SIMILAR PATTERNS OF AMINO ACIDS FOR 6BEO_A_DHIA4

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1air PECTATE LYASE C

(Dickeya
chrysanthemi) 		PF00544
(Pec_lyase_C) 		3 TYR A 184
PRO A 335
LEU A 334
 None
 0.86A 6beoA-1airA:
undetectable		 6beoA-1airA:
4.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e2z CYTOCHROME F

(Chlamydomonas
reinhardtii) 		PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N) 		3 TYR A 149
PRO A  78
LEU A  77
 None
 0.88A 6beoA-1e2zA:
undetectable		 6beoA-1e2zA:
3.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1j3d HIGH MOBILITY GROUP
PROTEIN 2

(Sus scrofa) 		PF00505
(HMG_box) 		3 TYR A  68
PRO A  12
LEU A  64
 None
 0.80A 6beoA-1j3dA:
undetectable		 6beoA-1j3dA:
15.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jdz 5'-METHYLTHIOADENOSI
NE PHOSPHORYLASE

(Sulfolobus
solfataricus) 		PF01048
(PNP_UDP_1) 		3 TYR A  48
PRO A  36
LEU A  33
 None
 0.91A 6beoA-1jdzA:
undetectable		 6beoA-1jdzA:
5.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k12 LECTIN

(Anguilla
anguilla) 		PF00754
(F5_F8_type_C) 		3 TYR A 136
PRO A  59
LEU A 143
 None
 0.81A 6beoA-1k12A:
undetectable		 6beoA-1k12A:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k72 ENDOGLUCANASE 9G

([Clostridium]
cellulolyticum) 		PF00759
(Glyco_hydro_9)
PF00942
(CBM_3) 		3 TYR A  68
PRO A  65
LEU A  64
 None
 0.95A 6beoA-1k72A:
undetectable		 6beoA-1k72A:
4.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1k7j PROTEIN YCIO

(Escherichia
coli) 		PF01300
(Sua5_yciO_yrdC) 		3 TYR A  78
PRO A 108
LEU A 111
 None
 0.92A 6beoA-1k7jA:
undetectable		 6beoA-1k7jA:
3.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kdu PLASMINOGEN
ACTIVATOR

(Homo sapiens) 		PF00051
(Kringle) 		3 TYR A  50
PRO A  24
LEU A  23
 None
 0.92A 6beoA-1kduA:
undetectable		 6beoA-1kduA:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kfu M-CALPAIN LARGE
SUBUNIT

(Homo sapiens) 		PF00648
(Peptidase_C2)
PF01067
(Calpain_III)
PF13833
(EF-hand_8) 		3 TYR L 215
PRO L 220
LEU L 217
 None
 0.93A 6beoA-1kfuL:
undetectable		 6beoA-1kfuL:
4.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1o99 2,3-BISPHOSPHOGLYCER
ATE-INDEPENDENT
PHOSPHOGLYCERATE
MUTASE

(Geobacillus
stearothermophilus) 		PF01676
(Metalloenzyme)
PF06415
(iPGM_N) 		3 TYR A  76
PRO A  55
LEU A  54
 None
 0.90A 6beoA-1o99A:
undetectable		 6beoA-1o99A:
2.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1q90 APOCYTOCHROME F

(Chlamydomonas
reinhardtii) 		PF01333
(Apocytochr_F_C)
PF16639
(Apocytochr_F_N) 		3 TYR A 149
PRO A  78
LEU A  77
 None
 0.89A 6beoA-1q90A:
undetectable		 6beoA-1q90A:
3.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1qz9 KYNURENINASE

(Pseudomonas
fluorescens) 		PF00266
(Aminotran_5) 		3 TYR A 278
PRO A 252
LEU A 253
 None
 0.88A 6beoA-1qz9A:
undetectable		 6beoA-1qz9A:
12.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r2j PROTEIN FKBI

(Streptomyces
hygroscopicus) 		PF00441
(Acyl-CoA_dh_1)
PF02770
(Acyl-CoA_dh_M)
PF02771
(Acyl-CoA_dh_N) 		3 TYR A 148
PRO A  26
LEU A  29
 None
 0.94A 6beoA-1r2jA:
undetectable		 6beoA-1r2jA:
3.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1r6v SUBTILISIN-LIKE
SERINE PROTEASE

(Fervidobacterium
pennivorans) 		PF00082
(Peptidase_S8) 		3 TYR A 532
PRO A 529
LEU A 536
 None
 0.84A 6beoA-1r6vA:
undetectable		 6beoA-1r6vA:
1.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1tz7 4-ALPHA-GLUCANOTRANS
FERASE

(Aquifex
aeolicus) 		PF02446
(Glyco_hydro_77) 		3 TYR A 451
PRO A 387
LEU A 386
 None
 0.82A 6beoA-1tz7A:
undetectable		 6beoA-1tz7A:
4.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urx BETA-AGARASE A

(Zobellia
galactanivorans) 		PF00722
(Glyco_hydro_16) 		3 TYR A 106
PRO A  99
LEU A 268
 AAL  A1293 ( 3.9A)
None
None
 0.91A 6beoA-1urxA:
undetectable		 6beoA-1urxA:
3.65
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
1uw4 UPF3X

(Homo sapiens) 		PF03467
(Smg4_UPF3) 		3 TYR A  94
PRO A  59
LEU A  58
 None
 0.88A 6beoA-1uw4A:
undetectable		 6beoA-1uw4A:
50.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1v19 2-KETO-3-DEOXYGLUCON
ATE KINASE

(Thermus
thermophilus) 		PF00294
(PfkB) 		3 TYR A  93
PRO A  95
LEU A  94
 None
 0.84A 6beoA-1v19A:
undetectable		 6beoA-1v19A:
2.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1w8j MYOSIN VA

(Gallus gallus) 		PF00063
(Myosin_head) 		3 TYR A  79
PRO A  65
LEU A  68
 None
 0.67A 6beoA-1w8jA:
undetectable		 6beoA-1w8jA:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wl1 OCTOPRENYL-DIPHOSPHA
TE SYNTHASE

(Thermotoga
maritima) 		PF00348
(polyprenyl_synt) 		3 TYR A 159
PRO A 231
LEU A 232
 None
 0.84A 6beoA-1wl1A:
undetectable		 6beoA-1wl1A:
3.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1z1d LARGE T ANTIGEN

(Macaca mulatta
polyomavirus 1) 		PF02217
(T_Ag_DNA_bind) 		3 TYR B  34
PRO B  11
LEU B  14
 None
 0.88A 6beoA-1z1dB:
undetectable		 6beoA-1z1dB:
5.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1zcz BIFUNCTIONAL PURINE
BIOSYNTHESIS PROTEIN
PURH

(Thermotoga
maritima) 		PF01808
(AICARFT_IMPCHas)
PF02142
(MGS) 		3 TYR A 322
PRO A 215
LEU A 214
 None
 0.85A 6beoA-1zczA:
undetectable		 6beoA-1zczA:
7.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dcr PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE FES/FPS

(Homo sapiens) 		PF00017
(SH2) 		3 TYR A  71
PRO A  82
LEU A  83
 None
 0.85A 6beoA-2dcrA:
undetectable		 6beoA-2dcrA:
12.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dfs MYOSIN-5A

(Gallus gallus) 		PF00063
(Myosin_head)
PF00612
(IQ) 		3 TYR A  79
PRO A  65
LEU A  68
 None
 0.76A 6beoA-2dfsA:
undetectable		 6beoA-2dfsA:
0.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dpp NITRILE HYDRATASE
ALPHA SUBUNIT

(Bacillus sp.
RAPc8) 		PF02979
(NHase_alpha) 		3 TYR A 134
PRO A 123
LEU A 127
 CSO  A 121 ( 4.5A)
None
None
 0.88A 6beoA-2dppA:
undetectable		 6beoA-2dppA:
4.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2dxb THIOCYANATE
HYDROLASE SUBUNIT
GAMMA

(Thiobacillus
thioparus) 		PF02979
(NHase_alpha) 		3 TYR C 146
PRO C 135
LEU C 139
 CSO  C 133 ( 4.5A)
None
None
 0.73A 6beoA-2dxbC:
undetectable		 6beoA-2dxbC:
6.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2f9i ACETYL-COENZYME A
CARBOXYLASE CARBOXYL
TRANSFERASE SUBUNIT
BETA

(Staphylococcus
aureus) 		PF01039
(Carboxyl_trans) 		3 TYR B  94
PRO B  88
LEU B  89
 None
 0.93A 6beoA-2f9iB:
undetectable		 6beoA-2f9iB:
4.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2h0r NICOTINAMIDASE

(Saccharomyces
cerevisiae) 		PF00857
(Isochorismatase) 		3 TYR A 166
PRO A 191
LEU A 164
 None
 0.93A 6beoA-2h0rA:
undetectable		 6beoA-2h0rA:
9.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2heq YORP PROTEIN

(Bacillus
subtilis) 		PF09629
(YorP) 		3 TYR A  49
PRO A  13
LEU A  16
 None
 0.88A 6beoA-2heqA:
undetectable		 6beoA-2heqA:
36.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2muk AUXIN-RESPONSIVE
PROTEIN IAA17

(Arabidopsis
thaliana) 		PF02309
(AUX_IAA) 		3 TYR X 181
PRO X 179
LEU X 208
 None
 0.51A 6beoA-2mukX:
undetectable		 6beoA-2mukX:
26.09
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2o5h HYPOTHETICAL PROTEIN

(Neisseria
meningitidis) 		PF04591
(DUF596) 		3 TYR A 130
PRO A  30
LEU A  29
 None
 0.93A 6beoA-2o5hA:
undetectable		 6beoA-2o5hA:
38.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pb9 PHOSPHOMETHYLPYRIMID
INE KINASE

(Pyrococcus
furiosus) 		PF10120
(ThiP_synth) 		3 TYR A 301
PRO A 304
LEU A 303
 None
 0.73A 6beoA-2pb9A:
undetectable		 6beoA-2pb9A:
4.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2r9g AAA ATPASE, CENTRAL
REGION

(Enterococcus
faecium) 		PF12002
(MgsA_C) 		3 TYR A 284
PRO A 292
LEU A 289
 None
 0.79A 6beoA-2r9gA:
undetectable		 6beoA-2r9gA:
7.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2vow SURFACE-ASSOCIATED
PROTEIN

(Methylococcus
capsulatus) 		no annotation 3 TYR A 104
PRO A 106
LEU A 313
 None
 0.81A 6beoA-2vowA:
undetectable		 6beoA-2vowA:
5.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfb E2 ENVELOPE
GLYCOPROTEIN

(Chikungunya
virus) 		PF00943
(Alpha_E2_glycop) 		3 TYR B 301
PRO B 304
LEU B 305
 None
 0.94A 6beoA-2xfbB:
undetectable		 6beoA-2xfbB:
2.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2xfc E2 ENVELOPE
GLYCOPROTEIN

(Chikungunya
virus) 		PF00943
(Alpha_E2_glycop) 		3 TYR B 301
PRO B 304
LEU B 305
 None
 0.93A 6beoA-2xfcB:
undetectable		 6beoA-2xfcB:
4.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2xmo LMO2642 PROTEIN

(Listeria
monocytogenes) 		PF00149
(Metallophos) 		3 TYR A 165
PRO A 132
LEU A 181
 None
 0.61A 6beoA-2xmoA:
undetectable		 6beoA-2xmoA:
31.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y6e UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 4

(Homo sapiens) 		PF00443
(UCH) 		3 TYR A 863
PRO A 818
LEU A 821
 None
 0.77A 6beoA-2y6eA:
undetectable		 6beoA-2y6eA:
2.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT

(Clostridium
scatologenes) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		3 TYR A 415
PRO A 513
LEU A 512
 None
 0.88A 6beoA-2y8nA:
undetectable		 6beoA-2y8nA:
1.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2y8n 4-HYDROXYPHENYLACETA
TE DECARBOXYLASE
LARGE SUBUNIT

(Clostridium
scatologenes) 		PF01228
(Gly_radical)
PF02901
(PFL-like) 		3 TYR A 468
PRO A 440
LEU A 408
 None
 0.74A 6beoA-2y8nA:
undetectable		 6beoA-2y8nA:
1.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ysx SIGNALING INOSITOL
POLYPHOSPHATE
PHOSPHATASE SHIP II

(Homo sapiens) 		PF00017
(SH2) 		3 TYR A  47
PRO A  64
LEU A  63
 None
 0.86A 6beoA-2ysxA:
undetectable		 6beoA-2ysxA:
5.71
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2yxz THIAMIN-MONOPHOSPHAT
E KINASE

(Thermus
thermophilus) 		PF00586
(AIRS)
PF02769
(AIRS_C) 		3 TYR A 137
PRO A  83
LEU A  76
 None
 0.93A 6beoA-2yxzA:
undetectable		 6beoA-2yxzA:
3.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cqf THIOL-ACTIVATED
CYTOLYSIN

(Bacillus
anthracis) 		PF01289
(Thiol_cytolysin)
PF17440
(Thiol_cytolys_C) 		3 TYR A 116
PRO A 162
LEU A 142
 None
 0.72A 6beoA-3cqfA:
undetectable		 6beoA-3cqfA:
2.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3d31 SULFATE/MOLYBDATE
ABC TRANSPORTER,
ATP-BINDING PROTEIN

(Methanosarcina
acetivorans) 		PF00005
(ABC_tran)
PF03459
(TOBE) 		3 TYR A  81
PRO A 154
LEU A 151
 None
 0.94A 6beoA-3d31A:
undetectable		 6beoA-3d31A:
3.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3dzc UDP-N-ACETYLGLUCOSAM
INE 2-EPIMERASE

(Vibrio cholerae) 		PF02350
(Epimerase_2) 		3 TYR A 279
PRO A 276
LEU A 275
 None
 0.93A 6beoA-3dzcA:
undetectable		 6beoA-3dzcA:
4.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3egw RESPIRATORY NITRATE
REDUCTASE 1 BETA
CHAIN

(Escherichia
coli) 		PF13247
(Fer4_11)
PF14711
(Nitr_red_bet_C) 		3 TYR B 347
PRO B 345
LEU B 292
 None
 0.91A 6beoA-3egwB:
undetectable		 6beoA-3egwB:
2.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ihp UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 5

(Homo sapiens) 		PF00443
(UCH)
PF00627
(UBA)
PF02148
(zf-UBP) 		3 TYR A 828
PRO A 594
LEU A 597
 None
 0.86A 6beoA-3ihpA:
undetectable		 6beoA-3ihpA:
1.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ir1 OUTER MEMBRANE
LIPOPROTEIN GNA1946

(Neisseria
meningitidis) 		PF03180
(Lipoprotein_9) 		3 TYR A 129
PRO A 201
LEU A 200
 None
 0.95A 6beoA-3ir1A:
undetectable		 6beoA-3ir1A:
4.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3iy7 FRAGMENT FROM
NEUTRALIZING
ANTIBODY F (HEAVY
CHAIN)

(Rattus
norvegicus) 		PF07686
(V-set) 		3 TYR B 203
PRO B 201
LEU B 200
 None
 0.90A 6beoA-3iy7B:
undetectable		 6beoA-3iy7B:
14.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3lkz NON-STRUCTURAL
PROTEIN 5

(West Nile virus) 		PF01728
(FtsJ) 		3 TYR A 202
PRO A 176
LEU A 143
 None
 0.77A 6beoA-3lkzA:
undetectable		 6beoA-3lkzA:
3.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3n40 P62 ENVELOPE
GLYCOPROTEIN

(Chikungunya
virus) 		PF00943
(Alpha_E2_glycop)
PF01563
(Alpha_E3_glycop) 		3 TYR P 301
PRO P 304
LEU P 305
 None
 0.92A 6beoA-3n40P:
undetectable		 6beoA-3n40P:
2.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ndp ADENYLATE KINASE
ISOENZYME 4

(Homo sapiens) 		PF00406
(ADK)
PF05191
(ADK_lid) 		3 TYR A 136
PRO A 142
LEU A 138
 None
 0.93A 6beoA-3ndpA:
undetectable		 6beoA-3ndpA:
4.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3pe8 ENOYL-COA HYDRATASE

(Mycolicibacterium
smegmatis) 		PF00378
(ECH_1) 		3 TYR A 109
PRO A  85
LEU A  41
 None
 0.86A 6beoA-3pe8A:
undetectable		 6beoA-3pe8A:
2.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3poc ALPHA-GLUCOSIDASE

(Blautia obeum) 		PF01055
(Glyco_hydro_31)
PF13802
(Gal_mutarotas_2) 		3 TYR A 558
PRO A 556
LEU A 468
 None
 0.86A 6beoA-3pocA:
undetectable		 6beoA-3pocA:
1.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ppz SERINE/THREONINE-PRO
TEIN KINASE CTR1

(Arabidopsis
thaliana) 		PF07714
(Pkinase_Tyr) 		3 TYR A 656
PRO A 807
LEU A 808
 None
 0.95A 6beoA-3ppzA:
undetectable		 6beoA-3ppzA:
5.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qjg EPIDERMIN
BIOSYNTHESIS PROTEIN
EPID

(Staphylococcus
aureus) 		PF02441
(Flavoprotein) 		3 TYR A  21
PRO A  81
LEU A   9
 None
 0.81A 6beoA-3qjgA:
undetectable		 6beoA-3qjgA:
3.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qyr ECHA16_2

(Mycobacterium
avium) 		PF00378
(ECH_1) 		3 TYR A 108
PRO A  84
LEU A  40
 None
 0.86A 6beoA-3qyrA:
undetectable		 6beoA-3qyrA:
2.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3qz5 CO-TYPE NITRILE
HYDRATASE ALPHA
SUBUNIT

(Pseudomonas
putida) 		PF02979
(NHase_alpha) 		3 TYR A 130
PRO A 119
LEU A 123
 None
 0.84A 6beoA-3qz5A:
undetectable		 6beoA-3qz5A:
9.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3rpw ABC TRANSPORTER

(Rhodopseudomonas
palustris) 		PF13416
(SBP_bac_8) 		3 TYR A 237
PRO A 172
LEU A 235
 GOL  A 364 (-4.2A)
None
None
 0.91A 6beoA-3rpwA:
undetectable		 6beoA-3rpwA:
4.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3tk3 CYTOCHROME P450 2B4

(Oryctolagus
cuniculus) 		PF00067
(p450) 		3 TYR A  69
PRO A  38
LEU A  37
 None
 0.93A 6beoA-3tk3A:
undetectable		 6beoA-3tk3A:
1.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w40 PHOSPHOSERINE
PHOSPHATASE RSBX

(Bacillus
subtilis) 		PF07228
(SpoIIE) 		3 TYR A 123
PRO A 126
LEU A 125
 None
 0.91A 6beoA-3w40A:
undetectable		 6beoA-3w40A:
9.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3wic GLUCOSE
1-DEHYDROGENASE

(Thermoplasma
volcanium) 		PF08240
(ADH_N)
PF16912
(Glu_dehyd_C) 		3 TYR A  56
PRO A  58
LEU A  64
 None
 0.84A 6beoA-3wicA:
undetectable		 6beoA-3wicA:
2.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zpy ALGINATE LYASE,
FAMILY PL7

(Zobellia
galactanivorans) 		PF08787
(Alginate_lyase2) 		3 TYR A 228
PRO A 273
LEU A 264
 None
 0.82A 6beoA-3zpyA:
undetectable		 6beoA-3zpyA:
3.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4a2l TWO-COMPONENT SYSTEM
SENSOR HISTIDINE
KINASE/RESPONSE

(Bacteroides
thetaiotaomicron) 		PF07494
(Reg_prop)
PF07495
(Y_Y_Y) 		3 TYR A 577
PRO A 612
LEU A 599
 None
 0.91A 6beoA-4a2lA:
undetectable		 6beoA-4a2lA:
2.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ae5 SIGNAL TRANSDUCTION
PROTEIN TRAP

(Staphylococcus
aureus) 		no annotation 3 TYR A   8
PRO A  50
LEU A  47
 FMT  A1000 (-4.5A)
None
None
 0.71A 6beoA-4ae5A:
undetectable		 6beoA-4ae5A:
4.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b2n 70 KDA PROTEIN

(Xanthomonas sp.
35Y) 		no annotation 3 TYR A 152
PRO A 170
LEU A 173
 None
 0.91A 6beoA-4b2nA:
undetectable		 6beoA-4b2nA:
1.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4b7g CATALASE

(Corynebacterium
glutamicum) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 TYR A 388
PRO A 369
LEU A 368
 None
 0.84A 6beoA-4b7gA:
undetectable		 6beoA-4b7gA:
2.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bj4 AMPDH2

(Pseudomonas
aeruginosa) 		PF01471
(PG_binding_1)
PF01510
(Amidase_2) 		3 TYR A  43
PRO A 166
LEU A 167
 None
 0.92A 6beoA-4bj4A:
undetectable		 6beoA-4bj4A:
3.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cab CATALASE

(Deinococcus
radiodurans) 		PF00199
(Catalase)
PF06628
(Catalase-rel) 		3 TYR A 404
PRO A 385
LEU A 384
 None
 0.91A 6beoA-4cabA:
undetectable		 6beoA-4cabA:
1.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4doe 1,4-BETA-GLUCANASE

(Caldicellulosiruptor
bescii) 		PF00759
(Glyco_hydro_9) 		3 TYR A  90
PRO A  87
LEU A  86
 None
 0.93A 6beoA-4doeA:
undetectable		 6beoA-4doeA:
4.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4fys AMINOPEPTIDASE N

(Homo sapiens) 		PF01433
(Peptidase_M1)
PF11838
(ERAP1_C) 		3 TYR A 176
PRO A 148
LEU A 166
 None
 0.94A 6beoA-4fysA:
undetectable		 6beoA-4fysA:
3.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g6t TYPE III CHAPERONE
PROTEIN SHCA

(Pseudomonas
syringae group
genomosp. 3) 		PF05932
(CesT) 		3 TYR A  95
PRO A  81
LEU A 115
 None
 0.95A 6beoA-4g6tA:
undetectable		 6beoA-4g6tA:
8.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jjt ENOYL-COA HYDRATASE

(Mycobacterium
tuberculosis) 		PF00378
(ECH_1) 		3 TYR A 108
PRO A  84
LEU A  40
 None
 0.95A 6beoA-4jjtA:
undetectable		 6beoA-4jjtA:
6.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4k8l PROLINE RACEMASE

(Ochrobactrum
anthropi) 		PF05544
(Pro_racemase) 		3 TYR A 169
PRO A 145
LEU A 298
 None
 0.91A 6beoA-4k8lA:
undetectable		 6beoA-4k8lA:
3.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n0t U4/U6
SNRNA-ASSOCIATED-SPL
ICING FACTOR PRP24

(Saccharomyces
cerevisiae) 		PF00076
(RRM_1)
PF16842
(RRM_occluded) 		3 TYR A 162
PRO A 150
LEU A 149
 G  B  50 ( 3.5A)
A  B  51 ( 4.8A)
None
 0.70A 6beoA-4n0tA:
undetectable		 6beoA-4n0tA:
3.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4p9n CARBOXYLESTERASE

(Sulfolobus
shibatae) 		PF07859
(Abhydrolase_3) 		3 TYR A 172
PRO A 234
LEU A 170
 None
 0.89A 6beoA-4p9nA:
undetectable		 6beoA-4p9nA:
3.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4roa SERPIN 2

(Anopheles
gambiae) 		PF00079
(Serpin) 		3 TYR A 259
PRO A 250
LEU A 249
 None
 0.95A 6beoA-4roaA:
undetectable		 6beoA-4roaA:
3.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yhs MONOSACCHARIDE ABC
TRANSPORTER
SUBSTRATE-BINDING
PROTEIN, CUT2 FAMILY

(Bradyrhizobium
sp. BTAi1) 		PF13407
(Peripla_BP_4) 		3 TYR A  77
PRO A 344
LEU A  73
 None
 0.90A 6beoA-4yhsA:
undetectable		 6beoA-4yhsA:
3.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5azb PROLIPOPROTEIN
DIACYLGLYCERYL
TRANSFERASE

(Escherichia
coli) 		PF01790
(LGT) 		3 TYR A 190
PRO A 194
LEU A 193
 None
 0.80A 6beoA-5azbA:
undetectable		 6beoA-5azbA:
2.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5bxg UNCHARACTERIZED
BETA-SANDWICH
PROTEIN

(Clostridioides
difficile) 		no annotation 3 TYR A  83
PRO A  73
LEU A  72
 None
 0.85A 6beoA-5bxgA:
undetectable		 6beoA-5bxgA:
8.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5c7m E3 UBIQUITIN-PROTEIN
LIGASE ITCHY HOMOLOG
POLYUBIQUITIN-C

(Homo sapiens;
Homo sapiens) 		PF00632
(HECT)
PF00240
(ubiquitin) 		3 TYR A 609
PRO A 607
LEU B   8
 None
 0.90A 6beoA-5c7mA:
undetectable		 6beoA-5c7mA:
3.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5gvb WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1

(Homo sapiens) 		PF12341
(Mcl1_mid) 		3 TYR A 741
PRO A 638
LEU A 650
 None
 0.79A 6beoA-5gvbA:
undetectable		 6beoA-5gvbA:
1.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hee PUTATIVE
UNCHARACTERIZED
PROTEIN, TK2203
PROTEIN

(Thermococcus
kodakarensis) 		PF02900
(LigB) 		3 TYR A 224
PRO A 212
LEU A 215
 None
 0.84A 6beoA-5heeA:
undetectable		 6beoA-5heeA:
5.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hmp UNCONVENTIONAL
MYOSIN-VC

(Homo sapiens) 		PF00063
(Myosin_head) 		3 TYR A  77
PRO A  63
LEU A  66
 None
 0.77A 6beoA-5hmpA:
undetectable		 6beoA-5hmpA:
1.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5loa MESO-DIAMINOPIMELATE
D-DEHYDROGENASE

(Corynebacterium
glutamicum) 		PF16654
(DAPDH_C) 		3 TYR A 168
PRO A 146
LEU A 170
 None
 0.89A 6beoA-5loaA:
undetectable		 6beoA-5loaA:
4.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ltl C-C MOTIF CHEMOKINE
16

(Homo sapiens) 		no annotation 3 TYR A  19
PRO A  24
LEU A  27
 None
 0.93A 6beoA-5ltlA:
undetectable		 6beoA-5ltlA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mdx PHOTOSYSTEM II CP43
REACTION CENTER
PROTEIN

(Arabidopsis
thaliana) 		PF00421
(PSII) 		3 TYR C 111
PRO C  90
LEU C  86
 None
 0.92A 6beoA-5mdxC:
undetectable		 6beoA-5mdxC:
2.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mto INHIBITOR OF GROWTH
PROTEIN 5

(Homo sapiens) 		no annotation 3 TYR A  10
PRO A  18
LEU A  21
 None
 0.93A 6beoA-5mtoA:
undetectable		 6beoA-5mtoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5odr METHYL-VIOLOGEN
REDUCING
HYDROGENASE, SUBUNIT
A

(Methanothermococcus
thermolithotrophicus) 		PF00374
(NiFeSe_Hases) 		3 TYR F 258
PRO F 255
LEU F 240
 None
 0.87A 6beoA-5odrF:
undetectable		 6beoA-5odrF:
8.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogs WD REPEAT AND
HMG-BOX DNA-BINDING
PROTEIN 1

(Homo sapiens) 		no annotation 3 TYR A 741
PRO A 638
LEU A 650
 None
 0.79A 6beoA-5ogsA:
undetectable		 6beoA-5ogsA:
1.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ohk UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
30,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE
30,UBIQUITIN
CARBOXYL-TERMINAL
HYDROLASE 30

(Homo sapiens) 		PF00443
(UCH) 		3 TYR A 434
PRO A 318
LEU A 321
 None
 0.84A 6beoA-5ohkA:
undetectable		 6beoA-5ohkA:
3.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ojs TRANSCRIPTION-ASSOCI
ATED PROTEIN 1

(Saccharomyces
cerevisiae) 		PF00454
(PI3_PI4_kinase)
PF02259
(FAT) 		3 TYR T 710
PRO T 707
LEU T 706
 None
 0.94A 6beoA-5ojsT:
undetectable		 6beoA-5ojsT:
0.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5oki DNA POLYMERASE
EPSILON CATALYTIC
SUBUNIT A

(Saccharomyces
cerevisiae) 		no annotation 3 TYR A 431
PRO A 433
LEU A 432
 None
 0.91A 6beoA-5okiA:
undetectable		 6beoA-5okiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5uz5 U1 SMALL NUCLEAR
RIBONUCLEOPROTEIN
COMPONENT PRP42

(Saccharomyces
cerevisiae) 		no annotation 3 TYR D 263
PRO D 305
LEU D 304
 None
 0.92A 6beoA-5uz5D:
undetectable		 6beoA-5uz5D:
4.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5wc8 SIAD

(Mannheimia
haemolytica) 		no annotation 3 TYR M 106
PRO M  98
LEU M  94
 None
BR  M 503 ( 4.0A)
None
 0.76A 6beoA-5wc8M:
undetectable		 6beoA-5wc8M:
3.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5x9r CITRATE-SODIUM
SYMPORTER

(Klebsiella
pneumoniae) 		PF03390
(2HCT) 		3 TYR A 209
PRO A 192
LEU A 193
 None
 0.91A 6beoA-5x9rA:
undetectable		 6beoA-5x9rA:
2.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5xno CHLOROPHYLL A-B
BINDING PROTEIN,
CHLOROPLASTIC

(Pisum sativum) 		no annotation 3 TYR 3  33
PRO 3  42
LEU 3  45
 CHL  3 601 (-4.6A)
None
CLA  3 602 (-4.0A)
 0.95A 6beoA-5xno3:
undetectable		 6beoA-5xno3:
11.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aso U4/U6
SNRNA-ASSOCIATED-SPL
ICING FACTOR PRP24

(Saccharomyces
cerevisiae) 		no annotation 3 TYR A 162
PRO A 150
LEU A 149
 G  I  50 ( 3.4A)
None
None
 0.85A 6beoA-6asoA:
undetectable		 6beoA-6asoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6bfu SPIKE PROTEIN

(Coronavirus
HKU15) 		no annotation 3 TYR A 468
PRO A 483
LEU A 482
 None
 0.82A 6beoA-6bfuA:
undetectable		 6beoA-6bfuA:
1.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6f34 AMINO ACID
TRANSPORTER

(Geobacillus
kaustophilus) 		no annotation 3 TYR A  97
PRO A   8
LEU A  11
 None
 0.93A 6beoA-6f34A:
undetectable		 6beoA-6f34A:
undetectable