SIMILAR PATTERNS OF AMINO ACIDS FOR 6BC9_A_ETSA302

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jd0 CARBONIC ANHYDRASE
XII

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		11 TRP A   5
ASN A  62
GLN A  92
HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 199
THR A 200
PRO A 202
TRP A 209
 None
None
AZM  A1400 (-3.2A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.2A)
AZM  A1400 (-4.6A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
AZM  A1400 (-3.3A)
None
None
 0.51A 6bc9A-1jd0A:
36.7		 6bc9A-1jd0A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jd0 CARBONIC ANHYDRASE
XII

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		8 TRP A  16
HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 200
PRO A 202
TRP A 209
 None
ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.2A)
AZM  A1400 (-4.6A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.3A)
None
None
 1.49A 6bc9A-1jd0A:
36.7		 6bc9A-1jd0A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae) 		PF00194
(Carb_anhydrase) 		11 TRP A   7
ASN A  64
GLN A  90
HIS A  92
HIS A  94
VAL A 113
LEU A 176
THR A 177
THR A 178
PRO A 180
TRP A 187
 None
BME  A 303 (-4.7A)
None
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.3A)
None
AZI  A 305 (-4.2A)
AZI  A 305 (-3.4A)
AZI  A 305 ( 4.2A)
None
None
 0.49A 6bc9A-1kopA:
29.8		 6bc9A-1kopA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae) 		PF00194
(Carb_anhydrase) 		7 TRP A   7
GLN A  69
HIS A  92
HIS A  94
LEU A 176
THR A 177
THR A 178
 None
None
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.3A)
AZI  A 305 (-4.2A)
AZI  A 305 (-3.4A)
AZI  A 305 ( 4.2A)
 1.13A 6bc9A-1kopA:
29.8		 6bc9A-1kopA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae) 		PF00194
(Carb_anhydrase) 		7 TRP A   7
HIS A  92
LEU A 176
THR A 177
THR A 178
PRO A 180
TRP A 187
 None
ZN  A 301 ( 3.2A)
AZI  A 305 (-4.2A)
AZI  A 305 (-3.4A)
AZI  A 305 ( 4.2A)
None
None
 1.34A 6bc9A-1kopA:
29.8		 6bc9A-1kopA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae) 		PF00194
(Carb_anhydrase) 		6 TRP A   7
HIS A  94
VAL A 123
LEU A 176
THR A 178
PRO A 180
 None
ZN  A 301 ( 3.3A)
None
AZI  A 305 (-4.2A)
AZI  A 305 ( 4.2A)
None
 1.24A 6bc9A-1kopA:
29.8		 6bc9A-1kopA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		11 TRP A   5
ASN A  62
GLN A  92
HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 199
THR A 200
PRO A 202
TRP A 209
 None
None
AZM  A 400 (-4.3A)
ZN  A 601 ( 3.3A)
ZN  A 601 (-3.3A)
AZM  A 400 (-4.8A)
AZM  A 400 (-3.7A)
AZM  A 400 (-3.6A)
AZM  A 400 (-3.6A)
None
None
 0.66A 6bc9A-1rj6A:
37.1		 6bc9A-1rj6A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		7 TRP A   5
GLN A  67
HIS A  94
HIS A  96
LEU A 198
THR A 199
THR A 200
 None
None
ZN  A 601 ( 3.3A)
ZN  A 601 (-3.3A)
AZM  A 400 (-3.7A)
AZM  A 400 (-3.6A)
AZM  A 400 (-3.6A)
 1.10A 6bc9A-1rj6A:
37.1		 6bc9A-1rj6A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		7 TRP A   5
HIS A  94
LEU A 198
THR A 199
THR A 200
PRO A 202
TRP A 209
 None
ZN  A 601 ( 3.3A)
AZM  A 400 (-3.7A)
AZM  A 400 (-3.6A)
AZM  A 400 (-3.6A)
None
None
 1.39A 6bc9A-1rj6A:
37.1		 6bc9A-1rj6A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urt CARBONIC ANHYDRASE V

(Mus musculus) 		PF00194
(Carb_anhydrase) 		9 GLN A  92
HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 199
THR A 200
PRO A 202
TRP A 209
 None
ZN  A 280 (-3.2A)
ZN  A 280 (-3.2A)
None
None
ZN  A 280 ( 4.9A)
None
None
None
 0.40A 6bc9A-1urtA:
37.0		 6bc9A-1urtA:
26.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urt CARBONIC ANHYDRASE V

(Mus musculus) 		PF00194
(Carb_anhydrase) 		6 HIS A  96
VAL A 143
LEU A 198
THR A 199
THR A 200
PRO A 202
 ZN  A 280 (-3.2A)
None
None
ZN  A 280 ( 4.9A)
None
None
 0.93A 6bc9A-1urtA:
37.0		 6bc9A-1urtA:
26.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7w HALOTOLERANT
ALPHA-TYPE CARBONIC
ANHYDRASE (DCA II)

(Dunaliella
salina) 		PF00194
(Carb_anhydrase) 		8 GLN A 113
HIS A 115
HIS A 117
VAL A 137
LEU A 216
THR A 217
THR A 218
TRP A 227
 None
ZN  A 283 ( 3.2A)
ZN  A 283 (-3.2A)
ACY  A 279 ( 4.7A)
ACY  A 279 (-4.3A)
ACY  A 279 (-3.4A)
ACY  A 279 ( 4.9A)
None
 0.20A 6bc9A-1y7wA:
26.2		 6bc9A-1y7wA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2it4 CARBONIC ANHYDRASE 1

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		8 TRP A   5
GLN A  92
HIS A  94
HIS A  96
LEU A 198
THR A 199
PRO A 202
TRP A 209
 None
None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
None
 0.49A 6bc9A-2it4A:
40.9		 6bc9A-2it4A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2it4 CARBONIC ANHYDRASE 1

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 TRP A   5
HIS A  96
VAL A 143
LEU A 198
THR A 199
PRO A 202
 None
ZN  A 561 ( 3.2A)
PPF  A 500 (-4.9A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 1.16A 6bc9A-2it4A:
40.9		 6bc9A-2it4A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2j CARBONIC
ANHYDRASE-RELATED
PROTEIN

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 TRP A  29
HIS A 118
LEU A 222
THR A 223
PRO A 226
TRP A 233
 None
CL  A 401 (-4.2A)
None
CL  A 401 ( 4.8A)
None
None
 0.38A 6bc9A-2w2jA:
37.3		 6bc9A-2w2jA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2znc CARBONIC ANHYDRASE
IV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		6 HIS A 119
HIS A  96
VAL A 143
LEU A 198
THR A 199
THR A 200
 ZN  A   1 ( 3.2A)
ZN  A   1 ( 3.3A)
None
None
ZN  A   1 ( 4.7A)
None
 1.34A 6bc9A-2zncA:
32.4		 6bc9A-2zncA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2znc CARBONIC ANHYDRASE
IV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		10 TRP A   5
ASN A  62
GLN A  92
HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 199
THR A 200
TRP A 209
 None
None
None
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
None
None
ZN  A   1 ( 4.7A)
None
None
 0.38A 6bc9A-2zncA:
32.4		 6bc9A-2zncA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2znc CARBONIC ANHYDRASE
IV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		6 TRP A   5
HIS A  96
VAL A 143
LEU A 198
THR A 199
THR A 200
 None
ZN  A   1 ( 3.3A)
None
None
ZN  A   1 ( 4.7A)
None
 1.14A 6bc9A-2zncA:
32.4		 6bc9A-2zncA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2znc CARBONIC ANHYDRASE
IV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		8 TRP A  16
HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 199
THR A 200
TRP A 209
 None
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
None
None
ZN  A   1 ( 4.7A)
None
None
 1.43A 6bc9A-2zncA:
32.4		 6bc9A-2zncA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		11 TRP A  40
ASN A 110
GLN A 161
HIS A 163
HIS A 165
VAL A 184
LEU A 259
THR A 260
THR A 261
PRO A 263
TRP A 270
 None
None
None
ZN  A 378 (-3.2A)
ZN  A 378 (-3.3A)
None
None
ZN  A 378 ( 4.5A)
None
None
None
 0.44A 6bc9A-3b1bA:
25.0		 6bc9A-3b1bA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		7 TRP A  40
GLN A 115
HIS A 163
HIS A 165
LEU A 259
THR A 260
THR A 261
 None
None
ZN  A 378 (-3.2A)
ZN  A 378 (-3.3A)
None
ZN  A 378 ( 4.5A)
None
 1.07A 6bc9A-3b1bA:
25.0		 6bc9A-3b1bA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		7 TRP A  40
HIS A 163
LEU A 259
THR A 260
THR A 261
PRO A 263
TRP A 270
 None
ZN  A 378 (-3.2A)
None
ZN  A 378 ( 4.5A)
None
None
None
 1.22A 6bc9A-3b1bA:
25.0		 6bc9A-3b1bA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		6 TRP A  40
HIS A 165
VAL A 201
LEU A 259
THR A 261
PRO A 263
 None
ZN  A 378 (-3.3A)
None
None
None
None
 1.22A 6bc9A-3b1bA:
25.0		 6bc9A-3b1bA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		7 TRP A  49
HIS A 163
HIS A 165
VAL A 184
LEU A 259
THR A 261
TRP A 270
 None
ZN  A 378 (-3.2A)
ZN  A 378 (-3.3A)
None
None
None
None
 1.50A 6bc9A-3b1bA:
25.0		 6bc9A-3b1bA:
11.83
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3da2 CARBONIC ANHYDRASE
13

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 ASN A  68
HIS A  97
LEU A 199
THR A 200
PRO A 203
TRP A 210
 None
ZN  A 301 ( 3.5A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
4MD  A 401 ( 4.9A)
None
 1.13A 6bc9A-3da2A:
42.4		 6bc9A-3da2A:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3da2 CARBONIC ANHYDRASE
13

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		8 TRP A   6
GLN A  93
HIS A  95
HIS A  97
VAL A 122
LEU A 199
THR A 200
PRO A 203
 None
4MD  A 401 (-3.1A)
ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.5A)
4MD  A 401 ( 4.6A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
4MD  A 401 ( 4.9A)
 0.85A 6bc9A-3da2A:
42.4		 6bc9A-3da2A:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3da2 CARBONIC ANHYDRASE
13

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		8 TRP A   6
GLN A  93
HIS A  97
VAL A 122
PHE A 132
LEU A 199
THR A 200
PRO A 203
 None
4MD  A 401 (-3.1A)
ZN  A 301 ( 3.5A)
4MD  A 401 ( 4.6A)
4MD  A 401 (-4.6A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
4MD  A 401 ( 4.9A)
 0.83A 6bc9A-3da2A:
42.4		 6bc9A-3da2A:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3da2 CARBONIC ANHYDRASE
13

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		8 TRP A   6
HIS A  95
HIS A  97
VAL A 122
LEU A 199
THR A 200
PRO A 203
TRP A 210
 None
ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.5A)
4MD  A 401 ( 4.6A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
4MD  A 401 ( 4.9A)
None
 0.45A 6bc9A-3da2A:
42.4		 6bc9A-3da2A:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3da2 CARBONIC ANHYDRASE
13

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		8 TRP A   6
HIS A  97
VAL A 122
PHE A 132
LEU A 199
THR A 200
PRO A 203
TRP A 210
 None
ZN  A 301 ( 3.5A)
4MD  A 401 ( 4.6A)
4MD  A 401 (-4.6A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
4MD  A 401 ( 4.9A)
None
 0.33A 6bc9A-3da2A:
42.4		 6bc9A-3da2A:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3da2 CARBONIC ANHYDRASE
13

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 TRP A  17
HIS A  95
HIS A  97
VAL A 122
LEU A 199
THR A 200
TRP A 210
 None
ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.5A)
4MD  A 401 ( 4.6A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
None
 1.48A 6bc9A-3da2A:
42.4		 6bc9A-3da2A:
30.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe4 CARBONIC ANHYDRASE 6

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		8 ASN A  83
GLN A 109
HIS A 111
HIS A 113
VAL A 140
LEU A 219
THR A 220
TRP A 230
 None
None
MG  A 901 (-3.4A)
MG  A 901 (-3.4A)
None
None
None
None
 0.69A 6bc9A-3fe4A:
31.6		 6bc9A-3fe4A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jxf RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 TRP A  38
HIS A 129
LEU A 235
THR A 236
PRO A 239
TRP A 246
 None
 0.48A 6bc9A-3jxfA:
33.5		 6bc9A-3jxfA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 GLN A  92
HIS A  94
HIS A  96
VAL A 121
PHE A 131
LEU A 198
THR A 199
 AZM  A 264 (-4.1A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
AZM  A 264 (-4.7A)
AZM  A 264 (-4.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
 1.38A 6bc9A-3ml5A:
43.0		 6bc9A-3ml5A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		12 TRP A   5
ASN A  62
GLN A  92
HIS A  94
HIS A  96
VAL A 121
PHE A 131
LEU A 198
THR A 199
THR A 200
PRO A 202
TRP A 209
 None
None
AZM  A 264 (-4.1A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
AZM  A 264 (-4.7A)
AZM  A 264 (-4.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
None
None
 0.48A 6bc9A-3ml5A:
43.0		 6bc9A-3ml5A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		8 TRP A   5
GLN A  67
HIS A  94
HIS A  96
LEU A 198
THR A 199
THR A 200
PRO A 202
 None
None
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
None
 1.10A 6bc9A-3ml5A:
43.0		 6bc9A-3ml5A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 TRP A   5
HIS A  94
LEU A 198
THR A 199
THR A 200
PRO A 202
TRP A 209
 None
ZN  A 263 ( 3.2A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
None
None
 1.32A 6bc9A-3ml5A:
43.0		 6bc9A-3ml5A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 TRP A   5
HIS A  96
VAL A 143
LEU A 198
THR A 200
PRO A 202
 None
ZN  A 263 ( 3.2A)
AZM  A 264 ( 4.9A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
None
 1.02A 6bc9A-3ml5A:
43.0		 6bc9A-3ml5A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 TRP A  16
HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 200
TRP A 209
 None
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
AZM  A 264 (-4.7A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
None
 1.46A 6bc9A-3ml5A:
43.0		 6bc9A-3ml5A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q31 CARBONIC ANHYDRASE

(Aspergillus
oryzae) 		PF00194
(Carb_anhydrase) 		9 GLN A 121
HIS A 123
HIS A 125
VAL A 144
LEU A 214
THR A 215
THR A 216
PRO A 218
TRP A 225
 MLT  A   3 (-3.9A)
ZN  A   1 ( 3.2A)
ZN  A   1 (-3.3A)
None
MLT  A   3 ( 4.2A)
MLT  A   3 ( 4.3A)
MLT  A   3 (-2.8A)
None
MLT  A   3 (-4.9A)
 0.51A 6bc9A-3q31A:
24.3		 6bc9A-3q31A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q31 CARBONIC ANHYDRASE

(Aspergillus
oryzae) 		PF00194
(Carb_anhydrase) 		7 TRP A  48
HIS A 123
HIS A 125
VAL A 144
LEU A 214
THR A 216
TRP A 225
 None
ZN  A   1 ( 3.2A)
ZN  A   1 (-3.3A)
None
MLT  A   3 ( 4.2A)
MLT  A   3 (-2.8A)
MLT  A   3 (-4.9A)
 1.34A 6bc9A-3q31A:
24.3		 6bc9A-3q31A:
15.23
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uyq CARBONIC ANHYDRASE 3

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 GLN A  92
HIS A  94
HIS A  96
VAL A 121
PHE A 130
THR A 198
 None
ZN  A 261 (-3.3A)
ZN  A 261 (-3.3A)
None
None
ZN  A 261 ( 4.4A)
 1.22A 6bc9A-3uyqA:
41.3		 6bc9A-3uyqA:
32.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uyq CARBONIC ANHYDRASE 3

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		10 TRP A   5
ASN A  62
GLN A  92
HIS A  94
HIS A  96
VAL A 121
PHE A 130
THR A 198
THR A 199
PRO A 201
 None
None
None
ZN  A 261 (-3.3A)
ZN  A 261 (-3.3A)
None
None
ZN  A 261 ( 4.4A)
None
None
 0.56A 6bc9A-3uyqA:
41.3		 6bc9A-3uyqA:
32.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uyq CARBONIC ANHYDRASE 3

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		10 TRP A   5
ASN A  62
GLN A  92
HIS A  94
HIS A  96
VAL A 121
PHE A 130
THR A 198
THR A 199
TRP A 208
 None
None
None
ZN  A 261 (-3.3A)
ZN  A 261 (-3.3A)
None
None
ZN  A 261 ( 4.4A)
None
None
 0.50A 6bc9A-3uyqA:
41.3		 6bc9A-3uyqA:
32.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		11 TRP A   3
ASN A  62
GLN A  87
HIS A  89
HIS A  91
VAL A 110
LEU A 173
THR A 174
THR A 175
PRO A 177
TRP A 184
 None
None
AZM  A 302 (-4.4A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
AZM  A 302 (-4.7A)
AZM  A 302 (-3.8A)
AZM  A 302 (-3.4A)
AZM  A 302 (-3.4A)
None
None
 0.50A 6bc9A-4g7aA:
30.1		 6bc9A-4g7aA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		6 TRP A   3
GLN A  67
HIS A  91
LEU A 173
THR A 174
THR A 175
 None
None
ZN  A 301 ( 3.2A)
AZM  A 302 (-3.8A)
AZM  A 302 (-3.4A)
AZM  A 302 (-3.4A)
 1.17A 6bc9A-4g7aA:
30.1		 6bc9A-4g7aA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		7 TRP A   3
HIS A  89
HIS A  91
VAL A 120
LEU A 173
THR A 175
PRO A 177
 None
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
AZM  A 302 ( 4.8A)
AZM  A 302 (-3.8A)
AZM  A 302 (-3.4A)
None
 1.22A 6bc9A-4g7aA:
30.1		 6bc9A-4g7aA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		6 TRP A   3
HIS A  89
LEU A 173
THR A 175
PRO A 177
TRP A 184
 None
ZN  A 301 ( 3.2A)
AZM  A 302 (-3.8A)
AZM  A 302 (-3.4A)
None
None
 1.32A 6bc9A-4g7aA:
30.1		 6bc9A-4g7aA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		7 TRP A  14
HIS A  89
HIS A  91
VAL A 110
LEU A 173
THR A 175
TRP A 184
 None
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
AZM  A 302 (-4.7A)
AZM  A 302 (-3.8A)
AZM  A 302 (-3.4A)
None
 1.50A 6bc9A-4g7aA:
30.1		 6bc9A-4g7aA:
17.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 ASN A  67
HIS A  96
LEU A 198
THR A 199
THR A 200
PRO A 202
 None
ZN  A 301 (-3.2A)
None
ZN  A 301 ( 4.4A)
None
None
 1.05A 6bc9A-4qk3A:
43.8		 6bc9A-4qk3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 ASN A  67
HIS A  96
VAL A 143
LEU A 198
THR A 200
PRO A 202
 None
ZN  A 301 (-3.2A)
None
None
None
None
 1.03A 6bc9A-4qk3A:
43.8		 6bc9A-4qk3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 GLN A  92
HIS A  94
HIS A  96
VAL A 121
PHE A 131
LEU A 198
THR A 199
 None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
None
None
None
ZN  A 301 ( 4.4A)
 1.39A 6bc9A-4qk3A:
43.8		 6bc9A-4qk3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		12 TRP A   5
ASN A  62
GLN A  92
HIS A  94
HIS A  96
VAL A 121
PHE A 131
LEU A 198
THR A 199
THR A 200
PRO A 202
TRP A 209
 None
None
None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
None
None
None
ZN  A 301 ( 4.4A)
None
None
None
 0.31A 6bc9A-4qk3A:
43.8		 6bc9A-4qk3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 TRP A   5
HIS A  94
LEU A 198
THR A 199
THR A 200
PRO A 202
TRP A 209
 None
ZN  A 301 (-3.2A)
None
ZN  A 301 ( 4.4A)
None
None
None
 1.27A 6bc9A-4qk3A:
43.8		 6bc9A-4qk3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 TRP A   5
HIS A  96
VAL A 143
LEU A 198
THR A 200
PRO A 202
 None
ZN  A 301 (-3.2A)
None
None
None
None
 1.18A 6bc9A-4qk3A:
43.8		 6bc9A-4qk3A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uov CARBONATE
DEHYDRATASE

(Thermovibrio
ammonificans) 		PF00194
(Carb_anhydrase) 		10 TRP A  26
ASN A  85
GLN A 110
HIS A 112
HIS A 114
VAL A 133
LEU A 197
THR A 198
THR A 199
TRP A 208
 None
None
CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.38A 6bc9A-4uovA:
31.3		 6bc9A-4uovA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uov CARBONATE
DEHYDRATASE

(Thermovibrio
ammonificans) 		PF00194
(Carb_anhydrase) 		10 TRP A  26
GLN A 110
HIS A 112
HIS A 114
VAL A 133
LEU A 197
THR A 198
THR A 199
PRO A 201
TRP A 208
 None
CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
None
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
None
 0.54A 6bc9A-4uovA:
31.3		 6bc9A-4uovA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uov CARBONATE
DEHYDRATASE

(Thermovibrio
ammonificans) 		PF00194
(Carb_anhydrase) 		7 TRP A  26
HIS A 112
HIS A 114
VAL A 143
LEU A 197
THR A 199
PRO A 201
 None
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 ( 4.8A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
 1.30A 6bc9A-4uovA:
31.3		 6bc9A-4uovA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uov CARBONATE
DEHYDRATASE

(Thermovibrio
ammonificans) 		PF00194
(Carb_anhydrase) 		6 TRP A  26
HIS A 112
LEU A 197
THR A 199
PRO A 201
TRP A 208
 None
ZN  A 298 (-3.2A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
None
None
 1.31A 6bc9A-4uovA:
31.3		 6bc9A-4uovA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uov CARBONATE
DEHYDRATASE

(Thermovibrio
ammonificans) 		PF00194
(Carb_anhydrase) 		6 TRP A  26
HIS A 114
LEU A 197
THR A 198
THR A 199
TRP A 208
 None
ZN  A 298 ( 3.2A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 1.23A 6bc9A-4uovA:
31.3		 6bc9A-4uovA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)

(Sulfurihydrogenibium
azorense) 		PF00194
(Carb_anhydrase) 		11 TRP A   3
ASN A  62
GLN A  87
HIS A  89
HIS A  91
VAL A 110
LEU A 173
THR A 174
THR A 175
PRO A 177
TRP A 184
 None
None
AZM  A 302 (-4.3A)
ZN  A 301 ( 3.1A)
ZN  A 301 ( 3.2A)
AZM  A 302 (-4.8A)
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
AZM  A 302 (-3.3A)
None
None
 0.50A 6bc9A-4x5sA:
30.0		 6bc9A-4x5sA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)

(Sulfurihydrogenibium
azorense) 		PF00194
(Carb_anhydrase) 		6 TRP A   3
GLN A  67
HIS A  91
LEU A 173
THR A 174
THR A 175
 None
None
ZN  A 301 ( 3.2A)
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
AZM  A 302 (-3.3A)
 1.12A 6bc9A-4x5sA:
30.0		 6bc9A-4x5sA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)

(Sulfurihydrogenibium
azorense) 		PF00194
(Carb_anhydrase) 		7 TRP A   3
HIS A  89
HIS A  91
VAL A 120
LEU A 173
THR A 175
PRO A 177
 None
ZN  A 301 ( 3.1A)
ZN  A 301 ( 3.2A)
AZM  A 302 ( 4.8A)
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
None
 1.26A 6bc9A-4x5sA:
30.0		 6bc9A-4x5sA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)

(Sulfurihydrogenibium
azorense) 		PF00194
(Carb_anhydrase) 		7 TRP A   3
HIS A  89
LEU A 173
THR A 174
THR A 175
PRO A 177
TRP A 184
 None
ZN  A 301 ( 3.1A)
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
AZM  A 302 (-3.3A)
None
None
 1.34A 6bc9A-4x5sA:
30.0		 6bc9A-4x5sA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfw ALPHA-CARBONIC
ANHYDRASE

(Helicobacter
pylori) 		PF00194
(Carb_anhydrase) 		8 TRP A  23
HIS A 110
HIS A 112
VAL A 131
LEU A 190
THR A 191
PRO A 194
TRP A 201
 None
ZN  A 301 (-3.3A)
ZN  A 301 (-3.4A)
None
None
ZN  A 301 (-4.3A)
None
None
 0.51A 6bc9A-4xfwA:
26.5		 6bc9A-4xfwA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfw ALPHA-CARBONIC
ANHYDRASE

(Helicobacter
pylori) 		PF00194
(Carb_anhydrase) 		7 TRP A  35
HIS A 110
HIS A 112
VAL A 131
LEU A 190
THR A 191
TRP A 201
 None
ZN  A 301 (-3.3A)
ZN  A 301 (-3.4A)
None
None
ZN  A 301 (-4.3A)
None
 1.28A 6bc9A-4xfwA:
26.5		 6bc9A-4xfwA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		9 GLN A 158
HIS A 160
HIS A 162
VAL A 181
LEU A 253
THR A 254
THR A 255
PRO A 257
TRP A 264
 None
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.2A)
None
2HP  A 402 (-3.4A)
2HP  A 402 (-2.9A)
2HP  A 402 (-3.6A)
None
None
 0.44A 6bc9A-4xixA:
25.8		 6bc9A-4xixA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		8 TRP A  86
HIS A 160
HIS A 162
VAL A 181
LEU A 253
THR A 254
THR A 255
TRP A 264
 None
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.2A)
None
2HP  A 402 (-3.4A)
2HP  A 402 (-2.9A)
2HP  A 402 (-3.6A)
None
 1.47A 6bc9A-4xixA:
25.8		 6bc9A-4xixA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		11 TRP A  78
ASN A 138
GLN A 163
HIS A 165
HIS A 167
VAL A 186
LEU A 251
THR A 252
THR A 253
PRO A 255
TRP A 262
 None
None
None
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.3A)
None
BCT  A 402 (-3.8A)
BCT  A 402 (-3.7A)
BCT  A 402 ( 4.4A)
None
None
 0.45A 6bc9A-4xz5A:
29.8		 6bc9A-4xz5A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		6 TRP A  78
HIS A 165
LEU A 251
THR A 253
PRO A 255
TRP A 262
 None
ZN  A 401 ( 3.2A)
BCT  A 402 (-3.8A)
BCT  A 402 ( 4.4A)
None
None
 1.22A 6bc9A-4xz5A:
29.8		 6bc9A-4xz5A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		6 TRP A  78
HIS A 167
LEU A 251
THR A 252
THR A 253
TRP A 262
 None
ZN  A 401 ( 3.3A)
BCT  A 402 (-3.8A)
BCT  A 402 (-3.7A)
BCT  A 402 ( 4.4A)
None
 1.25A 6bc9A-4xz5A:
29.8		 6bc9A-4xz5A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		7 TRP A  78
HIS A 167
VAL A 196
LEU A 251
THR A 252
THR A 253
PRO A 255
 None
ZN  A 401 ( 3.3A)
None
BCT  A 402 (-3.8A)
BCT  A 402 (-3.7A)
BCT  A 402 ( 4.4A)
None
 1.14A 6bc9A-4xz5A:
29.8		 6bc9A-4xz5A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		7 TRP A  89
HIS A 165
HIS A 167
VAL A 186
LEU A 251
THR A 253
TRP A 262
 None
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.3A)
None
BCT  A 402 (-3.8A)
BCT  A 402 ( 4.4A)
None
 1.46A 6bc9A-4xz5A:
29.8		 6bc9A-4xz5A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		11 TRP A   5
ASN A  62
GLN A  92
HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 199
THR A 200
PRO A 202
TRP A 209
 None
GOL  A 303 (-3.9A)
GOL  A 303 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
None
None
 0.46A 6bc9A-5cjfA:
36.8		 6bc9A-5cjfA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 TRP A   5
GLN A  67
HIS A  94
HIS A  96
LEU A 198
THR A 199
THR A 200
 None
GOL  A 303 (-3.4A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
 1.15A 6bc9A-5cjfA:
36.8		 6bc9A-5cjfA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 TRP A   5
HIS A  94
LEU A 198
THR A 200
PRO A 202
TRP A 209
 None
ZN  A 301 (-3.2A)
520  A 302 (-3.6A)
GOL  A 303 ( 3.5A)
None
None
 1.30A 6bc9A-5cjfA:
36.8		 6bc9A-5cjfA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 TRP A   5
HIS A  96
VAL A 143
LEU A 198
THR A 199
THR A 200
 None
ZN  A 301 ( 3.2A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
 1.08A 6bc9A-5cjfA:
36.8		 6bc9A-5cjfA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		9 TRP A  16
HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 199
THR A 200
PRO A 202
TRP A 209
 None
ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
520  A 302 ( 4.9A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
None
None
 1.44A 6bc9A-5cjfA:
36.8		 6bc9A-5cjfA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e5u RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE GAMMA

(Mus musculus) 		PF00194
(Carb_anhydrase) 		8 TRP A  60
HIS A 151
PHE A 187
LEU A 256
THR A 257
THR A 258
PRO A 260
TRP A 267
 None
 0.89A 6bc9A-5e5uA:
34.2		 6bc9A-5e5uA:
14.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		6 ASN X  66
HIS X  95
LEU X 196
THR X 197
THR X 198
PRO X 200
 None
ZN  X 301 (-3.2A)
None
ZN  X 301 ( 4.4A)
None
None
 1.10A 6bc9A-5eztX:
44.2		 6bc9A-5eztX:
77.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		6 ASN X  66
HIS X  95
VAL X 141
LEU X 196
THR X 198
PRO X 200
 None
ZN  X 301 (-3.2A)
None
None
None
None
 1.06A 6bc9A-5eztX:
44.2		 6bc9A-5eztX:
77.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		7 GLN X  91
HIS X  93
HIS X  95
VAL X 120
PHE X 129
LEU X 196
THR X 197
 None
ZN  X 301 (-3.2A)
ZN  X 301 (-3.2A)
None
None
None
ZN  X 301 ( 4.4A)
 1.44A 6bc9A-5eztX:
44.2		 6bc9A-5eztX:
77.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		12 TRP X   4
ASN X  61
GLN X  91
HIS X  93
HIS X  95
VAL X 120
PHE X 129
LEU X 196
THR X 197
THR X 198
PRO X 200
TRP X 207
 None
None
None
ZN  X 301 (-3.2A)
ZN  X 301 (-3.2A)
None
None
None
ZN  X 301 ( 4.4A)
None
None
None
 0.35A 6bc9A-5eztX:
44.2		 6bc9A-5eztX:
77.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		7 TRP X   4
HIS X  93
LEU X 196
THR X 197
THR X 198
PRO X 200
TRP X 207
 None
ZN  X 301 (-3.2A)
None
ZN  X 301 ( 4.4A)
None
None
None
 1.35A 6bc9A-5eztX:
44.2		 6bc9A-5eztX:
77.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		6 TRP X   4
HIS X  95
VAL X 141
LEU X 196
THR X 198
PRO X 200
 None
ZN  X 301 (-3.2A)
None
None
None
None
 1.20A 6bc9A-5eztX:
44.2		 6bc9A-5eztX:
77.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		11 TRP A  15
ASN A  69
GLN A  94
HIS A  96
HIS A  98
VAL A 117
LEU A 181
THR A 182
THR A 183
PRO A 185
TRP A 192
 None
None
None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
None
None
ZN  A 301 ( 4.4A)
None
None
None
 0.55A 6bc9A-5hpjA:
29.4		 6bc9A-5hpjA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		7 TRP A  15
HIS A  96
LEU A 181
THR A 182
THR A 183
PRO A 185
TRP A 192
 None
ZN  A 301 (-3.2A)
None
ZN  A 301 ( 4.4A)
None
None
None
 1.29A 6bc9A-5hpjA:
29.4		 6bc9A-5hpjA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		6 TRP A  15
HIS A  98
VAL A 127
LEU A 181
THR A 183
PRO A 185
 None
ZN  A 301 (-3.2A)
None
None
None
None
 1.07A 6bc9A-5hpjA:
29.4		 6bc9A-5hpjA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		7 TRP A  26
HIS A  96
HIS A  98
VAL A 117
LEU A 181
THR A 183
TRP A 192
 None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
None
None
None
None
 1.39A 6bc9A-5hpjA:
29.4		 6bc9A-5hpjA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jn9 CARBONIC ANHYDRASE 4

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		10 TRP A   5
ASN A  62
GLN A  92
HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 199
THR A 200
TRP A 209
 None
None
EZL  A 302 (-4.3A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
EZL  A 302 (-4.7A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.4A)
EZL  A 302 (-3.9A)
None
 0.42A 6bc9A-5jn9A:
33.5		 6bc9A-5jn9A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jn9 CARBONIC ANHYDRASE 4

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 TRP A   5
HIS A  94
HIS A  96
VAL A 143
LEU A 198
THR A 200
 None
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
EZL  A 302 ( 4.7A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.9A)
 1.34A 6bc9A-5jn9A:
33.5		 6bc9A-5jn9A:
13.58
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6eki CARBONIC ANHYDRASE

(Persephonella
marina) 		no annotation 11 TRP A  33
ASN A  90
GLN A 115
HIS A 117
HIS A 119
VAL A 138
LEU A 201
THR A 202
THR A 203
PRO A 205
TRP A 212
 None
None
None
ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
None
None
ZN  A 301 (-4.4A)
None
None
None
 0.56A 6bc9A-6ekiA:
30.0		 6bc9A-6ekiA:
32.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6eki CARBONIC ANHYDRASE

(Persephonella
marina) 		no annotation 6 TRP A  33
HIS A 117
LEU A 201
THR A 203
PRO A 205
TRP A 212
 None
ZN  A 301 (-3.3A)
None
None
None
None
 1.35A 6bc9A-6ekiA:
30.0		 6bc9A-6ekiA:
32.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6eki CARBONIC ANHYDRASE

(Persephonella
marina) 		no annotation 6 TRP A  33
HIS A 119
VAL A 148
LEU A 201
THR A 203
PRO A 205
 None
ZN  A 301 (-3.3A)
None
None
None
None
 1.21A 6bc9A-6ekiA:
30.0		 6bc9A-6ekiA:
32.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6eki CARBONIC ANHYDRASE

(Persephonella
marina) 		no annotation 7 TRP A  44
HIS A 117
HIS A 119
VAL A 138
LEU A 201
THR A 203
TRP A 212
 None
ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
None
None
None
None
 1.45A 6bc9A-6ekiA:
30.0		 6bc9A-6ekiA:
32.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6fe1 CARBONIC ANHYDRASE 9

(Homo sapiens) 		no annotation 6 ASN A  62
HIS A  94
HIS A  96
THR A 199
PRO A 201
TRP A 209
 V14  A 302 (-3.4A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
V14  A 302 (-3.2A)
None
None
 1.24A 6bc9A-6fe1A:
33.9		 6bc9A-6fe1A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6fe1 CARBONIC ANHYDRASE 9

(Homo sapiens) 		no annotation 11 TRP A   5
ASN A  62
GLN A  92
HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 199
THR A 200
PRO A 202
TRP A 209
 None
V14  A 302 (-3.4A)
V14  A 302 (-3.8A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
V14  A 302 (-4.7A)
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
V14  A 302 (-3.5A)
None
None
 0.51A 6bc9A-6fe1A:
33.9		 6bc9A-6fe1A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6fe1 CARBONIC ANHYDRASE 9

(Homo sapiens) 		no annotation 8 TRP A   5
HIS A  94
HIS A  96
VAL A 143
LEU A 198
THR A 199
THR A 200
PRO A 202
 None
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
None
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
V14  A 302 (-3.5A)
None
 1.10A 6bc9A-6fe1A:
33.9		 6bc9A-6fe1A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6fe1 CARBONIC ANHYDRASE 9

(Homo sapiens) 		no annotation 6 TRP A   5
HIS A  94
LEU A 198
THR A 200
PRO A 202
TRP A 209
 None
ZN  A 301 ( 3.2A)
V14  A 302 (-3.6A)
V14  A 302 (-3.5A)
None
None
 1.34A 6bc9A-6fe1A:
33.9		 6bc9A-6fe1A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6fe1 CARBONIC ANHYDRASE 9

(Homo sapiens) 		no annotation 6 TRP A   5
HIS A  96
LEU A 198
THR A 199
THR A 200
TRP A 209
 None
ZN  A 301 ( 3.2A)
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
V14  A 302 (-3.5A)
None
 1.21A 6bc9A-6fe1A:
33.9		 6bc9A-6fe1A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6fe1 CARBONIC ANHYDRASE 9

(Homo sapiens) 		no annotation 7 TRP A  16
HIS A  94
HIS A  96
VAL A 121
LEU A 198
THR A 200
TRP A 209
 None
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
V14  A 302 (-4.7A)
V14  A 302 (-3.6A)
V14  A 302 (-3.5A)
None
 1.46A 6bc9A-6fe1A:
33.9		 6bc9A-6fe1A:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1e5f METHIONINE
GAMMA-LYASE

(Trichomonas
vaginalis) 		PF01053
(Cys_Met_Meta_PP) 		4 HIS A 354
GLU A 361
LEU A 122
VAL A 129
 None
 1.21A 6bc9A-1e5fA:
undetectable		 6bc9A-1e5fA:
11.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ixx COAGULATION FACTORS
IX/X-BINDING PROTEIN

(Protobothrops
flavoviridis) 		PF00059
(Lectin_C) 		4 HIS A  38
GLU A  43
LEU A  54
VAL A  51
 None
CA  A 130 ( 3.5A)
None
None
 1.20A 6bc9A-1ixxA:
undetectable		 6bc9A-1ixxA:
19.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jd0 CARBONIC ANHYDRASE
XII

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 HIS A  64
GLU A 106
HIS A 119
LEU A 141
VAL A 143
 None
ZN  A 901 ( 4.5A)
ZN  A 901 ( 3.1A)
None
AZM  A1400 ( 4.9A)
 0.21A 6bc9A-1jd0A:
36.7		 6bc9A-1jd0A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kkr 3-METHYLASPARTATE
AMMONIA-LYASE

(Citrobacter
amalonaticus) 		PF05034
(MAAL_N)
PF07476
(MAAL_C) 		4 HIS A 326
GLU A 262
LEU A 211
VAL A 215
 None
 1.11A 6bc9A-1kkrA:
undetectable		 6bc9A-1kkrA:
13.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae) 		PF00194
(Carb_anhydrase) 		4 HIS A  66
GLU A  98
HIS A 111
VAL A 123
 BME  A 303 (-3.6A)
ZN  A 301 ( 4.6A)
ZN  A 301 ( 3.2A)
None
 0.14A 6bc9A-1kopA:
29.8		 6bc9A-1kopA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1lla HEMOCYANIN (SUBUNIT
TYPE II)

(Limulus
polyphemus) 		PF00372
(Hemocyanin_M)
PF03722
(Hemocyanin_N)
PF03723
(Hemocyanin_C) 		4 HIS A 399
HIS A 438
LEU A 463
VAL A 544
 None
 1.05A 6bc9A-1llaA:
undetectable		 6bc9A-1llaA:
9.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1or4 HEME-BASED
AEROTACTIC
TRANSDUCER HEMAT

(Bacillus
subtilis) 		PF11563
(Protoglobin) 		4 GLU A 114
HIS A  31
LEU A  38
VAL A  34
 None
 1.14A 6bc9A-1or4A:
undetectable		 6bc9A-1or4A:
17.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		5 HIS A  64
GLU A 106
HIS A 119
LEU A 141
VAL A 143
 None
ZN  A 601 ( 4.5A)
ZN  A 601 ( 3.2A)
None
None
 0.38A 6bc9A-1rj6A:
37.1		 6bc9A-1rj6A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rkx CDP-GLUCOSE-4,6-DEHY
DRATASE

(Yersinia
pseudotuberculosis) 		PF16363
(GDP_Man_Dehyd) 		4 HIS A 333
GLU A 349
HIS A 234
LEU A 322
 None
 0.93A 6bc9A-1rkxA:
undetectable		 6bc9A-1rkxA:
10.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1s1g POTASSIUM
VOLTAGE-GATED
CHANNEL SUBFAMILY D
MEMBER 3

(Homo sapiens) 		PF02214
(BTB_2) 		4 HIS A 104
GLU A  89
LEU A  44
VAL A  46
 ZN  A 152 (-3.3A)
None
None
None
 1.10A 6bc9A-1s1gA:
undetectable		 6bc9A-1s1gA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urt CARBONIC ANHYDRASE V

(Mus musculus) 		PF00194
(Carb_anhydrase) 		4 GLU A 106
HIS A 119
LEU A 141
VAL A 143
 ZN  A 280 ( 4.7A)
ZN  A 280 (-3.2A)
None
None
 0.30A 6bc9A-1urtA:
37.0		 6bc9A-1urtA:
26.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wu8 HYPOTHETICAL PROTEIN
PH0463

(Pyrococcus
horikoshii) 		PF01887
(SAM_adeno_trans) 		4 HIS A 227
GLU A 189
LEU A 160
VAL A 162
 None
 1.19A 6bc9A-1wu8A:
undetectable		 6bc9A-1wu8A:
13.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1wvg CDP-GLUCOSE
4,6-DEHYDRATASE

(Salmonella
enterica) 		PF16363
(GDP_Man_Dehyd) 		4 HIS A 335
GLU A 351
HIS A 236
LEU A 324
 None
 0.97A 6bc9A-1wvgA:
undetectable		 6bc9A-1wvgA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1xs5 MEMBRANE LIPOPROTEIN
TPN32

(Treponema
pallidum) 		PF03180
(Lipoprotein_9) 		4 GLU A  87
HIS A  85
LEU A 204
VAL A  84
 MET  A 301 (-2.6A)
None
None
None
 1.05A 6bc9A-1xs5A:
undetectable		 6bc9A-1xs5A:
15.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7w HALOTOLERANT
ALPHA-TYPE CARBONIC
ANHYDRASE (DCA II)

(Dunaliella
salina) 		PF00194
(Carb_anhydrase) 		4 GLU A 122
HIS A 135
LEU A 151
VAL A 153
 ZN  A 283 ( 4.5A)
ZN  A 283 ( 3.1A)
None
None
 0.16A 6bc9A-1y7wA:
26.2		 6bc9A-1y7wA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ywl HYPOTHETICAL UPF0213
PROTEIN EF2693

(Enterococcus
faecalis) 		PF01541
(GIY-YIG) 		4 GLU A  81
HIS A  55
LEU A  12
VAL A  11
 None
 1.15A 6bc9A-1ywlA:
undetectable		 6bc9A-1ywlA:
26.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2e3x COAGULATION FACTOR
X-ACTIVATING ENZYME
LIGHT CHAIN 1

(Daboia
siamensis) 		PF00059
(Lectin_C) 		4 HIS C 104
GLU C  50
LEU C  41
VAL C  42
 None
 1.18A 6bc9A-2e3xC:
undetectable		 6bc9A-2e3xC:
17.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2eb5 2-OXO-HEPT-3-ENE-1,7
-DIOATE HYDRATASE

(Escherichia
coli) 		PF01557
(FAA_hydrolase) 		4 HIS A  60
GLU A 139
LEU A 208
VAL A 207
 None
MG  A1001 ( 3.0A)
None
None
 1.20A 6bc9A-2eb5A:
undetectable		 6bc9A-2eb5A:
15.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2epj GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE

(Aeropyrum
pernix) 		PF00202
(Aminotran_3) 		4 GLU A 210
HIS A 149
LEU A 156
VAL A 155
 PMP  A 501 ( 3.9A)
None
None
None
 0.96A 6bc9A-2epjA:
undetectable		 6bc9A-2epjA:
9.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2g0w LMO2234 PROTEIN

(Listeria
monocytogenes) 		PF01261
(AP_endonuc_2) 		4 GLU A  74
HIS A 109
LEU A 169
VAL A 195
 None
 1.17A 6bc9A-2g0wA:
undetectable		 6bc9A-2g0wA:
15.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2gm8 TENA HOMOLOG/THI-4
THIAMINASE

(Pyrobaculum
aerophilum) 		PF03070
(TENA_THI-4) 		4 HIS A  -1
GLU A 140
LEU A 176
VAL A 173
 None
 1.17A 6bc9A-2gm8A:
undetectable		 6bc9A-2gm8A:
20.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2hxi PUTATIVE
TRANSCRIPTIONAL
REGULATOR

(Streptomyces
coelicolor) 		PF00440
(TetR_N)
PF02909
(TetR_C) 		4 HIS A  47
GLU A  53
LEU A  97
VAL A 100
 None
 1.19A 6bc9A-2hxiA:
undetectable		 6bc9A-2hxiA:
15.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2it4 CARBONIC ANHYDRASE 1

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 GLU A 106
HIS A 119
LEU A 141
VAL A 143
 ZN  A 561 ( 4.9A)
ZN  A 561 ( 3.1A)
None
PPF  A 500 (-4.9A)
 0.27A 6bc9A-2it4A:
40.9		 6bc9A-2it4A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2kq1 BH0266 PROTEIN

(Bacillus
halodurans) 		PF07949
(YbbR) 		4 GLU A  74
HIS A  75
LEU A  82
VAL A  84
 None
 1.01A 6bc9A-2kq1A:
undetectable		 6bc9A-2kq1A:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2lrr DNA-BINDING PROTEIN
SMUBP-2

(Homo sapiens) 		PF01424
(R3H) 		4 HIS A 753
HIS A 769
LEU A 744
VAL A 782
 None
DGP  A 801 (-4.4A)
None
None
 1.16A 6bc9A-2lrrA:
undetectable		 6bc9A-2lrrA:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ls5 UNCHARACTERIZED
PROTEIN

(Bacteroides
thetaiotaomicron) 		PF08534
(Redoxin) 		4 HIS A 157
GLU A 152
HIS A 154
VAL A 128
 None
 1.13A 6bc9A-2ls5A:
undetectable		 6bc9A-2ls5A:
21.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o1x 1-DEOXY-D-XYLULOSE-5
-PHOSPHATE SYNTHASE

(Deinococcus
radiodurans) 		PF02779
(Transket_pyr)
PF02780
(Transketolase_C)
PF13292
(DXP_synthase_N) 		4 HIS A 117
HIS A 147
LEU A 271
VAL A 275
 None
 1.13A 6bc9A-2o1xA:
undetectable		 6bc9A-2o1xA:
9.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2o36 THIMET
OLIGOPEPTIDASE

(Homo sapiens) 		PF01432
(Peptidase_M3) 		4 HIS A  87
GLU A 474
HIS A 477
VAL A 501
 None
ZN  A 690 ( 4.1A)
ZN  A 690 (-3.3A)
None
 1.14A 6bc9A-2o36A:
undetectable		 6bc9A-2o36A:
9.57
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2p6y HYPOTHETICAL PROTEIN
VCA0587

(Vibrio cholerae) 		PF03479
(DUF296) 		4 HIS A 107
HIS A 112
LEU A 127
VAL A 129
 None
 1.09A 6bc9A-2p6yA:
undetectable		 6bc9A-2p6yA:
18.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2pff FATTY ACID SYNTHASE
SUBUNIT BETA

(Saccharomyces
cerevisiae) 		PF00698
(Acyl_transf_1)
PF16073
(SAT) 		4 GLU B 172
HIS B 248
LEU B 255
VAL B 251
 None
 1.02A 6bc9A-2pffB:
undetectable		 6bc9A-2pffB:
2.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9g CYTOCHROME P450 46A1

(Homo sapiens) 		PF00067
(p450) 		4 HIS A 310
GLU A 305
HIS A 304
LEU A 204
 HEM  A 505 ( 4.6A)
None
None
None
 1.01A 6bc9A-2q9gA:
undetectable		 6bc9A-2q9gA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2q9u A-TYPE FLAVOPROTEIN

(Giardia
intestinalis) 		no annotation 4 HIS A  34
HIS A 304
LEU A 290
VAL A 289
 None
 1.09A 6bc9A-2q9uA:
undetectable		 6bc9A-2q9uA:
14.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2qne PUTATIVE
METHYLTRANSFERASE

(Desulfitobacterium
hafniense) 		PF06253
(MTTB) 		4 HIS A 345
HIS A 128
LEU A  72
VAL A  81
 EDO  A 478 (-4.7A)
None
None
None
 1.14A 6bc9A-2qneA:
undetectable		 6bc9A-2qneA:
10.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x0n GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL

(Trypanosoma
brucei) 		PF00044
(Gp_dh_N)
PF02800
(Gp_dh_C) 		4 HIS A  55
HIS A  60
LEU A  77
VAL A  79
 None
 1.04A 6bc9A-2x0nA:
undetectable		 6bc9A-2x0nA:
11.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2x7v PROBABLE
ENDONUCLEASE 4

(Thermotoga
maritima) 		PF01261
(AP_endonuc_2) 		4 HIS A 109
GLU A  94
LEU A 133
VAL A 132
 ZN  A1287 (-3.3A)
None
None
None
 1.06A 6bc9A-2x7vA:
undetectable		 6bc9A-2x7vA:
13.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2znc CARBONIC ANHYDRASE
IV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		4 HIS A  64
GLU A 106
HIS A 119
VAL A 143
 None
ZN  A   1 ( 4.8A)
ZN  A   1 ( 3.2A)
None
 0.24A 6bc9A-2zncA:
32.4		 6bc9A-2zncA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2zo4 METALLO-BETA-LACTAMA
SE FAMILY PROTEIN

(Thermus
thermophilus) 		PF00753
(Lactamase_B) 		4 HIS A 100
HIS A  92
LEU A 156
VAL A 165
 None
 1.15A 6bc9A-2zo4A:
undetectable		 6bc9A-2zo4A:
13.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		4 HIS A 112
GLU A 169
HIS A 182
VAL A 201
 None
ZN  A 378 ( 4.5A)
ZN  A 378 (-3.1A)
None
 0.13A 6bc9A-3b1bA:
25.0		 6bc9A-3b1bA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		4 HIS A 112
HIS A 182
LEU A 268
VAL A 201
 None
ZN  A 378 (-3.1A)
None
None
 0.95A 6bc9A-3b1bA:
25.0		 6bc9A-3b1bA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cax UNCHARACTERIZED
PROTEIN PF0695

(Pyrococcus
furiosus) 		PF01814
(Hemerythrin)
PF13596
(PAS_10) 		4 GLU A 254
HIS A 179
LEU A 172
VAL A 175
 None
 1.09A 6bc9A-3caxA:
undetectable		 6bc9A-3caxA:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3cny INOSITOL CATABOLISM
PROTEIN IOLE

(Lactobacillus
plantarum) 		PF01261
(AP_endonuc_2) 		4 HIS A 192
GLU A  48
HIS A 213
LEU A 260
 None
 1.06A 6bc9A-3cnyA:
undetectable		 6bc9A-3cnyA:
14.77
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3da2 CARBONIC ANHYDRASE
13

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 HIS A  65
GLU A 107
HIS A 120
LEU A 142
VAL A 144
 None
ZN  A 301 ( 4.9A)
ZN  A 301 ( 3.2A)
None
4MD  A 401 ( 4.4A)
 0.29A 6bc9A-3da2A:
42.4		 6bc9A-3da2A:
30.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3e97 TRANSCRIPTIONAL
REGULATOR, CRP/FNR
FAMILY

(Deinococcus
geothermalis) 		PF00027
(cNMP_binding)
PF13545
(HTH_Crp_2) 		4 GLU A  23
HIS A 118
LEU A  12
VAL A 121
 None
 1.20A 6bc9A-3e97A:
undetectable		 6bc9A-3e97A:
14.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe4 CARBONIC ANHYDRASE 6

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 HIS A  85
GLU A 125
HIS A 138
LEU A 159
VAL A 161
 None
MG  A 901 ( 4.4A)
MG  A 901 (-3.2A)
None
None
 0.61A 6bc9A-3fe4A:
31.6		 6bc9A-3fe4A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3h4r EXODEOXYRIBONUCLEASE
8

(Escherichia
coli) 		PF12684
(DUF3799) 		4 GLU A 729
HIS A 652
LEU A 802
VAL A 760
 None
 1.20A 6bc9A-3h4rA:
undetectable		 6bc9A-3h4rA:
13.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3hrw HEMOGLOBIN SUBUNIT
BETA-1

(Mus musculus) 		PF00042
(Globin) 		4 GLU B  26
HIS B 117
LEU B  14
VAL B  18
 None
 0.97A 6bc9A-3hrwB:
undetectable		 6bc9A-3hrwB:
21.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3l44 GLUTAMATE-1-SEMIALDE
HYDE 2,1-AMINOMUTASE
1

(Bacillus
anthracis) 		PF00202
(Aminotran_3) 		4 GLU A 209
HIS A 148
LEU A 155
VAL A 154
 LLP  A 270 ( 3.9A)
None
None
None
 0.99A 6bc9A-3l44A:
undetectable		 6bc9A-3l44A:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3m3p GLUTAMINE AMIDO
TRANSFERASE

(Methylobacillus
flagellatus) 		PF00117
(GATase) 		4 HIS A 140
GLU A 178
LEU A 128
VAL A 232
 None
 1.13A 6bc9A-3m3pA:
undetectable		 6bc9A-3m3pA:
16.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 HIS A  64
GLU A 106
HIS A 119
LEU A 141
VAL A 143
 None
ZN  A 263 ( 4.6A)
ZN  A 263 ( 3.1A)
None
AZM  A 264 ( 4.9A)
 0.33A 6bc9A-3ml5A:
43.0		 6bc9A-3ml5A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3r3s OXIDOREDUCTASE

(Salmonella
enterica) 		PF13561
(adh_short_C2) 		4 HIS A 292
HIS A 285
LEU A 265
VAL A 268
 None
 1.18A 6bc9A-3r3sA:
undetectable		 6bc9A-3r3sA:
15.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3um6 BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE

(Plasmodium
falciparum) 		PF00186
(DHFR_1)
PF00303
(Thymidylat_synt) 		4 HIS A 598
GLU A 325
HIS A 323
VAL A 210
 None
 1.15A 6bc9A-3um6A:
undetectable		 6bc9A-3um6A:
9.41
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uyq CARBONIC ANHYDRASE 3

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 HIS A  64
GLU A 106
HIS A 119
VAL A 142
 None
ZN  A 261 ( 4.9A)
ZN  A 261 (-3.2A)
None
 0.44A 6bc9A-3uyqA:
41.3		 6bc9A-3uyqA:
32.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3w53 BETA-GLUCOSIDASE

(Micrococcus
antarcticus) 		PF00232
(Glyco_hydro_1) 		4 HIS A 125
HIS A 205
LEU A 255
VAL A 258
 None
 1.02A 6bc9A-3w53A:
undetectable		 6bc9A-3w53A:
9.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zgx CHROMOSOME PARTITION
PROTEIN SMC
SEGREGATION AND
CONDENSATION PROTEIN
A

(Bacillus
subtilis) 		PF02463
(SMC_N)
PF02616
(SMC_ScpA) 		4 GLU C  39
HIS A1043
LEU A1051
VAL A1047
 None
 1.21A 6bc9A-3zgxC:
undetectable		 6bc9A-3zgxC:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3zi1 GLYOXALASE
DOMAIN-CONTAINING
PROTEIN 4

(Homo sapiens) 		no annotation 4 HIS A  34
GLU A  63
LEU A 232
VAL A 240
 None
None
EDO  A1281 ( 3.9A)
None
 1.21A 6bc9A-3zi1A:
undetectable		 6bc9A-3zi1A:
14.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c3o HYDROGENASE-1 LARGE
SUBUNIT

(Salmonella
enterica) 		PF00374
(NiFeSe_Hases) 		4 HIS A 122
GLU A 461
HIS A 115
LEU A 515
 None
None
None
NFU  A1004 (-3.7A)
 1.09A 6bc9A-4c3oA:
undetectable		 6bc9A-4c3oA:
8.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4c7g BETA-N-ACETYLHEXOSAM
INIDASE

(Streptomyces
coelicolor) 		PF00728
(Glyco_hydro_20)
PF02838
(Glyco_hydro_20b) 		4 HIS A 333
GLU A 232
HIS A 174
LEU A 382
 EDO  A1502 ( 4.2A)
None
None
None
 1.17A 6bc9A-4c7gA:
undetectable		 6bc9A-4c7gA:
10.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4cn8 PROXIMAL THREAD
MATRIX PROTEIN 1

(Mytilus
galloprovincialis) 		PF00092
(VWA) 		4 HIS A 184
GLU A 192
LEU A  58
VAL A 168
 None
 1.19A 6bc9A-4cn8A:
undetectable		 6bc9A-4cn8A:
10.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4d7e L-LYS MONOOXYGENASE

(Nocardia
farcinica) 		PF13434
(K_oxygenase) 		4 HIS A  71
GLU A  84
LEU A  23
VAL A  22
 None
 1.11A 6bc9A-4d7eA:
undetectable		 6bc9A-4d7eA:
13.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4eel BETA-PHOSPHOGLUCOMUT
ASE-RELATED PROTEIN

(Deinococcus
radiodurans) 		PF13419
(HAD_2) 		4 HIS A  38
GLU A  43
LEU A  57
VAL A  56
 None
 1.07A 6bc9A-4eelA:
undetectable		 6bc9A-4eelA:
14.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		4 HIS A  64
GLU A  95
HIS A 108
VAL A 120
 None
AZM  A 302 ( 4.6A)
ZN  A 301 ( 3.1A)
AZM  A 302 ( 4.8A)
 0.15A 6bc9A-4g7aA:
30.1		 6bc9A-4g7aA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ka8 OLIGOPEPTIDASE A

(Arabidopsis
thaliana) 		PF01432
(Peptidase_M3) 		4 HIS A 545
GLU A 572
HIS A 575
VAL A 600
 None
ZN  A 801 ( 4.6A)
ZN  A 801 (-3.3A)
None
 1.14A 6bc9A-4ka8A:
undetectable		 6bc9A-4ka8A:
7.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4lr2 BIS(5'-ADENOSYL)-TRI
PHOSPHATASE ENPP4

(Homo sapiens) 		PF01663
(Phosphodiest) 		4 HIS A  48
GLU A  55
HIS A 352
LEU A 226
 None
 1.13A 6bc9A-4lr2A:
undetectable		 6bc9A-4lr2A:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4n5c CARGO-TRANSPORT
PROTEIN YPP1

(Saccharomyces
cerevisiae) 		no annotation 4 HIS A 128
GLU A 149
LEU A  41
VAL A  44
 None
 1.14A 6bc9A-4n5cA:
undetectable		 6bc9A-4n5cA:
8.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4nh0 CELL
DIVISIONFTSK/SPOIIIE

(Thermomonospora
curvata) 		PF01580
(FtsK_SpoIIIE) 		4 HIS A1161
GLU A1207
HIS A1241
LEU A1104
 None
 1.09A 6bc9A-4nh0A:
undetectable		 6bc9A-4nh0A:
6.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4pka PATATIN-17

(Solanum
cardiophyllum) 		PF01734
(Patatin) 		4 GLU X 108
HIS X 109
LEU X 134
VAL X 133
 None
 1.17A 6bc9A-4pkaX:
undetectable		 6bc9A-4pkaX:
14.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ptx GLYCOSIDE HYDROLASE
FAMILY 1

(Halothermothrix
orenii) 		PF00232
(Glyco_hydro_1) 		4 HIS A 121
HIS A 201
LEU A 251
VAL A 254
 BGC  A 501 (-4.2A)
None
None
None
 1.04A 6bc9A-4ptxA:
undetectable		 6bc9A-4ptxA:
10.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4q2e PHOSPHATIDATE
CYTIDYLYLTRANSFERASE

(Thermotoga
maritima) 		PF01148
(CTP_transf_1) 		4 HIS A 248
GLU A 242
LEU A  81
VAL A 134
 None
K  A 305 (-4.4A)
None
None
 1.18A 6bc9A-4q2eA:
undetectable		 6bc9A-4q2eA:
13.78
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		4 GLU A 106
HIS A 119
LEU A 141
VAL A 143
 ZN  A 301 ( 4.5A)
ZN  A 301 (-3.1A)
None
None
 0.10A 6bc9A-4qk3A:
43.8		 6bc9A-4qk3A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rd8 UNCHARACTERIZED
PROTEIN

(Legionella
pneumophila) 		no annotation 4 HIS A 124
HIS A 199
LEU A  36
VAL A  42
 None
 1.16A 6bc9A-4rd8A:
undetectable		 6bc9A-4rd8A:
17.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rfq HISTIDINE PROTEIN
METHYLTRANSFERASE 1
HOMOLOG

(Homo sapiens) 		PF13489
(Methyltransf_23) 		4 GLU A 212
HIS A 214
LEU A 278
VAL A 277
 None
 0.90A 6bc9A-4rfqA:
undetectable		 6bc9A-4rfqA:
15.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4rlq BENZOATE-COENZYME A
LIGASE

(Rhodopseudomonas
palustris) 		PF00501
(AMP-binding)
PF13193
(AMP-binding_C) 		4 GLU A 148
HIS A 121
LEU A  69
VAL A 116
 None
 1.09A 6bc9A-4rlqA:
undetectable		 6bc9A-4rlqA:
10.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)

(Sulfurihydrogenibium
azorense) 		PF00194
(Carb_anhydrase) 		4 HIS A  64
GLU A  95
HIS A 108
VAL A 120
 None
AZM  A 302 ( 4.5A)
ZN  A 301 ( 3.2A)
AZM  A 302 ( 4.8A)
 0.25A 6bc9A-4x5sA:
30.0		 6bc9A-4x5sA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfw ALPHA-CARBONIC
ANHYDRASE

(Helicobacter
pylori) 		PF00194
(Carb_anhydrase) 		4 GLU A 116
HIS A 129
LEU A 139
VAL A 141
 ZN  A 301 (-4.9A)
ZN  A 301 ( 3.1A)
None
None
 0.32A 6bc9A-4xfwA:
26.5		 6bc9A-4xfwA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfw ALPHA-CARBONIC
ANHYDRASE

(Helicobacter
pylori) 		PF00194
(Carb_anhydrase) 		4 HIS A  84
GLU A 116
HIS A 129
VAL A 141
 None
ZN  A 301 (-4.9A)
ZN  A 301 ( 3.1A)
None
 1.05A 6bc9A-4xfwA:
26.5		 6bc9A-4xfwA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfw ALPHA-CARBONIC
ANHYDRASE

(Helicobacter
pylori) 		PF00194
(Carb_anhydrase) 		4 HIS A  85
GLU A 116
HIS A 129
VAL A 141
 None
ZN  A 301 (-4.9A)
ZN  A 301 ( 3.1A)
None
 0.79A 6bc9A-4xfwA:
26.5		 6bc9A-4xfwA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		5 HIS A 134
GLU A 166
HIS A 179
LEU A 190
VAL A 192
 None
2HP  A 402 ( 4.7A)
ZN  A 401 ( 3.1A)
None
None
 0.48A 6bc9A-4xixA:
25.8		 6bc9A-4xixA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		5 HIS A 140
GLU A 171
HIS A 184
LEU A 194
VAL A 196
 None
ZN  A 401 ( 4.5A)
ZN  A 401 ( 3.1A)
None
None
 0.29A 6bc9A-4xz5A:
29.8		 6bc9A-4xz5A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4y7i MYOTUBULARIN-RELATED
PROTEIN 8

(Homo sapiens) 		PF06602
(Myotub-related) 		4 HIS A 379
GLU A 371
LEU A 450
VAL A 452
 None
 1.19A 6bc9A-4y7iA:
undetectable		 6bc9A-4y7iA:
12.76
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4yaq PG9_N100FY FAB HEAVY
CHAIN

(Homo sapiens) 		no annotation 4 GLU H  95
HIS H  35
LEU H  45
VAL H  37
 None
 1.19A 6bc9A-4yaqH:
undetectable		 6bc9A-4yaqH:
13.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5a0k LABDANE-RELATED
DITERPENE SYNTHASE

(Streptomyces
sp.) 		no annotation 4 GLU A 198
HIS A 297
LEU A 212
VAL A 215
 None
 0.77A 6bc9A-5a0kA:
undetectable		 6bc9A-5a0kA:
9.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ams RIBOSOME ASSEMBLY
PROTEIN SQT1

(Saccharomyces
cerevisiae) 		no annotation 4 HIS A 163
GLU A 120
LEU A 191
VAL A 135
 None
 1.13A 6bc9A-5amsA:
undetectable		 6bc9A-5amsA:
11.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 HIS A  64
GLU A 106
HIS A 119
LEU A 141
VAL A 143
 None
ZN  A 301 ( 4.6A)
ZN  A 301 ( 3.1A)
None
520  A 302 ( 4.9A)
 0.18A 6bc9A-5cjfA:
36.8		 6bc9A-5cjfA:
24.52
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		5 HIS X  63
GLU X 105
HIS X 118
LEU X 139
VAL X 141
 None
ZN  X 301 ( 4.6A)
ZN  X 301 (-3.1A)
None
None
 0.29A 6bc9A-5eztX:
44.2		 6bc9A-5eztX:
77.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5f0o COHESIN SUBUNIT
PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P,KLTH0D07062P,C
OHESIN SUBUNIT PDS5,
KLTH0D07062P,KLTH0D0
7062P

(Lachancea
thermotolerans) 		no annotation 4 GLU A 979
HIS A1058
LEU A1076
VAL A1061
 None
 1.01A 6bc9A-5f0oA:
undetectable		 6bc9A-5f0oA:
6.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		5 HIS A  71
GLU A 102
HIS A 115
LEU A 125
VAL A 127
 None
ZN  A 301 ( 4.6A)
ZN  A 301 (-3.1A)
None
None
 0.39A 6bc9A-5hpjA:
29.4		 6bc9A-5hpjA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5i2c GATS-LIKE PROTEIN 3

(Homo sapiens) 		PF13840
(ACT_7) 		4 GLU A 234
HIS A   8
LEU A  79
VAL A  78
 None
 1.12A 6bc9A-5i2cA:
undetectable		 6bc9A-5i2cA:
13.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ig0 CAMK/CAMK2 PROTEIN
KINASE

(Salpingoeca
rosetta) 		PF08332
(CaMKII_AD) 		4 HIS A 470
GLU A 385
LEU A 360
VAL A 363
 None
GOL  A 502 (-2.5A)
None
SO4  A 501 (-4.4A)
 1.21A 6bc9A-5ig0A:
undetectable		 6bc9A-5ig0A:
18.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ktk POLYKETIDE SYNTHASE
PKSJ

(Bacillus
subtilis) 		PF08659
(KR) 		4 HIS A 400
HIS A 357
LEU A 295
VAL A 301
 None
None
NDP  A 601 ( 4.8A)
None
 1.13A 6bc9A-5ktkA:
undetectable		 6bc9A-5ktkA:
7.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5mzy GLUTACONATE
COA-TRANSFERASE
FAMILY, SUBUNIT A

(Myxococcus
xanthus) 		PF01144
(CoA_trans) 		4 GLU A 137
HIS A 104
LEU A 113
VAL A 109
 None
 1.16A 6bc9A-5mzyA:
undetectable		 6bc9A-5mzyA:
14.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5n2k BRIAKINUMAB FAB
HEAVY CHAIN

(Homo sapiens) 		no annotation 4 HIS B 102
HIS B  35
LEU B  45
VAL B  37
 None
 1.06A 6bc9A-5n2kB:
undetectable		 6bc9A-5n2kB:
15.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ogz -

(-) 		no annotation 4 HIS A 121
HIS A 201
LEU A 251
VAL A 254
 None
 1.00A 6bc9A-5ogzA:
undetectable		 6bc9A-5ogzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ons DENSITY-REGULATED
PROTEIN
MALIGNANT
T-CELL-AMPLIFIED
SEQUENCE 1

(Homo sapiens) 		no annotation 4 HIS A 176
HIS A  86
LEU B  32
VAL B  31
 None
 1.05A 6bc9A-5onsA:
undetectable		 6bc9A-5onsA:
15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5t2k PUTATIVE
HEME-DEPENDENT
PEROXIDASE
GT50_08830

(Geobacillus
stearothermophilus) 		PF06778
(Chlor_dismutase) 		4 GLU A  51
HIS A  58
LEU A  41
VAL A  44
 None
 1.10A 6bc9A-5t2kA:
undetectable		 6bc9A-5t2kA:
15.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5yo8 TETRAPRENYL-BETA-CUR
CUMENE SYNTHASE

(Bacillus
alcalophilus) 		no annotation 4 HIS A 301
GLU A 287
LEU A 248
VAL A 244
 None
 1.10A 6bc9A-5yo8A:
undetectable		 6bc9A-5yo8A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c7v -

(-) 		no annotation 4 HIS A  84
GLU A  91
LEU A  65
VAL A  66
 None
 1.19A 6bc9A-6c7vA:
undetectable		 6bc9A-6c7vA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6c9e CYSTEINE DESULFURASE

(Legionella
pneumophila) 		no annotation 4 HIS A 370
HIS A 128
LEU A 149
VAL A 151
 ZN  A 501 ( 4.9A)
None
None
None
 0.66A 6bc9A-6c9eA:
undetectable		 6bc9A-6c9eA:
26.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6czm -

(-) 		no annotation 4 HIS A 126
GLU A 360
HIS A 258
LEU A 371
 None
 1.21A 6bc9A-6czmA:
undetectable		 6bc9A-6czmA:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6eki CARBONIC ANHYDRASE

(Persephonella
marina) 		no annotation 5 HIS A  92
GLU A 123
HIS A 136
LEU A 146
VAL A 148
 None
ZN  A 301 ( 4.7A)
ZN  A 301 (-3.2A)
None
None
 0.28A 6bc9A-6ekiA:
undetectable		 6bc9A-6ekiA:
32.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6fe1 CARBONIC ANHYDRASE 9

(Homo sapiens) 		no annotation 5 HIS A  64
GLU A 106
HIS A 119
LEU A 141
VAL A 143
 None
V14  A 302 (-4.2A)
ZN  A 301 ( 3.1A)
None
None
 0.36A 6bc9A-6fe1A:
undetectable		 6bc9A-6fe1A:
33.33