO A 159
 None
 1.47A 6bm5A-4xa2A:
undetectable		 6bm5A-4xa2A:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xai MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TAILLESS
ORTHOLOG

(Escherichia
coli;
Tribolium
castaneum) 		PF00104
(Hormone_recep)
PF13416
(SBP_bac_8) 		5 PRO A 135
GLU A 132
PRO A 256
ALA A 165
PRO A 161
 None
 1.47A 6bm5A-4xaiA:
undetectable		 6bm5A-4xaiA:
21.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xax DNA-DIRECTED RNA
POLYMERASE SUBUNIT
BETA DOMAIN 1
CARD

(Thermus
aquaticus;
Thermus
thermophilus) 		PF04563
(RNA_pol_Rpb2_1)
PF02559
(CarD_CdnL_TRCF) 		5 ASP A 111
PRO A 369
GLU A 110
ALA B  24
PRO B  50
 None
 1.29A 6bm5A-4xaxA:
undetectable		 6bm5A-4xaxA:
22.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xel INORGANIC
PYROPHOSPHATASE

(Pseudomonas
aeruginosa) 		PF00719
(Pyrophosphatase) 		5 ASP A  68
PRO A  23
TYR A  52
PRO A  53
ALA A  24
 None
 1.46A 6bm5A-4xelA:
undetectable		 6bm5A-4xelA:
19.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4z43 FLAVIN-DEPENDENT
TRYPTOPHAN
HALOGENASE PRNA

(Pseudomonas
fluorescens) 		PF04820
(Trp_halogenase) 		5 ASP A 403
PRO A  91
ALA A 298
TYR A 286
ALA A 245
 None
None
None
None
FAD  A 601 ( 3.7A)
 1.46A 6bm5A-4z43A:
undetectable		 6bm5A-4z43A:
20.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c7r FUSION PROTEIN OF
MALTOSE-BINDING
PERIPLASMIC PROTEIN
AND TYPE-3
ICE-STRUCTURING
PROTEIN HPLC 12

(Escherichia
coli;
Zoarces
americanus) 		PF01547
(SBP_bac_1) 		5 PRO A 133
GLU A 130
PRO A 254
ALA A 163
PRO A 159
 None
 1.38A 6bm5A-5c7rA:
undetectable		 6bm5A-5c7rA:
23.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cfv MALTOSE-BINDING
PERIPLASMIC
PROTEIN,MALTOSE-BIND
ING PERIPLASMIC
PROTEIN,PILA FUSION
PROTEIN

(Escherichia
coli;
Acinetobacter
nosocomialis) 		PF00114
(Pilin)
PF01547
(SBP_bac_1) 		5 PRO A 133
GLU A 130
PRO A 254
ALA A 163
PRO A 159
 None
 1.43A 6bm5A-5cfvA:
undetectable		 6bm5A-5cfvA:
22.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dfm MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TELOMERASE-A
SSOCIATED PROTEIN 19

(Escherichia
coli;
Tetrahymena
thermophila) 		PF13416
(SBP_bac_8) 		5 PRO A 133
GLU A 130
PRO A 254
ALA A 163
PRO A 159
 None
 1.39A 6bm5A-5dfmA:
undetectable		 6bm5A-5dfmA:
21.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gpq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,APOPTOSIS-AS
SOCIATED SPECK-LIKE
PROTEIN CONTAINING A
CARD

(Escherichia
coli;
Danio rerio) 		PF00619
(CARD)
PF13416
(SBP_bac_8) 		5 PRO A 134
GLU A 131
PRO A 255
ALA A 164
PRO A 160
 None
 1.43A 6bm5A-5gpqA:
undetectable		 6bm5A-5gpqA:
22.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5h7n NLRP12-PYD WITH MBP
TAG

(Homo sapiens) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		5 PRO A 134
GLU A 131
PRO A 255
ALA A 164
PRO A 160
 None
 1.46A 6bm5A-5h7nA:
undetectable		 6bm5A-5h7nA:
22.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hm5 TOPOISOMERASE V

(Methanopyrus
kandleri) 		PF13412
(HTH_24)
PF14520
(HHH_5) 		5 ARG A 308
PRO A 330
TYR A 331
PRO A 364
ALA A 367
 None
 1.38A 6bm5A-5hm5A:
undetectable		 6bm5A-5hm5A:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hz7 COMP

(Neisseria
meningitidis) 		PF13416
(SBP_bac_8)
PF16732
(ComP_DUS) 		5 PRO A 134
GLU A 131
PRO A 255
ALA A 164
PRO A 160
 None
 1.41A 6bm5A-5hz7A:
undetectable		 6bm5A-5hz7A:
23.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ii5 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,VITELLINE
ENVELOPE SPERM LYSIN
RECEPTOR

(Escherichia
coli;
Haliotis
rufescens) 		PF11386
(VERL)
PF13416
(SBP_bac_8) 		5 PRO A3800
GLU A3797
PRO A3921
ALA A3830
PRO A3826
 None
 1.41A 6bm5A-5ii5A:
undetectable		 6bm5A-5ii5A:
21.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jj4 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,SINGLE-STRAN
DED DNA CYTOSINE
DEAMINASE

(Escherichia
coli;
Homo sapiens) 		no annotation 5 PRO C 133
GLU C 130
PRO C 254
ALA C 163
PRO C 159
 None
 1.40A 6bm5A-5jj4C:
undetectable		 6bm5A-5jj4C:
21.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jon MALTOSE-BINDING
PERIPLASMIC
PROTEIN,POTASSIUM/SO
DIUM
HYPERPOLARIZATION-AC
TIVATED CYCLIC
NUCLEOTIDE-GATED
CHANNEL 2

(Escherichia
coli;
Mus musculus) 		PF00027
(cNMP_binding)
PF13416
(SBP_bac_8) 		5 PRO A-236
GLU A-239
PRO A-115
ALA A-206
PRO A-210
 None
 1.45A 6bm5A-5jonA:
undetectable		 6bm5A-5jonA:
21.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5k94 MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PROTEIN
TRANSLOCASE SUBUNIT
SECA,MALTOSE-BINDING
PERIPLASMIC PROTEIN

(Escherichia
coli) 		PF01043
(SecA_PP_bind)
PF01547
(SBP_bac_1)
PF13416
(SBP_bac_8) 		5 PRO A 133
GLU A 130
PRO A1254
ALA A 163
PRO A 159
 None
 1.43A 6bm5A-5k94A:
undetectable		 6bm5A-5k94A:
22.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5kei 2,3-DIHYDROXYBENZOAT
E-AMP LIGASE

(Mycolicibacterium
smegmatis) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		5 PRO A 198
PRO A 207
ALA A 208
PRO A 204
ALA A 205
 None
 1.22A 6bm5A-5keiA:
undetectable		 6bm5A-5keiA:
23.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lrb ALPHA-1,4 GLUCAN
PHOSPHORYLASE

(Hordeum vulgare) 		PF00343
(Phosphorylase) 		5 ASP A 275
PRO A 200
ALA A 129
ALA A 126
TYR A 121
 None
 1.40A 6bm5A-5lrbA:
undetectable		 6bm5A-5lrbA:
16.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5osq MALTOSE-BINDING
PERIPLASMIC
PROTEIN,ZONA
PELLUCIDA
SPERM-BINDING
PROTEIN 3

(Escherichia
coli;
Mus musculus) 		PF00100
(Zona_pellucida)
PF13416
(SBP_bac_8) 		5 PRO A 134
GLU A 131
PRO A 255
ALA A 164
PRO A 160
 None
 1.36A 6bm5A-5osqA:
undetectable		 6bm5A-5osqA:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oy9 GLYCOPROTEIN G

(Indiana
vesiculovirus) 		no annotation 5 ASP A 334
PRO A 307
ALA A 306
PRO A 370
ALA A 315
 None
 1.42A 6bm5A-5oy9A:
undetectable		 6bm5A-5oy9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t03 MALTOSE BINDING
PROTEIN - HEPARAN
SULFATE
6-O-SULFOTRANSFERASE
ISOFORM 3 FUSION
PROTEIN

(Escherichia
coli;
Danio rerio) 		PF03567
(Sulfotransfer_2)
PF13416
(SBP_bac_8) 		5 PRO A 133
GLU A 130
PRO A 254
ALA A 163
PRO A 159
 None
 1.45A 6bm5A-5t03A:
undetectable		 6bm5A-5t03A:
19.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tj2 SUGAR ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN,GASDERMIN-B
FUSION PROTEIN

(Escherichia
coli;
Homo sapiens) 		PF04598
(Gasdermin)
PF13416
(SBP_bac_8) 		5 PRO A 133
GLU A 130
PRO A 254
ALA A 163
PRO A 159
 None
 1.44A 6bm5A-5tj2A:
undetectable		 6bm5A-5tj2A:
22.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tky PUTATIVE
UNCHARACTERIZED
PROTEIN

(Chaetomium
thermophilum) 		PF00012
(HSP70) 		5 PRO A  84
PRO A 403
PRO A 150
ALA A 151
TYR A 152
 None
 1.31A 6bm5A-5tkyA:
undetectable		 6bm5A-5tkyA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ttd MALTOSE-BINDING
PERIPLASMIC
PROTEIN,PILIN
ISOPEPTIDE LINKAGE
DOMAIN PROTEIN

(Escherichia
coli;
Streptococcus
pyogenes) 		PF12892
(FctA)
PF13416
(SBP_bac_8) 		5 PRO A 139
GLU A 136
PRO A 260
ALA A 169
PRO A 165
 None
 1.46A 6bm5A-5ttdA:
undetectable		 6bm5A-5ttdA:
22.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5u89 AMINO ACID
ADENYLATION DOMAIN
PROTEIN

(Geobacillus sp.
Y4.1MC1) 		PF00501
(AMP-binding)
PF00550
(PP-binding)
PF00668
(Condensation)
PF13193
(AMP-binding_C) 		5 PRO A 605
ALA A 606
TYR A 534
ALA A 532
TYR A 509
 None
 1.33A 6bm5A-5u89A:
undetectable		 6bm5A-5u89A:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ux5 BIFUNCTIONAL PROTEIN
PROLINE UTILIZATION
A (PUTA)

(Corynebacterium
freiburgense) 		PF00171
(Aldedh)
PF01619
(Pro_dh) 		5 PRO A 489
GLU A 543
PRO A 591
ALA A 618
ALA A 589
 None
None
None
NAD  A2002 (-3.9A)
NAD  A2002 ( 3.9A)
 1.37A 6bm5A-5ux5A:
undetectable		 6bm5A-5ux5A:
16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vaw MALTOSE-BINDING
PERIPLASMIC
PROTEIN,TYPE IV
PILIN PILA

(Acinetobacter
baumannii;
Escherichia
coli) 		no annotation 5 PRO A 133
GLU A 130
PRO A 254
ALA A 163
PRO A 159
 None
 1.45A 6bm5A-5vawA:
undetectable		 6bm5A-5vawA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wq6 MBP TAGGED HMNDA-PYD

(Homo sapiens) 		PF02758
(PYRIN)
PF13416
(SBP_bac_8) 		5 PRO A 134
GLU A 131
PRO A 255
ALA A 164
PRO A 160
 None
 1.41A 6bm5A-5wq6A:
undetectable		 6bm5A-5wq6A:
22.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5z0r EXTRACELLULAR
SOLUTE-BINDING
PROTEIN FAMILY
1,VIRAL GENOME
PROTEIN

(Escherichia
coli) 		no annotation 5 PRO A 134
GLU A 131
PRO A 255
ALA A 164
PRO A 160
 None
 1.32A 6bm5A-5z0rA:
undetectable		 6bm5A-5z0rA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5zwp GLUTATHIONE
S-TRANSFERASE 1

(Musca domestica) 		no annotation 5 ASP A 100
ARG A  66
TYR A 113
PRO A 114
TYR A 112
 None
GSH  A 301 (-3.4A)
FMT  A 302 (-4.4A)
None
None
 1.45A 6bm5A-5zwpA:
undetectable		 6bm5A-5zwpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6apx MALTOSE-BINDING
PERIPLASMIC
PROTEIN,DUAL
SPECIFICITY PROTEIN
PHOSPHATASE 1

(Escherichia
coli;
Homo sapiens) 		no annotation 5 PRO A 133
GLU A 130
PRO A 254
ALA A 163
PRO A 159
 None
 1.40A 6bm5A-6apxA:
undetectable		 6bm5A-6apxA:
22.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 CRISPR-ASSOCIATED
PROTEIN, CSE1 FAMILY

(Thermobifida
fusca) 		no annotation 5 PRO A 352
PRO A  63
ALA A  65
ALA A 187
TYR A 191
 None
 1.39A 6bm5A-6c66A:
undetectable		 6bm5A-6c66A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c66 CRISPR-ASSOCIATED
PROTEIN, CSE4 FAMILY

(Thermobifida
fusca) 		no annotation 5 ARG B 352
ALA B 338
TYR B 356
PRO B 357
ALA B 358
 None
 1.36A 6bm5A-6c66B:
undetectable		 6bm5A-6c66B:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eoe 78 KDA
GLUCOSE-REGULATED
PROTEIN

(Cricetulus
griseus) 		no annotation 5 PRO A 106
PRO A 421
PRO A 173
ALA A 174
TYR A 175
 None
None
SO4  A 602 ( 4.3A)
None
None
 1.33A 6bm5A-6eoeA:
undetectable		 6bm5A-6eoeA:
21.69