SIMILAR PATTERNS OF AMINO ACIDS FOR 6BC9_A_ETSA302_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jd0 CARBONIC ANHYDRASE
XII

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		11 TRP A   5
ASN A  62
GLN A  92
HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 199
THR A 200
PRO A 202
TRP A 209
 None
None
AZM  A1400 (-3.2A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.2A)
AZM  A1400 (-4.6A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
AZM  A1400 (-3.3A)
None
None
 0.51A 6bc9A-1jd0A:
36.7		 6bc9A-1jd0A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jd0 CARBONIC ANHYDRASE
XII

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		8 TRP A  16
HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 200
PRO A 202
TRP A 209
 None
ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.2A)
AZM  A1400 (-4.6A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.3A)
None
None
 1.49A 6bc9A-1jd0A:
36.7		 6bc9A-1jd0A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae) 		PF00194
(Carb_anhydrase) 		11 TRP A   7
ASN A  64
GLN A  90
HIS A  92
HIS A  94
VAL A 113
LEU A 176
THR A 177
THR A 178
PRO A 180
TRP A 187
 None
BME  A 303 (-4.7A)
None
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.3A)
None
AZI  A 305 (-4.2A)
AZI  A 305 (-3.4A)
AZI  A 305 ( 4.2A)
None
None
 0.49A 6bc9A-1kopA:
29.8		 6bc9A-1kopA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae) 		PF00194
(Carb_anhydrase) 		7 TRP A   7
GLN A  69
HIS A  92
HIS A  94
LEU A 176
THR A 177
THR A 178
 None
None
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.3A)
AZI  A 305 (-4.2A)
AZI  A 305 (-3.4A)
AZI  A 305 ( 4.2A)
 1.13A 6bc9A-1kopA:
29.8		 6bc9A-1kopA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae) 		PF00194
(Carb_anhydrase) 		7 TRP A   7
HIS A  92
LEU A 176
THR A 177
THR A 178
PRO A 180
TRP A 187
 None
ZN  A 301 ( 3.2A)
AZI  A 305 (-4.2A)
AZI  A 305 (-3.4A)
AZI  A 305 ( 4.2A)
None
None
 1.34A 6bc9A-1kopA:
29.8		 6bc9A-1kopA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae) 		PF00194
(Carb_anhydrase) 		6 TRP A   7
HIS A  94
VAL A 123
LEU A 176
THR A 178
PRO A 180
 None
ZN  A 301 ( 3.3A)
None
AZI  A 305 (-4.2A)
AZI  A 305 ( 4.2A)
None
 1.24A 6bc9A-1kopA:
29.8		 6bc9A-1kopA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		11 TRP A   5
ASN A  62
GLN A  92
HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 199
THR A 200
PRO A 202
TRP A 209
 None
None
AZM  A 400 (-4.3A)
ZN  A 601 ( 3.3A)
ZN  A 601 (-3.3A)
AZM  A 400 (-4.8A)
AZM  A 400 (-3.7A)
AZM  A 400 (-3.6A)
AZM  A 400 (-3.6A)
None
None
 0.66A 6bc9A-1rj6A:
37.1		 6bc9A-1rj6A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		7 TRP A   5
GLN A  67
HIS A  94
HIS A  96
LEU A 198
THR A 199
THR A 200
 None
None
ZN  A 601 ( 3.3A)
ZN  A 601 (-3.3A)
AZM  A 400 (-3.7A)
AZM  A 400 (-3.6A)
AZM  A 400 (-3.6A)
 1.10A 6bc9A-1rj6A:
37.1		 6bc9A-1rj6A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		7 TRP A   5
HIS A  94
LEU A 198
THR A 199
THR A 200
PRO A 202
TRP A 209
 None
ZN  A 601 ( 3.3A)
AZM  A 400 (-3.7A)
AZM  A 400 (-3.6A)
AZM  A 400 (-3.6A)
None
None
 1.39A 6bc9A-1rj6A:
37.1		 6bc9A-1rj6A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urt CARBONIC ANHYDRASE V

(Mus musculus) 		PF00194
(Carb_anhydrase) 		9 GLN A  92
HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 199
THR A 200
PRO A 202
TRP A 209
 None
ZN  A 280 (-3.2A)
ZN  A 280 (-3.2A)
None
None
ZN  A 280 ( 4.9A)
None
None
None
 0.40A 6bc9A-1urtA:
37.0		 6bc9A-1urtA:
26.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urt CARBONIC ANHYDRASE V

(Mus musculus) 		PF00194
(Carb_anhydrase) 		6 HIS A  96
VAL A 143
LEU A 198
THR A 199
THR A 200
PRO A 202
 ZN  A 280 (-3.2A)
None
None
ZN  A 280 ( 4.9A)
None
None
 0.93A 6bc9A-1urtA:
37.0		 6bc9A-1urtA:
26.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7w HALOTOLERANT
ALPHA-TYPE CARBONIC
ANHYDRASE (DCA II)

(Dunaliella
salina) 		PF00194
(Carb_anhydrase) 		8 GLN A 113
HIS A 115
HIS A 117
VAL A 137
LEU A 216
THR A 217
THR A 218
TRP A 227
 None
ZN  A 283 ( 3.2A)
ZN  A 283 (-3.2A)
ACY  A 279 ( 4.7A)
ACY  A 279 (-4.3A)
ACY  A 279 (-3.4A)
ACY  A 279 ( 4.9A)
None
 0.20A 6bc9A-1y7wA:
26.2		 6bc9A-1y7wA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2it4 CARBONIC ANHYDRASE 1

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		8 TRP A   5
GLN A  92
HIS A  94
HIS A  96
LEU A 198
THR A 199
PRO A 202
TRP A 209
 None
None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
None
 0.49A 6bc9A-2it4A:
40.9		 6bc9A-2it4A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2it4 CARBONIC ANHYDRASE 1

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 TRP A   5
HIS A  96
VAL A 143
LEU A 198
THR A 199
PRO A 202
 None
ZN  A 561 ( 3.2A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 1.16A 6bc9A-2it4A:
40.9		 6bc9A-2it4A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2j CARBONIC
ANHYDRASE-RELATED
PROTEIN

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 TRP A  29
HIS A 118
LEU A 222
THR A 223
PRO A 226
TRP A 233
 None
CL  A 401 (-4.2A)
None
CL  A 401 ( 4.8A)
None
None
 0.38A 6bc9A-2w2jA:
37.3		 6bc9A-2w2jA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2znc CARBONIC ANHYDRASE
IV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		6 HIS A 119
HIS A  96
VAL A 143
LEU A 198
THR A 199
THR A 200
 ZN  A   1 ( 3.2A)
ZN  A   1 ( 3.3A)
None
None
ZN  A   1 ( 4.7A)
None
 1.34A 6bc9A-2zncA:
32.4		 6bc9A-2zncA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2znc CARBONIC ANHYDRASE
IV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		10 TRP A   5
ASN A  62
GLN A  92
HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 199
THR A 200
TRP A 209
 None
None
None
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
None
None
ZN  A   1 ( 4.7A)
None
None
 0.38A 6bc9A-2zncA:
32.4		 6bc9A-2zncA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2znc CARBONIC ANHYDRASE
IV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		6 TRP A   5
HIS A  96
VAL A 143
LEU A 198
THR A 199
THR A 200
 None
ZN  A   1 ( 3.3A)
None
None
ZN  A   1 ( 4.7A)
None
 1.14A 6bc9A-2zncA:
32.4		 6bc9A-2zncA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2znc CARBONIC ANHYDRASE
IV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		8 TRP A  16
HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 199
THR A 200
TRP A 209
 None
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
None
None
ZN  A   1 ( 4.7A)
None
None
 1.43A 6bc9A-2zncA:
32.4		 6bc9A-2zncA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		11 TRP A  40
ASN A 110
GLN A 161
HIS A 163
HIS A 165
VAL A 184
LEU A 259
THR A 260
THR A 261
PRO A 263
TRP A 270
 None
None
None
ZN  A 378 (-3.2A)
ZN  A 378 (-3.3A)
None
None
ZN  A 378 ( 4.5A)
None
None
None
 0.44A 6bc9A-3b1bA:
25.0		 6bc9A-3b1bA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		7 TRP A  40
GLN A 115
HIS A 163
HIS A 165
LEU A 259
THR A 260
THR A 261
 None
None
ZN  A 378 (-3.2A)
ZN  A 378 (-3.3A)
None
ZN  A 378 ( 4.5A)
None
 1.07A 6bc9A-3b1bA:
25.0		 6bc9A-3b1bA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		7 TRP A  40
HIS A 163
LEU A 259
THR A 260
THR A 261
PRO A 263
TRP A 270
 None
ZN  A 378 (-3.2A)
None
ZN  A 378 ( 4.5A)
None
None
None
 1.22A 6bc9A-3b1bA:
25.0		 6bc9A-3b1bA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		6 TRP A  40
HIS A 165
VAL A 201
LEU A 259
THR A 261
PRO A 263
 None
ZN  A 378 (-3.3A)
None
None
None
None
 1.22A 6bc9A-3b1bA:
25.0		 6bc9A-3b1bA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		7 TRP A  49
HIS A 163
HIS A 165
VAL A 184
LEU A 259
THR A 261
TRP A 270
 None
ZN  A 378 (-3.2A)
ZN  A 378 (-3.3A)
None
None
None
None
 1.50A 6bc9A-3b1bA:
25.0		 6bc9A-3b1bA:
11.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3da2 CARBONIC ANHYDRASE
13

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 ASN A  68
HIS A  97
LEU A 199
THR A 200
PRO A 203
TRP A 210
 None
ZN  A 301 ( 3.5A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
4MD  A 401 ( 4.9A)
None
 1.13A 6bc9A-3da2A:
42.4		 6bc9A-3da2A:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3da2 CARBONIC ANHYDRASE
13

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		8 TRP A   6
GLN A  93
HIS A  95
HIS A  97
VAL A 122
LEU A 199
THR A 200
PRO A 203
 None
4MD  A 401 (-3.1A)
ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.5A)
4MD  A 401 ( 4.6A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
4MD  A 401 ( 4.9A)
 0.85A 6bc9A-3da2A:
42.4		 6bc9A-3da2A:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3da2 CARBONIC ANHYDRASE
13

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		8 TRP A   6
GLN A  93
HIS A  97
VAL A 122
PHE A 132
LEU A 199
THR A 200
PRO A 203
 None
4MD  A 401 (-3.1A)
ZN  A 301 ( 3.5A)
4MD  A 401 ( 4.6A)
4MD  A 401 (-4.6A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
4MD  A 401 ( 4.9A)
 0.83A 6bc9A-3da2A:
42.4		 6bc9A-3da2A:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3da2 CARBONIC ANHYDRASE
13

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		8 TRP A   6
HIS A  95
HIS A  97
VAL A 122
LEU A 199
THR A 200
PRO A 203
TRP A 210
 None
ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.5A)
4MD  A 401 ( 4.6A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
4MD  A 401 ( 4.9A)
None
 0.45A 6bc9A-3da2A:
42.4		 6bc9A-3da2A:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3da2 CARBONIC ANHYDRASE
13

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		8 TRP A   6
HIS A  97
VAL A 122
PHE A 132
LEU A 199
THR A 200
PRO A 203
TRP A 210
 None
ZN  A 301 ( 3.5A)
4MD  A 401 ( 4.6A)
4MD  A 401 (-4.6A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
4MD  A 401 ( 4.9A)
None
 0.33A 6bc9A-3da2A:
42.4		 6bc9A-3da2A:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3da2 CARBONIC ANHYDRASE
13

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 TRP A  17
HIS A  95
HIS A  97
VAL A 122
LEU A 199
THR A 200
TRP A 210
 None
ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.5A)
4MD  A 401 ( 4.6A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
None
 1.48A 6bc9A-3da2A:
42.4		 6bc9A-3da2A:
30.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe4 CARBONIC ANHYDRASE 6

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		8 ASN A  83
GLN A 109
HIS A 111
HIS A 113
VAL A 140
LEU A 219
THR A 220
TRP A 230
 None
None
MG  A 901 (-3.4A)
MG  A 901 (-3.4A)
None
None
None
None
 0.69A 6bc9A-3fe4A:
31.6		 6bc9A-3fe4A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jxf RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 TRP A  38
HIS A 129
LEU A 235
THR A 236
PRO A 239
TRP A 246
 None
 0.48A 6bc9A-3jxfA:
33.5		 6bc9A-3jxfA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 GLN A  92
HIS A  94
HIS A  96
VAL A 121
PHE A 131
LEU A 198
THR A 199
 AZM  A 264 (-4.1A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
AZM  A 264 (-4.7A)
AZM  A 264 (-4.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
 1.38A 6bc9A-3ml5A:
43.0		 6bc9A-3ml5A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		12 TRP A   5
ASN A  62
GLN A  92
HIS A  94
HIS A  96
VAL A 121
PHE A 131
LEU A 198
THR A 199
THR A 200
PRO A 202
TRP A 209
 None
None
AZM  A 264 (-4.1A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
AZM  A 264 (-4.7A)
AZM  A 264 (-4.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
None
None
 0.48A 6bc9A-3ml5A:
43.0		 6bc9A-3ml5A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		8 TRP A   5
GLN A  67
HIS A  94
HIS A  96
LEU A 198
THR A 199
THR A 200
PRO A 202
 None
None
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
None
 1.10A 6bc9A-3ml5A:
43.0		 6bc9A-3ml5A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 TRP A   5
HIS A  94
LEU A 198
THR A 199
THR A 200
PRO A 202
TRP A 209
 None
ZN  A 263 ( 3.2A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
None
None
 1.32A 6bc9A-3ml5A:
43.0		 6bc9A-3ml5A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 TRP A   5
HIS A  96
VAL A 143
LEU A 198
THR A 200
PRO A 202
 None
ZN  A 263 ( 3.2A)
AZM  A 264 ( 4.9A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
None
 1.02A 6bc9A-3ml5A:
43.0		 6bc9A-3ml5A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 TRP A  16
HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 200
TRP A 209
 None
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
AZM  A 264 (-4.7A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
None
 1.46A 6bc9A-3ml5A:
43.0		 6bc9A-3ml5A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q31 CARBONIC ANHYDRASE

(Aspergillus
oryzae) 		PF00194
(Carb_anhydrase) 		9 GLN A 121
HIS A 123
HIS A 125
VAL A 144
LEU A 214
THR A 215
THR A 216
PRO A 218
TRP A 225
 MLT  A   3 (-3.9A)
ZN  A   1 ( 3.2A)
ZN  A   1 (-3.3A)
None
MLT  A   3 ( 4.2A)
MLT  A   3 ( 4.3A)
MLT  A   3 (-2.8A)
None
MLT  A   3 (-4.9A)
 0.51A 6bc9A-3q31A:
24.3		 6bc9A-3q31A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q31 CARBONIC ANHYDRASE

(Aspergillus
oryzae) 		PF00194
(Carb_anhydrase) 		7 TRP A  48
HIS A 123
HIS A 125
VAL A 144
LEU A 214
THR A 216
TRP A 225
 None
ZN  A   1 ( 3.2A)
ZN  A   1 (-3.3A)
None
MLT  A   3 ( 4.2A)
MLT  A   3 (-2.8A)
MLT  A   3 (-4.9A)
 1.34A 6bc9A-3q31A:
24.3		 6bc9A-3q31A:
15.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uyq CARBONIC ANHYDRASE 3

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 GLN A  92
HIS A  94
HIS A  96
VAL A 121
PHE A 130
THR A 198
 None
ZN  A 261 (-3.3A)
ZN  A 261 (-3.3A)
None
None
ZN  A 261 ( 4.4A)
 1.22A 6bc9A-3uyqA:
41.3		 6bc9A-3uyqA:
32.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uyq CARBONIC ANHYDRASE 3

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		10 TRP A   5
ASN A  62
GLN A  92
HIS A  94
HIS A  96
VAL A 121
PHE A 130
THR A 198
THR A 199
PRO A 201
 None
None
None
ZN  A 261 (-3.3A)
ZN  A 261 (-3.3A)
None
None
ZN  A 261 ( 4.4A)
None
None
 0.56A 6bc9A-3uyqA:
41.3		 6bc9A-3uyqA:
32.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uyq CARBONIC ANHYDRASE 3

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		10 TRP A   5
ASN A  62
GLN A  92
HIS A  94
HIS A  96
VAL A 121
PHE A 130
THR A 198
THR A 199
TRP A 208
 None
None
None
ZN  A 261 (-3.3A)
ZN  A 261 (-3.3A)
None
None
ZN  A 261 ( 4.4A)
None
None
 0.50A 6bc9A-3uyqA:
41.3		 6bc9A-3uyqA:
32.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		11 TRP A   3
ASN A  62
GLN A  87
HIS A  89
HIS A  91
VAL A 110
LEU A 173
THR A 174
THR A 175
PRO A 177
TRP A 184
 None
None
AZM  A 302 (-4.4A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
AZM  A 302 (-4.7A)
AZM  A 302 (-3.8A)
AZM  A 302 (-3.4A)
AZM  A 302 (-3.4A)
None
None
 0.50A 6bc9A-4g7aA:
30.1		 6bc9A-4g7aA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		6 TRP A   3
GLN A  67
HIS A  91
LEU A 173
THR A 174
THR A 175
 None
None
ZN  A 301 ( 3.2A)
AZM  A 302 (-3.8A)
AZM  A 302 (-3.4A)
AZM  A 302 (-3.4A)
 1.17A 6bc9A-4g7aA:
30.1		 6bc9A-4g7aA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		7 TRP A   3
HIS A  89
HIS A  91
VAL A 120
LEU A 173
THR A 175
PRO A 177
 None
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
AZM  A 302 ( 4.8A)
AZM  A 302 (-3.8A)
AZM  A 302 (-3.4A)
None
 1.22A 6bc9A-4g7aA:
30.1		 6bc9A-4g7aA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		6 TRP A   3
HIS A  89
LEU A 173
THR A 175
PRO A 177
TRP A 184
 None
ZN  A 301 ( 3.2A)
AZM  A 302 (-3.8A)
AZM  A 302 (-3.4A)
None
None
 1.32A 6bc9A-4g7aA:
30.1		 6bc9A-4g7aA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		7 TRP A  14
HIS A  89
HIS A  91
VAL A 110
LEU A 173
THR A 175
TRP A 184
 None
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
AZM  A 302 (-4.7A)
AZM  A 302 (-3.8A)
AZM  A 302 (-3.4A)
None
 1.50A 6bc9A-4g7aA:
30.1		 6bc9A-4g7aA:
17.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 ASN A  67
HIS A  96
LEU A 198
THR A 199
THR A 200
PRO A 202
 None
ZN  A 301 (-3.2A)
None
ZN  A 301 ( 4.4A)
None
None
 1.05A 6bc9A-4qk3A:
43.8		 6bc9A-4qk3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 ASN A  67
HIS A  96
VAL A 143
LEU A 198
THR A 200
PRO A 202
 None
ZN  A 301 (-3.2A)
None
None
None
None
 1.03A 6bc9A-4qk3A:
43.8		 6bc9A-4qk3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 GLN A  92
HIS A  94
HIS A  96
VAL A 121
PHE A 131
LEU A 198
THR A 199
 None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
None
None
None
ZN  A 301 ( 4.4A)
 1.39A 6bc9A-4qk3A:
43.8		 6bc9A-4qk3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		12 TRP A   5
ASN A  62
GLN A  92
HIS A  94
HIS A  96
VAL A 121
PHE A 131
LEU A 198
THR A 199
THR A 200
PRO A 202
TRP A 209
 None
None
None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
None
None
None
ZN  A 301 ( 4.4A)
None
None
None
 0.31A 6bc9A-4qk3A:
43.8		 6bc9A-4qk3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 TRP A   5
HIS A  94
LEU A 198
THR A 199
THR A 200
PRO A 202
TRP A 209
 None
ZN  A 301 (-3.2A)
None
ZN  A 301 ( 4.4A)
None
None
None
 1.27A 6bc9A-4qk3A:
43.8		 6bc9A-4qk3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 TRP A   5
HIS A  96
VAL A 143
LEU A 198
THR A 200
PRO A 202
 None
ZN  A 301 (-3.2A)
None
None
None
None
 1.18A 6bc9A-4qk3A:
43.8		 6bc9A-4qk3A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uov CARBONATE
DEHYDRATASE

(Thermovibrio
ammonificans) 		PF00194
(Carb_anhydrase) 		10 TRP A  26
ASN A  85
GLN A 110
HIS A 112
HIS A 114
VAL A 133
LEU A 197
THR A 198
THR A 199
TRP A 208
 None
None
CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.38A 6bc9A-4uovA:
31.3		 6bc9A-4uovA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uov CARBONATE
DEHYDRATASE

(Thermovibrio
ammonificans) 		PF00194
(Carb_anhydrase) 		10 TRP A  26
GLN A 110
HIS A 112
HIS A 114
VAL A 133
LEU A 197
THR A 198
THR A 199
PRO A 201
TRP A 208
 None
CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
None
 0.54A 6bc9A-4uovA:
31.3		 6bc9A-4uovA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uov CARBONATE
DEHYDRATASE

(Thermovibrio
ammonificans) 		PF00194
(Carb_anhydrase) 		7 TRP A  26
HIS A 112
HIS A 114
VAL A 143
LEU A 197
THR A 199
PRO A 201
 None
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
 1.30A 6bc9A-4uovA:
31.3		 6bc9A-4uovA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uov CARBONATE
DEHYDRATASE

(Thermovibrio
ammonificans) 		PF00194
(Carb_anhydrase) 		6 TRP A  26
HIS A 112
LEU A 197
THR A 199
PRO A 201
TRP A 208
 None
ZN  A 298 (-3.2A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
None
 1.31A 6bc9A-4uovA:
31.3		 6bc9A-4uovA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uov CARBONATE
DEHYDRATASE

(Thermovibrio
ammonificans) 		PF00194
(Carb_anhydrase) 		6 TRP A  26
HIS A 114
LEU A 197
THR A 198
THR A 199
TRP A 208
 None
ZN  A 298 ( 3.2A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 1.23A 6bc9A-4uovA:
31.3		 6bc9A-4uovA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)

(Sulfurihydrogenibium
azorense) 		PF00194
(Carb_anhydrase) 		11 TRP A   3
ASN A  62
GLN A  87
HIS A  89
HIS A  91
VAL A 110
LEU A 173
THR A 174
THR A 175
PRO A 177
TRP A 184
 None
None
AZM  A 302 (-4.3A)
ZN  A 301 ( 3.1A)
ZN  A 301 ( 3.2A)
AZM  A 302 (-4.8A)
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
AZM  A 302 (-3.3A)
None
None
 0.50A 6bc9A-4x5sA:
30.0		 6bc9A-4x5sA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)

(Sulfurihydrogenibium
azorense) 		PF00194
(Carb_anhydrase) 		6 TRP A   3
GLN A  67
HIS A  91
LEU A 173
THR A 174
THR A 175
 None
None
ZN  A 301 ( 3.2A)
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
AZM  A 302 (-3.3A)
 1.12A 6bc9A-4x5sA:
30.0		 6bc9A-4x5sA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)

(Sulfurihydrogenibium
azorense) 		PF00194
(Carb_anhydrase) 		7 TRP A   3
HIS A  89
HIS A  91
VAL A 120
LEU A 173
THR A 175
PRO A 177
 None
ZN  A 301 ( 3.1A)
ZN  A 301 ( 3.2A)
AZM  A 302 ( 4.8A)
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
None
 1.26A 6bc9A-4x5sA:
30.0		 6bc9A-4x5sA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)

(Sulfurihydrogenibium
azorense) 		PF00194
(Carb_anhydrase) 		7 TRP A   3
HIS A  89
LEU A 173
THR A 174
THR A 175
PRO A 177
TRP A 184
 None
ZN  A 301 ( 3.1A)
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
AZM  A 302 (-3.3A)
None
None
 1.34A 6bc9A-4x5sA:
30.0		 6bc9A-4x5sA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfw ALPHA-CARBONIC
ANHYDRASE

(Helicobacter
pylori) 		PF00194
(Carb_anhydrase) 		8 TRP A  23
HIS A 110
HIS A 112
VAL A 131
LEU A 190
THR A 191
PRO A 194
TRP A 201
 None
ZN  A 301 (-3.3A)
ZN  A 301 (-3.4A)
None
None
ZN  A 301 (-4.3A)
None
None
 0.51A 6bc9A-4xfwA:
26.5		 6bc9A-4xfwA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfw ALPHA-CARBONIC
ANHYDRASE

(Helicobacter
pylori) 		PF00194
(Carb_anhydrase) 		7 TRP A  35
HIS A 110
HIS A 112
VAL A 131
LEU A 190
THR A 191
TRP A 201
 None
ZN  A 301 (-3.3A)
ZN  A 301 (-3.4A)
None
None
ZN  A 301 (-4.3A)
None
 1.28A 6bc9A-4xfwA:
26.5		 6bc9A-4xfwA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		9 GLN A 158
HIS A 160
HIS A 162
VAL A 181
LEU A 253
THR A 254
THR A 255
PRO A 257
TRP A 264
 None
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.2A)
None
2HP  A 402 (-3.4A)
2HP  A 402 (-2.9A)
2HP  A 402 (-3.6A)
None
None
 0.44A 6bc9A-4xixA:
25.8		 6bc9A-4xixA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		8 TRP A  86
HIS A 160
HIS A 162
VAL A 181
LEU A 253
THR A 254
THR A 255
TRP A 264
 None
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.2A)
None
2HP  A 402 (-3.4A)
2HP  A 402 (-2.9A)
2HP  A 402 (-3.6A)
None
 1.47A 6bc9A-4xixA:
25.8		 6bc9A-4xixA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		11 TRP A  78
ASN A 138
GLN A 163
HIS A 165
HIS A 167
VAL A 186
LEU A 251
THR A 252
THR A 253
PRO A 255
TRP A 262
 None
None
None
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.3A)
None
BCT  A 402 (-3.8A)
BCT  A 402 (-3.7A)
BCT  A 402 ( 4.4A)
None
None
 0.45A 6bc9A-4xz5A:
29.8		 6bc9A-4xz5A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		6 TRP A  78
HIS A 165
LEU A 251
THR A 253
PRO A 255
TRP A 262
 None
ZN  A 401 ( 3.2A)
BCT  A 402 (-3.8A)
BCT  A 402 ( 4.4A)
None
None
 1.22A 6bc9A-4xz5A:
29.8		 6bc9A-4xz5A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		6 TRP A  78
HIS A 167
LEU A 251
THR A 252
THR A 253
TRP A 262
 None
ZN  A 401 ( 3.3A)
BCT  A 402 (-3.8A)
BCT  A 402 (-3.7A)
BCT  A 402 ( 4.4A)
None
 1.25A 6bc9A-4xz5A:
29.8		 6bc9A-4xz5A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		7 TRP A  78
HIS A 167
VAL A 196
LEU A 251
THR A 252
THR A 253
PRO A 255
 None
ZN  A 401 ( 3.3A)
None
BCT  A 402 (-3.8A)
BCT  A 402 (-3.7A)
BCT  A 402 ( 4.4A)
None
 1.14A 6bc9A-4xz5A:
29.8		 6bc9A-4xz5A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		7 TRP A  89
HIS A 165
HIS A 167
VAL A 186
LEU A 251
THR A 253
TRP A 262
 None
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.3A)
None
BCT  A 402 (-3.8A)
BCT  A 402 ( 4.4A)
None
 1.46A 6bc9A-4xz5A:
29.8		 6bc9A-4xz5A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		11 TRP A   5
ASN A  62
GLN A  92
HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 199
THR A 200
PRO A 202
TRP A 209
 None
GOL  A 303 (-3.9A)
GOL  A 303 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
None
None
 0.46A 6bc9A-5cjfA:
36.8		 6bc9A-5cjfA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 TRP A   5
GLN A  67
HIS A  94
HIS A  96
LEU A 198
THR A 199
THR A 200
 None
GOL  A 303 (-3.4A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
 1.15A 6bc9A-5cjfA:
36.8		 6bc9A-5cjfA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 TRP A   5
HIS A  94
LEU A 198
THR A 200
PRO A 202
TRP A 209
 None
ZN  A 301 (-3.2A)
520  A 302 (-3.6A)
GOL  A 303 ( 3.5A)
None
None
 1.30A 6bc9A-5cjfA:
36.8		 6bc9A-5cjfA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 TRP A   5
HIS A  96
VAL A 143
LEU A 198
THR A 199
THR A 200
 None
ZN  A 301 ( 3.2A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
 1.08A 6bc9A-5cjfA:
36.8		 6bc9A-5cjfA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		9 TRP A  16
HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 199
THR A 200
PRO A 202
TRP A 209
 None
ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
None
None
 1.44A 6bc9A-5cjfA:
36.8		 6bc9A-5cjfA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e5u RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE GAMMA

(Mus musculus) 		PF00194
(Carb_anhydrase) 		8 TRP A  60
HIS A 151
PHE A 187
LEU A 256
THR A 257
THR A 258
PRO A 260
TRP A 267
 None
 0.89A 6bc9A-5e5uA:
34.2		 6bc9A-5e5uA:
14.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		6 ASN X  66
HIS X  95
LEU X 196
THR X 197
THR X 198
PRO X 200
 None
ZN  X 301 (-3.2A)
None
ZN  X 301 ( 4.4A)
None
None
 1.10A 6bc9A-5eztX:
44.2		 6bc9A-5eztX:
77.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		6 ASN X  66
HIS X  95
VAL X 141
LEU X 196
THR X 198
PRO X 200
 None
ZN  X 301 (-3.2A)
None
None
None
None
 1.06A 6bc9A-5eztX:
44.2		 6bc9A-5eztX:
77.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		7 GLN X  91
HIS X  93
HIS X  95
VAL X 120
PHE X 129
LEU X 196
THR X 197
 None
ZN  X 301 (-3.2A)
ZN  X 301 (-3.2A)
None
None
None
ZN  X 301 ( 4.4A)
 1.44A 6bc9A-5eztX:
44.2		 6bc9A-5eztX:
77.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		12 TRP X   4
ASN X  61
GLN X  91
HIS X  93
HIS X  95
VAL X 120
PHE X 129
LEU X 196
THR X 197
THR X 198
PRO X 200
TRP X 207
 None
None
None
ZN  X 301 (-3.2A)
ZN  X 301 (-3.2A)
None
None
None
ZN  X 301 ( 4.4A)
None
None
None
 0.35A 6bc9A-5eztX:
44.2		 6bc9A-5eztX:
77.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		7 TRP X   4
HIS X  93
LEU X 196
THR X 197
THR X 198
PRO X 200
TRP X 207
 None
ZN  X 301 (-3.2A)
None
ZN  X 301 ( 4.4A)
None
None
None
 1.35A 6bc9A-5eztX:
44.2		 6bc9A-5eztX:
77.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		6 TRP X   4
HIS X  95
VAL X 141
LEU X 196
THR X 198
PRO X 200
 None
ZN  X 301 (-3.2A)
None
None
None
None
 1.20A 6bc9A-5eztX:
44.2		 6bc9A-5eztX:
77.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		11 TRP A  15
ASN A  69
GLN A  94
HIS A  96
HIS A  98
VAL A 117
LEU A 181
THR A 182
THR A 183
PRO A 185
TRP A 192
 None
None
None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
None
None
ZN  A 301 ( 4.4A)
None
None
None
 0.55A 6bc9A-5hpjA:
29.4		 6bc9A-5hpjA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		7 TRP A  15
HIS A  96
LEU A 181
THR A 182
THR A 183
PRO A 185
TRP A 192
 None
ZN  A 301 (-3.2A)
None
ZN  A 301 ( 4.4A)
None
None
None
 1.29A 6bc9A-5hpjA:
29.4		 6bc9A-5hpjA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		6 TRP A  15
HIS A  98
VAL A 127
LEU A 181
THR A 183
PRO A 185
 None
ZN  A 301 (-3.2A)
None
None
None
None
 1.07A 6bc9A-5hpjA:
29.4		 6bc9A-5hpjA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		7 TRP A  26
HIS A  96
HIS A  98
VAL A 117
LEU A 181
THR A 183
TRP A 192
 None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
None
None
None
None
 1.39A 6bc9A-5hpjA:
29.4		 6bc9A-5hpjA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jn9 CARBONIC ANHYDRASE 4

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		10 TRP A   5
ASN A  62
GLN A  92
HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 199
THR A 200
TRP A 209
 None
None
EZL  A 302 (-4.3A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
EZL  A 302 (-4.7A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.4A)
EZL  A 302 (-3.9A)
None
 0.42A 6bc9A-5jn9A:
33.5		 6bc9A-5jn9A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jn9 CARBONIC ANHYDRASE 4

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 TRP A   5
HIS A  94
HIS A  96
VAL A 143
LEU A 198
THR A 200
 None
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
EZL  A 302 ( 4.7A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.9A)
 1.34A 6bc9A-5jn9A:
33.5		 6bc9A-5jn9A:
13.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6eki CARBONIC ANHYDRASE

(Persephonella
marina) 		no annotation 11 TRP A  33
ASN A  90
GLN A 115
HIS A 117
HIS A 119
VAL A 138
LEU A 201
THR A 202
THR A 203
PRO A 205
TRP A 212
 None
None
None
ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
None
None
ZN  A 301 (-4.4A)
None
None
None
 0.56A 6bc9A-6ekiA:
30.0		 6bc9A-6ekiA:
32.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6eki CARBONIC ANHYDRASE

(Persephonella
marina) 		no annotation 6 TRP A  33
HIS A 117
LEU A 201
THR A 203
PRO A 205
TRP A 212
 None
ZN  A 301 (-3.3A)
None
None
None
None
 1.35A 6bc9A-6ekiA:
30.0		 6bc9A-6ekiA:
32.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6eki CARBONIC ANHYDRASE

(Persephonella
marina) 		no annotation 6 TRP A  33
HIS A 119
VAL A 148
LEU A 201
THR A 203
PRO A 205
 None
ZN  A 301 (-3.3A)
None
None
None
None
 1.21A 6bc9A-6ekiA:
30.0		 6bc9A-6ekiA:
32.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6eki CARBONIC ANHYDRASE

(Persephonella
marina) 		no annotation 7 TRP A  44
HIS A 117
HIS A 119
VAL A 138
LEU A 201
THR A 203
TRP A 212
 None
ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
None
None
None
None
 1.45A 6bc9A-6ekiA:
30.0		 6bc9A-6ekiA:
32.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6fe1 CARBONIC ANHYDRASE 9

(Homo sapiens) 		no annotation 6 ASN A  62
HIS A  94
HIS A  96
THR A 199
PRO A 201
TRP A 209
 V14  A 302 (-3.4A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
V14  A 302 (-3.2A)
None
None
 1.24A 6bc9A-6fe1A:
33.9		 6bc9A-6fe1A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6fe1 CARBONIC ANHYDRASE 9

(Homo sapiens) 		no annotation 11 TRP A   5
ASN A  62
GLN A  92
HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 199
THR A 200
PRO A 202
TRP A 209
 None
V14  A 302 (-3.4A)
V14  A 302 (-3.8A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
V14  A 302 (-4.7A)
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
V14  A 302 (-3.5A)
None
None
 0.51A 6bc9A-6fe1A:
33.9		 6bc9A-6fe1A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6fe1 CARBONIC ANHYDRASE 9

(Homo sapiens) 		no annotation 8 TRP A   5
HIS A  94
HIS A  96
VAL A 143
LEU A 198
THR A 199
THR A 200
PRO A 202
 None
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
None
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
V14  A 302 (-3.5A)
None
 1.10A 6bc9A-6fe1A:
33.9		 6bc9A-6fe1A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6fe1 CARBONIC ANHYDRASE 9

(Homo sapiens) 		no annotation 6 TRP A   5
HIS A  94
LEU A 198
THR A 200
PRO A 202
TRP A 209
 None
ZN  A 301 ( 3.2A)
V14  A 302 (-3.6A)
V14  A 302 (-3.5A)
None
None
 1.34A 6bc9A-6fe1A:
33.9		 6bc9A-6fe1A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6fe1 CARBONIC ANHYDRASE 9

(Homo sapiens) 		no annotation 6 TRP A   5
HIS A  96
LEU A 198
THR A 199
THR A 200
TRP A 209
 None
ZN  A 301 ( 3.2A)
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
V14  A 302 (-3.5A)
None
 1.21A 6bc9A-6fe1A:
33.9		 6bc9A-6fe1A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6fe1 CARBONIC ANHYDRASE 9

(Homo sapiens) 		no annotation 7 TRP A  16
HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 200
TRP A 209
 None
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
V14  A 302 (-4.7A)
V14  A 302 (-3.6A)
V14  A 302 (-3.5A)
None
 1.46A 6bc9A-6fe1A:
33.9		 6bc9A-6fe1A:
33.33