SIMILAR PATTERNS OF AMINO ACIDS FOR 6BBS_A_BZ1A302_1

List of similar pattern of amino acids derived from ASSAM search

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click link on the last column to view superposed patterns of amino acids in NGL viewer)
(Note that only 3-12 residue patterns can be used for ASSAM searches)
Filter list by:
Hit Macromolecule/
Organism		 Pfam Res. Interface HETATM RMSD Dali Z-score Seq. Identity (%) View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1bc5 CHEMOTAXIS RECEPTOR
METHYLTRANSFERASE

(Salmonella
enterica) 		PF01739
(CheR)
PF03705
(CheR_N) 		5 ASN A 231
HIS A 262
ILE A 227
HIS A 102
HIS A 101
 SAH  A 287 (-4.1A)
None
None
None
None
 1.03A 6bbsA-1bc5A:
undetectable		 6bbsA-1bc5A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1iwp GLYCEROL DEHYDRATASE
ALPHA SUBUNIT

(Klebsiella
pneumoniae) 		PF02286
(Dehydratase_LU) 		5 ASN A 141
ILE A 542
GLN A 392
THR A 347
THR A 350
 None
 1.24A 6bbsA-1iwpA:
undetectable		 6bbsA-1iwpA:
9.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jd0 CARBONIC ANHYDRASE
XII

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		9 ASN A  62
HIS A  64
GLN A  92
HIS A  94
HIS A  96
LEU A 198
THR A 199
THR A 200
TRP A 209
 None
None
AZM  A1400 (-3.2A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.2A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
AZM  A1400 (-3.3A)
None
 0.58A 6bbsA-1jd0A:
29.9		 6bbsA-1jd0A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jd0 CARBONIC ANHYDRASE
XII

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		9 TRP A   5
ASN A  62
HIS A  64
HIS A  94
HIS A  96
LEU A 198
THR A 199
THR A 200
TRP A 209
 None
None
None
ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.2A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.6A)
AZM  A1400 (-3.3A)
None
 0.55A 6bbsA-1jd0A:
29.9		 6bbsA-1jd0A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jd0 CARBONIC ANHYDRASE
XII

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 TRP A   5
HIS A  64
HIS A  94
THR A 199
THR A 200
TRP A 209
 None
None
ZN  A 901 ( 3.2A)
AZM  A1400 (-3.6A)
AZM  A1400 (-3.3A)
None
 1.33A 6bbsA-1jd0A:
29.9		 6bbsA-1jd0A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1jd0 CARBONIC ANHYDRASE
XII

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 TRP A  16
GLN A  92
HIS A  94
HIS A  96
LEU A 198
THR A 200
 None
AZM  A1400 (-3.2A)
ZN  A 901 ( 3.2A)
ZN  A 901 ( 3.2A)
AZM  A1400 (-3.9A)
AZM  A1400 (-3.3A)
 1.45A 6bbsA-1jd0A:
29.9		 6bbsA-1jd0A:
15.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae) 		PF00194
(Carb_anhydrase) 		6 GLN A  69
HIS A  92
HIS A  94
LEU A 176
THR A 177
THR A 178
 None
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.3A)
AZI  A 305 (-4.2A)
AZI  A 305 (-3.4A)
AZI  A 305 ( 4.2A)
 1.16A 6bbsA-1kopA:
24.4		 6bbsA-1kopA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae) 		PF00194
(Carb_anhydrase) 		10 TRP A   7
ASN A  64
HIS A  66
GLN A  90
HIS A  92
HIS A  94
LEU A 176
THR A 177
THR A 178
TRP A 187
 None
BME  A 303 (-4.7A)
BME  A 303 (-3.6A)
None
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.3A)
AZI  A 305 (-4.2A)
AZI  A 305 (-3.4A)
AZI  A 305 ( 4.2A)
None
 0.52A 6bbsA-1kopA:
24.4		 6bbsA-1kopA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1kop CARBONIC ANHYDRASE

(Neisseria
gonorrhoeae) 		PF00194
(Carb_anhydrase) 		6 TRP A   7
HIS A  66
HIS A  92
THR A 177
THR A 178
TRP A 187
 None
BME  A 303 (-3.6A)
ZN  A 301 ( 3.2A)
AZI  A 305 (-3.4A)
AZI  A 305 ( 4.2A)
None
 1.33A 6bbsA-1kopA:
24.4		 6bbsA-1kopA:
21.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		6 GLN A  67
HIS A  94
LEU A 198
THR A 199
THR A 200
TRP A 209
 None
ZN  A 601 ( 3.3A)
AZM  A 400 (-3.7A)
AZM  A 400 (-3.6A)
AZM  A 400 (-3.6A)
None
 1.22A 6bbsA-1rj6A:
30.4		 6bbsA-1rj6A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		9 TRP A   5
ASN A  62
HIS A  64
GLN A  92
HIS A  94
LEU A 198
THR A 199
THR A 200
TRP A 209
 None
None
None
AZM  A 400 (-4.3A)
ZN  A 601 ( 3.3A)
AZM  A 400 (-3.7A)
AZM  A 400 (-3.6A)
AZM  A 400 (-3.6A)
None
 0.78A 6bbsA-1rj6A:
30.4		 6bbsA-1rj6A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1rj6 CARBONIC ANHYDRASE
XIV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		9 TRP A   5
HIS A  64
GLN A  92
HIS A  94
HIS A  96
LEU A 198
THR A 199
THR A 200
TRP A 209
 None
None
AZM  A 400 (-4.3A)
ZN  A 601 ( 3.3A)
ZN  A 601 (-3.3A)
AZM  A 400 (-3.7A)
AZM  A 400 (-3.6A)
AZM  A 400 (-3.6A)
None
 0.56A 6bbsA-1rj6A:
30.4		 6bbsA-1rj6A:
15.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urt CARBONIC ANHYDRASE V

(Mus musculus) 		PF00194
(Carb_anhydrase) 		5 GLN A  67
LEU A 198
THR A 199
THR A 200
TRP A 209
 None
None
ZN  A 280 ( 4.9A)
None
None
 1.24A 6bbsA-1urtA:
30.7		 6bbsA-1urtA:
26.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1urt CARBONIC ANHYDRASE V

(Mus musculus) 		PF00194
(Carb_anhydrase) 		7 GLN A  92
HIS A  94
HIS A  96
LEU A 198
THR A 199
THR A 200
TRP A 209
 None
ZN  A 280 (-3.2A)
ZN  A 280 (-3.2A)
None
ZN  A 280 ( 4.9A)
None
None
 0.41A 6bbsA-1urtA:
30.7		 6bbsA-1urtA:
26.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1y7w HALOTOLERANT
ALPHA-TYPE CARBONIC
ANHYDRASE (DCA II)

(Dunaliella
salina) 		PF00194
(Carb_anhydrase) 		8 ILE A 112
GLN A 113
HIS A 115
HIS A 117
LEU A 216
THR A 217
THR A 218
TRP A 227
 None
None
ZN  A 283 ( 3.2A)
ZN  A 283 (-3.2A)
ACY  A 279 (-4.3A)
ACY  A 279 (-3.4A)
ACY  A 279 ( 4.9A)
None
 0.52A 6bbsA-1y7wA:
21.9		 6bbsA-1y7wA:
15.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2it4 CARBONIC ANHYDRASE 1

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 TRP A   5
GLN A  92
HIS A  94
HIS A  96
LEU A 198
THR A 199
TRP A 209
 None
None
ZN  A 561 ( 3.2A)
ZN  A 561 ( 3.2A)
PPF  A 500 (-3.9A)
PPF  A 500 (-3.6A)
None
 0.72A 6bbsA-2it4A:
32.6		 6bbsA-2it4A:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2j CARBONIC
ANHYDRASE-RELATED
PROTEIN

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 HIS A  87
ILE A 153
HIS A 118
THR A 223
TRP A 233
 None
UNX  A 603 ( 4.9A)
CL  A 401 (-4.2A)
CL  A 401 ( 4.8A)
None
 0.81A 6bbsA-2w2jA:
30.1		 6bbsA-2w2jA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2w2j CARBONIC
ANHYDRASE-RELATED
PROTEIN

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 TRP A  29
HIS A  87
HIS A 118
LEU A 222
THR A 223
TRP A 233
 None
None
CL  A 401 (-4.2A)
None
CL  A 401 ( 4.8A)
None
 0.57A 6bbsA-2w2jA:
30.1		 6bbsA-2w2jA:
22.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2znc CARBONIC ANHYDRASE
IV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		5 HIS A 107
HIS A  96
THR A 200
THR A 199
TRP A   5
 None
ZN  A   1 ( 3.3A)
None
ZN  A   1 ( 4.7A)
None
 1.24A 6bbsA-2zncA:
27.9		 6bbsA-2zncA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2znc CARBONIC ANHYDRASE
IV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		10 TRP A   5
ASN A  62
HIS A  64
GLN A  92
HIS A  94
HIS A  96
LEU A 198
THR A 199
THR A 200
TRP A 209
 None
None
None
None
ZN  A   1 ( 3.3A)
ZN  A   1 ( 3.3A)
None
ZN  A   1 ( 4.7A)
None
None
 0.58A 6bbsA-2zncA:
27.9		 6bbsA-2zncA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2znc CARBONIC ANHYDRASE
IV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		6 TRP A   5
ASN A  62
HIS A  64
GLN A  92
HIS A  94
PHE A 141
 None
None
None
None
ZN  A   1 ( 3.3A)
None
 1.42A 6bbsA-2zncA:
27.9		 6bbsA-2zncA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2znc CARBONIC ANHYDRASE
IV

(Mus musculus) 		PF00194
(Carb_anhydrase) 		6 TRP A   5
HIS A  64
HIS A  94
THR A 199
THR A 200
TRP A 209
 None
None
ZN  A   1 ( 3.3A)
ZN  A   1 ( 4.7A)
None
None
 1.32A 6bbsA-2zncA:
27.9		 6bbsA-2zncA:
24.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ako VENUS

(Plant
transformation
vector
pSITEII-4C1) 		PF01353
(GFP) 		5 HIS A 148
ILE B 161
PHE A  84
THR A  63
THR A  62
 CR2  A  66 ( 3.8A)
None
None
None
CR2  A  66 ( 4.5A)
 1.22A 6bbsA-3akoA:
undetectable		 6bbsA-3akoA:
21.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		6 GLN A 115
HIS A 163
LEU A 259
THR A 260
THR A 261
TRP A 270
 None
ZN  A 378 (-3.2A)
None
ZN  A 378 ( 4.5A)
None
None
 1.17A 6bbsA-3b1bA:
20.3		 6bbsA-3b1bA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		10 TRP A  40
ASN A 110
HIS A 112
GLN A 161
HIS A 163
HIS A 165
LEU A 259
THR A 260
THR A 261
TRP A 270
 None
None
None
None
ZN  A 378 (-3.2A)
ZN  A 378 (-3.3A)
None
ZN  A 378 ( 4.5A)
None
None
 0.50A 6bbsA-3b1bA:
20.3		 6bbsA-3b1bA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3b1b CARBONIC ANHYDRASE 1

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		6 TRP A  40
HIS A 112
HIS A 163
THR A 260
THR A 261
TRP A 270
 None
None
ZN  A 378 (-3.2A)
ZN  A 378 ( 4.5A)
None
None
 1.28A 6bbsA-3b1bA:
20.3		 6bbsA-3b1bA:
11.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3c4q PREDICTED
GLYCOSYLTRANSFERASES

(Corynebacterium
glutamicum) 		PF00534
(Glycos_transf_1)
PF13439
(Glyco_transf_4) 		5 TRP A 391
ASN A 171
HIS A 109
LEU A  35
THR A  31
 None
 1.22A 6bbsA-3c4qA:
undetectable		 6bbsA-3c4qA:
14.64
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3da2 CARBONIC ANHYDRASE
13

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 HIS A  65
GLN A  93
HIS A  95
HIS A  97
LEU A 199
THR A 200
TRP A 210
 None
4MD  A 401 (-3.1A)
ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.5A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
None
 0.97A 6bbsA-3da2A:
32.9		 6bbsA-3da2A:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3da2 CARBONIC ANHYDRASE
13

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 HIS A  65
GLN A  93
HIS A  97
PHE A 132
LEU A 199
THR A 200
TRP A 210
 None
4MD  A 401 (-3.1A)
ZN  A 301 ( 3.5A)
4MD  A 401 (-4.6A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
None
 1.03A 6bbsA-3da2A:
32.9		 6bbsA-3da2A:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3da2 CARBONIC ANHYDRASE
13

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 TRP A   6
HIS A  65
HIS A  95
HIS A  97
LEU A 199
THR A 200
TRP A 210
 None
None
ZN  A 301 ( 3.6A)
ZN  A 301 ( 3.5A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
None
 0.69A 6bbsA-3da2A:
32.9		 6bbsA-3da2A:
30.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3da2 CARBONIC ANHYDRASE
13

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 TRP A   6
HIS A  65
HIS A  97
PHE A 132
LEU A 199
THR A 200
TRP A 210
 None
None
ZN  A 301 ( 3.5A)
4MD  A 401 (-4.6A)
4MD  A 401 (-4.2A)
4MD  A 401 (-3.2A)
None
 0.72A 6bbsA-3da2A:
32.9		 6bbsA-3da2A:
30.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ed8 YELLOW FLUORESCENCE
PROTEIN

(Aequorea
victoria) 		PF01353
(GFP) 		5 HIS A 148
ILE A 185
PHE A  84
THR A  63
THR A  62
 CRO  A  66 ( 3.9A)
None
None
None
CRO  A  66 ( 4.5A)
 1.16A 6bbsA-3ed8A:
undetectable		 6bbsA-3ed8A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3fe4 CARBONIC ANHYDRASE 6

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		8 ASN A  83
HIS A  85
GLN A 109
HIS A 111
HIS A 113
LEU A 219
THR A 220
TRP A 230
 None
None
None
MG  A 901 (-3.4A)
MG  A 901 (-3.4A)
None
None
None
 0.70A 6bbsA-3fe4A:
27.9		 6bbsA-3fe4A:
16.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jb9 PRE-MRNA-SPLICING
FACTOR CWF15
PRE-MRNA-SPLICING
FACTOR SPP42

(Schizosaccharomyces
pombe) 		PF01423
(LSM)
PF08082
(PRO8NT)
PF08083
(PROCN)
PF10596
(U6-snRNA_bdg)
PF10597
(U5_2-snRNA_bdg)
PF10598
(RRM_4)
PF12134
(PRP8_domainIV) 		5 ILE A1120
HIS h 235
LEU A1004
THR A1192
THR A1191
 None
 1.18A 6bbsA-3jb9A:
undetectable		 6bbsA-3jb9A:
2.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3jxf RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE ZETA

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 TRP A  38
HIS A 129
LEU A 235
THR A 236
TRP A 246
 None
 0.57A 6bbsA-3jxfA:
28.6		 6bbsA-3jxfA:
12.64
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 ASN A  62
HIS A  64
GLN A  92
HIS A  94
HIS A  96
PHE A 131
THR A 200
 None
None
AZM  A 264 (-4.1A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
AZM  A 264 (-4.4A)
AZM  A 264 (-3.5A)
 0.78A 6bbsA-3ml5A:
33.1		 6bbsA-3ml5A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 GLN A  67
HIS A  94
HIS A  96
LEU A 198
THR A 199
THR A 200
 None
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
 1.13A 6bbsA-3ml5A:
33.1		 6bbsA-3ml5A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		10 TRP A   5
ASN A  62
HIS A  64
GLN A  92
HIS A  94
HIS A  96
LEU A 198
THR A 199
THR A 200
TRP A 209
 None
None
None
AZM  A 264 (-4.1A)
ZN  A 263 ( 3.2A)
ZN  A 263 ( 3.2A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
None
 0.59A 6bbsA-3ml5A:
33.1		 6bbsA-3ml5A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ml5 CARBONIC ANHYDRASE 7

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 TRP A   5
HIS A  64
HIS A  94
THR A 199
THR A 200
TRP A 209
 None
None
ZN  A 263 ( 3.2A)
AZM  A 264 (-3.4A)
AZM  A 264 (-3.5A)
None
 1.36A 6bbsA-3ml5A:
33.1		 6bbsA-3ml5A:
18.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q31 CARBONIC ANHYDRASE

(Aspergillus
oryzae) 		PF00194
(Carb_anhydrase) 		7 GLN A 121
HIS A 123
HIS A 125
LEU A 214
THR A 215
THR A 216
TRP A 225
 MLT  A   3 (-3.9A)
ZN  A   1 ( 3.2A)
ZN  A   1 (-3.3A)
MLT  A   3 ( 4.2A)
MLT  A   3 ( 4.3A)
MLT  A   3 (-2.8A)
MLT  A   3 (-4.9A)
 0.48A 6bbsA-3q31A:
20.1		 6bbsA-3q31A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3q31 CARBONIC ANHYDRASE

(Aspergillus
oryzae) 		PF00194
(Carb_anhydrase) 		6 TRP A  48
GLN A 121
HIS A 123
HIS A 125
LEU A 214
THR A 216
 None
MLT  A   3 (-3.9A)
ZN  A   1 ( 3.2A)
ZN  A   1 (-3.3A)
MLT  A   3 ( 4.2A)
MLT  A   3 (-2.8A)
 1.39A 6bbsA-3q31A:
20.1		 6bbsA-3q31A:
15.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3sks PUTATIVE
OLIGOENDOPEPTIDASE F

(Bacillus
anthracis) 		no annotation 5 ASN A 343
ILE A 150
PHE A 184
THR A  66
THR A  65
 None
 0.97A 6bbsA-3sksA:
undetectable		 6bbsA-3sksA:
8.70
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uyq CARBONIC ANHYDRASE 3

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		10 TRP A   5
ASN A  62
HIS A  64
GLN A  92
HIS A  94
HIS A  96
PHE A 130
THR A 198
THR A 199
TRP A 208
 None
None
None
None
ZN  A 261 (-3.3A)
ZN  A 261 (-3.3A)
None
ZN  A 261 ( 4.4A)
None
None
 0.73A 6bbsA-3uyqA:
33.4		 6bbsA-3uyqA:
32.43
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3uyq CARBONIC ANHYDRASE 3

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 TRP A   5
HIS A  64
HIS A  94
THR A 198
THR A 199
TRP A 208
 None
None
ZN  A 261 (-3.3A)
ZN  A 261 ( 4.4A)
None
None
 1.40A 6bbsA-3uyqA:
33.4		 6bbsA-3uyqA:
32.43
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4bdu GREEN FLUORESCENT
PROTEIN, APOPTOSIS
REGULATOR BAX

(Aequorea
victoria;
Homo sapiens) 		PF00452
(Bcl-2)
PF01353
(GFP) 		5 HIS A 148
ILE A 161
PHE A  84
THR A  63
THR A  62
 CR2  A  65 ( 4.3A)
None
None
None
None
 1.20A 6bbsA-4bduA:
undetectable		 6bbsA-4bduA:
13.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		7 GLN A  67
HIS A  89
HIS A  91
LEU A 173
THR A 174
THR A 175
TRP A 184
 None
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
AZM  A 302 (-3.8A)
AZM  A 302 (-3.4A)
AZM  A 302 (-3.4A)
None
 1.19A 6bbsA-4g7aA:
24.4		 6bbsA-4g7aA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		10 TRP A   3
ASN A  62
HIS A  64
GLN A  87
HIS A  89
HIS A  91
LEU A 173
THR A 174
THR A 175
TRP A 184
 None
None
None
AZM  A 302 (-4.4A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
AZM  A 302 (-3.8A)
AZM  A 302 (-3.4A)
AZM  A 302 (-3.4A)
None
 0.55A 6bbsA-4g7aA:
24.4		 6bbsA-4g7aA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4g7a CARBONATE
DEHYDRATASE

(Sulfurihydrogenibium
sp. YO3AOP1) 		PF00194
(Carb_anhydrase) 		6 TRP A   3
HIS A  64
HIS A  89
THR A 174
THR A 175
TRP A 184
 None
None
ZN  A 301 ( 3.2A)
AZM  A 302 (-3.4A)
AZM  A 302 (-3.4A)
None
 1.42A 6bbsA-4g7aA:
24.4		 6bbsA-4g7aA:
17.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4jrb GREEN FLUORESCENT
PROTEIN

(Aequorea
victoria;
Blattella
germanica) 		PF01353
(GFP)
PF06757
(Ins_allergen_rp) 		5 HIS A 148
ILE A 161
PHE A  84
THR A  63
THR A  62
 CR2  A  66 ( 4.0A)
None
None
None
CR2  A  66 ( 4.8A)
 1.24A 6bbsA-4jrbA:
undetectable		 6bbsA-4jrbA:
10.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4kf5 FLUORESCENT PROTEIN
GFP1-9

(synthetic
construct) 		PF01353
(GFP) 		5 HIS A 148
ILE A 161
PHE A  84
THR A  63
THR A  62
 CRO  A  66 ( 4.2A)
None
None
None
CRO  A  66 ( 4.5A)
 1.19A 6bbsA-4kf5A:
undetectable		 6bbsA-4kf5A:
18.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4l0k DRAIII

(Deinococcus
radiophilus) 		no annotation 5 ILE A 116
HIS A 189
HIS A 183
PHE A  35
THR A 181
 None
 1.21A 6bbsA-4l0kA:
undetectable		 6bbsA-4l0kA:
17.62
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 HIS A 107
HIS A  96
LEU A 203
THR A 200
THR A 199
TRP A   5
 None
ZN  A 301 (-3.2A)
None
None
ZN  A 301 ( 4.4A)
None
 1.42A 6bbsA-4qk3A:
32.1		 6bbsA-4qk3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		11 TRP A   5
ASN A  62
ILE A  91
GLN A  92
HIS A  94
HIS A  96
PHE A 131
LEU A 198
THR A 199
THR A 200
TRP A 209
 None
None
None
None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
None
None
ZN  A 301 ( 4.4A)
None
None
 0.70A 6bbsA-4qk3A:
32.1		 6bbsA-4qk3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 TRP A   5
HIS A  94
THR A 199
THR A 200
TRP A 209
 None
ZN  A 301 (-3.2A)
ZN  A 301 ( 4.4A)
None
None
 1.03A 6bbsA-4qk3A:
32.1		 6bbsA-4qk3A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4qk3 CARBONIC ANHYDRASE 2

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		6 TRP A 209
HIS A 107
LEU A 203
THR A 200
THR A 199
TRP A   5
 None
None
None
None
ZN  A 301 ( 4.4A)
None
 1.39A 6bbsA-4qk3A:
32.1		 6bbsA-4qk3A:
100.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4s3j CORTICAL-LYTIC
ENZYME

(Bacillus cereus) 		PF00704
(Glyco_hydro_18)
PF01476
(LysM) 		5 ILE A 188
HIS A 266
PHE A 198
THR A 249
THR A 248
 None
 1.17A 6bbsA-4s3jA:
undetectable		 6bbsA-4s3jA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uov CARBONATE
DEHYDRATASE

(Thermovibrio
ammonificans) 		PF00194
(Carb_anhydrase) 		9 TRP A  26
ASN A  85
GLN A 110
HIS A 112
HIS A 114
LEU A 197
THR A 198
THR A 199
TRP A 208
 None
None
CL  A 304 ( 3.7A)
ZN  A 298 (-3.2A)
ZN  A 298 ( 3.2A)
AZM  A 299 (-3.8A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 0.52A 6bbsA-4uovA:
25.2		 6bbsA-4uovA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4uov CARBONATE
DEHYDRATASE

(Thermovibrio
ammonificans) 		PF00194
(Carb_anhydrase) 		5 TRP A  26
HIS A 112
THR A 198
THR A 199
TRP A 208
 None
ZN  A 298 (-3.2A)
AZM  A 299 (-3.3A)
AZM  A 299 (-3.3A)
None
 1.17A 6bbsA-4uovA:
25.2		 6bbsA-4uovA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4wd9 NISIN BIOSYNTHESIS
PROTEIN NISB

(Lactococcus
lactis) 		PF04738
(Lant_dehydr_N)
PF14028
(Lant_dehydr_C) 		5 ASN A 927
GLN A 761
PHE A 773
LEU A 851
THR A 852
 None
 1.08A 6bbsA-4wd9A:
undetectable		 6bbsA-4wd9A:
5.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)

(Sulfurihydrogenibium
azorense) 		PF00194
(Carb_anhydrase) 		6 GLN A  67
HIS A  89
LEU A 173
THR A 174
THR A 175
TRP A 184
 None
ZN  A 301 ( 3.1A)
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
AZM  A 302 (-3.3A)
None
 1.23A 6bbsA-4x5sA:
23.8		 6bbsA-4x5sA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)

(Sulfurihydrogenibium
azorense) 		PF00194
(Carb_anhydrase) 		10 TRP A   3
ASN A  62
HIS A  64
GLN A  87
HIS A  89
HIS A  91
LEU A 173
THR A 174
THR A 175
TRP A 184
 None
None
None
AZM  A 302 (-4.3A)
ZN  A 301 ( 3.1A)
ZN  A 301 ( 3.2A)
AZM  A 302 (-3.7A)
AZM  A 302 (-3.3A)
AZM  A 302 (-3.3A)
None
 0.56A 6bbsA-4x5sA:
23.8		 6bbsA-4x5sA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4x5s CARBONIC ANHYDRASE
(CARBONATE
DEHYDRATASE)

(Sulfurihydrogenibium
azorense) 		PF00194
(Carb_anhydrase) 		6 TRP A   3
HIS A  64
HIS A  89
THR A 174
THR A 175
TRP A 184
 None
None
ZN  A 301 ( 3.1A)
AZM  A 302 (-3.3A)
AZM  A 302 (-3.3A)
None
 1.45A 6bbsA-4x5sA:
23.8		 6bbsA-4x5sA:
19.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfw ALPHA-CARBONIC
ANHYDRASE

(Helicobacter
pylori) 		PF00194
(Carb_anhydrase) 		6 HIS A  84
HIS A 110
HIS A 112
LEU A 190
THR A 191
TRP A 201
 None
ZN  A 301 (-3.3A)
ZN  A 301 (-3.4A)
None
ZN  A 301 (-4.3A)
None
 1.06A 6bbsA-4xfwA:
22.0		 6bbsA-4xfwA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfw ALPHA-CARBONIC
ANHYDRASE

(Helicobacter
pylori) 		PF00194
(Carb_anhydrase) 		5 HIS A  85
HIS A 110
HIS A 112
THR A 191
TRP A 201
 None
ZN  A 301 (-3.3A)
ZN  A 301 (-3.4A)
ZN  A 301 (-4.3A)
None
 0.74A 6bbsA-4xfwA:
22.0		 6bbsA-4xfwA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xfw ALPHA-CARBONIC
ANHYDRASE

(Helicobacter
pylori) 		PF00194
(Carb_anhydrase) 		6 TRP A  23
HIS A 110
HIS A 112
LEU A 190
THR A 191
TRP A 201
 None
ZN  A 301 (-3.3A)
ZN  A 301 (-3.4A)
None
ZN  A 301 (-4.3A)
None
 0.64A 6bbsA-4xfwA:
22.0		 6bbsA-4xfwA:
19.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		7 GLN A 138
HIS A 160
HIS A 162
LEU A 253
THR A 254
THR A 255
TRP A 264
 None
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.2A)
2HP  A 402 (-3.4A)
2HP  A 402 (-2.9A)
2HP  A 402 (-3.6A)
None
 1.07A 6bbsA-4xixA:
20.6		 6bbsA-4xixA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		8 HIS A 134
GLN A 158
HIS A 160
HIS A 162
LEU A 253
THR A 254
THR A 255
TRP A 264
 None
None
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.2A)
2HP  A 402 (-3.4A)
2HP  A 402 (-2.9A)
2HP  A 402 (-3.6A)
None
 0.59A 6bbsA-4xixA:
20.6		 6bbsA-4xixA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xix CARBONIC ANHYDRASE,
ALPHA TYPE

(Chlamydomonas
reinhardtii) 		PF00194
(Carb_anhydrase) 		5 HIS A 134
HIS A 160
THR A 254
THR A 255
TRP A 264
 None
ZN  A 401 ( 3.2A)
2HP  A 402 (-2.9A)
2HP  A 402 (-3.6A)
None
 1.17A 6bbsA-4xixA:
20.6		 6bbsA-4xixA:
25.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		6 GLN A 143
HIS A 165
HIS A 167
LEU A 251
THR A 252
THR A 253
 None
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.3A)
BCT  A 402 (-3.8A)
BCT  A 402 (-3.7A)
BCT  A 402 ( 4.4A)
 1.18A 6bbsA-4xz5A:
24.9		 6bbsA-4xz5A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		5 HIS A 172
HIS A 167
THR A 253
THR A 252
TRP A  78
 None
ZN  A 401 ( 3.3A)
BCT  A 402 ( 4.4A)
BCT  A 402 (-3.7A)
None
 1.24A 6bbsA-4xz5A:
24.9		 6bbsA-4xz5A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		10 TRP A  78
ASN A 138
HIS A 140
GLN A 163
HIS A 165
HIS A 167
LEU A 251
THR A 252
THR A 253
TRP A 262
 None
None
None
None
ZN  A 401 ( 3.2A)
ZN  A 401 ( 3.3A)
BCT  A 402 (-3.8A)
BCT  A 402 (-3.7A)
BCT  A 402 ( 4.4A)
None
 0.55A 6bbsA-4xz5A:
24.9		 6bbsA-4xz5A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4xz5 CARBONIC ANHYDRASE,
ALPHA FAMILY

(Hydrogenovibrio
crunogenus) 		PF00194
(Carb_anhydrase) 		6 TRP A  78
HIS A 140
HIS A 165
THR A 252
THR A 253
TRP A 262
 None
None
ZN  A 401 ( 3.2A)
BCT  A 402 (-3.7A)
BCT  A 402 ( 4.4A)
None
 1.32A 6bbsA-4xz5A:
24.9		 6bbsA-4xz5A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 GLN A  67
HIS A  94
HIS A  96
LEU A 198
THR A 199
THR A 200
TRP A 209
 GOL  A 303 (-3.4A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
None
 1.13A 6bbsA-5cjfA:
29.6		 6bbsA-5cjfA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		10 TRP A   5
ASN A  62
HIS A  64
GLN A  92
HIS A  94
HIS A  96
LEU A 198
THR A 199
THR A 200
TRP A 209
 None
GOL  A 303 (-3.9A)
None
GOL  A 303 (-3.2A)
ZN  A 301 (-3.2A)
ZN  A 301 ( 3.2A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
None
 0.52A 6bbsA-5cjfA:
29.6		 6bbsA-5cjfA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5cjf CARBONIC ANHYDRASE
14

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		7 TRP A   5
HIS A  64
HIS A  94
LEU A 198
THR A 199
THR A 200
TRP A 209
 None
None
ZN  A 301 (-3.2A)
520  A 302 (-3.6A)
520  A 302 (-3.4A)
GOL  A 303 ( 3.5A)
None
 1.48A 6bbsA-5cjfA:
29.6		 6bbsA-5cjfA:
24.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ck0 SUSD HOMOLOG

(Bacteroides
thetaiotaomicron) 		PF07980
(SusD_RagB)
PF14322
(SusD-like_3) 		5 HIS A 151
PHE A 572
LEU A 105
THR A 108
THR A 109
 None
 1.20A 6bbsA-5ck0A:
undetectable		 6bbsA-5ck0A:
8.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e5u RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE GAMMA

(Mus musculus) 		PF00194
(Carb_anhydrase) 		6 TRP A  60
HIS A 151
LEU A 256
THR A 257
THR A 258
TRP A 267
 None
 0.66A 6bbsA-5e5uA:
29.1		 6bbsA-5e5uA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e5u RECEPTOR-TYPE
TYROSINE-PROTEIN
PHOSPHATASE GAMMA

(Mus musculus) 		PF00194
(Carb_anhydrase) 		6 TRP A  60
HIS A 151
PHE A 187
LEU A 256
THR A 257
THR A 258
 None
 0.96A 6bbsA-5e5uA:
29.1		 6bbsA-5e5uA:
14.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5e78 BIFUNCTIONAL
P-450/NADPH-P450
REDUCTASE

(Bacillus
megaterium) 		PF00067
(p450) 		5 HIS A 266
PHE A  81
LEU A 437
THR A 438
THR A 436
 None
 1.07A 6bbsA-5e78A:
undetectable		 6bbsA-5e78A:
10.71
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		6 HIS X 106
HIS X  95
LEU X 201
THR X 198
THR X 197
TRP X   4
 None
ZN  X 301 (-3.2A)
None
None
ZN  X 301 ( 4.4A)
None
 1.40A 6bbsA-5eztX:
33.8		 6bbsA-5eztX:
77.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		11 TRP X   4
ASN X  61
HIS X  63
GLN X  91
HIS X  93
HIS X  95
PHE X 129
LEU X 196
THR X 197
THR X 198
TRP X 207
 None
None
None
None
ZN  X 301 (-3.2A)
ZN  X 301 (-3.2A)
None
None
ZN  X 301 ( 4.4A)
None
None
 0.69A 6bbsA-5eztX:
33.8		 6bbsA-5eztX:
77.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		6 TRP X   4
HIS X  63
HIS X  93
THR X 197
THR X 198
TRP X 207
 None
None
ZN  X 301 (-3.2A)
ZN  X 301 ( 4.4A)
None
None
 1.16A 6bbsA-5eztX:
33.8		 6bbsA-5eztX:
77.92
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
5ezt CARBONIC ANHYDRASE 2

(Bos taurus) 		PF00194
(Carb_anhydrase) 		6 TRP X 207
HIS X 106
LEU X 201
THR X 198
THR X 197
TRP X   4
 None
None
None
None
ZN  X 301 ( 4.4A)
None
 1.41A 6bbsA-5eztX:
33.8		 6bbsA-5eztX:
77.92
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		9 ASN A  69
HIS A  71
GLN A  94
HIS A  96
HIS A  98
LEU A 181
THR A 182
THR A 183
TRP A 192
 None
None
None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
None
ZN  A 301 ( 4.4A)
None
None
 0.57A 6bbsA-5hpjA:
23.4		 6bbsA-5hpjA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		5 GLN A  74
HIS A  98
LEU A 181
THR A 182
THR A 183
 None
ZN  A 301 (-3.2A)
None
ZN  A 301 ( 4.4A)
None
 1.11A 6bbsA-5hpjA:
23.4		 6bbsA-5hpjA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		8 TRP A  15
HIS A  71
HIS A  96
HIS A  98
LEU A 181
THR A 182
THR A 183
TRP A 192
 None
None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
None
ZN  A 301 ( 4.4A)
None
None
 0.63A 6bbsA-5hpjA:
23.4		 6bbsA-5hpjA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		6 TRP A  15
HIS A  71
HIS A  96
THR A 182
THR A 183
TRP A 192
 None
None
ZN  A 301 (-3.2A)
ZN  A 301 ( 4.4A)
None
None
 1.35A 6bbsA-5hpjA:
23.4		 6bbsA-5hpjA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5hpj CARBONIC ANHYDRASE

(Photobacterium
profundum) 		PF00194
(Carb_anhydrase) 		6 TRP A  26
GLN A  94
HIS A  96
HIS A  98
LEU A 181
THR A 183
 None
None
ZN  A 301 (-3.2A)
ZN  A 301 (-3.2A)
None
None
 1.46A 6bbsA-5hpjA:
23.4		 6bbsA-5hpjA:
20.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jn9 CARBONIC ANHYDRASE 4

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 HIS A 107
HIS A  96
THR A 200
THR A 199
TRP A   5
 None
ZN  A 301 ( 3.3A)
EZL  A 302 (-3.9A)
EZL  A 302 (-3.4A)
None
 1.18A 6bbsA-5jn9A:
27.4		 6bbsA-5jn9A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jn9 CARBONIC ANHYDRASE 4

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		9 TRP A   5
ASN A  62
GLN A  92
HIS A  94
HIS A  96
LEU A 198
THR A 199
THR A 200
TRP A 209
 None
None
EZL  A 302 (-4.3A)
ZN  A 301 ( 3.3A)
ZN  A 301 ( 3.3A)
EZL  A 302 (-3.5A)
EZL  A 302 (-3.4A)
EZL  A 302 (-3.9A)
None
 0.61A 6bbsA-5jn9A:
27.4		 6bbsA-5jn9A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5jn9 CARBONIC ANHYDRASE 4

(Homo sapiens) 		PF00194
(Carb_anhydrase) 		5 TRP A   5
HIS A  94
THR A 199
THR A 200
TRP A 209
 None
ZN  A 301 ( 3.3A)
EZL  A 302 (-3.4A)
EZL  A 302 (-3.9A)
None
 1.19A 6bbsA-5jn9A:
27.4		 6bbsA-5jn9A:
13.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ktg GREEN FLUORESCENT
PROTEIN, BCL-2
HOMOLOGOUS
ANTAGONIST/KILLER

(Aequorea
victoria;
Mus musculus) 		PF00452
(Bcl-2)
PF01353
(GFP) 		5 HIS A 148
ILE A 161
PHE A  84
THR A  63
THR A  62
 CR2  A  66 ( 3.9A)
None
None
None
None
 1.21A 6bbsA-5ktgA:
undetectable		 6bbsA-5ktgA:
13.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6aph ADENOSYLHOMOCYSTEINA
SE

(Elizabethkingia
anophelis) 		PF00670
(AdoHcyase_NAD)
PF05221
(AdoHcyase) 		5 ASN A 309
ILE A  84
PHE A 113
THR A 162
THR A 164
 None
None
None
NAD  A 500 ( 2.9A)
NAD  A 500 (-3.7A)
 1.04A 6bbsA-6aphA:
undetectable		 6bbsA-6aphA:
10.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6byo VOLTAGE-DEPENDENT
L-TYPE CALCIUM
CHANNEL SUBUNIT
ALPHA-1S

(Oryctolagus
cuniculus) 		no annotation 5 ASN A 797
HIS A 793
PHE A 863
THR A 852
THR A 853
 None
 1.15A 6bbsA-6byoA:
undetectable		 6bbsA-6byoA:
20.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6eki CARBONIC ANHYDRASE

(Persephonella
marina) 		no annotation 10 TRP A  33
ASN A  90
HIS A  92
GLN A 115
HIS A 117
HIS A 119
LEU A 201
THR A 202
THR A 203
TRP A 212
 None
None
None
None
ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
None
ZN  A 301 (-4.4A)
None
None
 0.65A 6bbsA-6ekiA:
23.8		 6bbsA-6ekiA:
32.14
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6fe1 CARBONIC ANHYDRASE 9

(Homo sapiens) 		no annotation 10 TRP A   5
ASN A  62
HIS A  64
GLN A  92
HIS A  94
HIS A  96
LEU A 198
THR A 199
THR A 200
TRP A 209
 None
V14  A 302 (-3.4A)
None
V14  A 302 (-3.8A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
V14  A 302 (-3.6A)
V14  A 302 (-3.2A)
V14  A 302 (-3.5A)
None
 0.63A 6bbsA-6fe1A:
27.8		 6bbsA-6fe1A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6fe1 CARBONIC ANHYDRASE 9

(Homo sapiens) 		no annotation 6 TRP A   5
HIS A  64
HIS A  94
THR A 199
THR A 200
TRP A 209
 None
None
ZN  A 301 ( 3.2A)
V14  A 302 (-3.2A)
V14  A 302 (-3.5A)
None
 1.46A 6bbsA-6fe1A:
27.8		 6bbsA-6fe1A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6fe1 CARBONIC ANHYDRASE 9

(Homo sapiens) 		no annotation 6 TRP A   5
HIS A  64
HIS A  96
LEU A 198
THR A 200
TRP A 209
 None
None
ZN  A 301 ( 3.2A)
V14  A 302 (-3.6A)
V14  A 302 (-3.5A)
None
 1.32A 6bbsA-6fe1A:
27.8		 6bbsA-6fe1A:
33.33
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6fe1 CARBONIC ANHYDRASE 9

(Homo sapiens) 		no annotation 6 TRP A  16
GLN A  92
HIS A  94
HIS A  96
LEU A 198
THR A 200
 None
V14  A 302 (-3.8A)
ZN  A 301 ( 3.2A)
ZN  A 301 ( 3.2A)
V14  A 302 (-3.6A)
V14  A 302 (-3.5A)
 1.47A 6bbsA-6fe1A:
27.8		 6bbsA-6fe1A:
33.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6gbn -

(-) 		no annotation 5 ASN A 307
ILE A  82
PHE A 111
THR A 160
THR A 162
 None
None
None
NAD  A 502 ( 2.8A)
NAD  A 502 (-3.7A)
 1.01A 6bbsA-6gbnA:
undetectable		 6bbsA-6gbnA:
undetectable