SIMILAR PATTERNS OF AMINO ACIDS FOR 6BER_A_DVAA2

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1cpt CYTOCHROME P450-TERP

(Pseudomonas sp.) 		PF00067
(p450) 		3 GLU A 174
ASP A 176
PRO A 178
 None
 0.75A 6berA-1cptA:
undetectable		 6berA-1cptA:
3.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1d6h CHALCONE SYNTHASE

(Medicago sativa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		3 GLU A 179
ASP A 227
PRO A 228
 None
 0.33A 6berA-1d6hA:
undetectable		 6berA-1d6hA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ece ENDOCELLULASE E1

(Acidothermus
cellulolyticus) 		PF00150
(Cellulase) 		3 GLU A 183
ASP A 177
PRO A 174
 None
 0.73A 6berA-1eceA:
undetectable		 6berA-1eceA:
3.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1f82 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27) 		3 GLU A 267
ASP A 275
PRO A 276
 ZN  A 500 (-2.1A)
None
None
 0.68A 6berA-1f82A:
undetectable		 6berA-1f82A:
15.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1fcu HYALURONOGLUCOSAMINI
DASE

(Apis mellifera) 		PF01630
(Glyco_hydro_56) 		3 GLU A  49
ASP A 101
PRO A 100
 None
 0.68A 6berA-1fcuA:
undetectable		 6berA-1fcuA:
5.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1h09 LYSOZYME

(Streptococcus
virus Cp1) 		PF01183
(Glyco_hydro_25)
PF01473
(CW_binding_1) 		3 GLU A  94
ASP A  96
PRO A  97
 None
 0.70A 6berA-1h09A:
undetectable		 6berA-1h09A:
6.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1idu VANADIUM
CHLOROPEROXIDASE

(Curvularia
inaequalis) 		PF01569
(PAP2) 		3 GLU A 355
ASP A 243
PRO A 244
 None
 0.76A 6berA-1iduA:
undetectable		 6berA-1iduA:
1.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kp2 ARGININOSUCCINATE
SYNTHETASE

(Escherichia
coli) 		PF00764
(Arginosuc_synth) 		3 GLU A 164
ASP A 158
PRO A 155
 None
 0.45A 6berA-1kp2A:
undetectable		 6berA-1kp2A:
3.66
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1l1j HEAT SHOCK PROTEASE
HTRA

(Thermotoga
maritima) 		PF13365
(Trypsin_2) 		3 GLU A 144
ASP A  87
PRO A  88
 None
 0.64A 6berA-1l1jA:
undetectable		 6berA-1l1jA:
40.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lfw PEPV

(Lactobacillus
delbrueckii) 		PF01546
(Peptidase_M20) 		3 GLU A 422
ASP A 389
PRO A 386
 None
 0.75A 6berA-1lfwA:
undetectable		 6berA-1lfwA:
6.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lwh 4-ALPHA-GLUCANOTRANS
FERASE

(Thermotoga
maritima) 		PF00128
(Alpha-amylase)
PF09178
(DUF1945) 		3 GLU A 328
ASP A 332
PRO A 333
 None
 0.80A 6berA-1lwhA:
undetectable		 6berA-1lwhA:
3.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1mio NITROGENASE
MOLYBDENUM IRON
PROTEIN (BETA CHAIN)

(Clostridium
pasteurianum) 		PF00148
(Oxidored_nitro) 		3 GLU B 371
ASP B 373
PRO B  19
 None
 0.68A 6berA-1mioB:
undetectable		 6berA-1mioB:
4.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1nvj MOLYBDOPTERIN
CONVERTING FACTOR
SUBUNIT 2

(Escherichia
coli) 		PF02391
(MoaE) 		3 GLU A  87
ASP A  92
PRO A  90
 None
 0.73A 6berA-1nvjA:
undetectable		 6berA-1nvjA:
7.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o6b PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Bacillus
subtilis) 		PF01467
(CTP_transf_like) 		3 GLU A  50
ASP A  12
PRO A  13
 None
 0.74A 6berA-1o6bA:
undetectable		 6berA-1o6bA:
6.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1od6 PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Thermus
thermophilus) 		PF01467
(CTP_transf_like) 		3 GLU A  50
ASP A  10
PRO A  11
 None
 0.76A 6berA-1od6A:
undetectable		 6berA-1od6A:
7.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1p2z HEXON PROTEIN

(Human
mastadenovirus
C) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		3 GLU A 921
ASP A 923
PRO A 924
 None
 0.78A 6berA-1p2zA:
undetectable		 6berA-1p2zA:
1.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q0v HYDROPHILIC PROTEIN
HAS CYSTEINE RICH
PUTATIVE ZINC FINGER
ESSENTIAL FOR
FUNCTION
VPS27P

(Saccharomyces
cerevisiae) 		PF02809
(UIM) 		3 GLU A 301
ASP A 303
PRO A 304
 None
 0.69A 6berA-1q0vA:
undetectable		 6berA-1q0vA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qjc PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Escherichia
coli) 		PF01467
(CTP_transf_like) 		3 GLU A  50
ASP A  12
PRO A  13
 None
 0.80A 6berA-1qjcA:
undetectable		 6berA-1qjcA:
9.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qr4 PROTEIN (TENASCIN)

(Gallus gallus) 		PF00041
(fn3) 		3 GLU A   7
ASP A  10
PRO A  11
 None
 0.65A 6berA-1qr4A:
undetectable		 6berA-1qr4A:
5.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rz0 PHENOL 2-HYDROXYLASE
COMPONENT B

(Parageobacillus
thermoglucosidasius) 		PF01613
(Flavin_Reduct) 		3 GLU A 137
ASP A 139
PRO A 140
 None
 0.68A 6berA-1rz0A:
undetectable		 6berA-1rz0A:
16.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1t3q QUINOLINE
2-OXIDOREDUCTASE
LARGE SUBUNIT

(Pseudomonas
putida) 		PF01315
(Ald_Xan_dh_C)
PF02738
(Ald_Xan_dh_C2) 		3 GLU B 625
ASP B 492
PRO B 493
 None
 0.62A 6berA-1t3qB:
undetectable		 6berA-1t3qB:
2.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tz9 MANNONATE
DEHYDRATASE

(Enterococcus
faecalis) 		PF03786
(UxuA) 		3 GLU A 214
ASP A 209
PRO A 212
 None
 0.80A 6berA-1tz9A:
undetectable		 6berA-1tz9A:
2.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1u0u DIHYDROPINOSYLVIN
SYNTHASE

(Pinus
sylvestris) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		3 GLU A 182
ASP A 230
PRO A 231
 None
 0.49A 6berA-1u0uA:
undetectable		 6berA-1u0uA:
16.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ug8 POLY(A)-SPECIFIC
RIBONUCLEASE

(Mus musculus) 		PF01424
(R3H) 		3 GLU A  33
ASP A  35
PRO A  36
 None
 0.79A 6berA-1ug8A:
undetectable		 6berA-1ug8A:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v26 LONG-CHAIN-FATTY-ACI
D-COA SYNTHETASE

(Thermus
thermophilus) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		3 GLU A 167
ASP A 169
PRO A 170
 None
 0.64A 6berA-1v26A:
undetectable		 6berA-1v26A:
4.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1vlh PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Thermotoga
maritima) 		PF01467
(CTP_transf_like) 		3 GLU A  48
ASP A  10
PRO A  11
 None
 0.80A 6berA-1vlhA:
undetectable		 6berA-1vlhA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wiz DNA-BINDING PROTEIN
SATB2

(Homo sapiens) 		PF02376
(CUT) 		3 GLU A  59
ASP A  61
PRO A  62
 None
 0.67A 6berA-1wizA:
undetectable		 6berA-1wizA:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1e STILBENE SYNTHASE

(Arachis
hypogaea) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		3 GLU A 179
ASP A 227
PRO A 228
 None
 0.35A 6berA-1z1eA:
undetectable		 6berA-1z1eA:
11.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2d52 PENTAKETIDE CHROMONE
SYNTHASE

(Aloe
arborescens) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		3 GLU A 192
ASP A 240
PRO A 241
 None
 0.39A 6berA-2d52A:
undetectable		 6berA-2d52A:
5.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ejv L-THREONINE
3-DEHYDROGENASE

(Thermus
thermophilus) 		PF00107
(ADH_zinc_N)
PF08240
(ADH_N) 		3 GLU A 123
ASP A 340
PRO A 318
 None
 0.67A 6berA-2ejvA:
undetectable		 6berA-2ejvA:
4.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fin RABBITPOX ENCODED CC
CHEMOKINE INHIBITOR

(Vaccinia virus) 		PF02250
(Orthopox_35kD) 		3 GLU A  63
ASP A  59
PRO A  58
 None
 0.78A 6berA-2finA:
undetectable		 6berA-2finA:
4.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2fuq HEPARINASE II
PROTEIN

(Pedobacter
heparinus) 		PF07940
(Hepar_II_III)
PF16332
(DUF4962) 		3 GLU A 651
ASP A 638
PRO A 639
 None
 0.78A 6berA-2fuqA:
undetectable		 6berA-2fuqA:
2.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h1t HYPOTHETICAL PROTEIN

(Pseudomonas
aeruginosa) 		PF06475
(Glycolipid_bind) 		3 GLU A 134
ASP A  38
PRO A  37
 None
 0.75A 6berA-2h1tA:
undetectable		 6berA-2h1tA:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2i6h HYPOTHETICAL PROTEIN
ATU0120

(Agrobacterium
fabrum) 		PF06041
(DUF924) 		3 GLU A 121
ASP A  86
PRO A  87
 None
 0.52A 6berA-2i6hA:
undetectable		 6berA-2i6hA:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ifg HIGH AFFINITY NERVE
GROWTH FACTOR
RECEPTOR

(Homo sapiens) 		PF13855
(LRR_8)
PF16920
(TPKR_C2) 		3 GLU A  83
ASP A 109
PRO A 108
 None
 0.76A 6berA-2ifgA:
undetectable		 6berA-2ifgA:
2.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2k6m SUPERVILLIN

(Homo sapiens) 		PF02209
(VHP) 		3 GLU S  31
ASP S  34
PRO S  35
 None
 0.72A 6berA-2k6mS:
undetectable		 6berA-2k6mS:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2le9 ADVANCED
GLYCOSYLATION END
PRODUCT-SPECIFIC
RECEPTOR

(Homo sapiens) 		PF13895
(Ig_2) 		3 GLU A  60
ASP A  65
PRO A  63
 None
 0.76A 6berA-2le9A:
undetectable		 6berA-2le9A:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2np0 BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07951
(Toxin_R_bind_C)
PF07952
(Toxin_trans)
PF07953
(Toxin_R_bind_N) 		3 GLU A 267
ASP A 275
PRO A 276
 ZN  A1291 (-2.3A)
None
None
 0.76A 6berA-2np0A:
undetectable		 6berA-2np0A:
3.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2obe HEXON

(Human
mastadenovirus
E) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		3 GLU A 886
ASP A 888
PRO A 889
 None
 0.70A 6berA-2obeA:
undetectable		 6berA-2obeA:
2.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2otp LEUKOCYTE
IMMUNOGLOBULIN-LIKE
RECEPTOR SUBFAMILY A
MEMBER 2

(Homo sapiens) 		PF13895
(Ig_2) 		3 GLU A  84
ASP A  87
PRO A  88
 None
 0.65A 6berA-2otpA:
undetectable		 6berA-2otpA:
5.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2oxt NUCLEOSIDE-2'-O-METH
YLTRANSFERASE

(Meaban virus) 		PF01728
(FtsJ) 		3 GLU A  40
ASP A  37
PRO A 256
 None
 0.75A 6berA-2oxtA:
undetectable		 6berA-2oxtA:
5.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p0u STILBENECARBOXYLATE
SYNTHASE 2

(Marchantia
polymorpha) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		3 GLU A 197
ASP A 245
PRO A 246
 None
 0.28A 6berA-2p0uA:
undetectable		 6berA-2p0uA:
6.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pok PEPTIDASE,
M20/M25/M40 FAMILY

(Streptococcus
pneumoniae) 		PF01546
(Peptidase_M20)
PF07687
(M20_dimer) 		3 GLU A 257
ASP A 302
PRO A 303
 None
 0.77A 6berA-2pokA:
undetectable		 6berA-2pokA:
2.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qjl UBIQUITIN-RELATED
MODIFIER 1

(Saccharomyces
cerevisiae) 		PF09138
(Urm1) 		3 GLU A  85
ASP A  30
PRO A  31
 MG  A1002 ( 4.3A)
None
None
 0.80A 6berA-2qjlA:
undetectable		 6berA-2qjlA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qop HTH-TYPE
TRANSCRIPTIONAL
REGULATOR ACRR

(Escherichia
coli) 		PF00440
(TetR_N)
PF08361
(TetR_C_2) 		3 GLU A  91
ASP A  84
PRO A  82
 None
 0.78A 6berA-2qopA:
undetectable		 6berA-2qopA:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2wcv L-FUCOSE MUTAROTASE

(Escherichia
coli) 		PF05025
(RbsD_FucU) 		3 GLU A  62
ASP A  64
PRO A  69
 None
 0.76A 6berA-2wcvA:
undetectable		 6berA-2wcvA:
6.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ww9 SEC SIXTY-ONE
PROTEIN HOMOLOG

(Saccharomyces
cerevisiae) 		PF00344
(SecY)
PF10559
(Plug_translocon) 		3 GLU A  25
ASP A  31
PRO A  28
 None
 0.79A 6berA-2ww9A:
undetectable		 6berA-2ww9A:
2.99
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ywi HYPOTHETICAL
CONSERVED PROTEIN

(Geobacillus
kaustophilus) 		PF00578
(AhpC-TSA) 		3 GLU A  12
ASP A 131
PRO A 130
 None
 0.78A 6berA-2ywiA:
undetectable		 6berA-2ywiA:
8.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yys PROLINE
IMINOPEPTIDASE-RELAT
ED PROTEIN

(Thermus
thermophilus) 		PF12697
(Abhydrolase_6) 		3 GLU A 156
ASP A 149
PRO A 148
 None
 0.78A 6berA-2yysA:
undetectable		 6berA-2yysA:
6.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3awk CHALCONE
SYNTHASE-LIKE
POLYKETIDE SYNTHASE

(Huperzia
serrata) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		3 GLU A 189
ASP A 237
PRO A 238
 None
 0.30A 6berA-3awkA:
undetectable		 6berA-3awkA:
3.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b5h CERVICAL EMMPRIN

(Homo sapiens) 		PF13927
(Ig_3) 		3 GLU A 118
ASP A 179
PRO A 180
 None
 0.59A 6berA-3b5hA:
undetectable		 6berA-3b5hA:
8.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dsm UNCHARACTERIZED
PROTEIN BACUNI_02894

(Bacteroides
uniformis) 		no annotation 3 GLU A 215
ASP A 204
PRO A 241
 None
 0.63A 6berA-3dsmA:
undetectable		 6berA-3dsmA:
5.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3eqn GLUCAN
1,3-BETA-GLUCOSIDASE

(Phanerochaete
chrysosporium) 		PF12708
(Pectate_lyase_3) 		3 GLU A 485
ASP A 509
PRO A 510
 None
 0.75A 6berA-3eqnA:
undetectable		 6berA-3eqnA:
1.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3f0c TRANSCRIPTIONAL
REGULATOR

(Cytophaga
hutchinsonii) 		PF00440
(TetR_N) 		3 GLU A  60
ASP A  54
PRO A  53
 None
 0.64A 6berA-3f0cA:
undetectable		 6berA-3f0cA:
8.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fka UNCHARACTERIZED
NTF-2 LIKE PROTEIN

(Ruegeria
pomeroyi) 		PF12893
(Lumazine_bd_2) 		3 GLU A  66
ASP A  68
PRO A  69
 None
 0.80A 6berA-3fkaA:
undetectable		 6berA-3fkaA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3g25 GLYCEROL KINASE

(Staphylococcus
aureus) 		PF00370
(FGGY_N)
PF02782
(FGGY_C) 		3 GLU A 430
ASP A 470
PRO A 471
 None
 0.66A 6berA-3g25A:
undetectable		 6berA-3g25A:
3.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gdo UNCHARACTERIZED
OXIDOREDUCTASE YVAA

(Bacillus
subtilis) 		PF01408
(GFO_IDH_MocA)
PF02894
(GFO_IDH_MocA_C) 		3 GLU A 275
ASP A  34
PRO A  31
 None
 0.53A 6berA-3gdoA:
undetectable		 6berA-3gdoA:
5.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gf5 MAJOR VAULT PROTEIN

(Mus musculus) 		PF01505
(Vault) 		3 GLU A 317
ASP A 286
PRO A 287
 None
 0.58A 6berA-3gf5A:
undetectable		 6berA-3gf5A:
3.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3gzs UNCHARACTERIZED SUSD
SUPERFAMILY PROTEIN

(Bacteroides
fragilis) 		PF12741
(SusD-like) 		3 GLU A 351
ASP A 353
PRO A 354
 None
 0.78A 6berA-3gzsA:
undetectable		 6berA-3gzsA:
4.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hkz DNA-DIRECTED RNA
POLYMERASE SUBUNIT
A'
DNA-DIRECTED RNA
POLYMERASE SUBUNIT B

(Sulfolobus
solfataricus;
Sulfolobus
solfataricus) 		PF00623
(RNA_pol_Rpb1_2)
PF04983
(RNA_pol_Rpb1_3)
PF04997
(RNA_pol_Rpb1_1)
PF04998
(RNA_pol_Rpb1_5)
PF05000
(RNA_pol_Rpb1_4)
PF00562
(RNA_pol_Rpb2_6)
PF04560
(RNA_pol_Rpb2_7)
PF04561
(RNA_pol_Rpb2_2)
PF04563
(RNA_pol_Rpb2_1)
PF04565
(RNA_pol_Rpb2_3)
PF04566
(RNA_pol_Rpb2_4)
PF04567
(RNA_pol_Rpb2_5) 		3 GLU B1103
ASP A 233
PRO A 221
 None
 0.70A 6berA-3hkzB:
undetectable		 6berA-3hkzB:
1.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ibg ATPASE, SUBUNIT OF
THE GET COMPLEX

(Aspergillus
fumigatus) 		PF02374
(ArsA_ATPase) 		3 GLU A  93
ASP A  95
PRO A  96
 None
 0.68A 6berA-3ibgA:
undetectable		 6berA-3ibgA:
6.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iyl VP1

(Aquareovirus C) 		PF06016
(Reovirus_L2) 		3 GLU W 343
ASP W 345
PRO W 346
 None
 0.65A 6berA-3iylW:
undetectable		 6berA-3iylW:
0.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3j3i CAPSID PROTEIN

(Penicillium
chrysogenum
virus) 		no annotation 3 GLU A 662
ASP A 717
PRO A 718
 None
 0.60A 6berA-3j3iA:
undetectable		 6berA-3j3iA:
1.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ksw STEROL 14-ALPHA
DEMETHYLASE

(Trypanosoma
cruzi) 		PF00067
(p450) 		3 GLU A 348
ASP A 353
PRO A 354
 None
 0.65A 6berA-3kswA:
undetectable		 6berA-3kswA:
1.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l4d STEROL 14-ALPHA
DEMETHYLASE

(Leishmania
infantum) 		PF00067
(p450) 		3 GLU A 347
ASP A 352
PRO A 353
 None
 0.66A 6berA-3l4dA:
undetectable		 6berA-3l4dA:
2.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m4a PUTATIVE TYPE I
TOPOISOMERASE

(Deinococcus
radiodurans) 		PF01028
(Topoisom_I) 		3 GLU A  61
ASP A  82
PRO A  81
 None
 0.78A 6berA-3m4aA:
undetectable		 6berA-3m4aA:
3.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m6m RPFF PROTEIN

(Xanthomonas
campestris) 		PF00378
(ECH_1) 		3 GLU A  20
ASP A  25
PRO A  71
 None
 0.73A 6berA-3m6mA:
undetectable		 6berA-3m6mA:
3.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3nzq BIOSYNTHETIC
ARGININE
DECARBOXYLASE

(Escherichia
coli) 		PF02784
(Orn_Arg_deC_N) 		3 GLU A 596
ASP A 592
PRO A 591
 None
 0.65A 6berA-3nzqA:
undetectable		 6berA-3nzqA:
2.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ov3 CURCUMIN SYNTHASE

(Curcuma longa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		3 GLU A 179
ASP A 227
PRO A 228
 None
 0.44A 6berA-3ov3A:
undetectable		 6berA-3ov3A:
3.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3p9u TETX2 PROTEIN

(Bacteroides
thetaiotaomicron) 		PF01494
(FAD_binding_3) 		3 GLU A 374
ASP A 379
PRO A 378
 None
 0.68A 6berA-3p9uA:
undetectable		 6berA-3p9uA:
8.93
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3pis KAZAL-TYPE SERINE
PROTEASE INHIBITOR
SPI-1

(Carcinoscorpius
rotundicauda) 		no annotation 3 GLU D  15
ASP D  18
PRO D   8
 None
 0.77A 6berA-3pisD:
undetectable		 6berA-3pisD:
43.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psf TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		3 GLU A1038
ASP A1040
PRO A1041
 None
 0.72A 6berA-3psfA:
undetectable		 6berA-3psfA:
2.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3psi TRANSCRIPTION
ELONGATION FACTOR
SPT6

(Saccharomyces
cerevisiae) 		PF14635
(HHH_7)
PF14639
(YqgF)
PF14641
(HTH_44)
PF14878
(DLD) 		3 GLU A1038
ASP A1040
PRO A1041
 None
 0.58A 6berA-3psiA:
undetectable		 6berA-3psiA:
2.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pxu PHOSPHOPANTETHEINE
ADENYLYLTRANSFERASE

(Burkholderia
pseudomallei) 		PF01467
(CTP_transf_like) 		3 GLU A  49
ASP A  11
PRO A  12
 None
 0.80A 6berA-3pxuA:
undetectable		 6berA-3pxuA:
10.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rns CUPIN 2 CONSERVED
BARREL DOMAIN
PROTEIN

(Leptotrichia
buccalis) 		PF07883
(Cupin_2) 		3 GLU A 209
ASP A 164
PRO A 165
 None
 0.71A 6berA-3rnsA:
undetectable		 6berA-3rnsA:
5.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3shp PUTATIVE
ACETYLTRANSFERASE
STHE_0691

(Sphaerobacter
thermophilus) 		no annotation 3 GLU A  45
ASP A  50
PRO A  51
 None
 0.80A 6berA-3shpA:
undetectable		 6berA-3shpA:
20.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tsy FUSION PROTEIN
4-COUMARATE--COA
LIGASE 1,
RESVERATROL SYNTHASE

(Arabidopsis
thaliana;
Vitis vinifera) 		PF00195
(Chal_sti_synt_N)
PF00501
(AMP-binding)
PF02797
(Chal_sti_synt_C)
PF13193
(AMP-binding_C) 		3 GLU A 766
ASP A 814
PRO A 815
 None
 0.36A 6berA-3tsyA:
undetectable		 6berA-3tsyA:
1.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tw8 RAS-RELATED PROTEIN
RAB-35

(Homo sapiens) 		PF00071
(Ras) 		3 GLU B 153
ASP B 124
PRO B 125
 None
 0.48A 6berA-3tw8B:
undetectable		 6berA-3tw8B:
5.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tzt GLYCOSYL TRANSFERASE
FAMILY 8

(Anaerococcus
prevotii) 		PF01501
(Glyco_transf_8) 		3 GLU A 168
ASP A 171
PRO A 172
 None
 0.76A 6berA-3tztA:
undetectable		 6berA-3tztA:
25.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3vil BETA-GLUCOSIDASE

(Neotermes
koshunensis) 		PF00232
(Glyco_hydro_1) 		3 GLU A 321
ASP A 291
PRO A 284
 None
 0.79A 6berA-3vilA:
undetectable		 6berA-3vilA:
5.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wd7 TYPE III POLYKETIDE
SYNTHASES ACRIDONE
SYNTHASE

(Citrus x
microcarpa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		3 GLU A 179
ASP A 227
PRO A 228
 GLU  A 179 ( 0.6A)
ASP  A 227 ( 0.6A)
PRO  A 228 ( 1.1A)
 0.31A 6berA-3wd7A:
undetectable		 6berA-3wd7A:
3.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wd8 TYPE III POLYKETIDE
SYNTHASE QUINOLONE
SYNTHASE

(Citrus x
microcarpa) 		PF00195
(Chal_sti_synt_N)
PF02797
(Chal_sti_synt_C) 		3 GLU A 179
ASP A 227
PRO A 228
 None
 0.51A 6berA-3wd8A:
undetectable		 6berA-3wd8A:
2.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfo POLY A POLYMERASE

(Aquifex
aeolicus) 		PF01743
(PolyA_pol)
PF01966
(HD)
PF12627
(PolyA_pol_RNAbd) 		3 GLU A 206
ASP A 211
PRO A 212
 None
 0.56A 6berA-3wfoA:
undetectable		 6berA-3wfoA:
2.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wfp POLY A POLYMERASE

(synthetic
construct;
Aquifex
aeolicus) 		PF01743
(PolyA_pol)
PF01966
(HD)
PF12627
(PolyA_pol_RNAbd) 		3 GLU A 206
ASP A 211
PRO A 212
 None
 0.77A 6berA-3wfpA:
undetectable		 6berA-3wfpA:
2.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3whl PROTEASOME-ACTIVATIN
G NUCLEOTIDASE, 26S
PROTEASE REGULATORY
SUBUNIT 6A

(Pyrococcus
furiosus;
Saccharomyces
cerevisiae) 		PF00004
(AAA) 		3 GLU A 208
ASP A 213
PRO A 214
 GLU  A 208 ( 0.6A)
ASP  A 213 ( 0.6A)
PRO  A 214 ( 1.1A)
 0.50A 6berA-3whlA:
undetectable		 6berA-3whlA:
6.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wq4 BETA-PRIMEVEROSIDASE

(Camellia
sinensis) 		PF00232
(Glyco_hydro_1) 		3 GLU A 405
ASP A 409
PRO A 410
 None
 0.78A 6berA-3wq4A:
undetectable		 6berA-3wq4A:
4.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zif HEXON PROTEIN

(Bovine
mastadenovirus
B) 		PF01065
(Adeno_hexon)
PF03678
(Adeno_hexon_C) 		3 GLU A 865
ASP A 867
PRO A 868
 None
 0.71A 6berA-3zifA:
undetectable		 6berA-3zifA:
1.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpj TON_1535

(Thermococcus
onnurineus) 		no annotation 3 GLU A 314
ASP A 341
PRO A 340
 None
 0.65A 6berA-3zpjA:
undetectable		 6berA-3zpjA:
3.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zuq BOTULINUM NEUROTOXIN
TYPE B

(Clostridium
botulinum) 		PF01742
(Peptidase_M27)
PF07952
(Toxin_trans) 		3 GLU A 268
ASP A 276
PRO A 277
 ZN  A1440 (-2.1A)
None
None
 0.48A 6berA-3zuqA:
undetectable		 6berA-3zuqA:
1.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bed HEMOCYANIN KLH1

(Megathura
crenulata) 		PF00264
(Tyrosinase)
PF14830
(Haemocyan_bet_s) 		3 GLU A 954
ASP A 948
PRO A 949
 None
 0.78A 6berA-4bedA:
undetectable		 6berA-4bedA:
0.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bmb GALECTIN-8

(Homo sapiens) 		PF00337
(Gal-bind_lectin) 		3 GLU A 133
ASP A  28
PRO A  29
 None
 0.74A 6berA-4bmbA:
undetectable		 6berA-4bmbA:
10.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bwc PHOSPHOLIPASE B-LIKE
1
PHOSPHOLIPASE B-LIKE
1

(Bos taurus;
Bos taurus) 		PF04916
(Phospholip_B)
PF04916
(Phospholip_B) 		3 GLU B 528
ASP A 112
PRO A 109
 None
 0.70A 6berA-4bwcB:
undetectable		 6berA-4bwcB:
4.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cr4 26S PROTEASE
REGULATORY SUBUNIT
6B HOMOLOG

(Saccharomyces
cerevisiae) 		PF00004
(AAA) 		3 GLU K 199
ASP K 204
PRO K 205
 None
 0.38A 6berA-4cr4K:
undetectable		 6berA-4cr4K:
4.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ewl 1D-MYO-INOSITOL
2-ACETAMIDO-2-DEOXY-
ALPHA-D-GLUCOPYRANOS
IDE DEACETYLASE

(Mycobacterium
tuberculosis) 		PF02585
(PIG-L) 		3 GLU A  45
ASP A 146
PRO A 145
 None
 0.72A 6berA-4ewlA:
undetectable		 6berA-4ewlA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fwv TTC1975 PEPTIDASE

(Meiothermus
taiwanensis) 		PF13654
(AAA_32) 		3 GLU A 320
ASP A 313
PRO A 270
 None
SO4  A 401 ( 4.9A)
None
 0.74A 6berA-4fwvA:
undetectable		 6berA-4fwvA:
3.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g3j STEROL
14-ALPHA-DEMETHYLASE

(Trypanosoma
brucei) 		PF00067
(p450) 		3 GLU A 348
ASP A 353
PRO A 354
 None
 0.57A 6berA-4g3jA:
undetectable		 6berA-4g3jA:
2.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ha7 2,5-DIAMINO-6-RIBOSY
LAMINO-4(3H)-PYRIMID
INONE 5'-PHOSPHATE
REDUCTASE

(Saccharomyces
cerevisiae) 		PF01872
(RibD_C) 		3 GLU A 166
ASP A 160
PRO A 151
 None
 0.74A 6berA-4ha7A:
undetectable		 6berA-4ha7A:
7.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4o1j CARBONIC ANHYDRASE

(Sordaria
macrospora) 		PF00484
(Pro_CA) 		3 GLU A  52
ASP A  62
PRO A  38
 None
 0.60A 6berA-4o1jA:
undetectable		 6berA-4o1jA:
12.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ppm AMINOTRANSFERASE

(Serratia sp.
FS14) 		PF00202
(Aminotran_3) 		3 GLU A 570
ASP A 564
PRO A 561
 None
 0.73A 6berA-4ppmA:
undetectable		 6berA-4ppmA:
2.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pri TK3 TCR BETA CHAIN

(Homo sapiens) 		PF07654
(C1-set)
PF07686
(V-set) 		3 GLU E  88
ASP E  84
PRO E  83
 None
 0.78A 6berA-4priE:
undetectable		 6berA-4priE:
6.61