SIMILAR PATTERNS OF AMINO ACIDS FOR 6BKL_G_EU7G101

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1a3g BRANCHED-CHAIN AMINO
ACID
AMINOTRANSFERASE

(Escherichia
coli) 		PF01063
(Aminotran_4) 		5 ALA A 184
ALA A 195
GLY A 182
SER A 167
GLY A 171
 None
None
None
PLP  A 413 ( 4.2A)
None
 1.16A 6bklE-1a3gA:
undetectable
6bklF-1a3gA:
undetectable
6bklG-1a3gA:
undetectable
6bklH-1a3gA:
undetectable		 6bklE-1a3gA:
6.88
6bklF-1a3gA:
6.88
6bklG-1a3gA:
6.88
6bklH-1a3gA:
6.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1dab P.69 PERTACTIN

(Bordetella
pertussis) 		PF03212
(Pertactin) 		5 ALA A 182
ALA A 126
SER A 180
GLY A 252
GLY A 104
 None
 1.22A 6bklE-1dabA:
undetectable
6bklF-1dabA:
undetectable
6bklG-1dabA:
undetectable
6bklH-1dabA:
undetectable		 6bklE-1dabA:
5.48
6bklF-1dabA:
5.48
6bklG-1dabA:
5.48
6bklH-1dabA:
5.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jmm PROTEIN I/II
V-REGION

(Streptococcus
mutans) 		PF08363
(GbpC) 		5 ALA A 696
GLY A 772
ALA A 732
SER A 722
GLY A 724
 None
 1.07A 6bklE-1jmmA:
undetectable
6bklF-1jmmA:
undetectable
6bklG-1jmmA:
undetectable
6bklH-1jmmA:
undetectable		 6bklE-1jmmA:
5.11
6bklF-1jmmA:
5.11
6bklG-1jmmA:
5.11
6bklH-1jmmA:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jqi SHORT CHAIN ACYL-COA
DEHYDROGENASE

(Rattus
norvegicus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		5 ALA A  33
ALA A  86
GLY A  84
SER A  87
GLY A  89
 None
 1.14A 6bklE-1jqiA:
undetectable
6bklF-1jqiA:
undetectable
6bklG-1jqiA:
undetectable
6bklH-1jqiA:
undetectable		 6bklE-1jqiA:
5.61
6bklF-1jqiA:
5.61
6bklG-1jqiA:
5.61
6bklH-1jqiA:
5.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k2w SORBITOL
DEHYDROGENASE

(Rhodobacter
sphaeroides) 		PF13561
(adh_short_C2) 		5 ALA A  22
ALA A  14
GLY A  18
ALA A  35
GLY A  12
 None
 1.05A 6bklE-1k2wA:
undetectable
6bklF-1k2wA:
undetectable
6bklG-1k2wA:
undetectable
6bklH-1k2wA:
undetectable		 6bklE-1k2wA:
7.46
6bklF-1k2wA:
7.46
6bklG-1k2wA:
7.46
6bklH-1k2wA:
7.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k3k FUNCTIONAL
ANTI-APOPTOTIC
FACTOR VBCL-2
HOMOLOG

(Human
gammaherpesvirus
8) 		PF00452
(Bcl-2) 		5 ALA A 111
ALA A  98
GLY A  94
ALA A  19
GLY A  21
 None
 1.16A 6bklE-1k3kA:
undetectable
6bklF-1k3kA:
undetectable
6bklG-1k3kA:
undetectable
6bklH-1k3kA:
undetectable		 6bklE-1k3kA:
10.53
6bklF-1k3kA:
10.53
6bklG-1k3kA:
10.53
6bklH-1k3kA:
10.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1sp8 4-HYDROXYPHENYLPYRUV
ATE DIOXYGENASE

(Zea mays) 		PF00903
(Glyoxalase) 		5 ALA A 157
SER A 152
ALA A 160
ALA A 173
GLY A 162
 None
 1.11A 6bklE-1sp8A:
undetectable
6bklF-1sp8A:
undetectable
6bklG-1sp8A:
undetectable
6bklH-1sp8A:
undetectable		 6bklE-1sp8A:
4.34
6bklF-1sp8A:
4.34
6bklG-1sp8A:
4.34
6bklH-1sp8A:
4.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1to3 PUTATIVE ALDOLASE
YIHT

(Salmonella
enterica) 		PF01791
(DeoC) 		5 ALA A  17
SER A  61
GLY A 281
ALA A  12
SER A  13
 None
None
None
BR  A 314 (-4.1A)
None
 1.22A 6bklE-1to3A:
undetectable
6bklF-1to3A:
undetectable
6bklG-1to3A:
undetectable
6bklH-1to3A:
undetectable		 6bklE-1to3A:
6.71
6bklF-1to3A:
6.71
6bklG-1to3A:
6.71
6bklH-1to3A:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ydg TRP REPRESSOR
BINDING PROTEIN WRBA

(Deinococcus
radiodurans) 		PF03358
(FMN_red) 		5 ALA A 122
SER A 121
GLY A 128
ALA A  91
SER A  84
 None
SO4  A1302 (-3.4A)
None
None
None
 0.97A 6bklE-1ydgA:
undetectable
6bklF-1ydgA:
undetectable
6bklG-1ydgA:
undetectable
6bklH-1ydgA:
undetectable		 6bklE-1ydgA:
7.96
6bklF-1ydgA:
7.96
6bklG-1ydgA:
7.96
6bklH-1ydgA:
7.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d6f GLUTAMYL-TRNA(GLN)
AMIDOTRANSFERASE
SUBUNIT D

(Methanothermobacter
thermautotrophicus) 		PF00710
(Asparaginase) 		5 ALA A 174
GLY A 176
ALA A 213
GLY A 201
SER A 206
 None
 1.06A 6bklE-2d6fA:
undetectable
6bklF-2d6fA:
undetectable
6bklG-2d6fA:
undetectable
6bklH-2d6fA:
undetectable		 6bklE-2d6fA:
5.79
6bklF-2d6fA:
5.79
6bklG-2d6fA:
5.79
6bklH-2d6fA:
5.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d8i T-CELL LYMPHOMA
INVASION AND
METASTASIS 1 VARIANT

(Homo sapiens) 		PF00595
(PDZ) 		5 ALA A  64
SER A  50
ALA A  57
SER A  58
GLY A  61
 None
 1.20A 6bklE-2d8iA:
undetectable
6bklF-2d8iA:
undetectable
6bklG-2d8iA:
undetectable
6bklH-2d8iA:
undetectable		 6bklE-2d8iA:
15.38
6bklF-2d8iA:
15.38
6bklG-2d8iA:
15.38
6bklH-2d8iA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dkk CYTOCHROME P450

(Streptomyces
coelicolor) 		PF00067
(p450) 		5 ALA A 210
ALA A 224
GLY A 226
ALA A 235
GLY A 231
 None
 1.12A 6bklE-2dkkA:
undetectable
6bklF-2dkkA:
undetectable
6bklG-2dkkA:
undetectable
6bklH-2dkkA:
undetectable		 6bklE-2dkkA:
5.46
6bklF-2dkkA:
5.46
6bklG-2dkkA:
5.46
6bklH-2dkkA:
5.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eyz V-CRK SARCOMA VIRUS
CT10 ONCOGENE
HOMOLOG ISOFORM A

(Homo sapiens) 		PF00017
(SH2)
PF00018
(SH3_1)
PF07653
(SH3_2) 		5 SER A  43
SER A  83
GLY A  81
SER A  85
GLY A  66
 None
 1.20A 6bklE-2eyzA:
undetectable
6bklF-2eyzA:
undetectable
6bklG-2eyzA:
undetectable
6bklH-2eyzA:
undetectable		 6bklE-2eyzA:
6.12
6bklF-2eyzA:
6.12
6bklG-2eyzA:
6.12
6bklH-2eyzA:
6.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2foi ENOYL-ACYL CARRIER
REDUCTASE

(Plasmodium
falciparum) 		PF13561
(adh_short_C2) 		5 ALA A 284
ALA A 219
GLY A 280
GLY A 233
SER A 239
 None
JPA  A 500 (-4.0A)
None
None
None
 1.16A 6bklE-2foiA:
undetectable
6bklF-2foiA:
undetectable
6bklG-2foiA:
undetectable
6bklH-2foiA:
undetectable		 6bklE-2foiA:
6.93
6bklF-2foiA:
6.93
6bklG-2foiA:
6.93
6bklH-2foiA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fr1 ERYTHROMYCIN
SYNTHASE, ERYAI

(Saccharopolyspora
erythraea) 		PF08659
(KR) 		5 ALA A1818
ALA A1802
SER A1803
GLY A1594
GLY A1811
 None
 1.05A 6bklE-2fr1A:
undetectable
6bklF-2fr1A:
undetectable
6bklG-2fr1A:
undetectable
6bklH-2fr1A:
undetectable		 6bklE-2fr1A:
4.81
6bklF-2fr1A:
4.81
6bklG-2fr1A:
4.81
6bklH-2fr1A:
4.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gzs IROE PROTEIN

(Escherichia
coli) 		PF00756
(Esterase) 		5 SER A 245
ALA A 211
SER A 212
ALA A 293
SER A 294
 None
 1.18A 6bklE-2gzsA:
undetectable
6bklF-2gzsA:
undetectable
6bklG-2gzsA:
undetectable
6bklH-2gzsA:
undetectable		 6bklE-2gzsA:
6.50
6bklF-2gzsA:
6.50
6bklG-2gzsA:
6.50
6bklH-2gzsA:
6.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2j6l ALDEHYDE
DEHYDROGENASE FAMILY
7 MEMBER A1

(Homo sapiens) 		PF00171
(Aldedh) 		5 ALA A 233
GLY A 231
ALA A  56
GLY A 226
SER A  57
 None
NAI  A1501 (-3.4A)
None
None
None
 1.19A 6bklE-2j6lA:
undetectable
6bklF-2j6lA:
undetectable
6bklG-2j6lA:
undetectable
6bklH-2j6lA:
undetectable		 6bklE-2j6lA:
6.17
6bklF-2j6lA:
6.17
6bklG-2j6lA:
6.17
6bklH-2j6lA:
6.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k3n TUSP1

(Nephila
antipodiana) 		PF12042
(RP1-2) 		5 ALA A  46
SER A  45
SER A  47
GLY A  81
SER A  51
 None
 1.22A 6bklE-2k3nA:
undetectable
6bklF-2k3nA:
undetectable
6bklG-2k3nA:
undetectable
6bklH-2k3nA:
undetectable		 6bklE-2k3nA:
12.80
6bklF-2k3nA:
12.80
6bklG-2k3nA:
12.80
6bklH-2k3nA:
12.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN

(Porphyromonas
gingivalis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		5 ALA A  29
GLY A 141
ALA A  61
GLY A 143
SER A  62
 ALA  A  29 ( 0.0A)
GLY  A 141 ( 0.0A)
ALA  A  61 ( 0.0A)
GLY  A 143 ( 0.0A)
SER  A  62 ( 0.0A)
 1.09A 6bklE-2nvvA:
undetectable
6bklF-2nvvA:
undetectable
6bklG-2nvvA:
undetectable
6bklH-2nvvA:
undetectable		 6bklE-2nvvA:
11.88
6bklF-2nvvA:
11.88
6bklG-2nvvA:
11.88
6bklH-2nvvA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2nvv ACETYL-COA
HYDROLASE/TRANSFERAS
E FAMILY PROTEIN

(Porphyromonas
gingivalis) 		PF02550
(AcetylCoA_hydro)
PF13336
(AcetylCoA_hyd_C) 		5 ALA A  29
SER A 306
GLY A 141
GLY A 143
SER A  62
 ALA  A  29 ( 0.0A)
SER  A 306 ( 0.0A)
GLY  A 141 ( 0.0A)
GLY  A 143 ( 0.0A)
SER  A  62 ( 0.0A)
 1.18A 6bklE-2nvvA:
undetectable
6bklF-2nvvA:
undetectable
6bklG-2nvvA:
undetectable
6bklH-2nvvA:
undetectable		 6bklE-2nvvA:
11.88
6bklF-2nvvA:
11.88
6bklG-2nvvA:
11.88
6bklH-2nvvA:
11.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqk NEUROPILIN-2

(Homo sapiens) 		PF00431
(CUB)
PF00754
(F5_F8_type_C) 		5 ALA A 390
ALA A 419
GLY A 346
GLY A 317
SER A 349
 None
 1.12A 6bklE-2qqkA:
undetectable
6bklF-2qqkA:
undetectable
6bklG-2qqkA:
undetectable
6bklH-2qqkA:
undetectable		 6bklE-2qqkA:
3.36
6bklF-2qqkA:
3.36
6bklG-2qqkA:
3.36
6bklH-2qqkA:
3.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qqo NEUROPILIN-2

(Homo sapiens) 		PF00431
(CUB)
PF00754
(F5_F8_type_C) 		5 ALA A 390
ALA A 419
GLY A 346
GLY A 317
SER A 349
 None
TRS  A 602 ( 4.7A)
None
None
None
 1.12A 6bklE-2qqoA:
undetectable
6bklF-2qqoA:
undetectable
6bklG-2qqoA:
undetectable
6bklH-2qqoA:
undetectable		 6bklE-2qqoA:
4.25
6bklF-2qqoA:
4.25
6bklG-2qqoA:
4.25
6bklH-2qqoA:
4.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vf1 CAPSID PROTEIN

(Rabbit
picobirnavirus) 		no annotation 5 SER A 520
GLY A 377
ALA A 515
SER A 514
GLY A 517
 None
 1.16A 6bklE-2vf1A:
undetectable
6bklF-2vf1A:
undetectable
6bklG-2vf1A:
undetectable
6bklH-2vf1A:
undetectable		 6bklE-2vf1A:
5.28
6bklF-2vf1A:
5.28
6bklG-2vf1A:
5.28
6bklH-2vf1A:
5.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3a1i AMIDASE

(Rhodococcus sp.
N-771) 		PF01425
(Amidase) 		5 ALA A 429
SER A 430
ALA A 168
SER A 150
GLY A 170
 None
 1.21A 6bklE-3a1iA:
undetectable
6bklF-3a1iA:
undetectable
6bklG-3a1iA:
undetectable
6bklH-3a1iA:
undetectable		 6bklE-3a1iA:
4.46
6bklF-3a1iA:
4.46
6bklG-3a1iA:
4.46
6bklH-3a1iA:
4.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3am3 ENOYL-ACP REDUCTASE

(Plasmodium
falciparum) 		PF13561
(adh_short_C2) 		5 ALA A 284
ALA A 219
GLY A 280
GLY A 233
SER A 239
 None
TCL  A 802 (-3.8A)
None
None
None
 1.21A 6bklE-3am3A:
undetectable
6bklF-3am3A:
undetectable
6bklG-3am3A:
undetectable
6bklH-3am3A:
undetectable		 6bklE-3am3A:
3.95
6bklF-3am3A:
3.95
6bklG-3am3A:
3.95
6bklH-3am3A:
3.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3amj ZINC PEPTIDASE
INACTIVE SUBUNIT

(Sphingomonas
sp. A1) 		PF00675
(Peptidase_M16)
PF05193
(Peptidase_M16_C) 		5 ALA B  67
SER B  68
ALA B 107
SER B  56
GLY B  55
 None
 1.17A 6bklE-3amjB:
undetectable
6bklF-3amjB:
undetectable
6bklG-3amjB:
undetectable
6bklH-3amjB:
undetectable		 6bklE-3amjB:
5.28
6bklF-3amjB:
5.28
6bklG-3amjB:
5.28
6bklH-3amjB:
5.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3bxh CENTRAL GLYCOLYTIC
GENE REGULATOR

(Bacillus
subtilis) 		PF04198
(Sugar-bind) 		5 ALA A 313
ALA A 305
GLY A 242
ALA A 303
GLY A 240
 None
None
F6P  A 401 (-3.5A)
None
F6P  A 401 ( 4.1A)
 1.10A 6bklE-3bxhA:
undetectable
6bklF-3bxhA:
undetectable
6bklG-3bxhA:
undetectable
6bklH-3bxhA:
undetectable		 6bklE-3bxhA:
7.06
6bklF-3bxhA:
7.06
6bklG-3bxhA:
7.06
6bklH-3bxhA:
7.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c2q UNCHARACTERIZED
CONSERVED PROTEIN

(Methanococcus
maripaludis) 		no annotation 5 SER A 256
ALA A 251
SER A 250
GLY A 254
ALA A 277
 None
 1.21A 6bklE-3c2qA:
undetectable
6bklF-3c2qA:
undetectable
6bklG-3c2qA:
undetectable
6bklH-3c2qA:
undetectable		 6bklE-3c2qA:
4.68
6bklF-3c2qA:
4.68
6bklG-3c2qA:
4.68
6bklH-3c2qA:
4.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e7f 6-PHOSPHOGLUCONOLACT
ONASE

(Trypanosoma
brucei) 		PF01182
(Glucosamine_iso) 		5 ALA A 167
SER A 168
ALA A  43
GLY A 159
GLY A  45
 None
6PG  A 843 ( 4.8A)
None
6PG  A 843 ( 4.4A)
6PG  A 843 ( 3.8A)
 1.20A 6bklE-3e7fA:
undetectable
6bklF-3e7fA:
undetectable
6bklG-3e7fA:
undetectable
6bklH-3e7fA:
undetectable		 6bklE-3e7fA:
6.84
6bklF-3e7fA:
6.84
6bklG-3e7fA:
6.84
6bklH-3e7fA:
6.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3enk UDP-GLUCOSE
4-EPIMERASE

(Burkholderia
pseudomallei) 		PF16363
(GDP_Man_Dehyd) 		5 ALA A  21
ALA A  13
GLY A  17
ALA A  34
GLY A  11
 None
NAD  A 341 ( 4.5A)
None
None
NAD  A 341 (-3.4A)
 0.93A 6bklE-3enkA:
undetectable
6bklF-3enkA:
undetectable
6bklG-3enkA:
undetectable
6bklH-3enkA:
undetectable		 6bklE-3enkA:
7.84
6bklF-3enkA:
7.84
6bklG-3enkA:
7.84
6bklH-3enkA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g7j GLUTATHIONE
TRANSFERASE GST1-4

(Anopheles dirus) 		PF02798
(GST_N)
PF13410
(GST_C_2) 		5 ALA A 178
ALA A 209
GLY A 213
ALA A  10
GLY A   8
 None
None
None
None
GTX  A 220 (-3.7A)
 1.05A 6bklE-3g7jA:
undetectable
6bklF-3g7jA:
undetectable
6bklG-3g7jA:
undetectable
6bklH-3g7jA:
undetectable		 6bklE-3g7jA:
9.14
6bklF-3g7jA:
9.14
6bklG-3g7jA:
9.14
6bklH-3g7jA:
9.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gg4 GLYCEROL KINASE

(Yersinia
pseudotuberculosis) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		5 ALA A 476
ALA A 258
GLY A 262
ALA A 482
SER A 481
 None
 1.21A 6bklE-3gg4A:
undetectable
6bklF-3gg4A:
undetectable
6bklG-3gg4A:
undetectable
6bklH-3gg4A:
undetectable		 6bklE-3gg4A:
4.84
6bklF-3gg4A:
4.84
6bklG-3gg4A:
4.84
6bklH-3gg4A:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hhd FATTY ACID SYNTHASE

(Homo sapiens) 		PF00109
(ketoacyl-synt)
PF00698
(Acyl_transf_1)
PF02801
(Ketoacyl-synt_C)
PF16197
(KAsynt_C_assoc) 		5 ALA A 340
ALA A 292
ALA A 214
GLY A 294
SER A 327
 None
 1.18A 6bklE-3hhdA:
undetectable
6bklF-3hhdA:
undetectable
6bklG-3hhdA:
undetectable
6bklH-3hhdA:
undetectable		 6bklE-3hhdA:
2.45
6bklF-3hhdA:
2.45
6bklG-3hhdA:
2.45
6bklH-3hhdA:
2.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3htx HEN1

(Arabidopsis
thaliana) 		PF13847
(Methyltransf_31) 		5 SER A 347
SER A 274
GLY A 268
ALA A 327
SER A 328
 None
 1.07A 6bklE-3htxA:
undetectable
6bklF-3htxA:
undetectable
6bklG-3htxA:
undetectable
6bklH-3htxA:
undetectable		 6bklE-3htxA:
2.67
6bklF-3htxA:
2.67
6bklG-3htxA:
2.67
6bklH-3htxA:
2.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihj ALANINE
AMINOTRANSFERASE 2

(Homo sapiens) 		PF00155
(Aminotran_1_2) 		5 ALA A 187
SER A 338
GLY A 352
SER A 188
GLY A 190
 PLP  A   1 (-3.6A)
PLP  A   1 (-2.6A)
None
PLP  A   1 (-2.7A)
None
 1.19A 6bklE-3ihjA:
undetectable
6bklF-3ihjA:
undetectable
6bklG-3ihjA:
undetectable
6bklH-3ihjA:
undetectable		 6bklE-3ihjA:
5.40
6bklF-3ihjA:
5.40
6bklG-3ihjA:
5.40
6bklH-3ihjA:
5.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3il4 3-OXOACYL-[ACYL-CARR
IER-PROTEIN]
SYNTHASE 3

(Enterococcus
faecalis) 		PF08541
(ACP_syn_III_C)
PF08545
(ACP_syn_III) 		5 ALA A 284
SER A 285
ALA A  84
GLY A 144
ALA A 116
 None
 1.22A 6bklE-3il4A:
undetectable
6bklF-3il4A:
undetectable
6bklG-3il4A:
undetectable
6bklH-3il4A:
undetectable		 6bklE-3il4A:
5.96
6bklF-3il4A:
5.96
6bklG-3il4A:
5.96
6bklH-3il4A:
5.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iox AGI/II

(Streptococcus
mutans) 		PF06696
(Strep_SA_rep)
PF08363
(GbpC) 		5 ALA A 696
GLY A 772
ALA A 732
SER A 722
GLY A 724
 PMS  A 900 ( 4.8A)
None
None
None
None
 1.07A 6bklE-3ioxA:
undetectable
6bklF-3ioxA:
undetectable
6bklG-3ioxA:
undetectable
6bklH-3ioxA:
undetectable		 6bklE-3ioxA:
3.67
6bklF-3ioxA:
3.67
6bklG-3ioxA:
3.67
6bklH-3ioxA:
3.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3kxq TRIOSEPHOSPHATE
ISOMERASE

(Bartonella
henselae) 		PF00121
(TIM) 		5 ALA A  84
SER A  83
ALA A  92
ALA A  48
GLY A  67
 None
 1.12A 6bklE-3kxqA:
undetectable
6bklF-3kxqA:
undetectable
6bklG-3kxqA:
undetectable
6bklH-3kxqA:
undetectable		 6bklE-3kxqA:
6.91
6bklF-3kxqA:
6.91
6bklG-3kxqA:
6.91
6bklH-3kxqA:
6.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lma STAGE V SPORULATION
PROTEIN AD (SPOVAD)

(Bacillus
licheniformis) 		PF07451
(SpoVAD) 		5 ALA A 306
SER A 111
ALA A 280
GLY A 233
GLY A 278
 None
 1.21A 6bklE-3lmaA:
undetectable
6bklF-3lmaA:
undetectable
6bklG-3lmaA:
undetectable
6bklH-3lmaA:
undetectable		 6bklE-3lmaA:
7.67
6bklF-3lmaA:
7.67
6bklG-3lmaA:
7.67
6bklH-3lmaA:
7.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lxu TRIPEPTIDYL-PEPTIDAS
E 2

(Drosophila
melanogaster) 		PF00082
(Peptidase_S8)
PF12580
(TPPII)
PF12583
(TPPII_N) 		5 ALA X 370
ALA X 372
SER X 371
GLY X 395
GLY X 434
 None
 1.14A 6bklE-3lxuX:
undetectable
6bklF-3lxuX:
undetectable
6bklG-3lxuX:
undetectable
6bklH-3lxuX:
undetectable		 6bklE-3lxuX:
1.70
6bklF-3lxuX:
1.70
6bklG-3lxuX:
1.70
6bklH-3lxuX:
1.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozv FLAVOHEMOGLOBIN

(Cupriavidus
necator) 		no annotation 5 ALA B 253
ALA B  86
SER B  87
GLY B  89
SER B 144
 None
 1.19A 6bklE-3ozvB:
undetectable
6bklF-3ozvB:
undetectable
6bklG-3ozvB:
undetectable
6bklH-3ozvB:
undetectable		 6bklE-3ozvB:
5.40
6bklF-3ozvB:
5.40
6bklG-3ozvB:
5.40
6bklH-3ozvB:
5.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ozv FLAVOHEMOGLOBIN

(Cupriavidus
necator) 		no annotation 6 SER B 144
ALA B 253
GLY B 153
ALA B  86
SER B  87
GLY B  89
 None
 1.19A 6bklE-3ozvB:
undetectable
6bklF-3ozvB:
undetectable
6bklG-3ozvB:
undetectable
6bklH-3ozvB:
undetectable		 6bklE-3ozvB:
5.40
6bklF-3ozvB:
5.40
6bklG-3ozvB:
5.40
6bklH-3ozvB:
5.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pi7 NADH OXIDOREDUCTASE

(Mesorhizobium
loti) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		5 SER A 118
ALA A 108
GLY A  88
ALA A 144
GLY A 142
 None
 1.14A 6bklE-3pi7A:
undetectable
6bklF-3pi7A:
undetectable
6bklG-3pi7A:
undetectable
6bklH-3pi7A:
undetectable		 6bklE-3pi7A:
8.24
6bklF-3pi7A:
8.24
6bklG-3pi7A:
8.24
6bklH-3pi7A:
8.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3snh DYNAMIN-1

(Homo sapiens) 		PF00169
(PH)
PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		5 ALA A  42
SER A  41
ALA A 186
GLY A  38
SER A 184
 None
 1.22A 6bklE-3snhA:
undetectable
6bklF-3snhA:
undetectable
6bklG-3snhA:
undetectable
6bklH-3snhA:
undetectable		 6bklE-3snhA:
2.99
6bklF-3snhA:
2.99
6bklG-3snhA:
2.99
6bklH-3snhA:
2.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3snh DYNAMIN-1

(Homo sapiens) 		PF00169
(PH)
PF00350
(Dynamin_N)
PF01031
(Dynamin_M)
PF02212
(GED) 		5 ALA A  42
SER A  41
ALA A 186
GLY A  38
SER A 184
 None
 1.22A 6bklE-3snhA:
undetectable
6bklF-3snhA:
undetectable
6bklG-3snhA:
undetectable
6bklH-3snhA:
undetectable		 6bklE-3snhA:
2.99
6bklF-3snhA:
2.99
6bklG-3snhA:
2.99
6bklH-3snhA:
2.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugm TAL EFFECTOR
AVRBS3/PTHA

(Xanthomonas
oryzae) 		PF03377
(TAL_effector) 		5 ALA A 705
SER A 706
GLY A 710
ALA A 739
GLY A 744
 None
 1.14A 6bklE-3ugmA:
undetectable
6bklF-3ugmA:
undetectable
6bklG-3ugmA:
undetectable
6bklH-3ugmA:
undetectable		 6bklE-3ugmA:
2.43
6bklF-3ugmA:
2.43
6bklG-3ugmA:
2.43
6bklH-3ugmA:
2.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ugm TAL EFFECTOR
AVRBS3/PTHA

(Xanthomonas
oryzae) 		PF03377
(TAL_effector) 		5 SER A 706
GLY A 710
ALA A 739
SER A 740
GLY A 744
 None
 1.17A 6bklE-3ugmA:
undetectable
6bklF-3ugmA:
undetectable
6bklG-3ugmA:
undetectable
6bklH-3ugmA:
undetectable		 6bklE-3ugmA:
2.43
6bklF-3ugmA:
2.43
6bklG-3ugmA:
2.43
6bklH-3ugmA:
2.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3umm PHOSPHORIBOSYLFORMYL
GLYCINAMIDINE
SYNTHASE

(Salmonella
enterica) 		PF02769
(AIRS_C)
PF13507
(GATase_5) 		5 ALA A 621
SER A 398
GLY A 623
ALA A 840
GLY A 851
 None
 0.86A 6bklE-3ummA:
undetectable
6bklF-3ummA:
undetectable
6bklG-3ummA:
undetectable
6bklH-3ummA:
undetectable		 6bklE-3ummA:
1.92
6bklF-3ummA:
1.92
6bklG-3ummA:
1.92
6bklH-3ummA:
1.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3v30 DNA-BINDING PROTEIN
RFXANK

(Homo sapiens) 		PF12796
(Ank_2)
PF13606
(Ank_3) 		5 ALA A 208
ALA A 197
ALA A 164
SER A 165
GLY A 168
 None
 1.11A 6bklE-3v30A:
undetectable
6bklF-3v30A:
undetectable
6bklG-3v30A:
undetectable
6bklH-3v30A:
undetectable		 6bklE-3v30A:
9.88
6bklF-3v30A:
9.88
6bklG-3v30A:
9.88
6bklH-3v30A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wbk EUKARYOTIC
TRANSLATION
INITIATION FACTOR 5B

(Saccharomyces
cerevisiae) 		PF00009
(GTP_EFTU)
PF03144
(GTP_EFTU_D2)
PF11987
(IF-2) 		5 ALA A 359
GLY A 383
SER A 360
GLY A 385
SER A 317
 None
 1.03A 6bklE-3wbkA:
undetectable
6bklF-3wbkA:
undetectable
6bklG-3wbkA:
undetectable
6bklH-3wbkA:
undetectable		 6bklE-3wbkA:
3.70
6bklF-3wbkA:
3.70
6bklG-3wbkA:
3.70
6bklH-3wbkA:
3.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3x29 CLAUDIN-19

(Mus musculus) 		PF00822
(PMP22_Claudin) 		5 ALA A  87
GLY A  91
ALA A 172
GLY A 130
SER A 171
 None
 1.16A 6bklE-3x29A:
undetectable
6bklF-3x29A:
undetectable
6bklG-3x29A:
undetectable
6bklH-3x29A:
undetectable		 6bklE-3x29A:
10.29
6bklF-3x29A:
10.29
6bklG-3x29A:
10.29
6bklH-3x29A:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuc CELLULOSOMAL
SCAFFOLDIN

(Acetivibrio
cellulolyticus) 		PF00942
(CBM_3) 		5 ALA A  90
ALA A  39
ALA A  94
SER A  93
GLY A  96
 None
 1.07A 6bklE-3zucA:
undetectable
6bklF-3zucA:
undetectable
6bklG-3zucA:
undetectable
6bklH-3zucA:
undetectable		 6bklE-3zucA:
6.54
6bklF-3zucA:
6.54
6bklG-3zucA:
6.54
6bklH-3zucA:
6.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bem F1FO ATPASE C1
SUBUNIT

(Acetobacterium
woodii) 		PF00137
(ATP-synt_C) 		5 ALA J 112
SER J 109
ALA J  29
SER J  28
GLY J  31
 None
 0.94A 6bklE-4bemJ:
undetectable
6bklF-4bemJ:
undetectable
6bklG-4bemJ:
undetectable
6bklH-4bemJ:
undetectable		 6bklE-4bemJ:
9.77
6bklF-4bemJ:
9.77
6bklG-4bemJ:
9.77
6bklH-4bemJ:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bem F1FO ATPASE C1
SUBUNIT

(Acetobacterium
woodii) 		PF00137
(ATP-synt_C) 		5 ALA J 112
SER J 109
ALA J  29
SER J  28
GLY J  31
 None
 0.99A 6bklE-4bemJ:
undetectable
6bklF-4bemJ:
undetectable
6bklG-4bemJ:
undetectable
6bklH-4bemJ:
undetectable		 6bklE-4bemJ:
9.77
6bklF-4bemJ:
9.77
6bklG-4bemJ:
9.77
6bklH-4bemJ:
9.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bxj AMPDH3

(Pseudomonas
aeruginosa) 		PF01510
(Amidase_2) 		5 ALA A  37
SER A  34
ALA A  43
GLY A  41
ALA A  45
 None
 1.09A 6bklE-4bxjA:
undetectable
6bklF-4bxjA:
undetectable
6bklG-4bxjA:
undetectable
6bklH-4bxjA:
undetectable		 6bklE-4bxjA:
6.80
6bklF-4bxjA:
6.80
6bklG-4bxjA:
6.80
6bklH-4bxjA:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4dzt AQUALYSIN-1

(Thermus
aquaticus) 		PF00082
(Peptidase_S8) 		5 SER A 274
ALA A  86
GLY A 230
ALA A  28
GLY A  30
 None
 1.21A 6bklE-4dztA:
undetectable
6bklF-4dztA:
undetectable
6bklG-4dztA:
undetectable
6bklH-4dztA:
undetectable		 6bklE-4dztA:
5.43
6bklF-4dztA:
5.43
6bklG-4dztA:
5.43
6bklH-4dztA:
5.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4e6p PROBABLE SORBITOL
DEHYDROGENASE
(L-IDITOL
2-DEHYDROGENASE)

(Sinorhizobium
meliloti) 		PF13561
(adh_short_C2) 		5 ALA A  23
ALA A  15
GLY A  19
ALA A  36
GLY A  13
 None
 1.06A 6bklE-4e6pA:
undetectable
6bklF-4e6pA:
undetectable
6bklG-4e6pA:
undetectable
6bklH-4e6pA:
undetectable		 6bklE-4e6pA:
8.37
6bklF-4e6pA:
8.37
6bklG-4e6pA:
8.37
6bklH-4e6pA:
8.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4foz PORIN D

(Pseudomonas
aeruginosa) 		PF03573
(OprD) 		5 ALA A 199
SER A 200
ALA A 192
SER A 198
GLY A 149
 None
 1.15A 6bklE-4fozA:
undetectable
6bklF-4fozA:
undetectable
6bklG-4fozA:
undetectable
6bklH-4fozA:
undetectable		 6bklE-4fozA:
3.99
6bklF-4fozA:
3.99
6bklG-4fozA:
3.99
6bklH-4fozA:
3.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4h7u PYRANOSE
DEHYDROGENASE

(Leucoagaricus
meleagris) 		PF00732
(GMC_oxred_N)
PF05199
(GMC_oxred_C) 		5 ALA A  63
SER A  64
ALA A 360
GLY A 105
ALA A 394
 None
None
None
FED  A 801 (-3.1A)
None
 1.01A 6bklE-4h7uA:
undetectable
6bklF-4h7uA:
undetectable
6bklG-4h7uA:
undetectable
6bklH-4h7uA:
undetectable		 6bklE-4h7uA:
4.42
6bklF-4h7uA:
4.42
6bklG-4h7uA:
4.42
6bklH-4h7uA:
4.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kam O-ACETYLHOMOSERINE
SULFHYDRYLASE METC

(Mycobacterium
marinum) 		PF01053
(Cys_Met_Meta_PP) 		5 ALA A 218
SER A 217
ALA A 228
GLY A 223
GLY A 226
 None
SO4  A 501 (-2.7A)
None
None
None
 1.14A 6bklE-4kamA:
undetectable
6bklF-4kamA:
undetectable
6bklG-4kamA:
undetectable
6bklH-4kamA:
undetectable		 6bklE-4kamA:
4.05
6bklF-4kamA:
4.05
6bklG-4kamA:
4.05
6bklH-4kamA:
4.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lgl GLYCINE
DEHYDROGENASE
[DECARBOXYLATING]

(Synechocystis
sp. PCC 6803) 		PF02347
(GDC-P) 		5 ALA A 363
SER A 364
ALA A 302
ALA A 164
SER A 165
 None
 1.12A 6bklE-4lglA:
undetectable
6bklF-4lglA:
undetectable
6bklG-4lglA:
undetectable
6bklH-4lglA:
undetectable		 6bklE-4lglA:
2.79
6bklF-4lglA:
2.79
6bklG-4lglA:
2.79
6bklH-4lglA:
2.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4m9p FILAMIN-A

(Homo sapiens) 		PF00630
(Filamin) 		5 ALA A 595
SER A 594
GLY A 589
SER A 748
GLY A 750
 None
 1.14A 6bklE-4m9pA:
undetectable
6bklF-4m9pA:
undetectable
6bklG-4m9pA:
undetectable
6bklH-4m9pA:
undetectable		 6bklE-4m9pA:
7.21
6bklF-4m9pA:
7.21
6bklG-4m9pA:
7.21
6bklH-4m9pA:
7.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4mpt PUTATIVE
LEU/ILE/VAL-BINDING
PROTEIN

(Bordetella
pertussis) 		PF13458
(Peripla_BP_6) 		5 ALA A 216
ALA A 237
GLY A 212
ALA A 208
GLY A 210
 None
 1.21A 6bklE-4mptA:
undetectable
6bklF-4mptA:
undetectable
6bklG-4mptA:
undetectable
6bklH-4mptA:
undetectable		 6bklE-4mptA:
5.32
6bklF-4mptA:
5.32
6bklG-4mptA:
5.32
6bklH-4mptA:
5.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nbu 3-OXOACYL-(ACYL-CARR
IER-PROTEIN)
REDUCTASE

(Bacillus sp.
SG-1) 		PF13561
(adh_short_C2) 		5 ALA A  30
ALA A  22
GLY A  26
ALA A  43
GLY A  20
 None
NAI  A 301 ( 4.2A)
None
None
NAI  A 301 (-3.3A)
 0.98A 6bklE-4nbuA:
undetectable
6bklF-4nbuA:
undetectable
6bklG-4nbuA:
undetectable
6bklH-4nbuA:
undetectable		 6bklE-4nbuA:
7.00
6bklF-4nbuA:
7.00
6bklG-4nbuA:
7.00
6bklH-4nbuA:
7.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pe8 TAT-LINKED QUALITY
CONTROL PROTEIN TATD

(Escherichia
coli) 		PF01026
(TatD_DNase) 		5 ALA A  45
ALA A  59
GLY A  36
ALA A  88
GLY A  90
 None
 1.13A 6bklE-4pe8A:
undetectable
6bklF-4pe8A:
undetectable
6bklG-4pe8A:
undetectable
6bklH-4pe8A:
undetectable		 6bklE-4pe8A:
7.81
6bklF-4pe8A:
7.81
6bklG-4pe8A:
7.81
6bklH-4pe8A:
7.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q1q ADHESIN/INVASIN TIBA
AUTOTRANSPORTER

(Escherichia
coli) 		PF16168
(AIDA) 		5 SER A 211
GLY A 228
ALA A 249
SER A 248
GLY A 247
 289  A 416 (-2.7A)
None
None
289  A 417 (-1.3A)
None
 1.17A 6bklE-4q1qA:
undetectable
6bklF-4q1qA:
undetectable
6bklG-4q1qA:
undetectable
6bklH-4q1qA:
undetectable		 6bklE-4q1qA:
4.92
6bklF-4q1qA:
4.92
6bklG-4q1qA:
4.92
6bklH-4q1qA:
4.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4qdr NEUROPILIN-2

(Homo sapiens) 		PF00754
(F5_F8_type_C) 		5 ALA A 390
ALA A 419
GLY A 346
GLY A 317
SER A 349
 None
 1.17A 6bklE-4qdrA:
undetectable
6bklF-4qdrA:
undetectable
6bklG-4qdrA:
undetectable
6bklH-4qdrA:
undetectable		 6bklE-4qdrA:
6.31
6bklF-4qdrA:
6.31
6bklG-4qdrA:
6.31
6bklH-4qdrA:
6.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rg1 C9ORF114

(Homo sapiens) 		PF02598
(Methyltrn_RNA_3) 		5 ALA A 323
GLY A 320
ALA A 272
SER A 271
SER A 268
 None
 1.04A 6bklE-4rg1A:
undetectable
6bklF-4rg1A:
undetectable
6bklG-4rg1A:
undetectable
6bklH-4rg1A:
undetectable		 6bklE-4rg1A:
5.63
6bklF-4rg1A:
5.63
6bklG-4rg1A:
5.63
6bklH-4rg1A:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rxl MOLYBDENUM ABC
TRANSPORTER,
PERIPLASMIC
MOLYBDENUM-BINDING
PROTEIN

(Vibrio cholerae) 		PF13531
(SBP_bac_11) 		5 ALA A  31
SER A  33
SER A  60
GLY A  58
ALA A 139
 WO4  A 301 (-3.3A)
WO4  A 301 (-2.4A)
WO4  A 301 (-2.3A)
None
WO4  A 301 ( 4.9A)
 0.97A 6bklE-4rxlA:
undetectable
6bklF-4rxlA:
undetectable
6bklG-4rxlA:
undetectable
6bklH-4rxlA:
undetectable		 6bklE-4rxlA:
7.89
6bklF-4rxlA:
7.89
6bklG-4rxlA:
7.89
6bklH-4rxlA:
7.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s1p UNCHARACTERIZED
PROTEIN

(Slackia
heliotrinireducens) 		PF13472
(Lipase_GDSL_2) 		5 ALA A 168
SER A 166
ALA A 154
SER A 153
GLY A 152
 None
 1.10A 6bklE-4s1pA:
undetectable
6bklF-4s1pA:
undetectable
6bklG-4s1pA:
undetectable
6bklH-4s1pA:
undetectable		 6bklE-4s1pA:
7.95
6bklF-4s1pA:
7.95
6bklG-4s1pA:
7.95
6bklH-4s1pA:
7.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4trr PUTATIVE
D-BETA-HYDROXYBUTYRA
TE DEHYDROGENASE

(Burkholderia
cenocepacia) 		PF00106
(adh_short) 		5 ALA A  23
ALA A  15
GLY A  19
ALA A  36
GLY A  13
 None
None
SO4  A 301 (-4.2A)
None
None
 1.18A 6bklE-4trrA:
undetectable
6bklF-4trrA:
undetectable
6bklG-4trrA:
undetectable
6bklH-4trrA:
undetectable		 6bklE-4trrA:
11.80
6bklF-4trrA:
11.80
6bklG-4trrA:
11.80
6bklH-4trrA:
11.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w65 GLYCOSYL HYDROLASE
FAMILY PROTEIN

(Mycolicibacterium
fortuitum) 		PF00722
(Glyco_hydro_16) 		5 ALA A 113
ALA A 253
GLY A 122
ALA A 255
GLY A  92
 ALA  A 113 ( 0.0A)
ALA  A 253 ( 0.0A)
GLY  A 122 ( 0.0A)
ALA  A 255 ( 0.0A)
GLY  A  92 ( 0.0A)
 1.19A 6bklE-4w65A:
undetectable
6bklF-4w65A:
undetectable
6bklG-4w65A:
undetectable
6bklH-4w65A:
undetectable		 6bklE-4w65A:
5.73
6bklF-4w65A:
5.73
6bklG-4w65A:
5.73
6bklH-4w65A:
5.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4w7v CELLULASE

(Xanthomonas
citri) 		PF00150
(Cellulase) 		5 ALA A 140
ALA A 169
GLY A 167
GLY A 172
SER A 178
 None
 1.04A 6bklE-4w7vA:
undetectable
6bklF-4w7vA:
undetectable
6bklG-4w7vA:
undetectable
6bklH-4w7vA:
undetectable		 6bklE-4w7vA:
5.42
6bklF-4w7vA:
5.42
6bklG-4w7vA:
5.42
6bklH-4w7vA:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wgk NEUTRAL CERAMIDASE

(Homo sapiens) 		PF04734
(Ceramidase_alk)
PF17048
(Ceramidse_alk_C) 		5 ALA A 344
ALA A 141
ALA A 109
SER A 230
GLY A 107
 None
 1.22A 6bklE-4wgkA:
undetectable
6bklF-4wgkA:
undetectable
6bklG-4wgkA:
undetectable
6bklH-4wgkA:
undetectable		 6bklE-4wgkA:
3.74
6bklF-4wgkA:
3.74
6bklG-4wgkA:
3.74
6bklH-4wgkA:
3.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xox 3-OXOACYL-ACP
SYNTHASE

(Vibrio cholerae) 		PF00109
(ketoacyl-synt)
PF02801
(Ketoacyl-synt_C) 		5 ALA A  71
SER A 104
GLY A 188
GLY A 186
SER A 141
 None
 1.21A 6bklE-4xoxA:
undetectable
6bklF-4xoxA:
undetectable
6bklG-4xoxA:
undetectable
6bklH-4xoxA:
undetectable		 6bklE-4xoxA:
4.27
6bklF-4xoxA:
4.27
6bklG-4xoxA:
4.27
6bklH-4xoxA:
4.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xzb CELA

(Geobacillus sp.
70PC53) 		PF00150
(Cellulase) 		5 ALA A 273
SER A 235
GLY A 242
ALA A 248
SER A 206
 None
 1.20A 6bklE-4xzbA:
undetectable
6bklF-4xzbA:
undetectable
6bklG-4xzbA:
undetectable
6bklH-4xzbA:
undetectable		 6bklE-4xzbA:
5.80
6bklF-4xzbA:
5.80
6bklG-4xzbA:
5.80
6bklH-4xzbA:
5.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xze NUCLEOPROTEIN

(Hazara
orthonairovirus) 		PF02477
(Nairo_nucleo) 		5 SER A  35
ALA A 397
GLY A 409
ALA A 415
GLY A 411
 None
 1.22A 6bklE-4xzeA:
undetectable
6bklF-4xzeA:
undetectable
6bklG-4xzeA:
undetectable
6bklH-4xzeA:
undetectable		 6bklE-4xzeA:
6.01
6bklF-4xzeA:
6.01
6bklG-4xzeA:
6.01
6bklH-4xzeA:
6.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y90 TRIOSEPHOSPHATE
ISOMERASE

(Deinococcus
radiodurans) 		PF00121
(TIM) 		5 ALA A  81
SER A  80
ALA A  89
ALA A  46
GLY A  64
 None
 1.03A 6bklE-4y90A:
undetectable
6bklF-4y90A:
undetectable
6bklG-4y90A:
undetectable
6bklH-4y90A:
undetectable		 6bklE-4y90A:
7.29
6bklF-4y90A:
7.29
6bklG-4y90A:
7.29
6bklH-4y90A:
7.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yai C
ALPHA-DEHYDROGENASE

(Sphingobium sp.
SYK-6) 		PF00106
(adh_short) 		5 ALA A  22
ALA A  14
GLY A  18
ALA A  35
GLY A  12
 None
NAI  A 500 ( 4.2A)
None
None
NAI  A 500 (-2.8A)
 0.95A 6bklE-4yaiA:
undetectable
6bklF-4yaiA:
undetectable
6bklG-4yaiA:
undetectable
6bklH-4yaiA:
undetectable		 6bklE-4yaiA:
6.71
6bklF-4yaiA:
6.71
6bklG-4yaiA:
6.71
6bklH-4yaiA:
6.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bxp LACTO-N-BIOSIDASE

(Bifidobacterium
bifidum) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b)
PF14200
(RicinB_lectin_2) 		5 ALA A  87
ALA A 105
ALA A 109
GLY A 107
SER A 115
 None
 1.21A 6bklE-5bxpA:
undetectable
6bklF-5bxpA:
undetectable
6bklG-5bxpA:
undetectable
6bklH-5bxpA:
undetectable		 6bklE-5bxpA:
3.26
6bklF-5bxpA:
3.26
6bklG-5bxpA:
3.26
6bklH-5bxpA:
3.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5dn2 NEUROPILIN-2

(Homo sapiens) 		PF00754
(F5_F8_type_C) 		5 ALA A 390
ALA A 419
GLY A 346
GLY A 317
SER A 349
 None
 1.15A 6bklE-5dn2A:
undetectable
6bklF-5dn2A:
undetectable
6bklG-5dn2A:
undetectable
6bklH-5dn2A:
undetectable		 6bklE-5dn2A:
11.33
6bklF-5dn2A:
11.33
6bklG-5dn2A:
11.33
6bklH-5dn2A:
11.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fr8 TONB-DEPENDENT
SIDEROPHORE RECEPTOR

(Acinetobacter
baumannii) 		PF00593
(TonB_dep_Rec)
PF07715
(Plug) 		5 ALA A 463
ALA A 139
GLY A 137
SER A  35
GLY A  37
 None
 1.11A 6bklE-5fr8A:
undetectable
6bklF-5fr8A:
undetectable
6bklG-5fr8A:
undetectable
6bklH-5fr8A:
undetectable		 6bklE-5fr8A:
3.34
6bklF-5fr8A:
3.34
6bklG-5fr8A:
3.34
6bklH-5fr8A:
3.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsb TECTONIN 2

(Laccaria
bicolor) 		no annotation 5 ALA A  53
SER A  14
GLY A  16
ALA A 128
GLY A 169
 None
 0.93A 6bklE-5fsbA:
undetectable
6bklF-5fsbA:
undetectable
6bklG-5fsbA:
undetectable
6bklH-5fsbA:
undetectable		 6bklE-5fsbA:
6.93
6bklF-5fsbA:
6.93
6bklG-5fsbA:
6.93
6bklH-5fsbA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsb TECTONIN 2

(Laccaria
bicolor) 		no annotation 5 ALA A 128
SER A  89
GLY A  91
ALA A 206
GLY A  16
 None
 1.08A 6bklE-5fsbA:
undetectable
6bklF-5fsbA:
undetectable
6bklG-5fsbA:
undetectable
6bklH-5fsbA:
undetectable		 6bklE-5fsbA:
6.93
6bklF-5fsbA:
6.93
6bklG-5fsbA:
6.93
6bklH-5fsbA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5fsb TECTONIN 2

(Laccaria
bicolor) 		no annotation 5 ALA A 206
SER A 167
GLY A 169
ALA A  53
GLY A  91
 None
 1.09A 6bklE-5fsbA:
undetectable
6bklF-5fsbA:
undetectable
6bklG-5fsbA:
undetectable
6bklH-5fsbA:
undetectable		 6bklE-5fsbA:
6.93
6bklF-5fsbA:
6.93
6bklG-5fsbA:
6.93
6bklH-5fsbA:
6.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5iqn PROTEIN FIMG

(Escherichia
coli) 		no annotation 5 ALA A  41
SER A  42
GLY A  39
ALA A 128
GLY A 126
 None
 1.20A 6bklE-5iqnA:
undetectable
6bklF-5iqnA:
undetectable
6bklG-5iqnA:
undetectable
6bklH-5iqnA:
undetectable		 6bklE-5iqnA:
9.85
6bklF-5iqnA:
9.85
6bklG-5iqnA:
9.85
6bklH-5iqnA:
9.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lhk LEUCINE
AMINOPEPTIDASE 2,
CHLOROPLASTIC

(Streptomyces
sp. BC16019) 		PF00883
(Peptidase_M17)
PF02789
(Peptidase_M17_N) 		5 ALA A 283
ALA A 467
GLY A 481
ALA A 290
GLY A 483
 None
 1.16A 6bklE-5lhkA:
undetectable
6bklF-5lhkA:
undetectable
6bklG-5lhkA:
undetectable
6bklH-5lhkA:
undetectable		 6bklE-5lhkA:
4.79
6bklF-5lhkA:
4.79
6bklG-5lhkA:
4.79
6bklH-5lhkA:
4.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5lkm DNA REPAIR PROTEIN
RADA

(Streptococcus
pneumoniae) 		PF13481
(AAA_25)
PF13541
(ChlI) 		5 ALA A 373
SER A 292
GLY A 290
ALA A 356
SER A 355
 None
 1.16A 6bklE-5lkmA:
undetectable
6bklF-5lkmA:
undetectable
6bklG-5lkmA:
undetectable
6bklH-5lkmA:
undetectable		 6bklE-5lkmA:
3.98
6bklF-5lkmA:
3.98
6bklG-5lkmA:
3.98
6bklH-5lkmA:
3.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ll7 BETA-LACTAMASE

(Escherichia
coli) 		no annotation 5 ALA A 286
ALA A 262
ALA A  62
GLY A  45
SER A  59
 None
 1.15A 6bklE-5ll7A:
undetectable
6bklF-5ll7A:
undetectable
6bklG-5ll7A:
undetectable
6bklH-5ll7A:
undetectable		 6bklE-5ll7A:
undetectable
6bklF-5ll7A:
undetectable
6bklG-5ll7A:
undetectable
6bklH-5ll7A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oei UNCHARACTERIZED
PROTEIN FAMILY
UPF0065:TAT PATHWAY
SIGNAL

(Rhodopseudomonas
palustris) 		no annotation 5 ALA A 219
SER A 220
GLY A  52
SER A 169
GLY A 197
 None
None
OOG  A 401 (-3.6A)
OOG  A 401 (-3.0A)
OOG  A 401 ( 3.8A)
 0.94A 6bklE-5oeiA:
undetectable
6bklF-5oeiA:
undetectable
6bklG-5oeiA:
undetectable
6bklH-5oeiA:
undetectable		 6bklE-5oeiA:
10.09
6bklF-5oeiA:
10.09
6bklG-5oeiA:
10.09
6bklH-5oeiA:
10.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tgf UNCHARACTERIZED
PROTEIN

(Bacteroides
dorei) 		PF00144
(Beta-lactamase) 		5 ALA A  57
SER A  58
GLY A  60
ALA A 196
GLY A 202
 GOL  A 401 ( 4.7A)
GOL  A 401 ( 4.1A)
None
None
None
 1.02A 6bklE-5tgfA:
undetectable
6bklF-5tgfA:
undetectable
6bklG-5tgfA:
undetectable
6bklH-5tgfA:
undetectable		 6bklE-5tgfA:
6.06
6bklF-5tgfA:
6.06
6bklG-5tgfA:
6.06
6bklH-5tgfA:
6.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tsb MEMBRANE PROTEIN

(Bordetella
bronchiseptica) 		PF02535
(Zip) 		5 ALA A 235
SER A 236
GLY A 237
ALA A 216
GLY A 212
 None
 1.17A 6bklE-5tsbA:
undetectable
6bklF-5tsbA:
undetectable
6bklG-5tsbA:
undetectable
6bklH-5tsbA:
undetectable		 6bklE-5tsbA:
7.12
6bklF-5tsbA:
7.12
6bklG-5tsbA:
7.12
6bklH-5tsbA:
7.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5tvg ALPHA,ALPHA-TREHALOS
E-PHOSPHATE SYNTHASE
(UDP-FORMING)

(Burkholderia
vietnamiensis) 		PF00982
(Glyco_transf_20) 		5 ALA A  21
SER A  20
ALA A  25
GLY A  23
GLY A  27
 None
 1.08A 6bklE-5tvgA:
undetectable
6bklF-5tvgA:
undetectable
6bklG-5tvgA:
undetectable
6bklH-5tvgA:
undetectable		 6bklE-5tvgA:
5.82
6bklF-5tvgA:
5.82
6bklG-5tvgA:
5.82
6bklH-5tvgA:
5.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5vmb SERINE
HYDROXYMETHYLTRANSFE
RASE

(Acinetobacter
baumannii) 		PF00464
(SHMT) 		5 ALA A 103
SER A 102
ALA A  96
GLY A 237
SER A  98
 None
 1.15A 6bklE-5vmbA:
undetectable
6bklF-5vmbA:
undetectable
6bklG-5vmbA:
undetectable
6bklH-5vmbA:
undetectable		 6bklE-5vmbA:
4.24
6bklF-5vmbA:
4.24
6bklG-5vmbA:
4.24
6bklH-5vmbA:
4.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xxu RIBOSOMAL PROTEIN
US2

(Toxoplasma
gondii) 		PF00318
(Ribosomal_S2) 		5 ALA A 101
SER A  85
GLY A  84
ALA A  99
SER A  92
 None
 1.21A 6bklE-5xxuA:
undetectable
6bklF-5xxuA:
undetectable
6bklG-5xxuA:
undetectable
6bklH-5xxuA:
undetectable		 6bklE-5xxuA:
8.22
6bklF-5xxuA:
8.22
6bklG-5xxuA:
8.22
6bklH-5xxuA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bwt THIOREDOXIN
REDUCTASE

(Francisella
tularensis) 		no annotation 5 ALA A 303
ALA A 110
GLY A 300
ALA A 286
GLY A 283
 None
SO4  A 402 ( 4.9A)
None
None
SO4  A 402 (-3.5A)
 1.17A 6bklE-6bwtA:
undetectable
6bklF-6bwtA:
undetectable
6bklG-6bwtA:
undetectable
6bklH-6bwtA:
undetectable		 6bklE-6bwtA:
undetectable
6bklF-6bwtA:
undetectable
6bklG-6bwtA:
undetectable
6bklH-6bwtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6cr0 (S)-6-HYDROXYNICOTIN
E OXIDASE

(Shinella sp.
HZN7) 		no annotation 5 ALA A 418
SER A  16
GLY A 422
ALA A 406
SER A 405
 FAD  A 507 (-3.4A)
FAD  A 507 (-2.7A)
None
None
FAD  A 507 (-2.9A)
 1.12A 6bklE-6cr0A:
undetectable
6bklF-6cr0A:
undetectable
6bklG-6cr0A:
undetectable
6bklH-6cr0A:
undetectable		 6bklE-6cr0A:
undetectable
6bklF-6cr0A:
undetectable
6bklG-6cr0A:
undetectable
6bklH-6cr0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6elc VARIANT SURFACE
GLYCOPROTEIN

(Trypanosoma
brucei) 		no annotation 5 ALA A 311
GLY A 313
ALA A 318
SER A 317
GLY A 316
 None
None
GLC  A 605 (-4.2A)
GLC  A 605 (-1.4A)
None
 1.17A 6bklE-6elcA:
undetectable
6bklF-6elcA:
undetectable
6bklG-6elcA:
undetectable
6bklH-6elcA:
undetectable		 6bklE-6elcA:
undetectable
6bklF-6elcA:
undetectable
6bklG-6elcA:
undetectable
6bklH-6elcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo sapiens) 		no annotation 5 ALA A 444
SER A 443
ALA A 520
SER A 521
SER A 440
 None
 0.86A 6bklE-6etiA:
undetectable
6bklF-6etiA:
undetectable
6bklG-6etiA:
undetectable
6bklH-6etiA:
undetectable		 6bklE-6etiA:
undetectable
6bklF-6etiA:
undetectable
6bklG-6etiA:
undetectable
6bklH-6etiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6eti ATP-BINDING CASSETTE
SUB-FAMILY G MEMBER
2

(Homo sapiens) 		no annotation 5 SER A 440
ALA A 444
SER A 443
ALA A 520
SER A 521
 None
 0.91A 6bklE-6etiA:
undetectable
6bklF-6etiA:
undetectable
6bklG-6etiA:
undetectable
6bklH-6etiA:
undetectable		 6bklE-6etiA:
undetectable
6bklF-6etiA:
undetectable
6bklG-6etiA:
undetectable
6bklH-6etiA:
undetectable